ABSTRACTS
Measures to reduce the clinical need for dental amalgam: an evidence review Keane, M., Lee, C., Long, J. International binding agreements oblige signatories, including Ireland, to reduce their use of mercury to protect the environment. In response, the Irish Government needs to phase out the use of dental amalgam by 2030. The aim of this evidence review was to examine factors relevant to phasing out of amalgam and consider alternative replacement strategies for treating dental caries. We examined evidence where: a) exemptions existed to allow the use of dental amalgam; and, b) measures taken to phase out amalgam. We also drew on 101 systematic reviews to identify alternative interventions to amalgam and their effectiveness. We found that exemptions to permit the continued use of amalgam only applied when treating permanent tooth restoration. Measures to phase out dental amalgam ranged from raising public awareness of the risk to the environment, to realigning dental insurance policies to prioritise alternatives to amalgam. There is adequate evidence that: a) fluoride technologies and resin-based sealants are effective in preventing dental caries; and, b) silver diamine fluoride, sealants combined with fluoride, and microinvasive strategies are effective in early treatment of caries. Glass-ionomer cements are equal to other restorative materials for restorations in primary teeth. Composite resin formulations are considered the next best restoration alternative to amalgam. Health Research Board, 2020. Available from: https://www.hrb.ie/fileadmin/2._Plugin_related_files/Publications/2020_pu blicationrelated_files/2020_HIE/Measures_to_reduce_the_clinical_need_for_dental_a malgam.pdf.
vaccine remains of overall benefit, based on the current available data. Singapore Medical Journal 2021. DOI: 10.11622/smedj.2021210. Epub ahead of print. PMID: 34808708.
Visualizing in deceased Covid-19 patients how SARSCoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb Khan, M., Yoo, S.J., Clijsters, M., Backaert, W., Vanstapel, A., Speleman, K., et al. Abstract Anosmia, the loss of smell, is a common and often the sole symptom of Covid19. The onset of the sequence of pathobiological events leading to olfactory dysfunction remains obscure. Here, we have developed a post-mortem bedside surgical procedure to harvest endoscopically samples of respiratory and olfactory mucosae and whole olfactory bulbs. Our cohort of 85 cases included Covid-19 patients who died a few days after infection with SARS-CoV-2, enabling us to catch the virus while it was still replicating. We found that sustentacular cells are the major target cell type in the olfactory mucosa. We
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A review of Covid-19 vaccination and the reported cardiac manifestations Ho, J.S., Sia, C.H., Ngiam, J.N., Loh, P.H., Chew, N.W., Kong, W.K., et al. Abstract In Singapore, 9.03 million doses of the mRNA Covid-19 vaccines by PfizerBioNTech and Moderna have been administered, and 4.46 million people are fully vaccinated. An additional 87,000 people have been vaccinated with vaccines on the World Health Organization’s emergency use listing. The aim of this review is to explore the reported cardiac adverse events associated with different types of Covid-19 vaccines. Some 42 studies that reported cardiac side effects after Covid-19 vaccination were included in this study. Reported Covid-19 vaccine-associated cardiac adverse events were mainly myocarditis and pericarditis, most commonly seen in adolescent and young adult male individuals after mRNA vaccination. Reports of other events such as acute myocardial infarction, arrhythmia and stress cardiomyopathy were rare. Outcomes of post-vaccine myocarditis and pericarditis were good. Given the good vaccine efficacy and the high number of cases of infection, hospitalisation and death that could potentially be prevented, Covid-19
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Journal of the Irish Dental Association | Dec 2021/Jan 2022: Vol 67 (6) 351