The University of Zurich is not only the largest Swiss university, it is also a highly respected research university at which interdisciplinarity is systematically integrated into all academic activities.
Interdisciplinarity brings a holistic view to what are otherwise highly specialized education courses. It removes the blinkers from our students and researchers and enables – sometimes even forces – them to view problems from other perspectives which have their own, wellfounded arguments. As a result, researchers can come up with new, innovative approaches, develop more holistic methods, and give better answers to the pressing questions of our time.
The Technology Platforms of the University of Zurich have emerged from successful disciplinary and interdisciplinary research networks and embody this holistic approach by making state-of-the-art technology accessible to all University of Zurich researchers and enabling them to use it correctly. In collaboration with staff and thanks to the contact with other disciplines, new questions can be asked, new methods developed, and new cooperation projects initiated. All of this can
happen irrespective of the subject or the academic level of the users. In short, the subjects and disciplines lose their technological limitations, enabling Zurich researchers to research their holistic approaches with holistic methods. The joint use of high-end technologies creates synergies and enables a strategic deployment of resources that would be inconceivable without the Technology Platforms.
This advantage is why more and more researchers opt for the University of Zurich. They are aware that it is impossible to tackle today’s complex challenges with isolated research and outdated equipment and knowledge.
The purpose of this brochure is to show you the research infrastructure that researchers can access at the University of Zurich in order to achieve their research goals and thus meet today’s multi-dimensional requirements.
Elisabeth Stark Vice President Research
Principle of Technology Platforms
Good research succeeds when brilliant minds collaborate with their networks. Cutting-edge research also requires state-of-the-art infrastructure operated by experts of scientific methods that allows researchers to study the scientific questions they are working on with the latest methods.
The University of Zurich’s Technology Platforms enable researchers to use high-end infrastructure with state-of-the-art methods, provide support with the handling of complex data sets and the production of customer-specific tools. The most important success factor for the Technology Platforms is their staff, with their proven specialist expertise. They enable researchers to work on scientific questions that are highly demanding from a methodological perspective. With the help of the Technology Platforms, a theologian might be able to have biblical objects scientifically examined in order to determine their age, origins, and production methods.
In addition, knowledge of the latest methodological possibilities can have an inspiring effect on the development of research questions. The integration of Technology Platforms into the concept phase of a research project therefore has some decisive advantages. The Technology Platforms advise researchers of any field about the potential of their methods and give comprehensive consulting on how to apply them. Unusual inquiries and new technology opportunities motivate the Technology Platforms to develop new services.
Primarily, the Technology Platforms create added values for research. In addition, UZH greatly appreciates the cost-reducing effect by the shared and managed use of expensive research infrastructures.
In order to increase the Technology Platforms’ efficacy, the Strategic Research Platforms department works continuously to improve the conditions for the platforms’ operations to realize potential synergies and let researchers benefit thereof. In addition, the department promotes the visibility of the Technology Platforms’ services, in particular beyond the boundaries of a specific research field. The department maintains national and international networks to implement best practice approaches in the management of Technology Platforms.
After all, many valuable innovations arise from interdisciplinary research. Discover the possibilities in this brochure in an easy-to-understand format.
Two important types of Technology Platforms are specifically labeled in this brochure:
Type 1: The approved Technology Platforms are of strategic importance for the research success of UZH. In most cases approved Technology Platforms serve researchers from different faculties.
Type 2: The national Technology Platforms have undergone an evaluation and have been qualified as an outstanding research infrastructure by international experts. They are listed on the Roadmap for National Research Infrastructure.
Type 1 and 2 combined: Some Technology Platforms correspond to both types.
Location University of Zurich Contact thomas.trueb@uzh.ch https://www.research.uzh.ch/en/infrastructure/platforms.html
Center for Microscopy and Image Analysis (ZMB)
Microscopy: An Indispensable Method for Studying the Structure of Life
Microscopy enables scientists to gain insights into the structures and functions of proteins and organelles in cells, tissue, and organisms. This knowledge revolutionizes research and makes a key contribution to understanding the microstructure of materials, the function of cells and organs and promoting medical developments and technological innovation.
The Center for Microscopy and Image Analysis (ZMB) offers all important, state-of-the-art light and electron microscopes for scientific research. With this equipment, research projects can be conducted in all areas of biomedicine and materials science. One outstanding strength of the ZMB is that it provides the option to study both living and fixed samples and to correlate data from different technologies, such as light and electron microscopy. This significantly expands the range of research options available.
The ZMB also operates state-of-the-art data processing infrastructure for researchers to analyze the data collected. In addition, the center offers comprehensive support for scientists, including training in the required techniques. Researchers have the option to have their samples processed by the ZMB service, and data can be evaluated in close collaboration with the center. This holistic support not only benefits research but also enables the use of new scientific approaches.
Who we are:
The ZMB is a specialized Technology Platform for light and electron microscopy.
Our services:
• Microscopy and image processing for teaching
• Sample preparation and microscopic analysis
• Data and image processing
• Our extensive span of microscopy technology includes:
- Fluorescence microscopy
- Slide scanning
- Confocal laser scanning microscopy, including spinning disk microscopy
- High-content screening microscopy
- Fluorescence lifetime imaging
- Light-sheet microscopy for small model organisms and large samples
- Multiphoton microscopy
- Transmission electron microscopy including elemental analysis
- Scanning electron microscopy, including array tomography and elemental analysis
- Cryo-electron microscopy for single proteins and tilt tomography
- Focused ion beam scanning electron microscopy at cryo- and room temperature
Examples of three research projects:
To histologically test the reaction of a human placenta to medication treatment, placenta samples are shock-frozen using cryotechnology, cut into ultra-thin slices, and examined with the help of optical nanoscopy to produce high-resolution images.
An art historian doubts the authenticity of a medieval painting. To determine its age, the composition of the paints is studied under a light microscope.
Various harmful substances are administered to a tumor cell. To observe the changes in the structure of the cells, chemicals are applied during the sample preparation to render the cell walls transparent.
Locations
• Irchel Campus
• Schlieren Campus
• City Campus
• Lengg Campus/ Balgrist Campus
• Botanical Garden Campus Contact info@zmb.uzh.ch
www.zmb.uzh.ch
BioVisionCenter (BVC)
Making Large-Scale Automated Microscopy Image Analysis Accessible to All
Computer algorithms relying on artificial intelligence allow turning the visual information captured by microscopes into measurements that provide quantitative insights into living systems, from the structure of the nanometer-small intracellular components seen in electron microscopy to the behavior of fruit flies observed with our bare eyes.
Thanks to modern imaging technologies, vast amounts of information-rich image data are acquired every day, at scales that range from molecules to full organisms. However, glancing at these beautiful images is not sufficient: in order to gain scientific insight, the visual information captured by microscopes must be turned into unambiguous and reproducible measurements. Images therefore come with the massive challenge of analyzing each one of them in a quantitative manner, which is made possible by algorithms relying on artificial intelligence. Unfortunately, these novel tools are only accessible to a handful of computational scientists as their use requires advanced expertise in programming and data science.
The BioVisionCenter works with researchers at the University of Zurich, academic institutions across Switzerland and abroad, as well as industry partners to facilitate the access to state-of-the-art bioimage analysis tools and unleash their potential in biology. The resources developed by the BioVisionCenter empower life scientists to analyze large-scale bioimage datasets, without requiring advanced computational skills. Additionally, the BioVisionCenter also supports those developing novel image analysis algorithms in making their contributions more visible and accessible to potential users.
Who we are:
The BioVisionCenter democratizes the access to advanced analysis methods for large microscopy images.
Our services:
• Core development of an open-source software platform (Fractal) incorporating state-of-the-art analysis tools
• Deploy and maintain Fractal instances on the local high performance compute cluster at UZH and partner institutions
• Bring together Fractal users and developers at monthly power user meetings to elaborate new tools for image analysis
• Provide bioimage analysis support and project design coaching as expert technical advice or in direct collaborations
• Organize training activities (e.g., summer schools, workshops) to promote the acquisition of bioimage analysis expertise for scientists at all career stages
• Develop FAIR (Findable, Accessible, Interopera ble, and Reproducible) standards for bioimage analysis pipelines by releasing all contributions under permissive open licenses
Examples of three research projects:
To understand how heart cells are formed, they can be grown in cell culture and imaged with high-resolution microscopy. Artificial intelligence tools then allow automating the analysis of thousands of cells in the images and figuring out the developmental path that these cells are taking.
Our gut is constantly renewing and creating new cells. In vitro organoid systems can be used to better understand how different gut cells are formed. These so-called intestinal organoids are imaged at a high resolution, resulting in information-rich 3D pictures from which cell types can be defined relying on advanced image analysis.
To understand how drugs affect human cancer cells, their effects can be studied in cell culture systems. Millions of cells are then imaged after a drug treatment and image analysis allows understanding the drug’s effects in detail, even when these effects are too subtle to be noticeable by human eyes.
Magnetic resonance imaging (MRI) uses magnetic fields and radio waves rather than x-rays. As a result, patients are not exposed to any harmful radiation during a scan.
Nuclear spin
Normally, all atomic nuclei in the body rotate around their own axes. This is known as the atom’s nuclear spin. The nuclear spin generates a small magnetic field. Hydrogen atoms are particularly important for MRI as they are the most common atoms in the body.
Under natural conditions, the magnetic moment of the hydrogen nuclei is completely random. However, if the body is exposed to a strong external magnetic field, the spins of the atomic nuclei align – in the longitudinal direction of the magnetic field.
Magnetic fields and radio waves
Magnetic resonance imaging uses the principle of aligned nuclear spins. The MRI scanner produces a magnetic field that is very strong but at the same time completely harmless to humans. In addition to this magnetic field, the MRI scanner also emits high-frequency radio waves into the body during the measurements. The radio wave pulses change the parallel alignment of the hydrogen nuclei. After every radio wave pulse, the hydrogen nuclei return to the longitudinal alignment dictated by the magnet. In the process, the nuclei emit magnetic signals, which are measured and processed to form images of the body’s structure.
However, this alone does not provide usable images of the body’s organs and structures. For that reason, additional magnetic fields are applied to the body using what are known as ‘coils.’ These additional magnetic fields make it possible to depict a region of the body from different angles.
Measurement of the water content in tissue
The water content determines the intensity of the signals in an MRI scan. This enables the different tissue types to be differentiated on the images obtained –for example, healthy versus diseased tissue.
By taking several MRI images in immediate succession and then connecting them digitally, physical functions and processes, such as the functioning of the brain, can also be observed. Thanks to this technique, which is known as functional MRI (fMRI), psychologists, sociologists, and economists can gain important insights into the human state of mind or decision-making processes based on their brain activity.
Magnetic resonance imaging has a very broad range of applications. Therefore, the method is used by various Technology Platforms. Four platforms that offer this technology in a range of research fields are presented on the following pages.
Magnetic Resonance Center of the University Hospital of Psychiatry Zurich (MRZ-PUK)
An Insight Into the Brain
The Magnetic Resonance Center of the University Hospital of Psychiatry Zurich specializes in researching neurobiological changes in the context of psychological diseases in people of all ages, from children and adolescents through to the elderly –for example, in the case of developmental disorders, depression, psychosis, addiction, and dementia. The goal is to better characterize individual disease processes and improve our understanding of the underlying pathological mechanisms – which is a key basis for personalized medicine.
Our services:
• Anatomic imaging
• Structural imaging (diffusion-weighted imaging)
• Functional imaging
• Spectroscopic imaging
• Advise on the design of MRI studies, data management, and record-keeping
• Provision of technical equipment for conducting studies
Location
University Hospital of Psychiatry Zurich Contact philipp.staempfli@bli.uzh.ch
www.mrz-puk-kjpd.uzh.ch
Center of the Department of Nuclear Medicine (PET/MR)
Advanced Molecular and Multimodal Imaging
PET/MR combines two imaging modalities into one device, allowing us to image the human body and its physiological processes at the very same time. Position emission tomography (PET) is a technique which uses radioactively labelled substances to observe their behaviour in the body like glucose consumption or colesterol deposits. By combining it with magnetic resonance imaging (MRI), this information can be combined with anatomic details and other functional data. This method is used for clinical applications in high-precision diagnostics as well as for various research studies – in the brain, the heart, and other regions of the body. The PET/MR technology combined with specific radiopharmaceuticals allows to trace basic physiological mechanisms in healthy humans or patients and increases our understanding leading to new developments for diagnostics and better treatments for diseases.
Our services:
• Multimodal imaging of all organs and the musculoskeletal system
• Simultaneous PET and MRI scans to combine anatomy with physiology
The Swiss Center for Musculoskeletal Imaging (SCMI) enables researchers to make detailed investigations of the inside of the human body with non-invasive systems. Due to its location on the Balgrist Campus, the SCMI is particularly suitable for research into the musculoskeletal system.
Our services:
• Access to radiological imaging –as an all-round service or on a self-service basis
• CT: system with best resolution and image quality at lowest radiation dose, in all parts of the body
• 7T MRI: highest resolution for dedicated research questions focusing on the head, knee, hand, spine, or other joints
• 3T MRI: premium system for tackling research questions in all parts of the body
• Ultrasound: High-end device, ideal for quantitative elastography
• Support with the planning and optimization of imaging protocols
• Close cooperation with the other Balgrist platforms
Preclinical Imaging Center (PIC)
Making the Inner Workings of Organisms Visible
The Preclinical Imaging Center works at the interface of engineering and biology. We use a wide range of cutting edge imaging methods to acquire anatomical, physiological, and molecular information from living tissues, in order to understand better their function. Our capabilities includ functional magnetic resonance imaging (fMRI), multispectral optoacoustic tomography (MSOT), fluorescence microscopy, and functional ultrasound. The Center also specializes in the development of new multi-modal instruments and methods for advanced data/image analysis with an aim to attain new insights into the intricate biology of diseases at multiple spatial and temporal scales. Some of the instruments invented and built in our center are unique and have no analogs worldwide.
Our services:
• Functional magnetic resonance imaging and MR microimaging (Bruker Biospec 94/30, Pharma Scan 70/16, cryogenically cooled transmit/receive radiofrequency coils)
• Multispectral optoacoustic tomography and microscopy
• Intravital fluorescence microscopy and macroscopy
• Animal housing for mice and rats for the time of study
Airborne Research Facility for the Earth System (ARES)
Research in a Plane: Observing Events on the Ground from Above
How is biodiversity changing in the Eurasian steppe? Are there unrecognized methane emitters in the energy infrastructure? These are just two examples of how adopting a new perspective can enable us to develop innovative approaches to many research questions.
We fly. And we are a highly experienced partner organization in many scientific fields. ARES takes highresolution images and scans of selected areas of the earth’s surface using complementary measurement techniques.
• The Imaging Spectrometer (AVIRIS-4) measures reflected sun rays in a spectral range much larger than can be perceived with the human eye. It also records ultraviolet and infrared radiation.
• The High-Precision Photogrammetric Camera (hpPC) creates a continuous and highly precise digital surface model of the area being surveyed using a combination (bundle adjustment) of partially overlapping images and the spatial position of the camera.
• The Light Detection And Ranging Sensor (LiDAR) emits laser pulses and receives their ‘echo.’ With this technology, information can be gathered on both the surface and the internal structures of ecosystems, such as forests.
The merged data make it possible to record changes in the earth’s surface, bodies of water, the use of the earth’s surface, vegetation density, and biodiversity. The data generated by ARES are stored in a data portal and are available to the public. The ARES team offers comprehensive advice on using the technology platform and data evaluation.
Who we are:
Infrastructure for airplane-based research into earth surface systems using state-of-the-art digital measurement tools.
Our services:
• Airborne earth observation
• Spectral ground control point collection
• Calibration and validation
• Data quality analysis
• Data processing and storage
Examples of three research projects:
Periods of drought affect the health of trees in the Swiss Mittelland region. ARES generates time series to analyze the long-term impact.
One of town planners’ goals is to reduce heat accumulation in urban concrete deserts. ARES sensors are used to classify the existing construction materials so that architects can record the city’s current status.
Algae are a risk factor for Swiss waters. ARES’s services can be used to measure algae levels and their local differences from the air.
Irchel
https://ares-observatory.ch
World Glacier Monitoring Service (WGMS)
Checking up on the Ice: The World Glacier Monitoring Service
Being particularly sensitive to global temperature changes, glaciers are referred to as clear indicators for climate change. The World Glacier Monitoring Service observes, measures, collects, and analyzes glacier changes, gathering important information on climate change impacts around the globe.
The World Glacier Monitoring Service (WGMS) collects, analyzes, and spreads data on glacier changes measured globally. Together with its international collaboration network, the WGMS provides data on changes in the mass, volume, area, and length of glaciers including statistical information on global ice coverage.
With these data from field and satellite observations, the WGMS provides important information on the state of our climate system and its changes through time. This forms a crucial basis for analyzing the possible effects of atmospheric warming and assists glaciologists and climate researchers with their work. The WGMS operates under the auspices of the International Science Council, the United Nations, and the World Meteorological Organization.
Who we are:
The WGMS is an international data service that collects, analyzes, and publishes data on glacier fluctuations.
Our services:
• Data from more than 275,000 glaciers in all regions of the world
• Standardized and quality-controlled observations of glacier changes (glacier fluctuations)
• Statistical information on the distribution of year-round surface ice (glacier inventories)
• Open access to all glacier data and information
• Support of users with the analysis of these data, for example for international climate reports, scientific publications, and media and outreach activities
• Maintenance of a local observers network in all countries involved in glacier monitoring
• Operation of the Global Terrestrial Network for Glaciers (GTN-G) in support of the United Nations Framework Convention on Climate Change (UNFCCC)
Examples of three research projects:
‘How are our glaciers doing?’ Based on the data collected on reference glaciers with long measurement series, the WGMS shows how much mass has been lost in the various glacier regions over time. Such analyses reveal, for example, that the ice in the European Alps is suffering particularly badly as a result of temperature increase.
‘How do glaciers contribute to the rise in global sea level?’ By combining field and satellite measurements, the WGMS estimates their contribution each year, revealing that glaciers are currently account for about 25% of the observed sea-level rise.
‘Which glaciers are the largest in the world?’ In a recently published study, in which the WGMS participated, the authors reveal the giants among the world’s glaciers and show that the answer to this seemingly simple question is much more complex than you might think.
Linguistic Research Infrastructure (LiRI)
Investigating Language with Innovative Methods and Cutting-Edge Technology
LiRI supports researchers investigating various aspects of language, from experimental studies in our stateof-the-art laboratory or with our field equipment to leveraging the latest language technology and machine learning.
The sate-of-the-art research laboratory located at the UZH Oerlikon Campus is the heart of LiRI. The lab features five recording booths that enable simultaneous communications between multiple study participants, while ensuring high-quality, isolated audio recordings. In addition, it houses two shielded booths for EEG experiments and another booth dedicated to audiometric or behavioral experiments. The facility is also equipped with an extensive array of measurement devices, including eye-trackers, fNIRS for language processing studies, ultrasound, and electromagnetic articulography for examining the mechanics of speech production.
We assist researchers in generating data, as well as in project-specific processing and long-term archiving. We offer a variety of evaluation and analysis options, including statistical analysis, text mining and data sorting for analysing texts, and the application of machine learning methods for automated analysis of language structures and content.
Who we are:
At the LiRI, a highly qualified and exceptionally wellequipped team supports researchers with projects focussing on the study of language, speech, and auditory processing.
Our services:
• Five recording booths, two EEG booths, one audiometric booth
• EEG, fNIRS, eyetracking, EMA, UTI, and more
• Field recording equipment and loan equipment
• Advice on all types of statistical analysis and modeling
• Experiment design, evaluation of statistical methods and data management
• Provision of media data via Swissdox@LiRI
• Provision of other analysis tools for linguistic corpora (text, sound, video) and other analysis tools such as data processing pipelines and annotation tools
• Conducting analyses, presenting and visualizing the results
• Tutorials, workshops, semester courses
Examples of three research projects:
Recent studies suggest that there is a connection between language processing and dementia risk. Researchers are following this trail with LiRI.
Why are sounds pronounced the way they are and not differently? A study of phonetics across languages and their implications for AI language processing.
How can political participation succeed? In online political discussions, a virtual moderator employs AI to generate new questions based on positions of actual participants.
Laboratory for Social and Neural Systems Research (SNS Lab)
Tracking Human Behavior With Neuroscience
Freud wasn’t the first to tell us that free will is actually rather ‘unfree’ and that our decisions are based mainly on complex biological and neural processes. The Laboratory for Social and Neural Systems Research (SNS Lab) investigates these processes – using imaging techniques and innovative methods.
As the centerpiece of the Zurich Center for Neuroeconomics (ZNE), the SNS Lab supports studies about the biological and neural mechanisms underlying our decision-making behavior. Researchers at the SNS Lab use innovative imaging technologies and combine them with non-invasive brain stimulation, neuropharmacology, and computational modeling.
With the offered technologies, it is possible to analyze which areas of the brain are active and which behavioral patterns occur in certain situations. Not only do these analyses clarify the neurological foundations of behaviors; they also allow conclusions to be drawn about learned values and social characteristics. In addition, it is possible to experimentally influence brain functions in the SNS Lab, enabling the simulation of emotions and research into brain capacity. In addition to experimental set-ups with individual test subjects, the SNS offers the possibility of investigating decisionmaking processes in the group laboratory with up to 16 people simultaneously.
Who we are:
The SNS Lab is an interdisciplinary laboratory that specializes in investigating the biological mechanisms underlying human decision-making behavior.
Our Services:
• Functional and structural magnetic resonance imaging (MRI)
• Electroencephalogram (EEG)
• Non-invasive brain stimulation
• Behavioral studies of groups with up to 16 members
Examples of three research projects:
How is stress associated with decision-making and brain functioning? At the SNS Lab, test subjects experiencing different levels of stress are offered various foods. The experiment shows that in stressful situations, we are more likely to choose a food based on its flavor than on its health value.
How are financial decisions associated with the parts of the brain that are responsible for the elementary processing of numbers? Targeted stimulation of these brain regions caused test subjects to shy away from financial risks.
To what extent can pharmacological interventions with neurotransmitters make it easier for people to take “stop decisions”? The results of a study on this question showed that groups with increased levels of noradrenaline or acetylcholine stopped using a limited resource earlier. This finding could lead to new therapeutic approaches to the treatment of conditions such as gambling addiction and obsessive-compulsive or anxiety disorders.
Swiss Art Research Infrastructure (SARI)
Connecting Data in the Humanities: Swiss Art Research Infrastructure
The computational analysis, interpretation and linking information about images and other visual sources lead to vital new insights on artworks and artists. It is therefore all the more important to make these data accessible to and usable for researchers. By analyzing, structuring and providing access to data, SARI aims to offer new research approaches in the humanities.
Whether in the field of art history or film studies, archeology or the history of architecture – the digitalization and publication of these data is pivotal for our cultural heritage. Therefore, the expansion of data-centered research, computational analysis of visual artifacts, and data linking play a crucial role in today’s humanities. Different contexts and mutual relationships become visible and allow new research questions to be explored. Such data-centered research creates new opportunities for the humanities.
Swiss Art Research Infrastructure (SARI) is a leading national research institution that provides access to existing research data, digitalized sources, and reference data. Through the application of international standards, SARI enables data to be produced in a globally readable format, datasets from different collections to be combined, published, and researched in a sustainable manner. Thus, SARI promotes global data accessibility for academia. It connects specific research and collection data in a digital research environment. This approach gives researchers easy access to large quantities of data from different sources and enables cross-disciplinary cooperation between academics.
Who we are:
SARI is a leading research infrastructure for datacentered research in the fields of cultural heritage and the humanities.
Our services:
• Developing tools for quantitative and qualitative data visualization and analysis in the area of cultural data including images, video and audio recordings
• Applying machine learning and artificial intelligence
• Development, hosting, and operating customized research environments
• Editing suites for vocabulary collections and thesauri
• Data curating, clean-up, and validation
• Matching and enriching of research data with existing sources
Examples of three research projects:
„Bilder der Schweiz online“ is a research platform that offers insights into historical depictions of Switzerland from various collections. SARI links these images and their context information, so that users can discover the collection from different perspectives und use artificial intelligence to search for visually similar objects.
The “Johannes Itten Linked Archive” knowledge platform contains an extensive bequest of the Swiss artist and art theorist Johannes Itten. Thanks to SARI’s data visualization, researchers can navigate through networks of people, locations, and objects and examine complex interconnections within the estate.
With “Sammlung digital” (the digital collection), SARI provides comprehensive access to the collection of the Stiftung für Kunst, Kultur und Geschichte (SKKG) and combines internal and external information. The platform invites both specialist audiences and the broader public to explore the collection and discover new things beyond what they were initially searching for.
Center for Digital Editions and Edition Analytics (ZDE)
Making Cultural Sources Accessible: Creating Digital Editions with the ZDE
Digital editions are a key means of making cultural sources accessible for research and society. Specialist disciplines such as history, philology, and law make digitally edited sources available online so that they can be searched and used for additional research projects. The ZDE helps them to do this.
The Center for Digital Editions and Edition Analytics (ZDE) is a central point of contact and coordination for all types of digital edition projects that are based at UZH. The center’s specializations are:
• Advice and coordination
We advise researchers on platforms and services for digital editions and promote cooperation. Data standards and interoperability are guiding principles. In addition, we inform interested parties about the latest requirements for project applications.
• Visibility of edition projects and networking
We ensure visibility for digital edition projects at UZH and open up opportunities for networking between digital research projects.
• Long-term archiving and access
We support digital edition projects in their search for suitable solutions for the long-term archiving of their data (for instance, in collaboration with the Swiss National Data and Service Center for the Humanities (DaSCH)). Together with partners from the field of digital humanities, we promote the scientific study and discussion of digital editions.
Who we are:
The ZDE is the central point of contact and coordination for digital edition projects
Our services:
• Support with project applications
• Advice on the use of suitable digital tools
• Coordination of requirements for long-term archiving
• Ensuring the visibility of digital edition projects
• Organization of networking services
• Advice and information on the implementation of the FAIR principles, including data management plans
Examples of three research projects:
The edition project “Johann Caspar Lavater Online Letter Edition” makes Lavater’s extensive correspondence accessible, thus providing a key foundation for researching the European knowledge and scholarly network of the 18th century. The ZDE provides support with communications, the use of the Transkribus transcription tool, and coordination with DaSCH and technical research partners.
The “Bullinger Digital” research project makes the extensive correspondence of Heinrich Bullinger digitally accessible. It uses, among other things, AI-based tools for machine transcription of handwritten sources. The ZDE supports the project with communications, coordination with partners for long-term archiving, and the implementation of the FAIR principles.
The archive of the French philologist Gaston Paris is scattered far and wide. It is currently being collated and made accessible online via a binational research project. The ZDE provides support with workflow, networking, and technical implementation.
Cytometry Facility (CF)
A Precise, Versatile and Fast Detection Method for Improving Our Understanding of Cellular Behavior
Flow cytometry is a modern method for analyzing the functions of cells. It has a wide range of applications to study the development and performance of cells or to investigate cellular mechanism. In addition, flow cytometry offers the potential to select a specific cell type out of a large population for further examination or clinical usage.
Bodies and tissues consist of different cell types. Flow cytometry can be used to identify and count, or to sort specific cells due to specific properties. Therefore, it is a crucial method for cell research in medicine, plant biology, ecology and others. In essence, antibodies are used to identify cellular components of interest. They are labelled in standard applications with a dye which can be excited by a laser. The emitted light can be detected, and depending on the color of the dye the specificities of the cell can be analyzed or it can be sorted to groups of cells with the same dye pattern in flow cytometers. More recently, other detection methods have been introduced to label antibodies for specific applications.
Who we are:
The Cytometry Facility offers access to state-of-theart flow cytometry infrastructure and technologies. It offers operator-performed services, supports data analysis and advises the project design.
Our services:
• Spectral, multi parameter flow cytometry analysis
• High-speed cell sorting
• Imaging flow cytometry and sorting
• Small particle flow cytometry
• Data analysis support
Examples of three research projects:
To get an overview on the COVID-19 burden in the city of Zurich, waste water samples were explored for their viral composition. Based on the proportion of COVID-19 viruses in the sample, researchers could draw conclusions about the disease burden in the city.
Blood or bone marrow samples of a patient are analyzed for up to 30 tumor markers simultaneously. Thereafter the specific treatment can be designed.
A contamination cluster is identified in tap water or another water source by screening for known components of bacteria or other cellular contaminations.
Location
• Irchel Campus
• Schlieren Campus
• University Hospital Zurich
• Lengg Campus
Contact info@cytometry.uzh.ch
www.cytometry.uzh.ch
Electrophysiology Facility (e-phac)
Where There is a Cell, There is Current
Electrically charged molecules and ions are distributed unevenly between the inside and outside of cells, creating electrical fields. Using these electrical fields, signals are sent across cells and organs. Electrophysiological techniques allow the measurement of these signals enabling their interpretation and manipulation in health and disease.
Cells in humans and other multicellular organisms have evolved ingenious ways to communicate with each other including hormones and electrical impulses. Small changes in ion concentrations create electrical signals across cells. Disruptions in these signals are characteristic of grave pathological conditions such as Alzheimer’s disease, cardiac infarction, and cancer. In the Electrophysiology Facility, we specialize in measuring the electrical communication of these cells across a multitude of different cell types and tissues. Notably, we have expertise in measuring human and animal neurons, heart muscle cells, and tumor cells. Among other techniques, we use thin glass pipettes containing an electrode to measure currents across cell membranes in the magnitude of picoamperes (a trillionth of an ampere). Furthermore, we establish and develop these techniques in automated highthroughput setups. With our expertise we can combine electrophysiology with microscopy allowing a comprehensive assessment of cell function.
Who we are:
The Electrophysiology Facility supports researchers in the field of in-vitro electrophysiology.
Our services:
• Data collection and analysis by means of:
- Manual patch clamping (also in combination with microscopy)
- High-throughput automated patch clamping
- Two-electrode voltage clamping
- High density microelectrode arrays
• Training in electrophysiological techniques
Examples of three research projects:
The facility can test the impact of novel drugs on ion channels in cardiac cells to evaluate potential side effects on heart physiology.
Electrostimulation is one of the most promising methods for healing neural injuries, for example after a spinal cord injury. The electrical conductivity of nerve cells indicates the efficacy of new approaches in clinical treatments.
A therapy can be developed by culturing human neurons derived from skin biopsies of patients diagnosed with Autism Spectrum Disorder and describing how their electrophysiological properties differ from those from healthy controls.
Viral Vector Facility (VVF)
Minor Cause – Major Effect: Controlling Organisms with the Help of Viruses
The Viral Vector Facility orchestrates the alteration of cellular functions through delivery of new genetic information provided by modified viruses. This method is utilized in both basic and applied research, including the scientific areas of vaccines and gene therapy, for gaining new insights into healthy organisms and developing novel therapies.
Complex organisms rely on a well-coordinated organ system for their survival. Organs are composed of tissues whose function is governed by individual cells. Hence, it is of great interest to precisely alter the operation of cells and observe the associated effects –both at the level of the cells themselves and in the organism as a whole.
At the Viral Vector Facility (VVF), researchers can manipulate cells in a targeted manner by taking advantage of the natural ability of viruses to ‘smuggle’ their genetic material into cells. The VVF modifies and replaces the genetic material found in viruses and then provides the necessary environment for the replication of these altered viruses, which are known as ‘viral vectors.’ Unlike viruses, viral vectors are unable to reproduce, but retain the ability of viruses to carry genetic information. Researchers use viral vectors to deliver rationally composed genetic information and study its effects on cells, organs, and – subsequently – whole organisms.
Viral vectors are utilized in both preclinical and clinical trials and applications. The VVF offers ready-to-use viral vectors for routine applications, but it also produces customized viral vectors for specific requirements.
Who we are:
The VVF produces viral vectors as a tool for transferring genetic information and studying its effects.
Our services:
• Production of customized AAV, lentiviral and ү-retroviral vectors
• Provision of ready-to-use AAV vectors (repository)
• Cloning of customized plasmids, including AAV and lentiviral plasmids
• Amplification of any plasmids
• Amplification of plasmids on a large scale (up to 100 mg)
Examples of three research projects:
The facility can produce viral vectors that encode a novel kind of sensor that is used to track the release of neuropeptides in the brain in real time in order to clarify their action.
The facility can produce viral vectors that make it possible to control neural activity and investigate the resulting effects on pain perception.
The facility can produce viral vectors that instruct liver cells in mice to release fluorescent proteins, thus making it possible to study changes in the blood flow over several months.
Location Irchel Campus Contact info@vvf.uzh.ch
www.vvf.uzh.ch/en.html
Nanobody Service Facility (NSF)
The Nanobody Service Facility uses the immune system of alpacas to produce nanobodies. These tiny antibody fragments have a simpler structure than conventional antibodies and occur in all camelid species.
Antibodies are proteins produced by immune cells as a reaction to foreign substances, which are known as antigens. In the human body, antibodies serve to fight off diseases, but in research they are used for a wide range of applications – for example to mark antigens (e.g. to observe COVID-19 particles), to change their function, or to deactivate them.
Conventional antibodies are complicated molecules that are relatively difficult to handle and modify for research purposes. Nanobodies, by contrast, are easier to adapt to specific requirements as they are significantly smaller and simpler but have the same effect. They can also recognize hidden structures and their bonding capacity can easily be altered by means of genetic engineering, for example. Furthermore, not only are they straightforward to produce, clean, and analyze in the lab; they are also easier to store, transport, and replicate.
The Nanobody Service Facility produces individual nanobodies for research projects and helps project participants make and optimize nanobodies themselves.
Who we are:
The NSF produces camelid antibody fragments (nanobodies) for the Life Science Community.
Our services:
• Alpaca hyperimmune serum with polyclonal antibodies
• Lymphocytes after immunization
• Phagemid and phage nanobody libraries
• ELISA-screened positive bacterial clones
• Amino acid sequences of the target-specific nanobody and the plasmids coding it
Examples of three research projects:
Nanobodies can be broadly used in biomedical analyses –from immunohistochemistry to live imaging to the determination of protein structures.
Nanobodies are an ideal tool for functional studies as they often inhibit protein functions (enzymes, transport proteins, signaling pathways), or to study protein-protein interactions).
Nanobodies are also ideal for the development of diagnostic tests – including non-invasive cancer imaging.
Functional Genomics Center Zurich (FGCZ)
Functional Genomics: Quantitative Molecular Analytics and Bioinformatics
The Functional Genomics Center Zurich (FGCZ) supports research projects in the field of life sciences and offers experimental analytics and data analysis services. Its focus is on the complex functions of molecules – such as nucleic acids, proteins, metabolites, and lipids – and their interaction in cells, tissue, and organisms.
Our specialization is the study of biological systems on all scales. Mass spectrometry analyses of tissue samples for individual proteins and their chemical modifications are just as much part of our work as the simultaneous sequencing of millions of different DNA and RNA molecules from a single isolated cell.
Projects carried out in the FGCZ include:
• Analyzing the reactions of individual cells, specific tissues, or entire organs to changed environmental or metabolic conditions, such as those that occur during illnesses.
• Characterizing processes that occur during the genesis and growth of organisms – from bacteria through to humans.
• Investigating entire ecosystems – e.g. identifying all microorganisms in the environmental samples or the human intestine.
Our services include providing advice on, planning, and carrying out projects and analyses in the field of omics research. In the process, we support scientists with experimental analyses for data generation, data processing, and bioinformatics-based interpretation of the results. As part of projects and on specialized courses, junior researchers are trained in the concepts and methods used, enabling them to carry out complex projects and correctly interpret the data generated.
Who we are:
The FGCZ is a research facility and educational institution of the University of Zurich and ETH Zurich specializing in molecular analytics and omics research.
Our services:
• Genomic, epigenomic, and transcriptomic analayses, including single cell and spatial analyses
• Proteomic, protein modification, and interaction analyses
• Metabolite and lipid analysis and quantification
• Bioinformatics support and services in all areas
• Training for access to high-end instruments, multi-day practical courses in all omics disciplines, and applied bioinformatics courses
• Rent-an-expert options
Examples of three research projects:
To develop individual treatment options for patients, genes or proteins can be identified that provide information early on about how a cancer will develop.
To promote environmentally friendly and sustainable agriculture, the cultivation of fruit and grain varieties can be controlled by molecular characterization.
Microorganisms are investigated to understand their interconnections in their environment such as the human intestine or in an ecosystem. The gained information can be used to improve medical therapies or biotechnological processes.
Nuclear Magnetic Resonance (NMR) Spectroscopy
Very Powerful and Versatile Structural Analysis
NMR is one of the most versatile chemical methods. The two Zurich researchers Richard Ernst and Kurt Wüthrich were instrumental in advancing the method, for which they were awarded the Nobel Prize in Chemistry. One of the great strenghts of NMR is that it provides a highly precise analysis of chemical structures, which paves the way for important findings in chemical compound analysis and structural biology.
The principle is similar to that of magnetic resonance imaging: in NMR spectroscopy, atomic nuclei are exposed to a strong magnetic field. From interactions with the magnetic field, conclusions can be drawn about the chemical environment of the atomic nucleus and the type of and distance to neighboring atoms. In this way, simple molecules can be analyzed to determine their chemical composition and purity. In contrast to the more common MRI, this method can also detect and analyze other elements (carbon, nitrogen, phosphorus, etc.) in addition to hydrogen. It is also used to analyze the structure and dynamics of biopolymers (e.g. proteins and nucleic acids) but is not suitable for investigating entire organisms due to its focus on molecules. NMR technology also makes it possible to observe chemical reactions and other molecular changes in a time-resolved manner.
The NMR facility has extensive technical expertise in a wide range of NMR applications used in modern analytical chemistry and biochemistry.
Who we are:
The NMR facility supports researchers in conducting chemical analyses and analyzing structure-related questions of chemical compounds and biomolecules.
Our services:
• Structure elucidation and purity control of small molecules
• Reaction control and kinetics experiments at variable temperature (VT)
• Diffusion-selected spectroscopy
• Biomolecular NMR (structure and dynamics)
• Protein-ligand interactions (screening)
• Solid-state NMR (CP-MAS)
Examples of three research projects:
The NMR spectroscopy can investigate the reaction of kinetics using fluorine NMR. Chemical reactions are tracked with high sensitivity and time resolution. This makes it possible, for example, to track the formation of intermediate products in order to optimize reactions.
The chemical structure of isolated natural substances can be elucidated by using multidimensional NMR spectroscopy for their precise identification, e.g. whether they are steroids or alkaloids.
The NMR spectroscopy offers structure-based development of antibiotics: In one such project, the structures of the antibiotics were determined in the receptor-bound state, thus enabling the optimization of their interactions with the receptors, improving their medical effects and understanding their mode of action.
Research that gets People Moving: The Swiss Center for Movement Analysis
Reduced mobility is a widespread problem that often restricts people’s ability to go about their daily activities. The Swiss Center for Movement Analysis (SCMA) offers a highly specialized platform for the quantitative analysis of movements. We measure treatment success and quantify prevention methods for sport and rehabilitation.
The SCMA is a research platform that specializes in high-precision movement analysis. An objective quantification of movements is crucial for carefully studying the patient benefit of therapeutic interventions.
The SCMA provides instruments and methods for quantifying different facets of movement. These include analyses of three-dimensional movement (kinematics) and measurements of ground reaction forces (kinetics). Mobile measurements of muscle activity (electromyography) and metabolic measurements during physical activity (spiroergometry) are also performed. The SCMA also has various systems that support movement analysis and training (e.g. Lokomat, FLOAT).
One of the SCMA’s priorities is to replicate movement sequences in realistic scenarios – e.g. using a treadmill that is integrated into a virtual reality environment (GRAIL). GRAIL is ideal for challenging gait situations (e.g. gait perturbations) – in both patients with moderate movement limitations and elite athletes.
The SCMA is constantly developing new technologies in order to drive progress in the field of movement analysis. Examples include instrumented crutches and wheeled walkers that make it possible to analyze compensatory forces and a modifiable step-ramp construction for performing movement analyses.
Who we are:
The SCMA is a modern research facility that specializes in quantitative clinical movement analysis.
Our services:
• Use of state-of-the-art movement analysis technologies: from 3D motion capture systems to a variety of force plates to split-belt treadmills
• Support with the preparation, performance, and analysis of study measurements in the area of movement analysis
• Mobile devices for measuring the energy cost of various movements
• Multidirectional, adaptive body weight support systems (FLOAT)
• Robot-assisted walking for people with severe gait disorders (Lokomat)
• Treadmill-based real-time feedback system with virtual reality (GRAIL)
• Ground projection system for advanced and interactive gait assessment
• Instrumented walking aids for measuring compensatory forces
• Instrumented step-ramp construction for assessing everyday movement tasks
• Use of the infrastructure as “qualified users” or as an “all-inclusive” solution encompassing the drafting/development of study protocols, performance of measurements, data analysis, etc.
• Close cooperation with the other Balgrist platforms
Examples of three research projects:
The SCMA can assess the impact of various climbing techniques on the stress load experienced by the pulley in sport climbers using high-resolution kinematic analysis and instrumented handles.
The SCMA can examine the efficacy of shoulder prosthesis on arm movements performed in daily life activities using a specialized kinematic model for upper extremity movements.
The SCMA can validate an AI system for video-based movement analysis with state-of-the-art kinematic motion capture. The AI system will be used to draw up individually optimized, home-based physiotherapy programs and to assess the quality of the performed movements in the future.
Swiss Center for Musculoskeletal Biobanking (SCMB)
Collection, Storage, Analysis: The Certified Biobank Platform for Research
Collecting and storing of precious tissue and fluid samples over extended periods, so that they may be analyzed and compared in the future, are important prerequisites in the efforts to prevent or cure diseases.
The Swiss Center for Musculoskeletal Biobanking (SCMB) is an open biobank certified by the national Swiss Biobanking Platform that enables researchers to store tissue and fluid biosamples and analyze their quality for storage.
At the heart of the SCMB is its state-of-the-art, automated cryo-infrastructure, which makes it possible to store and conserve tissue samples while maintaining cell vitality. Further resources at the center are also available to researchers, including electronically bookable laboratory workstations, a cell sorting service and fluorescence microscopy services, operated together with the University of Zurich (UZH).
The SCMB supports research projects involving biobanking. In the areas of bone and joint biology in particular, the center’s proven expertise is a major asset.
Who we are:
The SCMB is an open, certified biobank platform for storing and analyzing tissue and fluid samples.
Our services:
• Secure long-term storage of clinical samples
• Precise sample processing and documentation with standard operating procedures
• Working methods in accordance with ISO 20387 guidelines
• Comprehensive sample tracking and temperature documentation
• Fast and secure dispatch
Examples of three research projects:
People with acute spinal cord injuries often suffer from incontinence as a complication of their injury. To investigate the success of various therapeutic approaches in a multicenter study, bladder tissue, blood, urine, and stool samples are stored for examination.
For research into a rare bone cancer disease, a researcher is able to access blood and cancer tissue samples that were taken from an affected patient years ago.
At the SCMB, the comparison of biochemical features of blood cells in a rare blood clotting disease which results in prominent joint degeneration from patient’s samples collected over many years is possible.
A Real Milestone: Research with Induced Pluripotent Stem Cells
Working with induced pluripotent stem cells (iPS cells) provides many benefits. They are derived from adult cells, which eliminates ethical concerns about the use of embryonic stem cells. In addition, iPS cells can differentiate into various cell types, making them ideal for use in cell therapy and research.
The cells in our body differ depending on the tissue they belong to. Nevertheless, they all originate from stem cells with the potential to develop into different types of cells. Thanks to the induced pluripotent stem cell (iPSC) technology, launched in 2006, this development process can be reversed. In other words, stem cells can be generated from cells that have already differentiated. This discovery has opened up many undreamt-of possibilities in regenerative medicine and disease modeling, but also in drug research.
iPSCore supports both basic and translational research in the field of iPSC technology. The iPSC Core Facility masters all processes, ranging from the reprogramming of primary somatic cells to the analysis of differentiated cell types of specific interest. The selection of the services is designed in such a way as to offer optimal solutions for certain cell types.
Who we are:
The iPSCore facility performs basic and translational research and provides services in the field of iPSC technology.
Our services:
• Biobanking of cells
• Reprogramming of adult cells
• Quality control of iPS cells
• Differentiation of iPS cells into various cell types: cardiomyocytes, macrophages, neurons, etc.
• Gene editing of iPS cells
Examples of three research projects:
The iPSC technology can be used to generate brain cells for Alzheimer’s research without having to take neurons from a person.
Disease processes can be studied in culture dishes more effectively on the basis of a few iPSC cells from patients. They are multiplied in cell culture and re-differentiated in cells that are very similar to the disordered tissue. In this way, the person specific effect of drugs can be tested prior to their application.
Patients receive cell therapies that are generated from their own cells using iPSC technology. This is a big step towards personalized medicine.
Regenerative Medicine Technologies Platform (RMTP)
Production for Clinical Trials: The Regenerative Medicine Technologies Platform
Researching and developing regenerative medical therapies is a challenging task, and obtaining the necessary regulatory approvals is demanding. The RMTP experts are certified and reliably manufacture products in clinical quality, that meet all certifications for clinical studies fully.
Translating insights from biomedical research into clinical applications is a strictly regulated process. One requirement is to conduct clinical trials with the developed research products under defined and certified conditions that are subject to very strict legal criteria (Good Manufacturing Practice (GMP)). The Regenerative Medicine Technologies Platform is a certified, state-of-the-art technology and scientific platform that enables and supports the production of medicinal products in GMP quality.
The RMTP experts’ goal is to assist research project leaders with the efficient translation of basic biomedical research into applied regenerative therapies and accelerate the entry of innovative treatments into clinical trials. In addition, product development processes have been established in alignment with the ISO 13485 standard to support and accelerate the growing number of medical device projects.
With its expertise, the platform paves the way for transforming innovation into medical applications and founding a start-up company.
Who we are:
The RMTP is a certified GMP platform that supports researchers with the manufacture of clinical-quality medical products.
Our services:
• GMP-production on a total footprint of 800 m2 –with grade A, B, C, D, and E clean rooms
• Qualified equipment for the production of medicines and cell therapies
• Swissmedic manufacturing and distribution license
• Certified quality management system and quality management processes according to ISO 13485 for the development of medical products
• Provider for initial and continuous training of the relevant guidelines
• Analytical batch release and in-process control of drugs and cell products
• Supplier qualification
Examples of three research projects:
Researchers have developed a method to grow personalized skin grafts from small patient skin samples. The produced skin graft can be used to treat large areas of damaged skin, for example by a burn injury. With the support of RMTP, clinical samples have been grown in the certified laboratories and subsequent submissions for regulatory approval of the skin graft production have been successful.
A new therapeutic approach promises young patients with congenital heart defects a cure by transplanting a heart vessel grown from their own tissue that continues to grow with them after its insertion. RMTP supports the researchers in translating such scientific visions into a clinical application. It helps to design and develop the production process under national and international quality requirements.
A new, minimally invasive therapeutic approach for the treatment of stress incontinence aims to implant patient derived muscle cells into the sphincter area of the bladder. Thanks to RMTP’s support with its certified laboratories and quality management system, the researchers learn about the necessary process improvements needed to fulfill the requirements of clinical approval.
Laboratory Animal Services Center (LASC)
For Medical Progress: The Laboratory Animal Services Center
Despite modern computer models and cell cultures, animal experiments remain unavoidable and play an indispensable role in research about complex biological processes and the development of new medicines and treatments. The LASC is the first port of call for biomedical research in laboratory animals. In addition to keeping and breeding laboratory rodents, the center is also committed to the implementation and further development of the 3R principles for ethically responsible animal husbandry.
The Laboratory Animal Services Center (LASC) is the central point of contact for biomedical research with laboratory animals and operates the infrastructure required for this. It has several sites in the Zurich and Schlieren area and supports UZH researchers by giving advice, keeping and breeding laboratory animals, and providing subject-specific services and the infrastructure required for research projects.
The focus lies on ethically responsible animal husbandry by keeping with the 3R concept and in compliance with all cantonal and federal legal requirements and guidelines. Furthermore, the LASC ensures adherence to high hygiene standards when it comes to keeping animals, in order to avoid research results being impacted by pathogens.
To be able to guarantee these high-quality standards, the LASC offers training courses for researchers in special techniques, runs its own training program for animal carers, and operates an animal administration system that it has developed itself.
Who we are:
The LASC is the central point of contact for biomedical research with laboratory animals.
Our services:
• Provision of high-quality infrastructure for animal husbandry and experiments at various hygiene levels
• Animal-related services (biopsies, mating, health exams, etc.)
• Biosafety labs at levels BSL2 and BSL3
• Centrally coordinated animal procurement, animal imports and exports
• Training of researchers in special techniques
Examples of three research projects:
Infection tests are conducted on rodents in biosafety labs in order to better understand the ill-making mechanisms of the pathogens and develop effective treatments.
To be able to investigate the effect of different medication treatments, researchers require all mice that are part of the study to be kept in the same conditions in terms of feeding, lighting, ventilation, etc., and that the animals’ stress level is as low as possible. This is ensured by the care and infrastructure of the LASC, and makes the study result reliable and scientifically reproducible.
Regulations of animal experiments are very strict. The LASC helps researchers to apply for and implement animal experiment approvals correctly.
Zurich Integrative Rodent Physiology (ZIRP)
ZIRP: State-of-the-Art Techniques for Responsible and Valid Animal Experiments
ZIRP offers expertise and state-of-the-art techniques for performing animal experiments on rodents – from imaging and laboratory analysis to measurements of physiological, metabolic or behavioral parameters and microsurgery services. The ZIRP suppports researchers during both the planning and implementation stages of studies.
Animal experiments are currently indispensable, both for the development of new treatments and in fundamental research. Rodents are most frequently used as experimental animals, and all techniques have to be adapted to their size and specific characteristics. ZIRP provides expertise and state-of-the-art infrastructure for conducting animal experiments with rodents. Its services include an imaging platform (microCT, MRI, optical imaging, ultrasound), a laboratory analysis platform, microsurgery services, and various devices for analyzing physiological and metabolic parameters (calorimetry, plethysmography, telemetry, video monitoring).
ZIRP already supports support researchers during the study planning stage, helping them choose appropriate methods and write SOPs, score sheets, and animal experiment applications. During the implementation of the study, certain parts of the experiment or techniques (e.g. blood sampling, injections, operations) can be performed by ZIRP staff.
ZIRP conducts its own studies for improving experimental conditions and offers practical training courses in small groups on the methods and techniques it offers.
Who we are:
ZIRP offers expertise and state-of-the-art infrastructure for carrying out animal experiments with rodents.
Our services:
• Advice on the planning and organization of animal experiments
• Individual training on experimental procedures
• Species-specific medical expertise and methodology
• Measurement of metabolic parameters (metabolic cages, calorimetry)
• Measurement of physiological parameters (telemetry)
• Laboratory analysis platform
• In-vivo imaging platform
• Surgical services
Examples of three research projects:
A novel therapy is used in a rat with a tumor. ZIRP’s laboratory equipment is specifically adapted to the animal, enabling precise observation of the treatment success.
A new procedure promises to restore liver function after surgical removal of part of the liver. After some successful in-vitro experiments, the procedure is tested in a mouse.
To establish the ideal housing conditions for rodents, various promising options are tried out and the mice are examined to assess their wellbeing.
https://www.zirp.uzh.ch/en.html
Musculoskeletal Research Unit (MSRU) Researching what gets Us Moving: The Musculoskeletal
Research Unit
From back problems to osteoarthritis, orthopedic problems affect millions of people around the world and is an important field of medicine. The Musculoskeletal Research Unit conducts research projects with the goal to investigate better treatment options for orthopedic and soft tissue diseases.
The MSRU was founded 30 years ago as part of the Vetsuisse Faculty for the purpose of conducting experimental research into new treatment options for musculoskeletal problems.
Orthopedic studies are carried out at the MSRU on a variety of tissues, for instance on the bones, tendons, ligaments, and cartilage. Other specializations relate to scientific questions in the fields of wound healing, vascular diseases, and skin tumors. New forms of treatment are developed, implants tested, and the safety and efficacy of innovative surgical methods assessed.
To this end, the MSRU operates a research facility that has been awarded the Good Laboratory Practice (GLP) certificate and specializes in developing animal models and conducting preclinical trials. Made up of veterinarians and bioengineers, the MSRU team possesses extensive veterinary and scientific expertise –in implementing animal studies, analyzing tissue samples, and evaluating the biocompatibility of novel biomaterials, such as biodegradable implants for the surgical treatment of bone fractures.
Who we are:
The Musculoskeletal Research Unit (MSRU) supports scientists in the implementation of preclinical experimental animal studies.
Our services:
• Providing Advice on and planning of preclinical studies in living animals, draw up animal experiment applications
• Realization of studies, monitoring of the animals, anesthesia, operations, follow-up care, obtainment of samples
• Paraffin and plastic (PMMA) embedding of sample materials
• Evaluation of histological sections
• Execution of studies in accordance with GLP standards
Examples of three research projects:
Aneurysms with subsequent brain hemorrhage have severe consequences for patients. Gender-specific differences in the structure of aneurysms were found in a research project. To achieve this, an aneurysm was created microsurgically in rats of both genders and the structure of the blood clot that developed was then examined for gender-specific differences.
Delayed bone healing is a major challenge when it comes to recovering from fractures. Two sheep models with standardized slow bone fracture healing were treated with a novel technology at the MSRU. The combination of electric and magnetic field therapy (CEMF) indeed lead to an enhancement in bone recovery.
In order to treat disc degeneration, spinal deformation, narrowing of the spinal canal, and spinal fractures, the vertebral joints are fixated surgically. Existing screws often come loose too early, and the patients have to be operated once again. Using a novel pedicle screw technology, a stabilization of the screw anchoring was successfully tested in sheep spines at the MSRU.
Center for Preclinical Development (CPD)
For Medical Progress: The Center for Preclinical Development
Before new surgical methods or implants can be used in humans, they must be tested in practice. The Center for Preclinical Development is a leading facility for experimental surgery and the testing of medical technology products. It offers a number of testing opportunities and actively promotes the continuing development of medicine.
The Center for Preclinical Development is a technology platform specialized in experimental research in the fields of medical technology and surgery that is unique in Europe. The Center runs various operating theaters, evaluates applications for ethical approvals, and supports researchers with experiments in small and large animals.
The benefit for researchers is that they can implement innovative surgical techniques under expert, responsible supervision, establish new animal models for investigating diseases, and test newly developed medical products in vivo.
Alongside a “hybrid” operating theater, the Center for Preclinical Development also offers additional conventional operating theaters and imaging equipment (MRI/CT) for large animals and microsurgery operating tables and MRI and CT scanners for small animals. Various laboratories, including a histology laboratory, and device pools are also available. The center′s interdisciplinary team of experts is available to all interested researchers for the planning, authorization, and implementation of animal experiments.
Who we are:
The Center for Preclinical Development is a technology. platform for translational research in medical products and surgery.
Our services:
• Experimental operating facilities for large animals and microsurgery facilities for rodents
• Hybrid operating theater for minimally invasive procedures in which surgeons can use imaging to guide the surgery
• MRI and CT scanners for large and small animals with supervision by a team of physicists
• Histology services
Examples of three research projects:
To reduce the risks in heart surgery, a minimally invasive catheter method for heart valve replacement is developed and tested in pigs.
A new active ingredient in a plaster is developed to prevent premature delivery after surgical procedures during pregnancy. To test its suitability, the ingredient is evaluated in a sheep.
A new liver regeneration process is tested in pigs with the ultimate objective of increasing the number of transplantable human organs.
AgroVet-Strickhof (AVS)
AgroVet-Strickhof: The Technology Platform for Scientists in the Farm Animal and Veterinarian Sector
AgroVet-Strickhof, a cooperation between the University of Zurich, ETH Zurich, and the Agricultural Center of Competence Strickhof, offers a platform to conduct and teach future-oriented research in the field of farm animal husbandry. Its activities include both fundamental and applied research.
Thanks to its interdisciplinary focus, AgroVet-Strickhof offers numerous possibilities for research in veterinary and farm animal sciences. The topics range from animal nutrition and husbandry to animal breeding and genetics to smart farming. Further aspects include animal health and the prevention of production-related diseases. The other strategic research principles cover security of food supply and food safety.
AgroVet-Strickhof has four sites at which different animal species are held for various forms of usage – in valley locations in Lindau and Wülflingen and at higher altitudes for pre-alpine and alpine farming. Students of agronomy and veterinary science are trained at all four sites.
Who we are:
The AgroVet-Strickhof is a platform for research and education in the areas of veterinary and livestock sciences. It provides the infrastructure for education and research in relation to dairy cows, beef cattle, calves, sheep, pigs, horses, poultry, and other farm animals.
Our services:
• Modern stables for dairy cows, growing cattle, mother cows, poultry, sheep, pigs, and horses for education and research
• Metabolism center with respiration chambers to measure CO2 and methane emissions and oxygen consumption and analyze the emissions of ammonia and nitrous oxide under standardized conditions
• A total of 12 respiration chambers in various sizes (small, medium, large) for all farm animal sizes
• Infrastructure for in-vitro rumen simulation techniques (RUSITEC, Hohenheim Gas Test)
• Modern laboratory infrastructure for the analysis of feed and food, tissue and blood samples, rumen fluid and excretions
• Forum with demonstration hall and training rooms
• Access to all infrastructures for all cooperation partners (University of Zurich, ETH Zurich, Strickhof) and for external parties
Examples of three research projects:
Different feed components and diets are examined in order to find strategies to reduce the methane emissions generated by ruminants.
Bone changes in pigs are analyzed in order to early detect their relation to the development of lameness.
Research is conducted in order to find alternative protein sources to soy in rations for poultry and their consequences for profitability and egg quality is examined.
Location
• Lindau (ZH)
• Wülflingen (ZH)
• Früebüel (ZG)
• Bergün (GR)
Contact info@agrovet-strickhof.ch
https://www.agrovet-strickhof.ch/en
Vetsuisse Clinical Laboratory (VCL)
At the Interface of Science: Clinical-Pathological Examinations of Experimental and Study Animals
Clinical-pathological examinations of laboratory animals are a specialization of the clinical pathologists working at the Clinical Laboratory, which is part of the Veterinary Teaching Hospital of the University of Zurich. The Laboratory’s objective is to support biomedical research and to be a reliable partner for preclinical toxicity and safety evaluations.
The Clinical Laboratory at the Veterinary Teaching Hospital of the University of Zurich is a multivalent laboratory that specializes in the examination of animal samples. Knowledge and understanding of species-specific features in the analysis and interpretation of hematological, clinical-chemical, and cytological examinations of mice, rats, primates, and other experimental animals are part of the Clinical Laboratory’s specialist field. The Laboratory analyzes around 30,000 samples per year, enabling the staff to accumulate extensive experience with a wide range of laboratory animals.
The Laboratory supports researchers carrying out projects inside and outside UZH with its expertise in hematology, cytology, clinical chemistry, and coagulation analysis. The Laboratory also offers special analyses, such as testing for acute-phase proteins. The certified specialists advise project leaders and young researchers, particularly in the area of pre-analytics. In addition, the Laboratory acts as expert partner for data analysis and interpretation.
Who we are:
The Vetsuisse Clinical Laboratory is the laboratory of the Veterinary Teaching Hospital of the University of Zurich.
Our services:
• Advice on pre-analytics, analytics, data analysis, and interpretation
• Clinical-pathological analyses for all types of laboratory animals (mice, rats, fish, etc.), pets, and farm, zoo, and wild animals
• Hematology (blood examinations) and cytology of bone marrow, puncture fluid, bodily fluids
• Clinical chemistry, clotting and urine analysis
• Hormone analysis and various immunoassays
• Good laboratory practice (GLP) studies on request
Examples of three research projects:
A novel gene therapy study for animals was conducted on blood and bone marrow samples in various animal species. The toxicity (harmfulness to cells) of the treatment is evaluated.
It is well known that vitamin D increases the growth performance of trouts. However, there was no consensus about possible side effects of vitamin D doses. A study inferred that the vitamin D did not impact the relevant hematological and clinical/chemical parameters, thereby excluding any side effects of food supplement with vitamin D.
As part of UZH’s One Health Initiative, it was demonstrated that SARS-CoV-2 can be transmitted from people to livestock and pets.
Science IT (S3IT)
For Computational Research: Our Science IT Center of Expertise
Whether it be AI and machine learning, the development of scientific software and research platforms or the processing of large quantities of data, Science IT experts are the point of contact for researchers who would like to use state-of-the-art IT for their projects.
Science IT’s expertise is in the areas of scientific computing, data science, and digital transformation. The center’s experts also advise scientists on a range of topics, including:
• Best use of the available research IT infrastructure
• Strategies for performing big calculations
• Optimization of scientific code
• Suitable software and tools to solve computational challenges
• IT platforms for research data storage and processing
• IT-related aspects in project funding applications
Researchers can directly access UZH’s IT infrastructure via Science IT. The center’s experts also help researchers to gain access to storage for their scientific workflow – for instance via the ScienceCloud, the ScienceCluster or via access to high performance computing at the Swiss National Supercomputing Centre. In addittion, the experts advise project leaders on IT aspects of complex research projects – such as the creation of scalable computer programs and the development of scientific software.
Who we are:
Science IT is UZH’s center of expertise for scientific computing, data science, and digital transformation.
Our services:
• Targeted advice on IT aspects of research projects
• Scientific software development
• Code optimization and parallelization
• Machine learning and AI
• Research data visualization and management
• Development of research platforms
• Access to multiple state-of-the-art computing services (e.g. ScienceCloud)
Examples of three research projects:
A researcher is evaluating data on user behavior from several million TV viewers that contains hundreds of variables. Processing the data is beyond the computing power of normal computers, so Science IT gives the researcher access to a purpose-built high-performance computing system and supports her in using it.
A researcher plans to build a chatbot based on a large language model that can answer questions on his area of research and summarize topics. To do this, open-source solutions are to be utilized on a UZH server. Science IT configures the required infrastructure, installs and configures the software, and optimizes the system for use in the context of the desired research field.
A research group would like to evaluate several thousand microscope images. Every individual image is to be analyzed according to a predefined process with various software applications and parameters. The Science IT experts implement a data processing workflow that enables the automated analysis of all images.
Technical Glassblowing (TGB)
Glass-Clear Advantages: Using One of the Oldest Materials for Research
Glass isn’t just shape-retaining, transparent, heat and chemical resistant and electrically insulating, it can also be put to a cost-efficient and targeted use in many scientific fields – for example chemistry, physics, medicine, and biology.
Glass is a highly versatile material. It is resistant to high temperatures and the effects of chemicals and is also electrically insulating. Furthermore, glass can filter and refract light. There are various types of glass, with properties that can be put to targeted use. Another advantage of glass is that it is cheap, making it a popular material for research equipment.
Wherever glass is used, the employees of the glassblowing workshop are the first expert point of contact for researchers – for everything from the engineering of complex glass apparatus to repairs of damaged glass items to the efficient manufacture of replacement parts. Another of the glassblowing workshop’s specializations is sealing valuable samples under vacuum in glass containers.
At the glassblowing workshop, the experts do not only manufacture and repair, they also enable researchers to familiarize themselves with the art of glassblowing, for example in regularly held glassblowing courses. Interested parties are always welcome.
Who we are:
The workshop is the center of Technical Glassblowing at the University of Zurich.
Our services:
• Construction and design of glass apparatus in close collaboration with the customer
• Manufacturing of glass apparatus from Duran and quartz glass
• Glass equipment repairs
• Glassblowing courses
• Advice on purchasing of glass ware from international suppliers
• Storage of valuable probes in glass vacuum ampules
Examples of three research projects:
By using a vacuum pump stand, researchers can perform work in a laboratory in a vacuum or inert atmosphere. The equipment for this is tailored specifically to the study set-up.
Thanks to quartz glass’s exceptional heat-resistant properties in combination with water cooling, smelters can be brought up to an extremely high temperature by means of induction heating.
Glass anatomic models are used to prepare for operations and for teaching.
Physics Workshop and Central Materials Warehouse (PWerk)
From Construction to Assembly: The Workshop for Scientists
The Physics Workshop and Central Materials Warehouse is the first port of call for scientists for any mechanical project, no matter if it is the manufacture of complex individual parts or of detectors for large-scale experiments. The Physics Workhop offers an impressive range of services – thanks to the center’ s comprehensive expertise, state-of-the-art machinery, and extensive stock of materials.
The Physics Workshop offers a wide range of customized mechanical manufacturing services including design, construction, and technical implementation –for example with prototype construction, the realization of small batches, and assembly and welding work (including under vacuum).
The experts have a wealth of experience in working with and processing an extremely wide range of materials, ranging from plastics to titanium and from molybdenum to machinable ceramics. Since the workshop also has a very large and extensive stock of materials with many different semi-finished products, even more special starting materials are available at short notice.
Last but not least, budding physicists and federally certified (EFZ) polytechnicians are trained in the Physics Workshop.
Who we are:
The Physics Workshop is UZH’s center with customized solutions for mechanical manufacturing.
Our services:
• Advice, construction, and design in connection with technical implementation
• Five-axis CNC rotary milling
• Laser machining (cutting, engraving, and welding)
• Assembly work
• Welding and soldering
• Very extensive and well-sorted stock of materials
Examples of three research projects:
The LHC particle detectors at CERN in Geneva are largescale international projects with contributions from the Physics Workshop of the University of Zurich. Support pipes with cooling loops were developed and constructed in the Physics Workshop.
For a test as part of the Mu3e experiment at the Paul Scherrer Institute (PSI), special measurement instruments were developed and constructed for the PSI proton accelerator.
Mice like to nibble the fittings in their cages. Special metal drinks holders adapted to the needs of research were developed in the Physics Workshop. Location Irchel Campus Contact werkstatt@physik.uzh.ch
https://werkstatt.physik.uzh.ch
Additive Manufacturing Facility (AMF)
Additive Manufacturing Facility: Where (almost) Everything Can Be Brought Into the 3rd Dimension
Additively manufactured plastic models for medical training? An artificial city for town planning and sociological research? Both are easy to make nowadays. 3D printing is not only suitable for quickly manufacturing prototypes, however. This innovative technology also has other advantages, including its low cost, great freedom of design, and flexible individualization of products.
The AMF experts know what matters in product development and can help transform a researcher’s idea into a functioning product – be it developing new tools and aids for research, realizing models for teaching, or manufacturing replacement parts for machines. The AMF is staffed by a team of specialist engineers.
The advantages of using additive manufacturing for product realization are that the process is very quick and cost-effective. In addition, a wide range of materials and technologies are available and the freedom of design it affords is unrivaled by any other technology.
In other words, there are many possible applications that the AMF service can help researchers, teachers, designers and technical personnel with. Customers can already benefit from the center’s expertise in the planning phase – for example during product development, material selection, or the search for a suitable manufacturing process.
Who we are:
The Additive Manufacturing Facility emerged from the technical workshop of the Department of Biochemistry and consists of a team of specialist engineers.
Our services:
• Advice on technical solutions to manufacture products for experimental setups, tools, illustrations or prototypes of devices
• Engineering, design and 3D-datahandling (CAD, Segmentation etc.)
• Manufacturing of parts and equipment with AM technologies (3D printing)
Examples of three research projects:
The AMF can manufacture artificial mouse tails that veterinarians can use to practice placing infusions. This reduces the exposure of animals to pain and stress.
To enable surgeons to plan and perform operations on complex bone fractures more efficiently, a 3D model of the individual fracture is created using the regular preoperative computed tomography scan.
To be able to use the high-dimensional mesoSPIM microscope operated by the Center for Microscopy and Image Analysis more efficently, the AMF manufactures customized sample embedding and suspension devices for African clawed frog tadpoles. This enables 16 samples to be examined per hour, rather than just one.
Published by: Office for Strategic Research Platforms (UZH)
Concept, text, editing: Remo Sprecher, UZH
Text editing and Translation: Syntax AG, Zürich; Thomas Trüb, UZH; Jacqueline Urfer, UZH; Technology Platforms, UZH
