2014 Annual Report

Accelerating

th e s p e e d of

research, discovery and hope.

ANNUAL REPORT 2014

David and Carol Van Andel

OUR MISSION

Through biomedical research and science education, Van Andel Institute is committed to improving the health and enhancing the lives of current and future generations.

TABLE OF CONTENTS 3 A Letter from David Van Andel

17 Van Andel Institute Graduate School

40 Purple Community Events

5 Accelerating the Speed of Research

19 Accelerating the Speed of Hope

42 Signature Special Event Sponsors

7 Center for Epigenetics

21 Purple Community

43 Leadership Team

9 Center for Neurodegenerative Science

25 Signature Special Events

44 Board and Council Members

11 Center for Cancer and Cell Biology

29 Donor Recognition

13 Accelerating the Speed of Discovery

34 Tributes

15 Science Academy

35 Memorials

VAN ANDEL INSTITUTE

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A LETTER FROM DAVID VAN ANDEL At Van Andel Institute, we’re fast becoming known – and appreciated – for challenging convention in favor of accelerating the speed of research, discovery and hope.

We are proud and grateful for something else as well – a groundswell of growing support that reflects the generous hands and hearts of so many who donate their resources to our Institute.

When Susan Brogger’s mother died suddenly of pancreatic cancer, she established a Purple Community® 5K walk/ run in her mother’s honor to raise awareness and funds for research in one of our labs. To date, she’s raised thousands in her beloved mother’s memory.

When Dr. Willard Van Essen’s wife died unexpectedly, he decided to continue her legacy and highlight her love of science by creating a scholarship partnership with Van Andel Education Institute so that more students could participate in the “Science on Saturdays” program.

Thanks to a significant donation from the Richard and Helen DeVos Foundation, and a collaboration between Van Andel Research Institute and the Spectrum Health Frederik Meijer Heart & Vascular Institute, Rich and Helen DeVos are helping the Institute support innovative research in regenerative cardiovascular therapies.

We are also very grateful for the leadership and guidance of our own Dr. George Vande Woude and the Foundation for Advanced Cancer Research, whose generosity helped establish the Advanced Cancer Studies Fund at Van Andel Institute, representing the largest ever one-time donation to Van Andel Institute Graduate School.

Because of our dedicated, mission-focused donors, the last two decades have been marked by extensive growth, transforming us into a biomedical research and educational institute that has earned admiration and respect around the world.

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100% of your donation

goes directly to the research labs and science education classrooms where we are shaping the future of disease treatment and therapies.

In the last year, we’ve moved forward in ways that have exceeded our expectations.

Leading a talented crop of new research personnel is our Research Director, Dr. Peter Jones, whose strategic plan aims to establish a national hub for epigenetic cancer and neurodegenerative disease research. Jones and his team have recruited worldclass scientists to the Institute and are working with leading research and clinical organizations to move promising epigenetic therapies into clinical trials. To further this mission, the Institute recently partnered with Stand Up To Cancer, a program of the Entertainment Industry Foundation, and committed $7.5 million over three years in support.

On the educational front, the fully accredited Van Andel Institute Graduate School continues to catapult students on to promising career paths. We’ve also expanded the reach of our undergraduate internship program, which draws from a broader geography than ever before. Our Science Academy, for children as young as five, inspires thousands of students each year, and plans are under way to expand our unique science program nationally.

Our corporate partnerships include dynamic entities such as iHeart Media’s B-93.7 FM, where “Country Kicks Cancer” is not only a rallying cry but a focal

point of on-air fundraising drives. Its annual Birthday Bash, to which more than 60,000 country and western music fans flock each summer, has brought our mission to an enthusiastic new audience.

Singer Sheryl Crow has also become our ally and plans to perform a 2015 Nashville concert to benefit our mission.

We must also thank the scores of men, women and even children who sponsor events as part of our Purple Community, raising funds to champion and commemorate those with cancer and other diseases.

Through thoughtful collaborations – and the generosity of so many donors – we will keep making a difference in the lives of others: people who can’t bank on another month, week, or even day. To them, minutes count, and with your help and our efforts, we may positively affect their futures.

Warmly,

RESEARCH P.5

Improving the lives of those living with disease.

You are helping us lead the charge to speed the transition of research from bench to bedside.

DI SCOVERY P.13

Fostering a love of science.

You are helping us light the way with new science education standards and fostering a love of science in students and teachers.

HOPE P.19

Partnering to bring hope.

You are helping us bring hope to the millions affected by cancer and neurodegenerative diseases. ®

David Van Andel, Chairman and CEO

VAN ANDEL INSTITUTE

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Accelerating the speed of research, discovery and hope.

A new therapy for cancer or for a neurodegenerative disease, such as Parkinson’s, has the power to shape the course of human life. Thanks to generous donors like you, Van Andel Research Institute is at the forefront of a new paradigm in biomedical research that aims to streamline the process from basic research to new therapies.

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V A N AA NN DD EELL ERDEUSCEAATRI CO HN II N S T I T UU TT EE

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CENTER FOR EPIGENETICS THE NEW FRONTIER The Center for Epigenetics, formed in 2014 under the direction of Van Andel Research Institute’s Research Director and Chief Scientific Officer Dr. Peter Jones, is at the forefront of a rapidly advancing and promising area of biomedical research called epigenetics.

Jones is one of the world’s leading experts in epigenetics and is determined to build Van Andel Research Institute (VARI) into a globally recognized epigenetics research center. Since his arrival, the Institute has recruited a diverse group of scientists who are exploring the epigenetic modifications involved in a variety of diseases, including cancer, through basic and translational research.

“Patients don’t have 10 years to wait for new treatments, so we need to approach our research with a sense of urgency and work in bold, innovative ways.” – Dr. Peter Jones A priority of the Center for Epigenetics is moving discoveries to a clinical setting where they can be translated into new and innovative therapies. Jones also aims to increase the number of partnerships with numerous collaborators who are experts in conducting clinical trials to ensure that the Institute impacts the future of patient care. The Center for Epigenetics works collaboratively within the Institute as well to streamline existing processes and to explore opportunities for cross-center projects.

In the years to come, Jones is confident that VARI will be the nucleus of global epigenetics research and innovation.

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100%

Dr. Jones and his team need dynamic philanthropic efforts to move their initiatives forward. Because 100% of all donations go directly to the Institute’s labs, individual donors can make a direct impact on the Center’s continued success.

P OW E R F U L PA R T N E R S In 2014, VARI partnered with Stand Up To Cancer (SU2C), a program of the Entertainment Industry Foundation, and committed $7.5 million over three years to support the continued work of the SU2C Epigenetics Dream Team that was established in 2009. Led by Dr. Peter Jones and Dr. Stephen Baylin, the Virginia and D.K. Ludwig Professor for Cancer Research in the Oncology Department and co-head of Cancer Biology at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, the VARI-SU2C Epigenetics Dream Team focuses on developing epigenetic therapies that can be applied to a variety of cancers.

R E G E N E R AT I N G T H E H E A R T Dr. Stefan Jovinge, head of the Laboratory of Cardiovascular Research, is a pioneer in the fields of cardiovascular research and regenerative medicine. Jovinge is also a professor in VARI’s Center for Epigenetics, director of the DeVos Cardiovascular Research Program (a joint effort between VARI and Spectrum Health) and medical director of research at the Spectrum Health Frederik Meijer Heart & Vascular Institute.

At the center of Jovinge’s research is the regenerative potential found in the heart’s cardiac muscle cells and progenitor cells. By unlocking these codes, Jovinge aims to use the heart’s own mechanics to repair itself as well as generating new heart muscle cells from non-heart cells. Jovinge’s work is made possible through Van Andel Institute’s partnership with Spectrum Health and generous funding from the Richard and Helen DeVos Foundation.

Jovinge’s work has far-reaching implications regarding therapies for those living with cardiovascular disease. His research could one day lead to treatment options that repair damaged heart tissue.

The Power of Giving Thank you, Rich and Helen DeVos The collaboration between VARI and the Spectrum Health Frederik Meijer Heart & Vascular Institute was made possible by a significant donation from the Richard and Helen DeVos Foundation.

As a co-founder of Amway, Rich is a legendary entrepreneur, and the DeVoses are among the foremost philanthropists in the United States.

Thank you, Rich and Helen, for your unwavering support of biomedical research that benefits the future of human health.

THE BEST AND BRIGHTEST A host of expert scientists joined the Center for Epigenetics in 2014, diversifying the already impressive roster of the Institute’s principal investigators. The recruitment of top-tier scientists remains part of Dr. Jones’s vision for the Center and VARI as a whole. By enhancing its system of scientific excellence, collaboration, diversity and inclusion, professional respect and an environment of mentorship and learning, the Institute aims to attract and retain the best and brightest scientific minds in the world.

CENTER FOR EPIGENETICS VAN ANDEL RESEARCH INSTITUTE

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CENTER FOR NEURODEGENERATIVE SCIENCE UNLOCKING THE POTENTIAL FOR NEW THERAPIES Moving a new Parkinson’s disease therapy from the lab to the patient costs billions of dollars and takes more than a decade, which represents two of the biggest obstacles facing potential new treatments. Repositioning medications approved to treat other diseases, which have shown promise in slowing or reversing Parkinson’s in preclinical experiments, is one way scientists and Parkinson’s disease advocates are working to cut the time and costs associated with therapy development.

Van Andel Research Institute’s (VARI) Center for Neurodegenerative Science partnered with UK-based research charity The Cure Parkinson’s Trust on the Linked Clinical Trials (LCT) initiative, which aims to reposition drugs approved to treat other diseases and evaluate their potential as Parkinson’s disease therapies in clinical trials.

“We are not interested in the status quo.

We are interested in urgently pursuing novel therapies that don’t just manage symptoms but that actually slow or reverse Parkinson’s and significantly improve people’s lives.” – Dr. Patrik Brundin LCT was founded on the principle that conducting smaller, more costeffective clinical trials gives scientists the opportunity to better identify which therapy is most effective while maximizing the number of clinical trials conducted. The LCT committee is chaired by Dr. Patrik Brundin, VARI’s associate research director and director of the Center for Neurodegenerative Science. The committee has already created an initial list of medications that hold promise for treating Parkinson’s disease.

This unique and powerful partnership leverages innovation, existing knowledge and collaborative networks to provide better treatments and improved quality of life for people with Parkinson’s disease.

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Since 2012, the Center for Neurodegenerative Science has hired more than 40 individuals who are focused on Parkinson’s and related diseases. This is made possible, in part, because of the generosity of donors like you.

GRAND CHALLENGES RALLIES THE PARKINSON’S COMMUNITY More than 350 Parkinson’s disease scientists, clinicians, people with Parkinson’s and caregivers visited Van Andel Institute on September 24 and 25, 2014, for the third annual Grand Challenges in Parkinson’s Disease symposium.

Hosted by VARI’s Center for Neurodegenerative Science, Grand Challenges brought together global leaders in Parkinson’s disease research and advocacy and provided a forum for people with Parkinson’s to interact with experts in the scientific community.

Rallying to the Challenge, a workshop held in conjunction with Grand Challenges, highlighted the many ways people with Parkinson’s can impact the clinical trial process and accelerate access to new treatments. The event was a rare opportunity for people involved in all aspects of Parkinson’s disease to share ideas, strategize and work to improve the clinical trial process.

The Power of Giving Thank You, Ron Rutkowski Ron Rutkowski, a husband, father, businessman and philanthropist, was diagnosed with Parkinson’s disease a decade ago. Dissatisfied with the lack of available Parkinson’s clinical trials and the access to innovative therapies, Rutkowski raised more than $15,000 in three days to support Rallying to the Challenge at Van Andel Institute.

Thank you, Ron, for your dedication to bolstering Parkinson’s disease research. Your support and fervor for discovery inspires others to join the fight.

CONNECTING PARKINSON’S AND DEPRESSION

BUILDING CRITICAL BRAIN MASS

When you think of Parkinson’s disease, you may think of its physical symptoms, but according to Dr. Lena Brundin, the psychiatric symptoms can be the most debilitating.

The Institute continues to expand its research portfolio and increase its impact in the field of Parkinson’s disease research by recruiting talented scientists.

Brundin, head of VARI’s Laboratory of Behavioral Medicine and associate professor at Michigan State University College of Human Medicine, studies how inflammation might play a role in depression in people with Parkinson’s.

In 2014, the Center for Neurodegenerative Science welcomed two accomplished scientists who are focused on specific areas of Parkinson’s disease research—one is an expert in inherited forms of the disease and the other focuses on how a misfolded protein might contribute to disease progression. These additions provide fertile ground for the development of new, innovative therapeutics for Parkinson’s disease.

Brundin believes lifting the stigma of depression among Parkinson’s patients and funding research on the psychiatric effects of anti-inflammatory medications might bring about a shift in how depression in Parkinson’s disease is approached.

C E N T E R F O R N E U R O D E G E N E R AT I V E S C I E N C E VAN ANDEL RESEARCH INSTITUTE

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CENTER FOR CANCER AND CELL BIOLOGY A N A R E A O F G R E AT P R O M I S E Certain types of cancer readily spread to other organs of the body in a process called metastasis, which makes treatment exceedingly difficult. This spread is responsible for the most cancer-related deaths per year in the United States, despite advances in treatment.

The area surrounding a tumor, called the tumor microenvironment, plays a significant role in how a cancer spreads and responds to treatment. By better understanding the microenvironment and the mechanisms that underlie metastasis, Van Andel Research Institute (VARI) scientists aim to improve prognostics and treatment options for cancer patients.

Cancer that originates in the prostate, breast or lung often metastasizes to the bone. Once there, the development of lesions can cause unbearable bone pain.

Current treatments are able to relieve some symptoms but do not increase survival. To find out why these types of cancer are drawn to bone and how they can be stopped, scientists in the Laboratory of Tumor Microenvironment and Metastasis, led by Dr. Xiaohong Li, study the bone microenvironment and the processes that promote prostate cancer metastasis.

“If we can better understand the tumor microenvironment and the mechanisms that cause metastasis, we can improve prognostic and treatment options for cancer.” – Dr. Xiaohong Li The laboratory’s long-term goal is to determine the mechanisms through which the microenvironment contributes to bone metastasis in order to develop innovative, early-prognosis methods and targeted therapeutic strategies for cancer patients.

At VARI, studying the tumor microenvironment and its role in metastasis are vital elements in a diverse research portfolio that is decisively focused on the future of human health.

> 67% More than two-thirds of breast and prostate cancer metastases are found in bone. Individual donors like you allow the Institute to study unique aspects of cancer metastasis, such as the tumor microenvironment, in order to develop improved prognostic methods and therapeutic strategies.

TUBEROUS SCLEROSIS COMPLEX RESEARCH ADVANCES Since launching the Pathway of Hope research initiative in 2013 with the goal of developing new, effective treatments for individuals with tuberous sclerosis complex (TSC), the VARI team has made tremendous progress. TSC causes noncancerous tumors in major organs throughout the body, and patients afflicted with the disease often suffer from epilepsy, learning disabilities and other complications.

Under the direction of Dr. Jeffrey MacKeigan, associate professor and head of the Laboratory of Systems Biology, the TSC research team has screened multiple disease-relevant cell lines searching for novel genes that may be linked to TSC. The team uncovered several intriguing genes that it is investigating as potential therapeutic targets.

Through collaborations with Cincinnati Children’s Hospital Medical Center and Helen DeVos Children’s Hospital, MacKeigan’s group opened a personalized medicine feasibility study, utilizing genomic data to evaluate the potential for personalized treatment plans for those living with TSC. MacKeigan is encouraged by the pace of the project and hopeful that his team’s research into TSC will help uncover information about other tumor-related neurological diseases and cancer.

The Power of Giving Thank You, Susan Brogger When Susan Brogger’s mother was diagnosed with pancreatic cancer and told there was no cure, Susan decided to take action and raise funds to support research into this devastating illness.

Thank you, Susan, for raising more than $28,000 through your annual Mari J. Meyer Pancreatic Cancer Trail Run for Hope.

Your funds support the creation of improved pancreatic cancer diagnostic tools that give others the hope of a brighter future.

VARI SCIENTIST AWARDED FELLOWSHIP Dr. Matthew Steensma, assistant professor and head of VARI’s Laboratory of Musculoskeletal Oncology, was named as a cowinner of the inaugural Francis S. Collins Scholars Program in Neurofibromatosis Clinical and Translational Research by Johns Hopkins University’s Neurofibromatosis Therapeutic Acceleration Program. Steensma, who is also an orthopedic oncology surgeon at Spectrum Health and holds a faculty appointment at Michigan State University College of Human Medicine, will focus his research on new treatments for neurofibromatosis type 1 (NF-1).

NF-1 is a rare syndrome that causes tumors to grow throughout the body and has no unifying therapy or cure. Steensma’s clinical practice includes surgical treatment of tumors in the musculoskeletal system with a focus on NF-1, while his laboratory focuses on developing new treatment strategies.

Thanks to the award, Steensma will collaborate with researchers across the globe with the hope of making great scientific strides in the development of therapies for NF-1.

C E N T E R F O R C A N C E R A N D C E L L B I O LO G Y

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VAN ANDEL RESEARCH INSTITUTE

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Accelerating the speed of research,

discovery and hope.

Great minds in biomedical research begin as curious students. With your support, Van Andel Education Institute is developing science education and teacher training programs that provide today’s students with the tools they need to be the groundbreaking scientists of tomorrow.

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VAN ANDEL EDUCATION INSTITUTE

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The Power of Giving

SCIENCE ACADEMY Q P O E 2 P R O D U C T L I N E E X PA N D E D

INQUIRY-BASED SCIENCE EDUC ATION EXPANDS

The Science Academy continued its development of the innovative QPOE2® product line in 2014 with the introduction of a step book that outlines processes for inquiry-based learning. Focused on kindergarten through second grade students, this new step book incorporates visuals and language designed for beginning readers. The book provides teachers with a framework for engaging young students in the process of thinking and acting like scientists.

A unique partnership between Van Andel Education Institute’s (VAEI) Science Academy and Ottawa Area Intermediate School District (OAISD) is empowering teachers to work together to implement progressive methods in science education for more than 40,000 students.

The creation of a regional teacher network engaged more than 120 teachers from 21 middle schools and high schools to connect, share and collaborate on ways to deliver an innovative method of science instruction in their classrooms, known as QPOE2® (Question, Prediction, Observation, Explanation and Evaluation).

QPOE2 is a model developed by VAEI that gives teachers the tools to implement scientific practice in the classroom. It encourages students to ask questions, take risks and acquire new knowledge. QPOE2 resources are available to educators and students as step books or as an iPad application.

“We are working to transform instructional practice and increase student engagement across science program offerings.” – Dr. Steven Triezenberg VAEI’s instructional method doesn’t change what is being taught but rather how it is taught by helping educators teach students to think and act like scientists. Instead of memorizing facts out of a book, it requires students to discover the answers to scientific questions through their own curiosity, inquiry, research and critique.

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NEW ONLINE TEACHER COMMUNITY

QPOE2

Because of the continuous assistance from a committed group of donors, Van Andel Education Institute is reimagining the power of science education and inspiring young people to pursue careers in science-related fields.

The Ottawa Area Intermediate School District and the Allegan Area Educational School Association joined a new online community in which teachers can collaboratively develop and share lessons and teaching strategies using the VAEI Community of Practice instructional model.

The model’s language and instructional practices allow teachers from different geographical areas the opportunity to communicate, share and work collaboratively.

GRADUATES REFLECT ON LOVE OF LEARNING Established in 2006, the Out-of-School-Time Cohort Program requires fourth and fifth grade students to commit to three years of study for a total of 60 hours of instruction and activity each year. 2014 marked a milestone for the program’s inaugural class as they graduated from high school. Nearly all the graduates are headed to college and acknowledge the significant impact the program had on their education.

Thank You, Dr. Willard Van Essen When Willard Van Essen’s wife Arlene died unexpectedly, he was determined that her love of science would benefit a new generation. Arlene worked for 38 years as a medical technologist and was always fascinated by the wonders that can be viewed under a microscope.

Thank you, Willard, for providing scholarships for students to attend Science on Saturday and giving them the opportunity to explore, investigate and examine their world.

MI L EST ONES

700+

More than 700 students participated in on-site Science Academy programs.

600+

VAEI conducted professional development workshops for more than 600 teachers.

SCIENCE ACADEMY VAN ANDEL EDUCATION INSTITUTE

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VAN ANDEL INSTITUTE GRADUATE SCHOOL

The Power of Giving

LAUNCHING NEW SCIENTISTS’ CAREERS The Van Andel Institute Graduate School (VAIGS) prepares students to become leading scholars in cell, molecular and genetic biology. Through its unique inquiry-based education model, students receive the training necessary to one day lead their own laboratories to groundbreaking discoveries.

The success of VAIGS is most clearly demonstrated with the career paths of its graduates. Ken Valkenburg, a 2014 VAIGS graduate, and Jelani Zarif, who received his Ph.D. from Michigan State University’s Cell and Molecular Biology program, both studied prostate cancer in Van Andel Research Institute laboratories. After successfully defending their dissertations, they accepted postdoctoral fellow positions in the same laboratory at the Johns Hopkins University School of Medicine.

“Van Andel Institute Graduate School provided a unique educational experience that prepared me for a successful scientific career.” – Dr. Ken Valkenburg Scientists around the country acknowledge the value of a VAIGS education, and graduates are highly sought after for postdoctoral fellowships at prestigious institutions.

Additional VAIGS graduates have moved on to positions at University of Wisconsin-Madison, The University of Chicago and University of Colorado-Boulder.

VAIGS students work and learn in a culture that encourages excellence, and the training they receive launches their careers on a trajectory to impact human health.

VAIGS’S INTERNATIONAL REACH VAIGS’s accreditation by the Higher Learning Commission enhances the school’s reputation and allows for the recruitment and admission of international students, promoting the exchange of ideas, research, mutual enrichment and linkages between research and academic institutions in the United States and abroad. Since the accreditation, prospective students from around the globe have expressed interest in the program.

VAIGS CANCER SYMPOSIUM DRAWS WORLD-RENOWNED CANCER EXPERTS The fifth annual Origins of Cancer symposium in July 2014 hosted more than 300 scientists, educators and students and featured presentations from noted international cancer experts. VAIGS students organized the symposium as a graduate-level course in scientific event planning.

The event is especially beneficial to VAIGS students as it brings scientists from around the globe to Van Andel Institute and provides an opportunity to develop valuable professional relationships.

Thank you, Dr. George Vande Woude and the Foundation for Advanced Cancer Research George Vande Woude is a renowned scientist best known for discovering the human MET oncogene, an important cancer target, and for his role as Van Andel Research Institute’s founding research director. He also is known for his generous philanthropy.

The Origins of Cancer symposium will be supported for many years to come thanks to the generosity of the Foundation for Advanced Cancer Research and its leadership, including Dr. Vande Woude, which donated $120,000 to establish the Advanced Cancer Studies Fund at Van Andel Institute. This gift represents the largest ever one-time donation to VAIGS.

MI L EST ONES

Interns Come from Across the Country States represented: MI, IL, FL, MD, VA, NV, TN, MN, MA, NJ, WA G R A D U AT E S C H O O L

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VAN ANDEL EDUCATION INSTITUTE

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Accelerating the speed of research, discovery and hope.

Great accomplishments are the result of passionate people connected by a common mission.

Van Andel Institute is grateful to be supported by an engaged community of individuals and businesses who believe in impacting human health. Thank you for being a part of our mission.

速

VAN ANDEL INSTITUTE

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PURPLE COMMUNITY ®

PURPL E COMMUNI T Y I MPACT

W H AT ’ S YO U R P U R P L E ?

PURPLE COMMUNITY CROSSES THE U.K.

When businesses partner with Purple Community, they’re often motivated by a personal connection to cancer and neurodegenerative diseases as well as a desire to change the course of human health. These businesses consider their unique motivation their “purple,” and in 2014, they joined thousands of Purple Community members by answering the question “What’s your purple?” Together with their employees, they set impressive goals to contribute to Van Andel Institute’s (VAI) research and science education initiatives.

Laura Shelburne trekked 84 miles along the ruins of a Roman wall that runs across northern England to emphasize the devastating physical effects of Parkinson’s disease. The hike was made in memory of her father, Dr. Charles Clinton Lewis, who had Parkinson’s.

Through her efforts, Laura raised more than $4,000 for the Institute’s Center for Neurodegenerative Science. Thanks to steady support from passionate individuals like Laura, great strides are being made to discover improved diagnostics and treatments for Parkinson’s disease.

Regal Investment Advisors (Regal) turned an annual event for their advisors into a fundraiser for VAI. Regal hosted more than 225 employees, clients and VAI supporters at a rooftop venue to enjoy a Chicago Cubs baseball game. The event raised $24,000 for biomedical research.

“We believe that everyone should do their part to fight for a cause. It’s our goal that this partnership will help those dealing with a genetic disorder or disease.”

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42% first-time fundraisers

When you partner with the nation’s leading country music radio station and largest FM signal, there are no limits to what you can accomplish!

Purple Community had the privilege of fostering a new partnership with radio station B-93.7 FM in 2014 to support the Institute’s work.

$1 Million In 2014, Purple Community surpassed the $1 million raised milestone.

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fundraisers

B-93’S COUNTRY KICKS CANCER AMPLIFIES PURPLE COMMUNITY

– John Kailunas, II, Regal Investment Advisors Founder and CEO

Thanks to these partners and their unique approaches to fundraising, Purple Community is more successful than ever before. Together, we can make a lasting contribution to innovative biomedical research and science education.

170+

The partnership began at the B-93 Birthday Bash in June and culminated in a 12-hour radio marathon in September, which raised more than $33,000 for cancer research at the Institute. The Country Kicks Cancer fundraiser honored the stories of listeners with a personal connection to cancer, providing hope to thousands of people.

In 2014, Purple Community launched a new online store at purplecommunity.org/store.

Proceeds from all sales benefit Van Andel Institute.

PURPLE COMMUNITY VAN ANDEL INSTITUTE

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PURPLE COMMUNITY ® PARTNERS IN HOPE Community engagement is a powerful cornerstone of Van Andel Institute (VAI). Biomedical research and science education have the potential to bring about discoveries that can impact the course of human health. Because of the impactful nature of the Institute’s mission, business and community organizations of all sizes have continued to lend their generous support.

“We were inspired by the work being done at VAI, and we’ve spent the last year raising funds to support its research and education programs. Nearly everyone is affected by cancer or disease in some way, and we want to do our part. ” – Carol Smith, owner of Great Lakes Scrip Center Employees at Great Lakes Scrip Center (GLSC) completed a yearlong fundraising competition in 2014 to benefit VAI. Employees had the opportunity to meet with research staff, take a tour of the Institute and learn about the Institute’s history. Following this meeting, GLSC employees formed fundraising teams in order to raise the most funds possible. Over the course of a year, the teams raised funds by holding company-wide events and promotions.

Their efforts totaled more than $51,000 at the end of the year. The experience united the organization in the service of a common cause and provided important funding to support VAI’s biomedical research and science education.

“Hops for Hope is a clever way for breweries and patrons to support Purple Community because it raises awareness and funds for Van Andel Institute in a fun atmosphere where you wouldn’t normally expect it. We’re proud to participate in this program.” - Tapistry Brewing

HOPS FOR HOPE TAPS MICHIGAN BREWERIES The rise of craft beer breweries provided promising opportunities to Van Andel Institute’s Purple Community in 2014 with the launch of Hops for Hope – a collaborative effort among breweries to raise funds for cancer research through the sale of beer.

Hops for Hope included seven breweries in its inaugural year, with locations ranging across a wide landscape, including Tapistry Brewery and Saugatuck Brewing Company, plus 11 additional restaurants and pubs.

Proceeds were generated through the sale of beer growlers and select pints of beer, totaling more than $10,000 over a two-month period from September through October.

Bill and Jenn White, owners of White Flame Brewing Company, have a close tie to the cause. The couple helped establish Hops for Hope at the Institute – where Jenn has worked in the Laboratory for Cancer and Developmental Cell Biology for 12 years – after her father lost his fight with lung cancer.

“My father was the healthiest person I knew,” said White. “For him to be diagnosed with metastatic lung cancer was shocking and incomprehensible, but it taught me a valuable lesson: no one is immune from its devastation.”

Thanks to the Whites’ vision and close connection with Michigan brewers, Hops for Hope will continue to raise important funds for the Institute’s research initiatives in 2015.

PURPLE COMMUNITY 23

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VAN ANDEL INSTITUTE

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SIGNATURE SPECIAL EVENTS Van Andel Institute’s signature special events are a time to celebrate, raise funds, support research and science education, and honor individuals who have promoted the Institute’s mission.

5 cities

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SHERYL CROW CONNECTS WITH VAN ANDEL INSTITUTE NE TO I M AD ADMIT ONE

events hosted by Van Andel Institute in 2014.

175+

sponsors participated in special events to support biomedical research and science education.

Sheryl Crow is a singer and songwriter who bridges the gap between the feel-good sensibilities of pop music and the rich history of country music. She is also an artist who uses her talents in the service of important causes. Thanks to a partnership with B-93.7 FM, the nation’s leading country station and largest FM signal, Crow was introduced to Van Andel Institute in summer 2014. Crow performed an intimate show for donors, Institute staff and representatives from country music radio. After hearing about the Institute’s innovative biomedical research and science education programs, she agreed to perform a Nashville concert in 2015 to benefit the Institute’s mission.

The event, entitled “Hope & Denim,” will help amplify awareness of the Institute’s mission to a new market and raise important funds, 100% of which go to benefit biomedical research and science education initiatives at the Institute.

hosted Van Andel Institute National Initiative events: Hilton Head, Chicago, Washington, D.C., Detroit and New York City.

SPECIAL EVENTS 25

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SIGNATURE SPECIAL EVENTS RECOGNIZING SIGNIFICANT CONTRIBUTIONS The annual Carol Van Andel Angel of Excellence Award honors those who have made a significant contribution to the Institute through volunteer service, philanthropy, special event support, innovation or scientific support. The annual event has honored business leaders, entertainment personalities and grassroots fundraisers.

The award may be based on a single project or contributions through multiple projects over time. The recipient may be from any walk of life or discipline and may not be an employee of the Institute. The personal attributes of the award recipients should be of the highest professional integrity, and their contributions should be consistent with the mission of the Institute.

In 2014, Van Andel honored a group of high school students from Forest Hills Central High School for raising more than $100,000 to benefit the Institute’s biomedical research programs. The four young women worked with the Institute’s Purple Community fundraising program to hold ‘purple’ events at their school and rally student support.

“These women embody everything about the Angel of Excellence Award.

They are amazing leaders in their community, and their commitment to giving back and helping improve human health is truly an inspiration to us all.” – Carol Van Andel Van Andel also honored Lori “Maranda” Cook, host of Maranda Where You Live on WOTV 4. Maranda is a strident supporter of VAI’s mission and advocate for Purple Community. Maranda utilizes her influence as a broadcaster to help support VAI and has empowered thousands of individuals to volunteer and contribute to community-based causes.

Events such as the Carol Van Andel Angel of Excellence Award showcase the powerful philanthropic and mission-based support the Institute receives from an ever-increasing base of community activists.

SPECIAL EVENTS 27

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VAN ANDEL INSTITUTE

28

Sources of Funding for Research and Education

10%

15%

Private Philanthropy

Grant & Contract Revenue (Indirect)

14% Grant & Contract Revenue (Direct)

76% Endowment Income

229 9

Sources of Funding for Operating and Overhead Expenses

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DONORS

Because of your generosity, we are accelerating our research and finding innovative ways to translate our laboratory results into patient treatment options faster and more efficiently. Every day in laboratories and classrooms, we see your support making an incredible difference.

Thank you for partnering with us.

Endowment Income & Other Revenues

Bluewater Technologies

Amway Grand Plaza Hotel

Bodies of Art

Robert and Carol DeVilbiss Aaron and Afton DeVos

Mathew and Jennifer Fahrenkrug

Grandville Public Schools

Ralph and Melissa Iannelli

Laura Mercier

Gary and Pam Granger

Ice Sculptures, Ltd.

Law Weathers

Charles Anderson

Charles and Christine Boelkins

The Dick and Betsy DeVos Family Foundation

Bea Idema

John Leese

John and Sharon Bouma

The Stephen M. Coffman Charitable Trust

The Granger Group

Aon

Tim and Laura Feagan

Great Lakes Scrip Center, LLC

Ilitch Charities

Leigh’s

Aquinas College

BPV Capital Management

Colliers International

Ferris Coffee & Nut Co.

Greenville Public Schools

Illinois Tool Works Foundation

Leo’s

Blanche E. Ash Trust

Patrick and Kristine Brady

Love and Valeda Collins

The Douglas and Maria DeVos Foundation

Fifth Third Bank

José and Sue Infante

Lighthouse Insurance Group, Inc.

Brickey Land Company LLC

Color Run

Douglas and Maria DeVos

Martin and Peggy Greydanus

Tess Bagley

First National Bank of Michigan

Ingredion Inc.

The Local Epicurean

Don and Karen Baker

James and Donna Brooks

Scott Fiser

Timothy Haak

Win and Kyle Irwin

Ray Loeschner

Steve and Kathryn Bandstra

Patrik and Lena Brundin

Compass Group USA - Eurest Dining Services

The Richard and Helen DeVos Foundation

The H.T. Hackney Co.

Peter C. and Emajean Cook Foundation

Eileen DeVries

Flowerland

Jana Hall

Michael and Sue Jandernoa

Tim and Kimberly Long

John and Melynda Folkert

Dan Hammersmith

Sidney and Sharin Jansma

Lord, Abbett, & Co. LLC

Cook Holdings

Jack and Mary DeWitt

Margaret Fondren

Arthur and Betsy Hasse

Sidney and Cate Jansma

LPiTsolutions

Covenant Christian High School

Ralph Hauenstein

Charles and Carole Johnson

Gary and Vicky Ludema

William and Anita Crawford

Marvin and Jerene DeWitt Foundation

Forest Hills Public Schools

Paul and Sheryl Haverkate

Peter and Veronica Jones

Jack Lukens

Bill and Marilyn Crawford

Dickinson Wright PLLC

Foundation for Advanced Cancer Studies

Daniel M Helmholdt

Richard Jones

Lundbeck Research USA, Inc

Crowe Horwath LLP

Jeffrey and Mary Dixon

Mark and Valerie Henderson

Richard Jove

Michelle Lunn Hope Foundation

Deborah Crum

DK Security

Herman Miller

Joseph and Elizabeth Junewick

Don and Peg Luy

Mimi Cummings

Brian Dudley

Bob and Barbara Herr

John and Deb Kailunas

Dave and Karen Custer

The John Dykema and Michele Maly-Dykema Family Foundation

Paul and Rose Heule

Brad and Gayl Kessel

Dr. Jeff and Shannon MacKeigan

John and Gwen Hibbard

KiMe Fund

Richard and Terri MacKeigan

Dan and Diane Hickey

Craig and Debra Kinney

Mager Scientific

Philip and Sharon Hoekstra

Donald Klopcic

Donald and Kathleen Maine

Dirk Hoffius

Steven Klotz

Andy Holtgreive

Kohler Expos, Inc

McDonnell Investment Management, LLC

Mark Holtvluwer and Wendy Parr Holtvluwer

Nathan and Nancy Kooienga

Homewatch Caregivers of West Michigan

Blake and Mary Krueger

The Bank of Holland

Kerry and Laurie Buettner

Bar Divani

Buist Electric

Kevin and Michelle Bassett

James and Martha Bultman Bill and Jackie Bylenga

Battle Creek Community Foundation

Greg and Carlin Bylsma

VAN AN D EL I N S T I T UTE FO U N D ER S

Nancy Batts

Byron Center Public Schools

Batts Foundation

Calamos Advisors

Jay and Betty Van Andel

Bay Valley Foods

Caledonia Lacrosse Association

John H. and Nancy L. Batts

BBI Holdings LLC

Gerald and Suzanne Callahan

Richard and Helen DeVos

Bengtson Center for Aesthetics and Plastic Surgery

Ralph and Grace Hauenstein

John and Micki Benz

Sidney and Joanne Jansma

Berends Hendricks Stuit Insurance Agency Inc.

Fred and Lena Meijer

The Chop House CitySen Lounge

Fastsigns

Regena Bassett

Peter C. and Pat Cook

85%

Amway

Berger Chevrolet Inc. $1,000+ DONORS

Scott and Natalie Bernecker

Adamas Pharmaceuticals, Inc

Gregory and Rajene Betz

Advisory Research, Inc.

Kenneth and Judy Betz

Allegiance Marketing Group

Betz Industries

Martin and Sue Allen

David and Jill Bielema

William Alt

Biogen Idec

Amore Trattoria

Don and Bridget Bittner

Carol L Bylsma

Calvin College Lis B. Campbell Mark and Martha Campbell Scott and Heidi Campbell John and Marie Canepa Mike and Kim Carnevale Carnevale Interactive Cascade Fellowship CRC Cascade Rental Center Kelley Cawthorne Certified Tile and Stone Installers Arnie Chance

Custer Workplace Interiors Custom Printers Cygnus27 Czech Holdings LLC Davenport University Jerry and Karen DeBlaay Douglas and Margaret DeCamp Thomas and Jacquelyn DeJonge Douglas and Sandra Dekock Deloitte Detroit Red Wings Ed DeVilbiss

Dewaal Properties

Thomas and Lois Dykstra Eenhoorn, LLC Ellis Parking Company Kathleen Ellsworth Steven and Karen Ender Barbara Erhards Erhardt Construction Ernst & Young LLP Eurest - Van Andel Institute Cafe Jim and Gail Fahner

Bo and Jennifer Fowler Fox Sports North Peter and Lisa Foy David and Judy Frey Dan and Lou Ann Gaydou Gazelle Sports Charles and Julie Greenen General Electric Healthcare Robert and Paula Geyer Gillis Family Chiropractic Gene and Tubie Gilmore The Gilmore Collection John and Nancy Gordon Grand Rapids Catholic Secondary Schools

Hope College

Grand Rapids Christian Schools

John and Janyce Huff

Grand Rapids Griffins

J.C. and Tammy Huizenga

Grand Valley State University

Humana

Andrew and Maribeth Howard

Al and Robin Koop L & V Development Allen Laan Lake Michigan Credit Union Lakeside Camp Park, LLC Joseph and Amanda Lanser Kenneth Larm

Medawar Fine Jewelers Medtronic, Inc. Hank and Liesel Meijer Meijer The Meijer Foundation Merrill Lynch - The Veldheer, Long, Mackay & Bernecker Group Metro Health Michigan State University

VAN ANDEL INSTITUTE

30

DONORS ( CONT INUED) Michigan State University College of Human Medicine

OSI Restaurant Partners

Lynn Russell

Thomas and Mary Stuit

Willard Van Essen

Otsego Public Schools

Philip Rydel

Donna Van Haren

Mika, Meyers, Beckett & Jones, PLC

Richard Pappas

San Chez, A Tapas Bistro

Summit Financial Group of Indiana

Parkinson’s Disease Foundation

Sanders Foundation

Duke and Sue Suwyn

Randy and JoAnn Van Hoven

PB Franchising

Martin D. Sass

Synthonics

Howard and Van Mersgergen

Pigeon Hill Brewing Company

Saugatuck Brewing Company

Taconic Charitable Foundation

Dave and Beth Van Portfliet

Pioneer Construction

Jacquolyn Sawyer

Michele Taipalus

John and Beth Van Tongeren

Michael Schaap

Logan Tassoni

Jamie Mills

Lewis Pitsch and Teresa Hendricks-Pitsch

Gordon and Margaret Van Wylen

Mark Scherphorn

Team Hannah

Mills Benefit Group, A Lighthouse Company

George and Dot Vande Woude

Plastic Surgery Associates, PC

Daniel Schlenk

Tempting Tables

Brian and Lori Vander Baan

The Mitten Brewing Company

Pokagon Band of Potawatomi Indians

Scott Christopher Homes

Patricia Ter Haar

Stuart and Nelleke Vander Heide

Modern Day Floral

Teva Pharmaceuticals

Pre-Soma

Scott Group Custom Carpets

Michael and Gayle VanGessel

Louis and Nancy Moran

John Thiel

Pretty Persuasions

Peter and Joan Secchia

Jean VanSweden

The MSJ Foundation

Thoroughbred Fulfillment

Preusser Jewelers

Secchia Family Foundation

Jim and Mary Veldheer

John Mulder

Thousand Oaks Golf Club

Edgar & Elsa Prince Foundation

Blair and Michelle Sharpe

Mark and Elizabeth Murray

Townsquare Media

Reeths Puffer Schools

George and Missy Sharpe

Veolia Energy Grand Rapids LLC

Tim and Denise Myers

Traverse City Beach Bums

Lonnie Vis

Regal Financial Group LLC

George and Linda Sharpe

N VINT

Tre Cugini

Ray and Mary Vonck

Renovo Neural

The Sharpe Collection

Neiman Marcus

Budge and Marilyn Sherwood

Steve and Laura Triezenberg

VWR Charitable Foundation

David and Carol Rice

Network For Good

Six.One.Six

Trinity Health

Walmart

Brad and Julie Rick

Neurofibromatosis Support of West Michigan

Warner Norcross & Judd LLP

David Ristou

Brent and Diane Slay

Tuff-Cover Inc.

Jack and Carol Smith

Twisted Rooster

Special Events Party Rental, Inc

U.S. Bank National Association

Wayne State University Physician Group

Spectrum Health

UCB, Inc.

Wells Fargo Advisors

Fred and Julie Spica

United Way, Heart of West Michigan

Wells Fargo Foundation

US WorldMeds, LLC

Richard and Diane Wendt

Steve Van Andel

West Michigan Eyecare Assoc.

The Steve Van Andel Foundation

West Michigan Hockey Youth Foundation

Philip and Patricia Van Baren

West Michigan Hockey, Inc.

Howard “Buzz” Miller Howard Miller Company Jack H. Miller Miller Johnson

Jim and Christine Nicolette Jerry and Marcia Niewiek

31

Rockford Construction Company, Inc.

Jeff and Deborah Nol

Rockford High School Boys LaCrosse

Norris, Perné and French LLP

Root Lowell Manufacturing Co.

Northern Jet Management Northern Star Broadcasting

Rottman Family Charitable Foundation

Fred Novy

John and Therese Rowerdink

John and Gail Nowak

Rowerdink, Inc.

Juan and Mary Olivarez

Fred and Kathy Rozema

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Robert and Beth Spica John and Judy Spoelhof Foundation Stadium Management Co Robert and Susan Stafford Claire Stallings Steelcase Inc.

Gordon and Mary Van Harn

West Michigan Sports Commission Western Collegiate Hockey Association Peter and B.J. Whigham Whitecaps Community Foundation David and Anne-Lise Whitescarver Scott and Rebecca Wierda Steven and Juliana Wilkening Jim and Sue Williams Greg and Meg Willit Wolverine Worldwide, Inc. Women’s Lifestyle Magazine WOOD-TV John and Kathleen Workman Liam Sullivan and Linda Zarzecki

Wells Fargo N.A.

Daniel and Ann Marie Van Eerden

VAN ANDEL INSTITUTE

32

TR IB UTE S

Many of our supporters choose to celebrate an individual or special occasion with a gift to Van Andel Institute.

We appreciate your contributions and celebrate with you.

Roseann Aleksynas Robert Varty Rod Andres Mary Andres Barbara Appledorn Shirley Brookhouse Patricia Diekema Jack and Judy Payne Sheryl Smith Al and Jo Arnoys Eric Arnoys Gordon Arnoys Marlan Arnoys Robert and Dawn Arnoys Roland and Jeanne Barchinger Richard and Marjorie Haines Grace Nyenhuis David and Carolyn Setsma Betty Tymes Deborah Balk Elijah Gaipa and Family Larry and Erin Barryhill Brad and Stacy Berkshire Jeremy Croff Kathryn DeWitt John and Monica Ligerakis Kevin and Christina Miller

33

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T H E S E G I F T S H O N O R A FA M I LY M E M B E R , F R I E N D O R C O L L E A G U E W I T H A C O N T R I B U T I O N T O T H E I N S T I T U T E I N 2 0 1 4 .

Jerry Nienhuis Becky Profit Sarah Spannagel Mary Tackbary Katie Zeiter

Aaron Garrett Dianne Garrett

Julie Malefyt Richard and Joan Broersma

Hope Robinson Dawn Anderson

J.R. Vos Matthew and Shari Berger

Diane Gohlke Keith Gohlke

Alvin Masselink Herbert and Kathleen Dershem David and Jill Goetz

Jerry Seeman Gary Arthur

Brian Whalen Robert A. Congdon

Paul Berning Audra Berning

George Grimes James Horman and Laurel Grimes Horman

Jack and Carol Smith Steve Hutchison

John Zant Rosie Zant

Harold Steele Marcia Steele

Marc Zuppke Beverly Niedelson

Robert Stoming Homewatch Caregivers of West Michigan

Jeff Zylstra David and Mary Bristol

Rachel Bolger Marcia Bird Matt Bolger and Maureen Watson - Bolger Marguerite Bowen Susan Formsma Barbara S. Bradley Douglas and Michele Bradley James and Sheral Bradley Nancy Buchanan Erin Buchanan Mary Campbell Joyce Russell Sharolyn Conklin Lorraine Weatherwax Shirley Curtis Spencer Curtis Delva Evans Lauren Walker Kimberly Flynn James Flynn Linda Ford Janet Berrios Janet Foy Peter and Lisa Foy

Michigan Realtors Past P. Group Jodie Cady Jana Hall Dawn Ching Elizabeth Harmon Daniel Jormuth and Sarah ParkerHormuth Mary Kay Jaremav Arline Dzwonkowski Judy Kearns Donald and Gina Bazany James Kearns David and Sallie Brinks Erin Lamb Peter and Lisa Foy John E. Leese John and Mary Leese Milt & Ed Lennox-Ladner William Andersen Bruce Dybas Gary Platte N. Thomas Rogness Donald W. Maine Laura Pickard

Alaine Mast Charles and Sue Freriks David and Jill Goetz Kenneth and Thelma Timmer Joyce Mertens Danny Mertens Gayle Miranti Susan Miranti Ian Murillo Ian Murillo Sarah Murphy Frank and Sally Chlystek Paul Osenieks David and Sallie Brinks Larry Pattison Carole Yost Phyllis Pelton Kara Heck Frank Popiel Mary Miller Garrett Reinartz John and Amy Reinartz Katelyn Mai Reynolds Randall and Anna Reynolds Jeffery Roberts Leslie Farcy

Edward Stuursma Joan Stuursma Clarence Suelter Carl and Jenifer Nelson Lilliana Tanis Kenneth Larm James Tassoni Accuracy Temporary Services Grandma V Elizabeth Stelpstra David and Carol Van Andel Jim and Gail Fahner Carol Van Andel Dave and Deborah Wurfel George and Dot Vande Woude Kevin and Michelle Bassett George Vande Woude David and Susan Birdsall Chad Vollmer Terry Vollmer

VAN ANDEL INSTITUTE

34

MEMO RIA L S

For our friends who have lost a loved one, we mourn with you.

We appreciate your trust in us to fight disease in memory of your family and friends – with the hope for a healthier tomorrow.

Allison Aardema Steven and Julie Aardema Deb Accorsi Homewatch Caregivers of West Michigan Rose Akin Timothy Haak William Alexander Harvey and Susan Powers Robert and Vivian Anderson David and Lynne Robinson Cindy Antonides Ricky and Debbra Yeager Frank L. Archer Mary Kay Schoon Alyssa Arends Gerald and Mary Byrne Stephen and Peggy Camiller The Folkertsma Family G-Summit of West Michigan Dean and Beth Havens Patrick and Patricia Hipp Dianna Hodson KJ Conaty Company Laura Koster

35

Sandra Marston John and Susan Nelson Norman and Loretta Orsette Kenneth Scheibach South Elementary Teachers Kurt and Rita Sultemeier Theodore and Sarah Vereecken Kenneth Arends Thomas and Barbara Arends Jan Baar Judy Chatterson Robert and Susan Decker Edward Deuling James and Janice Deuling Gigi Garcia Kirby King Michael and Krausman Tobi and Jeanette Lake Randy and Jen Searles Debra and Stalsonburg Stan and Mary Jo Szymanski Charlene Vig Mary Badanek Katherine Sanders Patricia Baker Lori Steffes Keith Bassett Regena Bassett John H. Batts Bissell Inc. Florence Bouwman John and Janet Boyles Jim and Donna Brooks Paul Brown Barbara Bunbury Henry Fox Thomas and Mickie Fox Roger and Anne Gamache Joan Hoffs Lester and Vivian Hoogland Win and Kyle Irwin

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Thomas and Margy Jones Victoria Kimball Arend and Nancy Lubbers Troy and Claudia Scharlow V. Parker Tuthill Robert and Virginia Vallee L.J. Verplank Michael and Lisa Warren Mary White

James and Judith Czanko Terry and Robin Darling Peter and Ann Dejong Larry and Sona Gray Callie Higgins Jerry and Carol McGillicuddy John and Gloria Sorensen James and Lois VanVeghel Norma Wheeler

Daniel Beckmann George Beckmann Maggie Beckmann Linda Feighner Patrick and Dana Franzoi Network 180 Herbert Tanner and Stacey O’Toole

Wallace Boelkins Arthur Anderson Patrick and Kristine Brady Marion and Linda DeJong Linda Ernst Kathryn Francisco Debra Gorby Pat and Julie and Greene William and Jody Hall Kimberly Hilton Gordon and Marge Konyndyk Nathan Pegman Jeffrey Spidell John and Pat Steffen Robert Surman Jennifer Sybesma-Boyd Thomas and Carole Van Dam Robert and Heidi Veenema Michael Veurink

Jeanie Belliel Joseph and Anne Marie Bialczak Dinny Berger Matthew and Shari Berger Nicole Beuschel Sue Baar Kathy Headley Keith and Sally Hulsman Maynard and Yvonne Van Noord Dave and Cathy Zokoe Roland Beute John Begerow Nicholas and Susan Beute Roger and Nancy Clouse Dara Levine-Hillis Ben Morgenthau Thomas and Meredith Pak Gregory Park Ernest Bevins David Bevins Roberta Black James and Cheryl Blanchard

Gregory Bogert Jim and Joyce Thomasma Glenn Bonkosky Gerald and Tracy Kneeshaw Marvin Boshoven Homewatch Caregivers of West Michigan James P. Bouwman William and Bernice Azkoul Nancy L. Batts Laurence and Genevieve Bratschie Robert Browne

Dirk and Lisa Buth Irene Callaway Stanley Cheff James and Mary Louise Conway Arlene Costigan Robert and Barbara Crossman Thomas Davis Lois Eberhard-Beckering Patricia Edison Mark and Karen Falahee Vicente Gracias Ann Hagerman Priscilla Hallas Homewatch Caregivers of West Michigan Marilyn Hunting Thomas and Margy Jones Janice Kirchgessner Ray Loeschner Jack Lukens Calvin Owen Phyllis Palmer The Mary Ponsetto Trust Alice Porter Robert and Janette Reid Dale and Jane Rhoades Kimberly Ridings Patricia Stichnoth Dell and Connie Sweeris John and Dorothy Terhune Daniel and Betsey Tinkham Beatrice Vander Mey Marilyn Vanderveen Edith Vasu Amy Wilcox Charles and Sally Wilson Dick and Barbara Young

Jeffrey S. Buchanan Alex Dinu

Karl Daniels Joel and Molly Vanderiet

Anne K. Driscoll Donald and Kathy Canham

Suzanne J. Buche Ben and Nora Poquette

Barbara David Gail and Susan Foxworthy Douglas and Joellen Pinckney Tom and Rosanne Stream Jill VanOeffelen Doug and Stella Weston Walter Weston

John “Jack” Duggan Michael and Patricia Breen Steve and Jeanette Fleming John and Cathie Fullenkamp Nicholas and Jody Kentopp Edwin and Patricia Rejda Karen Schultz Robert Sheldon Mary Lou Sorensen

Shane R. Brickey David and Beth Anne Russell

Emery Crisman Homewatch Caregivers of West Michigan

Kevin Brower David and Angela Mitchell Richard D. Bruchmann Arlo and Claudia Van Diest

Jeanne Buiter Robert and Karen Ensink Bob Burgers Jason and Kimberly Jerke Peter G. Bylsma Carol L. Bylsma Frank Campbell Lis B. Campbell Paul and Lynn Getzin Kathern Carlisle Michael Carlisle Mary Carnevale Mike and Kim Carnevale Molly A. Cavera Kelly and Elizabeth Graham Sharon Hamacher Cathy Oosse Dennis and Emily Teed Michael J. Cleland Lisa Myers Hildegarde Crawford Homewatch Caregivers of West Michigan

Barb Daniel Michael Lamb

Jay A. DeBoe Michael DeBoe Clare DeLoy Elita J. Wood Jordan Dionne Judy Bloodworth Kenneth Ecans Jon Farmer Jennifer Garone Douglas Montgomery Darlene Norden Deb Nykamp Tania Rentz Kevin Yoder Liam A. DiRoma Shelley Fleischman Cherry Griffith Andrew Howley Bert Docter Al and Joyce Docter Carson Donley Lizann Donley Jim Dorneer Timothy and Beverly Held Kathleen Drennan Patrick and Kristine Brady

Robert H. Dykstra Tom and Lisa Smith Bud and Ruth Elve Mark and Anne Elve Albert Ensink Robert and Karen Ensink J. F. Erhards Barbara Erhards Arlene Faber Cynthia DeBoer Florence DeBoer Grand Rapids Firefighters Retirees Associatioin Daniel and Cathy Wisniewski Adeline A. Falerios Charles and Sue Sloop John Fishback Maryanna Johnson Joyce Prichett Bill Fondren Margaret Fondren Terrie Frank Arlene Leben

Vearl Garland Dave and Carrie Boer Thomas and Becky Mikowski Eileen Gifford Steven Klotz Norma J. Girod Marjorie Bishop Robert and Carol Bolt John and Anne Borduin James Brady Brookdale Senior Living Inc. Mary Buist Love and Valeda Collins Ron and Lori Cook Richard and Kay DeVoogd The Dick and Betsy DeVos Family Foundation The Douglas and Maria DeVos Foundation Mark and Anne Elve Robert and Kay Faasse Jim and Gail Fahner Steve French David and Judy Frey George and Dorothy Gaastra Grand Rapids Christian Schools Ann and Shane Hansen Michael Hoffman Julie Hull Robert and Paulette Israels Nicholas Kroeze Jason and Kelly Lovell Richard and Terri MacKeigan Shannon Matthews Michigan Colleges Alliance R. George Mickel Greg Willit and Meg Miller Willit Opera Grand Rapids Norman and Janet Pylman Will and Lauretta Rosado Fred and Barbara Rosendall John and Beverly Scranton Robert Boss and Virginia Seyferth

Spectrum Health The Right Place, Inc. Dave and Beth Van Portfliet Bruce and Mary Visser Wedgewood Christian Services David and Anne-Lise Whitescarver Dave and Deborah Wurfel Paul J. Gislason Steven and Karen Ender Harry and Thelma Gohlke Keith Gohlke Ray Goodsell G & S Mini Storage Chris Gordon Jack and Barbara Ballema Larry and Judy Crittenden Elizabeth McGinnis-Haley John Palladino Howard and Connie Peterson Melissa Peters Raymond and Marilyn Prill Jack and Joan Puleo Scott Richman Scott Richman Kenneth Wagar Carl Greer Carla Miller Michael Gustafson Brian and Lori Carroll Darlene Krull Lever Interactive O’Sullivan Family Linda H Brianne Sieting Carol A. Haarman Stephen Haarman

Bernice Hansen Timothy and Beverly Held

Steven M. Hertel Antoinette Hertel

Bruce L. Hansen Patricia Ter Haar

Jane Hibbard Idema Frederick and Carey Idema Margaret Idema

Janet Haverdink Thomas and Frances Apsey Stella Bergman Don and Merle Chrysler Glenora Dancer Darla Decator Matthew and Linda Elenbaas Gregory and Patricia Hanson Kenneth and Cheryl Haverdink Wayne and Fran Haverdink Donald and Virginia Kalawart Steve and Joanne Kooi Lake Michigan Dental Ida McDougal Dorothy Milanowski Erma Roberts Ralph and Lynnora Robrahn Tom Smith Daniel and Nancy Wiersma Rosemarie Haviland Denise Fedko James Hayford Dennis and Joanne Kozarek Dave Heeke Paul and Charlene Fitzpatrick John Heeren James and Janice Heeren George and Jackie Hein Jenna Wey Robert L. Heit Homewatch Caregivers of West Michigan

Jim Hickey Catherine Amodeo James Hoekstra William and Yvonne Van Ee Thomas S. Holmes Ron and Mary Jane Mass Gale and Marilyn McNitt Howard and Evelyn Shears Todd Zynola Ken Holtvluwer June Holtvluwer Robert Horgan Craig and Debra Marshall James Hosford Bruce Tuttleman Carole Hubbard Charles and Carole Johnson Joanna Huebner Roger and Susan and Bratt Elaine Hylland Linda Olson Wesley Jaeger Robert Jackson Lori Jasperse Redmer Carol Lautenbach Richard S. Jenson Lyle and Jackie Irish

VAN ANDEL INSTITUTE

36

MEMORIALS (CONT INUED)

Stanley Kaye Brian and Erica Lesiewicz Mark R. Kemperman Douglas and Charlotte Baines Sam DeLuca Brendan and Elizabeth Geary Carl and Kelly Jandernoa David and Suzette Lynn Meyer Gerald and Sally Moore Timothy and Ruth Moore Edward and Patricia Moor Julie Otterbein William and Linda Prescott Molli Templin Jean Khouri MaryAnn Maloley Woodrow J. Kilmartin William and Alice Cleary Lyle and Jackie Irish Shelly Kirn-Dean David and Sharon Slobodnik Alva Klooster Donald Klooster Elizabeth Klopcic Donald Klopcic Larry Kneeshaw Gerald and Tracy Kneeshaw

Julia Kraker David and Sallie Brinks Katie Huizenga Tom and Gerry Newby

David Kosten Michael DeBoer

Dorothy Leeser Patty Hall Sara Jewell Edward Peters Kent Ray Paul Richards

Donald and Patricia R. Kozal Karen Best

Charles Clinton Lewis Foundation Source

Donald R. Kozal Anne Kozal

Allan C. Lowe Allan and Barbara Lowe

Lee Koning ‘Stephen and Jane Doezema

37

Patricia R. Kozal James Best Joseph and Anne Marie Bialczak Harry and Dolores Bukala Brenda Chaffee Richard and Deborah Daniels Grand Valley Health Plan John and Ann Kamyszek Brian Kiliszewski Richard and Barbara Kiliszewski Lolayne Koukios Jacqueline Kozal James Kozal Kevin and Eveline Kozal Maxine Krolik Dennis and Diane Mikita Sue Ann Ondersma Gordon and Carol Peterman Cecilia Pius Patricia Rosengren Gregory and Julie Rosloniec Caroline Rusilowski Gerald Schneck Karen Schultze Al and Doreen Schwartz Barb Wessels Edmund Wila

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Michelle Marie Lunn Michelle Lunn Hope Foundation

Robert Mills Donald and Dorothy Far

John MacKeigan Paul and Charlene Fitzpatrick

Terry Nawrocki Timothy and Jennifer Nawrocki

Arlene Sabaitis Charles Sabaitis Phyllis Swarts West Side Community Council, Inc Mark and Kathy Woronko

Jessica Marcellino Marsha Beach Alfred and Catherine Brown Beth Byrne Michael and Kathy Dood Hanni Drake Mary Marcellino Vernon and Nancy Oosterhouse Esperanza Rencher Kathy Wyn

Karen Newell William Stewart

Frederick C. Page Richard and Patricia Cebelak

Mary Nichols Todd and Barbara Hart

Verna Paulik Alain Godeau and Mary Scanlan

Jane Nichols John Nichols

Robert Pearson Karen Kamerschen

Theodore A. Nicolette Eleanore Nicolette

Daniel F. Pelak Richard and Patricia Cebelak

Harry J. Nielsen Bill and Carol Burr Orson and Sharon Coe

Denise Picardat Brian Picardat Bethany Rainer

Dave Raab Pearl Clarke Paul and Bonnie Crumback Scott Dunn Joseph and Karen Griffith Ingeborg Hoppe Janet Johnson Joel and Melissa Kazy Mary Kugel John and Sandra Quick Eugene and Margaret Raab Peter and Katie Sattherwaite Arloa Schildroth Ray Stevens Donna Truax Diana Wales Al Weir

Zola Mae Noordyke Jacqueline Kozal

Mary J. Pillars Lisa Halbert

Loraine Rafferty Paul and Charlene Fitzpatrick

Esther Schafer Alan Shafer

Vito A. Oddo Josephine Sarullo

Ernie Popiel Joseph Popiel

Linda Randall Amy Randall

James and Char Schierbeek Jerry Broersma

Donald J. and Donna M. Oleniczak Steven and Juliana Wilkening

Larry Powers Dawn Anderson

Karen Randolph Cathy D. Mathews

Leona Powney Roy Freville

Barbara Ratuszny Michelle Andrew Steve Brenner Nancy Manning George and Carol Masselink Jon and Connie Meduna Jeffrey and Karri Ratuszny Mary Ellen Ratuszny Judy Rigsby Colleen Zielinski Roger and Karen Zimmerman

James Schmalz Donna Dodd Richard Liberatore Bernadette Meyer Holly Salas Leslie Schmalz Allen and Lynnette and Scott Judy Tykwinski Janet Verity Aleta Wells Jack and Sharon Wells Allen Wycoff

Florence McBrien Rob and Sherri McBrien Family Elizabeth McCaghy Paul and Charlene Fitzpatrick David McCarthy Kimberly McCarthy Robert McCoy Robert Hollman James McDonald Jean Swaney Mari Jo Meyer Elsa Dykema Marcia Ratliff Matilda Miles Homewatch Caregivers of West Michigan Susan R. Miller Jean Swaney Moose Mills Valerie Bomar

Vera Overholt Leo and Helen Boruta Janice Deverman Mary Ann Fox Carol Hale Donald and Ellen Herbig Darrell and Mary Huggins Joann Kasianowicz Suzanne Kozloski Kathy Kozminski Mark and Joan Malewitz Timothy Nelson Ellie Rossi

John Prins Joan Stuursma Russell W. Proos David and Sallie Brinks Janice Eckwielen Terry and Linda Otten Gary and Mary Proos John and Diane Proos Tim and Victoria Proos Ronald Redder

Patricia Rosengren Steelcase Inc. Maria Van Til

Leo Reardon Jim Jaynes

Christine S. Rees Sally Curtiss Elizabeth Rick Shirley Switek James Riekse Homewatch Caregivers of West Michigan David L. Rossi Anne Rossi Ken Rykse Heeren Bros, Inc Dwight W. Sawyer Jacquolyn Sawyer George Schachermeyer James and Carol Schachermeyer

Michael Schwark Kerry and Laurie Buettner Jane Magrady Guy and Laura Staples

Rusty Swaney Jean Swaney Steve and Sarah Swaney Family Tom and Sue Swaney Family

Ruth Ann Scripps Jennifer Barr

Margaret and Eugene Swanson Aspen Community Foundation Max Baker Timothy and Deborah Burbank Marjorie Cargill Kyran Cook and Kay Gfeller Michael and Elizabeth Cook Patrick and Valorie Cook Jason Dembeck and Sara Mackeigan Dembeck Tracy Denault Dan Hammersmith Paul and Jennifer Hanrahan Mary Hanrahan-Taube Steve and Brenda Kampfschulte Mary Koryto Suzanne MacKeigan Mary A. O’Rourke Steven and Susan Pachulski Garnet Runstrom Mary Stachowiak Donald and Gloria Sutton Margaret and Eugene and Swanson Joan Walsh Duffy Margaret Wind John and Amy Winger

Steve Sedlacek Jessi Sedlacek Chris Shaw Tom and Barb Shaw Robert G. Simpson Grace Simpson Donna Sivaraman Narayan Sivaraman Marie Smith R. Scott Smith Patrick and Helen Smyth Rich and Joan Kirsch Tobey Sorensen Terry TenBrink Harry Spearin Margaret Spearin Ryan Spike Carmen Spike

Karen J. Tanis Randy and Natalie Sluja

Charles Tutt Holly Dykstra Barbara Landolfi Michael Landolfi Donald and Joanne Liebenauer Patty Luoma Cecilia Pius Jay Van Andel Linda Lee Koert Nancy Van Andel Jay and Betty Van Andel Frank Padron Carol Van Dellen Rosemary Bennett Irene Callaway Lori Feenstra Kenneth and Dana Proffer Shores Rheumatology Patrick and Sandra Tierney Daniel and Betsey Tinkham Robert Van Dellen Gordon and Margaret Van Wylen Clifford Van Hoven Randy and JoAnn Van Hoven Bill Van Regenmorter Jack and Mary DeWitt Kenneth and Phyllis Dornbush Dorothy Verburg Rick Verburg

John Spruit Homewatch Caregivers of West Michigan

Daryl Ter Haar Patricia Ter Haar

Marlene Vis Lonnie Vis

Johnna Suttorp Robin Shotko

Adriana Termaat Paul and Charlene Fitzpatrick

Virginia Wade Donna Peavy

Chester Schut Clinton and Joanne Hop

Dorothy Suzio Heather Ridley

Max Thompson Fred Westdale

Rosemarie Ward Maria Ward

Jon Schutter Carol Schutter

Billy Swaney Jean Swaney

Tru Turkenburg Philip and Mary Ellen Bloem

John Wassenaak Ellen Doorn

Jerome Wassink Scott and Jennifer Groseclose

Herb Zeitter Shirley Zeitter

Jerry Weener William and Valorie Weerstra

Theresa Ann Zeman Henry and Bernice Zeman

Marian Westrate Gary Westrate Kathryn E. Whalen Michael Whalen Warren Wierenga Wayne and Mary Jo Beld Peter and Victoria Fifelski Timothy Gabrielse Jerry and Cheryl Glashower Mark and Robin Meyers Morgan Composting Northland Farms Glenna Wilde Brigade Fire Protection Brenda Young Nona Wirt Howard Wirt Margaret Witt North Kent Women’s Pool League Greg Wolf Steven Klotz William B. Wondergem James Collins Wilde Wood Susan Schwaiger John Yared William and Kathleen Colcord Eugene Yost Carole Yost

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“100% of your partnership goes directly to research and education to shape the future of disease treatments and therapies.”

– David Van Andel

–David Van Andel

PUR PLE COM M UNITY E VENT S

Purple Community is filled with individuals and organizations joining together in fun ways to offer hope, support, and real action against disease. From sports events to jeans days at work, your events raised more than $400,000 for research and science education in 2014.

Caledonia High School - Lacrosse Tournament Cascade Fellowship Church - Outing at the Kent County Conservation League Catholic Central High School - Football Game Cellar Brewing Company - Hops for Hope Christian Football League - Football Game

B-93 - Birthday Bash - Country Kicks Cancer - Fat Tuesday Gumbo Challenge

The Color Run - Purple Color Zone

Blue West Properties - Year-long Partnership Body by OH - Workout Nights Brix Corner Oven - Hops for Hope Buffalo Wild Wings - Alpine Give Back Night - Celebration Cinema Give Back Night - Downtown Grand Rapids Give Back Night

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Byron Center High School - Volleyball Game

Aquinas College - Hockey Game

Black River Tavern - Hops for Hope

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- Wyoming Give Back Night

Covenant Christian High School - Volleyball Game Cutlerville Days - Parade Davenport University - Men’s Lacrosse Game Detroit Public Schools - Football Games Detroit Red Wings - “Hockey Fights Cancer” Night Dr. Hannapel’s Dentistry - Fighting Cancer One Tooth at a Time Fundraising Campaign

Duncan Lake Middle School - Cancer Walk

Glow Run - Charity Partner

Gus Maker - Purple Community Team

DENYM - Henry & Belle Trunk Show

Grand Rapids Amateur Hockey Association - Coaches vs Coaches Game

Holiday Inn Grand Rapids - Purple Pillow Promotion

Eastern Floral - Breast Cancer Awareness Month Promotion Eights for Hope - Rowing Event

Grand Rapids Griffins - Hockey Game

HomeWatch CareGivers - Year-long Partnership - East Grand Rapids 4th of July Parade - Kennedy’s Floral Benefit Day

Evergreen Commons - Pedal for Purple

Grand Rapids Marathon - Race Participants

HopCat - Grand Rapids - Hops for Hope

Fifth Third River Bank Run - Race Participants

Grand Valley State University Pre-SOMA - Gail Easter Memorial Run - Momentum Dance Team Benefit Dance Competition

Hope College - Soccer Games

Grandville High School - Women’s Soccer Game - Women’s Tennis Match - Women’s Softball Game - Men’s Baseball Game - Men’s Lacrosse Game - Women’s Lacrosse Game - Purple Power Run honoring Alyssa Arends - Uccello’s Ristorante Pizzeria & Sports Lounge Give Back Week

H.T. Hackney Co. - Golf Outing

Flowerland - Putt-Putt Golf - Yoga in the Greenhouse Forest Hills Central High School - Basketball Game - Hockey Game - Quaker Steak and Lube Restaurant Give Back Night - RAMGER Lacrosse Tournament Forest Hills Northern High School - Basketball Games Fruitport High School - Cheer for A Cure Cheerleading Clinic Gezon Motors - Breast Cancer Research Fundraising Event

Grand Rapids Drive - Basketball Game

GRCC Police Academy A-Squad - Night at the Griffins Great Lakes Scrip Center - Year-long Partnership Greenville High School - Man Pageant

Hops at 84 East - Hops for Hope

Hudsonville High School - Volleyball Game Jaden James Brewery - Hops for Hope Jessie’s Ride for a Cure - Motorcycle Ride Joe’s Bar & Grill - Hops for Hope Kalamazoo Growlers - Baseball Game Kalamazoo Wings - Hockey Game

Kendall College of Art and Design - Bodies of Art Fashion Show Lakeside Camp Park - Cancer Awareness Weekend Lorrie Jaynes’ - 10 Year Cancer Survivorship Walk Mancino’s of Greenville - Parkinson’s Fundraiser Mari J. Meyer Pancreatic Cancer Trail Run for Hope - Arts and Carafes Painting Night - Main Street Pub Fundraiser - Peppino’s Charity Night - Russo’s of Kentwood Fundraiser McFadden’s Saloon - Hops for Hope The Meanwhile Bar - Hops for Hope Michelle Marie Lunn Hope Foundation - Golf Outing Michigan Blood - “Just One More” Blood Drive Michigan Sport Management Association - Sport Management Conference

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P U R P L E C O MMU N I T Y EVEN T S ( CONTINUE D)

Miedema Asset Management Group - Charity Auction Mike “The Barber” Classic - Golf Outing The Mitten Brewing Company - Hops for Hope Monica’s Cookies - Purple Cookie Promotion Northpointe Christian High School - Basketball Game O’Duffy’s Irish Pub - Hops for Hope Old Boys Brewing Co. - Guest Bartender Event Otsego Public Schools - Football Game - Cheerleading - Women’s Volleyball Game - Men’s Soccer Game - Women’s Swim Meet Outback Steakhouse - Grand Rapids - Walker Give Back Night - Grand Rapids Kentwood Give Back Night - Grandville Give Back Night Pigeon Hill Brewing Company - Hops for Hope Pinewood Middle School - Basketball Game 439 1

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Pulling for a Cure - Tractor Pull Pure Barre Grand Rapids - Pure Barre on the Blue Bridge presented by Lole Purple Community Leadership Academy Putt Out Cancer - Golf Outing The Pyramid Scheme - Hops for Hope Railside Golf Club - Ladies Golf Outing Reeths Puffer High School - Women’s Soccer Game Regal Investment Advisors - America’s Pastime Strikes Out Cancer Chicago Cubs Rooftop Event

SIGNATUR E SPE CIAL E V E NT SPONSORS South Christian High School - Baseball Game - Softball Game Springhill Suites Grand Rapids North - Private Tasting Event St. John’s High School - Soccer Game St. Thomas the Apostle - Volleyball Game Stella’s Lounge - Hops for Hope Symmetry Training and Fitness - Spin Classes Tapistry Brewing - Hops for Hope

Union High School - Volleyball Game United Soccer Athletes Club - Soccer Games United Soccer Athletes Club U10 Girls - Indoor Soccer Games Vision Source - “Eyeing a Cure” Fundraising Campaign WCHA Final Five Tournament - Hockey Games Wells Fargo Advisors, LLC - Jeans Day West Catholic High School - Basketball Game West Michigan Storm Soccer Club - Soccer Games

The Rehmann Group - Jeans Day

Team Troll - Osgood Brewing Co. Charity Night - Trail Run - Iceman Cometh Challenge

Rezervoir Lounge - Hops for Hope

Traverse City Beach Bums - Baseball Game

West Ottawa High School - Basketball Games - Hockey Game

Traverse City Central High School - Football Game

White Flame Brewing Company - Hops for Hope

Rockford High School - Basketball Game - Soccer Game - RAMGER Lacrosse Tournament Phil Rydel and Friends - Golfing Outing Saugatuck Brewing Company - Hops for Hope

Traverse City West High School - Football Game Tri Del Sol Triathlon - Race Participants Tupperware - Fundraising Party

West Michigan Whitecaps - Baseball Game

Yoga HEAT - Yoga Classes

Special Events are opportunities to celebrate our success and invest in the future. We are fortunate to have extraordinarily dedicated signature special event sponsors whose generosity provided more than $1 million for research and science education in 2014.

Blacklamb Bluewater Technologies Charles and Christine Boelkins

Dickinson Wright PLLC Dixon Interior Design

Buist Electric

DK Security

Stylist Allison Burr

Donald Baker Masonry, Inc.

C&G Newspapers

Durand Capital Partners

Calvin College

Dykehouse Photography

Heidi and Scott Campbell

East Grand Rapids Football

CARNEVALE

Eenhoorn LLC

Cascade Rental

Ellis Parking Company

Celebration Cinemas

Peter C. & Emajean Cook Foundation

Aquinas College

Custer, Inc.

First National Bank of Michigan

Artistry

Cygnus27

Frederik Meijer Gardens

Tony and Kathleen Asselta

Czech | Asset Management

Gary and Vicky Ludema

Desserts by Lori Detroit Red Wings

Betz Industries David and Jill Bielema

The Dick & Betsy DeVos Family Foundation The Douglas and Maria DeVos Foundation

Andy Holtgrieve Howard Miller Company Huizenga Group Ice Sculptures LTD Imperial Beverage

Joe and Dorethea Kennedy

Cumulus Media

Berends Hendricks Stuit Insurance Agency

Hopen Life Sciences

Ferris Coffee and Nut Company

Aon

BDO

Hope College

Kelley-Cawthorne

Mimi Cummings

Design 1 Salon Spa

Mills Benefit Group, A Lighthouse Company

Eurest

Amway Grand Plaza Hotel

Bar Divani

Herman Miller Cares

JB & Me

Crowe Horwath LLP

Deloitte

Miller Johnson

Ernst and Young

Amway

Bang Blowdry Bar

Kevan Hall

Mike and Sue Jandernoa

Love and Valeda Collins

Dear Prudence

The Steve Van Andel Foundation

Erhardt Construction

Amore Trattoria

Davenport University

Spectrum Health

Jana Hall

Michigan State University College of Human Medicine

Martin and Peggy Greydanus

Colliers International

The Steve & Kathryn Bandstra Foundation

David and Carol Van Andel

Special Events Rental

Eileen DeVries

Alma Machinery Co. Inc.

Autocam Medical

Six.One.Six

Metro Health Hospital

Great Lakes Scrip Center, LLC

Brush Studio

CityFlats Hotel CitySen Lounge

Meijer

The Richard & Helen DeVos Foundation

Fifth Third Private Bank

Gilmore Catering Gina’s Boutique GR Outdoor Grand Rapids Christian Football Grand Rapids Christian Schools

Kentwood Office Furniture Craig and Debra Kinney Al and Robin Koop Lake Michigan Credit Union

Modern Day Floral

Tassoni & Associates P.C.

Mike and Rachel Mraz

The Acorn Grille @ Thousand Oaks

Old World Olive Co. Kevin Paul

The Chop House

Pioneer Construction

The Crown Jewel Spa & Salon

Pitsch Companies Plastic Surgery Associates Preusser Jewelers Regal Investment Advisors Reserve Wine & Food RIZE

Leigh’s

Root Lowell Manufacturing

Leo’s

John and Therese Rowerdink

LPIT Solutions

Grand Rapids Symphony

McDonnell Investment Management Medawar Jewelers

Rowerdink Inc. San Chez, A Tapas Bistro Scott Christopher Homes Scott Group Custom Carpets Sheryl & Paul Haverkate

Dave and Beth Van Portfliet

Warner Norcross & Judd Wells Fargo Advisors Wells Fargo Bank Williams Kitchen & Bath Greg and Meg Willit

The Bengtson Center for Aesthetics and Plastic Surgery

Norris, Perné & French

Rockford Construction

Grand Rapids Griffins Grand Valley State University

Tapistry Brewery

Law Weathers

Lighthouse Insurance Group

Steelcase Inc.

MLive Media

Neiman Marcus

Van Eerden Foodservice Veolia Energy Grand Rapids

Standard Lumber Suburban Landscapes

Jeffery Roberts

Brad and Marilea Lightner

Standard Kitchen

Minds in Motion

Laura Mercier

Licari’s Restaurant

Robert and Susan Stafford

The Grand Rapids Griffins

Wilson Dental Care Wolverine Worldwide Women’s Lifestyle Magazine Aaron and Amanda Wong Wuskowhan Players Club

The Granger Group The I.C.N. Foundation The Local Epicurean The Northern Cross Foundation The Sharpe Collection The Veldheer, Long, Mackay & Bernecker Group of Merrill Lynch Wealth Management Thousand Oaks Golf Club Todd Wenzel Buick GMC Townsquare Media Tre Cugini Twisted Rooster US BANK

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LEAD E RSH IP TE A M

B OAR D AND COUNCIL M E MBERS

Left to right:

David Whitescarver Vice President and Chief Legal Officer Love Collins, III Vice President of Development, Communications and Marketing

Van Andel Institute Board of Trustees

Van Andel Research Institute Board of Trustees

Van Andel Education Institute Board of Trustees

Peter Jones, Ph.D, D.Sc. Van Andel Research Institute Research Director and Chief Scientific Officer

David Van Andel

John Kennedy

David Van Andel

James B. Fahner, M.D.

David Van Andel

James E. Bultman, Ed.D.

Chairman and Chief Executive Officer, Van Andel Institute

President and Chief Executive Officer, Autocam Corporation

Chairman and Chief Executive Officer, Van Andel Institute

Chief of Hematology/ Oncology at DeVos Children’s Hospital in Grand Rapids, Michigan

Chairman and Chief Executive Officer, Van Andel Institute

Former President, Hope College

Mark Meijer

Ralph Hauenstein

President of Life E.M.S. Ambulance

(Emeritus Trustee), President, Hauenstein Enterprises

George Vande Woude Ph.D.

David Van Andel Chairman and Chief Executive Officer Steven J. Triezenberg, Ph.D. Director of Van Andel Education Institute, President and Dean of Van Andel Institute Graduate School Jana Hall Chief Operations Officer

(Not pictured)

Distinguished Scientific Fellow, Van Andel Research Institute

Ralph Weichselbaum, M.D. Professor & Chairman of the Department of Radiation and Head of the Ludwig Center for Metastasis Research at The University of Chicago

Juan R. Olivarez, Ph.D. President, Aquinas College

Donald W. Maine Former President, Davenport University (Not pictured)

Gordon L. Van Harn, Ph.D. Emeritus Provost and Professor of Biology, Calvin College

(Not pictured)

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BOARD AND C O U N C IL M E M BE RS (CONTINUED)

VA N A N D E L I N S T I T U T E ’ S B O A R D O F G O V E R N O R S A P P O I N T S C O - C H A I R S T I M L O N G A N D V I C K Y L U D E M A

“We are all touched by cancer, Parkinson’s or heart disease, and Van Andel Institute is ‘all-in’ when it comes to addressing these human health issues in the lab or developing dynamic science education initiatives to inspire young minds. We believe that the work being done at the Institute has the power to directly impact the health of current and future generations. ” Van Andel Institute’s Board of Governors benefits the Institute financially and serves as ambassadors who share the Institute’s mission, vision and accomplishments with potential donors and community partners. Business leaders Tim Long and Vicky Ludema were appointed co-chairs in 2014 and bring with them years of experience in management, finance and philanthropy.

Tim Long is a Managing Director and Global Institutional Consultant for Merrill Lynch. He works with institutions and high net worth families around the country. He was named a top advisor by both Barron’s magazine and the Financial Times. Long has worked with Merrill Lynch since 1994 following a successful career with Mobil Oil in New York.

Long is passionate about how business and philanthropy can drive innovation and discovery at Van Andel Institute.

– Tim Long and Vicky Ludema

Vicky Ludema is an accomplished business professional with more than 30 years of experience in consulting. Ludema has been involved in business management for 17 years with Crowe Horwath LLP and is a Director in the Grand Rapids, Michigan office. Ludema’s experience also includes positions at IBM and Wang Laboratories. In addition to her work with the Board of Governors, Ludema serves on planning committees that help organize the Institute’s successful fundraising events.

Through their work on the Board of Governors, Long and Ludema are confident that they will continue to create lasting partnerships in the business and philanthropic community, and play an active role in the Institute’s forward momentum.

VA N A N D E L I N S T I T U T E ’ S J U N I O R B O A R D C E L E B R AT E S F I V E Y E A R S O F S E R V I C E J-BOARD RESPONSIBILITIES AND BENEFITS

RESPONSIBILITIES AND BENEFITS OF JOINING VAN ANDEL INSTITUTE’S BOARD OF GOVERNORS

“We are proud of the work Van Andel Institute is doing in the fields of biomedical research and science education, and it is an honor to support work that has the potential to positively impact the health and well-being of our community, region and the world.” –­ Rachel Mraz and Heidi Campbell

• Annual commitment of $1,000; • Serve as ambassadors and advance the mission and vision of Van Andel Institute (VAI) in the local and national community; • Remain current on research and educational advancements that are underway at VAI; • Attend special events, lunches and lectures when possible; • Provide perspectives and ideas aimed at advancing Van Andel Institute’s vision and development activities; • Serve as ambassadors in the community by engaging with new prospects and encouraging them to join.

THE BOARD OF GOVERNORS WILL HAVE A MINIMUM OF TWO INVITATION LECTURES AND ONE SOCIAL ENGAGEMENT EACH YEAR.

Events include: • 2 complimentary tickets to the invitation-only Carol Van Andel Angel of Excellence Dinner & Award Presentation; • 2 complimentary tickets to Hope on the Hill;

Van Andel Institute’s J-Board celebrated its five-year anniversary in 2014. Since its inception, young professionals from a variety of backgrounds have joined the J-Board to play an active role in shaping the Institute’s future. The J-Board has hosted fundraising events, luncheons and scientific speaking engagements, providing an opportunity for networking, fundraising and activism. Members of the J-Board serve as brand ambassadors for the Institute, and the group continues to provide funding and support for the Institute’s biomedical research and science education initiatives. Members support the Institute with a $250 annual contribution and provide outreach to individuals who are not already associated with the Institute.

Rachel Mraz, co-chair of the J-Board, helped create the concept in 2009 in order to involve talented young professionals with the Institute’s mission. Mraz, Wealth Management Advisor and Senior Vice President-Wealth Management at Merrill Lynch, works with individuals and foundations to define financial goals and implement investment strategies. Mraz’s professional experience and leadership has developed the program into a significant philanthropic force. Heidi Campbell serves as co-chair with Mraz, and her experience in sales, philanthropy, charitable work and mentoring has helped introduce the J-Board to a new, vibrant group of leaders.

• Become the next generation of ambassadors by sharing Van Andel Institute’s (VAI) mission with friends and acquaintances and grow J-Board membership by 5% annually; • Provide outreach to individuals who may not otherwise connect to the Institute through four event engagements per year. Additionally, all members will invite two business associates to the annual J-Board dinner each year; • Support VAI financially with a donation of $250 per year per person; • Learn firsthand about the cutting-edge biomedical research and science education by attending lectures and luncheons sponsored by the J-Board; • Attend J-Board Ambassadors events that are networking opportunities with peers; • Receive news and information about annual VAI events on a regular basis; • Receive invitations to annual health science forums and luncheons throughout the year; • Receive two complimentary tickets to VAI’s Winterfest Celebration held every February; • Receive recognition on VAI’s website and in VAI’s annual report.

• Han Mo Koo Memorial Lecture; • Daniel Nathans Memorial Lecture; • Lunch & Learns with J-Board Members.

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VAN ANDEL INSTITUTE

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BOARD AND C O U N C IL M E M BE RS (CONTINUED)

Hope on the Hill Board of Governors

J-Board Ambassadors

THANK YOU, BOARD OF GOVERNORS

THANK YOU, J-BOARD MEMBERS

As members of the Van Andel Institute Hope on the Hill Board of Governors, your support of the Institute helps advance our efforts to improve the health and enhance the lives of current and future generations. Thank you for being our partners, serving as our ambassadors, and contributing significantly to our success.

As J-Board members, you are leaders who exhibit the power of young professionals to make a difference.

We appreciate the energy and dedication you bring to the Institute. Thank you for your vision and your friendship in our efforts to fight disease and advance our mission every day.

Co-Chairs: Tim Long Vicky Ludema Martin and Sue Allen Ray and Alice Andrews James and Shirley Balk Nancy Batts Chuck and Chris Boelkins Jim and Donna Brooks James and Martha Bultman Gerald and Suzanne Callahan John and Marie Canepa Mike and Kim Carnevale President Jimmy Carter Love and Valeda Collins Dave and Karen Custer Robert and Carol DeVilbiss Daniel and Pamella DeVos Dick and Betsy DeVos Douglas and Maria DeVos Richard and Helen DeVos Jim and Gail Fahner Tim and Laura Feagan

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John and Melynda Folkert

Hank and Liesel Meijer

David and Judy Frey

Lena Meijer

Dan and Lou Ann Gaydou

Mark and Mary Beth Meijer

Gene and Tubie Gilmore

Jack H. Miller

Gary and Pam Granger

Jamie Mills

Martin and Peggy Greydanus

Louis and Nancy Moran

Jana Hall

Mark and Elizabeth Murray

Ralph Hauenstein

Michael and Michelle Van Dyke Gordon and Mary Van Harn Gordon and Margaret Van Wylen George and Dot Vande Woude

Co-Chairs: Heidi Campbell Rachel Mraz Zeke and Natalia Alejos Jennifer Baldini Lindsay Benedict

Tim and Denise Myers

Stuart and Nelleke Vander Heide

John and Gwen Hibbard

Juan and Mary Olivarez

Ted and Joan Vanderveen

Scott and Heidi Campbell

Dirk and Victoria Hoffius

Donald and Ann Parfet

Linda Jo Carron

Earl and Donnalee Holton

Carol Rottman

David and Anne-Lise Whitescarver

Bea Idema

John and Therese Rowerdink

José and Sue Infante

Margaret Ryan

Win and Kyle Irwin

Peter and Joan Secchia

Bo and Jennifer Fowler

Michael and Sue Jandernoa

Budge and Marilyn Sherwood

Nicole Haglund

John and Nancy Kennedy

Brent and Diane Slay

Michael Herring

Craig and Debra Kinney

Robert and Susan Stafford

Wilbur and Sharon Lettinga

Duke and Sue Suwyn

Mark Holtvluwer and Wendy Parr Holtvluwer

Ray Loeschner

Marilyn Titche

Tim and Kimberly Long

Steve and Laura Triezenberg

Gary and Vicky Ludema

Dave and Carol Van Andel

Donald and Kathleen Maine

Steve Van Andel

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Scott and Rebecca Wierda Liam Sullivan and Linda Zarzecki

Brandon Bissell

Natalie Cleary Matthew Cook Aaron and Afton DeVos

Van Andel Research Institute Board of Scientific Advisors

Van Andel Research Institute External Scientific Advisory Board

Michael S. Brown, M.D.

Tony Hunter, Ph.D.

Tony Hunter, Ph.D. - (Chair)

Howard J. Federoff, M.D., Ph.D.

Rudolf Jaenisch, Ph.D.

Paul J. Thomas Professor of Genetics and Director of the Jonsson Center of Molecular Genetics, University of Texas Southwestern Medical Center – Dallas

American Cancer Society Research Professor; Professor in the Molecular and Cell Biology Laboratory, Salk Institute; Director, Salk Institute Cancer Center

Professor, Molecular and Cell Biology Laboratory; American Cancer Society Professor; Renato Dulbecco Chair; Director, Salk Institute Cancer Center

Executive Vice President for Health Sciences; Executive Dean of the School of Medicine, Georgetown University

Professor of Biology, Massachusetts Institute of Technology (MIT); founding member of the Whitehead Institute for Biomedical Research at MIT

Patrick Kane

Richard Axel, M.D.

Philip A. Sharp, Ph.D.

Marie-Francoise Chesselet, M.D., Ph.D.

Michael Lomonaco

Professor of Neurosciences, Columbia University

Professor of Biology, Massachusetts Institute of Technology; Head of the Cancer Center at MIT; Founder of Biogen Corporation

Charles H. Markham Professor of Neurology; Distinguished Professor of Neurology and of Neurobiology, Reed Neurological Research Center

Alyssa Ludema Geoff Ludema Casey McDonald

Joseph L. Goldstein, M.D.

Mike and Rachel Mraz

Chairman of the Department of Molecular Genetics, University of Texas Southwestern Medical Center – Dallas

Matt Osterhaven Deidre Remtema

Professor of Medicine; Jerry W. and Peg S. Throgmartin Professor of Oncology, Indiana University School of Medicine Kristian Helin, Ph.D. Director, Biotech Research & Innovation Centre (BRIC); Professor, Faculty of Health Sciences, University of Copenhagen

Charlie Rowerdink Lindsay Slagboom

Theresa Ann Guise, M.D. Max S. Wicha, M.D. Distinguished Professor of Oncology; Professor, Department of Internal Medicine; Founding Director, University of Michigan Comprehensive Cancer Center

Van Andel Education Institute Advisory Council

Van Andel Institute Graduate School Board of Directors

Kyle Van Andel

James N. Boelkins, Ph.D.

Leanne Van Dyk, Ph.D.

Michael J. Imperiale, Ph.D.

Daniel VandenBosch

Former Provost of Hope College

Dean and Vice President of Academic Affairs and Professor of Reformed Theology, Western Theological Seminary

Professor and Associate Chair Department of Microbiology & Immunology, University of Michigan Medical School

Christopher Spain Charity Taatjes Trevor TenBrink

Alison Waske Sutter

Jennifer Humphries

Nathaniel Wolf

Brandi Huyser

Brian and Courtney Yarch

Eric Jones

Scott and Megan Zubrickas

Lynn M. Matrisian, Ph.D., M.B.A. Vice President, Scientific & Medical Affairs, Pancreatic Cancer Action Network

Carol Van Andel Executive Director, David and Carol Van Andel Foundation

Thomas J. Haas, Ph.D. President, Grand Valley State University Gordon L. Van Harn, Ph.D.

Joe Krajcik, Professor

Pamela G. Kidd, M.D.

James B. Fahner, M.D.

Department of Teacher Education, Michigan State University

Medical Director, Hematology & Flow Cytrometry Laboratories Spectrum Health & Helen DeVos Children’s Hospital

Chief of Hematology and Oncology, Helen DeVos Children’s Hospital

Emeritus Provost and Professor of Biology, Calvin College, Former VAEI Director

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INSIDE BACK COVER

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