Prof. Carmit Levy

Prof. Levy is in the Department of Human Molecular Genetics and Biochemistry. She performed her PhD at the Hebrew University of Jerusalem and her postdoctoral training at the Harvard Medical School and Broad Institute. Since establishing her research team, Levy received the ERC Consolidator Award, the Rector and Dean Excellence in Teaching Awards, and the International Young Melanoma Investigator Award of the Society of Melanoma Research .

https://carmitlevylab.com /

Cancer development and other side of UV exposure

The human body takes different measures in order to protect itself against the results of UV exposure and its accompanied hazards, such as skin cancer Despite extensive studies regarding the molecular regulation of the two main UV protection mechanisms, namely, the DNA repair system and the pigmentation system, a comprehensive theory that simultaneously accounts for the two systems is still missing . We aim to elucidate, for the first time, the dynamic control used to schedule and synchronize the UV protection subsystems . Furthermore, melanoma is the most lethal skin cancer It is also a preventable cancer with the most rapid increase in its incidence Although the majority of patients are diagnosed in the early phase of disease, about 10 % of patients will develop systemic disease and succumb to it. Checkpoint inhibitors (CPIs) and targeted agents (TAs) have had a tremendous impact on this disease’s course We aim to find biomarkers for melanoma treatment response and to further dissect their mechanism of action, in order to enhance the effectiveness of immunotherapy