Two New Research
Policies
Status of Dental
Research (FY2011) Spotlight on Dr.
Anastasios Karydis
SUPPORTING THE
Volume 1
Issue 4
Summer 2011
Dental Research OF DENTISTRY TODAY
MESSAGE from the SENIOR EXECUTIVE ASSOCIATE DEAN for RESEARCH
It is July in Memphis, which means that most Memphians are beginning to move a little slower and take things a little easier until the cool of fall arrives in late September. But it is quite the opposite in the College of Dentistry, where July signifies one of the busiest times in the College. Among many other things, matriculation has begun for the new academic year and the university is working to close out another fiscal year. Despite the glaring heat of summer, now is not the time to slow down.
With the close of FY2011, I am pleased to announce that this past year has shown to be the most productive research year in the College of Dentistry in over a decade. More faculty were engaged in research, with more grants submitted, leading to more grants awarded and more external funding. This, in turn, led to more publications than in previous years. This past year, nearly 30% of full- and part-time faculty members were involved in research, with 22% as investigators on funded research projects. There were a total of 31 active grants, on topics ranging from the effects of cranberry components on oral health to biocompability of restorative treatments to clinical assessments of whitening products to metabonomics studies to the effectiveness of teaching students to read radiographs.
Franklin Garcia-Godoy, D.D.S., M.S.
In addition, more students than ever before are participating in dental research – largely thanks to support from the UT Dental Alumni. This summer, we have 18 students working with faculty mentors on projects – up from 14 in the previous summer and the 12 students the summer prior to that. And, many of our post-doctoral students and residents have been fortunate to secure funding for their research projects this past year, both from the dental alumni and private foundations. As we get into the flurry of the year, it is important to carry this momentum forward and continue to grow in research. To assist in that task, the College will soon have a laboratory available within the dental building. The renovations on the Bioscience Research Center are underway and scheduled to be complete by September. Also, the Clinical Research Center is set to begin construction in early fall. Both of these new facilities will help to secure interest and funding from private sponsors. These facilities will also increase the amount of laboratory space available to faculty and students.
There are also many new faculty members on campus this summer. They bring with them unique experiences and ideas which can benefit the current projects on campus. And there are new grants beginning this July – two of which are new federal grants and one which is a new clinical product study. In other words, July is showing to be a great time to get involved in the new beginnings, and, as I stated above, it is not the time to slow down.
Dental Research edited by: Laurie (Wedel) Johnson, M.A.
Inside this Issue
RESEARCH FACULTY and STAFF
3
DENTAL RESEARCH NEWS
4
New Policies | Two Faculty Members Receive Federal Grants | Status of Dental Research
COLLEGE of DENTISTRY NEWS
7
QUARTERLY RESEARCH SPOTLIGHT
8
New Director of Imaging Sciences | Construction Update Dr. Anastasios Karydis, Assistant Professor, Department of Periodontology
CLINICAL RESEARCH
9
PUBLICATIONS and PRESENTATIONS
11
GRANTS and SPONSORSHIPS
12
Read this issue’s QUARTERLY RESEARCH SPOTLIGHT to learn about Dr. Anastasios Karydis, Assistant Professor in the Department of Periodontology, and his current dental research projects.
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Research Faculty and Staff SENIOR EXECUTIVE ASSOCIATE DEAN for RESEARCH Franklin Garcia-Godoy, D.D.S., M.S.
Chair, Department of Bioscience Research Director, Bioscience Research Center Professor, Department of Physiology, University of Tennessee Health Science Center Adjunct Professor, Department of Biomedical Engineering, University of Memphis Adjunct Professor, Department of Biomedical Engineering, Florida International University Senior Clinical Investigator, The Forsyth Institute, Boston, Massachusetts Adjunct Professor, Department of Conservative Dentistry and Periodontology, University of Munich
FACULTY Jegdish Babu, B.S., M.S., Ph.D. Associate Professor Melody Barron, D.D.S. Assistant Professor Director, TMD/Sleep Disorder Clinic Mustafa Dabbous, M.S., Ph.D. Professor Edward Harris, Ph.D. Professor Dr. Antheunis Versluis, Director of Biomaterials
Christopher Nosrat, D.D.S., Ph.D. Professor Mark Scarbecz, Ph.D. Professor Director of Planning and Assessment Edwin Thomas, M.S., Ph.D. Professor David Tipton, D.D.S., Ph.D. Professor Antheunis Versluis, Ph.D. Professor Director of Biomaterials
STAFF Brandy Clark, CDA, RDA Clinical Dental Assistant Kimberly DeMonaco, R.D.H. Clinical Research Associate Margaret Jefferson Sr. Research Assistant Laurel Johnson, B.A., M.A. Grants & Clinical Research Coordinator Geraldine Moore Lab Assistant Iva Pendleton Admin Service Assistant Michelle Sims, B.S. Research Coordinator Nancy Turner Administrative Aide Linda Vincent TMD/Sleep Disorder Clinic Coordinator
Front from left: Laurel Johnson, Dr. Zhang, Margaret Jefferson, Kimberly DeMonaco Back from left: Dr. Dabbous, Dr. Karydis, Dr. Thomas, Gerry Moore, Dr. Garcia-Godoy, Dr. Tipton
Yanhui Zhang, B.S., M.S., Ph.D. Research Associate 3
Dental Research News
TWO NEW POLICIES for FACULTY in DENTAL RESEARCH
This past May, Dr. Timothy Hottel, Dean of the College of Dentistry, and Dr. Franklin Garcia-Godoy, Senior Executive Associate Dean for Research, announced two new policies for faculty involved in dental research.
The first is a Grants/Contracts Pre-Submission Policy. Under this new policy, all faculty must route any grant or contract paperwork through dental research administration (i.e., Grants Coordinator, Senior Executive Associate Dean for Research) prior to submission to the UTHSC Office of Research Administration. Under current institutional policy, all grants and contracts must be approved and processed by the Office of Research Administration (ORA) before submission to any external agency. Completed paperwork must be received by ORA at least five working days prior to the official deadline of the agency. This new policy for dental research requires that all paperwork is first routed to dental research administration, at least two days prior to the ORA deadline (or, seven working days prior to the official agency deadline). The purpose of this new policy is to create a standardized system for submitting research grants and contracts, where all paperwork is routed to the same group, verified for accuracy, and sent out as a polished, complete package. This is most important for budgetary issues, as all budgets will be checked for completeness and compliance with institutional and agency standards. In addition, this new policy will help college administration better track the research activities of faculty members.
The second new policy concerns research activity reporting. All faculty members will be required to report all research-related activities to the Senior Executive Associate Dean for Research as soon as the activity is realized. Activities include, but are not limited to, journal articles, published abstracts, books or book chapters, presentations, keynote speeches, invited lectureships, grants (both submissions and awards), contracts, and awards or honors (as long as they relate to research). Activities can be sent via email to Dr. Franklin Garcia – Godoy at godoy@uthsc.edu.
The purpose of this new policy is to increase the efficiency and accuracy of research activity tracking and reporting. As the College of Dentistry and UTHSC as a whole focuses more heavily upon research, it is important to be able to provide accurate statistics on the research activities of faculty members, as well as students. Use of this information will also be warranted to secure external funding – of which many agencies require this type of information about the College.
Please contact Dr. Franklin Garcia-Godoy with any additional questions.
THREE NEW FEDERAL GRANTS AWARDED to COD FACULTY A special congratulations to three College of Dentistry faculty members who recently received Federal grant funding.
(1) Dr. Liang Hong, Professor and Director of Community Oral Health, is a co-principal investigator on an R44 (SBIR Phase II) titled, “Development of miniature plasma brush for dental clinical applications.” Dr. Hong will receive over $364,019 for his effort over a two year performance period, with the opportunity for continued funding for additional performance years. (2) Dr. Christopher Nosrat, Professor in Bioscience Research, is a co-investigator on an R01 with Dr. Lawrence Pfeffer (PI), Professor in the Department of Pathology, College of Medicine. This grant is for two years for a total of $1,075,000. (3) Dr. Franklin Garcia-Godoy, Senior Executive Associate Dean for Research, was awarded a continuation of the R13 for the Hinman Student Research Symposium 2011, for the amount of $20,000.
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STATUS of DENTAL RESEARCH at UTHSC – FY2011 It is hard not to notice that the dental research program at UTHSC is expanding. Over the last three fiscal years, more faculty members are participating in research activities – submitting more grants, publishing more articles, presenting at conferences, and mentoring student researchers. Part of the increase in dental research can be attributed to the change in administration and the new emphasis placed on having UTHSC College of Dentistry become a leader in dental research. This endeavor has been very successful.
Even in an economic recession, in FY2011, College of Dentistry faculty secured nearly $600,000 in new funding for research projects, coming in the form of fifteen new grants – two of which were federal, four were industrial, and six were from UT Dental Alumni – and three new donations to research projects. This is a 190% new funding increase from FY2010 and almost a 400% increase over FY2009. Of the funds that were awarded in FY2011, 31% were industrial, 26% federal, 25% donated funds, and 18% alumni grants.
Funds Awarded - FY2009 to FY2011
600000 500000 400000 300000 200000 100000 0
FY2009 FY2010 FY2011
The reason for the increase in funding is simple: more grants are being submitted. Between FY2009 and FY2010, the number of grants submitted and the number of grants awarded was relatively stable. However, between FY2010 and FY2011, the number of grants submitted nearly doubled, and so being, the number of grants awarded increased, inflating with it the amount of external funding.
Grant Activity - FY2009 to FY2011
Grants Submitted Grants Awarded
FY2011
Active Grants
FY2009
FY2010 0
10
20
30
With more active grants (funded research projects) than there have been over the last three years, other research-related activities are also increasing. The number of poster presentations and table clinics has increased, once again tripling and doubling from 5
those numbers reported for FY2009 and FY2010, respectively. The number of publications by UTHSC faculty (including journal articles, books, book chapters, and published abstracts) has slowly increased over the past three fiscal years, with FY2009 showing a marked increased over FY2008 (nearly 15% increase) and FY2010 and FY2011 having a few more publications than each year prior.
Publications & Presentations
100 90 80 70 60 50 40 30 20 10 0
FY2009
Publications
FY2010
Presentations
FY2011
When compared to previous years, the number of faculty members engaged in research has shown a large increase. And even though the number of faculty investigators on funded research projects has not grown very much, the diversity in department affiliations has definitely changed. In FY2011, at least one faculty member from each department was engaged in a funded research project – the first time in the last four years.
Distribution by Department
PROSTH 9%
PERIO 14%
PDCH 3% ORTHO OMS 3% 3%
REST 15%
BIDX 9%
BIOSCI 32%
ENDO 12%
Future plans for dental research at UTHSC include a continued emphasis on collaboration across departments, colleges, and institutions, and strong encouragement of faculty and students to seek funding for their research interests. As was demonstrated in FY2011, the more grants submitted, the more grants awarded. And, with fewer funds available, one of the best ways to navigate the competitive market is through collaboration and innovation. As the college continues to modernize, cutting-edge dental research will be a key structure in that modern foundation.
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College of Dentistry News
COLLEGE of DENTISTRY WELCOMES NEW DIRECTOR of IMAGING SCIENCES
The College of Dentistry recently welcomed Dr. Werner Shintaku, D.D.S., M.S., as an Associate Professor and Director of Imaging Sciences in the Department of Biologic and Diagnostic Sciences. Dr. Shintaku received his D.D.S. degree from the University of Sao Paulo, Brazil, where he also received his Oral and Maxillofacial Radiology certificate and Masters degree. In 2009, he received a speciality degree in Oral Diagnosis from the Brazilian Dental Board.
Dr. Shintaku was the Director of Oral and Maxillofacial Radiology at the University of Southern California before entering into a three-year program at the University of Texas Health Science Center at San Antonio. At UTHSC-San Antonio, Dr. Shintaku earned a certificate and M.S. in Oral and Maxillofacial Radiology in 2010. He was recently named a diplomate of the American Board of Oral and Maxillofacial Radiology and joined the UT faculty in 2011.
Dr. Shintaku has started working to identify research and clinical goals for Oral and Maxillofacial Radiology (OMR). He is working to become involved in current research projects that involve OMR and collaborate on new projects. In addition, he has started to restructure didactic material and clinical activities.
CONSTRUCTION BEGINS on the FIFTH FLOOR CLINICS and BIOSCIENCE RESEARCH CENTER Construction is now underway on the 5th floor dental clinics. Beginning in June, all of the old dental units, flooring, and esthetics have been removed to make way for new construction. The current project has an anticipated completion of early fall, after which time construction will move to the 3rd floor.
In addition, construction finally began on the Bioscience Research Center on the administrative floor of the dental building. This will be the first dental laboratory on-site at the dental building and will contain five different cores: (1) demineralization/remineralizatio pH cycling; (2) biofilm (plaque) regrowth analysis; (3) biofilm metabolomics*; (4) bacterial DNA virulence analysis, and; (5) dental erosion. The Bioscience Research Center has an anticipated completion date of early September. Fifth floor dental clinics July 6, 2011
The dental administrative offices are also progressing. Demolition started in December 2010. At present, university employees are finishing electrical and duct work in the suite and should begin esthetic work shortly. These offices are projected to be completed by fall of this year.
Once again, the College thanks everyone for minding the dust and noise of the construction as we work to improve the facilities for our students, staff, and faculty.
*Metabolomics is the scientific study of chemical processes involving metabolites. Specifically, metabonomics is the “systematic study of the unique chemicl fingerprints that specific cellular processes leave behind,� the stuy of their small-molecule metabolite profiles. 7
Bioscience Research Center June 30, 2011
Research Spotlight
SPOTLIGHT on DR. ANASTASIOS KARYDIS:
HARD TISSUE BIOLOGY and MINERALIZATION in DENTAL RESEARCH
Dr. Anastasios Karydis has been an Assistant Professor in the Department of Periodontology at the University of Tennessee since 2008. Throughout his career in dentistry, he has been involved in research on hard tissue biology and mineralization studies. Below is a spotlight on his current research projects with dental and medical faculty as well as dental students at UTHSC.
TOOTH MINERALIZATION
Summer Research Project: Alexander Garcia-Godoy (D-3), Dr. Anastasios Karydis, Dr. Aline Martin (Nephrology), Dr. Val David (Nephrology), Dr. Franklin Garcia-Godoy (Bioscience Research), Dr. Darryl Quarles (Nephrology)
Background Dental mineralized tissues closely resemble bone in composition and mechanism of formation, but the mechanisms for tooth mineralization remain largely unclear. Dentin Matrix Protein-1 (DMP-1) is a non-collagenous dentin matrix protein with an important role in dental tissue and bone mineralization, while PHEX is endopeptidase, most likely responsible for regulation and cleavage of DMP1. Inactivating mutations in knockout mice not expressing PHEX or DMP1 available in the laboratory of Dr. Quarles are presenting with comparable phenotypes of bone mineralization defects, Rickets-like disease, osteomalacia, and hypophosphatemia. In humans, the X-linked hypophosphatemia (XLH) and its murine homologue, Hyp, are caused by inactivating mutations in PHEX gene. Moreover, mice that are null for DMP1 develop a bone phenotype characterized by hypomineralization, short and wide vertebrae, long bones with delayed and malformed secondary ossification centers, and abnormal osteocyte morphology associated with loss of dendritic extensions. In teeth, DMP1 is crucial for mineralization and maturation of predentin into dentin during later stages of dentinogenesis, and PHEX is highly expressed in teeth with bone and cartilage, but limited information is known about the role of PHEX on tooth development and mineralization and the role of both DMP1 and PHEX on enamel mineralization
Research The mandibles and teeth of Hyp mice are compared with wild type and Dmp-1 -/- mice and are analyzed by high resolution micro-CT and histology to evaluate the alveolar bone and the tooth microarchitecture. This study provides a model to study tooth mineralization in genetic disorders with mouse models and can provide a better understanding of tooth and bone mineralization defects in patients with hypophosphatemia, phosphaturia, and osteomalacia.
BONE BIOLOGY
NIH Grant Application: Dr. Darryl Quarles (Nephrology), Dr. Zhousheng Xiao (Nephrology), Dr. Aline Martin (Nephrology), Val David (Nephrology), Bing Dai (Nephrology), Dr. Anastasios Karydis Background While our skeleton is largely recognized for its mechanical role that protects internal organs, supports and facilitates movement and its synthetic role for 8
Figure 1. Hyp mice display growth retardation, reduced body weight and length, and skeletal dysplasia/skeletal defects consistent with Rickets/osteomalacia, when compared with wild type mice, and serve as a model to study rare genetic diseases otherwise difficult to study due to the low occurrence and limited dental access to such patients.
blood production, its metabolic role is commonly overlooked. Bones act as reservoirs for growth factors and minerals and also as endocrine organs controlling phosphate metabolism via the secretion of fibroblast growth factors-23 (FGF23), a circulating factor produced predominantly by osteoblasts and osteocytes that regulate vitamin D metabolism and act on kidneys to reproduce phosphate reabsorption. The study of FGF23 in Dr. Darryl Quarles’s lab focus on both the local bone-derived and systemic factors responsible for the physiologic control and regulation of FGF23. Research Our purpose is to study the physiological function of FGF23 that coordinates the mineralization of extracellular matrix with the renal handling of phosphate and the fibroblast growth factor receptor (FGFR) signaling pathway underlying the local intrinsic and systemic factors that control FGF23 gene transcription and promoter regulation and the integrative physiology of bone remineralization, FGF23, PTH, and vitamin D metabolism. These pathways are studied in both mouse models, including wild type, PHEX-deficient Hyp, FGF23 null and DMP1 null mice, as well as in osteoblasts derived from these mice.
BONE PATHOBIOLOGY
Presentation at the IADR/AADR 2011 Meeting in San Diego: Dr. Anastasios Karydis, Dr. David Tipton (Bioscience Research), Dr. Franklin Garcia-Godoy (Bioscience Research) Background Nitrogenous Bisphosphonates (BPs) are used widely in the management of patients with diseases characterized by abnormal bone metabolism and excessive bone resorption, including multiple myeloma, bone mestatasis from breast, lung, or prostate cancer, and osteoporosis. Long-term BP administration has been associated with osteonecrosis of the jaw (bisphosphonate associated osteonecrosis – BON), defined as non-healing, exposed necrotic bone in the maxillofacial region, often accompanied by infection, pain, purulence, osteolysis, and jaw fracture. Manifestation of BON adversely affects the quality of life and is causing significant morbidity in the afflicted patients. Currently, there is no consensus for the management of the lesions and there is only partial understanding of the mechanism of onset of BON. This is due to the lack of both basic research that will clarify the effect of BPs on the soft and hard oral tissues and clinical studies regarding the efficacy of management protocols. In addition, the long lasting effect of BPs on osteoclasts and osteoblasts has been established, but both the role of BPs on oral fibroblasts and epithelial cells, and its significance for the pathogensis of BON remain largely unknown. At the College of Dentistry Bioscience Research Center, we investigate in vitro the effect that BPs on oral fibroblasts and epithelial cells and their cellular functions as a possible mechanism for BON. Research BPs impair the actin-rich filopodia and inhibit focal contacts and cell adhesion of oral fibroblasts and epithelial cells. The inhibitory effect of BPs on soft tissue cells may contribute to the characteristic impaired healing of BON as an additional mechanism in the pathogenesis of BON. This project can contribute to the understanding of a novel mechanism for the impaired healing of BON lesions in the cellular level. Data generated from this project will indicate whether oral soft tissue cells are affected by BP treatment and may direct future research to include the study of oral soft tissues for prevention and management of BON.
Figure 2. Paxillin (focal adhesion protein) immunostaining shows that focal adhesion abundance and consecutively cell adhesion is impaired in gingival fibroblasts treated with alendronate (treatment with 100 μM alendronate, 63x; blue: nuclei, green: paxillin).
For more information or any questions regarding these research projects, please contact Dr. Anastasios Karydis at akardyis@uthsc.edu, Department of Periodontology, UTHSC College of Dentistry. 9
Clinical Research
The following is a list of current clinical research studies being conducted by UT College of Dentistry faculty. The title, investigators, and study objective are listed for each project.
A comparison of the effects of occlusal adjustment and splint therapy on symptoms reduction in TMD Study Objective: The purpose of this study is to compare the effectiveness of occlusal adjustment and splint therapy on the therapeutic management of temporomandibular dysfunction (TMD). Principal Investigator:
Dr. Swati Ahuja
Co-Investigators:
Dr. David Cagna Dr. William McHorris
A study to assess the effects on plaque glycolysis, metabolites, and composition of an experimental dentifrice compared to two marketed dentifrices. Study Objective:
A methods development study to evaluate the impact of an experimental dentifrice on the antiglycolytic activity of dentinal plaque bacteria relative to two marketed dentifrices.
Principal Investigator:
Dr. Franklin Garcia-Godoy
Co-Investigators:
Dr. Laura Darnell Dr. Anastasios Karydis Dr. Lew Powell
Research Staff:
Kimberly DeMonaco, R.D.H. (Clinical Research Associate) Laurie Johnson, M.A. (Study Manager) Nancy Wilson (Assistant Coordinator) Yanhui Zhang, Ph.D. (Research Associate)
CS 9300 Extraoral Imaging System Evaluation Study Objective:
To evaluate the quality of the images of the x-rays of the new investigational system (CS 9300) compared to the 9500
Principal Investigator:
Dr. Lawrence Weeda
Participating Dentists:
Dr. Melody Barron Dr. Jeffrey Brooks
Effects of Non-Thermal Plasma Treatment on Composite Restoration and Caries Prevention Study Objective:
To test the ability of a new miniature plasma brush to be used in dental clinical applications to prevent tooth decay and improve the quality of dental restorations.
Co-Principal Investigator: Dr. Liang Hong Co-Investigator:
Dr. Zhousheng Xiao (Nephrology)
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Influence of maternal factors on caries development during early childhood (Ancillary Study to the CANDLE Study) Study Objective:
The purpose of this study is to investigate the impact of maternal factors on the development of dental cavities among 3 years old children.
Principal Investigators:
Dr. Franklin Garcia-Godoy Dr. Liang Hong
Co-Investigators:
Dr. Fran Tylavsky (Preventive Medicine) Dr. Martha Wells Dr. Elizabeth F. Webb (Pediatric Resident)
Research Staff:
Kimberly DeMonaco, R.D.H. (Clinical Research Associate) Laurie Johnson, M.A. (Study Manager) Colette Stewart, R.D.H., B.S., M.S.O.L. (Research Associate)
Oral Streptococus species in pre-term and full-term 24-36 month old African-American children in Memphis, Tennessee – A crosssectional study Study Objective:
The study objective is to investigate five Streptococcus species commonly found in the oral biofilm of children to determine their relative numbers in 24-36 month old healthy African-American pre-term and full-term children residing in Memphis, Tennessee.
Principal Investigators:
Dr. Renalie Rebong (Pediatric Resident) Dr. Emily Fourmy (Pediatric Resident)
Co-Investigators:
Dr. Franklin Garcia-Godoy Dr. Jegdish Babu
Consultant:
Dr. Reddy Dhanireddy (Department of Pediatrics)
Research Staff:
Laurie Johnson (Study Manager) Dr. Yanhui Zhang (Research Associate)
UPCOMING GRANT DEADLINES
FALL STANDARD DUE DATES (NIH)
P series (all): Due to Office of Research Administration (ORA): Due to Dental Research Administration:
September 25 September 19 September 15
K series (new): Due to Office of Research Administration (ORA): Due to Dental Research Administration:
October 12 October 5 October 3
R15 (new): Due to Office of Research Administration (ORA): Due to Dental Research Administration:
October 25 October 18 October 14
R01| U01| UM1 (new): Due to Office of Research Administration (ORA): Due to Dental Research Administration:
R03 | R21 | R33 | R34 | R36 (new): Due to Office of Research Administration (ORA): Due to Dental Research Administration:
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October 5 September 28 September 26
October 16 October 10 October 6
Publications Presentations
The following is a list of publications by College of Dentistry faculty from April 2011 to present, and recent as well as upcoming presentations.
PUBLICATIONS
Ahuja SA, Cagna DR. Classification and management of restorative space in edentulous implant overdenture patients. J Prosthet Dent. 2011;105:332-337.
Cardenas L, Garcia-Godoy F, Splieth CH. Pulpectomy. In: Splieth CH, Revolutions in Pediatric Dentistry. Chapter 15, Quintessence Publishing Company. Berlin. 2011.
Pecie R, Krejci I, Garcia-Godoy F, Bortolotto T. Noncarious cervical lesions (NCCL). Part 1. Prevention. Am J Dent. 2011;24:49-56.
Pecie R, Krejci I, Garcia-Godoy F, Bortolotto T. Noncarious cervical lesions (NCCL). Part 2. Restoration. Am J Dent. 2011;24:183192. Hosoya Y, Shiraizi T, Odatsu T, Miyazaki M, Garcia-Godoy F. Effects of polishing on surface roughness, gloss and color of surface reaction type pre-reacted glass-ionomer filled resin composite. Am J Dent. 2011;24:138-142. Ayad MF, Maghrabi AA, Saif RR, Garcia-Godoy F. Influence of tooth preparation burs on the roughness and bond strength of adhesives to human dentin surfaces. Am J Dent. 2011;24:176-182.
Antonelli J, Hottel TL, Siegel SC, Darnell LA. The acrylic resin transfer coping technique for making accurate interocclusal records. J Tenn Dent Assoc. 2011;91:17-23.
Martin A, Liu S, David V, Li H, Karydis A, Feng JQ, Quarles LD. Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor (FGFR) signaling. FASEB J. 2011 Apr 20. [Epub ahead of print]. Rosebush M, Rao SK, Samant S, Gu W, Handorf C, Pfeffer LM, Nosrat CA. Oral Cancer: Enduring characteristics and emerging trends. J Tenn Dent Assoc. 2011;91:24-29.
Tantbirojn D, Pintado MR, Versluis A, Dunn C, DeLong R. Quantitative analysis of tooth surface loss associated with gastroesophageal reflux disease – A longitudinal study. J Am Den Assoc [May 2011, accepted for publication].
Tantbirojn D, Chongvisal S, Augustson DG, Versluis A. Hardness and postgel shrinkage of preheated composites. Quintessence Int. 2011 Mar;42(3):e51-9. Versluis A, Versluis-Tantbirojn D. Filling cavities or restoring teeth? J Tenn Dent Assoc. 2011;91:36-42.
Baek SH, Lee CJ, Versluis A, Kim BM, Lee WC, Kim HC. Comparison of torsional stiffness of nickel-titanium rotary files with different geometric characteristics. J Endod [May 2011, accepted for publication]. Hur B, Kim HC, Park JK, Versluis A. Characteristics of non-carious cervical lesions – an ex vivo study using micro computer tomography. J Oral Rehabil. 2011;38:469-474
PRESENTATIONS
Dr. Franklin Garcia-Godoy, Senior Executive Associate Dean for Research, recently gave a Presentation at the Top-to-Top Lecture Series held in Santo Domingo, Dominican Republic on June 29th. Dr. Garcia-Godoy lectured on “Stem Cells in Dentistry.” 12
Grants Sponsorships
The following is a list of current grants/sponsorships held by UT College of Dentistry faculty.
FEDERAL/FOUNDATION GRANTS •
•
•
•
•
Influence of cranberry juice components on denture related stomatitis and Inflammatory reactions of gingival fibroblasts o PI: Jegdish Babu, B.S., M.S., Ph.D. (Bioscience Research) o Co-PI: David Tipton, D.D.S., Ph.D. (Bioscience Research) o Cranberry Institute of Wisconsin (Private Grant) o $40,200
Biocompatibility screening of restorative treatments o PI: Franklin Garcia-Godoy, D.D.S., M.S. (Sr Exec Assoc Dean for Research/Bioscience Research) o NIH High Priority, Short-Term Project Award (R56) o Amount: $135,000
Hinman Student Research Symposium o PI: Franklin Garcia-Godoy, D.D.S., M.S. (Sr. Exec Assoc Dean for Research/Bioscience Research) o NIH/NIDCR (R13) o Amount: $20,000
Development of miniature plasma brush for dental clinical applications o Co-I: Liang Hong, D.D.S., M.S., Ph.D. (PDCH/Director of Community Oral Health) o NIH/NIDCR (R44 SBIR Phase II) o $364,019
Novel Methods in Brain Tumor Research o Co-I: Christopher Nosrat, D.D.S., Ph.D. (Bioscience Research) o NIH (R01) o $1,075,000
SPONSORSHIPS •
•
•
A study to assess the effects on plaque glycolysis, metabolites, and composition of an experimental dentifrice compared to two marketed dentifrices. o PI: Franklin Garcia-Godoy, D.D.S., M.S. (Bioscience Research) o Private per terms of contract Evaluation of the CS-9300 o PI: Lawrence Weeda, D.D.S. (Oral & Maxillofacial Surgery) o Carestream Dental
Visualization of sealer movement during single-cone obturation with EndoSequence BC Sealer o PI: Adam Lloyd, B.D.S., M.S. (Endodontics) o Real World Endodontics/Brasseler USA
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ABOUT the COLLEGE of DENTISTRY The UTHSC College of Dentistry was founded in 1878 making it the oldest dental college in the South, and the third oldest public college of dentistry in the United States.
The College contains a 4-year dental program, totaling approximately 320 students. In addition, students in the Postgraduate dental programs and Dental Hygiene are included.
The College is dedicated to providing professional, graduate, and postgraduate education; conducting dental research; and, delivering state-of-the-art patient care and public service.
College of Dentistry 875 Union Avenue Memphis, TN 38163 Phone: (901) 448-6200 Fax: (901) 448-1625
FOR MORE INFORMATION ABOUT THE UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER, VISIT: www.uthsc.edu
The University of Tennessee is an EEO/AA/Title VI/Title IX/Section 504/ADA/ADEA institution in the provision of its education and employment programs and services.
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