PRAISE-U launches encouraging early detection of PCa

EU-wide project aims to reduce prostate cancer mortality through smart early detection

By Kevin McBride

The EU4Health programme has approved PRAISE-U (PRostate cancer Awareness and Initiative for Screening in the European Union), an ambitious three-year project involving 25 institutions from 12 countries. PRAISE-U’s mission is to design a nationally-tailored cost-effective early detection algorithm for prostate cancer screening in the EU to reduce morbidity and mortality caused by prostate cancer while avoiding overdiagnosis and overtreatment.

Prostate cancer is the number 1 and 2 cancer killing men in Northern and Western Europe respectively. It is the most frequent male cancer in Europe with important consequences for healthcare systems. Every year, around 450,000 European men are diagnosed with prostate cancer. Delayed diagnosis can lead to higher rates of metastasised disease, which is a disease state that coincides with a high mortality rate and a prolonged negative impact on the quality of life. It has been shown that organised repeated screening results in early detection that can reduce suffering and dying from prostate cancer.

[1] Modern tools and strategies can streamline the process to detect cancer when it poses a threat to the patient.

In direct partnership with a network of consortium members, PRAISE-U works to encourage early detection and diagnosis of prostate cancer in EU Member States through smart early detection and stimulate the implementation of early detection programmes in Member States. By aligning protocols and guidelines across Member States and enabling the collection and analysis of relevant data, the project aims to reduce prostate cancer morbidity and mortality rates in Europe with customised and risk-based screening programmes.

Prof. Hein Van Poppel, chair of the EAU Policy Office: “The diagnostic pathway for prostate cancer has improved tremendously over the past decades [2]. PRAISE-U marks a new era in early detection of prostate cancer. Through this project, we want to provide clear guidelines and quality assurance tools that can be used by pilot sites to demonstrate that risk based approaches are effective, feasible, acceptable and cost effective. In our consortium, we have a strong partnership with the right mix of international academic experts, healthcare professionals, social scientists, economists, patients and health system pilot sites to make this a success.”

European Association of Urology National Cancer Institute, Lithuania

Erasmus University Medical Center, Cancer Institute, Rotterdam Ghent University

European Randomized Study of Screening for Prostate Cancer Health Service Executive, Ireland

Estonian Urological Society

University Research Clinic for Cancer Screening, Randers Regional Hospital, Central Denmark Region

Institute of Health Information and Statistics of the Czech Republic University College Dublin, National University of Ireland, Dublin University Medical Center Utrecht World Organization of National Colleges, Academies and Academic Associations of General Practitioners/Family Physicians

European Cancer Organisation Movember Foundation

Lower Silesian Oncology, Pulmonology and Hematology Center

National Institute of Public Health, National Institute of HygieneNational Research Institute, Poland

To achieve PRAISE-U’s goals a multi-disciplinary consortium centred around Europe’s leading clinicians and researchers in prostate cancer has been established. The consortium includes experts in prostate cancer and decision making, and a network of hospitals, medical societies, patient advocates and national authorities.

Guenther Carl-Ernst, Chairman of Europa Uomo: “We are delighted to support the implementation of PRAISE-U and we are so glad prostate cancer

International Agency for Research on Cancer

European Society of Urogenital Radiology

Department of Health of Galicia, Consellería de Sanidade de Galicia Europa Uomo

Althaia Xarxa Assistencial Universitaria The Czech Urological Society

Region Västra Götaland Sweden Region Stockholm, Sweden

Region Skåne, Sweden

Table. 1 The participants of the PRAISE-U consortium is finally getting the attention it deserves as the EU’s most common male cancer. For us, every man whose cancer is detected too late, is one man too many.”

The PRAISE-U project is broken down into six work packages. The four core WPs are designed to gather knowledge, develop protocols for screening programs, pilot test the developed protocols, and evaluate the results. The two overarching WPs provide a framework for the entire project and include coordinating the project and disseminating the results. Each WP builds on the work of the previous one, and together they contribute to the ultimate goal of developing a strategy that will reduce prostate cancer morbidity and mortality while minimizing overdiagnosis.

On 25-26 April, more than 50 members of PRAISE-U participated in the kick-off event for a new Pan-European prostate cancer screening initiative in Brussels.

For more info please visit www.praise-u.eu/

References:

1. Hugosson, J., Roobol, M. J., Månsson, M., Tammela, T. L., Zappa, M., Nelen, V., ... & Auvinen, A. (2019). A 16-yr Follow-up of the European Randomized study of Screening for Prostate Cancer. European urology, 76(1), 43-51. https://doi.org/10.1016/j.eururo.2019.02.009.

2. Van Poppel, H., Albreht, T., Basu, P., Hogenhout, R., Collen, S., & Roobol, M. (2022). Serum PSA-based early detection of prostate cancer in Europe and globally: past, present and future. Nature reviews. Urology, 19(9), 562–572. https://doi.org/10.1038/s41585-022-00638-6

3. Van Poppel H. et al. Prostate-specific Antigen Testing as Part of a Risk-Adapted Ealy Detection Strategy for Prostate Cancer: European Association of Eurology Position and Recommendations for 2021. Eur Urol (2021), Https://doi.org/10.1016/j.eururo.2021.07.024.