life sciences
WHAT WE DO We help clients save time and money, while improving the effectiveness of new solutions. We work with companies of every size – from startups exploring new ideas to multinationals – and at all levels of expertise and adoption in modeling and simulation, and from across a range of specialties, such as developers of class I-III medical devices, packaging, protective devices for sports and more.
OUR EXPERTISE INCLUDES: Virtual Bench Testing Adopting best practices from ASME V&V to develop simulated bench tests that can supplement and improve the value of physical testing and speed regulatory approval. Physical Testing Fully integrated test service with custom test fixture design and fabrication, along with comprehensive instrumentation fitting and monitoring. Parametric Studies & Optimization Understanding the effects of various parameters – additive manufacturing process variables or material property variations, for example – to develop optimal solutions. Automation Capturing and delivering best practices, methods and workflows in an automated fashion to improve productivity and reuse for future designs. Virtual Clinical Trials Applying the latest virtual human and animal modeling techniques to improve the effectiveness and design of pre-clinical and clinical trials, and to advance progress toward virtual (in silico) trials.
For the latest on our expanding service portfolio, visit thorntontomasetti.com/lifesciences.
www.thorntontomasetti.com
life sciences
VIRTUAL HUMAN MODELING (VHM) Our experts in digital modeling and biomechanics develop and deploy innovative techniques for simulating the human body and interactions between organs and various devices. When coupled with statistical methods and rigorous validation and verification principles, VHM expedites development of medical devices, wearable electronics and other products that must interact well with the human body to be successful.
HEART
SKIN
We simulate the behavior of cardiovascular devices – stents, valves and rings – not only to supplement bench tests, but also to study their interaction with virtual models of the heart, providing insight into how they will perform in real patients.
New drug types and the increase of self-administered treatments are driving innovative delivery methods. Realistic modeling of skin and underlying tissues enables virtual testing, a faster, less expensive and more detailed supplement to traditional physical testing.
SCALABLE HUMAN MODELS While some applications require precise representations of specific organs, scalable models provide better value when full detail isn’t needed. We are collaborating with various partners to use a library of human models at varying scales to cover the full spectrum of client needs.
MODELING TECHNIQUES & CAPABILITIES • Imaging-Based Model Generation • Material Model Development & Calibration • Approximations & Fast Running Models (FRM) • Parametric, Shape & Topology Optimization • Uncertainty & Probabilistic Assessments • Advanced Visualization & Virtual Reality (VR) • Machine Learning & Artificial Intelligence
We developed automated methods to adjust the Living Heart finite element model (reverse) to better match real-world observed behavior. These methods allow the virtual assessment of the effectiveness of cardiovascular devices (such as that shown at left) and treatment options.
SIMULATION DOMAINS • Solids & Structures
• Electromagnetics
• Fluids
• Biological Systems
• Acoustics (Shock & Vibration)
• Coupled Multiphysics
• Heat Transfer
• Multiscale Systems
Our simulations of needle-skin interactions and perfusion of drugs through tissue help assess efficacy of drug-delivery mechanisms and can facilitate selection of needle type and drug-delivery location and rate to maximize effectiveness and reduce pain.