Successful Obstetrical Management of over 100-days Interval between Twin Delivery Effect of Delaying FET on Pregnancy and Live Birth Rates Preimplantation Genetic Screening and Diagnosis Various Techniques of Embryo Selection in ART Combination of Metformin+Letrozole is more Effective in Improving Reproductive Outcomes Impact of GnRH Agonist and Antagonist on Human Oocytes and Early Embryos Role of Medroxyprogesterone Acetate (MPA) in Women with Endometriosis undergoing IVF Clinical Practice Guidelines: Pregnancy Care 2018
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HIGHLIGHTS
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PREFACE
CASE STUDY
CONTENTS
1 3 IMAGE OF THE MONTH
4 5 7
CONFERENCE CALENDER
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14 QUIZ
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Contributed by:
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25–35 days
35
Patients (%)
30 25
50–70 days 33.2 26.8
20
27.5 21.5
15 10 5 0 Pregnancies
Live births
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Methods aCGH
Complexity
Duration (h)
Medium
~12
Abnormalities detected l l
SNP microarray
High
qPCR
Low
Up to 72
l l
l
Whole chromosome aneuploidy Parental origin Translocations
l
l
Whole chromosome aneuploidy
l
l l
4
Whole chromosome aneuploidy Translocations
Limitations
l
l
NGS
High
<24
l l l l
Whole chromosome aneuploidy Mosaicism, mitochondrial copy number Single-gene disorders Translocations
l
False positives Unable to detect mosaicism
Resolution Medium
Inability to detect balanced chromosomal rearrangements Inability to detect mosaicism
High
Not designed to detect segmental aneuploidy Unable to detect mosaicism or translocations
Low
Limited ability to detect balanced chromosome translocations
High
aCGH=Comparative genome hybridization; SNP=Single nucleotide polymorphism; qPCR=Quantitative polymerase chain reaction; NGS=Next-generation sequencing.
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F e Flash EMBRYO SELECTION TECHNIQUE Contributed by:
Nitiz Murdia
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# of blastocysts
% normal embryos Egg donors (%)
<35 years (%)
35–37 years (%)
38–40 years (%)
41–42 years (%)
>42 years (%)
1–3
58
61
51
39
22
13
4–6
62
60
52
38
23
17
7–10
65
62
51
36
21
14
>10
68
63
55
37
25
n/a
N=4,747 cycles and 29,803 embryos, up to 12/2013 Source: Ata, Munne et al. (2012) Reprod Biomed Online and unpublished data.
CONFERENCE CALENDER
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Patients (%) 0
5
10 15 20 25 30 35 40 45 Antagonist group
Agonist group
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Small sample size
12
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