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Urological Tumours
Urethra (ICD‐O‐3 C68.0, C61.9) Rules for Classification The classification applies to carcinomas of the urethra (ICD‐O C68.0) and transitional cell carcinomas of the prostate (ICD‐O C61.9) and prostatic urethra. There should be histological or cytological confirmation of the disease. The following are the procedures for assessing T, N, and M categories: T categories Physical examination, imaging, and endoscopy N categories Physical examination and imaging M categories Physical examination and imaging
Regional Lymph Nodes The regional lymph nodes are the inguinal and the pelvic nodes. Laterality does not affect the N classification.
TNM Clinical Classification T – Primary Tumour TX Primary tumour cannot be assessed T0 No evidence of primary tumour
Urethra (male and female) Ta Non‐invasive papillary, polypoid, or verrucous carcinoma Tis Carcinoma in situ
T1 Tumour invades subepithelial connective tissue T2 Tumour invades any of the following: corpus spongiosum, prostate, periurethral muscle T3 Tumour invades any of the following: corpus cavernosum, beyond prostatic capsule, anterior vagina, bladder neck (extraprostatic extension) T4 Tumour invades other adjacent organs (invasion of the bladder) Urothelial (transitional cell) carcinoma of the prostate Tis pu Carcinoma in situ, involvement of prostatic urethra Tis pd Carcinoma in situ, involvement of prostatic ducts
T1 Tumour invades subepithelial connective tissue (for tumours involving prostatic urethra only) T2 Tumour invades any of the following: prostatic stroma, corpus spongiosum, periurethral muscle T3 Tumour invades any of the following: corpus cavernosum, beyond prostatic capsule, bladder neck (extraprostatic extension) T4 Tumour invades other adjacent organs (invasion of the bladder or rectum)
N – Regional Lymph Nodes NX N0 N1 N2
Regional lymph nodes cannot be assessed No regional lymph node metastasis Metastasis in a single lymph node Metastasis in multiple lymph nodes
M – Distant Metastasis M0 No distant metastasis M1 Distant metastasis
pTNM Pathological Classification The pT and pN categories correspond to the T and N categories. For pM see page 8.
Stage Stage 0a Stage 0is Stage I Stage II Stage III Stage IV
Ta Tis T1 T2 T1, T2 T3 T4 Any T Any T
N0 N0 N0 N0 N1 N0, N1 N0, N1 N2 Any N
M0 M0 M0 M0 M0 M0 M0 M0 M1
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Urological
Urethra