Aluminum-chassis smartphones. Vulcanized rubber tires. Non-toxic sutures that dissolve in the body. Throughout the scientific world and beyond, progress often hinges on the right material for the right job. In this month's Materials Science issue, we look at examples of materials making a difference across a wide spectrum of applications, from prosthetics ("Prosthetic Progress") to athletic shoes ("Crossing the Line"). We also look at materials through the lens of hobbyists, from one Palo Alto High School student's 3D-printing business ("Fine Prints") to the auto shop's use of a plasma cutter (see Cover).