Development, Aging and Regeneration

Dr. Daniel Bar

Molecular biology of aging

Aging is the major risk factor for many prevalent diseases in the developed world, including cancer, diabetes and cardiovascular disease Systemically slowing the aging process has been shown to delay the onset of many diseases and prolong healthspan and lifespan in multiple model organisms We now know of metabolic and pharmacological interventions that slow aging, and of epigenetic modifications that correlate with aging with

Dr. Bar is a principal investigator at the School of Dental Medicine. Dr. Bar earned his bachelor’s degree in physics and biology from Tel Aviv University. He later went on to complete his PhD in Genetics at the Hebrew University of Jerusalem in the lab of Prof. Gruenbaum . Here, Dr. Bar worked on the nuclear lamina and lifespan regulating pathways in C. elegans . He continued to a visiting -fellow position in the lab of Dr. Francis Collins at the National Human Genome Research Institute, the National Institutes of Health, USA. He worked on proximity labeling, focusing on the nuclear lamina in primary human samples. He serves as guest editor of JOVE . https:// barlabtau.wixsite.com /website exceptional accuracy. However, the molecular details of these interventions, as well as natural aging, are only partially known The Bar lab develops new tools and applies them to study the molecular changes that accompany aging . These include using antibodies and various enzymes to label proteins, DNA and RNA and analyze them using highthroughput methods

Development, Aging and Regeneration

Prof. Dafna Benayahu

Stem cell metabolism & tissue regeneration

Prof. Benayahu’s research has two arms ; one is on mesenchymal stem cells (NSCs) differentiation and related pathophysiology of skeletal and fat tissues The mesenchymal cells are the main regulators of immune cells in the bone marrow and in fat tissue . The role of MSCs in aging and diseases is due to their capacity to convert into lipid -accumulating fat cells . Various pathways serve as cues in the niche

Prof Benayahu is at the Department of Cell and Developmental Biology and the Director of the Marian Gertner Institute for Medical Nano -systems . She is currently the President of the Israel Calcified Tissue . Society She has served as head of the Department and of the Nomination Committee at the Faculty of Medicine . Prof. Benayahu’s research is funded by the US -Israel Binational Science Foundation, the Israel Science Foundation, the Ministry of Health, the Ministry of Science, and the Ministry of Commerce . She has served as editor of a book, guest editor on special issues and reviewer for numerous international journals. https: //benayahulab. wixsite . com/benayahudafnatau regulating stem cell differentiation . The lab also uses mesenchymal stem cells (MSC) for various clinical applications such as immunomodulatory therapies and in cell replacement therapies application related to metabolic disease and tissue regeneration