2023-2024 JABSOM Department of Medicine Report

ALOHA FROM THE CHAIR.

DEPARTMENT LEADERSHIP

DOM BY THE NUMBERS

OUR FACULTY

FACULTY BY DIVISION

FACULTY HIGHLIGHTS

DIVISION HIGHLIGHTS

MEDICAL STUDENT EDUCATION

GRADUATE MEDICAL EDUCATION

UNIVERSITY OF HAWAI'I INTERNAL MEDICINE RESIDENCY PROGRAM (UHIMRP)

UNIVERSITY OF HAWAII PRIMARY CARE INTERNAL MEDICINE RESIDENCY PROGRAM (UHPC)

CARDIOVASCULAR DISEASE (CVD) FELLOWSHIP PROGRAM

COMMUNITY ENGAGEMENT

PAPAKOLEA ‘OHANA HEALTH FAIR

AMERICAN COLLEGE OF PHYSICIANS (ACP) HAWAI'I CHAPTER

ELIZABETH "LIZ" KEALI'IKUA'AINA TAM, M.D. MEMORIAL AWARD

RESEARCH ENDEAVORS

CENTER FOR CARDIOVASCULAR RESEARCH (CCR)

HAWAI'I CENTER FOR AIDS (HICFA)

UNIVERSITY OF HAWAI'I MAGNETIC RESONANCE RESEARCH CENTER (UHMRRC)

PHILANTHROPY

JOHN C. COUCH FUND FOR HEPATOLOGY AND ENDOWED CHAIR IN HEPATOLOGY.

ALOHA FROM THE CHAIR

Welcome from the JABSOM - UH Department of Medicine!

As we embark on another academic year, it is a great time to reflect on all that we accomplished in AY 2024 to prepare the foundation for AY 2025.

Of the many achievements we had, I am proud to announce the first class of new primary care IM residents in our brand-new UHPC training program. Much work led to this moment and I cannot thank enough all the individuals who contributed to making this vital new program a reality. We are well on our way to submitting our UH GI Fellowship application as well.

All of our important contributions to our UH-sponsored training programs, new initiatives and improvements are owed to our department funding. I am most grateful and thrilled to have received two enormously generous endowments from two gracious donors on behalf of our department. Mr. John Couch endowed a Chair in Hepatology and funds to start a new fellowship in GI/ Hepatology. Dr. Ken and Gemie Arakawa endowed the Chair of Medicine. Several faculty also contributed funds to the DOM Enhancement Fund and Dr. Elizabeth Tam fund. All of your generosity and large endowments will allow our department to grow and prosper in the future.

SCOTT K. KUWADA, MD, AGAF, FACP PROFESSOR AND CHAIR GASTROENTEROLOGY DIVISION CHIEF

KEN AND GEMIE ARAKAWA ENDOWED CHAIR OF MEDICINE

Our dedicated and committed faculty deserve pathways to academic progression. This begins with facilitating scholarly activities to enhance advancement in academic rank. Retaining Dr. David Easa, Emeritus Professor of Pediatrics, has been instrumental in educating our departmental leaders in constructing outstanding and persuasive promotion dossiers. Expanding research opportunities is vital to accelerating faculty promotions and careers. To this end, Dr. Cecilia Shikuma has garnered NIH funding that will soon allow access to clinical data at QMC and HPH. She has worked tirelessly with Dr. Todd Seto at QMC and Dr. Venkataraman Balaraman at HPH to implement new software that will finally catalyze clinical research.

Finally, we look forward to our new Dean - Dr. Sam Shomaker, whom I’ve known since medical school and our overlapping years at the University of Utah. We welcome him with excitement for all the experience as a Dean of Medicine at other schools as we thank Dr. Jerris Hedges for all his years as Dean here.

Your voice is important and I encourage you to make your thoughts and opinions through our Department of Medicine faculty meetings and over email.

Mahalo Nui Loa!

Scott

DEPARTMENT LEADERSHIP

cott K. Kuwada, MD

rofessor and Chair

Dominic Chow, MD, PhD, MPH

Professor and Associate Chair of Research

Reid Ikeda, MD

Associate Professor and Associate Chair of GME

Associate Chair of UME - TBA

2023-2024

554 4

CCOMPENSATED OMPENSATED

VVOLUNTEER OLUNTEER STAFF

55 TEAM MEMBERS TEAM MEMBERS

112 2 PPROMOTIONS ROMOTIONS

55 EEMERITUS MERITUS PPROFESSORS ROFESSORS

111 1 FFELLOWS ELLOWS

PHILANTHROPY

NEW ENDOWED NEW ENDOWED CHAIRS OF CHAIRS OF MMEDICINE EDICINE AND HEPATOLOGY AND HEPATOLOGY

$$5.768M 5.768M RESEARCH 1152 52

662 2 DDONORS ONORS

$$3.07M+ 3.07M+

IIN N GRANT FUNDING GRANT FUNDING RECEIVED THIS RECEIVED THIS ACADEMIC YEAR ACADEMIC YEAR

Gary Ahn, MD

Kristie Akamine, MD

Nobuhiro Ariyoshi, MD

Wint Aye, MD

Lopa Basu, DO

Henry Cacanindin, MD

Bo Yin Chang, MD

Christina Chong, MD

Wayne Chun, MD

John Chung, MD

Irina Crook, MD

Larry Day, MD

Serena Del Mundo, MD

Gautam Deshpande, MD

Mai-Linh Frascarelli, MD

Michael Furlong, MD

Larissa Gonzalez Medina, MD

Ashish Goyal, MD

Joanna Griffin-Boyce, MD

Julianne Griswold, DO

GENERAL ME

Francisco Halili , MD

Catherine Ho, MD

Ryan Honda, MD

Daniel Hong, MD

Dorothy Iwanski, DO

Christine Janke, MD

Susannah Jensen, M

Janet Kao, MD

Diana Kim, MD

Miki Kiyokawa, MD

Jason Kuniyoshi, MD

Christopher Kwock,

Jatinder Lachar, MD

Ynhu Le, MD

Garson Lee, MD

Qi Jie Nicholas Leo, M

Henry Lew, MD

Kuo-Chiang Lian, MD

Yuree Lin, MD

Sandra Loo, MD

Van Luu, MD

Thomas Maglinao, MD

Monica Mau, MD

Francisco Mercado Jr, MD

Fatema Merchant, MD

John Misailidis, MD

Keisuke Miyamoto, MD

Chi-Cheng Morehead-Yang, MD

Stuart Nakamoto, MD

Kelly Nakamura, MD

Toni Narimasu, MD

Paul Nho, MD

Jennifer Nishioka, MD

Masayuki Nogi, MD

Neil Onizuka, MD

Robert Pangilinan, MD

Ronald Pangilinan, MD

Dawn Peterson, DO

Jason Pirga, MD

Malia Ramirez, MD

ACULTY

Young Soo Rho, MD

Makiko Sawada, MD

Hannah Schmitz, MD

Kenneth Schwab, MD

Royce Shimamoto, MD

Helen Sim, MD

Harleen Singh, DO

David Spinks, MD

Alison Tamiya, MD

Aileen Tamura, MD

Lisa Tan, MD

Raquel Tello, MD

Richa Varshney, MD

Alena Velasco-Hughes, MD

Christine Wang, MD

Travis Watai, MD

Jordan Winston, MD

Stephanie Yoshimura, MD

Satomi Zukeran, MD

Rachel Ackerman, MD

Julie Andrada, MD

Timothy Au, MD

Lisa Barville, MD

Steven Brauer, MD

Bryan Brown, MD

Francis Buto, MD

Lisa Camara, MD

Boyuan Cao, MD

Dee-Ann Carpenter, MD

Li-Hsieh Chen, MD

Hausen Cheong, MD

Baron Ching, MD

Keila Ching, MD

Chelsea Ching-Endow, MD

Hisami Chock, MD

Chisoo Choi, MD

Dominic Chow, MD

Bradley Chun, MD

Carrie Colmenares Roys, MD

Roui De Castro , MD

Anne Dempsey, MD

Stephen Denzer, MD

Emily Diep, MD

Maegan Doi, MD

Nathaniel Enriquez, MD

Clayton Everline, MD

Yue Fang, MD

Janice Fong, MD

GENERAL MEDICINE - PRIMARY CARE

Victoria Fox-Behrle, MD

Braxton Fukutomi, MD

Rebecca Gelber, MD

Alison Goo, MD

Amanda Haley, MD

Nicole Higa-Leong, MD

Scott Himeda, MD

Aaron Hoo, MD

Gregory Howick, MD

Birendra Huja, MBBS

Noriko Hunter, MD

Malissa Iida-Takashima, MD

Michael Jackowitz, DO

Elliot Kalauawa, MD

Florence Kan, MD

Jennifer Katada, MD

Misao (George) Kawamura, MD

Kelly Kawaoka, MD

Naomi Karlen, MD

Kenneth Kepler, MD

Elizabeth Kiefer, MD

Claudine Kimura, MD

Katherine Kingsley, MD

Christian Kitamura, MD

Elizabeth Koehler, MD

Jeremy Kort, DO

Dane Kurohara, MD

Todd Kuwaye, MD

Sandy Liang, MD

Mark Lum, MD

George Macris, MD

Anthony Magliulo, MD

Robin Matsukawa, MD

Bryan Matsumoto, MD

Michael Mihara, MD

Nobuyuki Miki, MD

Kenneth Minami, MD

Nani Morgan, MD

Ashley Morisako, MD

Aaron Morita, MD

Ronald Morton, MD

Mitchell Motooka, MD

Travis Nakamura, MD

Mark Nishihara, MD

Hisami Oba, MD

Stephen Oishi, MD

Reese Omizo, MD

Janet Onopa, MD

Vanessa Osedo-Bleecher, MD

Abhinetri Pandula, MD

Stefanie Park, MD

Mary Paul, MD

Elizabeth Quinn, MD

Glenn Rediger, MD

Tara Reed, MD

Aldrich Alden Ricalde, MD

Macario Rivera, Jr., MD

Daniel Saltman, MD

Florian Sattelmacher, MD

Scott Serrano, MD

Robin Seto, MD

Craig Shikuma, MD

Anthony Siu, MD

Matthew Slavin, MD

Lisa Sodetani, MD

John Taitano, MD

Brandon Takase, MD

Marissa Takase, MD

Bryce Tanaka , MD

Dawn Taniguchi, MD

Eugene Tareshawty, MD

Sydney Tatsuno, MD

Nadine Tenn Salle, MD

Maria Termulo, MD

Fred Uhrle Jr., MD

John Vaz, MD

Laura Wong, MD

Lydia Wong Takazawa, MD

James Yess, MD

DERMATOLOGY

John Boyer, MD

Kevin Dawson, MD

Wayne Fujita, MD

CARDIOLOGY

Omar Abdul Ghani, MD

Michael Aldridge, MD

Hiroshi Ashikaga, MD

Steven Azuma, MD

Ramy Badawi, MD

Denny Bales, MD

Dipanjan Banerjee, MD

Giselle Baquero Caranama, MD

William Boisvert, MD

Michael Brodsky, MD

Michael Chan, MD

Sanah Christopher, MD

John Cogan, MD

Samuel Dacanay, MD

Ammaar El Sergany, MD

Osamu Fukuyama, MD

Paul Ho, MD

Randolph Hutter, MD

Panupong Jiamsripong, MD

John Kao, MD

Kris Kawamoto, MD

Anne Kemble, MD

Zia Khan, MD

Alan Kuo, MD

Helaine Kwong, MD

Carol Lai, MD

Luke Lam, MD

Rachel Lee, MD

Nath Limpruttidham, MD

Issac Mizrahi, MD

Jesus Pino Moreno, MD

Abdulelah Nuqali, MD

Benjamin Plank, MD

Kimble Poon, MD

Alamelu Ramamurthi, MD

Kahealani Rivera, MD

Kevin Salire, MD

Michelle Seidel Tallquist, M

Todd Seto, MD

Neal Shikuma, MD

Ralph Shohet, MD

David Singh, MD

Andrew So, DO

Michael Tanoue, MD

Rayji Tsutsui, MD

Margo Vassar, MD

Mahdi Veillet-Chowdhury, M

Sekon Won, MD

GASTROENTERLOGY

Christopher Aoki, MD

Daniel Chan, MD

Larissa Fujii-Lau, MD

Daryl Fujiwara, MD

John Garvie, MD

James Grobe, MD

Nour Hamade, MD

Shilpa Jain, MD

Ankur Jain, MD

Robert Jao, MD

Scott Kuwada, MD

Herbert Lim, MD

Kristi Lopez, MD

Joseph Manlolo, MD

Traci Murakami, MD

Dylan Lee, MD

Christopher-Allan Lum, MD

Joseph McKinlay MD

Fernando Ona, MD

Mel Ona, MD

Gavin Park, MD

Anahita Rezaie, MD

Tomoki Sempokuya, MD

Neal Shimoda, MD

Jennifer Tamai, MD

Chuong Tran, MD

Naoky Tsai, MD

Matthew Tsushima, MD

Russell Yang, MD, PhD

Brandon Yim, MD

Craig Young, MD

HEMATOLOGY/ ONCOLOGY

Jared Acoba, MD

Jeffrey Berenberg, MD

Matthew Chase, MD

Jami Fukui, MD

Jon Fukumoto, MD

Brian Issell, MD

Jodi Kagihara, MD

Kaye Kawahara, MD

William Loui, MD

Gordon Nakano, MD

INFECTIOUS DISEASE

Erlaine Bello, MD

Joel Brown, MD

Sharon Chi, MD

Heath Chung, MD

Tarquin Collis, MD

Jonathan Dworkin, MD

Louie Gangcuangco, MD

John Raymond Go, MD

Heidi Hillesland, MD

NEPHROLOGY

Thomas Aldan, MD

Rossini Botev, MD

Shiuh-Feng Sherwin Cheng, MD

Troy DeNunzio, DO

Chuong (Jason) Dinh, DO

Rick Hayashi, MD

Ana Hernandez, MD

James Ireland, MD

Christie Izutsu, MD

Mary Kingma-Noland, MD

Ryon Nak

Elizabeth

Kenneth S

David Tam

Naoto Uen

Nicolas Vi

NEUROLOGY

Stacy Brown, MD

Michiko Bruno, MD

Monique Canonico, MD

Vivian Chin, MD

Pola Chojecka, MD

Abraham Chyung, MD

Karen DaSilva, MD

Todd Devere, MD

Alexandra Galati, MD

Fay Gao, MD

Brandon Hirota, MD

Eric Kajio

Sarah Kem

Joseph Ko

Doanh Lu

Francis Pi

Brian Pien

Cecilia Sh

Benjamin

Royden Y

Brian Lee

Christoph

David Na'

Kunal Par

Chintav Sh

Carmen S

Jared Sug

Thomas T

Kalani Ya

Linda Jaffe , MD

David Kaminskas, MD

Kevin Kimata, MD

Matthew Koenig, MD

ChristopherKurahashi,MD

KoreLiow,MD

JeffreyLiu,MD

MichaelLui,MD

JeffreyMiles,MD

KarenMorgenshternYacoby,MD

Kazuma Nakagawa, MD

Beau Nakamoto, MD

Stuart Pang, MD

PAIN AND PALLIATIVE CARE

Ilan Bernstein, MD

Michael Duick, MD

Viren Patel, MD

Katherine Podraza, MD

Ray Romero, MD

George Ross, MD

Peter Rossi, MD

Michael Russo, MD

RonySalem,MD

TerryShimamoto,MD

HuidyShu,MD

AlanStein,MD

Chung-HuanSun,MD

JasonViereck,MD

VictoriaWong,MD

MelvinWong,MD

MelvinYee,MD

PULMONARY/ CRITICAL CARE

Danilo Ablan, MD

Benjamin Berg, MD

Maythawee Bintvihok, MD

Nishal Brahmbhatt, MD

Christian Castaneda, MD

Hangyul Chung-Esaki, MD

Graham Cormack, MD

Eric Crawley, MD

Gehan Devendra, MD

Samuel Evans, MD

Christopher Fiack, MD

Alvin Furuike, MD

T. Scott Gallacher, MD

Emilio Ganitano, MD

Russell Gilbert, MD

Stephanie Guo, MD

Karin Halvorson, MD

Malcolm Haruno, MD

Donald Helman, MD

Hao Chih Ho, MD

Reid Ikeda, MD

Ryotaro Kato, MD

David Kim, MD

Jacqueline King-Jodoi, MD

Sailaja Kolli, MD

John Kot, MD

Sreenandh Krishnagopalan, MD

Marc Kruger, MD

Artur Krupa, MD

Neha Kumar, MD

Gary Kuniyoshi, MD

Jordan Lee, MD

Peter Lee, MD

Chunrong Lin, MD

Brent Matsuda, MD

Anthony Migura, MD

Janet Myers, MD

Angelina Narashima, MD

Jonathan Paladino, MD

Julius Pham, MD

Ryota Sato, MD

Bruce Soll, MD

Hiro Sung, MD

Brent Tatsuno, MD

Bradley Tokeshi, MD

Yash Trivedi, MD

Makoto Uchiyama, MD

Mark Valdez, MD

Phillip Verhoef, MD

Timothy Vossler, MD

Thomas Wong, MD

James Yang, MD

Roger Yim, MD

REHABILITATION MEDICINE

Cedric Akau, MD

Merle Mirua Akamine, MD

Nicholas Muraoka, DO

Jordan Wang, MD

OTHER

Marc Coel, MD

Christina Higa, PhD

Hyewon Jun, MD

Sandi Kwee, MD

Yuki Moritoki, MD, PhD

Sayaka Oikawa, MD

Gen Ouchi, MD

Christoph Rettenmeier, PhD

Eri Sato, MD

Scott Souza, PharmD

Victor Stenger, PhD

Wesley Sumida, PharmD

Kahoko Taki, MD

Zidan Yu, PhD

2023-2024 FACULTY HIGHLIGHTS

OMAR ABDUL GHANI, MD ASSISTANT PROFESSOR CARDIOLOGY

Selected to serve as Cardiovascular Disease Fellowship Program Director. Elected American College of Cardiology Hawaii Chapter Governor. Co-chaired the first ACC Hawaii Chapter Annual Meeting and presented research on “Microbubble Formation Following Mechanical Support with Impella CP Placement in Patients with Narrow Aortic Root”.

JARED ACOBA, MD ASSOCIATE PROFESSOR ONCOLOGY

Continued to serve as the UHIMRP Oncology Selective Coordinator. Advanced the phase II study of TSR-022 in combination with TSR-042 for the treatment of advanced hepatocellular carcinoma (PI) and the NCI Community Oncology Research Program (Co-PI). Co-authored six peer-reviewed publications, including "Racial and survival disparities in inflammatory breast cancer (IBC) and non-IBC: a population-based study focused on Native Hawaiians and other Pacific Islanders" (Front Oncol) and "Phase 3 Trial of Cabozantinib to Treat Advanced Neuroendocrine Tumors" (NEJM) which will establish a new standard of care for the treatment of neuroendocrine tumors. Collaborated on three abstracts, two of which were presented at the American Society of Clinical Oncology, Annual Meeting in Chicago, IL.

BENJAMIN BERG, MD PROFESSOR

PULMONARY/ SIM TIKI

Co-authored four peer-reviewed publications: “Response to Recovering From Adversity” (Simul Healthc), “A scoping review of remote facilitation during simulation-based healthcare education” (BMC Medical Educ), “Simulation Past, Present, and Future” (Clin Exp Emerg Med), and “Remote Facilitation in Simulation-Based Healthcare Education” (BMC Med Educ). Presented “AI Generated Simulation Scenarios” at SIMPACTS, Pakistani Simulation Society. Conducted two workshops and presented the poster “Family Presence During Resuscitation” at the International Meeting on Simulation in Healthcare (IMSH) and “Exploring Debriefing Quality” at the Health Professions Education Conference (HPEC). Mentored student research on “Generative AI vs. Faculty-Facilitated Simulation Design", also presented at HPEC. Conducted 8 Simulation-Based Healthcare Education (SBME) Faculty Development Programs at JABSOM and 10 International FD and Invited speaker programs. Elected as a Fellow in the Society of Simulation in Healthcare (SSH) Academy. Awarded SSH Presidential Citation for establishing the inaugural “Society of Simulation in Healthcare Asia-Pacific Evolution Summit“ (SHAPES) at JABSOM/SimTiki.

WILLIAM BOISVERT, PhD PROFESSOR CARDIOLOGY

Awarded funding by the American Heart Association for his research on perivascular adipose tissue in atherosclerosis. As a plenary speaker, presented at international conferences on metabolic syndrome, lipid disorder, and atherosclerosis.

DOMINICCHOW,MD,PHD,MPH PROFESSOR PRIMARY CARE

Continued to serve as an Investigator at the Hawaiʻi Center for AIDS (HICFA), Research Associate Chair, Resident Research Coordinator and Program Director for Ola HAWAII, a U54 RCMI Specialized Center. Advanced work on three extramural grants, leading as PI on "Administrative Supplements to Enhance Inclusion of Native Hawaiian/Other Pacific Islander Populations in Minority Health and Health Disparities Research" and Co-PI on the study "COVID19 Infection in Hawaii". Co-Presented "Neutrophil Activation and Their Derived Nets Contribute to Thrombotic Risk in Pulmonary PASC" at the 2024 Conference on Retroviruses and Opportunistic Infections (CROI) in Denver, CO and "Dysregulation of Neutrophil Phenotypes in Individuals with Pulmonary Post-Acute Sequelae of SARS-CoV2" at the 2024 RCMI Consortium National Conference in Washington, D.C. Received the 2024 Elizabeth “Liz” Kealiikuaaina Tam, M.D. Memorial Award, presented to a faculty member who emulates the passion, grace, leadership and the dedication of Dr. Tam.

GEHAN DEVENDRA, MD ASSOCIATE PROFESSOR PULMONARY/CRITICALCAREDIVISIONCHIEF

Promoted to Associate Professor. Continued to serve as the Critical Care Division Chief. As PI, advanced his NIH-funded study “Factors Responsible for the Development of Pulmonary Post-Acute Sequelae of SARS-CoV-2 Infection (PPASC) in Hawaii.” Collaborated on the publication “Single-cell RNA sequencing reveals characteristics of myeloid cells in pulmonary post-acute sequelae of SARS-CoV-2” (Front Immunol). Invited Speaker at the Washington Thoracic Society presenting "Multidisciplinary Approach to pulmonary hypertension care". Also as an invited speaker, presented “Disparities of Care in Respiratory Medicine” and contributed to five presentations at the American Thoracic Society 2024 International Conference in San Diego, CA. Presented on five other occasions, including the RCMI Conference in Bethesda, MD. Received funding from NIH for AIMAHEAD study as MPI "Integrative Analysis of Risk Prediction and Outcome Modeling in Lung Cancer using Machine Learning."

MIKI KIYOKAWA, MD ASSOCIATE PROFESSOR IM/ ADDICTION MEDICINE

Promoted to Associate Professor. Joined our UME leadership team as Associate Clerkship Director. Continued in her role as UHIMRP Addiction Medicine Fellowship Program Director educating not only UME but GME trainees in multiple departments. As Co-I, progressed her research on the study "Facilitators and barriers to implementation of a pilot methamphetamine treatment program at a Level I trauma center" and collaborated on another NIH-funded study. Authored four peer-reviewed publications, mentored all four and served as lead author on two. Gave two talks as an invited speaker at the The Nigerian Medical Association Quarterly CME event, Advancing Addiction Medicine and six other webinars. Co-author of an abstract at the American Society of Addiction Medicine 2024, Dallas, TX, which won the Best Student Research Award.

MATTHEW KOENIG, MD ASSOCIATE PROFESSOR NEUROLOGY

Selected to represent Hawaii with our U.S. Congressional delegation for Neurology on the Hill for the sixth consecutive year. Elected as Chair of the Hawaii Stroke Coalition. Advanced his research on the Telehealth Network Grant Program (PI) and the CDC Paul Coverdell Acute Stroke Program (Co-PI). Delivered the talk “Stroke Complications and Management” as an international guest speaker, in addition to presenting at seven other local events and webinars.

ALAN KUO, MD ASSISTANT PROFESSOR CARDIOLOGY

Joined our Cardiovascular Disease (CVD) Fellowship Training Program leadership as Associate Program Director. Gave an oral presentation entitled "Navigating Prevention and Treatment Options in Cardiovascular Disease: Focus on Coronary Artery Disease/Acute Coronary Syndromes and Atrial Fibrillation" at the Hawaii Pacific Gerontological Society.

SCOTT KUWADA, MD CHAIR AND PROFESSOR GASTROENTEROLOGY DIVISION CHIEF

Was appointed Ken and Gemie Arakawa Endowed Chair of Medicine. As Co-PI, secured NIH funding for his research "Facilitating Patient Success in Colorectal Cancer Prevention among Pacific Islanders" and advanced progress on "Five or Ten Year Colonoscopy for 1-2 NonAdvanced Adenomatous Polyps" as PI. Co-authored two publications: "miRNA as a Biomarker for the Early Detection of Colorectal Cancer" (Genes) and "Multiethnic Trends in Early Onset Colorectal Cancer" (Cancers). Presented at Digestive Disease Week in Washington, DC and, as Co-Director, spoke at the Clinical Updates in Gastroenterology at the Hepatology & Nutrition Hawaii CME Conference.

HELAINE KWONG, MD ASSISTANT PROFESSOR CARDIOLOGY

Joined our Cardiovascular Disease (CVD) Fellowship Training Program leadership as Associate Program Director. Continued in her role as UHIMRP Cardiology Subspecialty Education Coordinator.

BRENT MATSUDA, MD

ASSISTANT PROFESSOR PULMONARY/ CRITICAL CARE

Joined our leadership as the Director of Medical Education (DME) for Critical Care Medicine.

NANI MORGAN, MD ASSISTANT PROFESSOR PRIMARY CARE

Joined our leadership as the Ambulatory Director of Medical Education at Queen Emma Clinic, hoping to focus on curricular development in Quality Improvement and Health Equity. As an Ola Hawaii Pilot Project awardee, presented her research "The Kilolani Project: Addressing Health Disparities through Community Navigation Among Native Hawaiians with Diabetes" at the Research Centers in Minority Institutions Program Annual Conference in Bethesda, Maryland.

RYON NAKASONE, MD ASSISTANT PROFESSOR HEMATOLOGY/ ONCOLOGY

Began his duties as Governor Elect of the ACP Hawaii Chapter. Continued to serve as UHIMRP Recruitment Selection Chair and is also the President-Elect of the Hawaii Society of Clinical Oncology.

TODD SETO, MD, MPH VICE CHAIR AND PROFESSOR CARDIOLOGY

Continued to serve as Vice Chair of the Department of Medicine. Secured extramural funding as Co-PI for “Building and Implementing Data Capacity for Improving Quality and Equity at Queen’s (BUILD IQEQ)” and continued his work on four additional grants, including the Hawai’i Health Equity Research and Outreach Network (HAWAI’I HERON) and Hawaii Clinical Research Network for Health Equity. Authored four peer-reviewed publications, acting as first author on “Impact of More Detailed Measures of Disease Severity on Racial Disparities in Cardiac Surgery Mortality among Native Hawaiians and Pacific Islanders” (Hawaii J Health Soc Welf). Lead speaker on “Rheumatic Heart Disease and Mitral Valve Surgery in a Majority Minority Population in Hawaii” presented at JACC, contributed to two projects presented at the 2024 Noguchi Humanism, Empathy, Social Justice, and Global Health Symposium, and was part of the team to present at the American College of Graduate Medical Education 2024 Annual Educational Conference, Orlando, FL.

ROYCE SHIMAMOTO, MD ASSISTANT PROFESSOR HOSPITAL MEDICINE

Received the Wo Family Faculty Excellence Award, recognizing a clinical faculty member for exemplary qualities as chosen by the 4thyear class.

RALPH SHOHET, MD PROFESSOR CARDIOLOGY

Continued to serve as Director of the Center for Cardiovascular Research. Most important grant success was renewal of our Cardiovascular T32 Training Grant for another 5 years which supports three graduate students and three postdoctoral fellows each year. Co-authored the peer-reviewed publications "Vertebral tortuosity is associated with increased rate of cardiovascular events in vascular Ehlers-Danlos syndrome" (JAHA) and "Non-viral in vivo cytidine base editing in hepatocytes using focused ultrasound targeted microbubbles" (Mol Ther Nucleic Acids). In addition to mentoring two postdoctoral fellows and a graduate student in the lab I began teaching in PBL for the Cardiopulmonary course (MD 2).

DAVID SINGH, MD

ASSISTANT PROFESSOR CARDIOLOGY

Was promoted to Full Professor. Was part of the teams to author “High-Frequency Low-Tidal Volume Ventilation Improves Long-Term Outcomes in AF Ablation: A Multicenter Prospective Study” (JACC Clin Electrophysiol) and “Cliff diving leading to commotio cordis in a patient with Ebstein's anomaly” (J Cardiol Cases).

BRANDON TAKASE, MD ASSISTANT PROFESSOR PRIMARY CARE

Served on the UHIMRP leadership team as Firm Advisor for Firm Blue. Selected to serve as Core Faculty for the new UH Primary Care Internal Medicine Residency Program. Received the UHIMRP Faculty Award for Excellence in Teaching.

MICHELLE TALLQUIST, PhD

PROFESSOR CARDIOLOGY

Continued her research on four projects, serving as PI on three: “Regulation of Cardiac Inflammation by Fibroblasts” (NIH), “The Role of Lung Lipofibroblasts in Alveolar Differentiation” (NIH), and “Modeling SARS-CoV-2 Fibrosis Using a hACE2 Mouse Transgenic Model” (HCF). As an invited speaker, presented “Functional Consequences of Fibroblast Loss in Tissue Homeostasis and Disease” at the AHA Basic Cardiovascular Sciences Scientific Sessions in Boston, MA. Contributed to the peer-reviewed publication “LowDensity Granulocytes Display Immature Cells with Enhanced NET Formation in People Living with HIV” (Sci Rep).

JAMES YESS, MD

ASSISTANT PROFESSOR PRIMARY CARE

Assumed the role of UH Primary Care Internal Medicine Residency Program Director, with the subsequent development and curriculum build-out of this novel Primary Care focused Internal Medicine training program. Continued research in health disparities related to Native Hawaiian Health, and continued precepting Internal Medicine residents in Primary Care at Queen Emma Clinic, and mentoring/ precepting JABSOM Medical Students.

2023-2024

DIVISION HIGHLIGHTS

CARDIOLOGY

DIVISION OVERVIEW

The Cardiology Division is comprised of faculty from a comprehensive array of subspecialties, including general cardiology, interventional cardiology, electrophysiology, advanced cardiovascular imaging, advanced heart failure, and cardiovascular basic science and outcomes research. While we remain committed to enhancing and improving our Fellowship Program in Cardiovascular Diseases, we additionally focused on increasing our support of undergraduate medical education at JABSOM this year, as well as supporting faculty development to further promote a culture of education. Specific activities by the Division include:

UME AND GME

Initiating formal medical student mentorships with cardiology faculty.

Developing subspecialty rotations for medical students, particularly in Advanced Heart Failure and Electrophysiology.

Formal didactics for the medical students, including ECG interpretation and physical exam teaching. Mentorship for Project HEART, a medical student group designed to promote CPR in schools. Precepting for blood pressure screening in Chinatown by medical students.

Developing a comprehensive Cardiac CT/MR educational curriculum for the fellows.

Offering the MS4 Cardiology elective (MED 545-C).

FACULTY SPOTLIGHT

DIPANJAN BANERJEE, MD PROMOTED TO FULL PROFESSOR

Served on the American College of Cardiology Program Directors and Graduate Medical Educators council, and co-authored the council's statement on virtual vs in person interviewing for applicants to GME positions. Collaborated on four peer-reviewed papers, including "Withdrawal Of Atrioventricular Nodal Blocking Agents in Patients Receiving Mavacamten: A Retrospective Single-Center Experience in a Predominantly Asian-American Cohort" (Am J Cardiol). As a guest speaker, moderated the poster sessions at the American College of Cardiology conference in Atlanta, GA, and presented at two other national events. Presented "Managing Stage D Heart Failure Patients Outside of LVAD/Transplant Centers" at the International Society of Heart and Lung Transplantation Conference in Prague, Czech Republic.

FACULTY INITIATIVES

Drs. Seto and Banerjee were promoted to Full Professor. Dedicated monthly Cardiovascular Grand Rounds were started this year.

Hawai'i Cardiovascular Symposium, led by Dr. David Singh.

Participation in planning of ACHD CATCH (Caring for Adults and Teens with Congenital Heart Disease) Conference by Dr. Anne Kemble.

Initiation of the RIDGETrail Medical Education Certification Pathway for cardiologists on the inpatient teaching service.

Faculty serve as leaders local community organizations, including Dr. Vassar as Hawai'i American Academy of Cardiology President and Dr. Khan as Hawaii American Heart Association President.

ENDOCRINOLOGY

DIVISION OVERVIEW

Our endocrinology division is dedicated to the study and service of providing exceptional health care in the realm of hormone therapy. Endocrinologists focus on the treatments of diabetes, thyroid disorders, osteoporosis, adrenal, pituitary care, and transgender medicine, among other hormone related issues. Our division is comprised largely of clinical faculty who volunteer their time and expertise in our field. Faculty are practicing physicians distributed across our island at Queens Medical Center, Kaiser Hospital system, Hawaii Pacific Health hospitals, the Veterans Health Association (VHA) and in Private practice.

HIGHLIGHTS

Teaching electives in Endocrinology are available to medical students and residents at the Veterans Health Association clinics at the Spark Matsunaga VA Medical Center. Over the course of the year Endocrine elective is a 4 week subspecialty block open to UH medical students and residents and also Tripler Army Medical Center Residents.

In addition, specialty endocrine elective for internal medicine residents is also available at Hawaii Pacific Health Straub Hospital and Clinics.

Notable research has been done with special interest in the fields of diabetes and cardiometabolic differences in Asians, Pacific Islanders and Native Hawaiians.

Ongoing research is conducted in the field, including through partnerships with industry and public organizations. Notable studies include ongoing evaluation of the cardiovascular impacts of GLP-1 and GIP agents, as well as primary prevention studies at the VHA Clinics and in private practice at the East West Medical Research Institute.

DR. JOHN MELISH

FACULTY SPOTLIGHT

GASTROENTEROLOGY

HEPATOLOGY AND NUTRITION

DIVISION HIGHLIGHTS

The biannual

CLINICAL UPDATES IN GASTROENTEROLOGY, CLINICAL UPDATES IN GASTROENTEROLOGY, HEPATOLOGY AND NUTRITION IN HAWAII 2024 HEPATOLOGY AND NUTRITION IN

HAWAII 2024

co-sponsored by the University of Hawai’i and University of Utah, resumed at the Prince Hotel Waikiki after a four year hiatus due to COVID-19. The course emphasized addressing challenging clinical issues and the application of innovative techniques in gastroenterology, hepatology, GI imaging, and endoscopic procedures.

Transplant hepatologist

DR. CHUONG TRAN

commenced NIH funded research on metabolic associated liver disease as a junior investigator who will be mentored by Dr. Cecilia Shikuma, Dr. Todd Seto, and Dr. Scott Kuwada.

DR. TOMOKI SEMPOKUYA

was appointed as the second transplant hepatologist at QMC after completing residency through UHIMRP and GI transplant hepatology at the University of Nebraska.

DR. TRACI MURAKAMI

was promoted to Associate Clinical Professor of Medicine.

DR. ANKUR JAIN

continues as the Hawaii Chapter President of the American College of Gastroenterology.

HOSPITAL MEDICINE

FACULTY SPOTLIGHTS

UO-CHIANG LIAN, MD

ASSISTANT PROFESSOR

the UHIMRP Clinical Competency uthored the abstracts "The 'Other' and "Gastric Diffuse Large B cell g with Massive Gastrointestinal t Med). Collaborated on seven ng three at the national level: the y ernal Medicine Annual Meeting in Boston, MA; the Group on Student Affairs (GSA), Careers in Medicine (CiM), and Organization of Student Representatives (OSR) National Meeting in San Francisco, CA; and the ACGME Annual Educational Conference in Orlando, FL.

CHRISTINA CHONG, MD

SISTANT PROFESSOR

as faculty for teaching POCUS and Contributed to the peer-reviewed ersible Cerebral Vasoconstriction y g Eclampsia" (Cureus) and "Bilateral Renal Vein Thrombosis and Chylous Ascites in Phospholipase A2 Receptor-Associated Membranous Nephropathy" (Cureus). Supervised and reviewed three presentations and posters at the ACP Hawaii Chapter Meeting, as well as one poster at the ACP National Meeting in Boston, MA.

TRAVIS WATAI, MD ASSISTANT PROFESSOR

ntinued to serve as the UHIMRP Associate Program Director. Co-authored the ticle "Reversible Cerebral Vasoconstriction Syndrome Mimicking Eclampsia" ureus). Contributed to a case report presented by Dr. Weiming Du at the 2024 CP Hawaii Chapter conference, titled "A Case of Reversible Cerebral soconstriction Syndrome (RCVS) in an Eclamptic Patient", which won first ace. Co-founded the Clinician Educator Pathway for UHIMRP residents and itiated a medical education journal club for the QUMG Hospitalist Group. Was minated for the UHIMRP Faculty Award for Excellence in Teaching, as well as e 2024 Elizabeth “Liz” Kealiikuaaina Tam, M.D. Memorial Award.

NEUROLOGY

DIVISION OVERVIEW

The Neurology Division is comprised of general neurologists and subspecialized neurologists with fellowship training in clinical neurophysiology, epilepsy, headache medicine, movement disorders, neuroimmunology, neurocritical care, neuromuscular medicine, sleep medicine and vascular neurology. All of the division members participate in the medical student and/or resident teaching programs; and some actively participate in clinical research.

Noteworthy accomplishments including collectively, through the Hawaii Stroke Coalition, with partnership of all the major hospitals in Hawaii, the quality and performance outcome for acute stroke treatment was shown to be significantly better than the U.S. mainland stroke centers.

TEACHING

FACULTY SPOTLIGHT

KAZUMA NAKAGAWA, MD

NEUROLOGY DIVISION CHIEF PROMOTED TO FULL PROFESSOR

Continued to serve as Neurology Division Chief and UHIMRP Neurology Selective Coordinator. As first author, wrote "FOXO3 longevity genotype attenuates the impact of hypertension on cerebral microinfarct risk" (J Hypertens) and contributed to two other peer-reviewed publications. Progressed the study "Impact of APOE and FOXO3 Genotype on Hemorrhagic Stroke in Japanese–American Men."

As clinician-educators for the JABSOM medical students, residents and fellows, it is our obligation to inspire the students and trainees to become the future leaders of the field. Many of the division members participate in the Longitudinal Clinical Mentor program for the first and second-year medical students, as well as second-year medical students’ Clinical Skills Program during their Locomotor, Neurological, and Behavior System, 4th year inpatient and outpatient neurology elective, as well as Internal Medicine residents’ elective and selective rotations in outpatient and inpatient neurology.

COMMUNITY OUTREACH

Our division is extensively involved with community outreach efforts in Hawaii and works closely with American Heart Association/American Stroke Association, ALS Association, Epilepsy Foundation, Parkinson’s Foundation, Hawaii Neurological Society, Hawaii Parkinson Foundation, Hawaii State Department of Health and Hawaii Stroke Coalition.

RESEARCH

The Neurology Division’s overall research mission is to address health disparities among Native Hawaiians and other underserved populations with various neurological conditions. The Queen’s Neuroscience Research program has

1. a research study funded by the Michael J. Fox Foundation to assess disparities in care of Parkinson’s disease patients among Asian Americans, Native Hawaiians and Pacific Islanders,

2. NIH-funded multicenter study to assess disparities in blood pressure control and cognitive outcome among Native Hawaiians and Asians patients with intracerebral hemorrhage (REACH-ICH),

3. NIH/COBRE-funded study to investigate genetic determinants of cerebrovascular disease among multi-ancestral Hawaiian population.

Hawaii Pacific Neuroscience sponsors multiple medical students to participate in research through their Summer Research Internship program. Both Queen’s Neuroscience Research and Hawaii Pacific Neuroscience research programs participate in multiple Phase I, II, and III clinical trials for various neurological disorders.

STACY BROWN, MD

ASSISTANT PROFESSOR

FACULTY SPOTLIGHTS

Began her Phase II COBRE-Diabetes (PI) project on genetically determined diabetes and risk of stroke in the Multiethnic Cohort and continued her community-based participatory research

supported by a Hawaii Community Foundation Medical Research Grant (Co-PI). Authored four publications including primary and senior authorship of "Advancing Stroke Genetics in Hawai’i and the Pacific Islands" (Frontiers of Stroke) and "Fighter Pilot Syndrome: A Bow Hunter Syndrome Variant Identified with Dynamic Cerebral Angiography" (Stroke: Vascular and Interventional Neurology). She was primary or senior author of five abstracts presented at the national/international level and senior author of four abstracts presented on the regional level. As an invited speaker, she presented at the Neurocritical Care Grand Rounds at the University of Washington, the Annual CHEST Meeting, the Surfers Medical Association, and CME events for Hawaii Pacific Health and the Queen's Pediatrics Department.

J. DOUGLAS MILES, MD, PHD ASSISTANT PROFESSOR

Continued in his role as the UHIMRP Neurology Subspecialty Education Coordinator. Authored the peerreviewed publication "Five Recommendations to Foster a Love of Teaching" (Med Sci Educ) and authored eleven abstracts. Presented "What now? Clinical Reasoning in Electrodiagnostic Testing" at the American Association of Electrodiagnostic Technologists (AAET) Annual Conference 2023 in Austin, TX. Received the first Annual HMSA Center for Learning Innovation (CLI) Creative Pedagogy Award for the project “Streamlining the Generation of Neurology Exam Animations for Teaching and Assessment”.

NEW LEADERSHIP

HRISTIE IZUTSU, MD

SISTANT PROFESSOR PHROLOGY DIVISION CHIEF

FACULTY ADDITIONS

THOMAS JESSIE ALDAN, MD

NEPHROLOGY

DIVISION OVERVIEW

The Division of Nephrology is dedicated to excellence in patient care, education and clinical advancements in the field of nephrology. As providers, we collaborate to manage complex patients across the state with chronic kidney disease and a growing transplant center which serves the entire Pacific basin. As educators, we facilitate the nephrology rotations for students and residents, paving the way for future nephrologists.

The division consists of 16 board-certified nephrologists in private practice settings who partner with each of the major health care systems in the state. Together, we provide 24-hour coverage for both established and new patients in all high acuity settings, offering consultative services for conditions including acute kidney injury, end-stage renal disease management and transplant. Joining us this year are Drs. Thomas Jessie Aldan, Mary Kingma-Noland, and Chintav Shah. Notably, Drs. Ana Hernandez and Shiuh-Feng “Sherwin” Cheng were appointed to the paid faculty.

For the residency program, we offer a clinical rotation involving inpatient and outpatient management of a variety of renal diseases. Residents are supervised on an inpatient consultative service at Kuakini Medical Center and the Queen’s Medical Center. They also participate in hemodialysis & peritoneal dialysis rounds, CKD clinic and transplant clinic. There is also an opportunity to participate in clinical research and develop individualized clinical rotations. Similar offerings exist for fourth-year medical students interested in an in-depth two- or four-week experience in nephrology. Our division also provides didactic education at various conferences including grand rounds for the University and Transplant Center, Queen Emma Clinics, Scholarly Activities Session, MD3 and the surgery residency program.

Collectively, the division has published several papers in JASN and in collaboration with NKF to highlight the kidney health disparities for Native Hawaiians and Pacific Islanders, as well as the overall growing need for greater nephrology resources in the state. Work is ongoing in conjunction with the state’s federally qualified healthcare centers to promote culturally sensitive multidisciplinary care for CKD patients and with the medical school on strategies to address these needs.

CHINTAV SHAH, MD

ANA HERNANDEZ, MD

SHIUH-FENG “SHERWIN” CHENG, MD

MARY KINGMANOLAND, MD (MAUI)

2023-2024 | DIVISION HIGHLIGHTS | PULMONARY/ CRITICAL CARE

PULMONARY/CRITICAL CARE

DIVISION OVERVIEW

The Division of Critical Care Medicine spans multiple intensive care units (ICU) throughout Hawaii including staffing via virtual health to the Big Island and Kauai. We have staff that serves the ICUs at Queens Medical Center- Manamana, Queens Medical Center- West, Straub Medical Center, Pali Momi Medical Center, Kuakini Medical Center, and Kaiser Moanalua Hospital. We have a total of over 100 ICU beds between our hospitals and have a range of ICU services including medical intensive care, cardiac intensive care, medical and surgical critical intensive care, and also extracorporeal membrane oxygenation (ECMO). Over 7000 patients per year are admitted through our hospitals and treat a range of illness including septic shock, acute respiratory failure, pulmonary hypertension, heart failure, post cardiac arrest and post cardiac surgery. We also cannulate over 20 ECMO cases per year. The key staff of the simulation center at JABSOM is included in our faculty. Our faculty are a critical asset in the training of critical care medicine for multiple internal medicine and family medicine residency programs in Hawaii. Over the past year we have excelled in both clinical and academic endeavors. We continue to enroll patients into the ICECAP national trial, selected to begin TETON trial, continue to expand our NIH funded programs in Long COVID and genomics in lung cancer including the integration of artificial intelligence. Some of our faculty were voted on as the best educators of the year.

We have had multiple publications in several journals including JAMA, ATS Scholar, CHEST, Critical Care Medicine, Journal of Mechanical Ventilation and Frontiers in Immunology and as well as multiple presentations including invited talks at CHEST, American Thoracic Society, Washington, Hawaii, Alaska Thoracic Society, American Associate of Respiratory Care and American College of Cardiology. Our faculty also hosted an inaugural conference for the Society of Mechanical Ventilation. We have received GOLD recognition in Get with the Guidelines from American Heart Association 2 years consecutively. Our philosophy of educating future healthcare professionals, delivering high quality healthcare whilst conducting research to help translate that into practice is part of our ethos as a division.

FACULTY SPOTLIGHTS

EHAB DAOUD, MD ASSOCIATE PROFESSOR

Continued to lead as the Founder and President of the Society of Mechanical Ventilation, while also serving as the Editor-in-Chief of the Journal of Mechanical Ventilation. Presented his research at the Society of Mechanical Ventilation Conference and as an invited guest at Saitama Medical University in Japan. Recipient of the UHIMRP Faculty Award for Excellence in Teaching.

REID IKEDA, MD ASSOCIATE PROFESSOR

Continued to serve as the UHIMRP Program Director. Continued in his role as the American Lung Association of Hawaii and Leahi Fund Endowed Chair in Respiratory Health. Contributed to the abstracts and presentations "Predicting the Success of HFNC for Treating ARDS due to COVID-19: The role of Inflammatory Biomarkers" and "Serial Biomarker Measurements May be Helpful to Predict the Successful Application of High Flow Nasal Cannula (HFNC) in COVID-19 Pneumonia", held at the Annual CHEST Meeting and the American Thoracic Society 2024 International Conference in San Diego, LA. Recipient of the UHIMRP Teaching Excellence in the MICU Award.

MEDICAL STUDEN EDUCATIO

UME OVERVIEW

The John A. Burns School of Medicine (JABSOM)'s MD program is unique in its use of Problem-Based Learning (PBL) and Community-based Medicine. Students are trained in affiliated community hospitals and clinics, which gives them real-world experience from the start. Through PBL, our first and second year students are educated to think critically, to identify and define new information and learning issues by evaluating and researching data, and apply their new knowledge to the problem at hand. Our Departmental faculty hold key leadership and teaching roles in PBL and Longitudinal Clinical Preceptorship (LCP), mentoring students in clinical problem solving and effective communication with patients, their families, and other members of the health team. Third year students are introduced to the breadth and depth of Inpatient and Ambulatory Internal Medicine, the foundation for all clinical specialties. During their required Internal Medicine Clerkship, they receive supervised, formative experiences in the evaluation and management of patients, spending 4 weeks in an inpatient setting and a semester in an outpatient setting. Fourth year medical students rotate through required and elective learning opportunities in general medicine and internal medicine subspecialties based on their interests and career goals. Our department alone offers a range of twenty fourth-year courses in both inpatient and outpatient settings, including neighbor islands. As a whole, our medical education program enables learners to achieve JABSOM's graduation objectives and helps assure accreditation of the school by the Liaison Committee on Medical Education while educating current and future healthcare professionals and leaders.

This academic year we welcomed a new undergraduate medical education team with Dr. Florence Kan's appointment as Clerkship Director, and Drs. Miki Kiyokawa and Steven Azuma as Associate Clerkship Directors. Other highlights for this year include the acquisition of portable ultrasound machines ("Butterflies") which allowed us to incorporate point of care ultrasound (POCUS) training to our Third-Year Clerkship curriculum. Additionally, we created a Rural Medicine elective course in an effort to expand our education programs in neighbor islands.

UME LEADERSHIP

STEVEN AZUMA MD

ASSOCIATE PROFESSOR ASSOCIATE CLERKSHIP DIRECTOR

FLORENCE

KAN, MD

ASSISTANT PROFESSOR CLERKSHIP DIRECTOR

MIKI KIYOKAWA, MD

ASSOCIATE PROFESSOR ASSOCIATE CLERKSHIP DIRECTOR

UNIVERSITY OF HAWAII

INTERNAL MEDICINE RESIDENCY PROGRAM (UHIMRP)

UH Internal Medicine Residency Program White Coat 2024. Photo taken on June 27, 2023, Vina Cristobal.

AND LEAHI FUND ENDOWED CHAIR IN RESPIRATORY HEALTH

OUR MISSION

A MESSAGE FROM THE PROGRAM DIRECTOR

view UHIMRP as an extended family that emphasizes teamwork between our faculty, residents, students, and program staff. We aim to provide exceptional patient care, and to cultivate an optimal learning environment that is characterized by collegiality, shared responsibility, and professionalism.

Hawaii is a special place with rich diversity, and the spirit of Aloha should guide our interactions with patients and colleagues.

Mahalo, Dr. Reid Ikeda UHIMRP Program Director

Our MISSION is that residents, faculty and staff of UHIMRP will be dedicated to the service of our community in Hawai‘i and the Pacific through education, research and quality patient care.

OUR VISION

Our VISION is to become an ‘ohana (family) characterized by teamwork and mutual respect in a supportive learning environment. We envision a future in which we are integrated with the community, responsive and adaptive to change, and internationally renowned for excellence in patient care and the quality of our residents, faculty and medical education.

OUR RESIDENTS

LEVEL 1

LEVEL 2

YusukeHirao,MD

ToruNakata,MD

AbulhassanAli,MD

JoshuaHu,DO

ChristianCapirig,MD

JadonNeuendorf,MD

Chalothorn Wannaphut,MD

TedJacoby,MD*

SlatonCase,MD**

Sorawit Ongsupankul,MD

SydneyYee,MD*

CharlottePark,DO

SharinaMacapagal,MD

Thanaboon Yinadsawaphan,MD

AlyssaFinger,MD

KazushigeShiraishi,MD

BradleyFujiuchi,MD

ClarkeMorihara,MD

JonathanEstaris,MD

Noppawit Aiumtrakul,MD

Manasawee Tanariyakul,MD

OsamaHasan,MD

KevinEdward Nebrejas,MD

KyleAlimurung,MD

DillonTacdol,MD

ShuheiHattori,MD

Chinnawat Arayangkool,MD

KristineVo,MD

KelseyKwong,MD

KensukeTakaoka,MD

WeimingDu,MD**

ReedMcCardell Malone,MD

ToshiakiTakahashi,MD

StevenNamiki,MD

MaluikeauTang,MD**

NicoleChong,MD**

MikiYokokawa,MD 9/18/23-9/17/24

TitusDavid,MD

ArvinJeremyTan,MD

Aiko Murakami,MD

9/29/23-9/28/24

LEVEL 3

09/28/22-09/27/23

1/29/23-1/28/24

CHIEF MEDICAL RESIDENTS

JosephGo,MD

ToddNagamine,DO

YoshitoNishimura,MD

R.Haris Rizwan,MD

MohammadKhan,MD

KevinBenavente,DO

HarukiSawada,MD

LandonKozai,MD

BolinChang,MD

JasonKuniyoshi,MD

JoshuaTaylor,MD** Chesta,MD

JosephLee,MD

KyleDeacon,MD

WitinaTechasatian,MD

Thiratest Leesutipornchai,MD

BrendanTran,DO**

BryanAaron Ganzon,MD

ChengchengLi,MD

ChaseWarashina,MD

MaanGozun,MD

TarynMiyake,MD

GavinHa,MD

AmandaWasko,MD

AndrewPham,MD

UH Internal Medicine Residency Program Graduation. Taken on June 4, 2024.

AWARDS

PGY1 of the Year Award

ReedMcCardellMalone,MD,PhD

ClarkeMorihara,MD

Resident of the Year Award

KevinBenavente,DO

Ryder Onopa Most Inspirational

Resident of the Year Award

KevinBenavente,DO

Excellence in Medical Student Teaching Award

AbulhassanAli,MD

Excellence in Ultrasound Simulation Training Award

ArvinTan,MD

MaluikeauTang,MD

Excellence in Research

First Year:

ThanaboonYinadsawaphan,MD

Second Year:

NoppawitAiumtrakul,MD

KensukeTakaoka,MD

Third Year:

LandonKozai,MD

KevinBenavente,DO

FNUChesta,MD

WitinaTechasatian,MD

Outstanding PGY 1 at QMC Award

SydneyYee,MD

Outstanding Resident QMC Award

TarynMiyake,MD

Excellence in Ambulatory Medicine Award

ArvinTan,MD

KevinBenavente,DO

ToruNakata,MD

Outstanding Team Players

First Year:

ToshiakiTakahashi,MD

Second Year:

ShuheiHattori,MD

Third Year:

ChaseWarashina,MD

UNIVERSITY OF HAWAII

PRIMARY CARE INTERNAL MEDICINE RESIDENCY PROGRAM (UHPC)

OUR MISSION

The University of Hawai‘i Primary Care Internal Medicine Residency Program’s (UHPC) mission is to train culturally humble physicians equipped to provide high quality and equitable Primary Care to a diverse patient population. Graduates from the program will be prepared with the knowledge, skill set, and experience to provide Primary Care in various models of practice to improve the well-being of the people of Hawai’i.

OUR HISTORY

In 2018, JABSOM’s Internal Medicine Residency Program (UHIMRP) created small Primary Care Pathway/ Track, as of its existing Internal Medicine Residency Program. This “Track” was immensely successful, boasting an 85% retention of Primary Care physicians in Hawaii. Recognizing recently passed Federal legislation of the Consolidated Appropriations Act of 2021 and the rural designation of many Oahu hospitals, leadership from Queens Health System JABSOM’s Department of Medicine undertook initiatives to promote a NEW Primary Care Residency Program; which leveraged the new availability of sustained federal funds, to help create solutions to further mitigate critical Primary Care physician shortages in Hawaii.

JAMES YESS, MD PROGRAM DIRECTOR

UHPC STRUCTURE

AARON HOO, MD CORE FACULTY

BRYAN BROWN, MD ASSOC. PROGRAM DIRECTOR/ CORE FACULTY

UHPC is a completely new and distinct Internal Medicine training program, recently accredited September of 2023. Currently, UHPC is recruiting and interviewing applicants for its inaugural class, starting in July 2024. At its core, UHPC is structured to have a total complement of 12 residents spanning the three years of training, with 4 residents in each post graduate year.

Internal Medicine residencies have traditionally been focused on inpatient training, placing a heavy emphasis and the majority of rotations within the hospital setting. As opposed to traditional models of Internal Medicine residency programs, UHPC approximates about 1/3 of the training will be inpatient focused, allowing for the overwhelming majority of training time to be situated in outpatient ambulatory settings. This increased time availability will enable residents to focus on more primary care focused subspecialties, additional ambulatory experiences, and more rural health exposure. In addition, it will have the space to embrace a robust Native Hawaiian curriculum, which will help to further inform these new physicians with culturally- tailored and appropriate care.

BRANDON TAKASE, MD CORE FACULTY

UHPC STRUCTURE CONT.

The UHPC curriculum emphasizes a multi-specialty ambulatory training experience, focused on diverse exposures to consultative and ambulatory specialties that develop a well-prepared General Internist. Residents will be mandated to participate in 2-week ambulatory specialty experiences, such as Cardiology, Nephrology, Dermatology, Endocrinology, Pulmonology, Rheumatology & Musculoskeletal, Addiction Medicine, Geriatrics, Neurology and more. These rotations guarantee residents the opportunity to gain significant exposure and confidence in managing the most common outpatient problems. Of note, there will also be mandated 11 blocks of inpatient rotations (which UHPC residents will share with the categorical UHIMRP program).

A strong continuity clinic experience is at the core of the UHPC curriculum, and ample time is allotted to caring for the residents’ own primary care panel. The cornerstone of UHPC’s ambulatory training are the ambulatory immersion blocks. These strategically designed 4-week blocks occur twice each training year and include not only continuity clinics but also a combination of didactics, excursions, and/or clinical specialty experiences. Residents also return for continuity clinic half-days during rotations such as electives and specialty selectives to ensure effective continuity of care between the residents and their personal panel of patients.

In addition, we aim to strengthen our rural and neighbor island electives to allow our residents to gain experience with training in these underserved areas, and to increase success in placing new Primary Care physicians in those communities. Each UHPC resident will spend one month in the second year and one month in their third year of training at one of the various Primary Care sites off of Oahu, such as our collaborating sites on the islands of Maui, Hawai’i (“big island”), and Moloka’i. These rotations provide residents with firsthand experience of local community health initiatives across the islands, and significant time to learn from the outstanding physicians who proudly serve these regions of greatest need in our state. These opportunities allow residents to not only explore rural health across the state of Hawaii, but encourage the residents to be embedded culturally into the social fibers of the communities.

It is expected that the addition of this Primary Care Internal Medicine Residency will not only attract more qualified Primary Care interested learners to remain in Hawaii, but would hopefully provide a sustainable reliable pipeline aimed at replenishing and reinforcing the Primary Care workforce in our state.

KUROHARA, MD ASSISTANT PROFESSOR

Continued to play a key role in expanding our medical education programs as GME Neighbor-Island Coordinator for Maui island.

FACULTY SPOTLIGHTS

TARA REED, MD

ASSISTANT PROFESSOR

Joined our leadership as the GME Neighbor-Island Coordinator for Hawai'i island.

DANE

CARDIOVASCULAR DISEASE (CVD) FELLOWSHIP

OVERVIEW

In FY 23-24, we announced changes in our program leadership, enhancing our diversity and increasing scholarly and mentorship opportunities for our fellows. Dr. Omar Abdul Ghani, former Associate Program Director, assumed the role of Program Director on 12/1/23 when the former PD transitioned clinical practice away from our training sites. Dr. Helaine Kwong continues as Associate PD. Dr. Kwong also serves as a Patient Safety Officer for our health system and the Quality and Patient Safety Academic Program Lead for our department. Dr. Alan Kuo was appointed as our second Associate Program Director. All of the PD and APD appointments were reviewed and approved by our Graduate Medical Education Committee. They are active members of our Program Evaluation Committee (PEC) and are dedicated to program improvement.

We expanded our didactic curriculum starting in July 2023, featuring multiple weekly lectures on general cardiology topics. This has significantly improved our survey results regarding the balance between education and patient care, as well as the protected time to participate in structured learning activities.

Through a collaboration with the Sponsoring Institution’s Center for Learning Innovation, we launched the Recognizing, Inspiring, and Developing Great Educators program (RIDGEtrail) for our Faculty. RIDGEtrail promulgates evidencebased methods for curriculum development, assessment, and feedback, and includes both didactics and coaching by expert educators during actual educational sessions with our faculty and fellows. This initiative has contributed to the improvement in our survey results regarding faculty interest and amount of teaching. We plan to focus on questioning skills (environment of inquiry) and assessment for progressive autonomy in the coming year.

Starting in the next academic year (July 2024), all our fellows will take the American College of Cardiology (ACC) intraining examination. This change, from previously only including first-year and third-year fellows, will help both fellows and faculty assess the knowledge gained during the first year of training.

To enhance our fellows' exposure to rural cardiology practice, we are now offering an elective rotation at North Hawaii Community Hospital. This hospital, located on the neighboring Big Island, serves the rural community in the northern part of the island. During this rotation, fellows will gain experience in both inpatient and outpatient cardiology.

PROJECT CARE

Project CARE (CPR and Rescue Empowerment), previous Project HEART, is a student-run organization at JABSOM that aims to connect with local public high school students who are pursuing a healthcare career and enrich their education by providing mentorship, promoting healthy lifestyles, and teaching them skills that will translate to their future profession.

OUR CVD FELLOWS

Rahul Ahuja, DO

Huzefa Bhopalwala, MD

Monika Bernas, MD

Kevin Lee, MD

Pooja Dhruva, MD

Andrew Lee, MD

Uzoagu Okonkwo, MD

Gagandeep Rajpal, MD

Kimberly Vu, MD

Benita Tjoe, MD

Parthav Shah, MD

ACCOMPLISHMENTS

visit to Roosevelt High School, teaching students about CPR and different careers in the healthcare field

visits to Farrington High School, teaching students about first aid, CPR, heart and lung physician exam, and different careers in the healthcare field

Updated the case-based curriculum to incorporate other healthcare roles such as EMTs, nurses, dietitians, and physical therapists

Created a pamphlet with information about the education and training requirements for several healthcare careers, with emphasis on programs in Hawaii

Developed a new partnership with AMR to teach CPR at health fairs in the community; received resources including CPR kits

Expanded our student team and created new leadership roles to direct our endeavors in connecting with more high schools, developing curriculum, and building relationships with community organizations

IN PROGRESS/FUTURE DIRECTIONS

Finalize plans for visits to Kalani, Pearl City, and McKinley High School

Develop a curriculum for Farrington’s simulation facility

Obtain CPR instructor certifications for some of our members and assist with CPR certification for Farrington High School’s seniors

AMR coverage at elementary school fitness day (3rd and 4th graders) at these respective high schools: 2/8 Mililani, 2/15 Wailua, 2/23 Radford, 2/29 Moanalua, 3/1 Leilehua, 3/7 Aiea

Host a CPR demonstration at Sacred Hearts Academy’s Science Symposium 4 Girls on 3/2

Expand to neighbor islands Feb 20th in Lanai

Reach out to UCLA Project CARE to share what we’ve been doing and see if we can have them align with our goals –thereby creating a multi-state coalition in addressing CPR preparedness

COMMUNIT ENGAGEME

PAPAKOLEA ʻOHANA HEALTH FAIR

Our department understands the crucial role of community engagement in fostering health and wellness in Hawaii. Through collaborations with local organizations and healthcare providers, we actively participate in health promotion initiatives, screenings, and educational seminars focused on raising awareness about preventive health and disease management. Each year, our involvement in the Papakolea Ohana Health Fair brings together faculty, students, residents, and community members, creating an opportunity for everyone to share cultural insights and health practices.

AMERICAN COLLEGE OF PHYSICIANS (ACP) HAWAI’I CHAPTER

2024 HAWAII CHAPTER ANNUAL SCIENTIFIC MEETING

ABSTRACT COMPETITION WINNERS

RESIDENT RESEARCH

First Place: Clarke Morihara, MD

"Ockham's Razon and Bayes Theorem at work, a Case Series: Analyzing the sensitivity and specificities of Brugada, aVR Verecki, and Basel algorithms in evaluation of Wide Complex Regular Tachycardias amongst a Multiracial population. "

STUDENT RESEARCH

First Place: Ayumi Sakamoto

"Mobility Device Use and Frailty Progression in Older Adults with Mobility Impairment"

Second Place: Sarah Bellati

"Findings from the First Systematic Survey of Surfer's Myelopathy Patients"

Third Place: Luke Taylor

"Risk Factors Associated with One-Year Mortality

After Osteoporotic Hip Fracture in Hawaii: Higher Mortality Risk Among Native Hawaiians and Other Pacific Islanders"

TOP FELLOW RESEARCH PRESENTATION

Kathryn Choo Loy, MD

"Deprescribing of Potentially Inappropriate Medications (PIMs) Across Four Geriatric Care Settings"

TOP RESIDENT CASE PRESENTATION

Weiming Du, MD

"A case of Reversible Cerebral Vasoconstriction Syndrome (RCVS) on an eclamptic patient"

TOP MEDICAL STUDENT CASE PRESENTATION

Keith Nakamatsu

"Unmasking Graves’ Disease: A Paralysis Case in the Emergency Department"

Medical Student Jonathan Hu (right) presenting to ACP Judges Dr. Kuo Lian (left) and Dr. Sam Evans (center).

ELIZABETH "LIZ" KEALI'IKUA'AINA TAM, MD MEMORIAL AWARD

2024 Awardee - Dominic Chow, MD, PhD, MPH

Award Presented Wednesday, May 8th, 2024

Awarded to a JABSOM Department of Medicine faculty member who emulates the passion, grace, leadership, and dedication of Dr. Elizabeth “Liz” Keali‘ikua’āina Tam, who fostered lifelong learning in clinical care, research, and teaching while advocating for cultural humility and equity in medicine in addition to advancing lung health in Hawaii.

Pictured Left to Right: Scott Kuwada, MD, AGAF, FACP (Department Chair), Kaeo Tam (Dr. Tam's Brother), Dominic Chow, MD, PhD, MPH (Awardee), Dee-Ann Carpenter, MD (Elizabeth Tam Committee Chair)

RESEARCH ENDEAVORS

The Department of Medicine at the University of Hawaii has made remarkable progress in advancing medical knowledge, enhancing patient care, and supporting innovative research throughout the 2023-2024 academic year. With a dedicated team of researchers, clinicians, and staff, we have achieved significant milestones in medical research, education, and community outreach. Our commitment to excellence in healthcare and scientific discovery remains steadfast as we navigate the challenges and opportunities within the rapidly evolving field of medicine.

A key priority for our department continues to be reducing health disparities among Hawaii’s diverse populations. Through community-based participatory research and initiatives focused on health equity, we are actively working to improve healthcare access and outcomes for underserved communities.

RESEARCH INFRASTRUCTURE

Faculty members in the Department of Medicine are deeply involved in two major NIH-funded research infrastructure and training grants: the Center for Pacific Innovations, Knowledge, and Opportunities (PIKO) and Ola HAWAII. These grants provide essential funding and mentorship to early-career investigators, supporting their development as future leaders in research. Through funding from the Institutional Development Award Networks of Clinical and Translational Research (IDeA-CTR), the Center for PIKO has been established to foster the development and to facilitate the implementation of innovative and evidence-based clinical and translational (CTR) projects aimed at improving the health of Indigenous Pacific People (IPP, defined as Native Hawaiians, Pacific Islanders and Filipinos) and other underserved populations in Hawaii. The PIKO collaborative, which represents a partnership between the University of Hawaii (UH), Hawaii Pacific University (HPU), Chaminade University of Honolulu (CUH), and a large statewide network of 18 practicebased organizations (PBO) and other community-based organizations (CBO), will develop new and leverage existing resources to ensure real-world impact.

Achieving health and wellness for the communities in Hawaii, which suffer disproportionately from genetic, environmental and socio-economic disparities in health and healthcare access, is the rationale for the Research Centers in Minority Institutions (RCMI) Specialized Center. The strategic goal of the RCMI Center in Hawaii, named Ola HAWAII, is to grow and support a community of health disparities investigators and collaborators (the “workforce”) to harness the power of diverse thought (the “thinkforce”) to determine the causes of and interventions for health disparities in the Pacific.

EDUCATION AND TRAINING

In addition to our research efforts, the Department of Medicine is dedicated to training the next generation of healthcare professionals and researchers. Our educational programs, which include residency training, fellowships, and continuing medical education initiatives, offer comprehensive instruction in clinical care, research methods, and evidence-based practice.

HEALTH SYSTEMS COLLABORATION

Collaborating with our two largest local health systems, Hawaii Pacific Health and Queen’s Medical Systems, has been a key priority for our department. Through our research infrastructure grants, we have been exploring innovative ways to leverage medical records using TriNetX. TriNetX is a global platform that connects healthcare organizations, researchers, and life sciences companies to enhance clinical research and improve patient outcomes. It offers a real-time, cloud-based data analytics platform that enables users to query and analyze clinical data from electronic health records (EHRs), providing valuable insights into patient populations, disease patterns, and treatment outcomes. This past year, our faculty have utilized TriNetX to investigate health issues that are crucial to our communities.

The year has been marked by significant our successes and challenges, we reaffirm health and well-being. We extend our heartfelt for their unwavering support, dedication, making meaningful strides in expanding Hawaii and beyond.

Looking forward, the Department of Medicine and community engagement. We remain population, fostering cross-disciplinary in patient care and public health outcomes.

The Department of Medicine comprises three primary research units: (1) the Center for Cardiovascular Research, (2) the Hawai‘i Center for AIDS Research, and (3) the Magnetic Resonance Imaging Center. Accomplishments from each of these units over the past year are highlighted in the following sections.

THE CENTER FOR CARDIOVASCULAR RESEARCH

Our cardiology research leaders met at the 7th annual International Hawaii Cardiovascular Symposium in February 2024. The IHCVS is organized by Dr. Matsui of the CCR and Lorrie Kirshenbaum of the University of Manitoba.

OUR PURPOSE

The purpose of the Center for Cardiovascular Research (the CCR) is to train the next generation of cardiovascular investigators and produce a better understanding of cardiac disease. The CCR is a community of scientists that includes the labs of 5 principal investigators on the third floor of the BioScience Building at JABSOM: Drs. William Boisvert, Takashi Matsui, Ralph Shohet, Michelle Tallquist, and Ken Zhang. Several other faculty collaborate with these investigators and utilize resources of the Center including Drs. Olivier LeSaux, Noemi Polgar, Kathryn Shunke, Ben Fogelgren, and Mariana Gerschenson. Each laboratory has distinct areas of focus, Dr. Boisvert the immunology of atherosclerosis, Dr. Matsui signaling and programmed cell death, Dr. Shohet hypoxia and gene delivery, Dr. Tallquist the cardiac fibroblast, and Dr. Zhang the use of induced pluripotent cardiomyocytes to understand cardiac pathology. During fiscal year 2024 important accomplishments included 1. Continued or new grant funding, 2. Publications, and 3. Career progress of our trainees. We also provide echocardiography services to investigators doing cardiovascular research.

GRANTS

Highlights include our T32 training grant, the first at the University, which has enabled us, over the past 10 years, to support three graduate students and three postdoctoral fellows every year. We have obtained a third cycle of funding which began in August of 2024. This cycle will be led by Dr. Tallquist with Dr. Shohet serving as deputy director. This grant has also helped to inspire two subsequent successful T32 applications, one a collaboration between the Cancer Center and USC, and the other a collaboration between the School of Nutrition and the Bioinformatics Dept at JABSOM. Dr. Shohet has played an advisory role for both of these. Other important grants have included continued success in funding the independence of our young investigators with two K99-R00 awards, the first to Andrew Knutson, a Native Hawaiian investigator in Dr. Shohet’s lab and a second to John Yap, a Native Hawaiian investigator with Dr. Boisvert, who has the additional distinction of having completed his undergraduate and graduate education as a quadriplegic trainee. Dr. Matsui obtained HCF funding for his studies of how cell death can propagate down cardiac fibers in infarction. Dr. Zhang obtained funding from Ola Hawaii for an AI project in congenital heart disease and a pilot project to study biomarkers in Native Hawaiian cardiac patients. He plays a key role in the Bioinformatics T32 and has recently obtained an unusual NIH UE5 training grant in computational genomics for undergraduates. We have also had extraordinary success in obtaining predoctoral and postdoctoral awards for our young investigators.

Research in the Boisvert Lab are focused on exploring immunity and inflammation in the pathogenesis of atherosclerosis.

PUBLICATIONS

Dr. Tallquist’s group continued to work on cardiac fibrosis. This work resulted in 7 publications. Dr. Shohet had a publication on using a novel form of gene delivery to deliver Crispr constructs to the liver of mice, and a paper on how pyruvate kinase helps to regulate cardiac metabolism. Dr. Boisvert continued a productive collaboration with the AIDS group on atherosclerotic burden in patients with AIDS, and also had publications on Covid in the testes, and hair regeneration! Dr. Matsui has continued to work on ferroptosis, describing how it spreads among heart cells. And Ken Zhang published his work on epigenomics of heart cell development.

TRAINING

Drs.ShohetandTallquistintroducingcardiovascularresearchtrainees.

Two of Dr. Tallquist’s postdocs left in the past year, one for further training at UCSD and one to begin an assistant professorship at Osaka University. Dr. Shohet’s graduate student Katie Lee obtained an AHA predoc award for her thesis work on cardiac metabolism, and graduated this October, and his postdoc April Darrow received both an AHA postdoc award and an Ola Hawaii pilot award for her work on methamphetamine cardiomyopathy. All faculty participate in training of medical students with Drs. Tallquist, Matsui, and Shohet leading PBL groups. Dr. Matsui also organizes the annual International Hawaii Cardiovascular Symposium, that bring investigators from around the world to discuss recent basic advances in heart disease. Dr. Shohet also plays a role in our Cardiology Fellowship, based at Queens Medical Center, where he helps to admit, train, and evaluate clinical fellows.

ADMINISTRATIVE CONTRIBUTIONS

The faculty of the CCR provides a substantial amount of administrative leadership at the School. Dr. Tallquist in particular has served as Cell and Molecular Biology graduate chair, Institutional Biosafety Committee rep, Graduate Council rep, Undergraduate Research Opportunities Council rep, JABSOM Faculty Senate-vice chair, JABSOM curriculum committee, and Senate Executive Committee-vice chair. Dr. Matsui serves as Chair of Anatomy, Physiology, and Biochemistry. Dr. Boisvert serves on the Student Standing and Promotion Committee and has recently become interim Chair of Tropical Medicine. Dr. Shohet, who is the Director of the CCR, served on several tenure and promotion committees and served on the Dean Search Advisory Committee that selected our new Dean.

HAWAI’I CENTER FOR AIDS RESEARCH

RCMI Consortium National Conference 2024.

Cecilia Shikuma, MD taken by Reese Murayama.

The Hawaii Center for AIDS (HICFA), directed by Dr. C Shikuma, is a University of Hawaii Board of Regents’ approved Center of Excellence for HIV research, training and care. HICFA maintains an office, a processing laboratory, and a research clinic at the UH Clinics at Kakaako located directly on the JABSOM campus. Its fee-forservice HIV Clinic previously co-located at the UH Clinics at Kakaako moved this year into the Queen Emma Clinic (QEC). It is still directed by D. D Chow.. HICFA is involved in the training of graduate students as well as medical students and residents. In research, laboratory research is conducted by 5 Dept of Tropical Medicine faculty (J Park, I MacPherson, M Agsalda, A Garcia, and M Honda) affiliated with HICFA and clinical research activities by 3 Dept of Medicine faculty (C Shikuma, D Chow andC Akamine). Dr. C Akamine, Assistant Professor of Medicine, is an Infectious Disease specialist and our newest addition to the HICFA faculty.

HICFA maintains an infrastructure for HIV clinical trials (research physicians, clinical research coordinators, processing lab, research pharmacist, research clinic space) and has a long history of providing patients living with HIV in Hawaii access to the latest HIV/AIDS antiretroviral therapy trials. Currently HICFA participates in Gilead’s phase 2 trial assessing the combination of oral weekly Islatravir in combination with Lenacapavir (GS-US-563-6041) to control HIV viremia. Over the past decade, as the health of this population has improved, HICFA’s primary HIV research focus has turned to the chronic age-related omplications of HIV and the role of HIV immune activation is this process. We have published extensively on how monocyte/macrophage immune activation instigated by HIV contributes to the asdfasd

higher risk of cardiometabolic impairment in this population. HICFA now intends to address the final frontier of HIV research –that of HIV cure, and is planning a small collaborative early phase clinical trial involving 2 medications, auranofin and buthionine sulfoximine (BSO), intended to leverage the body’s antioxidant pathways to reduce the HIV latent reservoir.

HICFA conducts its research and care activities in close collaboration with the community and programs involved in assisting individuals with or at risk for HIV. This includes the State of Hawaii Department of Health Harm Reduction Branch and the state’s Ryan White and STD programs, community physicians and other health clinics involved in HIV care, and various AIDS Service Organizations (ASO) on Oahu and the neighbor islands.

In 2020 with the beginning of the COVID-19 pandemic, HICFA pivoted to take on research on SARS CoV2. Currently, some COVID related research projects HICFA is involved in include the national NIH-funded multi-center RECOVER cohort study (https://recovercovid.org/) designed to study the pathobiology of Long COVID; the 5 year Ola HAWAII project ‘Factors Responsible for the Development of Pulmonary Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) in Hawaii’ (Project MPI G Devendra, Assistant Professor Dept Medicine and J Park, Assistant Professor Dept of Tropical Medicine); the Leahi Foundation grant ‘Role of Anti-idiotype Autoantibodies (AA) directed against ACE2 in the Development of Pulmonary Post-Acute Sequelae of SARS-CoV2 Infection’ (PI C Shikuma); and the Angus Foundation grant ‘COVID-19 Infection in Hawaii’ (PI T Seto/C Shikuma). In clinical trials work, HICFA is conducting NIH’s RECOVER-AUTONOMIC Clinical Trial, focused on autonomic dysfunction symptoms related to Long COVID, such as fast heart rate, dizziness, and fatigue. These symptoms are related to damage to nerves that are part of the autonomic nervous system, which controls automatic body functions like heartbeat and blood pressure. In conducting this trial, HICFA is working closely with the QEC’s Post-COVID Clinic directed by Dr. Chow.

2023-2024 | RESEARCH | HICFA

HICFA’s clinical research/trials infrastructure serve as the Clinical Research Resource Cores for 2 research infrastructure grants at the medical school: Ola HAWAII (https://ola.jabsom.hawaii.edu/) and PIKO (https://piko.jabsom.hawaii.edu/). This Core provides clinical research consultation for researchers interested in clinical research projects. Dr. D Chow serves as the Program Director of Ola HAWAII and Dr. C Shikums directed the Clinical Services Core of both of these research infrastructure grants.

HICFA is involved in 2 other initiatives important to promoting research in Hawaii. The Hawaii Clinical Research Network for Health Equity (NIMHD UG3MD08358; MPI C Shikuma, T Seto and V Balaraman) will merge the electronic health records (EHR) of the Queen’s Health System and Hawaii Pacific Health to create the beginnings of a de-identified Hawaii-wide Data Network that can be queried for research questions important to Hawaii and its population. This initial Data Network is anticipated to contain data on approximately 70% of Hawaii’s population. The EHR from both medical systems are now ready to be merged, and current efforts are focused on a data use agreement (DUA) on how this database will be utilized. This grant also funds 2 studies focused on early detection of fatty liver disease utilizing portable FibroScans in our community’s health disparity population (Project PI C Tran, Hepatologist and Assistant Professor Medicine; Mentor S Kuwada) and in our HIV population (Project PIT Sempokuya, Hepatologist and Assistant Professor Medicine, Mentor D Chow). These projects will soon be initiated at 2 local community clinics - Kalihi Palama and Waikiki Health. In an exciting addition, an administrative supplement has now been awarded to this grant to expand the study to 3 neighbor island clinics – to North Kohala, Kauai, and to Molokai.

HICFA is participating in the IDeA State Consortium for Clinical Research Resource Center (ISCORE-RC; NIGMS U24GM150446, PI S Hodder [West Virginia], Hawaii Site PI: C Shikuma). This grant intends to increase clinical trials in IDeA States (of which Hawaii is one) through communication of opportunities, effective marketing, and workforce development. ISCORE-RC has started to notify its sites of various multi-center clinical trial opportunities. ISCORE-RC also manages a Clinical Research Coordinator training program which combines an extensive didactic on-line training program with a preceptor supervised hands-on clinical research experience locally in Hawaii. A certificate is awarded following a final evaluation process. Currently 5 trainees and 2 preceptors are enrolled from Hawaii in this program.

UNIVERSITY OF HAWAII

MAGNETIC RESONANCE RESEARCH CENTER

and Zidan

The University of Hawaii Magnetic Resonance Research Center (UHMRRC) is located in the Department of Medicine at the John A. Burns School of Medicine (JABSOM). The UHMRRC has access to a 3 Tesla MRI scanner located at Queens Medical Center that has capabilities to perform whole body scans for both clinical and research purposes. The Center is staffed by two Medicine faculty V. Andrew Stenger, PhD and Christoph Rettenmeier, PhD and two staff members Zidan Yu, PhD and Steven Buchthal, PhD working. All four members have extensive experience with the use of MRI for research and clinical applications. The faculty and staff are located on the th floor of the UH Medical Tower at the QMC campus. In addition to our permanent staff, there are several JABSOM medical students and UH Manoa students involved in our ongoing research activities.

extramural support with several ongoing research currently five NIH funded projects, one DOD funded project, and one Hawaii Community Foundation project being run in the Center involving collaborations between JABSOM, PBRC, and the UHCC. These projects range from MRI methods development to the study of disease. A large focus is on the use of MRI to image brain function (fMRI) non-invasively in vivo (Stenger, Andres) for investigating drug addiction. There are also three studies (Rettenmeier, Le Marchand, Lim) for imaging liver fat and fibrosis to probe a range of diseases including NASH and links to cancer and dietary interventions. Finally, there is a pilot study from the Hawaii Community Foundation (Matsui, JABSOM Department of Anatomy) to use diffusion MRI to probe heart disease. Besides the extramurally funded studies, three pilot projects including collaborations with the UHCC, Dept. of Psychology and Linguistics are currently underway. In particular the Dept. of Psychology has recently recruited a new faculty Casandra Hendrix who will be conducting fetal and neonatal MRI at the Center.

Drs. Zidan Yu (left), Christoph Rettenmeier (center), and V. Andrew Stenger (right).

In addition to its research activities, the UHMRRC has played a key role in updating the Gross Anatomy curriculum at JABSOM in recent years by providing high-quality whole-body imaging material for the case-based dissection labs. Under the leadership of Dr. Lozanoff, the Department of Anatomy has worked to digitalize and enhance the learning experience for medical students, ensuring effective anatomy training during the pandemic and continuing to engage students today.

Drs.

Yu (left), Christoph Rettenmeier (center), and V. Andrew Stenger (right).

V. ANDREW STENGER, PhD PROFESSOR

Continued his research "Radial Echo Volumar Imaging Grant" (PI), "Integrative Center for Precision Nutrition and Human Health", and "Effects of Intermittent Energy Restriction on Intra-Abdominal Fat and the Gut Microbiome: A Randomized Trial". Was part of the teams to present at conferences such as the Proceedings of the ISMRM & ISMRT Annual Meeting & Exhibition and the International Conference on Systems Engineering.

IER,PhD

HER

Continued his research on the development of medical imaging technologies at the MRI Research Center with a focus on quantitative imaging of the liver in the context of liver disease and metabolic health as well as functional brain imaging. As a Research Project Leader of the COBRE initiative on “Precision Nutrition” he has been studying the use of a portable low-cost imaging device based on electrical impedance measurements to assess liver steatosis. This promising technology could facilitate broad screening of MASLD and help tackle one of the major health issues here in Hawaii. Among several other extramurally funded studies, he is involved in the ongoing population-based research collaborations with investigators at the University of Hawaii Cancer such as the "Longitudinal Study of Early NAFLD Progression and the Gut Microbiome in Asian Americans, Native Hawaiians and Whites" and the “Effects of Intermittent Energy Restriction on Intra-Abdominal Fat and the Gut Microbiome: A Randomized Trial” which included over 270 liver MRI examination at the MRI Research Center within the past fiscal year. His work was presented at the 2024 JABSOM Biomedical Symposium and the international conference ISMRM & ISMRT Annual Meeting & Exhibition.

PHILANTHROP

We are deeply grateful for the support received over the past year via the University of Hawai’i Foundation. Private, often anonymous donations have helped us to fulfill our departmental mission in multiple ways, including:

Endowed Chair

New Fellowship Program

Faculty development

Research endeavors

Neighbor island outreach

Resident and medical student academic development

Staff professional development

Clinical Faculty recognition

Visiting professorships

JOHN C. COUCH FUND FOR HEPATOLOGY AND THE JOHN C. COUCH

ENDOWED CHAIR IN HEPATOLOGY

The Department of Medicine is beyond grateful for an incredibly generous $3.76 million gift from Mr. John C. Couch, a former Hawaii resident and liver cancer survivor. This gift paves the way for JABSOM’s Department of Medicine to develop Hawaii’s first Gastroenterology Fellowship program, training future specialists in gastroenterology/hepatology here in Hawaii for Hawaii. This transformative donation will build partnerships with local health systems and allow Hawaii’s liver transplant patients to embrace their care in Hawaii instead of seeking specialized pre and post-care on the continental US. Mr. Couch's remarkable journey and heartfelt contribution will undoubtedly inspire a new generation of medical professionals dedicated to excellence and innovation in patient care, serving the population of our local communities.

DR. KEN AND MRS. GEMIE ARAKAWA ENDOWED CHAIR IN MEDICINE CELEBRATION

On May 1, 2024, the UH Department of Medicine held a special ceremony to honor Dr. Ken Arakawa and Mrs. Gemie Arakawa for their extraordinary generosity. Their $2.08M donation played a pivotal role in establishing the department's first-ever Endowed Chair, providing salary support for the JABSOM/UH Chair of Medicine in perpetuity. The Arakawa’s gift will help attract and retain top faculty and residents, a key factor to addressing the current physician shortage affecting our island community.

Pictured Left to Right (Front): Scott Kuwada, MD, AGAF, FACP (Department Chair), Lee Buenconsejo-Lum, MD, FAAFP (Interim Dean), Ken C. Arakawa, MD and Gemie Arakawa (donors)

Pictured Left to Right (Back): Tim Dolan (UH Foundation), Thomas Kosasa, MD

CVD FELLOWS RESIDENTS MEDICAL STUDENTS

PUBLICATIONS

1. Abdul Ghani O, Tjoe B, Dhruva P, Kawamoto K. MicrobubbleFormationFollowingMechanicalSupportwithImpellaCPPlacementinPatientwith NarrowAorticRoot.Presentedat:ACC2024AnnualMeeting;2024Apr6;Atlanta(GA).

2 Acoba JD, HiranoT, Nakasone R, Rho YS PancreaticcanceramongPacificIslanders:acomprehensiveanalysisofanunderstudiedracialgroup Ethn Health.2023Jul;28(5):650-660.doi:10.1080/13557858.2022.2116631.Epub2022Aug28.PMID:36036201.

3. Aiumtrakul N,ThongprayoonC, Arayangkool C, Vo K, Wannaphut C,SuppadungsukS,KrisanapanP,GarciaValenciaOA,QureshiF,MiaoJ, CheungpasitpornW.PersonalizedMedicineinUrolithiasis:AIChatbot-AssistedDietaryManagementofOxalateforKidneyStonePrevention.JPersMed. 2024Jan18;14(1):107.doi:10.3390/jpm14010107.PMID:38248809;PMCID:PMC10817681.

4. Aiumtrakul N,ThongprayoonC,SuppadungsukS,KrisanapanP,MiaoJ,QureshiF,CheungpasitpornW.NavigatingtheLandscapeofPersonalized Medicine:TheRelevanceofChatGPT,BingChat,andBardAIinNephrologyLiteratureSearches.JPersMed.2023Sep30;13(10):1457.doi: 10.3390/jpm13101457.PMID:37888068;PMCID:PMC10608326.

5.AndersonCD,ArthurJA,ZhangY,BharuchaN,KarakikesI, Shohet RV.Non-viralinvivocytidinebaseeditinginhepatocytesusingfocusedultrasound targetedmicrobubbles.MolTherNucleicAcids.2023Aug1;33:733-737.doi:10.1016/j.omtn.2023.07.032.PMID:37662969;PMCID:PMC10468349.

6. Arayangkool C, Gozun M, Tanariyakul M, Techasatian W,LeesutipornchaiT, Nishimura Y.BileCastNephropathyBecauseofAcuteLiverInjury AssociatedWithSelectiveAndrogenReceptorModulators.ACGCaseRepJ.2023Jul26;10(7):e01105.doi:10.14309/crj.0000000000001105.PMID: 37501938;PMCID:PMC10371315.

7.AsgarJ,BenchakrounA,DewaswalaN, Bhopalwala H, RehanM,DuchowM,BaliS.DecisionsonAnticoagulation:UniqueDilemmaRegarding AnticoagulationinPatientonVeno-VenousECMO Chest 2023;164:A2654-A2655 doi:101016/jchest2023071760

8.AwamuraT, Nakasone ES, Gangcuangco LM,SubiaNT,BaliAJ, Chow DC, Shikuma CM,ParkJ.PlateletandHIVInteractionsandTheirContributionto Non-AIDSComorbidities.Biomolecules.2023Nov2;13(11):1608.doi:10.3390/biom13111608.PMID:38002289;PMCID:PMC10669125.

9.Bellatti,S;Choi,JW;Wilson,JN; Brown, SC.FindingsfromtheFirstSystematicSurveyofSurfer'sMyelopathyPatients.AmericanCollegeofPhysicians, HawaiiChapter.

10.BenaliF,SinghN,FladtJ,JaroenngarmsamerT,BalaF,OspelJM,BuckBH,DowlatshahiD,FieldTS,HanelRA,PeelingL,TymianskiM,HillMD, Goyal M, GaneshA;ESCAPE-NA1Investigators.MediationofAgeandThrombectomyOutcomebyNeuroimagingMarkersofFrailtyinPatientsWithStroke.JAMA NetwOpen.2024Jan2;7(1):e2349628.doi:10.1001/jamanetworkopen.2023.49628.PMID:38165676;PMCID:PMC10762575.

11. Benavente K, Kozai L, SilangcruzK, Banerjee D.Therisksofrejectionvs.infection:RamsayHuntsyndrome,Gradenigosyndrome,andvaricella meningoencephalitisinahearttransplantpatient EurHeartJCaseRep 2023Aug3;7(8):ytad373 doi:101093/ehjcr/ytad373 PMID:37575545;PMCID: PMC10413418.

12. Benavente K, Moreno JP, Banerjee D. WithdrawalOfAtrioventricularNodalBlockingAgentsinPatientsReceivingMavacamten:ARetrospectiveSingleCenterExperienceinAPredominantlyAsian-AmericanCohort.AmJCardiol.2024Apr1;216:63-65.doi:10.1016/j.amjcard.2023.11.027.Epub2023Nov25. PMID:38008348.

13. Berg, B.IMSH-SimulationSociety-POSTER:FamilyPresenceduringresuscitation(poster).

14.BhavaniSV,RobichauxC, Verhoef PA,ChurpekMM,CoopersmithCM.UsingTrajectoriesofBedsideVitalSignstoIdentifyCOVID-19Subphenotypes. Chest 2024Mar;165(3):529-539 doi:101016/jchest202309020 Epub2023Sep23 PMID:37748574;PMCID:PMC10925543

15. Brown B,DoolittleBR,GielissenKA.MedicalEducatorasGameMaster:WhatDungeons&DragonsCanTeachUsAboutSmallGroupLearning.JGradMed Educ.2023Aug;15(4):428-431.doi:10.4300/JGME-D-22-00943.1.PMID:37637326;PMCID:PMC10449354.

16. Brown B,KangG,SchwartzA,RinkA,GallantN,Magpantay-MonroeE,Empleo-FrazierO,WindishD,MarottoliR.CognitionanddementiawithRaymond andBrain:Curriculumdevelopmentandevaluationusinginteractiveanimatedflipped-classroommodulestoimpactnursingstudents'attitudetoward dementiacare.NurseEducPract.2023Aug;71:103696.doi:10.1016/j.nepr.2023.103696.Epub2023Jul1.PMID:37453370.

17. Brown, SC;Both,C;Dowsett,L;Fox,K; Nakagawa, K;Gerschenson,M;Falcone,GJ.GeneticPredispositiontoDiabetesandRiskofStrokeinNative Hawaiians.InternationalStrokeConference.

18 Bruno MK,MatsunagaM,KreningE, Gao F,ChenJJ, Seto T, Ross GW ThePrevalenceofHospitalizedParkinson'sDiseasePatientsinAllCase HospitalizationamongDifferentRace/EthnicSubgroupsinHawaii.JParkinsonsDis.2024;14(4):725-735.doi:10.3233/JPD-230341.PMID:38607763.

19. Bruno MK,MatsunagaM,KreningE, Nakagawa K,ChenJJ, Seto T, Gao F,TannerC, Ross GW.Racialdisparitiesinhospitalizationcharacteristicsamong NativeHawaiians,PacificIslandersandAsianAmericansubgroupswithParkinson'sdisease.ParkinsonismRelatDisord.2024Apr;121:106018.doi: 10.1016/j.parkreldis.2024.106018.Epub2024Feb2.PMID:38359475.

20 Bruno MK,MatsunagaM,KreningE, Nakagawa K,ChenJJ, Seto T, Gao F,TannerC, Ross GW. Racialdisparitiesinhospitalizationcharacteristicsamong NativeHawaiians,PacificIslandersandAsianAmericansubgroupswithParkinson'sdisease.ParkinsonismRelatDisord.2024Apr;121:106018.doi: 10.1016/j.parkreldis.2024.106018.Epub2024Feb2.PMID:38359475.

21.CaoK,ParekhM,DewaswalaN, Bhopalwala H,ArbuneA.Immunecheckpointinhibitor-inducedmyocarditis:atruedilemma.Chest.2023;164(4Suppl). doi:10.1016/j.chest.2023.07.246.

22.ChenR,MorrisBJ,DonlonTA, Ross GW,KallianpurKJ,AllsoppRC, Nakagawa K,WillcoxBJ,MasakiKH.IncidenceofAlzheimer'sDiseaseinMenwith Late-LifeHypertensionIsAmelioratedbyFOXO3LongevityGenotype.JAlzheimersDis.2023;95(1):79-91.doi:10.3233/JAD-230350.PMID:37483002; PMCID:PMC10578238.

23. Chesta F, Kan F, Abdul-Ghani A, Evans S.MalignantSolitaryFibrousTumorofthePleura:ADiagnosticandTherapeuticChallenge.PresentedatCHEST 2023.Chest.2023;164(4,Suppl):A3740.

24. Chesta F, Pham A, Evans S. BronchoscopicBattles:TheVanishingValve.PosterpresentationatCHEST2023.Chest.2023;164(4,Suppl):A5453.

25. Chesta F, Shah P, Evans S, Sato R,WuT,TangA.ADiagnosticOdyssey:IncidentalFindingofaPrimaryPulmonaryLeiomyosarcomainaPatientwith PulmonaryEmbolism.PosterpresentationatCHEST2023.Chest.2023;164(4,Suppl):A4115-A4116.

26 CheungAJ,NishimuraMK,MiyakiKJ,StephensTA,WeldonEJ,JahansoozJR,LeeAY, MatsunagaM,ChangJC,CarrazanaE,ViereckV, Liow KK Exploring Radiculopathyin UnderservedCommunities:AFocusonAANHPIPopulationsandRiskFactors.Neurology102 (17supplement1),5405American AcademyofNeurology2024AnnualMeeting,April15, 2024Denver,CO.

27.ChoiJ,JinK,WilsonJN, Pham A, MehtaTI,TsappidiS,ZhangJY,HuiFK, Brown SC.FighterPilotSyndrome:ABowHunterSyndromeVariantIdentified WithDynamicCerebralAngiography.Stroke:VascularandInterventionalNeurology.2024January.

28.ChoiJW,HoR,ZhangYJ,Sae-OwW,HuiFK, Brown SC,TsappidiS.Ararecaseofsolitary,isolatedduralmetastasisfromhepatocellularcarcinoma mimickingameningioma.SurgNeurolInt.2023Nov10;14:398.doi:10.25259/SNI7332023.PMID:38053699;PMCID:PMC10695471.

29 ChoiJW,QiaoY,MehtaTI,WilsonJN,TorigoeTH,TsappidiS,JonathanZhangY, Brown SC, HuiFK,AbruzzoT Safetyandefficacyofdynamiccatheterdirectedcerebraldigitalsubtractionangiographyfordiagnosisofbowhuntersyndromespectrumdisorders:Asystematicreviewoftheliterature.Interv Neuroradiol.2024Mar13:15910199241236820.doi:10.1177/15910199241236820.Epubaheadofprint.PMID:38477583.

30.Choi,JW;Ishikawa,K;Bellatti,S;Ahn,HY; Brown, SC.InvestigatingRacial/EthnicDisparitiesandAssociatedRiskFactorsofPost-traumaticEpilepsy FollowingTraumaticBrainInjuryinHawai’i.AmericanAcademyofNeurology.

31.Choi,JW;Jin,K; Brown, SC.MesiotemporalInvolvementinNeurosyphilis.AmericanAcademyofNeurology.

32.ColemanD, Kuwada S.miRNAasaBiomarkerfortheEarlyDetectionofColorectalCancer.Genes(Basel).2024Mar5;15(3):338.doi: 10.3390/genes15030338.PMID:38540397;PMCID:PMC10969835.

33 DaleML,AliF,AndersonA, Bruno M,ComeauM,DiazK,GolbeLI,HonigLS,SchmidtM,SpearsC,ShurerJ Patientswithprogressivesupranuclearpalsy needtobeseensoonerandmorefrequently.(2023).ParkinsonismandRelatedDisorder,116.doi:10.1016/j.parkreldis.2023.105883.Epub2023Oct4. PMID:37806807.

34.DanpanichkulP,WattanachayakulP,DuangsonkK, Ongsupankul S,SripusanapanA,UawithyaE,BenjanuwattraJ,TrongtorsakA,NathisuwanS, NavaravongL.Theburdenofalcohol-relatedcardiovascularcomplicationsinyoungandmiddle-agedadults:risingburdenofatrialfibrillationand hypertensiveheartdisease.ActaCardiol.2024Jul;79(5):549-556.doi:10.1080/00015385.2024.2346872.Epub2024May3.PMID:38699921.

35. Daoud EG,LeeP,TomaS,FranckCL.Meanairwaypressure–Minuteventilationproduct(mM):Asimpleanduniversalsurrogateequationtocalculate mechanicalpowerinbothvolumeandpressurecontrolledventilation.JMechVent2024;5(2):46-55.

36.EbinaK,HiranoT,MaedaY,OkitaY,EtaniY,HiraoM,YamamotoW,HashimotoM,MurataK,OnishiA, Jinno S,HaraR,SonY,AmuroH,KotaniT,ShibaH, KatayamaM,YamamotoK,KumanogohA,OkadaS,NakataK.Add-oneffectivenessofmethotrexateoriguratimodinpatientswithrheumatoidarthritis exhibitinganinadequateresponsetoJanuskinaseinhibitors:TheANSWERcohortstudy ModRheumatol 2023Jul4;33(4):690-699 doi: 10.1093/mr/roac092.PMID:35962543.

37.Fajardo-CampoverdiA,Mamani-CruzL,Ibarra-EstradaM,Maldonado-BeltranI,RoncalliA, Daoud EG.Cyclicenergy:thetranscendentalrelevanceof respiratoryrate.AretrospectiveobservationalstudywithBayesiananalysisJMechVent2023;5(1):1-10.

38.FarinaJM, Yinadsawaphan T,JaroszewskiDE,AlyMR,BotrosM,CheemaKP,FatundeOA,SorajjaD.Theelectrocardiographicmanifestationsofpectus excavatumbeforeandaftersurgicalcorrection.JElectrocardiol.2024Jan-Feb;82:19-26.doi:10.1016/j.jelectrocard.2023.11.007.Epub2023Nov19.PMID: 38000149.

39.Fernandez-de-Las-PenasC,Torres-MachoJ,CatahayJA,MacasaetR,VelascoJV, Macapagal S,CaldararoM,HenryBM,LippiG,Franco-MorenoA,Notarte KI.Correction:IsantiviraltreatmentattheacutephaseofCOVID-19effectivefordecreasingtheriskoflong-COVID?Asystematicreview.Infection.2024Mar 7.doi:10.1007/s15010-024-02208-x.Epubaheadofprint.Erratumfor:Infection.2024Feb;52(1):43-58.doi:10.1007/s15010-023-02154-0.PMID: 38451416

40.FranckCL, Daoud EG.Effectsofthepronepositionongasexchangeandventilatorymechanicsandtheircorrelationswithmechanicalpowerinburn patientswithARDS. JMechVent2023;5(1):21-29

41.FujiuchiB,DaoudEG.SMARTTriggerversusFlowandPressuretriggerperformanceduringauto-PEEP.JMechVent2023;4(3):108-113.

42.GandhiZJ,DugarS, Sato R.DoIalwaysneedacentralvenouscathetertoadministervasopressors?CleveClinJMed.2024May1;91(5):287-291.doi: 10.3949/ccjm.91a.23033.PMID:38692697.

43 Goo C,MordenF,WongK,AquinoS,KawamuraJ,RubelV,MascaS,GorenfloR, CarrazanaE, Liow K FamiliarityandPerceptionsofAducanumabin Caregiversof HawaiiAlzheimer'sDiseasePatients:ResultsofaTelephoneSurvey.Cureus.2023Dec 5;15(12):e50001.doi:10.7759/cureus.50001.PMID: 38186481;PMCID:PMC10767469.

44. Gozun M, Nishimura Y, Techasatian W, Pham A, Benavente K, KewcharoenJ.Theriskofnewheartfailureassociatedwithproteaseinhibitor: Systematicscopingreview.IntJSTDAIDS.2023Dec;34(14):1053-1061.doi:10.1177/09564624231196599.Epub2023Aug22.PMID:37608625.

45. Gozun M, Vu K, Nishimura Y, GhukasyanH,ZhangJ, Kemble-Luo A, Singh D.CliffdivingleadingtocommotiocordisinapatientwithEbstein'sanomaly. JCardiolCases.2023Sep1;28(6):250-252.doi:10.1016/j.jccase.2023.08.012.PMID:38126049;PMCID:PMC10730268.

46.Gu,H.,Zhang,C.,Yu,Z., Rettenmeier, C., Stenger, V. A.,&Akçakaya,M.(2024,May).Non-CartesianSelf-SupervisedPhysics-DrivenDeepLearning ReconstructionforHighly-AcceleratedMulti-EchoSpiralfMRI.In2024IEEEInternationalSymposiumonBiomedicalImaging(ISBI)(pp.1-5).IEEE.

47.GullapalliD,GantiSS, Bhopalwala H,DewaswalaN,BhopalwalaA,KommineniS,AliM,VangaraA.HowMuchIsEnough?ACaseofDigoxinToxicity. Chest.2023;164:A2998.doi:10.1016/j.chest.2023.07.1962.

48.HagiyaH, Nishimura Y,OtsukaF.SafetyandusefulnessofnebulizedliposomalamphotericinB:Systematicscopingreview.PulmPharmacolTher.2023 Oct;82:102233.doi:10.1016/j.pupt.2023.102233.Epub2023Jul4.PMID:37414132.

49 HaseR,SuzukiD,deLuiseC,ChenH,NonnenmacherE,HiguchiT,KatayamaK,KinjoM, Jinno S,MorishimaT,SugiyamaN,TanakaY,SetoguchiS Validity ofclaims-baseddiagnosesforinfectiousdiseasescommonamongimmunocompromisedpatientsinJapan.BMCInfectDis.2023Oct3;23(1):653.doi: 10.1186/s12879-023-08466-8.PMID:37789253;PMCID:PMC10548573.

50.HasegawaD, Sato R,DuggalA,SchleicherM,NishidaK,KhannaAK,DugarS.ComparisonofCentralandPeripheralArterialBloodPressureGradientsin CriticallyIllPatients:ASystematicReviewandMeta-Analysis.CritCareExplor.2024May24;6(6):e1096.doi:10.1097/CCE.0000000000001096.PMID: 38787296;PMCID:PMC11132324

51.HasegawaD,SharmaA,DugarS,LeeYI, Sato R.Mortalityofin-hospitalcardiacarrestamongpatientswithandwithoutprecedingsepsis:Anational inpatientsampleanalysis.JCritCare.2023Dec;78:154404.doi:10.1016/j.jcrc.2023.154404.Epub2023Aug28.PMID:37647817.

52. Hu J, Sonnleitner M, Weldon E, Kejriwal S, Brown B,ShahA.AnEscapeRoomtoTeachFirst-andSecond-YearMedicalStudentsNephrology.MedSci Educ.2023Oct13;34(1):71-76.doi:10.1007/s40670-023-01917-6.PMID:38510392;PMCID:PMC10948694.

53.HussainA,MarloweS,AliM,UyE, Bhopalwala H,GullapalliD,VangaraA,HaroonM,AkbarA,PiercyJ.ASystematicReviewofArtificialIntelligence ApplicationsintheManagementofLungDisorders.Cureus.2024Jan3;16(1):e51581.doi:10.7759/cureus.51581.PMID:38313926;PMCID:PMC10836179.

54. Jinno S,OnishiA,HattoriS,DubreuilM,UedaY,NishimuraK,OkanoT,YamadaH,YamamotoW,MurataK,OnizawaH,EbinaK,MaedaY,SonY,AmuroH, HaraR,HataK,ShibaH,KatayamaM,WatanabeR,HashimotoM,SaegusaJ.ComparisonofretentionofbiologicsinJapanesepatientswithelderly-onset rheumatoidarthritis-theANSWERcohortstudy Rheumatology(Oxford) 2024Feb6:keae081 doi:101093/rheumatology/keae081 Epubaheadofprint PMID:38317442.

55.KanitthamniyomC, Wannaphut C,PattanaprichakulP,KungwankiattichiS,OwattanapanichW.Organomegaliesasapredictiveindicatorofleukemia cutisinpatientswithacutemyeloidleukemia.PLoSOne.2024Feb16;19(2):e0297805.doi:10.1371/journal.pone.0297805.PMID:38363781;PMCID: PMC10871476.

56.KimNN,TanC,MaE,KutluS,CarrazanaE,VimalaV,ViereckJ, Liow K.Abnormal TemporalSlowingonEEGFindingsinPreclinicalAlzheimer'sDisease PatientsWiththe ApoE4Allele:APilotStudy.Cureus.2023Oct;15(10):e47852.doi: 10.7759/cureus.47852.eCollection2023Oct.PubMedPMID:38021568; PubMed CentralPMCID:PMC10679961.

57.KircherS,DuanF,AnN,GareenIF,SicksJD,SadighG,SugaJM,KehnH,MehanPT,BajajR,HansonDS,DaliaSM,AcobaJD,YasarDG,ParkER,WagnerLI, CarlosRC.Patient-ReportedFinancialBurdenofTreatmentforColonorRectalCancer.JAMANetwOpen.2024Jan2;7(1):e2350844.doi: 10.1001/jamanetworkopen.2023.50844.PMID:38194233;PMCID:PMC10777253.

58. Kiyokawa M,KanjaK.DatabaseVersusPatient-ThingstoConsiderwhenUtilizingtheHawai'iPrescriptionDrugMonitoringProgram.HawaiiJHealth SocWelf 2024Jan;83(1):29-31 PMID:38223465;PMCID:PMC10782391

59. Kiyokawa M,KwonAK,CapeMC,StreltzerJM.Kratomusedisorder:casereportsonsuccessfultreatmentwithhomeinductionofbuprenorphinenaloxone.FamPract.2023Nov23;40(4):596-598.doi:10.1093/fampra/cmad081.PMID:37499179.

60. Kozai L, Fujii-Lau L. Post-traumaticpancreaticobiliaryfistulaassociatedwithanintraductalpapillarymucinousneoplasm.GastrointestEndosc.2024 Feb;99(2):290-291 doi:101016/jgie202307017 Epub2023Jul7 PMID:37423528

61. Kuniyoshi J,HuangR,ChoiH, Bernas M, Techasatian W, Nishimura Y.ImmuneCheckpointInhibitor-InducedMyocarditisWithConcurrentMyasthenia Gravis.CanJCardiol.2023Nov;39(11):1646-1648.doi:10.1016/j.cjca.2023.06.007.Epub2023Jun15.PMID:37330137.

62. Lee AY, Jahansooz JR,GuittuD,SuzukiR,PakL,IshikawaKM, Goo C,ChenJJ, CarrazanaE,ViereckJ, Liow KK.BarrierstoAlzheimerDiseaseClinicalTrial ParticipationinaMinorityPopulation.CognBehavNeurol.2024Mar1;37(1):40-47.doi: 10.1097/WNN.0000000000000359.PubMedPMID:37878413; PubMedCentral PMCID:PMC10948321

63. Lee HH,YoshiokaR,WooMI,LiquardL,JahansoozJ, Weldon E, Lee A,IshikawaK,LittleN,CarrazanaE,ViereckJ, Liow K.Thesafetyandefficacyofdual calcitoningene-relatedpeptidetherapiesformigrainetreatment.Neurology.2024Apr;102(17Suppl1):3820.PresentedattheAmericanAcademyof NeurologyMeeting.

64 LewisMY,YonemoriK,RossA,WilkensLR,ShepherdJ,CasselK, Stenger A, Rettenmeier C,LimU,BousheyC,LeMarchandL EffectofIntermittentvs ContinuousEnergyRestrictiononVisceralFat:ProtocolforTheHealthyDietandLifestyleStudy2(HDLS2).Nutrients.2024May14;16(10):1478.doi: 10.3390/nu16101478.PMID:38794715;PMCID:PMC11123735.

65. Liow K,WhelessJW,CookDF,RabinowiczAL,CarrazanaE.DiazepamNasalSpray AdministrationIsEffectivetoControlSeizureClustersIrrespectiveOf TimeOfDay. FrontNeurol.2024May24;15:1335421.doi:10.3389/fneur.2024.1335421.PMID: 38854958;PMCID:PMC11157958.

66. Liow K.PharmacokineticsandTolerabilityofSingle-doseStaccato®AlprazolaminAdolescentswith EpilepsyandPopulationPKAnalysistoSupport DoseSelectioninAdolescents.American AcademyNeurologyMeeting,2024April.

67. Liow K.VNSinLennox-GastautSyndrome:Real-worldExperiencefromCORE-VNS(P3-1.014)

68.LyonsP,WhelessJ,VernerR,FerreiraJ, Liow K,ValerianoJ,MotamediGK.Neurology.2024Apr;102(17Suppl1):6902.PresentedattheAmerican AcademyofNeurologyMeeting

69.MaE,KreningE, Seto B, Bruno M.ChallengesFacedbyRuralHealthcareProvidersCaringforParkinson’sDiseasePatientsinNeighborIslandsofHawaiʻi. HawaiiJournalofHealthandSocialWelfare.2024;83(4):99-107.doi:10.62547/SGFP136.

70. Macapagal S, Wannaphut C, Takahashi T, Yinadsawaphan T, Nishimura Y, Acoba J. BlastoidMantleCellLymphomaPresentingasanOropharyngeal Mass Cureus 2024Mar18;16(3):e56378 doi:107759/cureus56378 PMID:38633973;PMCID:PMC11022918

71.MartinR,BuffensteinI,ChoD, Kiyokawa M.ToxidromeofanEasilyObtainableNootropic:ACaseReportofPhenibutIntoxicationandWithdrawal Delirium.JClinPsychopharmacol.2023Nov-Dec01;43(6):507-510.doi:10.1097/JCP.0000000000001759.Epub2023Sep12.PMID:37930202.

72 Martınez-MezaS,SinghB,NixonDF,DopkinsN, Gangcuangco LMA Thebrain-livercholinergicanti-inflammatorypathwayandviralinfections BioelectronMed.2023Dec20;9(1):29.doi:10.1186/s42234-023-00132-3.PMID:38115148;PMCID:PMC10731847.

73. Mercado, F. ImplementingPhenobarbitalProtocolinAlcoholWithdrawalSyndrome.HawaiiPacificEducationConferenceonFebruary10,2024at UniversityofHawaiiCollegeofMedicine.

74 MeropolSB,NorrisCJ,FronteraJA,AdeagboA,TroxelAB;COVID-19NeuroDatabank/BiobankConsortium TheNationalInstitutesofHealthCOVID-19 NeuroDatabank/Biobank:CreationandEvolution(Liow, K).Neuroepidemiology.2024Jun26:1-13.doi:10.1159/000539830.Epubaheadofprint.PMID: 38934169.

75. Miles, JD.Choosingreferencesources:Aninteractivetutorialformedicalstudents.OralpresentationattheAustralianandNewZealandAssociationfor HealthProfessionalEducators(ANZAHPE)2024annualconference.July4,2024,Adelaide,Australia.

76. Miles, JD.TeachingtheNeurologicalExambyIncludingAnimationsofExamFindingsinPBLCases.LightningTalkfortheInternationalAssociationof MedicalScienceEducators(IAMSE)VirtualForum2023.

77. Miles, JD.,&Paulo,F.NeurophobiaBeforeandafteraMedicalSchoolNeuroanatomyCourse.ePosterattheAMEE(AssociationforMedicalEducationin Europe)2023Conference.August26-30,2023.Glasgow,Scotland,UK.

78 Miles, JD.,&Petersen,J CreatingaDevicetoViewAxialSectionsofaHumanBraininNeuroanatomyLab PosterpresentationattheAustralianandNew ZealandAssociationforHealthProfessionalEducators(ANZAHPE)2024annualconference.July3,2024,Adelaide,Australia.

79. Miles, JD.,&Peterson,J.PrevalenceofneurologyasacoreclerkshipinLCME-accreditedUSallopathicmedicalschools.Posterpresentationatthe AustralianandNewZealandAssociationforHealthProfessionalEducators(ANZAHPE)2024annualconference.July2,2024,Adelaide,Australia.

80 Miles, JD ,&Yoshinaga,B Fictionalpatientsinproblem-basedlearningcaseswholookdifferentarediagnoseddifferently Posterpresentationatthe AustralianandNewZealandAssociationforHealthProfessionalEducators(ANZAHPE)2024annualconference.July2,2024,Adelaide,Australia.

81. Miles, JD.,AnimationsofNeurologicalExamFindingsCanBeUsedinMultiple-ChoiceQuestionsinStudentAssessments.Posterpresentationatthe HealthProfessionsEducationConference2024,February10,2024,Honolulu,HI.

82. Miles, JD.,Bow-Keola,J.,Putzler,D.,&Paulo,F.Spotthefakenews:evaluatingmedicalstudents'competencyinnavigatingmisinformation.Poster presentationattheAustralianandNewZealandAssociationforHealthProfessionalEducators(ANZAHPE)2024annualconference.July2,2024,Adelaide, Australia.

83. Miles, JD.,Putzler,D.,&Paulo,F.EvaluatingtheSpecificityoftheWarmWaterSubmersionTestforErythromelalgia.PosterpresentationattheAmerican AssociationofNeuromuscularandElectrodiagnosticMedicine2023AnnualMeeting,November1-4,2023.Phoenix,AZ.

84 Miles, JD ,StreamliningtheDevelopmentofComputerAnimationstoMoreRapidlySimulateNormalandAbnormalNeurologicalExamFindings Poster presentationattheHealthProfessionsEducationConference2024,February10,2024,Honolulu,HI.

85.MitchellBI,YazelEiserIE,KallianpurKJ, Gangcuangco LM, Chow DC, NdhlovuLC,PaulR, Shikuma CM.DynamicsofperipheralTcellexhaustionand monocytesubpopulationsinneurocognitiveimpairmentandbrainatrophyinchronicHIVinfection.JNeurovirol.2024Jun29.doi:10.1007/s13365-02401223-w.Epubaheadofprint.PMID:38949728.

86. Morgan, N.ImprovingCommunityNavigationforNativeHawaiianPatients.

87. Morihara C, Du W, Benavente K, Shimamoto R. Liver,lung,muscle,andbone:KlebsiellapneumoniaeinvasiveliverabscesssyndromeinaVietnamese immigrant IDCases 2023Sep7;34:e01893 doi:101016/jidcr2023e01893 PMID:37711882;PMCID:PMC10498160

88.MurakamiC, Lian K.GastricDiffuseLargeBcellLymphomaPresentingwithMassiveGastrointestinalBleeding.JGenIntMed.2024;39(Suppl 2):S137-1008.2

89.MurakamiC,MoonA, Lian K.The“Other”SalmonellaInfection.JGenIntMed.2023;38(Suppl2):S81-799.

90.NagarajG,VinayakS,KhakiAR,SunT,KudererNM,AboulafiaDM, Acoba JD,et.al;COVID-19andCancerConsortium.Clinicalcharacteristics,racial inequities,andoutcomesinpatientswithbreastcancerandCOVID-19:ACOVID-19andcancerconsortium(CCC19)cohortstudy.Elife.2023Oct 17;12:e82618.doi:10.7554/eLife.82618.PMID:37846664;PMCID:PMC10637772.

91.NagataM,MiyagiK,HernandezBY, Kuwada SK.MultiethnicTrendsinEarlyOnsetColorectalCancer.Cancers(Basel).2024Jan17;16(2):398.doi: 103390/cancers16020398 PMID:38254887;PMCID:PMC10814620

92. Nakagawa K,ChenR, Ross GW,DonlonTA,AllsoppRC,WillcoxDC,MorrisBJ,WillcoxBJ,MasakiKH.FOXO3longevitygenotypeattenuatestheimpactof hypertensiononcerebralmicroinfarctrisk.JHypertens.2024Mar1;42(3):484-489.doi:10.1097/HJH.0000000000003620.Epub2023Nov22.PMID: 38009316;PMCID:PMC10873049.

93. Nakata T,LiC,MayassiT,LinH,GhoshK,SegerstolpeA,DiamondEL,HerbstP,BiancalaniT,GaddamS,ParkarS,LuZ,JaiswalA,LiB,CreaseyEA, LefkovithA,DalyMJ,GrahamDB,XavierRJ GeneticvulnerabilitytoCrohn'sdiseaserevealsaspatiallyresolvedepithelialrestitutionprogram SciTransl Med.2023Oct25;15(719):eadg5252.doi:10.1126/scitranslmed.adg5252.Epub2023Oct25.PMID:37878672;PMCID:PMC10798370.

94.NakayamaY,WatanabeR,YamamotoW,EbinaK,HiranoT,KotaniT,ShibaH,KatayamaM,SonY,AmuroH,OnishiA, Jinno S,HaraR,MurakamiK, MurataK,ItoH,TanakaM,MatsudaS,MorinobuA,HashimotoM.IL-6inhibitorsandJAKinhibitorsasfavourabletreatmentoptionsforpatientswith anaemiaandrheumatoidarthritis:ANSWERcohortstudy.Rheumatology(Oxford).2024Feb1;63(2):349-357.doi:10.1093/rheumatology/kead299.PMID: 37354495

95. Nishimura Y, KhanM,LeeB, Arayangkool C,ZhangJ,PalanisamyA, Banerjee D, Izutsu C.Definingoptimalbloodpressurecontrolforpre-transplant end-stagerenaldiseasepatients:scopingreview.BloodPressMonit.2023Dec1;28(6):316-321.doi:10.1097/MBP.0000000000000668.Epub2023Aug2. PMID:37910025.

96.OsorioJ,ZeiPC,DıazJC,VarleyAL,MoralesGX,SilversteinJR,OzaSR,D'SouzaB, Singh D,MorettaA,MetzlMD,HoyosC,MatosCD,RiveraE,MagnanoA, SalamT,NazariJ,ThorneC,CosteaA,ThosaniA,RajendraA,RomeroJE.High-FrequencyLow-TidalVolumeVentilationImprovesLong-TermOutcomesinAF Ablation:AMulticenterProspectiveStudy.JACCClinElectrophysiol.2023Aug;9(8Pt2):1543-1554.doi:10.1016/j.jacep.2023.05.015.Epub2023May18. PMID:37294263.

97.ParekhM,DewaswalaN,CaoX,ArbuneA, Bhopalwala H,PatelR.ManagementDilemmaofMetastaticColorectalCancerintheSettingofaSuspected Bevacizumab-InducedAorticDissection.Chest.2023;164:A3554-A3555.doi:10.1016/j.chest.2023.07.2310.

98.ParkJ,DeanLS,HecklJ, Gangcuangco LM,PedroTK, Tallquist MD, Seto TB,ShiramizuB, Chow DC, Shikuma CM.Low-densitygranulocytesdisplay immaturecellswithenhancedNETformationinpeoplelivingwithHIV.SciRep.2023Aug16;13(1):13282.doi:10.1038/s41598-023-40475-0.PubMed PMID:37587169;PubMedCentralPMCID:PMC10432506.

99.ParkJO,Lee-JayaramJ,SatoE,EtoY,Kahili-HeedeM,HirayamaK, Berg BW.Ascopingreviewofremotefacilitationduringsimulation-basedhealthcare education BMCMedEduc 2023Aug21;23(1):592 doi:101186/s12909-023-04551-3 PMID:37605196;PMCID:PMC10464104

100. Parsa AA,AzamaKA,VawerM,OnaMA,SetoTB.PrevalenceStudyofMASLDinAdolescentandYoungAdultPacificIslandersandAsiansLivingin Hawai'i.JEndocrSoc.2024Jan18;8(3):bvad165

101 Parsa AA,AzamaKA,VawerM,OnaMA, Seto TB PrevalenceStudyofMASLDinAdolescentandYoungAdultPacificIslandersandAsiansLivingin Hawai'i.JEndocrSoc.2024Jan18;8(3):bvad165.doi:10.1210/jendso/bvad165.PMID:38249431;PMCID:PMC10797323.

102. Parsa AA,GharibH.ThyroidNodules:Past,Present&Future.EndocrPract.2024Jun14https://doi.org/10.1016/j.eprac.2024.05.016

103.Petersen,J.& Miles, JD.IncorporationoftheNeurologicalExaminationintoaMedicalSchoolNeuroanatomyCourse.ePosterattheAMEE(Association forMedicalEducationinEurope)2023Conference August26-30,2023 Glasgow,Scotland,UK

104. Pham A,KeitokuK, Devendra G, Ikeda R.PredictingtheSuccessofHFNCforTreatingARDSduetoCOVID-19:TheroleofInflammatoryBiomarkers. Chest.2024;164(4):A1768.

105. Pham A,KeitokuK, Devendra G, Ikeda R.SerialBiomarkerMeasurementsMayBeHelpfultoPredicttheSuccessfulApplicationofHighFlowNasal Cannula(HFNC)inCOVID-19Pneumonia(abstract) AmJRespirCritCareMed2024;209:A3491

106. Phrampus PE, Berg BW.ResponsetoRecoveringFromAdversity-DoWeNeedtoProtectOurLearners?SimulHealthc.2024Apr1;19(2):132.doi: 10.1097/SIH.0000000000000787.Epub2024Feb26.PMID:38421357.

107.PruszczykA,ZawadkaM,AndruszkiewiczP,LaViaL,HerpainA, Sato R,DugarS,ChewMS,SanfilippoF.Mortalityinpatientswithseptic cardiomyopathyidentifiedbylongitudinalstrainbyspeckletrackingechocardiography:Anupdatedsystematicreviewandmeta-analysiswithtrial sequentialanalysis AnaesthCritCarePainMed 2024Apr;43(2):101339 doi:101016/jaccpm2023101339 Epub2023Dec19 PMID:38128732

108.QarajehA,TangpanithandeeS,ThongprayoonC,SuppadungsukS,KrisanapanP, Aiumtrakul N,GarciaValenciaOA,MiaoJ,QureshiF,Cheungpasitporn W.AI-PoweredRenalDietSupport:PerformanceofChatGPT,BardAI,andBingChat.ClinPract.2023Sep26;13(5):1160-1172.doi: 10.3390/clinpract13050104.PMID:37887080;PMCID:PMC10605499.

109 RobertsonDJ,DominitzJA,BeedA Manlolo J CONFIRMStudyGroup BaselineFeaturesandReasonsforNonparticipationintheColonoscopyVersus FecalImmunochemicalTestinReducingMortalityFromColorectalCancer(CONFIRM)Study,aColorectalCancerScreeningTrial.JAMANetwOpen.2023Jul 3;6(7):e2321730.doi:10.1001/jamanetworkopen.2023.21730.Erratumin:JAMANetwOpen.2023Aug1;6(8):e2330304.doi: 10.1001/jamanetworkopen.2023.30304.PMID:37432690;PMCID:PMC10336619.

110.SanchezJ,WoodsC,ZagrodzkyJ,NazariJ,SingletonMJ,SchrickerA,RuppertA,BrumbackB,JennyB,AthillC,JosephC,ShahD,UpadhyayG,KulstadE, Cogan J...AtrioesophagealFistulaRatesBeforeandAfterAdoptionofActiveEsophagealCoolingDuringAtrialFibrillationAblation.JACCClinElectrophysiol. 2023Dec;9(12):2558-2570.doi:10.1016/j.jacep.2023.08.022.Epub2023Sep20.PMID:37737773.

111.SantiBM, Verhoef PA.COVID-19HospitalizationinHawai'iandPatternsofInsuranceCoverage,RaceandEthnicity,andVaccination.JAMANetwOpen. 2024May1;7(5):e243696.doi:10.1001/jamanetworkopen.2024.3696.PMID:38691362;PMCID:PMC11063802.

112.SantonocitoC, Sato R,DugarS,SanfilippoF.Theimportanceofassessingleftventricularlongitudinalfunctioninpresenceofincreasedafterload.Crit Care 2024Jan12;28(1):21 doi:101186/s13054-024-04801-w PMID:38217007;PMCID:PMC10785471

113.SaowapaS,PolpichaiN,SiladechP, Wannaphut C, Tanariyakul M,WattanachayakulP,LalitnithiP.EvaluatingKaposiSarcomainKidneyTransplant Patients:ASystematicReviewandMeta-Analysis.Cureus.2024Jan18;16(1):e52527.doi:10.7759/cureus.52527.PMID:38371002;PMCID:PMC10874301.

114. Sato R,HasegawaD,GuoSC,NishidaK,DugarS.INVASIVEHEMODYNAMICMONITORINGWITHPULMONARYARTERYCATHETERINSEPSISASSOCIATEDCARDIOGENICSHOCK.Shock.2024May1;61(5):712-717.doi:10.1097/SHK.0000000000002290.Epub2023Dec18.PMID:38150363.

115 Sato R,HasegawaD, Guo SC,NishidaK,DugarS TemporaryMechanicalCirculatorySupportinSepsis-AssociatedCardiogenicShockWithandWithout AcuteMyocardialInfarction.JCardiothoracVascAnesth.2024Jan;38(1):207-213.doi:10.1053/j.jvca.2023.09.026.Epub2023Sep23.PMID:37852913.

116 Sato R,SanfilippoF,HasegawaD,PrasitlumkumN,DuggalA,DugarS Prevalenceandprognosisofhyperdynamicleftventricularsystolicfunctionin septicpatients:asystematicreviewandmeta-analysis.AnnIntensiveCare.2024Feb3;14(1):22.doi:10.1186/s13613-024-01255-9.PMID:38308701; PMCID:PMC10838258.

117. Seto BK,TsaiPI, Khan Z, Seto TB.ImpactofMoreDetailedMeasuresofDiseaseSeverityonRacialDisparitiesinCardiacSurgeryMortalityamong NativeHawaiiansandPacificIslanders.HawaiiJHealthSocWelf.2023Oct;82(10Suppl1):84-88.PMID:37901671;PMCID:PMC10612420.

118. Shikuma CM,WojnaV,DeGruttolaV,SiriwardhanaC, Souza SA,Rodriguez-BenitezRJ,TurnerEH,KallianpurK,BolzeniusJ, Chow D,MatosM, ShiramizuB,ClementsDM,PremeauxTA,NdhlovuLC,PaulR.ImpactofantiretroviraltherapyintensificationwithC-Cmotifchemokinereceptor5 antagonistmaraviroconHIV-associatedneurocognitiveimpairment.AIDS.2023Nov1;37(13):1987-1995.doi:10.1097/QAD.0000000000003650.Epub 2023Jul6.PMID:37418541;PMCID:PMC10538417.

119. Shiraishi K, Chesta F, Nishimura Y, Chong CM.BilateralRenalVeinThrombosisandChylousAscitesinPhospholipaseA2Receptor-Associated MembranousNephropathy:ACaseReport Cureus 2024Jun29;16(6):e63434 doi:107759/cureus63434 PMID:39077230;PMCID:PMC11284508

120. Shiraishi K,MorleyMP,JonesDL,ZhaoG,WeinerAI,BasilMC,CantuE,FergusonLT,OysterM,BabuA,YingY,ZhouS,LiS,VaughanAE,MorriseyEE. AirwayepithelialcellidentityandplasticityareconstrainedbySox2duringlunghomeostasis,tissueregeneration,andinhumandisease.NPJRegenMed. 2024Jan5;9(1):2.doi:10.1038/s41536-023-00344-w.PMID:38182591;PMCID:PMC10770358.

121 ShirasugiI,OnishiA,NishimuraK,YamamotoW,MurakamiK,OnizawaH,MaedaY,EbinaK,SonY,AmuroH,KatayamaM,HaraR,NagaiK,HiramatsuY, HashimotoM,OkanoT,MaedaT,HayashiS,SendoS, Jinno S,YamamotoY,YamadaH,UedaY,SaegusaJ.Associationoflargejointinvolvementatthestartof biologicaldisease-modifyingantirheumaticdrugsandJanuskinaseinhibitorswithdiseaseactivityanddrugretentioninpatientswithrheumatoidarthritis: TheANSWERcohortstudy.IntJRheumDis.2024Mar;27(3):e15097.doi:10.1111/1756-185X.15097.PMID:38439176.

122.SiriwardhanaC,CarrazanaE, Liow K,ChenJJ.Racial/EthnicDisparitiesinthe Alzheimer'sDiseaseLinkwithCardioandCerebrovascularDiseases, BasedonHawaii MedicareData.JAlzheimersDisRep.2023;7(1):1103-1120.doi:10.3233/ADR230003.eCollection2023.PubMedPMID:37849625; PubMedCentralPMCID: PMC10578323

123. Snyder E, Nakamura R,OgawaM,BersaminK, Weldon E, Jahansooz J, Lee A,IshikawaK,AbramowitzJ,CarrazanaE,ViereckJ, Liow K.Factors AssociatedwithDepressionRiskinPost-ConcussiveSyndromePatientsinHawaii.Presentedat:AmericanNeuropsychiatricAssociation34thAnnual Meeting;March8,2024;Houston,TX.

124 StephensSB,ShalhubS,DoddN,LiJ,HuangM,OdaS,KancherlaK,DoanTT,PrakashSK,WeigandJD,AschFM,BeecroftT,CecchiA,ShittuT,PreissL, LeMaireSA,DevereuxRB,PyeritzRE,HolmesKW,RomanMJ,LacroRV, Shohet RV,KrishnamurthyR,EagleK,ByersP,MilewiczDM,MorrisSA.Vertebral TortuosityIsAssociatedWithIncreasedRateofCardiovascularEventsinVascularEhlers-DanlosSyndrome.JAmHeartAssoc.2023Oct3;12(19):e029518. doi:10.1161/JAHA.123.029518.Epub2023Sep30.PMID:37776192;PMCID:PMC10727246.

125.SugiyamaN,KinjoM, Jinno S,deLuiseC,MorishimaT,HiguchiT,KatayamaK,ChenH,NonnenmacherE,HaseR,SuzukiD,TanakaY,SetoguchiS. Validationofclaims-basedalgorithmsforrheumatoidarthritisinJapan:ResultsfromtheVALIDATE-Jstudy IntJRheumDis 2024Jan;27(1):e15001 doi: 10.1111/1756-185X.15001.Epub2023Dec31.PMID:38160436.

126.TakaokaK,TomaS,LeeP, Daoud EG. AcomparativeanalysisofmechanicalpowerandItscomponentsinpressure-controlledventilationmodeand AVM-2mode.JMechVent2023;4(4):130-140.

127 TakaokaK,VenkataramanA,MoriharaC, Tan A,TechasatianW DesmoplasticSmallRoundCellTumorsPresentedWithST-SegmentElevation MyocardialInfarctionandCardiacTamponadeinaYoungAdultFemale:ACaseReport.Cureus.2024Jan31;16(1):e53333.doi:10.7759/cureus.53333.PMID: 38435931;PMCID:PMC10905209.

128. Tan AJ,NakataT,TanSK,ChangJY, Murakami TT.P3998-JackhammerEsophagusandAltoids:PeppermintOilforSymptomaticReliefin HypercontractileEsophagus.ACG2024AnnualScientificMeetingAbstracts.Philadelphia,PA:AmericanCollegeofGastroenterology.

129. Tan AJ,NakataT,TanSK, Murakami TT.P5004-CysticFibrosisandRecurrentDistalIntestinalObstructionSyndrome.ACG2024AnnualScientific MeetingAbstracts.Philadelphia,PA:AmericanCollegeofGastroenterology.

130. Tan AJ,TanSK,NebrejasK,HamadeN,MurakamiTT.P4801-BoochorHooch:ExcessiveKombuchaIntakeMimickingAlcoholicHepatitis.ACG2024 AnnualScientificMeetingAbstracts.Philadelphia,PA:AmericanCollegeofGastroenterology.

131. Tanariyakul M... Acoba JD.Clinicalcharacteristicsofrenalcellcarcinomainthetransplantedkidneyinrenaltransplantrecipients:Asystematic scopingreview.AmericanSocietyofClinicalOncology,AnnualMeeting,Chicago,IL,2024.Abstract#e16518.

132 Tanoue M EchoProtocolforPatientsPresentingwithStroke Presentedat:ACC;2024Jan24;Chicago(IL)

133. Techasatian W, Gozun M, Morihara C, Pham A, Benavente K, Nagamine T, Nishimura Y. Hamartomaofmaturecardiacmyocytes:systematic review.CardiovascPathol.2023Jul-Aug;65:107538.doi:10.1016/j.carpath.2023.107538.Epub2023Apr7.PMID:37031829.

134. Techasatian W, Gozun M, Vo K, YokoyamaJ, Nagamine T, Shah P, Vu K, ZhangJ, Nishimura Y.Eosinophilicmyocarditis:systematicreview.Heart. 2024Apr25;110(10):687-693 doi:101136/heartjnl-2023-323225 PMID:37963727

135. Techasatian W, Nishimura Y, Tanariyakul M, Morihara C, Arayangkool C, SettleA, Aiumtrakul N,KewcharoenJ.IntravenousIronforHeartFailure: UpdatedSystematicReviewandMeta-Analysis.Angiology.2023Nov2:33197231213181.doi:10.1177/00033197231213181.Epubaheadofprint.PMID: 37916421.

136.Techasatian W, Pham A, Nishimura Y, Banerjee D. LeftVentricularOutflowTractObstructionDuetoCardiacHamartoma.Cureus.2024Jun 19;16(6):e62721 doi:107759/cureus62721 PMID:39036200;PMCID:PMC11259457

137.Vares-LumDL, Gangcuangco LMA,ParkJ,ManzanoEJr,OrtegaM, Chow DC, Shikuma C.Plasmagalectin-3isassociatedwithdecreasedglomerular filtrationrateinchronicHIV.HIVResClinPract.2023Sep20;24(1):2261753.Epub2023Oct2.PMID:37783570;PMCID:PMC10695702.

138. Vassar M,LewisSJ.RESPONSE:PsychologicalSafetyforCardiologyTrainees.JAmCollCardiol.2023Nov21;82(21):2066-2067.doi: 101016/jjacc202302056 Epub2023Oct26 PMID:37968023

139. Verhoef PA.“ImmuneDysregulationDuringSepsis”inHall,Schmidt,andWood’sPrinciplesofCriticalCare,ed.G.Schmidt,JPKressandISDouglas, McGrawHill,2023.

140. Verhoef PA. S1PR2:AFulcrumintheBalanceofType1andType2ResponsesduringSepsis-inducedAcuteLungInjury.AmJRespirCellMolBiol.2024 Mar;70(3):157-158 doi:101165/rcmb2023-0433ED PMID:38226863;PMCID:PMC10914765

141.WaitayangkoonP,LeesutipornchaiT, Techasatian W, Aiumtrakul N, Tanariyakul M, Arayangkool C,KanthajanT, Nagamine T,KewcharoenJ.Urateloweringtherapyisassociatedwithareducedriskofarrhythmias:asystematicreviewandmeta-analysis.JRheumDis.2024Apr1;31(2):108-115.doi: 10.4078/jrd.2023.0059.Epub2023Dec28.PMID:38559794;PMCID:PMC10973354.

142. Wannaphut C, Nishimura Y, DuW,KookanokC,WataiT,ChongC.ReversibleCerebralVasoconstrictionSyndromeMimickingEclampsia.Cureus.2024 Mar27;16(3):e57021.doi:10.7759/cureus.57021.PMID:38681466;PMCID:PMC11046369.

143. Wannaphut C,TakahashiT, Macapagal S,TanariyakulM,OngsupankulS,YinadsawaphanT, Nishimura Y, Acoba J.TonsillarMetastasisof HepatocellularCarcinoma:ACaseReportandReviewoftheLiterature.Cureus.2024Apr14;16(4):e58250.doi:10.7759/cureus.58250.PMID:38745806; PMCID:PMC11093587.

144 Wannaphut C... Acoba JD Effectoncardiovascularoutcomeofsodium-glucoseco-transporter-2(SGLT2)inhibitorsamongpatientswithcancertreated withanthracycline:Asystematicreviewandmeta-analysis.AmericanSocietyofClinicalOncology,AnnualMeeting,Chicago,IL,2024.Abstract#e2400.

145. Weldon EJ, Nakamura RW, Van T, Goo C, Lee AY, Jahansooz JR,CarrazanaE, Liow KK.ExerciseandRecoveryFollowingMild-to-ModerateTraumatic BrainInjuryinthe CommunitySetting.Cureus.2024Feb;16(2):e53459.doi:10.7759/cureus.53459.eCollection2024Feb.PubMedPMID:38435185; PubMed CentralPMCID:PMC10909398.

146 WongMC,BennettJP,QuonB,LeongLT,TianIY,LiuYE,KellyNN,McCarthyC, Chow D,PujadesS,GarberAK,MaskarinecG,HeymsfieldSB,ShepherdJA AccuracyandPrecisionof3-dimensionalOpticalImagingforBodyCompositionbyAge,BMI,andEthnicity.TheAmericanJournalofClinicalNutrition.2023 Sep;118(3):657-671.DOI:10.1016/j.ajcnut.2023.07.010.PMID:37474106.

147.YeY,NocheRB,SzejkoN,BothCP,AcostaJN,LeasureAC, Brown SC,ShethKN,GillTM,ZhaoH,FalconeGJ.Agenome-wideassociationstudyoffrailty identifiessignificantgeneticcorrelationwithneuropsychiatric,cardiovascular,andinflammationpathways.Geroscience.2023Aug;45(4):2511-2523.doi: 101007/s11357-023-00771-z Epub2023Mar16 PMID:36928559;PMCID:PMC10651618

148.YokoyamaJ,DiepS, Kiyokawa M,OnoyeJ.InhalantScreeninginEarlyAdolescence:MissedOpportunitytoPreventEscalationtoPolysubstanceUseand RelatedConsequences.PrimCareCompanionCNSDisord.2024Apr25;26(2):23cr03676.doi:10.4088/PCC.23cr03676.PMID:38684010.

149.YoonH,DeanSD,JiyaromB,KhadkaVS,DengY,Nerurkar,VR, Chow DC, Shikuma CM, Devendra G,KohY,ParkJ.Single-cellRNAsequencingreveals characteristicsofmyeloidcellsinpost-acutesequelaeofSARS-CoV-2patientswithpersistentrespiratorysymptoms FrontImmunol2024Jan8:14:1268510 doi:10.3389/fimmu.2023.1268510.eCollection2023.PMID:38259488PMCID:PMC10800799.

150.YoshikawaGT,MiyazakiKS, Acoba JD,FujiiT.Racialandsurvivaldisparitiesininflammatorybreastcancer(IBC)andnon-IBC:apopulation-basedstudy focusedonNativeHawaiiansandotherPacificIslanders.FrontOncol.2024May17;14:1390080.doi:10.3389/fonc.2024.1390080.PMID:38826792;PMCID: PMC11140018.

151 YouJY, Sato R,ChawlaS,KapoorA,WangX,CollierP,AuzingerG,DuggalA,DugarS Hemodynamicprofileofcirrhoticpatientswithsepsisandseptic shock:Apropensityscorematchedcase-controlstudy.JCritCare.2024Jun;81:154532.doi:10.1016/j.jcrc.2024.154532.Epub2024Feb8.PMID:38330737.

152.ZhaoJO,PatelBK,KrishackP,StutzMR,PearsonSD,LinJ,Lecompte-OsorioPA,DuganKC,KimS,GrasN,PohlmanA,KressJP,HallJB,SperlingAI, AdegunsoyeA, Verhoef PA,WolfeKS.(2023)“IdentificationofClinicallySignificantCytokineSignatureClustersinPatientsWithSepticShock.”CritCareMed. Dec1;51(12):e253-263;.doi:10.1097/CCM.0000000000006032.

FACULTY CLINICAL FACULTY

GRANTS +

1. A Phase 2 Randomized, Open-Label, Active-Controlled Study Evaluating the Safety and Efficacy of an Oral Weekly Regimen of Islatravir in Combination With Lenacapavir in Virologically Suppressed... PI: Shikuma C. FundedbyGileadSciences,Inc.,$4,310,416awardedon4/28/2023.Project period:3/16/2023-11/30/2026.

2. Administrative Supplements to Enhance Inclusion of Native Hawaiian/Other Pacific Islander Populations in Minority Health and Health Disparities Research. PI: Chow, D. FundedbyNIH;$125,000awardedon09/01/2021.Projectperiod:09/01/2021-08/30/2023.

3 ADR SUPP - BRIDGE - BOISVERT TECHNICIAN. PI: Boisvert, W. Intramurallyfunded;$70,000awardedon07/07/2023 Projectperiod:07/01/202306/30/2024

4. American Lung Association of Hawaii and Leahi Fund Endowed Chair in Respiratory Health. Director: Ikeda R. Fundedlocally;$39,381.60awarded on12/03/2021.Projectperiod:12/03/2021-12/02/2024.

5. Building and Implementing Data Capacity for Improving Quality and Equity at Queen’s (BUILD IQ-EQ). Co-PI: Seto, T. FundedbyPCORI;$499,983 awardedon08/01/2023.Projectperiod:08/01/2023-12/31/2025.

6. Calcium Channel SNPrs1006737: characterizing the genetic risks in MUD (Methamphetamine Use Disorder). Other: Kiyokawa, M. FundedbyNIH; $218,250awardedon09/30/2023.Projectperiod:09/30/2023-09/29/2024.

7. CDC Paul Coverdell Acute Stroke Program. PI: Koenig, M.FundedbyCDC;$1,800,000awardedon08/01/2021.Projectperiod:08/01/202107/31/2025.

8 Center of Care. PI: Bruno, M Projectperiod:07/23-06/25

9. Center of Excellence, The Multiple System Atrophy (MSA) Coalition. PI: Bruno, M. Projectperiod:11/23-10/25.

10.COBRE-Diabetes, Phase II Research Project. PI: Brown, S. Intramurallyfunded;$1,369,375awardedon05/01/2024.Projectperiod:05/01/202404/30/2029.

11.Comprehensive Care Center, Parkinson’s Foundation, PF-CCC-1260182. PI: Bruno M. Projectperiod:12/23-11/28.

12. COVID19 Infection in Hawaii. Co-PI: Chow, D. Locallyfunded;$150,000awardedon09/01/2021.Projectperiod:09/01/2021-08/30/2024.

13. Creative Pedagogy Award (research). PI: Miles, J. Intramurallyfunded;$3,000awardedon04/30/2023.Projectperiod:07/01/2023-06/30/2024.

14. Directed evolution of a sequence-specific targeting technology... Other: Shohet, R. FundedbyNIH;awardedon4/1/2021;projectperiod 04/01/2021-03/31/2025

15. Disparities in Care of Parkinson’s Disease Patients Among Asian Americans, Native Hawaiian, and Pacific Islanders: A Retrospective Analysis of Hospitalization and Pilot Study for a Prospective Longitudinal Cohort (RA-2021-040). Michael J. Fox Foundation “Promoting Diversity, Equity and Inclusion in Parkinson’s Disease” grant. PI: Bruno, M. Projectperiod:01/22-01/25.

16. Effect of Immulina Supplements on Inflammatory Biomarkers Correlated With Clinical Symptoms in Patients With Long COVID (PASC). PI: Shikuma, C. FundedbytheUniversityofMississippi;$12,500awardedon1/17/2024.Projectperiod:12/1/2022-7/31/2023.

17. Effects of Intermittent Energy Restriction on Intra-Abdominal Fat and the Gut Microbiome: A Randomized Trial. Other: Stenger, A. PI: LeMerchand.FundedbyNIH,$2,500,000awardedon09/21/2021.Projectperiod09/21/2021-08/31/2026.

18 Evaluating Sexual Dimorphism in a Mouse Model of Methamphetamine Cardiomyopathy. Other: Shohet, R. FundedbyAHA;$70,000awardedon 04/01/2024.Projectperiod:04/01/2024-03/31/2026.

19. Evaluating Sexual Dimorphism in a Mouse Model of Methamphetamine Cardiomyopathy. Other: Shohet, R. FundedbyOlaHawai'i;$50,000 awardedon07/01/2024.Projectperiod:07/01/2024-06/30/2025.

20 Evaluation of treatment predictors reflecting beta-catenin activation in hepatocellular carcinoma. Other: Rettenmeier, C. FundedbyNIH; $2,600,000awardedon6/24/2021;projectperiod07/01/2021-06/30/2026.

21. Facilitating Patient Success in Colorectal Cancer Prevention among Pacific Islanders. Co-PI: Kuwada, S. FundedbyNIH;$360,000awardedon 05/01/2024.Projectperiod:07/01/2024-06/30/2027.

22 Facilitators and barriers to implementation of a pilot methamphetamine treatment program at a Level I trauma center. Co-PI: Kiyokawa, M. Fundedlocally.$14,575awardedon6/13/2022;projectperiod07/01/2022-01/01/2024.

23. Factors Responsible for the Development of Pulmonary Post-Acute Sequelae of SARS-CoV-2 Infection (PPASC) in Hawaii. PI: Devendra, G. FundedbyNIH;$2,300,000awardedon9/1/2022.Projectperiod:9/1/2022-5/31/2027.

24. Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps. PI: Kuwada, S. FundedbyNRG-CC005;$17,000awardedon 12/11/2023 Projectperiod:12/11/2023-12/10/2028

25. Global Parkinson’s Genetics Program. PI: Bruno, M. FundedbytheMichaelJ.FoxFoundation.Projectperiod:01/24-12/25.

26. Hawai’i Clinical Research Network for Health Equity. PI: Shikuma, C. Co-PI: Seto, T. Other: Gangcuangco, L. FundedbyNIH;$3,105,250awardedon 09/24/2022.Projectperiod:09/24/2022-06/30/2024.

27. Hawai’i Health Equity Research and Outreach Network (HAWAI’I HERON). Co-PI: Seto, T. FundedbyFDA;$549,514awardedon06/01/2023. Projectperiod:06/01/2023-05/31/2025.

28. Hawai`i State Department of Health Contract Award: HCV ECHO Learning Series - Evaluation. PI: Saltman, D. Providesoverallcoordinationfor accreditationandevaluationofHCVECHOHawaiiLearningSeries.Awarded$25,000.ProjectPeriod:05/15/2023toSeptember30,2023.

29. Hawaii Community Foundation Medical Research Grant. Co-PI: Brown, S. FundedbyHCF;$60,000awardedon06/20/2022.Projectperiod: 10/01/2022-03/30/2025.

30. Hawaii Pacific Islands Mammography Registry. Other: Seto, T. FundedbyNIH;$165,360awardedon04/01/2023.Projectperiod:04/01/202303/31/2028.

31 Hawaii to Zero. PI: Shikuma, C. FundedbyViivhealthcare;$94,954awardedon5/4/2023;projectperiod3/24/2023-11/30/2023

32. Impact of APOE and FOXO3 Genotype on Hemorrhagic Stroke in Japanese – American Men. PI: Nakagawa, K. FundedbyNIH;$255,000awarded on09/10/2019.Projectperiod:09/10/2019-08/31/2024.

33. Integrative Center for Precision Nutrition and Human Health. Other: Rettenmeier C, Stenger VA. PI:Berry.FundedbyNIH;$7,500,000awardedon 12/01/2021.Projectperiod:12/01/2021-11/30/2026.

34 John & Violet Kay Summer Research Fellowship. Other: Chow, D. FundedbyIolaniHighSchoolStudentSummerFellowshipprogram;$2,000 awardedon06/01/2021.Projectperiod:6/1/2021-8/21/2023.

35. L-type Calcium Channel SNPrs1006737: characterizing the genetic risks in Methamphetamine Use Disorder. Other: Stenger, V. FundedbyNIH; $150,000awardedon09/21/2023.Projectperiod:09/30/2023-09/29/2024.

36 Lesion Composition and Quantitative Imaging Analysis on Breast Cancer Diagnosis. Other: Seto, T. FundedbyNIH;$79,187awardedon8/9/2021 Projectperiod:08/09/2021-07/31/2026.

37. Longitudinal Study of Early NAFLD Progression and the Gut Microbiome in Asian Americans, Native Hawaiians and Whites. Other: Rettenmeier, C. FundedbyNIH;$3,342,000awardedon09/26/2022.Projectperiod:09/26/2022-06/30/2027.

38 Modeling SARS-CoV-2 fibrosis using a hACE2 mouse transgenic model. PI: Seidel Tallquist, M. FundedbyHCF Projectperiod:12/01/2006/30/24.

39. Modeling Tcf21-mediated epithelial to mesenchymal transition in cancer (subaward). PI: Seidel Tallquist, M. FundedbyHCF.Projectperiod: 06/01/23-05/31/24.

40. Movement Disorder Fellowship. Hawaii State Grant in Aid (OCS-GIA-23-48). Fellowship Director: Bruno, M. Projectperiod:05/23-04/25.

41. NCI Community Oncology Research Program. Co-PI: Acoba, J. FundedbyNIH;$6,574,755awardedon07/01/2018.Projectperiod:08/01/201907/31/2025.

42. Ola Hawaii Pilot Project Grant. Co-PI: Morgan, N. Intramurallyfunded;$50,000awardedon06/01/2023.Projectperiod:06/01/2023-05/31/2024.

43 Ola Hawaii Post Covid Pulmonary Long Covid Study. Other: Yess, J FundedbyNIH;awardedon09/01/2022 Projectperiod:09/01/202209/01/2024.

44. Open-Label, Single Center, Single Participant Study of An Experimental Antisense Oligonucleotide Treatment For ATN1 Mutation Associated Dentatorubral-Pallidoluysian Atrophy (DRPLA). PI: Liow, K. FundedbyN-Lorem;awardedin4/2024.

45. Pacific AIDS Education and Training Center (PAETC)-Hawaii and US-Affiliated Pacific Islands. Co-PI: Gangcuangco, L. FundedbyHRSA;$186,338 awardedon9/26/2023;projectperiod7/1/2023-6/30/2024.

46. PD GENEration Study, Parkinson's Foundation. Site PI: Bruno, M. Projectperiod:01/23-06/29.

47. Perceptions of Genomic Medicine and Technology among Native Hawaiian Patients Enrolled in a Longitudinal Healthcare Engagement Program. PI: Brown, S. Other: Yess, J. FundedbyHCF;$60,000awardedon6/20/2022.Projectperiod:10/01/2022-03/30/2024.

48. Perivascular adipose tissue in atherosclerosis. PI: Boisvert, W. FundedbyAHA;$10,000awardedon04/01/2024.Projectperiod:04/01/202403/31/2025.

49. Phase II study of TSR-022 in combination with TSR-042 for the treatment of advanced hepatocellular carcinoma. PI: Acoba, J. FundedbyGSK; $533,966awardedon04/09/2018.Projectperiod:04/09/2018-04/09/2025.

50 Radial Echo Volumar Imaging Grant. PI: Stenger, VA. Other: Rettenmeier, C. FundedbyNIH;$1,305,563awardedon7/9/2020 Projectperiod: 07/15/2020-03/31/2024.

51. Regulation of cardiac inflammation by fibroblasts. PI: Seidel Tallquist, M. FundedbyNCE.Projectperiod:07/01/2018-06/30/2024.

52. Role of Anti-Idiotype Autoantibodies (AA) Directed Against ACE2 in the Development of Pulmonary Post-Acute Sequelae of SARS-CoV2. PI: Shikuma, C. FundedbyLeahiFoundation(HCF)$60,000awardedon7/26/2023;projectperiod12/1/2022-6/1/2024

53. Ryan White Part B Care Act grants. PI: Chow, D. Co-PI: Gangcuangco, L. Other: Lu D, Shikuma C, Shiramizu, B. FundedbyHRSA;$300,000awarded on1/1/2021.Projectperiod1/1/2023-12/31/2023.

54. Telehealth Network Grant Program. PI: Koenig, M. FundedbyOAT;$1,200,000awardedon09/01/2020.Projectperiod:09/01/2020-08/31/2025.

55. The COVID-19 Neuro Databank-Biobank (The NeuroCOVID Project). Site PI: Liow, Kore; NYU PI: Andrea Troxel. FundedbytheNIHNational InstituteofNeurologicalDisordersandStroke,awarded9/2023.

56. The role of lung lipofibroblasts in alveolar differentiation. PI: Seidel Tallquist, M. FundedbyNCE.Projectperiod:2/1/2021-1/31/2024.

57. Training in Cardiovascular Research at the University of Hawaii. PI: Shohet, R. Other: Seidel Tallquist, M. FundedbyNIH;$400,000awardedon 08/01/2018 Projectperiod:08/01/2018-7/31/2024

58. Trial of Parkinson’s and Zolendronic Acid (TOPAZ) study. Parkinson’s Foundation. PI: Gao, F; Sub-I: Bruno, M. Projectperiod:05/21-06/26.

59. Ultrasound-directed gene therapy for Hemophilia B. PI: Shohet, R.FundedbyChunFoundation;$24,000awardedon06/01/2023.Projectperiod: 07/01/2023-06/30/2024.