Reuniao ibu 2008 capa

GOVERNO DO ESTADO DE SÃO PAULO SECRETARIA DE ESTADO DA SAÚDE COORDENADORIA DE CIÊNCIA, TECNOLOGIA E INSUMOS ESTRATÉGICOS DE SAÚDE INSTITUTO BUTANTAN SÃO PAULO - SP BRASIL

Memórias do Instituto Butantan

X Annual Scientific Meeting

Volume 65 December 2008

São Paulo, SP – Brazil 2008 ISSN 1982-3045

INSTITUTO BUTANTAN Board of Counselors and Divisions Director Otavio Azevedo Mercadante Directing Council Otavio Azevedo Mercadante (President) Adib Domingos Jatene Erney Plessmann de Camargo Henrique Moisés Canter Hernan Chaimovich Guralnik Hisako Gondo Higashi Ivo Lebrun Jorge Elias Kalil Filho Luiz Rodolpho Raja Gabaglia Travassos Paulo Marchiori Buss Paulo Roberto Teixeira

Scientific Division Director: Ivo Lebrun Research Council Ana Marisa Chudzinski-Tavassi Ana Maria Moura da Silva Denise Vilarinho Tambourgi Marcelo de Franco Maria de Fátima Domingues Furtado Norma Yamanouye Paulo Lee Ho Solange Maria de Toledo Serrano Technological and Production Division Director: Hisako Gondo Higashi Production Council Ana Maria Moro Elisabeth Christina Nunes Tenório Olga Kikue Akimura Rosalvo Guidolin Sally Muller Affonso Prado Cultural Division Director: Henrique Moisés Canter Cultural Council Benedito Carlos Prezoto Fan Hui Wen Giuseppe Puorto Orlando Garcia Ribeiro Filho Rosana Martins Vânia Dalle Piagge

Organizing and Scientific Committee for the X Annual Scientific Meeting of Instituto Butantan Rute Maria Gonçalves de Andrade - President Denise Vilarinho Tambourgi - Vice-president Alessandra Fernandes Bizerra Angela Silva Barbosa Fernanda Calheta Vieira Portaro Fernanda Faria Giuseppe Puorto Inácio de Loiola Meirelles Junqueira Azevedo Ivone Kazuko Yamaguchi Maria Cristina Breno Sandra Coccuzzo Sampaio Waldir Pereira Elias Junior Executive Supporting Committee Giselle Pidde Queiroz Michele Silva de Barros Paula Luize Burckhardt Patrícia de Souza Santos Rafaella Marino Lafraia Rosana de Fátima Shoji Collaborators Antônio Carlos Orlando Ribeiro da Costa Elaine Rodrigues Hana Suzuki Henrique Moisés Canter Ida Sigueko Sano Martins Liana Maria Moretti Maria Letícia Righetti Maria Teresa Ghuiro Valentini Naomi Enoki Ricardo Braga de Souza Roberto Henrique Pinto Moraes Sávio Stefanini Sant’Anna Sérgio Marcello Humantschuk Teresa Eiko Kawabata Tiago de Paula Oliveira Vânia Dalle Piagge English Reviewer: Albert Leyva www.english-enhanced.com (al_leyva@yahoo.com) Acknowledgments Cultural Division Administration Division Engineering Division Biological Museum Team Informatics Section Fundação Butantan Financial Support Instituto Butantan Fundação Butantan

EDITORIAL COMMITTEE Editor-in-Chief : Gonçalves-de-Andrade, Rute Maria Associate Editors: Tambourgi, Denise Vilarinho; Portaro, Fernanda Calheta Vieira; Faria, Fernanda; Elias Júnior, Waldir Pereira Chief Librarian: Silva, Lindalva Santana da Assistant Reviewer: Albert Leyva Support: Instituto Butantan and Fundação Butantan Address: Biblioteca, Instituto Butantan Av. Vital Brazil 1500, 05503-900, São Paulo-SP, Brazil Phone: +55 11 3726-7222, Extension: 2129/2117 Fax: +55 11 3726-1505 E-mail: bibliobut@butantan.gov.br Eletronic page: www.butantan.gov.br

Memórias do Instituto Butantan (Secretaria de Estado da Saúde).

São Paulo, SP, Brasil, 1918 - 1990, 52 (Supl. 1-3) Em apenso, a partir de 1990, 52 (3): BOLETIM DE BIOTECNOLOGIA 1991, 53 (1) (Supl. 1, 2) 1992, 54 (1, 2) 1993, 55 (1, 2,) (Supl. 1) 1994-1995, interrompido 1996, 56 bienal, nova forma 1998, 57 bienal 2001, 58 bienal 2002, 59 bienal 2003, 60 anual 2005, 61 anual 2005, 62 anual 2006, 63 anual 2007, 64 anual, CD-ROM 2008, 65 anual, CD-ROM

ISSN 1982-3045

EDITORIAL In its 65th volume, “Memórias do Instituto Butantan” continues to present an overview of the diverse activities carried out at Instituto Butantan, based on the scientific program and abstracts of the X Annual Scientific Meeting. This meeting, whose theme is “ Scientific Research and Legislation: paths, detours and perhaps a confluence” is an initiative of the Division for Scientific Development, and it involves all the divisions of the Institute.

Through five round tables and discussions will be held on questions concerned to the interface between Legislation and Scientific research.

The event entails too three poster sections, scientific awards in four categories (scientific initiation, FUNDAP, master and doctoral) and two special sections about the Memories of Butantan Institute.

The posters to be presented in the X Annual Scientific Meeting are representative of the different research areas being developed in the Institution, such as: Venom and envenomation, Microorganisms and vaccines, Cellular biology and genetics, Animal biology, Science diffusion. The best posters presented by undergraduate, graduate, Master’s and Ph.D. Students will be awarded with Instituto Butantan Prize. On the whole, we hope this issue provides an impressive overview of the diverse activities being carried out at Butantan Institute in 2008.

Rute Maria Gonçalves de Andrade Editor-in-Chief Ivo Lebrun Divisão de Desenvolvimento Científico

X Annual Scientific Meeting of Instituto Butantan December 03 – 05, 2008 Scientific Research and Legislation: paths, detours and perhaps a confluence Scientific program Wednesday

12/03/2008

8:00 h

Poster Session I Venom and envenomation Microorganisms and vaccines Others PIBIC

09:00 – 09:20 h

Opening Session

09:20 – 10:20 h

Special Session Descendants of the Rising Sun in Instituto Butantan – Trodden paths

10:20 – 10:35 h

Coffee break

10:35 – 12:00 h

10:35 – 10:55 h 10:55 – 11:15 h 11:15 – 11:35 h

Round Table I Ethical and legal issues concerning scientific research with laboratory animals Coordinator: Denise Vilarinho Tambourgi, Laboratório de Imunoquímica, IBu Participants Marcel Frajblat – COBEA Regina Pekelmann Markus - USP Octávio Augusto França Presgrave - FIOCRUZ

11:35 – 12:00 h

Discussion

12:00 – 13:00 h

Lunch interval

13:00 – 15:00 h

Poster Session I

15:00 – 17:30 h

Young Scientist Award Award Committee Mário Tyago Murakami - LNLS Marcelo Damário Gomes - FMRP, USP Martin Hernan Bonamino - INCA

15:00 – 16:00 h

Scientific Initiation Award Coordinator: Yara Cury - Laboratório de Fisiopatologia, IBu

16:00 – 16:30 h

Coffee break

16:30 – 17:30 h

FUNDAP Award Coordinator: Ivo Lebrun - Laboratório de Bioquímica e Biofísica, IBu

Thursday

12/04/2008

8:00 h

Poster Session II Microorganisms and vaccines Cellular biology and genetic Animal biology Education and scientific dissemination Others FUNDAP

09:00 – 10:20 h

9:00 – 9:20 h 9:20 – 9:40 h 9:40 – 10:00 h

Round Table II Legal questions about intellectual property Coordinator: Fernanda Faria, Laboratório de Bioquímica e Biofísica, IBu Participants Maria Celeste Emerick - FIOCRUZ Jorge Taveira Samaha - ANVISA Vahan Agopyan - Secretaria de Desenvolvimento do Estado de São Paulo

10:00 – 10: 20 h

Discussion

10:20 – 10:35 h

Coffee break

10:35 – 12:00 h

10:35 – 10:55 h 10:55 – 11:15 h 11:15 – 11:35 h

Round Table III Genetically modified organisms: legislation and ethics Coordinator: Inácio L. M. Junqueira Azevedo, Centro de Biotecnologia, IBu Participants Walter Colli - USP/CTNBio Wim Degrave - FIOCRUZ Pablo Rubén Mariconda - USP

11:35 – 12:00 h

Discussion

12:00 – 13:00 h

Lunch interval

13:00 – 15:00 h

Poster Session II

15:00 – 17:30 h

Young Scientist Award Award Committee Célia Regina Ribeiro da Silva Carlini - UFRGS Marilis do Valle Marques – USP Wilmar Dias da Silva - UENF

15:00 – 16:00 h

Master Award Coordinator: Toshie Kawano - Laboratório de Parasitologia, IBu

16:00 – 16:30 h

Coffee break

16:30 – 17:30 h

Doctoral Award Coordinator: Ida S. Sano Martins - Laboratório de Fisiopatologia, IBu

Friday

12/05/2008

8:00 h

Poster Session III Venom and envenomation Microorganisms and vaccines Cell biology and genetic Animal biology

09:00 – 10:20 h

Round Table IV Access to genetic patrimony: bioprospection and access to traditional knowledge in a mega diverse country Coordinator: Maria Cristina Breno, Laboratório de Farmacologia, IBu Participants Carla Michely Yamaguti Lemos -CGEN/MMA Eliana Rodrigues - UNIFESP Nadja Maria Lepsch da Cunha Nascimento - INPA

9:00 – 9:20 h 9:20 – 9:40 h 9:40 – 10:00 h

10: 00 – 10: 20 h Coffee break 10:20 – 10:35 h

Interval

10:35 – 12:00 h

10:35 – 10:55 h 10:55 – 11:15 h 11:15 – 11:35 h

Round Table V Brazilian biodiversity: legislation on scientific research in conservation units, collection of biological material and scientific collection Coordinator: Rute Maria Gonçalves de Andrade, Laboratório de Imunquímica, IBu Participants Otavio Maia - Instituto Chico Mendes de Conservação da Biodiversidade/MMA Carlos Roberto Brandão – Museu de Zoologia, USP Carlos Henrique Franciscon - INPA

11:35 – 12:00 h

Discussion

12:00 – 13:00 h

Lunch interval

13:00 – 15:00 h

Poster Session III

15:00 – 15:30 h

Coffee break

15:30 – 16:00 h

IV Photograph Award

16:00 – 16:30 h

Ten years of the Annual Scientific Meeting of Instituto Butantan Coordinator: Alessandra Fernandes Bizerra, Museu de Microbiologia, IBu

16:30 - 17:30 h

Young Scientist Award

17:30 h

Closing Session