Development, Aging and Regeneration

Dr. Chen Luxenburg

Cytoskeletal regulation of epidermal stem cells

One of the significant challenges in biomedical research is to understand how stem cells give rise to functional tissue during development, maintain it throughout life, and regenerate it upon wounding The Luxenburg lab studies how cytoskeleton -derived signals regulate stem cells function We use the skin epidermis as our primary https://www.luxenburglab.com / model system, and studies in the lab provide insight into both skin development and common skin diseases such as cancer and psoriasis .

Dr. Luxenburg completed his Ph.D. studies in Molecular and Structural Cell Biology at the Weizmann Institute of Science. For his post -doctoral training, he trained at the laboratory of Prof. Elaine Fuchs at the Rockefeller University in New York. Dr. Luxenburg is the recipient of a number of research grants and awards, including the ISF, I-CoRE , BSF, ICRF, and the Teve founders prize. Dr. Luxenburg serves on the scientific board of the Israeli Society of Developmental Biology, Switzerland Institute of Developmental Biology, and the Biomed@TAU Developmental Research Hub. He is also the academic coordinator of the International Graduate program.

Development, Aging and Regeneration

Prof. Ronen Zaidel-Bar

Cytoskeletal regulation

A developing embryo taking shape, a heart pumping blood, and a wound closing itself all rely on mechanical forces to accomplish their important tasks . A special cellular machinery, the cell's skeleton, is responsible for generating these forces, but how this machinery is assembled at the right time and place in our bodies remains poorly https://www.zaidelbarlab.com / understood Prof Zaidel Bar's group is using cutting edge genetics and live -imaging microscopy in human and nematode models to gain a "front row seat" view of what the cytoskeleton is doing inside an animal A better understanding of cytoskeleton regulation is important to prevent birth defects and to treat numerous diseases, such as asthma, hypertension, and cancer metastasis

Prof. Zaidel -Bar, PhD, is head of the Department of Cell and Developmental Biology at the School of Medicine. He completed his Ph.D. in Molecular Cell Biology at the Weizmann Institute and post-doctoral training at the University of Wisconsin - Madison. He started his independent group at the Mechanobiology Institute, National University of Singapore, where he was awarded the National Research Foundation Fellowship, and seven years later he joined Tel Aviv University. Zaidel -Bar is a world leader in the field of cell and tissue mechanobiology.

Actin (green) and myosin (red) in the cortex of a C. elegans 1-cell embryo form a contractile belt that drives the first cell division. Wei-Yung Ding, ZaidelBar.