Development, Aging and Regeneration

Prof. Yankel Gabet

Bone health & cannabinoids

Did you know that the skeleton is the largest organ by weight? Did you know that critical steps of immune cell development occur in the bone marrow? How do immune cells affect bone health? Can bone cells regulate our immune system? How can we suppress inflammationinduced bone destruction? Do specific strains of bacteria in our gut have an impact on the strength of our bones? Why do our bones weaken with age? Our main focus is on bone health and the crosstalk between bone and immune cells We developed unique models for the assessment of osteoporosis, inflammation -induced bone destruction and bone microarchitecture in response to modulations in the gut microbiota . Our therapeutic approaches include cannabinoids, antiinflammatory and bone anabolic agents that can modulate the boneimmune axis Our research spans from molecular biology to in vivo settings and we developed unique tools in 3 D models using microCT.

Prof. Gabet, D.M.D., Ph.D., is the Head of the Department of Anatomy & Anthropology and Director of the Bone Research Laboratory. He completed his post-doctoral training at the University of Southern California. He received several awards including the ASBMR Young Investigator award. He serves as treasurer of the Israeli Society for Skeletal Biology and Medicine. He is also a dentist focusing on implantology and oral rehabilitation and a consultant and scientific advisor for companies in dentistry, orthopedics and cannabinoids.