DENTAL RESEARCH Handbook
UNIVERSITY OF TENNESSEE
College of Dentistry
THE UNIVERSITY of TENNESSEE HEALTH SCIENCE CENTER
Page
2
COLLEGE of DENTISTRY
TABLEContents OF PREFACE
4
INTRODUCTION
5
DEPARMENT CONTACTS
6
Franklin Garcia-Godoy, D.D.S., M.S. Senior Executive Associate Dean for Research
CENTERS FOR DENTAL RESEARCH DENTAL RESEARCH AT UTHSC • •
Biomaterials Research Craniofacial Research
SECTION I: FACULTY IN RESEARCH
A) Department of Bioscience Research o Bioscience Research Staff B) Funded Research Faculty o Federal, Industrial, or Foundational Grants o Dental Alumni Research Grants
SECTION II: STUDENTS IN RESEARCH • •
• •
For Students Interested in Research Student Research Training Program - Details of the Program - Selecting a Research Mentor - 2010 Student Summer Research Mentors - Steps to Follow Student Research Day Hinman Student Research Symposium
7 8 8 9
11 12 23 24 25 29 37 39 41 42 43 44 48 49 50
3
•
Timothy L. Hottel, D.D.S., M.S., M.B.A. Dean, College of Dentistry
Page
•
PREFACE Dean Hottel Increased emphasis has been placed on research in the College of Dentistry. Although our primary mission is to train successful general dentists, dental research is an important part of the educational process.
With the successful hiring of several research-oriented faculty, the University of Tennessee College of Dentistry has appeared in publications ranging from the Dental Products Reports to texts like “Cancer Metastasis – Biology and Treatment.” We are poised to become a leader in dental research with new industry support and multiple new research grants, covering areas from sealants to stem cells. For this, I would like to thank those who have supported faculty and student research efforts to advance the dental profession – with a special thanks to our alumni.
Timothy L. Hottel, D.D.S., M.S., M.B.A.
Page
4
Dean, College of Dentistry
INTRODUCTION Senior Executive Associate Dean for Research The purpose of this compendium of current research efforts in the College of Dentistry at the University of Tennessee Health Science Center is to facilitate communication and collaboration in research among faculty; to assist students in selecting areas of research and mentors for their student research projects; and, to inform the alumni and other health professionals in the Mid-South and the dental industry of the expertise and assistance that is available to prospective researchers in the UT College of Dentistry.
Franklin Garcia-Godoy, D.D.S., M.S.
Page
5
Senior Executive Associate Dean for Research Chair, Department of Bioscience Research Director, Bioscience Research Center Professor, Department of Physiology
DEPARTMENT Contacts ADMINISTRATION
ASSOCIATE DEANS Academic and Institutional Affairs Mark R. Patters, D.D.S., Ph.D.
Admissions & Student Affairs (Interim Associate Dean) John S. Covington, III, D.D.S., M.S., F.R.S.M.
Clinical Affairs Lloyd A. George, D.D.S., M.Ed., J.D.
Research Franklin Garcia-Godoy, D.D.S., M.S.
(901) 448-6200 (901) 448-7886 (901) 448-6268 (901) 448-6413
DEPARTMENT CHAIRS
(901) 448-6333
BIOLOGIC & DIAGNOSTIC SCIENCES John S. Covington, D.D.S. M.S. F.R.S.M.
(901) 448-8609
BIOSCIENCE RESEARCH Franklin Garcia-Godoy, D.D.S., M.S.
ENDODONTICS Peter DiFiore, D.D.S., M.S. (Interim Chair)
ORAL & MAXILLOFACIAL SURGERY Lawrence W. Weeda, Jr., D.D.S.
ORTHODONTICS Terry M. Trojan, D.D.S., M.S. (Interim Chair)
PEDIATRIC DENTISTRY & COMMUNITY ORAL HEALTH Bill W McCann, D.D.S., M.S. (Interim Chair)
PERIODONTOLOGY Paul S. Bland, D.D.S.
PROSTHODONTICS Russell A. Wicks, D.D.S. RESTORATIVE Janet Harrison, D.D.S.
(901) 448-6333 (901) 448-6618 (901) 448-6236 (901) 448-6214 (901) 448-6206 (901) 448-6242 (901) 448-6380 (901) 448-6692
6
Timothy L.Hottel, D.D.S., M.S., M.B.A.
Page
DEAN
CENTERS FOR Dental Research
Dental research is being conducted at a variety of laboratories and clinics across the University of Tennessee Health Science Center campus, as well as at regional medical and public health centers in Tennessee and Arkansas. However, the designated campus dental research centers are listed below.
BIOMATERIALS RESEARCH CENTER 138 Nash Research Building 894 Union Avenue
BIOSCIENCE RESEARCH CENTER N102 Dunn Dental Building 875 Union Avenue
CANCER RESEARCH CENTER
119 Cancer Research Building 19 S. Manassas Street
CLINICAL RESEARCH CENTER
Dunn Dental Building, 3rd Floor 875 Union Avenue
CRANIOFACIAL RESEARCH CENTER 429/B12 Boling Center 711 Jefferson Avenue
TMD/SLEEP DISORDER CLINIC
Page
7
Dunn Dental Building, 3rd Floor 875 Union Avenue
DENTAL RESEARCH at UTHSC
Listed below is a summary of the different types of research currently being conducted by faculty in the COLLEGE of DENTISTRY at THE UNIVERSITY of TENNESSEE HEALTH SCIENCE CENTER. This list is not exhaustive.
BIOMATERIALS RESEARCH
Page
Clinical Testing • Whitening kits • Restorative materials • Endodontic materials • Periodontal therapies • Prosthodontic devices • Toothpaste • Mouthwash • Adhesives • Disinfectants • Analgesics • Drugs • Lasers • Dental instruments and devices • Toothbrushes (manual or power) • Ortho appliances/devices • Dental floss • Implants • Plaque and gingivitis
8
Biomaterials Development • Microtensile fracture strength testing • Profilometer fracture mode testing • Fatigue, thermocycling and load testing • Scanning electron microscope evaluation • Confocal electron microscope evaluation • Leakage testing • Hybrid layer evaluation • Remineralization and demineralization studies • Color and gloss analysis • Implant coatings
Toothbrushing • Dentifrice testing • Abrasion testing • Wear testing • Clinical testing • Biofilm
Biocompatibility Testing • Drugs and biomaterials • In vitro cytotoxicity • In vivo biocompatibility • Histological assessment • Genotoxicity assessment
Molecular Assays • Protein/Gene activation • PCR • Gene silencing • Gene isolation • Molecular pathway elucidation • Stem cells
CRANIOFACIAL RESEARCH
Page
Innate Immunity • Role of peroxidase enzymes of leukocytes and saliva in producing antimicrobial oxidizing agents that protect tissues against microbial infection and inflammation • Antibiotic peptides produced by human leukocytes, oral epithelial cells, and the salivary glands. Mechanisms of antimicrobial activity and the molecular basis for microbial resistance
9
Inflammation Research • Tissue alterations in periodontal diseases • Cellular response to anti-inflammatory drugs (i.e., COX inhibitors, transcription factor inhibitors), natural products (i.e., myrrh oil, tea tree oil, cranberry components), and oral rinses • Levels of arachidonic acid metabolites in gingival crevicular fluid in gingivitis/periodontitis • Role of fibroblast production of matrix metalloproteinases and inflammatory mediators in periodontal diseases and inflammatory TMJ destruction • Effects of methamphetamine on gingival fibroblasts and neutrophils in periodontitis
Oral Cancer • Analysis of tumor cell invasion and metastatic potential • Testing therapeutic potential of anti-tumor agents • Immunolocalization of specific tumor antigens in cells and tissue
Proteomic Analysis and Protein Expression Patterns • Proteomic analysis of cells and tissues • Tumor marker identification, characterization, and prognostic value
Bone Metabolism • Effects of drugs (i.e., bisphosphonates and statins) and natural products (i.e., cranberry components) on soft tissue cell (gingival fibroblast and epithelial cell) production of mediators of bone metabolism (i.e., IL-6, RANKL, OPG) Gingival Fibroses • Gingival fibroblast production/regulation of extracellular matrix molecules and matrix metalloproteinases in gingival fibroses (hereditary/idiopathic, druginduced) Molecular Assays • PCR • Bacterial gene isolation and gene product identification • Protein expression from isolated gene • DNA analysis
Clinical Testing • Assay for efficacy of mouthwash and toothpaste, using in vitro analysis • Evaluation of periodontal therapy products • Effects of natural products such as cannabidiol • Testing for biofilm in dental waterline (screening and enumeration of microbial populations in dental waterlines; culturing anaerobic bacteria)
Page
Craniofacial Pain • Therapy and treatment of neck and facial pain that is associated with temporomandibular joint disorders (TMD) • Treatment of sleep apnea and other sleep disordered breathing conditions through development and use of oral appliances
10
Biomaterials Testing • Cellular and tissue response to implant materials and other biomaterials • Cytotoxicity of implant and other biomaterials • Genotoxicity testing • Biofilm formation
Page
11
SECTION I: Faculty in Research
PART A: Department of Bioscience Research
Page
12
The Department of Bioscience Research houses the College of Dentistry’s Research Faculty, or faculty whose majority effort is dedicated to conducting dental research.
JEGDISH P. BABU, M.SC., M.S., PH.D. Associate Professor, Department of Bioscience Research Education: Ph.D., 1981, Michigan State University M.S., 1974, West Virginia University M.Sc., 1971, Osmania University, India Office Phone: (901) 448-4342 Email: jbabu@uthsc.edu
Research Interests: • Bacterial pathogenesis • Biofilm • Genomics of oral pathogens • Monocyte interactions with LPS of periodontal pathogens
Research Funding: • Private Industry • University of Tennessee College of Dentistry Alumni Endowment Fund
Page
13
Selected Publications: • Babu JP, Ofek I. Cranberry high molecular weight constituent affect selectively metabolic activity of Streptococcus sanguis in biofilm. Microbios. 2010 (accepted for publication). • Babu JP, Saha BK. Identification and characterization of Fusobacterium nucleatum surface components that mediate its interaction with salivary molecules. FEMS Microb Lett. 1997;117:32-38. • Babu JP, Dean JW, Pabst MJ. Attachment of Fusobacterium nucleatum to fibronectin immobilized on a solid phase. J Periodontal. 1995;666:285-290. • Babu JP, Dabbous MKh, Abraham SN. Isolation and characterization of a 180-kiloDalton salivary glycoprotein which mediates the attachment of Actinomyces naeslundii to human buccal epithelial cells. J Periodontal Res. 1991 Mar;26(2):97-106 • Babu JP, Abraham SN, Dabbous MKh, Beachey EH. Interaction of a 60-kiloDalton Dmannose-containing salivary glycoprotein with type 1 fimbriae of Escherichia coli. Infect Immun. 1986 Oct;54(1):104-108. • Babu JP, Beachey EH, Hasty DL, Simpson WA. Isolation and characterization of a 60kilodalton salivary glycoprotein with agglutinating activity against strains of Streptococcus mutans. Infect Immun. 1986 Aug;51:405-413. • Babu JP, Simpson WA, Courtney HS, Beachey EH. Interaction of human plasma fibronectin with cariogenic and non-cariogenic oral streptococci. Infect Immun. 1983;41:162-167.
MELODY BARRON, D.D.S. Assistant Professor, Department of Bioscience Research Director, TMD/Sleep Disorder Clinic Diplomate, Academy of Clinical Sleep Disorders Dentistry Fellow, Academy of Craniofacial Pain Education: D.D.S., 1992, University of Tennessee College of Dentistry B.S., 1982, University of Arkansas Office Phone: (901)448-1285 Email: mbarron6@uthsc.edu
Research Interests: • Craniofacial pain • Temporomandibular joint dysfunction (TMD) therapy and treatment • Sleep disorders (sleep disordered breathing and obstructive sleep apnea) and their relationships to craniofacial pain Research Funding: • None at present
Page
14
Selected Publications: N/A
JOEL D. BUMGARDNER, PH.D. Adjunct Professor, Department of Bioscience Research Associate Professor, Joint Biomedical Engineering Program (UTHSC and University of Memphis) Education: Fullbright Fellowship, 1993-1994, Umeå University, Umeå, Sweden Ph.D., 1988, University of Alabama at Birmingham M.S., 1988, University of Alabama at Birmingham B.S., 1988, University of Alabama at Birmingham B.S., 1984, Florida State University Office Phone: (901) 678-5243 Email: jbmgrdnr@memphis.edu / jbumgard@uthsc.edu
Research Interests: • Bone tissue engineering/Guided bone regeneration • Biomaterials development; corrosion/degradation of biomaterials. • Drug delivery • Dental implants and restorative alloys • Cell biomechanics
Page
Selected Publications: • Chesnutt BM, Viano AM, Yuan Y, Yang Y, Guda T, Appleford MR, Ong JL, Haggard WO, Bumgardner JD. Design and characterization of a noval chitosan/nanocrystalline calcium phosphate composite scaffold for bone regeneration. J Biomed Mat Res. 2009;88A(2):491502 • Norowski PA, Bumgardner JD. Biomaterial and antibiotic strategies for perio-implantitis: A review. J Biomed Mat Res. 2009;88B(2):530-543 • Bumgardner JD, Chesnutt BM, Yuan Y, Yang Y, Appleford M, Oh S, McLaughlin R, Elder S, Ong JL. The integration of chitosan-coated titanium in bone: An in vivo study in rabbits. Implant Dent. 2007;16(1):66-79 • Martin HJ, Schultz KH, Bumgardner JD, Walters KB. XPS study on the use of 3Aminopropyltriethoxysilane to bond chitosan to a titanium surface. Lanmuir. 2007;23(12):6645-6651 • Lin HY, Bumgardner JD. Changes in the surface oxide composition of Co-Cr-Mo implant alloy by macrophage cells and their released reactive chemical species. Biomat. 2004;25(78):1233-1238 • Bumgardner JD, Wiser R, Gerard PD, Bergin P, Chestnutt B, Marini M, Ramsey V, Elder SH, Gilbert JA. Chitosan: Potential use as a bioactive coating for orthopaedic and craniofacial/dental implants. J Biomat Sci. 2003;14(5):423-4238 • Roach MD, Wolan JT, Parsell DE, Bumgardner JD. Use of x-ray photoelectron spectroscopy and cyclic polarization to evaluate the corrosion behavior of six nickel-chromium alloys before and after porcelain-fused-to-metal firing. J Prosth Dent. 2000;84(6):623-634
15
Research Funding: • National Institutes of Health • National Science Foundation • Private Industry and Research Foundations
MUSTAFA KH.DABBOUS, PH.D. Professor, Department of Bioscience Research Professor, Department of Microbiology and Immunology, College of Medicine Professor (Hon.), College of Medicine, University of Tanta, Egypt Education: Ph.D., 1967, University of Tennessee Medical Units, Memphis, TN M.Sc., 1965, Massachusetts Institute of Technology (MIT) Office Phone: (901) 448-6167 Email: mdabbous@uthsc.edu
Research Interests: • Connective tissue alterations in periodontal disease (the matrix collagens and matrix metalloproteinases) • Tumor invasion and metastasis; the role of matrix metalloproteinases in metastatic spread • Tumor-specific cytokines in cell motility and their correlation with metastatic potential • Tumor markers and metastatic potential of tumor cells
Page
Selected Publications: • Dabbous MKh, Jefferson MM, Haney J, Thomas EL. Biomarkers of metastatic potential in cultured adenocarcinoma clones. Clin Exper Metastasis. Accepted (2010). • Tipton DA, Seshul B, Dabbous MKh. Effect of bisphosphonates on human gingival fibroblast production of mediators of osteoclastogenesis: RANKL, OPG, and IL-6. Periodontal Res. Accepted (2010). • Tipton DA, Legan ZT, Dabbous MKh. Methamphetamine cytotoxicity and effect on LPSstimulated IL-1beta production by human monocytes. Toxicol In Vitro. 2010 Apr; 24(3):9217. • Adlam DJ, Dabbous MKh, Woolley DE. Electrochemical monitoring of rat mammary adenoarcinoma cells: An in vitro assay for anticancer drug selection. Assay Drug Dev Technol. 2008;6:795-802. • Tipton DA, Hamman NR, Dabbous MKh. Effect of myrrh oil on IL-1beta stimulation of NGkappaB activation and PEG(2) production in human gingival fibroblasts and epithelial cells. Toxicol In Vitro. 2006 Mar; 20(2):248-55. • Tipton DA, Woodard ES 3rd, Baber MA, Dabbous MKh. Role of c-myc proto-oncogene in the proliferation of hereditary gingival fibromatosis fibroblasts. J Periodontol. 2004 Mar; 75(3):360-9. • Tipton DA, Flynn JC, Stein SH, Dabbous MKh. Cycloozygenase-2 inhibitors decrease interleukin-1beta-stimulated prostaglandin E2 and IL-6 production by human gingival fibroblasts. J Periodontol. 2003 Dec; 74(12):1754-63. • Tipton DA, Lyle B, Babich H, Dabbous MKh. In vitro cytotoxic and anti-inflammatory effects of myrrh oil on human gingival fibroblasts and epithelial cells. Toxicol In Vitro. 2003 Jun; 17(3):301-10.
16
Research Funding: • National Institutes of Health • Private Industry • Private Foundations
FRANKLIN GARCIA-GODOY, D.D.S., M.S. Senior Executive Associate Dean of Research Chair, Department of Bioscience Research Director, Bioscience Research Center Professor, Department of Physiology, UTHSC Adjunct Professor, Department of Biomedical Engineering, University of Memphis Adjunct Professor, Department of Biomedical Engineering, Florida International University Senior Clinical Investigator, The Forsyth Institute, Boston, Massachusetts Adjunct Professor, Department of Conservative Dentistry and Periodontology, University of Munich Education: M.S., 1979, University of Illinois, Chicago D.D.S. 1976, Autonomous University of Santo Domingo (Dominican Republic) Office Phone: (901) 448-6333 Email: godoy@uthsc.edu
Research Interests: • Stem cell and tissue engineering • Biomaterials development and biocompatibility testing methods • Demineralization and remineralization • Dental erosion • Biofilm virulence
Page
Selected Publications: • Feilzer AH, Frankenberg R, Garcia-Godoy F, Kramer N. Long-term degradation of enamel and dentine bonds:6-year results in vitro vs. un vivo. Dent Mat. 2010 Sept; 26(11). • Garcia F, Murray PE, Garcia-Godoy F, Namerow KN. Effect of aquatine endodontic cleanser on smear layer removal in the root canals of ex vivo human teeth. J App Oral Sci. 2010 Aug;18(4):403-8. • Ayad M, Maghrabi AA, Garcia-Godoy F. Resin composite polyethylene fiber reinforcement: Effect on fracture resistance of weakended marginal ridges. Am J Dent. 2010 Jun; 23(3):133136 • Garcia-Godoy F, Kim HI, Kim YO, Ko CC, Kwon YH, Park SB, Son WS. Diode-pumped solidstate laser for bonding orthodontic brackets: effect of light intensity and light curing-time. Lasers Med Sci. 2010 Jun 8 [Epub ahead of print]. • Bahuleyan B, Chadipiralla K, Garcia-Godoy F, Huang CY, Murray PE, Stelnicki EJ, Yochim JM. Osteogenic differentiation of stem cells derived from human periodontal ligaments and pulp of human exfoliated deciduous teeth. Cell Tissue Res. 2010 May; 340(2):323-333. • Alvarez-Serrano S, Garcia-Godoy F, Pameijer CH, Zmener O. Sealing Properties of a calcium alumniate agent. Am J Dent. 2010 Apr; 23(2): 121-124.
17
Research Funding: • National Institutes of Health • Private Industry
EDWARD F. HARRIS, PH.D. Professor, Department of Bioscience Research Professor, Department of Orthodontics Professor, Department of Pediatric Dentistry Education: NIH Postdoctoral Fellow, 1977-1980, University of Connecticut Ph.D., 1977, Arizona State University, Tempe Office Phone: (901) 448-6265 Email: eharris@uthsc.edu
Research Interests: • Effects of age, sex, race, and environment on growth of the cranial complexes • Tooth mineralization • Tooth size, odontometrics • External apical root resorption Research Funding: • University of Tennessee College of Dentistry Alumni Endowment Fund
Page
18
Selected Publications: • Harris EF, Mincer HH, Anderson KM, Senn DR. Age estimation from oral and dental structures. In: Senn DR, Stimson PG, editors. Forensic dentistry, 2nd ed. Boca Raton, FL: CRC Press, 2010, p. 263-303. • Townsend GC, Harris EF, Lesot H, Clauss F, Brook AH. Morphogenetic fields within the human dentition: a new, clinically-relevant synthesis of an old concept. Arch Oral Biol. 2009;54(1):S34-S44. • Harris EF. Interpreting heritability estimates in the orthodontic literature. Sem Ortho. 2008;14:125-134. • Harris EF, Bodford K. Bilateral asymmetry in the tooth relationships of orthodontic patients. Angle Ortho. 2007;77:779-786. • Harris EF. Carabelli’s trait and tooth size of human maxillary first molars. Am J Phys Anthro. 2007;132:238-246. • Harris EF. Mineralization of the mandibular third molar: a study of American blacks and whites. Am J Phys Anthro. 2007;132:98-109. • Harris EF. Dental Development and anomalies in craniosynostosis and facial clefting. In: Mooney MP, Siegel MI, editors. Understanding Craniofacial Anomalies: The Etiopathogenesis of Craniosynostosis and Facial Clefting. New York: John Wiley-Liss, 2002, p. 425-467. • Harris EF. External apical root resorption resulting from orthodontic tooth movement. Sem Ortho. 2000;6:183-194. • Harris EF. Dental maturation. In: Ulijaszek SJ, Johnston FE, Preece MA, editors. The Cambridge Encyclopedia of Human Growth. Cambridge: Cambridge University Press, 1998, p.45-48.
CHRISTOPHER NOSRAT, D.D.S., PH.D. Professor, Department of Bioscience Research Director of Oral Cancer, Center for Cancer Research (UTHSC) Professor, Department of Anatomy and Neurobiology, College of Medicine (UTHSC) Education: Ph.D., 1997, Karolinska Institutet (Stockholm, Sweden) D.D.S., 1994, Karolinska Institutet (Stockholm, Sweden) Office Phone: (901) 448-2150 Email: cnosrat@uthsc.edu
Research Interests: • Oral cancer and inflammation • Oral cancer stem cells • Dental pulp stem cells and biological tissue engineering • Oral neurobiology • Chemosensation • Genetics and genomics • Transgenic technology • Translational research Research Funding: • National Institutes of Health (NIH) • U.S. Department of Defense
Page
19
Selected Publications: • Rao SK, Pavicevic Z, Du Z, Kim JG, Fan M, Jiao Y, Rosebush M, Samant S, Gu W, Pfeffer LM, Nosrat CA. Pro-inflammatory genes as biomarkers and therapeutic targets in oral squamous cell carcinoma. J Biol Chem. 2010;285(42):32512-21. • Ito A. Nosrat CA. Gustatory papillae and taste bud development and maintenance in the absence of TrkB ligands BDNF and NT-4. Cell Tissue Res. 2009;337:349-359. • Wong DY, Hollister SH, Krebsbach PH, Nosrat CA. Poly (epsilon-Caprolactone) and Poly (LLactic-Co-Glycolic Acid) degradable polymer sponges attenuate astrocyte response and lesion growth in acute traumatic brain injury. Tissue Eng. 2007;13:2515-23. • Nosrat IV, Smith CA, Mullally P, Olson L, Nosrat CA. Dental pulp cells provide neurotrophic support for dopaminergic neurons and differentiate into neurons in vitro; implications for tissue engineering and repair in the nervous system. Euro J Neurosci. 2004;19:2388-2398. • Agerman K, Hjerling-Leffler J, Blanchard MP, Scarfone E, Canlon B, Nosrat CA, Ernfores P. BDNF gene replacement reveals multiple mechanisms for establishing neurotrophin specificity during sensory nervous system development. Development. 2003;130:1479-1491. • Nosrat IV, Widenfalk J, Olson L, Nosrat CA. Dental pulp stem cells produce neurotrophic factors, interact with trigeminal neurons in vitro and rescue motoneurons after spinal cord injury. Develop Biol. 2001;238:120-132. •
MARK SCARBECZ, M.A., PH.D. Director, Planning and Assessment Professor, Department of Bioscience Research Faculty (Dental Science), College of Graduate Health Sciences Education: Ph.D., 1991, University of Arizona, Tucson M.A., 1983, University of Arizona, Tucson B.A., 1981, University of New York at Buffalo Office Phone: (901) 448-1211 Email: mscarbecz@uthsc.edu
Research Interests: • Demographic trends in the dental profession • Women in the dental profession • Dentist-patient relations • Relationship between subjective general health and subjective oral health • Scholarship of Teaching and Learning (SoTL)
Page
Selected Publications: • Bland PS, Patters MR, Scarbecz M, Shiloah J, Stein SH, Tipton DA. The effect of long-term aspirin intake on the outcome of non-surgical periodontal therapy in smokers. J Dent Res. 2010 Special Issue. • Brescica W, Hofmann P, Robinson MM, Russell CK, Scarbecz M, Sheid C, Scwab C, Shreve R. Assessing teaching activities on an academic health science center campus. Trans Dialog: Teaching and elearning. 2010 Mar;3(3). • Redmond DC, Scarbecz M. Dental practice transition: A practical guide to management (Book Review). J Dent Edu. 2009 Dec; 73:1423-1424. • Chaudhry J, Chaudhry S, Scarbecz M, Thomas R. Efficacy of high-resolution digital bitewings in diagnosing incipient proximal caries. J Dent Res. 2009; 88(Spec Iss A): 3346. • Donaldson ME, Gala A, Scarbecz M. Caries risk assessment in restorative pediatric dentistry. J Dent Res. 2009;89(Spec Iss A): 2524. • Scarbecz M. Critical Thinking, Understanding, and Evaluating Dental Research, 2nd ed. (Book Review). J Dent Edu. 2008 Oct;72(10): 1209-1210. • Gilpatrick RO, Harrison JA, Scarbecz M, Simon JF, Welk A, Wicks RA. Evaluation of the optimized integration of computer-assisted learning and simulation with 40 DentSim units into existing curriculum. Intl J Comput Dent. 2008;11:17-40. • Scarbecz M. Evidence-based dentistry resources for dental practitioners. J Tenn Dent Assoc. 2008 Spring;88(2):9-13. • Gilpatrick RO, Harrison JA, Maggio MP, Scarbecz M, Simon JF, Welk A, Wicks RA. Computerassisted learning and simulation lab with 40 DentSim units. J Comput Den. 2008;11(1):17-40. • Chaudhry J, Mincer HH, Scarbecz M. Cone-beam computed tomography analysis of alveolar canal location. J Dent Res. 2008;87(Spec Iss A): 0867.
20
Research Funding: • None at present
EDWIN L. THOMAS, M.S., PH.D. Professor, Department of Bioscience Research Professor, Department of Microbiology, Immunology, and Biochemistry Education: Ph.D., 1970, University of Michigan, Ann Arbor M.S., 1966, University of Michigan, Ann Arbor Office Phone: (901) 448-4879 Email: elthomas@uthsc.edu
Research Interests: • Innate immunity • Antimicrobial peptides of saliva, leukocytes, and epithelial cells • Peroxidase enzymes of leukocytes and saliva • Proteomics and biomarkers of human disease • Calcium-binding molecules and resistance of the teeth to damage by acid Research Funding: • University of Tennessee College of Dentistry Alumni Endowment Fund
Page
21
Selected Publications: • Dabbous MK, Jefferson MM, Haney L, Thomas EL. Biomarkers of metastatic potential in cultured adenocarcinoma clones. Clin Exp Metastasis. 2010 [In Press]. • Tipton DA, Pabst MJ, Thomas EL, Babu JP, Stein SH, Fry H. Association of high plaque levels of Prevotella intermedia with aggressive periodontitis in a 16-year-old female. Perio. 2006;3:115-122. • Thomas EL, Jefferson MM, Learn DB, King CC, Dabbous MK. Myeloperoxidase-catalyzed chlorination of histamine by stimulated neutrophils. Redox Reports. 2000;5:191-194. • King CC, Jefferson MM, Thomas EL. Secretion and inactivation of myeloperoxidase by isolated neurophils. J Leukocyte Biol. 1997;61:293-302.
DAVID A. TIPTON, D.D.S., PH.D.
Professor, Department of Bioscience Research Professor, Department of Periodontology Education: Ph.D., 1988, University of Memphis D.D.S., 1978, University of Tennessee College of Dentistry B.A., 1975, Vanderbilt University Office Phone: (901) 448-7200 Email: dtipton@uthsc.edu
Research Interests: • MMPs and inflammatory mediators in periodontal and TMJ disease • Effects of drugs and natural products on soft tissue cell production of mediators of bone metabolism • Cellular response to anti-inflammatory drugs and natural products • Gingival fibroblast production/regulation of ECM molecules and MMPs in gingival fibroses • Cellular response to dental biomaterials
Page
Selected Publications: • Tipton DA, Seshul BS, Dabbous MKh. Effect of bisphosphonates on the production of mediators of osteoclastogenesis (RANKL, OPG, and IL-6) by human gingival fibroblasts. J Periodont Res 2010; (Article online in advance of print) doi:10.1111/j.16000765.2010.01306.x • Tipton DA, Legan Z, Dabbous MKh. Methamphetamine cytotoxicity and effect on LPSstimulated IL-1β production by human monocytes. Toxicol In Vitro 2010; 24: 921-927. • Tipton DA, Pond DM. Effect of NF-κB inhibition on IL-1β-stimulated MMP-3 production by gingival fibroblasts from a patient with aggressive periodontitis. PERIO 2008; 5:187-196. • Tipton DA, Lewis JL. Effects of a hindered amine light stabilizer (HALS) and a UV light absorber (UVA) used in maxillofacial elastomers on human gingival epithelial cells and fibroblasts. J Prosth Dent 2008; 100:220-231. • Tipton DA, Gay D, DeCoster V. Effect of a COX-2 inhibitor on IL-1β-stimulated activation of the transcription factor NF-κB in human gingival fibroblasts. J Periodontol 2007; 78:542549. • Tipton DA, Pabst MJ, Thomas EL, Babu JP, Stein SH, Fry H. Association of high levels of Prevotella intermedia with aggressive periodontitis in a 16-year-old female. PERIO 2006; 3:115-122. • Tipton DA, Hamman NR, Dabbous MKh. Effect of myrrh oil on IL-1β stimulation of NF-kB activation and PGE2 production in human gingival fibroblasts and epithelial cells. Toxicol In Vitro 2006; 20:248-255.
22
Research Funding: • Private industry • University of Tennessee College of Dentistry Alumni Endowment Fund
ANTHEUNIS VERSLUIS, PH.D. Director, Biomaterials Professor, Department of Bioscience Research Education: Ph.D., 1994, University of Greenwich, London Ingenieur, 1988. Delft University of Technology, Delft, The Netherlands Office Phone: (901) 448-6263 Email: averslui@uthsc.edu
Research Interests: • Biomechanics (stress-strain analysis) applied to dental tissues, such as: o Restoration techniques o Polymerization shrinkage and hygroscopic expansion o Wear, failure, fracture, and fatigue of teeth, restorations, roots, and instruments o Orthodontic forces and tooth movement o Testing methods used in dental research
Page
Selected Publication • dos Santos AFV, Meira JBC, Tanaka CB, Xavier TA, Ballester RY, Lima RG, Pfeifer CS, Versluis A. Can fiber posts increase root stresses and reduce fracture? J Dent Res. 2010;89:587-597. • Kim HC, Lee MH, Yum J, Versluis A, Lee CJ, Kim BM. Potential relationship between design of NiTi rotary instruments and vertical root fracture. J Endodont. 2010;36:1195-1199. • Boaro LCC, Gonvalves F, Guimaraes TC, Ferracane JL, Versluis A, Braga RR. Polymerization stress, shrinkage, and elastic modulus of current low-shrink restorative composites. Dent Mater. 2010;26:1144-1150. • da Silva NR, Raposo LHA, Versluis A, Soares CJ. The effect of post, core, crown type, and ferrule presence on the biomechanical behavior of endodontically treated bovine anterior teeth. J Prosthet Dent. 2010;104:306-3017. • Kanjanaouthai A, Mahatumarat K, Techalertpaisarn P, Versluis A. The effect of inclination of a maxillary central incisor on the moment to force ratio: finite element method. J Thai Assoc Orthodont. 2010;9:24-32. • Parco TM, Tantbirojn D, Versluis A, Feigal RJ, Beiraghi S. Microleakage of self-etching sealant on non-contaminated and saliva-contaminated enamel. Pediat Dent. 2010;in press. • Hur B, Kim HK, Park JK, Versluis A. Characteristics of noncarious cervical lesions – an ex vivo study using micro computed tomography. J Oral Rehab. 2010;in press. • Versluis A, Tantbirojn D, Lee MS, Tu LS, DeLong R. Can hygroscopic expansion compensate polymerization shrinkage? Part I: Deformation of restored teeth. Dent Mater. 2010;in press. • Meira JBC, Braga RR, Ballester RY, Tanaka CB, Versluis A. Understanding contradictory data in contraction stress tests. J Dent Res. 2010;in press. • Tantbirojn D, Chongvisal S, Augustson DG, Versluis A. Hardness and post-gel shrinkage of preheated composites. Quint Intl. 2010;in press.
23
Research Funding: • Private Industry
DENTAL RESEARCH STAFF
Laurel Wedel, M.A. Grants & Clinical Research Coordinator lwedel1@uthsc.edu (901) 448-2210
BIOMATERIALS RESEARCH CENTER
Nancy Pecora, B.S.C., B.A., M.B.A. Research Coordinator npecora@uthsc.edu (901) 448-6263
BIOSCIENCE RESEARCH CENTER
Yanhui Zhang, Ph.D. Research Associate yzhang36@uthsc.edu (901) 448-6333
CANCER RESEARCH CENTER
Irina Vukmanovic Nosrat, D.D.S. Research Team Leader ivukmano@uthsc.edu (901) 448-1254 Shailaja Kishan Rao, Ph.D. Post-Doctoral Research Fellow skishan@uthsc.edu (901) 448-1963 Michelle Sims, B.S. Research Coordinator msims7@uthsc.edu (901) 448-2151
Kimberly S. DeMonaco, R.D.H. Clinical Research Associate kdemonac@uthsc.edu (901) 448-2794
CRANIOFACIAL RESEARCH CENTER Margaret Jefferson Sr. Research Assistant mjefferson@uthsc.edu (901) 448-6058
Iva Pendleton Admin. Service Assistant ipendleton@uthsc.edu (901) 448-6167 Geraldine Moore Lab Assistant gmoore6@uthsc.edu (901) 448-6167
TMD/SLEEP DISORDER CLINIC Brandy Clark, CDA, RDA Clinical Dental Assistant bclark28@uthsc.edu (901) 448-1285 Linda Vincent Clinic Coordinator lvincen1@uthsc.edu (901) 448-1285
24
Nancy Turner Administrative Aide nturner@uthsc.edu (901) 448-6333
CLINICAL RESEARCH CENTER
Page
ADMINISTRATION
PART B: Funded Research Faculty
Page
25
The following is a list of funded research faculty. The first section lists all faculty who hold federal, industrial, or foundation research grants. The second section lists all faculty who hold Dental Alumni research grants. Contact information and project titles are provided.
FEDERAL, INDUSTRIAL, FOUNDATION Grants
The following is a list of faculty members who are principal investigators on federal, industrial, or foundation research grants. Titles, sponsors, expirations, and abstracts are provided for each grant. Faculty are listed alphabetically by last name.
JEGDISH BABU, B.S., M.S., PH.D.
Professor, Department of Bioscience Research Phone: Email:
(901) 448-4342 jbabu@uthsc.edu
Influence of cranberry juice components on denture related stomatitis and inflammatory reactions of gingival fibroblasts Sponsor: Cranberry Institute of Wisconsin Until: July 31, 2011 Abstract: This study investigates the role of high molecular weight components isolated from cranberry juice in the prevention of fungal biofilm formation on denture material. Additionally, the study also focuses on suppression of highly inflammatory cytokines and metalloproteinases by human gingival fibroblasts.
JOEL BUMGARDNER, PH.D.
Adjunct Professor, Department of Bioscience Research Associate Professor, Joint Biomedical Engineering Program – UTHSC and University of Memphis
Dual delivery of growth factors and/or antibiotics from chitosan-composites for bone regeneration Sponsor: Department of the Army, US Army Medical Research Program Until: September 30, 2010 Abstract: Development of a chitosan calcium sulfate resorbable dual delivery vehicle for antibiotics and growth factors to prevent infection and stimulate healing in catastrophic orthopedic injuries.
26
(901) 678-5253 jbmgrdnr@memphis.edu
Page
Phone: Email:
FRANKLIN GARCIA-GODOY, D.D.S., M.S.
Senior Executive Associate Dean, UTHSC College of Dentistry Chair, Department of Bioscience Research Director, Bioscience Research Center Professor, Department of Physiology, UTHSC Adjunct Professor, Dept. of Biomedical Engineering, University of Memphis Adjunct Professor, Dept. of Biomedical Engineering, Florida International University Senior Clinical Investigator, The Forsyth Institute, Boston Adjunct Professor, Department of Conservative Dentistry and Periodontology, University of Munich Phone: Email:
(901) 448-6333 godoy@uthsc.edu
The biocompatibility screening of restorative treatments Sponsor: NIH – NIDCR (R56) Until: August 31, 2011 Abstract: The goal of this study is to screen the biocompatibility of restorative dental treatments.
A study to assess the effects of glycolysis and regrowth activity of three marketed mouth rinses compared to a negative control Sponsor: P&G Until: Spring 2011 Abstract: Validation clinical trial to test three mouth rinses compared to a negative control.
LIANG HONG, D.D.S., M.S., PH.D.
Associate Professor, Department of Pediatric Dentistry and Community Oral Health Director, Community Oral Health
Development of miniature plasma brush for dental clinical applications Sponsor: NIH-NIDCR (R44 – SBIR Phase II) Until: June 30, 2012 Abstract: The main objective of this project is to develop a miniature atmospheric cold plasma brush (m-ACPB) for dental clinical applications.
27
(901) 448-6206 lhong3@uthsc.edu
Page
Phone: Email:
ADAM LLOYD, B.D.S., M.S.
Assistant Professor, Department of Endodontics Phone: Email:
(901) 448-1793 alloyd@uthsc.edu
Visualization of sealer movement during single-cone obturation with EndoSequence BC Sealer Sponsor: Real World Endodontics/Brasseler USA Until: N/A Abstract: Assess movement of a bioceramic sealer into the intricacies of root canal anatomy during single-cone obturation.
CHRISTOPHER NOSRAT, D.D.S., PH.D.
Professor, Department of Bioscience Research Phone: Email:
(901) 448-2150 cnosrat@uthsc.edu
Neurotrophin specificity and function in the taste system Sponsor: NIH-NIDCD (R01) Until: June 30, 2011 Abstract: Investigation of the roles of neurotrophins, and in particular, BDNF during development and in the adult taste system. Working to generate and analyze novel transgenic mice as part of this study.
Page
28
Neurotrophin specificity and function in the taste system Sponsor: NIH-NIDCD ARRA Supplement to R01 Until: March 31, 2011 Abstract: Analyzing taste transgenic mice using laser capture micro-dissected taste tissue, microarray analysis and bioinformatics.
DAVID A. TIPTON, D.D.S., PH.D.
Professor, Department of Bioscience Research Professor, Department of Periodontology Phone: Email:
(901) 448-7220 dtipton@uthsc.edu
Page
29
Influence of cranberry components on gingival epithelial cell production of bone resorptive mediators and adherence of periodontopathogens Sponsor: The Cranberry Institute of Wisconsin Until : (pending) Abstract: The goals of this study are to determine whether cranberry NDM interferes with aspects of pathogenesis of periodontitis, namely inhibition of adherence of periodontopathogens to human gingival epithelial cells, and LPS-stimulated gingival epithelial cell production of molecules that degrade, or promote degradation, of periodontal bone
UT DENTAL ALUMNI ENDOWMENT FUND Grants
The following is a list of active UT Dental Alumni Endowment Grants. Projects are listed alphabetically by title, with faculty names and email addresses , and project expirations.
ď ś A comparison of the effects of occlusal adjustment and splint therapy on symptoms reduction in TMD Investigator(s): SWATI AHUJA, B.D.S., M.D.S., D.D.S. Assistant Professor, Department of Prosthodontics Phone: Email:
(901) 448-7180 sahuja@uthsc.edu
DAVID CAGNA, D.M.D., M.S. Director, Graduate Prosthodontics Professor, Department of Prosthodontics
June 2012
30
Project Period Ends:
(901) 448-6930 dcagna@uthsc.edu
Page
Phone: Email:
ď ś An ultra-structural evaluation of the resin-dentin bond in root canals conditioned with phosphoric acid and ethylenediamine tetra-acetic acid Investigator(s):
PETER DIFIORE, D.D.S. Chair and Professor, Department of Endodontics Phone: Email:
(901) 448-6618 pdifiore@uthsc.edu
JEFF PHEBUS, D.D.S. Assistant Professor, Department of Endodontics
April 2011
31
Project Period Ends:
(901) 448-6438 jphebus@uthsc.edu
Page
Phone: Email:
ď ś Can dental students be trained to read dental radiographs for osteoporosis screening? Investigator(s):
JOHN COVINGTON, D.D.S., M.S. Chair and Professor, Department of Biologic & Diagnostic Sciences Phone: Email:
(901) 448-8609 jcovingt@uthsc.edu
CESAR MIGLIORATI, D.D.S., M.S., PH.D. Professor, Department of Biologic & Diagnostic Sciences Director, Division of Oral Medicine
February 2011
32
Project Period Ends:
(901) 448-2613 migliorati@uthsc.edu
Page
Phone: Email:
ď ś Differences between adults and adolescents in RANKL and osteoprotegerin levels response to orthodontic force Investigator(s):
EDWARD HARRIS, PH.D. Professor, Department of Bioscience Research Professor, Department of Orthodontics Phone: Email:
(901) 448-6265 eharris@uthsc.edu
DAVID TIPTON, D.D.S., PH.D. Professor, Department of Bioscience Research Professor, Department of Periodontology
June 2012
33
Project Period Ends:
(901) 448-7220 dtipton@uthsc.edu
Page
Phone: Email:
ď ś Distribution and osteogenic potential of mesenchymal stem-like periodontal ligament cells in periodontal health and disease Investigator(s):
ANASTASIOS KARYDIS, D.D.S., M.S., PH.D. Assistant Professor, Department of Periodontology Phone: Email:
(901) 448-6242 akarydis@uthsc.edu
SWATI RAWAL, B.D.S., M.D.S., M.S. Director, Graduate Periodontics Assistant Professor, Department of Periodontology Phone: Email:
(901) 448-1963 srawal@uthsc.edu
YESHWANT RAWAL, B.D.S., M.D.S., M.S. Assistant Professor, Department of Biologic & Diagnostic Sciences Phone: Email:
(901) 448-6241 yrawal@uthsc.edu
JACOB SHILOAH, D.D.S., D.M.D. Professor, Department of Periodontology Phone: Email:
(901) 448-6242 jshiloah@uthsc.edu
Phone: Email:
(901) 448-7220 dtipton@uthsc.edu August 2011
Page
Project Period Ends:
34
DAVID A. TIPTON, D.D.S., PH.D. Professor, Department of Bioscience Research Professor, Department of Periodontology
ď ś Evaluation of three-point flexural strength, maximum flexural loading and flexural modulus, under thermal cycling, of extracted endodontically prepared human teeth using a prefabricated glass fiber reinforced composite post system Investigator(s): No
Photo
Available
ADAM DAVIS, D.D.S. Instructor, Department of Endodontics Phone: Email:
N/A N/A
BARRY MARK OWENS, D.D.S. Associate Professor, Department of Restorative Dentistry Phone: Email:
(901) 448-6275 bowens@uthsc.edu
JEFF PHEBUS, D.D.S. Assistant Professor, Department of Endodontics
October 2011
35
Project Period Ends:
(901) 448-6438 jphebus@uthsc.edu
Page
Phone: Email:
Geographic Variability in the Tempos of Tooth Formation in the United States Investigator(s): EDWARD HARRIS, PH.D. Professor, Department of Bioscience Research Professor, Department of Orthodontics Phone: Email: Project Period Ends:
(901) 448-6265 eharris@uthsc.edu May 2011
Invited Lectureships in Prosthodontics Investigator(s): DAVID CAGNA, D.M.D., M.S. Director, Graduate Prosthodontics Professor, Department of Prosthodontics
June 2011
36
Project Period Ends:
(901) 448-6930 dcagna@uthsc.edu
Page
Phone: Email:
Page
37
SECTION II: Students in Research
Page
38
STUDENTS IN Dental Research
FOR STUDENTS in Dental Research The College of Dentistry uses a variety of tools to improve human oral health, two of which are education and research. In recent years, the College has worked to expand its student research opportunities, creating an overlap between education and research, and helping students to better prepare for their future in dentistry.
Whereas research is more common in post-doctoral and residency programs, in the predoctoral program, there are many opportunities for students to enjoy research training and receive hands-on experience conducting research in one of the dental research laboratories and clinics on campus (for a list of Dental Research Centers, please refer to page 7).
For most UT dental students, the first opportunity to get involved in research will be during the summer after the first year of dental school (end of D1). During this summer session, students will have the most time to dedicate to research. However, limited time is also available at the end of the second year (D2) with varying amounts of additional time allotted in the following year to writing abstracts and presenting posters at meetings (such as the Hinman Student Research Symposium and IADR/AADR annual meetings). For students in their third and fourth year (D3 and D4) who are interested in participating in research, individual research electives can also be arranged for the duration of one semester.
Page
39
In regards to funding for research, a modest stipend is available for a limited number of students to participate in the Student Summer Research Program, which is funded by the UT Dental Alumni Research Training Award (see Alumni Research Training Award section for more information about this program). Students are encouraged to apply for private and federal grants and fellowships as well.
Page
40
STUDENT RESEARCH Training Program At the University of Tennessee College of Dentistry (CoD), student research is a highly valuable scholarly activity, viewed as an integral component of the academic experience. Therefore, College administrators make it a priority to provide students with a variety of research opportunities, and, starting at new student orientation, faculty stress the important of engaging in research during at least one of the four years on campus.
The CoD Student Research Program for pre-doctoral students provides funding for student research projects. This program was initiated in 1974, at which time limited funding was available to two students through the L.G. Noel Foundation. Over the next several years, interest in this program grew and attracted 18-20% o f incoming students each year. To provide more funded research opportunities and promote student participation in research, College administrators established the Summer Research Training Program. This program was supported by an NIH training grant awarded to UT CoD by the National Institute of Dental and Craniofacial Research (NIDCR). This T35 grant continued for ten years before it was phased out in 2005.
In the wake of the loss of NIDCR funding, the UT Dental Alumni Association, in recognizing the importance of this student research program, committed funds for the Summer Student Research Training Program, for a period of ten (10) years. This current program for predoctoral students has been described by reviewers at NIDCR as a “model program� for other dental schools.
Page
41
This program provides stipends for ten (10) dental students per year. During the summer, students receiving funding will engage in individualized research projects under the guidance and expertise of a faculty investigator who specializes in basic science, clinical science, or translational research. Students will work with their faculty mentor in his/her laboratory or clinic for the duration of eight (8) to ten (10) weeks. After this time, students will be required to present their research data in an oral presentation to their colleagues, faculty, and dental alumni. Student researchers will also be encouraged to present their research at national and international forums (including AADR/IADR meetings and the Hinman Student Research Symposium). All student researchers will be required to present their research as table clinics or posters at the annual Student Research Day held on campus each February.
DETAILS OF THE PROGRAM: The Alumni Student Research Training program provides an opportunity for dental students to participate in cutting edge research experiences. The research training which the students receive individually allows the students to have an excellent opportunity for professional and academic growth, and it introduces students to different career opportunities in dental research and academic dentistry. DETAILS ON THE PROGRAM: Stipend: Duration: Eligibility: Application: Deadline:
$1,200 per month*
1-2 months (summer)
Any UTHSC dental student in good academic standing
Available in the Craniofacial or Bioscience Research Center Annually by February 1st
FOR MORE INFORMATION, PLEASE CONTACT: Craniofacial Research Center (901) 448-6167 - Or -
Bioscience Research Center (901) 448-6333
Page
42
_________________________________________________________________________________________________________ * A travel allowance will be provided to students for presenting their abstracts at the AADR/IADR annual meetings.
SELECTING A RESEARCH MENTOR: The first step to engaging in research in the College of Dentistry is to explore research topics and project ideas. It is important to find research that not only has practical value, but also fascinates you. Keep in mind that it is not necessary to narrow your interests to one specific topic – your faculty research mentor can help you further develop the details of your research proposal. In order to find a faculty research mentor whose interests align with your own, use these hints for selecting a research mentor:
1) Review Section I: Faculty in Bioscience Research of this handbook. Faculty who are currently engaged in research are listed alphabetically with a brief synopsis of their research interests. Thoroughly read through each individual’s research interests and use the contact information provided to set a meeting to discuss your interests further. Also, review the list of the previous summer’s mentors for your potential mentor.
2) Set up a consultation with Dr. Franklin Garcia-Godoy, Senior Executive Associate Dean for Research (901-448-6333 or godoy@uthsc.edu), to discuss your research interests and receive feedback from him regarding the feasibility of your research topic and suggestions for which faculty might best serve as your mentor.
3) Talk to a D2, D3, or D4 student and ask for references. Seek out those students who have participated in the program in previous years. 4) Talk to your faculty, particularly those for the classes that you enjoy or in areas where you feel your interests reside.
Page
43
5) Do a little background research into your topic; read journal articles related to your topic and arm yourself with support for your research.
2010 STUDENT SUMMER RESEARCH MENTORS:
JEGDISH BABU, B.S., M.S., PH.D. Professor, Department of Bioscience Research Phone: Email:
(901) 448-4342 jbabu@uthsc.edu
BERNARD BLEN, D.D.S. Assistant Professor, Department of Restorative Dentistry Phone: Email:
(901) 448-4489 bblen@uthsc.edu
MUSTAFA KH. DABBOUS, PH.D. Professor, Department of Bioscience Research Professor, Department of Molecular Sciences Phone: Email:
(901) 448-6167 mdabbous@uthsc.edu
LAURA DARNELL, D.M.D., PH.D. Assistant Professor, Department of Restorative Dentistry
44
(901) 448-6271 ldarnell@uthsc.edu
Page
Phone: Email:
FRANKLIN GARCIA-GODOY, D.D.S., M.S. Senior Executive Associate Dean for Research Phone: Email:
(901) 448-6333 godoy@uthsc.edu
JANET HARRISON, D.D.S. Chair and Professor, Department of Restorative Dentistry Phone: Email:
(901) 448-6692 jharrison@uthsc.edu
ROBERT HATCH, D.D.S. Assistant Professor, Department of Restorative Dentistry Phone: Email:
(901) 448-4489 rhatch1@uthsc.edu
WAINSCOTT HOLLIS, D.D.S. Assistant Professor, Department of Prosthodontics
45
(901) 448-6288 whollis@uthsc.edu
Page
Phone: Email:
SWATI RAWAL, B.D.S., M.D.S., M.S. Assistant Professor, Department of Periodontology Director, Graduate Periodontics Phone: Email:
(901) 448-1963 srawal@uthsc.edu
JAMES SIMON, D.D.S. Professor, Department of Restorative Dentistry Director, Esthetic Dentistry Phone: Email:
(901) 448-6641 jfsimon@uthsc.edu
EDWIN L. THOMAS, B.A., M.S., PH.D. Professor, Department of Bioscience Research Phone: Email:
(901) 448-4879 elthomas@uthsc.edu
DAVID A. TIPTON, D.D.S., PH.D. Professor, Department of Bioscience Research Professor, Department of Periodontology
46
(901) 448-7220 dtipton@uthsc.edu
Page
Phone: Email:
WALETHA WASSON, D.D.S. Associate Professor, Department of Restorative Dentistry
47
(901) 448-6910 wwasson@uthsc.edu
Page
Phone: Email:
STEPS TO FOLLOW: Now that you know that you want to participate in research, follow the steps listed below to begin the process: 1) Make an appointment with the Senior Executive Associate Dean for Research, Dr. Franklin Garcia-Godoy, to discuss research interests and possible faculty mentors. 2) Contact the Grants & Clinical Research Manager (448-2210) or the Craniofacial Research Center (448-6167) to pick up the application guidelines.
3) Call your prospective mentor to arrange for a meeting to discuss your interest in research and ask him/her for input on research topics. This should be completed between September and January before the summer in which you want to do research. 4) Work with your mentor to develop a simple proposal. 5) Submit your application by February 1st (annually).
6) An ad hoc committee will review all applications and will choose the ten (10) grant recipients according to the follow criteria: • Scientific merit • Feasibility of project completion during project period • Clarity and conciseness
7) Award notifications will be sent by March 15th (annually).
Page
48
8) For those who receive an award: You will be responsible for arranging the start date with your mentor and the schedule for your summer research – make sure to build flexibility into that schedule and keep in consideration major holidays and/or vacations.
STUDENT Research Day The College of Dentistry hosts an annual Student Research Day, which provides dental students, who are engaged in research projects, with an opportunity to present their work on a local platform. Classes are canceled and the clinics are closed in the afternoon to encourage all students and faculty to attend the event and benefit from a rich, educational experience.
The annual event is held in mid-February, in the Schreir Auditorium, located in the Students Activity Center (SAC) on Madison Avenue.
The program includes a key note lecture by a world-class speaker in Oral Translational Research. The lecture is followed by an afternoon of presentations. Students may choose to present their work in table clinic or poster form.
Presentations are judged by a panel of faculty and alumni representatives. Students compete for several honors to be awarded. Honors include: •
• •
The Student Clinician Award for the Most Outstanding Presentation (sponsored by Dentsply/ADA) The student who receives this honor will be awarded a trip to the ADA annual meeting to present his/her research project
The Harold Cloogman Award for the Best Summer Research Program project The James C. Ragain Awards for Student Summer Research Program projects in 2nd, 3rd, 4th, and 5th places.
Page
49
Also presenting at the Student Research Day are Graduate Medical Education Students. These advanced students will compete for the Graduate Program Research Award.
HINMAN STUDENT Research Symposium The Hinman Student Research Symposium was established in 1995 to highlight student achievements in research. The Hinman is co-sponsored by the Thomas P. Hinman Dental Society and the University of Tennessee College of Dentistry, with participation of the National Institute of Dental and Craniofacial Research, the ADEAGies Foundation, the Procter & Gamble Company, Colgate, and the Tennessee Dental Association Foundation.
The Hinman Student Research Symposium is held every year at the Historic Peabody Hotel in Memphis, which is centrally located in the Mid-South, right along the Mississippi. The Symposium consists of competitive, scientific sessions with awards for the best presentations, a banquet with a nationally acclaimed key-note speaker, exhibits, and numerous networking opportunities as well as touring the “beautiful Bluff City.”
The Hinman begins on a Friday at noon, consisting of registration and poster set-up. This is followed by a reception and welcome banquet. The Symposium continues on Saturday with both morning and afternoon scientific sessions and many opportunities for fun and more networking. But the Hinman isn’t all academia. Following a tour of Elvis Presley’s Graceland Mansion, you’ll be on your own for the evening on Beale Street, “Home of the Blues.” On Sunday, the scientific sessions will continue in the morning and close with the presentation of awards.
Outside of the Hinman Student Research Symposium, and the activities listed above, Memphis offers many more opportunities for exploration – from the Pyramid to Sun Studios to boat tours on the Mississippi to the lesser known but worthwhile National Civil Rights Museum, Pink Palace Museum, Brooks Art Gallery, Dixon Gardens, and the unique Ornamental Metal Museum. Tree-shaded parks and neighborhoods, good food, and warm Southern hospitality await you.
Page
50
For further information, please visit the Hinman Symposium online at: www.uthsc.edu/dentistry/admission/hinman
PRESENTATIONS at the Hinman
Page
51
THE HISTORIC PEABODY HOTEL MEMPHIS, TN
Page
52
HINMAN STUDENT RESEARCH SYMPOSIUM OCTOBER 29-31, 2010
January 2011
THE
UNIVERSITY of TENNESSEE HEALTH SCIENCE CENTER College of Dentistry 875 Union Avenue
Memphis, TN 38163-0001
Page
Edited by Laurel Wedel, M.A. Communications Specialist Grants & Clinical Research Coordinator
53
(901) 448-6200