Institute of Bioengineering and Nanotechnology Annual Report 2006
Established in March 2003, the Institute of Bioengineering and Nanotechnology (IBN) is one of 7 biomedical research institutes under Singapore’s Agency for Science, Technology and Research (A*STAR). It’s mission is to: Conduct innovative research and create intellectual properties in these emerging fields, attracting topnotch researchers and business partners to Singapore.
Annual Report 2006
provide international leadership in establishing a broad knowledge base in bioengineering and nanotechnology.
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Cover Photo Microfluidic cartridge for automated biosample preparation and disease diagnostics
play an active role in technology transfer and spinning off small companies, linking our research institute and industrial partners to other global institutions.
foster an exciting, multidisciplinary research environment for the training of students and young researchers at the frontiers of bioengineering and nanotechnology.
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Contents
02 executive director’s message
IBN Leadership
21 Intellectual Capital
57 INDUSTRIAL CAPITAL
65 HUMAN CAPITAL
71 RESEARCH EXPENDITURE
Annual AnnualReport Report2006 2006
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Annual Report 2006
“...as we strive to fulfill our vision of becoming a world-class research institute, we will continue to foster a vibrant and collaborative research environment, and organize more platforms for the exchange of ideas and expertise with academia, industry and hospitals�
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The Nanos in Biopolis, Singapore
Executive Director’s Message
From April 2006 to March 2007, we received 12 international and local awards for our research, and published 101 papers in scientific journals and conference proceedings, including 33 papers in highimpact factor journals. IBN researchers had also been invited to present 56 keynote lectures and seminars, and presented 44 conference papers. Our efforts at integrating science, engineering and medicine to develop new approaches and novel technology platforms for biomedical applications led to 132 new patent applications during the last fiscal year. We have also launched spin-off companies and a major licensing deal to commercialize our technologies.
minimum duration of 4 weeks to 624 since the YRP was launched. Over 13,600 students and teachers from 171 schools have participated in various YRP activities since its inception in 2003. Our excellent performance in FY2006 would not have been possible without the hard work and dedication of our staff, who have been recruited from top institutions worldwide. In the year ahead, as we strive to fulfill our vision of becoming a worldclass research institute, we will continue to foster a vibrant and collaborative research environment, and organize more platforms for the exchange of ideas and expertise with academia, industry and hospitals. By building on our talent and expertise, we hope to make a significant impact globally through exciting research breakthroughs and intellectual properties in bioengineering and nanotechnology.
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IBN continued to create an impact internationally through our research efforts during the last financial year.
IBN’s Youth Research Program (YRP), a strategic initiative to nurture future generations of researchers, continued to expand its reach in FY2006 through Open Houses, short courses, workshops, career talks and research attachments. A total of 202 secondary school, junior college and polytechnic students and teachers, as well as undergraduates participated in research attachments at IBN last year. This brings the number of students and teachers who have been on full-time research attachment with the Institute for a
Professor Jackie Y. Ying Executive Director Institute of Bioengineering and Nanotechnology
Annual Report 2006
The IBN Seminar Series hosted seminars and short courses by 43 renowned experts from leading institutions worldwide. We also continued to reach out to the international community by hosting visits from 98 companies, academic institutions and government delegations. Our outreach efforts resulted in the establishment of 10 new joint projects with A*STAR research institutes, and local and international universities, as well as 8 new collaborations with clinical researchers and industrial partners last year.
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Annual Report 2006
IBN Leadership
Fibrous scaffolds for tissue engineering
Organization Structure
RESEARCH
DIRECTOR, ADMINISTRATION Noreena AbuBakar
Delivery of Drugs, Proteins and Genes Cell and Tissue Engineering
Youth Research Program (YRP)
Artificial Organs and Implants
Nidyah Sani, Coordinator
Pharmaceuticals Synthesis and Nanobiotechnology Medical and Biological Devices
Administration
Bioimaging and Biosensing
Janti Rustam, Head
Prof Jackie Y. Ying, Executive Director
Corporate Communications
Dr Francis Tay, Group Leader
Nidyah Sani, Head
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EXECUTIVE DIRECTOR Prof Jackie Y. Ying
Dr Shu Wang, Group Leader Dr Yi-Yan Yang, Group Leader
HUMAN RESOURCE
Dr Hanry Yu, Group Leader
Amanda Wong, Assistant Head
Dr Namyong Kim, Team Leader
Sor Leng Chua, Assistant Head
Dr Rachel Kraut, Team Leader Dr Motoichi Kurisawa, Team Leader Dr Runsheng Ruan, Team Leader Dr Karl Schumacher, Team Leader Dr Andrew Wan, Team Leader Dr Hsiao-hua (Bruce) Yu, Team Leader Dr Yugen Zhang, Team Leader Dr Lang Zhuo, Team Leader
Finance Joanne Choy, Head Information Technology Kok Hua Lim, Head Business Development Tieh Ling Koh, Assistant Head Procurement
TECHNICAL SUPPORT FACILITIES Shariff Arshad, Head SAFETY Adam Tham, Safety Officer
Christine Koh, Assistant Head
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Dr Su Seong Lee, Team Leader
Management
Annual Report 2006
Professor Jackie Y. Ying Executive Director IBN
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Executive Director Prof Jackie Y. Ying was appointed in March 2003 to spearhead IBN. Besides overseeing the overall operations at IBN, Prof Ying is also a Senior Group Leader. She was a Professor of Chemical Engineering at Massachusetts Institute of Technology between 1992 and 2005. Prof Ying has received a number of awards, including the American Ceramic Society Ross C. Purdy Award, David and Lucile Packard Fellowship, Office of Naval Research and National Science Foundation Young Investigator Awards, Camille Dreyfus Teacher-Scholar Award, American Chemical Society Faculty Fellowship Award in Solid-State Chemistry, TR100 Innovator Award, and American Institute of Chemical Engineers Allan P. Colburn Award. She was named a World Economic Forum Young Global Leader, and is currently the youngest member of the German Academy of Natural Scientists, Leopoldina.
Noreena AbuBakar Director IBN
Director Noreena AbuBakar is in charge of IBN’s Administration, which comprises of Corporate Communications, Human Resource, Finance, Procurement, Information Technology, and Business Development. She also assists Prof Ying in key initiatives, including recruitment drives and strategic planning. Noreena established IBN’s Youth Research Program (YRP) in October 2003, and serves as the Chair of YRP. To date, over 13,600 students and teachers from 171 schools and tertiary institutions have participated in the YRP.
Scientific Advisory Board
IBN’s current SAB members include Professors Kenneth A. Smith (Chair) from Massachusetts Institute of Technology, Galen D. Stucky (Co-Chair) from University of California, Santa Barbara, Myron Spector from Harvard Medical School and Brigham and Women’s Hospital, Klavs F. Jensen from Massachusetts Institute of Technology, and Viola Vogel from ETH Zürich. Prof James R. Heath from California Institute of Technology and University of California, Los Angeles, stepped down as SAB member, after he accepted his joint appointment as Senior Group Leader at IBN. Prof Vogel accepted her SAB appointment in January 2007. Professor Kenneth A. Smith Chair Massachusetts Institute of Technology
Professor Galen D. Stucky Co-Chair University of California, Santa Barbara
Professor Klavs F. Jensen Massachusetts Institute of Technology
Professor Viola Vogel ETH Zürich
Professor James R. Heath California Institute of Technology and University of California, Los Angeles
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Professor Myron Spector Harvard Medical School and Brigham and Women’s Hospital
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IBN held its 4th Scientific Advisory Board (SAB) Meeting on September 8-9, 2006, in Santa Barbara, USA, where IBN Group and Team Leaders shared the progress of their research projects with the board members. The 5th SAB meeting was held in Singapore on March 26-27, 2007.
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Group and Team Leaders
Profiles
Dr Shu Wang Group Leader Ph.D. in Cell Biology/Neurobiology, Gothenburg University
Dr Francis Eng Hock Tay Group Leader Ph.D. in Mechanical Engineering, Massachusetts Institute of Technology
Dr Yi-Yan Yang Group Leader Ph.D. in Chemical Engineering, Tsinghua University
Dr Hanry Yu Dr Rachel Kraut Group Leader Team Leader and Principal Ph.D. in Cell Biology, Duke University Research Scientist Postdoc, California Institute of Technology Ph.D. in Biology, Columbia University Dr Runsheng Ruan Team Leader and Principal Research Scientist M.D., Z端rich University
Dr Andrew Wan Team Leader and Principal Research Scientist Postdoc, Johns Hopkins University Ph.D. in Chemistry, National University of Singapore
Dr Motoichi Kurisawa Team Leader and Principal Research Scientist Postdoc, Kyoto University Ph.D. in Materials Science, Japan Advanced Institute of Science and Technology
Dr Lang Zhuo Team Leader and Principal Research Scientist Ph.D. in Molecular Biology, University of Wisconsin
Dr Yugen Zhang Team Leader and Principal Research Scientist Postdoc, Harvard University Ph.D. in Analytical Chemistry, University of Science and Technology of China
Dr Namyong Kim Team Leader and Senior Research Scientist Ph.D. in Chemistry, Massachusetts Institute of Technology
Dr Karl Schumacher Team Leader and Senior Research Scientist Habilitation in Anatomy, University of Regensburg M.D., University of Bonn
Dr Hsiao-hua (Bruce) Yu Team Leader and Senior Research Scientist Postdoc, Massachusetts Institute of Technology Ph.D. in Chemistry, Massachusetts Institute of Technology
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Dr Su Seong Lee Team Leader and Principal Research Scientist Postdoc, Massachusetts Institute of Technology Ph.D. in Chemistry, Seoul National University
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Prof Jackie Y. Ying Executive Director Postdoc, Institute for New Materials, Germany Ph.D. in Chemical Engineering, Princeton University
Annual Report 2006
Highlights of the Year
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Fluorescent nanoparticles for bioimaging and cell labeling
Awards
IBN’s Youth Research Program (YRP) attachment students won a total of 6 awards (1 Gold, 1 Silver, 2 Bronze and 2 Merit Awards) at the Singapore Science and Engineering Fair (SSEF) in March 2007. Wu Duo and Vuong Nhat Linh of National Junior College received the Gold Award for their project, “Synthesis of Hyaluronic Acid-Flavonoid Conjugates and Their Biomedical Applications,” under the mentorship of Dr. Motoichi Kurisawa. This year’s SSEF received a total of 247 entries from 423 students nationwide.
In October 2006, Prof. Jackie Y. Ying was appointed by the U.S. National Academy of Engineering to an 18-member blue-ribbon committee tasked to identify the grand challenges for engineering in the next 100 years. The “Grand Challenges for Engineering” initiative launched a website to invite the public to join in a worldwide brainstorming session on ways that engineering can help solve global problems and shape
Research Scientist Dr. Han Yu received the National Science and Technology Young Scientist Award in October 2006 for his work on the synthesis and applications of nanoporous materials. The Young Scientist Award is organized by the Singapore National Academy of Science and supported by A*STAR. Dr. Yiyan Yang’s work on cationic core-shell nanoparticles for the co-delivery of drugs and genes was published in Nature Materials in September 2006. These nanoparticles can carry both small molecular anticancer drugs and nucleic acids simultaneously for improved cancer therapy. The uniqueness of the new technology lies in the design of a special biodegradable carrier in the form of cationic coreshell nanoparticles. The co-delivery of drugs with nucleic acids can improve gene transfection efficiency, reduce the side-effects of these drugs, and achieve the synergistic effect of drug and gene therapy for the more effective treatment of cancer. YRP attachment student Sarah Ong Shu Ren won the Most Outstanding Junior College Science Student Award given out by the Imperial College Alumni Association of Singapore in September
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IBN researchers were given one of the top three prizes in the industry category of the 2006 ASEAN Virtual Instrumentation Applications Contest in December 2006. Their paper, “Making Molecular Diagnosis and Bio-sample Preparation a Breeze through LabVIEW-Inspired System Automation,” was given an honorary mention and is authored by Jeremy Loh, Guolin Xu, James Hsieh, Rosa Qi, Daniel Lee, Chunyan Zhang and Jackie Y. Ying. Molecular diagnosis based on viral DNA or RNA detection is critical for identifying infectious diseases such as avian influenza. The group at IBN has successfully developed a microfluidics-based bio-sample system to process body fluids and blood, as well as to isolate and elute pure DNA or RNA genes for PCR detection. A total of 47 papers from six ASEAN countries were submitted to the contest organized by National Instruments.
our future. In the site’s debut, former U.S. President Jimmy Carter led off an on-line discussion on how engineering efforts can help alleviate human suffering. The top 20 grand challenges in engineering will be selected and announced in September 2007 by the international committee of experts in science and technology. The committee is chaired by former U.S. Defense Secretary William Perry. Other committee members include Lord Alec N. Broers (Chairman of the UK House of Lords Science and Technology Committee), Mr. Larry Page (Founder and first CEO of Google Inc.), Dr. J. Craig Venter (Founder and President of J. Craig Venter Institute), Mr. Dean Kamen (Founder and President of DEKA Research and Development Corp.), Mr. Raymond Kurzweil (Chairman and CEO of Kurzweil Technologies), and Prof. Mario Molina (winner of the Nobel Prize for Chemistry in 1995).
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In FY2006, IBN received recognition both internationally and locally through a series of honors and awards.
2006. As part of her award, she received the opportunity to participate in the Stockholm International Youth Science Seminar in December 2006, where she attended the Nobel Prize Award Ceremonies. The Raffles Junior College student has completed four research attachment stints at IBN, since she first interned at the Institute as a Secondary Three Raffles Girls’ School student in 2003. In August 2006, Prof. Jackie Y. Ying was appointed as a Scientific Advisory Board (SAB) member of Molecular Frontiers. The 24 selected SAB members are top international experts in molecular sciences, and they include 7 Nobel Prize laureates such as Professors Ahmed Zewail, Paul Crutzen, Aaron Klug, Harold Kroto, Jean-Marie Lehn, Ryoji Noyori, and Richard Schrock. The think tank will meet annually to discuss and analyze global scientific developments, as well as to exchange ideas on promoting molecular sciences among the young.
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In June 2006, Prof. Jackie Y. Ying was conferred an Honorary Professorship by Sichuan University President Heping Xie.
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Events, Visits and Seminars The Institute held its First Graduate Student Symposium on June 30, 2006. Organized by IBN’s graduate students, the event showcased the research undertaken by 19 PhD students in oral presentations. IBN introduced its portfolio of technologies to over 60 industrial partners and potential investors at its First Technology Showcase on July 12, 2006. Over 30 research projects were showcased via presentations
and lab demonstrations. In his speech at the event, Guest-of-Honor Executive Chairman of Exploit Technologies Pte Ltd (ETPL) Mr Boon Swan Foo highlighted four IBN projects that had received COT funding. These include IBN’s fully automated biochip for the detection of cancer and infectious diseases such as dengue, SARS or avian influenza, drug-eluting contact lenses for the treatment of a wide array of eye conditions and diseases, collagen-apatite synthetic bone implant for the healing of bone fractures, as well as the Nano-Bio Kits for teachers to demonstrate the applications of biomaterials, medical devices and biofuel cells in school laboratories. IBN organized its Second Annual Research Symposium on August 14-15, 2006. Scientific presentations were given by 65 researchers during the two-day event, which is aimed at facilitating more discussions and collaborations among multidisciplinary teams in the Institute. In conjunction with the Research Symposium, the Institute also held its first retreat at the Focus Adventure Centre at Sentosa on August 16, 2006. IBN staff participated in a series of teambuilding activities to promote greater interaction between different departments and research groups. IBN hosted 55 and 43 visits from companies and institutions respectively in FY2006. Some of these visits were coordinated by A*STAR, the Economic Development Board (EDB) and ETPL. Others were organized as part of IBN’s outreach efforts. Various local and foreign VIPs also visited IBN. This included Mr. Rahul Gandhi, Member of Parliament of India’s National Congress Party and son of Mrs. Sonia Gandhi, and Minister of State (Ministry of Trade and Industry) Mr. S. Iswaran.
IBN hosted 43 distinguished speakers in its Seminar Series in FY2006.
2. Prof Matt Trau University of Queensland, Australia Drug and Gene Nano-Balls: Applications in Genomics, Proteomics, Diagnostics and Personalised Medicine April 4, 2006 3. Prof Andreas Manz Institute for Analytical Sciences, Germany Chip Technology, Nanoliters and Picoliters – Miniaturization of (Bio)analytical Chemistry Methods April 11, 2006
5. Prof Ekkehardt Hahn Westfälische Wilhelms-Universität Münster, Germany Cyclic Polycarbene Ligands by a Template Controlled Domino Reaction and Application of their Complexes in Catalysis April 21, 2006 6. Prof James R. Heath California Institute of Technology, USA NanoSystems Biology and New Technologies for In Vitro and In Vivo Diagnostics of Cancer June 14, 2006
Prof James R. Heath California Institute of Technology, USA Short Courses on Systems Biology and Human Diseases; State-of-the-Art Genomics and Proteomics; In Vitro Diagnostics and Label-Free Detectors; Microfluidics and Non-Microfluidics Environments; Technology Bottlenecks and Protein Capture Agents; and Molecular Imaging and In Vivo Diagnostics June 14-16, 2006
8. Prof Younan Xia University of Washington, USA Shape-Controlled Synthesis of Nanostructures: Simple Chemistry Meets Complex Physics June 15, 2006 9. Dr Andrey Zarur BioProcessors Corp., USA BioProcessors’ High Throughput Cell Culture Platform June 19, 2006 10. Dr Robin H. Liu CombiMatrix Corp., USA Integrated Microfluidic and ElectraSense Microarray Biochips June 27, 2006 11. Prof Kinam Park Purdue University, USA Drug Delivery: Evolution into the Nanotechnology Era July 3, 2006 12. Prof Peter T. C. So Massachusetts Institute of Technology, USA New Tools for High Throughput, High Content Microscopic Imaging July 20, 2006 13. Prof Paula Hammond Massachusetts Institute of Technology, USA Nanoscale Approaches to Biomaterials – from Thin Film Assemblies to Solution Assembly July 27, 2006
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4. Prof Zhongfan Liu Peking University, China Single-Walled Carbon Nanotubes - From Chemical Assembly, Controlled Surface Growth to Axial Bandgap Engineering April 19, 2006
7.
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1. Dr Pearl Chin Seraphima Ventures, USA How to Develop and Implement an Excellent Marketing Strategy April 3, 2006
14. Prof Krijn de Jong Utrecht University, The Netherlands Studies on the Preparation of Nanostructured Catalysts Using Electron Tomography July 31, 2006
22. Prof Kim D. Janda The Scripps Research Institute, USA Interfacing Chemistry with Biology for the 21st Century October 26, 2006
15. Prof Joel Voldman Massachusetts Institute of Technology, USA Microsystems for Manipulating and Measuring Cells August 1, 2006
23. Prof Kazuhiko Ishihara University of Tokyo, Japan Nanobiointerfaces With Bioinspired Polymer Materials October 30, 2006
16. Prof Jianzhu Chen Massachusetts Institute of Technology, USA RNA Interference of Influenza Virus Infection August 2, 2006
24. Prof Frank Caruso University of Melbourne, Australia Bridging the Materials and Life Science Divide: Bioinspired Colloidal Systems October 31, 2006
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17. Prof Buddy D. Ratner University of Washington, USA Evolving Biomaterials: A 60-Year Journey from Off-the-Shelf to Bioengineered August 3, 2006
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18. Prof Gerald G. Fuller Stanford University, USA Complex Fluid Interfaces August 7, 2006 19. Dr Morten Foss University of Aarhus, Denmark Proteins And Cells On Topographically Structured Tantalum August 8, 2006 20. Prof Wolfgang F. Hoelderich University of Technology, RWTH Aachen, Germany The Use of Heterogeneous Catalysts in the Synthesis of Pharmaceuticals August 10, 2006 21. Prof Wolfgang A. Herrmann Technische Universit채t M체nchen, Germany New Strategies in Organometallic Catalysis August 31, 2006
25. Prof Viola Vogel ETH Z체rich, Switzerland Harnessing Biological Motors and Nanoswitches for Technical Applications November 3, 2006 26. Prof Dieter Falkenhagen Danube University, Austria New Technologies for Extracorporeal Blood Purification using Nano- and Micro-Particles in Suspension and Their Potential Applications in Acute Liver Failure and Sepsis November 6, 2006 27. Prof Michael P. Sheetz Columbia University, USA Understanding Cellular Mechanics through Nanotechnology November 15, 2006 28. Prof Paul Mulvaney University of Melbourne, Australia Single Nanocrystal Spectroscopy November 24, 2006 29. Prof Chung-Yuan Mou National Taiwan University, Taiwan Biomedical Applications of Mesoporous Silica December 6, 2006
32. Prof Tae Gwan Park Korea Advanced Institute of Science and Technology, Korea Smart Nanobiomaterials for Drug, Gene and Cell Therapy December 15, 2006
39. Dr Daniele Zink University of Munich, Germany Gene Regulation and Genome Reprogramming: Bioimaging Meets Epigenetics and Systems Biology January 5, 2007
33. Prof Jennifer Elisseeff Johns Hopkins University, USA Tissue Engineering in the Musculoskeletal System December 18, 2006
40. Prof Keith E. Gubbins North Carolina State University, USA Phase Change and Chemical Reactions at the Nanoscale: Effects of Confinement January 25, 2007
34. Dr Robert D. Shull National Institute of Standards and Technology, USA Nanobiotechnology: Nanotechnology Applied to Biology December 19, 2006
41. Prof Stephen Buchwald Massachusetts Institute of Technology, USA Transition Metal-Catalyzed Carbon-Carbon and Carbon-Heteroatom Bond-Forming Processes: Progress, Applications and Mechanistic Studies January 26, 2007
35. Prof Dongyuan Zhao Fudan University, China Synthesis and Structures of Highly Ordered Mesoporous Polymers and Carbon Frameworks December 20, 2006
42. Prof Teruo Okano Tokyo Women’s Medical University, Japan Cell Sheet Tissue Engineering January 30, 2007
36. Prof Dan Luo Cornell University, USA Nucleic Acid Engineering: Molecular Engineering DNA as a Generic Instead of Genetic Material December 20, 2006 37. Prof Sunney I. Chan California Institute of Technology, USA Molecular Basis of Protein Aggregation Diseases December 21, 2006
43. Prof William Bonfield University of Cambridge, UK From Concept to Patient - Biomaterials Solutions to Tissue Regeneration February 9, 2007 44. Prof Allan Hoffman University of Washington, USA Short Courses on Biomaterials and Drug Delivery Systems February 12-14, 2007
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31. Prof Hsian-Rong Tseng University of California, Los Angeles, USA Miniaturized Chemistry and Biology Laboratory in a Microfluidic Chip December 14, 2006
38. Prof Bengt Norden Chalmers University of Technology, Sweden Polarized-Light Spectroscopy on Nucleic Acid and Membrane Systems - Recognizing Some Novel Interaction Concepts Peer Reviewing and Recognizing Great Ideas – A Vision Through the Nobel Prizes A New Science and Outreach Program: Molecular Frontiers January 4, 2007
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30. Prof I-Wei Chen University of Pennsylvania, USA A Perspective of Nanoceramics December 13, 2006
Conference Organization
Jackie Y. Ying International Advisory Board, 11th CIMTEC International Ceramics Congress and Forum on New Materials, Sicily, Italy (June 4-9, 2006)
National Advisory Committee, 4th International Conference on Materials for Advanced Technologies, Singapore, International Scientific Committee for the Symposium on New Routes to Inorganic Materials, Films and Nanocrystals (July 1-6, 2007)
International Scientific Committee, 2nd Asia Pacific Nanotech Forum International Symposium on Nanotechnology in Environmental Protection and Pollution, Hong Kong (June 18-21, 2006)
International Advisory Board, International Joint Conference on Knowledge Management for Composite Materials, Nanotechnology and Fuel Cell, D端sseldorf, Germany (July 3-6, 2007)
International Advisory Board, 5th International Mesostructured Materials Symposium, Shanghai, China (August 5-7, 2006)
Conference Chair, 3rd Society for Biological Engineering International Conference on Bioengineering and Nanotechnology, Singapore (August 12-15, 2007)
Annual Report 2006
Organizing Committee, 2nd Society for Biological Engineering International Conference on Bioengineering and Nanotechnology, Santa Barbara, California (September 5-7, 2006)
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International Advisory Board, 4th Asia Pacific Congress on Catalysis, Singapore (December 6-8, 2006) International Advisory Board, International Conference in Biomedical and Pharmaceutical Engineering, Singapore (December 11-13, 2006) Steering Committee, Global Enterprise for MicroMechanics and Molecular Medicine Conference on Cancer, Singapore (July 1-6, 2007)
International Organizing Committee, 1st International Conference on Cellular and Molecular Engineering, Singapore (December 10-12, 2007) International Advisory Committee, 5th Singapore International Chemistry Conference, Singapore (December 16-19, 2007) Scientific Program Committee, Asia Pacific Symposium on NanoBionics, Wollongong, Australia (June 8-11, 2008) International Advisory Board, 6th International Mesostructured Materials Symposium, Belgium (September 7-11, 2008)
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International Advisory Board, International Conference of Transducer, Beijing, China (June 1, 2011)
Yi-Yan Yang
Scientific Committee, iMEMS 2006, Singapore (May 9-12, 2006)
Organizing Committee, 9th International Symposium by Chinese Organic Chemists and 6th International Symposium by Chinese Inorganic Chemists, Singapore (December 18-20, 2006)
Program Committee, Smart Materials, Nano- and Micro-Smart Systems 2006, Adelaide, Australia (December 10-13, 2006) Session Chair of Smart Materials, Nano- and MicroSmart Systems 2006, Adelaide, Australia (December 10-13, 2006)
Chair, 4th International Conference on Materials for Advanced Technologies (ICMAT 2007) Symposium on Advanced Functional Biomaterials, Singapore (July 1-6, 2007)
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Ciprian Iliescu
Francis Tay Technical Program Committee, IEEE International Sensors Conference, Atlanta, Georgia, USA (October 28-31, 2007)
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Annual Report 2006
Highlights of the Year
Media Coverage
IBN received local and international media coverage in FY2006 on its achievements, research activities and youth outreach programs.
Annual Report 2006
Print Media
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Date
Article
Media Source
26 Mar 2007
Budding scientists at the Biopolis
The Straits Times (IN)
15 Mar 2007
IBN’s mini lab-on-a-chip revolutionizes disease detection
PharmaAsia
12 Mar 2007
IBN Nano-Bio Kits demonstrate bioengineering and nanotechnology through interactive experiments
Gizmag
12 Mar 2007
Singapore is arming teachers with educational nanotechnology kits
Nanotechnology News
12 Mar 2007
Singapore exports nanotechnology learning tools
Nanodot
12 Mar 2007
Nano kit to add zing to classrooms
BioSpectrum
10 Mar 2007
Students learn about nanotechnology through interactive experiments
Lianhe Zaobao
10 Mar 2007
Students get taste of nanotechnology
The Straits Times
09 Mar 2007
Nanobiotechnology educational kit launched to help students, teachers
Channel NewsAsia
01 Jan 2007
Contact lenses to treat eye diseases
Innovation Magazine
30 Dec 2006
Local R&D efforts that made their mark
The Straits Times
22 Dec 2006
From 0 to 60 in 6 years
Engineering Weekly (Aret Rundt)
16 Dec 2006
Pushing back frontiers of stem cell research
The Straits Times
29 Nov 2006
The difference in decision-making
Mainichi Newspaper
Article
Media Source
04 Nov 2006
The inventor
The Straits Times
01 Nov 2006
Nanoparticles deliver the goods
NanoToday
14 Oct 2006
Local team uses nanoparticles to treat cancer
The Straits Times
12 Oct 2006
S’pore honors scientists for cutting-edge work
The Business Times
12 Oct 2006
Investment in R&D hit $4.58 billion last year
The Straits Times
01 Oct 2006
Nanotechnology
Nature Nanotechnology
28 Sep 2006
Local research institute’s new nanocarriers can potentially kill cancer cells
Lianhe Zaobao
25 Sep 2006
Gene therapy synchronization studied
UPI.com
01 Sep 2006
Artificial fibres imitate nature’s scaffolding
Innovation Magazine
03 Aug 2006
Hydrogen quick and clean
Nature News & Views
14 Jul 2006
A*STAR - For your eyes only
Today
06 Jul 2006
Quick PCR microchip
Chemical Biology
01 Jul 2006
Scaffolds to grow new tissue
Biome
30 Jun 2006
IBN creates scaffold for growing cells and tissues
Biomed Singapore
02 Jun 2006
S’pore luring the West’s best biotech brains
The Straits Times
01 Apr 2006
Safer disease treatments through IBN’s hydrogel
Biomed Singapore
Date
Program
Media Source
17 Mar 2007
Young Expressions: Sarah Ong
Radio Singapore International
01 Mar 2007
Detik – First Class City
Suria
20 Nov 2006
Passion People: Feature on IBN’s research in cell and tissue engineering
NewsRadio 93.8
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Broadcast Media
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Date
Annual Report 2006
Gold electrodes for electrochemical detection of pathogens, viruses and cancer genes
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IBN conducts research at the interface of bioengineering and nanotechnology to produce novel technology platforms that would make a significant impact both scientifically and commercially.
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Intellectual Capital
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Core Research and Technology Areas
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Enzyme-mediated injectable hydrogel for drug delivery and tissue engineering
IBN is currently working on 64 exciting research projects in six research areas. By combining the knowledge and tools available in each of these areas, IBN has established new frontiers in science, engineering and medicine.
By establishing and targeting the latest scientific and engineering approaches for biomedical technologies, IBN has carved a niche in the development of knowledge, intellectual property and talent. In particular, the Institute has converged multiple disciplines to build six areas of research: Delivery of Drugs, Proteins and Genes, where the controlled release of various therapeutics involves the use of nanoparticles with functionalized moieties for targeting diseased cells and organs, or for responding to specific biological stimuli. Cell and Tissue Engineering, where sophisticated materials architecture is employed to design and fabricate living replacement devices for surgical reconstruction and transplantation. Artificial Organs and Implants, where multi-functional systems and devices are engineered as biomimetic structures for use as organ replacement.
Medical and Biological Devices, which involve nanotechnology and microfabricated systems for facilitating life sciences research, drug discovery, as well as the detection and treatment of diseases. Bioimaging and Biosensing, which comprises the imaging of cells, tissues, small animals and biomaterials using advanced techniques and novel imaging tags, as well as the sensing and detection of biologics and biomolecules using nanostructured materials.
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Pharmaceuticals Synthesis and Nanobiotechnology, which encompasses the efficient catalytic synthesis and separation of chiral pharmaceuticals and specialty chemicals.
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Research Projects
Delivery of Drugs, Proteins and Genes – Anti-Ageing and Age-Related Diseases – Biocompatible Polycation-based Gene Delivery Vectors – Biodegradable Cationic Core-Shell Nanoparticles for Co-delivery of Drugs and Genes – Chimeric Peptides for Receptor-Mediated Gene Transfer – Chitosan-based Non-Viral Gene Carriers – Engineered Gene Expression Promoters – Hair Cell Regeneration – Injectable Biodegradable Hydrogels for Drug Delivery and Tissue Engineering – Nanostructured Drug-Loaded Contact Lenses for Ocular Drug Delivery
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– Nanostructured Temperature-Sensitive Membranes for Wound Healing and Cell Grafting
Cell and Tissue Engineering – Bio-Inspired Responsive Polymers in Drug Delivery and Tissue Engineering – Cell Therapies for Renal Failure – Custom-Designed Biomaterials, Devices and Processes to Support Liver Cell Functions and Expansion in Three-Dimensional Cultures – Engineering of Microliver Tissues – Fibrous Scaffolds for Tissue Engineering – Gene Transfer Systems for Versatile Genetic Modification of Stem Cells – Growth Factor Gene Delivery and Nerve Regeneration – Human-on-Chip Physiology-based Pharmacokinetics Model for Drug Screening – Influence of Extracellular Microenvironments on Liver Cell Dynamics and Functions – Metabolomic Profiling of Cellular Differentiation
– Nasopharyngeal Carcinoma and Cancer Stem Cells
– Renewable Bio-Artificial Liver-Assisted Device
– Recombinant Baculovirus Vectors: Applications in Brain Gene Therapy
– Role of Cathepsins in Hepatic Stellate Cells
– Small Interfering RNAs for Gene Therapy of Brain Tumors – Stimuli-Sensitive Core-Shell Nanoparticles for Cancer Therapy – Synthesis of Versatile Micellar Nanocomplexes for Drug Delivery – Targeted Gene and Drug Delivery
– Stellate Cell Engineering
Artificial Organs and Implants – Cell and Organ Printing of Tubular Structures – Collagen-Apatite Nanofoams as Bone Implants for Load-Bearing Applications – Development of New Types of Bioartificial Renal Tubule Assist Devices
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– Three-Dimensional Bone Remodeling of Nanobiomaterials
– Catalytic and Biological Applications of Magnetic Nanoparticles – Conducting Polymer-based Biosensor – Development of Chiral Catalysts Using HighThroughput Synthesis and Reaction Optimization – Development of New Heterogeneous Catalysts for the Asymmetric Synthesis of Pharmaceuticals – Engineering Robust and Photostable Luminescent ZnO Films
– Microfluidic Devices for Studying Cell Migration and Deformation – Microneedle Array for Transdermal Drug Delivery – Miniaturized Microtiter Plate – Platform Technologies and Microdevices for Artificial Organs – Sensors and Actuators for Minimally Invasive Devices – Three-Dimensional Cell Culture Using Two-Photon Stereolithography – Virtual Reaction Chamber
– Immobilization of Homogeneous Catalysts and Biocatalysts on Nanoporous Materials – Luminescence Detection by Switching Photostability of Nanocrystals – Organocatalytic Synthesis of Chiral Pharmaceuticals – Ultrasensitive Nucleic Acid Biosensors for an Early Cancer Diagnosis
Medical and Biological Devices
Bioimaging and Biosensing – A Sphingolipid Binding Peptide as a Targeting Mechanism for Quantum Dot Probes – Bioimaging and Biosensing for Liver Tissue Engineering – Development of Novel Peptide and Lipid Markers to Trace Sphingolipid Trafficking in Living Cells – Imaging Fluorescent-Labeled Lipid Analogs in Drosophila Cultured Neuronal Cell Lines
– Automatic Gene Synthesizer
– Imaging Subcellular Events in a Drosophila Model of Neuronal Degeneration
– Dielectrophoresis Cell-Bead Binding for Gene Extraction
– Imaging Vesicular Trafficking in a Drosophila Model of Neuronal Degeneration
– Flexible Cell Microarray
– In Vivo Biological Imaging
– Giant Liposomes as Microreactors
– Semiconductor and Magnetic Quantum Dots for Biolabeling, Bioimaging and Bioseparation
– High-Performance Multimode Scanning Probe Microscopy – High-Throughput Oligonucleotide Synthesizer
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Annual Report 2006
– A Fully Integrated Biochip for Early Cancer Diagnosis
Institute of Bioengineering and Nanotechnology
Pharmaceuticals Synthesis and Nanobiotechnology
Research Highlights
Delivery of Drugs, Proteins and Genes
Annual Report 2006
In this area of research, IBN scientists are designing innovative materials that allow greater precision and control in drug delivery to improve therapeutic efficiency and minimize side-effects. In FY2006, IBN’s drug delivery group designed a pH- and temperature-sensitive copolymer, which can form core-shell nanoparticles with narrow size distribution, excellent thermosensitivity and folate on its surface for targeted delivery of anticancer drugs. The group also synthesized cationic polymer nanoparticles for the simultaneous delivery of gene (IL-12 encoded plasmid) and drug (paclitaxel), achieving a synergistic effect in suppressing the growth of mouse breast tumors. This significant piece of research was published in Nature Materials. These nanoparticles were found to be promising carriers for protein delivery, and displayed antimicrobial properties. Functional micelles for the delivery of antibiotics were also developed to cross the blood-brain barrier. In its wound-healing/cell grafting research, the group carried out further work on its nanostructured membranes with cell attachment and thermosensitive swelling properties by conjugating RGD peptide onto the thermosensitive membranes to improve cell attachment.
Institute of Bioengineering and Nanotechnology
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IBN scientists are also designing biocompatible, biodegradable and injectable hydrogels for the localized delivery of therapeutic agents and cells. In FY2006, they developed a very simple gel-forming system composed of biodegradable polymer-flavonoid conjugates using a peroxidase-catalysed oxidation reaction for oscillatory drug release. In addition, the group successfully formed hydrogels composed of HA-(-)-epigallocatechin gallate (HA-EGCG) conjugates and conducted biodegradability and protein release studies. This system will provide great advantages in highly regulated drug delivery through the controlled release of bioactive molecules. Hydrogels composed of gelatin-phenol conjugates were also synthesized for controlling stem cell differentiation and cell functions in tissue repair/regeneration applications.
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IBN’s gene delivery group has been working towards developing gene delivery systems for applications in brain cancer gene therapy. In FY2006, the group established a novel technology to use safe insect viruses to cure human brain tumors in an animal model. This technology circumvents some of the inherent problems associated with current technologies and opens up new opportunities for cancer gene therapy. Using the same virus, the group developed a new method to introduce foreign genes effectively into human embryonic stem cells. This enabling method offers great potential in the genetic engineering of human embryonic stem cells for regenerative medicine. Epstein-Barr virus (EBV) is a human-specific virus associated with the development of various cancers. The pathogenesis of these malignancies remains unclear largely because there is no animal model currently that can adequately recapitulate EBV infection in humans. With the successful reconstitution with human B and T cells in NOD-scid IL2Rγ null mice, IBN scientists have developed a mouse model of latent EBV. Susceptibility to natural EBV infection of this system is useful for studies on pathogenesis, prevention and treatment of EBV infection, and its association with carcinogenesis.
Cell and Tissue Engineering IBN researchers have shown that hepatic stellate cells (HSCs) found in the liver expressed all key molecules required to present antigens. This finding paved the way to establish the HSCs as antigen-presenting cells (APCs) in the liver, and this may have implications in hepatic auto-immuno disorders and liver transplants. The group also established a proof-of-concept in using a genetically engineered HSC cell line for screening pro- and anti-fibrotic agents in a high-throughput fashion. In addition, the group made significant progress in targeting stellate cells in the pancreas using a cell-specific promoter. This discovery lays the groundwork for the targeted delivery of gene and/or drug to combat fibrosis in the pancreas.
Institute of Bioengineering and Nanotechnology
IBN expanded its portfolio of biomaterials to fibrous scaffolds, membranes and hydrogels, specifically for 3D cell culture and tissue engineering applications. A 3-tiered membrane system was designed, where biological functionality is presented on a nonfouling surface. A swellable form of membrane was successfully used for pellet culture with human mesenchymal stem cells (hMSCs). Cell-responsive particles were also designed with heparin conjugation to increase the proliferation of hMSCs in pellet culture.
Artificial Organs and Implants Enabling technologies for engineering and monitoring of extracellular microenvironments in liver tissue engineering constructs are being developed in this area. In FY2006, IBN researchers showed that the coupling of biliary excretion with improved waste removal can be important for the long-term maintenance of liver cells (hepatocytes). In addition, the group developed a synthetic, collagen-free bioactive substratum, which promotes cell adhesion and functions synergistically. The design of a polymeric intercellular linker, PEI-hydrazide, could also be used to promote cell culture in three dimensions (3D). IBN is creating innovative bioreactors that are able to maintain cell functions of both liver cells and tissue slice constructs over an extended period. In particular, it developed a microfluidic system for 3D culture of mammalian cells such as HepG2 and MCF7, bone marrow stem cells and primary rat hepatocytes. Two perfusion systems were successfully created, i.e. a novel rotating perfusion bioreactor for sandwich cell culture and an intratissue perfusion system for the culture of thick liver slices.
Annual Report 2006
Severe donor shortages have led to a growing need for viable substitutes or regenerative approaches for diseased or malfunctioning organs or tissues. Kidney disease is one of the most prevalent medical conditions worldwide, and IBN scientists have been working on creating effective renal assistive devices and replacements. They have developed a flat-bed bioreactor system based on novel polymer membranes
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Microfluidic channels with micropillar array for 3D mammalian cell culture
to help patients suffering from renal failure. This system is a multi-compartment bioreactor combining the filtration and reabsorption functions of the kidney, unlike conventional dialysis systems that only have filtration capability. The team also fabricated hollow fiber systems using IBN’s biodegradable hydrogels and tubular systems consisting of kidney cells.
Pharmaceuticals Synthesis and Nanobiotechnology
Annual Report 2006
The pharmaceuticals synthesis research at IBN is focused on improving the efficiency of catalytic synthesis and separation of chiral drugs, which constitute over one-third of all pharmaceuticals currently sold worldwide. Novel protocols for the highly efficient synthesis of β-aminoacid and hydroxamic acid were developed with N-heterocyclic carbene organic catalysis. IBN researchers have also immobilized ring-closing metathesis catalysts on mesocellular siliceous foams (MCF) through precapping and carbamate linker groups. These heterogeneous catalysts achieved excellent activity for a wide range of substrates. The ease of recyclability of these novel catalysts would be very useful in pharmaceuticals manufacturing processes to derive macrocyclic drugs.
Institute of Bioengineering and Nanotechnology
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Medical and Biological Devices Through the use of microfabrication, microfluidics and nanotechnology, scientists at IBN are designing novel medical and biological devices for gene synthesis, drug screening and disease diagnostics. In FY2006, the medical devices group developed a novel cell separation technique in a 3D dielectrophoretic chip and generated a new method for determining virus concentration using impedance spectroscopy. It has also further developed its lab-on-chip systems for integrated gene extraction, purification and analysis of biosamples using disposable biochips and desktop systems as well as virtual reaction chambers. These devices are very useful in the detection of diseases such as cancer and avian flu.
In the area of biological devices, IBN is developing miniaturized microfluidic platforms for biological assays. The scientists successfully developed prototype systems, called DropArrays, which enable the miniaturization of rinsing bioassays by 50-1000 times, with improved efficiencies of up to 10 times. Rinsing bioassays include protein immunoassays such as enzyme-linked immunosorbent assay (ELISA) and cell-based assays. The platform is expected to benefit the life sciences and drug discovery communities, accelerating their research progress by greatly reducing the cost and time required to conduct bioassays. Such a reduction is useful in primary cell and stem cell research, where the cells are often expensive and/or limited. IBN also developed and tested a new technique of transdermal drug delivery using ultrasonic enhanced microneedle array. It established a platform technology involving the low stress and high deposition rate of SiNX layers with applications in cell culture.
Bioimaging and Biosensing The molecular and microscopic imaging of medical systems, biomaterials, biologics, tissues and cells is critical in both in vitro and in vivo studies. In FY2006, IBN researchers established a technical platform for non-invasive imaging and quantifying of transcriptional expression of a biomarker (GFAP) in the brain of conscious transgenic neonatal mice for profiling developmental neurotoxicity. They also obtained the proof-of-concept for the non-invasive imaging of GFAP biomarker expression in the transgenic retina at cellular resolution. These technical breakthroughs will open up opportunities for studying and developing therapies for various neural disorders, ranging from Parkinson’s and Alzheimer’s diseases and stroke to diabetes and hepatic retinopathies. IBN scientists also conducted an imaging-based and biochemical analysis of a novel lipid-binding peptide probe, the SBD, and analyzed its association with
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Annual Report 2006
In addition, IBN researchers successfully developed methods to create biocompatible silica-coated magnetic quantum dots. Such nanocomposite material would enable simultaneous biolabeling/ imaging and cell sorting/separation. Previous methods to obtain these composites suffer from a low photoluminescence quantum yield and little control over the linking of quantum dots and magnetic particles with suitable ligands. IBN scientists, however, have tackled these problems and have also shown a simple bio-conjugation method for the labeling of different live cell membranes to allow biologists to understand the mechanisms used by cells to allow DNA and ions to directly traverse biological membranes. IBN scientists also developed glutathione-capped cadmium telluride (CdTe) quantum dots using a cost-efficient and convenient synthesis method. With a multilayer coating, the final size of commercially available quantum dots would be typically 12–20 nm, which might be too bulky for them to gain access into cells for in vitro and in vivo imaging. In contrast, the overall size of IBN’s quantum dots are as small as 4 nm, which allows for deeper penetration into fine cellular targets such as the nucleolus. These new materials exhibit fluorescence efficiency as high as ~45%, and are biocompatible, monodispersed and stable under the physiological conditions.
Polyethylenedioxythiophene (PEDOT) has demonstrated itself as the most promising material among conducting polymers, and IBN researchers are exploring the potential of PEDOT and its derivatives in biosensor applications. In FY2006, they developed microemulsion-based electropolymerization and chemical polymerization of functionalized PEDOT films. These biocompatible thin films served as nanobiointerfaces for biocircuits, and were capable of nucleic acid and protein detection. EDOT intercalators were also synthesized and examined as an amplified reporter. For label-free PEDOT sensors, IBN scientists also found a novel conductimetric response from shifting the conductivity curve of functionalized PEDOTs, enabling them to be applied in label-free biomolecular detection.
Institute of Bioengineering and Nanotechnology
lipid domains in Drosophila and human neuronal cells. They established that lipid domains existed in their neuronal cell lines and behaved similarly to mammalian cells, with respect to lipid composition, association with known raft markers, and SBD binding. They also characterized the behavior of fluorescent sphingolipid analogs in Drosophila neurons. FL-sphingolipids were incorporated by cultured neuronal cells and underwent intracellular trafficking, followed quantitatively by time-lapse confocal and widefield microscopy. Lipid analogs, as well as SBD, underwent changes in intracellular trafficking under lipid perturbations in fly cells. This provided the basis for the use of Drosophila to study and screen lipid trafficking in models of neurodegenerative diseases.
Drosophila neurons labeled by novel peptides
Annual Report 2006
Publications and Presentations
Institute of Bioengineering and Nanotechnology
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In FY2006, IBN published 17 conference proceedings and 84 papers in archival journals, 33 of which had impact factors of 3 and above. In addition, IBN scientists were invited to give keynote lectures at 56 scientific conferences.
Dielectrophoresis cell manipulation chip for cell isolation
Journal Publications
5. B. H. Liu, Y. Yang, J. F. R. Paton, F. Li, J. Boulaire, S. Kasparov and S. Wang GAL4-NFĸ β Fusion Protein Augments Transgene Expression from Neuronal Promoters in the Rat Brain Molecular Therapy, 14 (2006) 872-882. 6.
7. 1. Y. Wang, S. J. Gao, H. Wen, H. S. Yoon and Y. Y. Yang Co-delivery of Drugs and DNA from Cationic Core–Shell Nanoparticles Self-Assembled from a Biodegradable Copolymer Nature Materials, 5 (2006) 791-796.
3.
4.
L. S. Wang, P. Y. Chow, T.-T. Phan, I. J. Lim and Y.Y. Yang Fabrication and Characterization of Nanostructured and Thermo-sensitive Membranes for Wound Healing and Cell Grafting Advanced Functional Materials, 16 (2006) 11711178. K. S. Soppimath, L. H. Liu, W. Y. Seow, S. Q. Liu, R. Powell, P. Chan and Y. Y. Yang Multi-Functional Polymer Core-Shell Nanoparticles Self-Assembled from pHInduced Thermally Responsive Polymer for Targeted Anticancer Drug Delivery Advanced Functional Materials, 17 (2007) 355362.
8.
9.
S. Q. Liu, N. Wiradharmaa, S. J. Gao, Y. W. Tong and Y. Y. Yang Bio-functional Micelles Self-Assembled from a Folate-Conjugated Block Copolymer for Targeted Intracellular Delivery of Anticancer Drugs Biomaterials, 28 (2007) 1423-1433. W. Y. Seow, J. M. Xue and Y. Y. Yang Targeted and Intracellular Delivery of Paclitaxel Using Multi-functional Polymeric Micelles Biomaterials, 28 (2007) 1730-1740. J. Zeng, X. Wang and S. Wang Self-Assembled Ternary Complexes of Plasmid DNA, Low Molecular Weight Polyethylenimine and Targeting Peptide for Nonviral Gene Delivery into Neurons Biomaterials, 28 (2007) 1443-1451.
10. C. Y. Wang and S. Wang Astrocytic Expression of Transgene in the Rat Brain Mediated by Baculovirus Vectors Containing an Astrocyte-Specific Promoter Gene Therapy, 13 (2006) 1447-1456. 11. G. P. Tang, H. Y. Guo, F. Alexis, X. Wang, S. Zeng, T. M. Lim, J. Ding, Y. Y. Yang and S. Wang Low Molecular Weight Polyethylenimines Linked by β-Cyclodextrin for Gene Transfer into the Nervous System Journal of Gene Medicine, 8 (2006) 736-44.
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Annual Report 2006
2. F. Alexis, S. L. Lo and S. Wang Covalent Attachment of Low Molecular Weight Polyethylenimine Improves Tat Peptide-Mediated Gene Delivery Advanced Materials, 18 (2006) 2174-2178.
P. Chan, M. Kurisawa, J. E. Chung and Y. Y. Yang Synthesis and Characterization of Chitosang-Poly(ethylene glycol)-Folate as a Non Viral Carrier for Tumor-Targeted Gene Delivery Biomaterials, 28 (2007) 540-549.
Institute of Bioengineering and Nanotechnology
Delivery of Drugs, Genes and Proteins
12. Y. Wang, L. S. Wang, S. H. Goh and Y. Y. Yang Synthesis and Characterization of Cationic Micelles Self-Assembled from A Biodegradable Copolymer for Gene Delivery Biomacromolecules, 8 (2007) 1028-1037.
18. D. Tan, B. Zhao, S. Moochhala and Y. Y. Yang Pharmacokinetic Profile of a SustainedDelivery System for Physostigmine in Rats Materials Science and Engineering B, 132 (2006) 155-158.
13. X. Jiang, H. Dai, K. W. Leong, S. H. Goh, H. Q. Mao and Y. Y. Yang Chitosan-g-PEG/DNA Complexes Deliver Gene to the Rat Liver via Intrabiliary and Intraportal Infusions Journal of Gene Medicine, 8 (2006) 477-487.
19. T. B. Bini, S. J.Gao, S. Wang and S. Ramakrishna Poly(l-lactide-co-glycolide) Biodegradable Microfibers and Electrospun Nanofibers for Nerve Tissue Engineering: An In Vitro Study Journal of Materials Science, 41 (2006) 64536459.
14. Y. T. Wong, R. S Ruan and F. E. H. Tay Relationship between Levels of Oxidative DNA Damage, Lipid Peroxidation and Mitochondrial Membrane Potential in Young and Old F344 Rats Free Radical Research, 40 (2006) 393-402.
Annual Report 2006
15. Y. Y. Yang, Y. Wang, R. Powell and P. Chan Polymeric Core-Shell Nanoparticles for Therapeutics Clinical & Experimental Pharmacology and Physiology, 33 (2006) 557-562.
Institute of Bioengineering and Nanotechnology
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16. C. Y. Wang, F. Li, Y. Yang, H. Y. Guo, C. X. Wu and S. Wang Recombinant Baculovirus Containing the Diphtheria Toxin A Gene for Malignant Glioma Therapy Cancer Research, 66 (2006) 1-9. 17. D. Tan, B. Zhao, S. Moochhala and Y. Y. Yang Sustained-Release of Caffeine from a Polymeric Tablet Matrix: An In Vitro and Pharmacokinetic Study Materials Science and Engineering B, 132 (2006) 143-146.
20. H. W. Yu, H. Chen, X. Wang, Y. Y. Yang and C. B. Ching Cross-Linked Enzyme Aggregates (CLEAs) with Controlled Particles: Application to Candida Rugosa Lipase Journal of Molecular Catalysis B-Enzymatic, 43 (2006) 124-127. 21. Q. Y. Meng, Y. Wong, J. Chen and R. Ruan Age-related Changes in Mitochondrial Function and Antioxidative Enzyme Activity in Fischer 344 Rats Mechanisms of Ageing and Developments, 128 (2007) 286-292. 22. Z. Shang, D. N. Ting, Y. T. Wong, Y. C. Tan, B. Ying and Y. Mo A Study of DFT and Surface Enhanced Raman Scattering in Silver Colloids for Thymine Journal of Molecular Structure, 826 (2007) 64-67.
27. X. T. Pan, Y. C. Toh, H. Yu and T. Wohland Characterization of Poly(acrylic acid) Diffusion Dynamics on the Grafted Surface of Poly(ethylene Terephthalate) Films by Fluorescence Correlation Spectroscopy Biophysical Review and Letters, 1 (2006) 1-9. 28. C. Y. Zhang and L. Zhuo EGCG and Genistein Attenuate GFAP Elevation Induced by Fibrogenic Cytokines in Hepatic Stellate Cells International Journal of Molecular Medicine, 18 (2006) 1141-1151.
23. G. Maubach, M. C. C. Lim, S. Kumar and L. Zhuo Expression and Upregulation of Cathepsin S and Other Early Molecules Required for Antigen Presentation in Activated Hepatic Stellate Cells upon IFN-Îł Treatment Biochimica et Biophysica Acta - Molecular Cell Research, 1773 (2007) 219-231.
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Annual Report 2006
24. L. L. Ong, P. C. Lin, X. Zhang, S. M. Chia and H. Yu Kinectin-Dependent Assembly of Translation Elongation Factor-1 Complex on Endoplasmic Reticulum Regulates Protein Synthesis Journal of Biological Chemistry, 281 (2006) 33621-33634. 25. E. K. F. Yim, A. C. A. Wan, C. Le Visage, I. C. Liao and K. W. Leong Proliferation and Differentiation of Human Mesenchymal Stem Cell in Polyelectrolyte Complexation Fibrous Scaffold Biomaterials, 27(2006) 6111-6122. 26. S. C. Wong, H. Yu and J. B. So Detection of Telomerase Activity in Gastric Lavage Fluid: A Novel Method to Detect Gastric Cancer Journal of Surgical Research, 131 (2006) 252-255.
Institute of Bioengineering and Nanotechnology
Cell and Tissue Engineering
Immunostaining of E-cadherin in MCF7 cultured in microfluidic channels
Artificial Organs and Implants
33. K. Schumacher, Y. M. Khong, S. Chang, J. Ni, W. X. Sun and H. Yu Perfusion Culture Improves the Maintenance of Cultured Liver Tissue Slices Tissue Engineering, 13 (2007) 197-205. 34. F. Wen, S. Chang, Y. C. Toh, S. H. Teoh and H. Yu Preparation of Biocompatible Poly (Lacticco-glycolic Acid) Fiber Scaffolds for Rat Liver Cells Cultivation Materials Science and Engineering: C, 27 (2007) 285-292.
Annual Report 2006
29. Y. C. Toh, C. Zhang, J. Zhang, Y. M. Khong, S. Chang, V. D. Samper, D. V. Noort, D. W. Hutmacher and H. Yu A Novel 3D Mammalian Cell PerfusionCulture System in Microfluidic Channels Lab on a Chip, 7 (2007) 302-309.
Institute of Bioengineering and Nanotechnology
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30. Y. N. Du, S. M. Chia and H. Yu 3D Hepatocyte Monolayer on Hybrid RGD/ Galactose Substratum Biomaterials, 27 (2006) 5669-5680. 31. S. S. S. Ng, R. B. Han, J. Ni, S. Chang, W. Hunziker, A. B. Goryachev, S. H. Ong and H. Yu Improved Hepatocyte Excretory Function by Immediate Presentation of Polarity Cues Tissue Engineering, 12 (2006) 2181-2191. 32. Y. C. Toh, S. S. S. Ng, Y. M. Khong, X. Zhang, Y. J. Zhu, P. C. Lin, C. M. Ten, W. X. Sun and H. Yu Cellular Responses to a Nanofibrous Environment Nano Today, 1 (2006) 34-43.
35. H. L. Foo, A. Taniguchi, H. Yu, T. Okano and S. H. Teoh Catalytic Surface Modification of Rollmilled poly(ε-caprolactone) Biaxially Stretched to Ultra-thin Dimension Materials Science and Engineering: C, 27 (2007) 299-303. 36. S. M. Chia, C. M. Tan and H. Yu Novel Cell Culture Supplements for Enhanced Hepatocyte Functions Proceedings of Regenerate World Congress on Tissue Engineering and Regenerative Medicine Pittsburgh, Pennsylvania, USA, April 2006. 37. S. M. Chia, F. Y. Kuan and H. Yu Thrombospondin-1 is a Key TGF-β1 Activator for Hepatic Stellate Cells in Liver Fibrosis Proceedings of Keystone Symposium “Molecular Mechanisms in Fibrosis; From Bench to Bedside”, Tahoe City, California, USA, March 2007.
43. D. K. Yi, S. S. Lee and J. Y. Ying Synthesis and Applications of Magnetic Nanocomposite Catalysts Chemistry of Materials, 18 (2006) 2459-2461.
38. J. Xu and J. Y. Ying A Highly Active and Selective Nanocomposite Catalyst for C7+ Paraffin Isomerization Angewandte Chemie International Edition, 45 (2006) 6700-6704.
45. H. F. Vanbrocklin, S. M. Hanrahan, J. D. Enas, E. Nandanan and J. P. O’Neil Mitochondrial Avid Radioprobes. Preparation and Evaluation of 7’(Z)-[(125)I]iodorotenone and 7’(Z)-[(125)I]iodorotenol Nuclear Medicine and Biology, 34 (2007) 109-116. 46. J. Y. Ying and N. AbuBakar Research in Bioengineering and Nanotechnology Proceedings of University of Tokyo Symposium on NanoBio Integration, Tokyo, Japan, December 2006.
40. J. T. McCue and J. Y. Ying SnO2-In2O3 Nanocomposites as Semiconductor Gas Sensors for CO and NOx Detection Chemistry of Materials, 19 (2007) 1009-1015. 41. S. S. Lee, S. Hadinoto and J. Y. Ying Improved Enantioselectivity of Immobilized Chiral Bisoxazolines by Partial Precapping of Siliceous Mesocellular Foam Support with Trimethylsilyl Groups Advanced Synthesis and Catalysis, 348 (2006) 1248-1254.
Magnetic nanocomposite catalysts for pharmaceutical synthesis
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Annual Report 2006
39. B. A. Wilhite, S. E. Weiss, J. Y. Ying, M. A. Schmidt and K. F. Jensen High-Purity Hydrogen Generation in a Microfabricated 23 wt % Ag-Pd Membrane Device Integrated with 8:1 LaNi0.95Co0.05O3/ Al2O3 Catalyst Advanced Materials, 18 (2006) 1701-1704.
44. S. S. Lee and J. Y. Ying Siliceous Mesocellular Foam-Supported Chiral Bisoxazoline: Application to Asymmetric Cyclopropanation Journal of Molecular Catalysis A: Chemical, 256 (2006) 219-222.
Institute of Bioengineering and Nanotechnology
Pharmaceuticals Synthesis and Nanobiotechnology
42. Y. Zhang, L. Zhao, S. S. Lee and J. Y. Ying Enantioselective Catalysis over Chiral Imidazolidin-4-one Immobilized on Siliceous and Polymer-Coated Mesocellular Foams Advanced Synthesis and Catalysis, 348 (2006) 2027-2032.
Medical and Biological Devices
52. M. Manimaran, F. E. H. Tay and K. C. Chaw Cell Deformation in Cancer Metastasis: A BioMEMS Based Approach Journal of Physics: Conference Series, 34 (2006) 1143-1147. 53. K. C. Chaw, M. Manimaran, F. E. H. Tay and S. Swaminathan Three-Dimensional (3D) Extra-Cellular Matrix Coating of a Microfluidic Device Journal of Physics: Conference Series, 34 (2006) 747-751.
Annual Report 2006
47. L. Novak, P. Neuzil, J. Pipper, Y. Zhang and S. H. Lee An Integrated Fluorescence Detection System for Lab-on-a-Chip Applications Lab-on-a-Chip, 7 (2007) 27-29.
Institute of Bioengineering and Nanotechnology
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48. C. Iliescu, L. Yu, G. Xu and F. E. H. Tay A Dielectrophoretic Chip with a 3D Electric Field Gradient Journal of Microelectromechanical Systems, 15 (2006) 1506-1513. 49. M. Avram, A. Avram and C. Iliescu Biodynamical Analysis Microfluidic System Microelectronic Engineering, 83 (2006) 1686-1689. 50. C. Iliescu, F.E.H. Tay and J. Wei Low Stress and High Deposition Rate of PECVD - SiNx Layers Using High Power and High Frequency for MEMS Applications Journal of Micromechanics and Microengineering, 16 (2006) 869-874. 51. S. Ezhilvalavan, Z. Zhang, J. Loh and J. Y. Ying Microfabrication of PZT Force Sensors for Minimally Invasive Surgical Tools Journal of Physics: Conference Series, 34 (2006) 979-984.
54. M. N. Nyan, F. E. H. Tay, M. Manimaran and K. H. W. Seah Garment-based Detection of Falls and Activities of Daily Living Using 3-Axis MEMS Accelerometer Journal of Physics: Conference Series, 34 (2006) 1059-1067. 55. G. L. Xu, M. B. Chan, C. Yang, P. Sukumar, M. Choolani and J. Y. Ying Design and Fabrication of a Microfluidic Device for Fetal Cells Dielectrophoretic Properties Characterization Journal of Physics: Conference Series, 34 (2006) 1106-1111. 56. H. K. Tay, D. Lee, G. L. Xu and C. Yang Design and Fabrication of a Flow Delivery Microdevice with Asymmetric Microelectrodes Pairs Journal of Physics: Conference Series, 34 (2006) 1112-1116. 57. J. Ji, F. E. H. Tay, J. Miao and C. Iliescu Microfabricated Silicon Microneedle Array for Transdermal Drug Delivery Journal of Physics: Conference Series, 34 (2006) 1127-1131. 58. L. Yu, Y. Y. Lee, F. E. H. Tay and C. Iliescu Spray Coating of Photoresist for 3D Microstructures with Different Geometries Journal of Physics: Conference Series, 34 (2006) 937-942.
63. J. Ji, F. E. H. Tay, J. M. Miao and C. Iliescu Microfabricated Microneedle with Porous Tip for Drug Delivery Journal of Micromechanics and Microengineering, 16 (2006) 958-964.
60. L. Yu, F. E. H. Tay, G. Xu, B. Chen, M. Avram and C. Iliescu Adhesive Bonding with SU-8 at Wafer Level for Microfluidic Devices Journal of Physics: Conference Series, 34 (2006) 776-781.
64. P. Neuzil and R. Nagarajan Formation of Sharp AFM Tips by Single Step Etching Journal of Microelectromechanical Systems, 16 (2006) 1298-1300.
61. P. L. Ong, J. Wei, F. E. H. Tay and C. Iliescu A New Fabrication Method for Low Stress PECVD - SiNx Layers Journal of Physics: Conference Series, 34 (2006) 764-769. 62. A. M. Avram, M. Avram, A. Bragaru, R. Vasilco and C. Iliescu A Biodynamic Microsystem for Fluids Viscosity Measurements Journal of Physics: Conference Series, 34 (2006) 82-88.
65. P. Neuzil, J. Pipper and T. M. Hsieh Disposable Real-time MicroPCR Device: Lab-on-a-chip at a Low Cost Molecular BioSystems, 2 (2006) 292-298.
Microneedle array for transdermal drug delivery
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Annual Report 2006
66. C. P. Ng, D. G. Guo, D. B. M. H. Mohammad, M. N. Nyan, J. S. Wei, O. Andojo and F. E. H. Tay Overview of MEMSWear II - Incorporating MEMS Technology into Smart Shirt for Geriatric Care Journal of Physics: Conference Series, 34 (International MEMS Conference) (2006) 1079-1085.
Institute of Bioengineering and Nanotechnology
59. Y. Y. Ong, B. T. Chen, F. E. H. Tay and C. Iliescu Process Analysis and Optimization on PECVD Amorphous Silicon on Glass Substrate Journal of Physics: Conference Series, 34 (2006) 812-817.
67. C. P. Ng, D. G. Guo, D. B. M. H. Mohammad and F. E. H. Tay MEMSWear - Biomonitoring - Incorporating Sensors into Smart Shirt for Wireless Sentinel Medical Detection and Alarm Journal of Physics: Conference Series, 34 (International MEMS Conference) (2006) 1068-1072. 68 M. N. Nyan, F. E. H. Tay, A. W. Y. Tan and K. H. W. Seah Distinguishing Fall Activities from Normal Activities by Angular Rate Characteristics and High-Speed Camera Characterization Medical Engineering and Physics, 28 (2006) 842-849. 69. P. Neuzil, C.Y. Zhang, J. Pipper, S. Oh and L. Zhuo Ultra Fast Miniaturized Real-Time PCR: 40 Cycles in Less Than Six Minutes Nucleic Acid Research, 34 (2006) e77.
Annual Report 2006
70. M. N. Nyan, F. E. H. Tay, K. H. W. Seah and Y. Y. Sitoh Classification of Gait Patterns in the TimeFrequency Domain Journal of Biomechanics, 39 (2006) 2647-2656. 71. C. Iliescu, F. E. H. Tay, G. L. Xu, L. M. Yu and V. Samper A Dielectrophoretic Chip Packaged at Wafer Level Microsystem Technologies, 12 (2006) 987-992. 72. F. E. H. Tay, C. Iliescu, J. Jing and J. M. Miao Defect-Free Wet Etching Through Pyrex Glass Using Cr/Au Mask Microsystem Technologies 12 (2006) 935-939.
Institute of Bioengineering and Nanotechnology
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Virtual reaction chamber for disease diagnostics
73. F. E. H. Tay, C. Iliescu and H. T. Chua Nanotips Array for Thermoelectric Coolers Fabricated Using Notching Effect of the Reflected Charges on Mask Romanian Journal of Information Science and Technology, 9 (2006) 99-106.
75. K. C. Chaw, M. Manimaran, F. E. H. Tay and S. Swaminathan A Quantitative Observation and Imaging of Single Tumor Cell Migration and Deformation Using a Multi-Gap Microfluidic Device Representing the Blood Vessel Microvascular Research, 72 (2006) 153-160. 76. C. Iliescu Wet Etching of Glass for MEMS Applications Romanian Journal of Information Science and Technology, 9 (2006) 285-310. 77. C. Iliescu, B. Chen, J. Miao, M. Avram and A. M. Avram Inertial Sensors with Tunable Range Romanian Journal of Information Science and Technology, 9 (2006) 311-320.
79. F. E. H. Tay, L. Yu, A. J. Pang and C. Iliescu Electrical and Thermal Characterization of a Dielectrophoretic Chip with 3D Electrodes for Cells Manipulation Electrochimica Acta, 52 (2007) 2862-2868. 80. B. Chen and J. Miao Influence of Deep RIE Tolerances on CombDrive Actuators Performance Journal of Physics D: Applied Physics, 40 (2007) 970-976.
82. D. P. Poenar, C. Iliescu and J. Liang Microfluidic Device for Electrical Cell Characterization Fabricated by Parylenebased Wafer-to-Wafer Bonding Proceedings of Asia-Pacific Conference of Transducers and Micro-Nano Technologies (APCOT), Singapore, June 2006. 83. C. Iliescu, G. Xu, F. C. Loe and F. E. H. Tay A 3D Dielectrophoretic Chip-Filter with Parallel Plate Electrodes Proceedings of Micromachines Europe (MME2006), Southampton, United Kingdom, September 2006. 84. L. Yu, C. Iliescu, F. E. H. Tay and B. Chen SU8 Adhesive Bonding Using Contact Imprinting Proceedings of the International Semiconductor Conference (CAS 2006), 29th Edition, Sinaia, Romania, September 2006. 85. F. E. H. Tay, M. N. Nyan, D. G. Guo, C. P. Ng, L. Xu and C. T. Tan MEMSWear — Biomonitoring System in a Body Area Network (BAN) Proceedings of 2006 International Semiconductor Conference, Romania, September 2006. 86. T. M. Hsieh, Y. Zhang, J. Pipper and P. Neuzil PCR by Moving a Free Droplet over Different Temperature Zones Proceedings of the MicroTAS Conference, Tokyo, Japan, November 2006.
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Annual Report 2006
78. C. Iliescu, F. E. H. Tay and J. Miao Strategies in Deep Wet Etching of Pyrex Glass Sensors and Actuators A, 133 (2007) 395-400.
81. G. Tresset Self-Organized Lipid-DNA Containers: Accumulation of DNA Mediated by Divalent Cations Proceedings of the 4th International Society of Electrochemistry Spring Meeting, Singapore, April 2006.
Institute of Bioengineering and Nanotechnology
74. C. Iliescu, M. Avram, J. Miao and F. E. H. Tay A New Fabrication Process for Inertial Sensors with Tunable Range Romanian Journal of Information Science and Technology, 9 (2006) 83-90.
87. J. Pipper, P. Neuzil and T. M. Hsieh Moving, Mixing, and Filtration of Droplets by Magnetic Fields Proceedings of the MicroTAS conference, Tokyo, Japan, November 2006. 88. L. Novak, P. Neuzil, J. Pipper, L. Ng and C. Y. Zhang A Palm-Sized Real-Time (RT) PCR Proceedings of the MicroTAS Conference, Tokyo, Japan, November 2006. 89. P. Neuzil, L. Novak, J. Pipper, S. H. Lee, L. Ng and C. Y. Zhang Avian Influenza Virus Detection by a PalmSized Real-Time RT-PCR Proceedings of NanoTech 2006, Montreux, Switzerland, November 2006.
Annual Report 2006
90. P. Neuzil, J. Pipper, C. Y. Zhang, L. Novak, S, H. Lee, J. Hsieh, L. Ng and T. Karasek Disposable Real-Time MicroPCR System Proceedings of the Central European Capillary Electrophoresis (CECE 2006), Brno, Czech Republic, November 2006.
Institute of Bioengineering and Nanotechnology
40
91. J. Loh, G. L. Xu, J. Hsieh, R. Qi, D. Lee, C. Y. Zhang and J. Y. Ying Making Molecular Diagnosis and Biosample Preparation a Breeze through LabVIEWTM Inspired System Automation Proceedings of the 2006 ASEAN Virtual Instrumentation Applications Contest, December 2006.
92. D. Lee, G. Xu, H. K. Tay, C. Yang and J. Y. Ying Microfluidic Device with Asymmetric Electrodes for Cell and Reagent Delivery SPIE Conference Proceeding Vol. 6415, Microand Nanotechnology: Materials, Processes, Packaging, and System III, Adelaide, Australia, December 2006. 93. C. Iliescu, B. Chen and J. Miao Deep Wet Etching-Through of 1 mm Pyrex Glass Wafer for Microfluidics Applications Proceedings of the 20th IEEE Conference on Micro Electro Mechanical Systems (MEMS’07), Kobe, Japan, January 2007. 94. H. Zhang, Y. Y. Lee, K. J. Leck, N. Y. Kim and J. Y. Ying Recyclable Hydrophilic-Hydrophobic Micropatterns on Glass for Microarray Applications Langmuir, 23 (2007) 4728-4731.
99. Y. Zheng, S. Gao and J. Y. Ying Synthesis and Cell-Imaging Applications of Glutathione-Capped CdTe Quantum Dots Advanced Materials, 19 (2007) 376-380.
95. C. Papan, B. Boulat, S. S. Velan, S. E. Fraser and R. E. Jacobs Time-Lapse Tracing of Mitotic Cell Divisions in the Early Xenopus Embryo Using Microscopic MRI Developmental Dynamics, 235 (2006) 3059-3062.
97. G. Ho, C. Y. Zhang and L. Zhuo Non-invasive Imaging of Transgenic GFP Expression in Neonatal Mouse Brain Proceedings of SPIE Volume 6424, San Jose, California, March 2007.
101. Y. Qu, W. Ji, Y. Zheng, and J. Y. Ying Auger Recombination and Intraband Absorption of Two-Photon-Excited Carriers in Colloidal CdSe Quantum Dots Applied Physics Letters, 90 (2007) 133112-1133112-3.
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Annual Report 2006
96. C. Papan, B. Boulat, S. S. Velan, S. E. Fraser and R. E. Jacobs Two-Dimensional and Three-Dimensional Time-Lapse Microscopic Magnetic Resonance Imaging of Xenopus Gastrulation Movements Using Intrinsic Tissue-Specific Contrast Developmental Dynamics, 236 (2007) 494-501.
100. J. He, W. Ji, J. Mi, Y. Zheng and J. Y. Ying Three-Photon Absorption in Water-Soluble ZnS Nanocrystals Applied Physics Letters, 88 (2006) 181114-1181114-3.
Institute of Bioengineering and Nanotechnology
Bioimaging and Biosensing
98. S. T. Selvan, P. K. Patra, C. Y. Ang and J. Y. Ying Synthesis of Silica-Coated Semiconductor and Magnetic Quantum Dots and Their Use in the Imaging of Live Cells Angewandte Chemie International Edition, 46 (2007) 2448-2452.
Dual staining of cell nucleolus and cytoplasm by ultrafine glutathione-capped quantum dots
Invited Conference Presentations and Seminars
1.
2.
3.
F. E. H. Tay MEMSWear – Wearable Biomonitoring System Distributed Diagnosis and Home Healthcare, Arlington, Virginia, USA, April 2-4, 2006. Plenary Lecture. J. Y. Ying Synthesis and Processing of Nanoparticles for Bioengineering Applications 4th International Society of Electrochemistry Spring Meeting, Singapore, April 17-20, 2006. Plenary Lecture. J. Y. Ying Research in Bioengineering and Nanotechnology Raffles Junior College Science Symposium 2006, Singapore, May 3, 2006. Keynote Lecture.
7.
8.
9.
4.
Annual Report 2006
5.
6. 42
Institute of Bioengineering and Nanotechnology
J. Y. Ying Microfabrication and Nanostructure Processing of Advanced Biological Systems International MEMS Conference, Singapore, May 9-12, 2006. Plenary Lecture. J. Y. Ying Nanostructure Processing of Advanced Catalysts CONCORDE Conference on “Catalytic NanoOxides R&D in Europe: Present and Future,” Seville, Spain, May 17-19, 2006. Plenary Lecture. Y. Y. Yang, S. Moochhala, L. S. Wang, C. W. Tan, D. Tan and B. Zhao Sustained-Release of Caffeine from a Polymeric Tablet Matrix: In Vitro and In Vivo Studies Defence Research and Development Seminar, Singapore, May 23, 2006. Invited Talk.
J. Y. Ying Research in Bioengineering and Nanotechnology Ministry of Education Principal’s Forum, Singapore, May 26, 2006. Panel Speaker. P. Y. Chow and Y. Y. Yang Contact Lenses for Ophthalmic Drug Delivery: Achieving Controlled Release with Novel Nanostructured Polymer Matrix 3rd IUPAC-Sponsored International Symposium on Macro- and Supramolecular Architectures and Materials (MAM-06): Practical Nano-Chemistry and Novel Approaches, Tokyo, Japan, May 28June 1, 2006. Invited Talk. J. Y. Ying Nanostructure Processing of Advanced Catalysts 11th International Ceramics Congress and 4th Forum on New Materials, Sicily, Italy, June 4-9, 2006. Invited Talk.
10. J. Y. Ying Nanostructure Processing of Biomaterials and Biosystems Special Biomaterial Symposium, Turku, Finland, June 5, 2006. Invited Talk. 11. J. Y. Ying Nanostructure Processing of Advanced Catalysts and Biomaterials 2nd APNF International Symposium on Nanotechnology in Environmental Protection and Pollution, Hong Kong, June 18-21, 2006. Plenary Lecture. 12. N. Y. Kim The Role of Surface Chemistry for Microarrays, Microfluidics and Biosensors Samsung Electro-Mechanics, Suwon, Korea, June 20, 2006. Invited Talk.
14. J. Y. Ying Nanostructure Processing of Biomaterials and Biosystems 1st International Conference of Nanobiomedical Technology and Structural Biology, Chengdu, China, June 25-28, 2006. Invited Talk. 15. E. Chow Contact Lenses for Ocular Drug Delivery: Achieving Controlled Release with Novel Nanostructured Polymer Matrix Drug Delivery and Licensing Symposium, Marriott Hotel, Singapore, July 10-12, 2006. Invited Talk.
17. J. Y. Ying, S. S. Lee, Y. Zhang, Y. Han, J. Lim, L. Zhao and S. N. Riduan Supramolecular Templating of Nanoporous Catalysts 5th International Mesostructured Materials Symposium (IMMS 2006), Shanghai, China, August 5-7, 2006. Invited Talk. 18. H. Yu Immediate-Overlay Sandwich Perfusion Sustains Hepatocyte Polarity and Functions 7th Asian Symposium on Biomedical Materials (ASBM-7), Jeju Island, Korea, August 20, 2006. Invited Talk.
20. H. Yu Engineering Extra-Cellular (EC) Environments EWHA Woman’s University, Division of Nano Science and Department of Life Science, Seoul, Korea, August 24, 2006. Invited Talk. 21. S. Wang, J. Zeng , X. Wang and E. S. E. Luo Self-Assembled Ternary Complexes of Plasmid DNA, Low Molecular Weight Polyethylenimine and Functional Peptides as Gene Delivery Vectors Office of Life Sciences-National University of Singapore Nanoscience and Nanotechnology Initiative Workshop on Nanobiotechnology and Nanomedicine, National University of Singapore, Singapore, September 1, 2006. Invited Talk. 22. J. Y. Ying, S. S. Lee, Y. Zhang, Y. Han, J. Lim, L. Zhao and S. N. Riduan Synthesis and Application of Mesoporous Materials Symposium on “Nano-scale Science and Technology in Biomolecular Catalysis,” American Chemical Society Meeting, San Francisco, USA, September 10-14, 2006. Invited Talk. 23. C. Iliescu Microfluidics in Glass: Technologies and Applications International Conference on Microelectronics, Devices and Materials (MIDEM 2006), Slovenia, September 13-15, 2006. Invited Talk.
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Annual Report 2006
16. J. Y. Ying Research Opportunities in Bioengineering and Nanotechnology Biotechnology Fair 2006, Singapore, August 2-3, 2006. Guest-of-Honor.
19. J. Y. Ying Nanostructure Processing of Advanced Biomaterials 8th International Conference on Nanostructured Materials, Bangalore, India, August 20-25, 2006. Invited Talk.
Institute of Bioengineering and Nanotechnology
13. J. Y. Ying Research and Commercialization of Nanostructured Catalysts and Biomaterials Workshop on Commercialization of Nanotechnology: From Laboratory to Commercial Products, Hong Kong, June 22, 2006. Invited Talk.
24. K. Schumacher Tissue Engineering of Tubular Structures German National Science Foundation (DFG) Symposium on Regenerative Medicine, Dresden, Germany, September 19, 2006. Invited Talk.
30. J. Y. Ying The Science of the Future Raffles Girls’ School Annual Staff Seminar on “Education for the Future,” Singapore, November 10, 2006. Plenary Lecture.
25. J. Loh, K. Schumacher, A. Schumacher, S.-H. Kan and J. Y. Ying Engineering Homogeneous Micromagnetic Fields for Cell Patterning Symposium on “Materials Processing for Medical Devices,” ASME International Conference on Manufacturing Science and Engineering, Ypsilanti, Michigan, USA, October 8-11, 2006. Invited Talk.
31. J. Y. Ying Supramolecular Templating of Nanoporous Catalysts Symposium on “Nano-Scale Science and Engineering in Biomolecular Catalysis,” American Institute of Chemical Engineers Annual Meeting, San Francisco, California, USA, November 12-17, 2006. Invited Talk.
Annual Report 2006
26. S. Wang Targeted Gene Delivery into the Central Nervous System 7th China-Singapore Conference of Life Sciences and Biotechnology, Nankai University, Tianjin, China, October 12-13, 2006. Invited Talk.
Institute of Bioengineering and Nanotechnology
44
27. Y. Y. Yang Smart Polymer Nanoparticles for Drug and Gene Delivery South China University of Technology, China, October 19, 2006. Invited Lecture. 28. J. Y. Ying Research Opportunities in Bioengineering and Nanotechnology World Nano-Economic Congress Singapore, Singapore, November 1-2, 2006. Guest-ofHonor. Keynote Lecture. 29. P. Neuzil, J. Pipper, C. Y. Zhang, L. Novak, S. H. Lee, J. Hsieh, L. Ng and T. Karasek Disposable Real-Time MicroPCR System Institute of Molecular Genetics, Prague, Czech Republic, November 9, 2006. Invited Lecture.
32. P. Neuzil, L. Novak, J. Pipper, S. Lee, L. Ng and C. Y. Zhang Avian Influenza Virus Detection by a PalmSized Real-Time RT-PCR Central European Capillary Electrophoresis 2006, Brno, Czech Republic, November 14-16, 2006. Invited Talk. 33. J. Loh, G. L. Xu, J. Hsieh, R. Qi, D. Lee, C. Y. Zhang and J. Y. Ying A Fully Integrated Biochip for Avian Flu Detection 2006 Bioengineering Seminar, Singapore Polytechnic, Singapore, November 22, 2006. Invited Talk. 34. G. Ho In Vivo Biological Imaging 2006 Bioengineering Seminar, Singapore Polytechnic, Singapore, November 22, 2006. Invited Talk. 35. H. Yu, Y. N. Du, Y. C. Toh, S. Ng, X. Zhang, J. Heng, S. M. Ong, S. M. Chia and W. X. Sun Imaging Cellular Niche 9th International Conference on “Optics Within Life Science (OWLS9),” National Yang-Ming University, Taipei, Taiwan, November 26-29, 2006. Invited Talk.
37. J. Y. Ying Nanostructure Processing of Advanced Biomaterials and Biosystems University of Tokyo Symposium on NanoBio Integration, Tokyo, Japan, December 4-7, 2006. Invited Talk. 38. H. Yu, Y. N. Du, Y. C. Toh, S. Ng, X. Zhang, J. Heng, S. M. Ong, S. M. Chia and W. X. Sun Engineering and Imaging Extra-Cellular Environments University of Tokyo Symposium on NanoBio Integration, Tokyo, Japan, December 4-7, 2006. Invited Talk.
40. J. Y. Ying Nanostructure Processing of Advanced Catalysts and Biomaterials Symposium on Recent Advances on Nanoscale Materials Research, Santa Barbara, California, USA, December 8, 2006. Invited Talk. 41. C. Iliescu, J. Wei, B. Chen, P. L. Ong and F. E. H. Tay Low Stress Silicon Nitride Layers for MEMS Applications SPIE Conference on “Smart Materials, Nano-, and Micro-Smart Systems,� Adelaide, Australia, December 10-13, 2006. Keynote Lecture.
43. Y. Y. Yang, Y. Wang, S. J. Gao, H. S. Yoon, W.H. Ye and C.-Y. Ke Cationic and Biodegradable Polymer Micelles for Co-Delivery of Anticancer Drugs and Nucleic Acids International Symposium for Chinese Organic Chemists (ISCOC-9) and International Symposium for Chinese Inorganic Chemists (ISCIC-6), Singapore, December 17-21, 2006. Invited Talk.
45
44. Y. Zhang, L. Zhao and J. Y. Ying Mesoporous Materials Supported Heterogeneous Enantioselective Organo Catalysis International Symposium for Chinese Organic Chemists (ISCOC-9) and International Symposium for Chinese Inorganic Chemists (ISCIC-6), Singapore, December 17-21, 2006. Invited Talk. 45. H.-H. Yu, E. M. Ali and J. Y. Ying Toward Poly (3, 4-Ethylenedioxythiophene) (PEDOT) Sensors International Symposium for Chinese Organic Chemists (ISCOC-9) and International Symposium for Chinese Inorganic Chemists (ISCIC-6), Singapore, December 17-21, 2006. Invited Talk. 46. J. Y. Ying Nanostructure Processing of Advanced Catalysts and Biomaterials California NanoSystems Institute, University of California, Los Angeles, California, USA, December 11, 2006. Invited Seminar.
Annual Report 2006
39. J. Y. Ying Nanostructure Processing of Advanced Catalytic Materials 4th Asia Pacific Congress on Catalysis, Singapore, December 6-8, 2006. Plenary Lecture.
42. J. Y. Ying Supramolecular Templating of Nanoporous Catalysts International Symposium for Chinese Organic Chemists (ISCOC-9) and International Symposium for Chinese Inorganic Chemists (ISCIC-6), Singapore, December 17-21, 2006. Plenary Lecture.
Institute of Bioengineering and Nanotechnology
36. Y. Y. Yang, Y. Wang, W.-H. Ye, S. J. Gao and H. S. Yoon Co-Delivery of Anticancer Drug and Gene Using Cationic Polymer Core-Shell Nanoparticles for Improved Cancer Therapy Annual Meeting of the Korean Society for Pharmaceutical Science and Technology (KSPST), Seoul, Korea, November 30-December 1, 2006. Invited Talk.
Annual Report 2006 Institute of Bioengineering and Nanotechnology
46
47. N. Erathodiyil and J. Y. Ying Research in Bioengineering and Nanotechnology Department of Chemistry, Christ College, Irinjalakuda and University of Calicut, Kerala, India, December 18, 2006. Invited Seminar.
52. J. Y. Ying Microfabrication and Nanostructure Processing of Advanced Biological Systems IEEE International Conference on Nano/MicroEngineered and Molecular Systems, Bangkok, Thailand, January 16-19, 2007. Keynote Lecture.
48. E. Nandanan Bioengineering and Nanotechnology for Increasing the Health and Longevity of Human Life Christ College, Irinjalakuda and University of Calicut, Kerala, India, December 18, 2006. Fr. Jose Stephen Endowment Lecture.
53. J. Y. Ying, E. Chow, A. C. A. Wan and K. M. Schumacher Nanostructure Processing of Advanced Biomaterials 1st Asia-Association for Research in Vision and Ophthalmology (AVRO) Meeting, Singapore, March 2, 2007. Invited Talk.
49. H.-H. Yu Nanomaterials for Luminescent and Electrochemical Biosensors Department of Chemistry, National Tsing-hua University, Taiwan, December 27, 2006. Invited Talk.
54. E. Chow Designing Small Solutions to Big Problems 6th Anglo-Chinese School (Independent) Life Science Symposium, Singapore, March 2, 2007. Invited Talk.
50. H.-H. Yu Nanoscience and Nanotechnology for Homeland Security Department of Applied Chemistry, Chung Cheng Institute of Technology, National Defense University, Taiwan, December 29, 2006. Invited Talk.
55. Y. Y. Yang, W. Y. Seow, L. H. Liu, S. Q. Liu, N. Wiradharma and A. Lee Polymer Nanocarriers for Delivery of Anticancer Drugs and Genes Department of Clinical Research, Singapore General Hospital, March 16, 2007. Invited Talk.
51. E. Chow and J. Y. Ying Novel Nanostructured, Bicontinuous Microemulsion-based Polymer – A Material with Important Ophthalmic Implications Singapore Eye Research Institute, Singapore, January 10, 2007. Invited Talk.
56. J. Y. Ying Nanostructured Materials, Sensors and Devices 2nd Annual Diagnostics Asia, Singapore, March 27-28, 2007. Keynote Lecture.
Other Conference Presentations
2.
3.
Y. G. Zheng, E. M. Ali, S. Gao and J. Y. Ying Glutathione-capped CdTe Quantum Dots: Synthesis and Cell Imaging Applications 2006 Materials Research Society Spring Meeting, San Francisco, California, USA, April 19-22, 2006. Oral Presentation. E. Chow and Y. Y. Yang Contact Lenses for Ocular Drug Delivery: Achieving Controlled Release with Novel Nanostructured Polymer Matrix 3rd Interational Union of Pure and Applied Chemistry (IUPAC)-sponsored International Symposium on Macro- and Supramolecular Architectures and Materials (MAM-06): Practical Nano-Chemistry and Novel Approaches, Tokyo, Japan, May 28-31, 2006. Oral Presentation. S.-L. Lo and S. Wang TAT Peptide Conjugates of Low Molecular Weight Polyethylenimine as Effective NonViral Gene Delivery Vectors American Society of Gene Therapy 9th Annual Meeting, Baltimore, Maryland, USA, May 31-June 4, 2006. Poster Presentation.
6.
7.
8.
5.
C.-Y. Wang and S. Wang A New Vector Based on Baculovirus was Effective in Inhibiting Glioma Cell Growth in the Rat Brain American Society of Gene Therapy 9th Annual Meeting, Baltimore, Maryland, USA, May 31-June 4, 2006. Poster Presentation. Y. G. Zhang, L. Zhao, S. S. Lee and J. Y. Ying Friedel-Crafts Alkylation and Diels-Alder Cycloaddition Over Siliceous MCFSupported Chiral Imidazolidin-4-one International Mesoporous Materials Symposium (IMMS 2006), Shanghai, China, August 5-7, 2006. Poster Presentation.
S. M. Ong and H. Yu Engineering 3-D Cellular Constructs using Intercellular Polymeric Linkers 7th Asian Symposium for Biomedical Materials, Jeju Island, Korea, August 20-23, 2006. Oral Presentation. C. Iliescu, G. Xu, F. C. Loe and F. E. H. Tay A 3D Dielectrophoretic Chip-Filter with Parallel Plates Electrodes Micromachining, Micromechanics and Microsystems (MME 2006), Southampton, United Kingdom, September 3-5, 2006. Oral Presentation. A. C. A. Wan, K. M. Schumacher, A. Schumacher, S. Pek, S. Gao, B. C. U. Tai and J. Y. Ying RGD-modified Scaffolds for the Guided Formation of Epithelial Structures 2nd International Conference of Bioengineering and Nanotechnology (ICBN 2006), Santa Barbara, California, USA, September 5-7, 2006. Poster Presentation.
10. J. Y. Ying, K. Schumacher, J. Loh, Y. Han, S. S. Lee, Y. Zheng and S. T. Selvan Nanostructure Processing of Biomaterials and Biosystems 2nd International Conference of Bioengineering and Nanotechnology (ICBN 2006), Santa Barbara, California, USA, September 5-7, 2006. Oral Presentation.
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Annual Report 2006
9. 4.
Y. N. Du, R. B. Han, S. S. Ng, S. M. Chia and H. Yu Identification and Stabilization of a Novel 3D Hepatocyte Monolayer Configuration for Hepatocyte-based Applications Cambridge Healthtech Institute (CHI) Conference on Tissue Models for Therapeutic Development, Boston, Massachusetts, USA, August 14-17, 2006. Poster Presentation.
Institute of Bioengineering and Nanotechnology
1.
11. Y. Y. Yang, M. Khan, P. Chan and S. H. Eng Novel Chitosan-based Non-Viral Vectors for Gene Delivery 2nd International Conference of Bioengineering and Nanotechnology (ICBN 2006), Santa Barbara, California, USA, September 5-7, 2006. Oral Presentation. 12. C. Iliescu, G. Xu, F. C. Loe and F. E. H. Tay A 3-D iDEP Chip-Filter 2nd International Conference of Bioengineering and Nanotechnology (ICBN 2006), Santa Barbara, California, USA, September 5-7, 2006. Oral Presentation.
Annual Report 2006
13. R. Kraut, A. Lim and A. Wright Motorneuron Defects in a Neurodegenerative Lysosomal Transport Mutant, Blue Cheese European Conference on Drosophila Neurobiology, Leuven, Belgium, September 6, 2006. Oral Presentation.
Institute of Bioengineering and Nanotechnology
48
14. J. H. Lim, S. S. Lee, S. N. Riduan and J. Y. Ying Development of MCF-Supported Catalysts for Ring-Closing Metathesis (RCM) Reactions 232nd American Chemical Society Meeting and Exposition, San Francisco, California, USA, September 10-14, 2006. Oral Presentation. 15. H.-H. Yu, N. R. Jana, E. M. Ali, Y. G. Zheng and J. Y. Ying ZnO Luminescent Nanoparticle-based Biosensors 232nd American Chemical Society Meeting and Exposition, San Francisco, California, USA, September 10-14, 2006. Oral Presentation. 16. Y. Y. Yang, W. Y. Seow and J. M. Xue Multi-Functional Polymer Micelles for Targeted Intracellular Delivery of an Anticancer Drug 232nd American Chemical Society Meeting and Exposition, San Francisco, California, USA, September 10-14, 2006. Oral Presentation.
17. B. T. Tan and R. S. Ruan The Role of Bone Marrow Derived Stem Cells in Inner Ear Repair Inner Ear Biology Workshop, Montpellier, France, September 17-20, 2006. Oral Presentation. 18. C. Papan, N. S. S. Kwan and L. Zhuo Towards Metabolomic Profiling of Zebrafish Embryonic Development Advances in Metabolic Profiling, London, United Kingdom, October 18-19, 2006. Poster Presentation. 19. J. Pipper, P. Neuzil and T. M. Hsieh Moving, Mixing, and Filtration of Droplets by Magnetic Fields MicroTAS 2006, Tokyo, Japan, November 5-9, 2006. Poster Presentation. 20. L. Novak, P. Neuzil, J. Pipper, C. Zhang and V. Zahlava A Palm-Sized Real-Time RT-PCR System MicroTAS 2006, Tokyo, Japan, November 5-9, 2006. Poster Presentation. 21. T.-M. Hsieh, Y. Zhang, J. Pipper and P. Neuzil PCR by Moving a Free Droplet over Different Temperature Zones MicroTAS 2006, Tokyo, Japan, November 5-9, 2006. Poster Presentation. 22. P. Neuzil, L. Novak, J. Pipper, S. Lee, L. Ng and C. Y. Zhang Detection of Avian Influenza Virus by PalmSized RT-PCR System Nanotech - Micro and Nanoscale Technologies for the Biosciences, Montreux, Switzerland, November 14-16, 2006. Oral Presentation. 23. P. Neuzil, L. Novak and J. Pipper Miniaturized DNA/RNA Detection Systems Institute of Molecular Genetics, Prague, Czech Republic, November 14-16, 2006. Public Lecture.
25. S. Steinert, S. Hebbar, E. Lee, R. Hortsch and R. Kraut Characterization of Raft-derived Trafficking Pathways Followed by a Novel Peptidebased Sphingolipid Tracer International Conference on Neurochemistry, Antigua, West Indies, Caribbean, December 1, 2006. Poster Presentation. 26. Y. C. Toh, Y. M. Khong, S. Chang, V. D. Samper, D. W. Hutmacher and H. Yu Maintaining 3D Cellular Phenotypes in Microfluidic Channels University of Tokyo (UT) Symposium on Nanobio Integration, Tokyo, Japan, December 4-7, 2006. Poster Presentation.
28. L. Yu, A. J. Pang, B. Chen, F. E. H. Tay and C. Iliescu Adhesive Wafer-to-Wafer Bonding Using Contact Imprinting Smart Materials, Nano- and Micro-Smart Systems 2006, Adelaide, Australia, December 10-13, 2006. Poster Presentation.
30. C. Iliescu, G. Xu, F. E. H. Tay and P. L. Ong An Electromechanical Filter for Bioparticles Trapping Smart Materials, Nano- and Micro-Smart Systems 2006, Adelaide, Australia, December 10-13, 2006. Oral Presentation. 31. A. Avram, M. Avram, M. Volmer and C. Iliescu BioMEMS for the Determination of Rheological Properties of Biological Fluids Smart Materials, Nano- and Micro-Smart Systems 2006, Adelaide, Australia, December 10-13, 2006. Oral Presentation. 32. D. Lee, G. L. Xu, H. K. Tay, C. Yang and J. Y. Ying Microfluidic Device with Asymmetric Electrodes for the Delivery of Cells and Reagents Smart Materials, Nano- and Micro-Smart Systems 2006, Adelaide, Australia, December 10-13, 2006. Oral Presentation. 33. J. Wei, P. L. Ong, F. E. H. Tay and C. Iliescu A New Fabrication Method of Low Stress PECVD SiNx Layers for Biomedical Application Thin Films 2006, Singapore, December 11-15, 2006. Oral Presentation. 34. B. Chen, C. Iliescu, F. E. H. Tay and J. M. Miao Low Stress PECVD Amorphous Silicon for MEMS Applications Thin Films 2006, Singapore, December 11-15, 2006. Oral Presentation.
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Annual Report 2006
27. S. S. S. Ng, R. B. Han, H. L. Leo and H. Yu Perfusion with Excretory Function Promotes the Long-Term Functional Maintenance of Hepatocytes University of Tokyo (UT) Symposium on Nanobio Integration, Tokyo, Japan, December 4-7, 2006. Poster Presentation.
29. C. Iliescu, D. P. Poenar, K. J. Leck, M. Carp, A. J. Pang and F. C. Loe Novel Microfluidic Device for Cell Characterization by Impedance Spectroscopy Smart Materials, Nano- and Micro-Smart Systems 2006, Adelaide, Australia, December 10-13, 2006. Oral Presentation.
Institute of Bioengineering and Nanotechnology
24. G. L. Xu, J. Loh, C. Y. Zhang, D. Lee, R. Qi, T.M. Hsieh, P. Neuzil, N. Y. Kim and J. Y. Ying IBN MicroKit: A Safe and Rapid System for Infectious Disease Detection 11th International Conference on Emerging Infectious Diseases, Singapore, November 16, 2006. Oral Presentation.
Annual Report 2006 Institute of Bioengineering and Nanotechnology
50
35. A. J. Pang, B. Chen, J. Wei, F. E. H. Tay and C. Iliescu Characterization of Silicon Carbide Films by Plasma-Enhanced Chemical Vapor Deposition Thin Films 2006, Singapore, December 11-15, 2006. Poster Presentation.
40. S. T. Selvan, P. K. Patra, G. C. Papaefthymiou and J. Y. Ying Live Cell Imaging with Semiconductor and Magnetic Quantum Dots 233rd American Chemical Society National Meeting and Exposition, Chicago, Illinois, USA, March 25-29, 2007. Oral Presentation.
36. A. Lim, Y. S. Wang, S. Kumar and R. Kraut Neurodegenerative Endolysosomal Mutant Bchs Impairs Motoraxon Trafficking in Drosophila Keystone Symposia – Molecular Mechanisms of Neurodegeneration, Taos, New Mexico, January 16-21, 2007. Poster Presentation
41. Y. Y. Yang, Y. Wang and C. Y. Ke Cationic and Biodegradable Polymer Micelles for Efficient Gene Delivery and Effect of Core-Shell Structure 233rd American Chemical Society National Meeting and Exposition, Chicago, Illinois, USA, March 25-29, 2007. Oral Presentation.
37. G. Ho, C. Y. Zhang and L. Zhuo Non-Invasive Imaging of GFAP-GFP Expression in Neonatal Transgenic Mice as a Model for Studying Parkinsonism and Developmental Neurotoxicity BIOS 2007 - Photonics West 2007, San Jose, California, USA, January 20-23, 2007. Oral Presentation.
42. Y. G. Zheng, Z. C. Yang and J. Y. Ying Zn1-xCdxSe Alloyed Quantum Dots 233rd American Chemical Society National Meeting and Exposition, Chicago, Illinois, USA, March 25-29, 2007. Oral Presentation.
38. C. Ren, S. J. Gao, M. Kurisawa, J. E. Chung and J. Y. Ying Injectable Hyaluronic Acid Scaffolds for Cartilage Tissue Engineering Singapore-MIT Alliance Symposium, Singapore, January 23, 2007. Poster Presentation. 39. M. Khan, H. E. Shuen, P. Chan and Y. Y. Yang Novel Chitosan-based Non-Viral Vectors for Gene Delivery Australasian Polymer Symposium (APS), Tasmania, Australia, February 11-15, 2007. Oral Presentation.
43. Y. G. Zheng, S. J. Gao and J. Y. Ying Glutathione-Capped CdTe Quantum Dots: Synthesis and Applications in Biological Imaging 233rd Spring American Chemical Society National Meeting and Exposition, Chicago, Illinois, USA, March 25-29, 2007. Oral Presentation. 44. S. T. Selvan, T. Tan, D. K. Yi, S. Gao and J. Y. Ying Silica-Coated Semiconductor and Magnetic Quantum Dots for Bio-Labeling Applications RSC Conference on Nanoparticles: New Opportunities and Challenges for Colloid Scientists, Warwick, United Kingdom, March 2830, 2007. Oral Presentation.
Board Memberships and Professional Services
Jackie Y. Ying
Editorial Board, Journal of Porous Materials (June 1993 to present) Editorial Board, Journal of Electroceramics (June 1996 to August 2006) Editorial Board, Nanoparticle Science and Technology (April 1998 to present) Editorial Board, Journal of Metastable and Nanostructured Materials (February 2000 to present) Advisory Editor, Molecular and Supramolecular Science (July 2000 to present)
Advisory Board, National Research Council of Canada Steacie Institute for Molecular Sciences, Canada (November 2001 to present) Honorary Professor of Chemistry, Jilin University, China (August 2002 to present) Editorial Advisory Panel, Materials Today (October 2002 to present)
Chair of Governing Board, Singapore-University of Washington Alliance in Bioengineering, Singapore (September 2003 to March 2008) Co-opted Member, A*STAR Executive Committee (January 2005 to December 2006) Board of Governors, Raffles Girls’ Secondary School, Singapore (January 2005 to December 2007)
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Advisory Panel, Singapore Press Holdings’ Chinese Newspapers (January 2005 to December 2008) Editorial Advisory Board, Journal of Experimental Nanoscience (February 2005 to present) Adjunct Professor of Chemical Engineering, Massachusetts Institute of Technology (March 2005 to present) Advisory Board, Journal of Nanomaterials (July 2005 to present) Editorial Board, Biomedical Materials: Materials for Tissue Engineering and Regenerative Medicine (September 2005 to present)
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Scientific Advisory Board, Leibniz-Institut für Festkörper- und Werkstoffforschung Dresden, Germany (February 2001 to present)
Advisor in Life Sciences and Medicine, World Scientific Publishing Co (September 2003 to present)
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Advisory Board, Chemical Sciences Graduate School Finder, American Chemical Society (December 1992 to present)
Professor of Chemical and Biomolecular Engineering (Courtesy Appointment), National University of Singapore, Singapore (January 2003 to present)
International Advisory Board, Canadian Journal of Chemical Engineering (January 2006 to December 2007)
Blue-Ribbon Committee, “Grand Challenges for Engineering� (October 2006 to October 2007)
International Editorial Advisory Panel, Biomolecular Frontiers (January 2006 to present)
Adjunct Professor of Engineering and Science, Nanyang Technological University, Singapore (January 2007 to present)
Panel on Benchmarking the Research Competitiveness of the US in Chemical Engineering, National Research Council, Board of Chemical Sciences and Technology (February 2006 to November 2006)
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Executive Committee Member, A*STAR Biological Resource Centre (May 2006 to April 2007)
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National Medical Research Council Peer Review Committee, Singapore (2002 to present)
Honorary Professorship, Sichuan University, China (June 2006 to present)
A*STAR Biomedical Research Council Extramural Grant Proposals Local Review Panel, Singapore (2004 to present)
Selection Committee, 2006 National Technology Award (June 2006 to July 2006)
Andrew Wan
Biomedical Research Council Evaluation Panel, A*STAR Grand Challenge Search (July 2006)
Organizing Committee, Singapore National Academy of Science Young Scientist Award (January 2007 to September 2007)
Scientific Advisory Board, Molecular Frontiers (August 2006 to present) Asia Committee, Society of Nanoscience and Nanotechnology (September 2006 to present) Editorial Board, International Journal of Molecular Engineering (September 2006 to present)
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Shu Wang
Yi-Yan Yang Editorial Board, Biomedical Nanotechnology (June 2004 to present)
Hanry Yu
Vice-Chair of Scientific Advisory Board, SingaporeUniversity of Washington Alliance in Bioengineering (2003 to present) Scientific Advisory Board, CyGenics Ltd (Cordlife Pte Ltd, Singapore), Australia (2004 to present) Research Taskforce Workgroup, Yong Loo Lin School of Medicine, National University of Singapore (2004 to 2006) Executive Committee of Graduate Program in Bioengineering (GPBE), National University of Singapore Graduate School of Integrative Sciences and Engineering (2005 to present)
Steering Committee, Singapore Bio-Imaging Consortium (2005 to present) University Research Committee Evaluation Panel for Biomedical Engineering and Biomedical Sciences, National University of Singapore (November 2006-2008)
Pei Yong Chow Editorial Board, A*STAR Explosion Scientific Resource Panel (2006 to present) Editorial Board, Journal of Biological Engineering (2007) Associate Editor, Journal of Biological Engineering (2007 to 2009)
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Judge, Singapore Science and Engineering Fair 2007 (March 2007)
Zhilian Yue Editorial Board, Journal of Biological Engineering (2007)
Gideon Ho Judge, Singapore Science and Engineering Fair 2007 (March 2007)
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Chair of Graduate Committee, Computational and Systems Biology Program, Singapore-MIT Alliance (2005 to present)
Member of Tissue Engineering Program, National University of Singapore (2006 to present)
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Medical Faculty Research Committee, Yong Loo Lin School of Medicine, National University of Singapore (October 2001 to present)
Adjunct Scientist, National University Hospital (2006 to present)
Jeremy M. H. Loh Judge, Singapore Science and Engineering Fair 2007 (March 2007)
JĂŠrome Boulaire
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Judge, Singapore Science and Engineering Fair 2007 (March 2007)
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Awards
Marioara Avram, Andrei Avram, Ciprian Iliescu, Elena Manea and Corneliu Voitincu Best Paper Award, “Microfluidic Dynamic System for Biological Fluid Viscosity Measurements,” International Semiconductor Conference 2005 (CAS 2005, 28th edition), Romania, September 2006. Jeremy M. H. Loh, James T. M. Hsieh, Rosa Qi, Daniel Y. S. Lee, Chunyan Zhang and Jackie Y. Ying Honorary Mention Award (Industry Category), “Making Molecular Diagnosis and Bio-Sample Preparation a Breeze through LabVIEW-Inspired System Automation,” 2006 ASEAN Virtual Instrumentation Applications Contest, Singapore, December 2006.
Lingfan Jiang, Yu Han and Jackie Y. Ying Silver Award, “Helical Mesoporous Silica from Achiral Cationic Surfactant Template,” Singapore Science and Engineering Fair, Singapore, March 2007.
Yunsong Choo, Pemakorn Pitukmanorom and Jackie Y. Ying Bronze Award, “Cu2+ Ions Immobilized in Bisphosphonate-Cu3(PO4)2 Nanoparticles Can Adsorb Urea,” Singapore Science and Engineering Fair, Singapore, March 2007. Priscilla Wee, Yun Pei Koh, Fan Lee and Motoichi Kurisawa Merit Award, “Synthesis of Hyaluronic Acid-Tyramine Hydrogel and a Study of its Degradation and Protein Release,” Singapore Science and Engineering Fair, Singapore, March 2007. Jessica S. C. Yeo, Naiyan Chen and Hsiao-Hua Yu Merit Award, “Stability of Self-Assembled Monolayerbased Nucleic Acid Biosensor,” Singapore Science and Engineering Fair, Singapore, March 2007.
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Nhat Linh Vuong, Duo Wu and Motoichi Kurisawa Gold Award, “Synthesis of Hyaluronic Acid-Flavonoid Conjugates and Their Biomedical Applications,” Singapore Science and Engineering Fair, Singapore, March 2007.
Mark T. W. Lim, Gunter Maubach and Lang Zhuo Bronze Award, “Investigating the Effect of 3’ Untranslated Regions from GFAP Splice Variants on MRNA Stability Using a Reporter Construct,” Singapore Science and Engineering Fair, Singapore, March 2007.
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Yu Han National Science and Technology Young Scientist Award, Singapore National Academy of Science, Singapore, October 2006.
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Miniaturized microarray for drug testing applications
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IBN filed a total of 111 patents, including 28 primary patents, in FY2006. 1 US patent was granted over this period. Our research projects have attracted interest from many sectors, including multi-national companies, venture capitalists, and other research organizations.
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Industrial Capital
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Annual AnnualReport Report2006 2006
Annual Report 2006
Patents
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IBN researchers have filed 368 patent applications on their novel technologies since 2003
Patent Granted
Patent Applications Polymeric Salts and Polymeric Metal Complexes (Synthesis and Applications of Main Chain PolyImidazolium) Jackie Y. Ying, Yugen Zhang, Dingyu Hu and Pranab K. Patra PCT Patent Application filed April 2006 Heterogenized Catalysts for Ring-Closing Metathesis Jackie Y. Ying, Jaehong Lim and Su Seong Lee U.S. Provisional Patent Application filed April 2006
Stabilizing a Novel 3D Hepatocyte Monolayer Culture by a Hybrid Bioactive Substratum for Hepatocyte-based Applications Hanry Yu, Rongbin Han and Yanan Du U.S. Provisional Patent Application filed May 2006 A Novel Pressure-Driven Method for Enzyme Immobilization on Hydrophobic Mesoporous Silica Supports Jackie Y. Ying, Yu Han and Su Seong Lee China and Hong Kong Patent Applications filed June 2006
Thermally Responsive Reverse Micelles for Immobilization of Enzymes Yi Yan Yang, Hongwei Yu, Chi Bun Ching and Hong Chen Provisional U.S. Patent Application filed July 2006 A Fluorescent Sphingolipid Microdomainbinding Peptide for Tracking Sphingolipid Trafficking in Animal Cells Rachel S. Kraut, Steffen Steinert and Sarita Hebbar Provisional U.S. Patent Application filed July 2006 Customized N-Heterocyclic CarbenePalladacycle Precatalysts for PalladiumMediated Organic Transformations Jackie Y. Ying and Eric Assen B. Kantchev Provisional U.S. Patent Application filed July 2006 Ultrasonic Enhanced Microneedle Array for Transdermal Drug Delivery Ciprian Iliescu and Bangtao Chen Provisional U.S. Patent Application filed August 2006 Circulating Flow-Type Reactor Jackie Y. Ying, Yu Han, Su Seong Lee, Jaehong Lim and Siti Nurhanna Binte Riduan U.S. Patent Application filed August 2006
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A Mechanically Reversible Gel for 3-Dimensional Cell Culture and Tissue Engineering Shona Y. Pek, Andrew C. A. Wan and Jackie Y. Ying U.S. Provisional Patent Application filed May 2006
Multi-Functional Micelles (Core-Shell Nanoparticles) Self-Assembled from FolateConjugated Poly(N-isopropylacrylamideco-N,N-dimethylacrylamide-co-2aminoethylmethacrylate)-b-Poly(10-undecenoic acid) for Targeted Delivery of Anticancer Drugs Yi Yan Yang and Shao Qiong Liu PCT Patent Application filed July 2006
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Synthesis and Application of Stable High Oxidation State Ferrocene Derivatives Zhiqiang Gao, Fang Xie and Hong Xie U.S. Patent Application granted April 2006
Electronic Field Mattress – Sleep Monitoring Device for Children with Eczema Kwong Luck Tan, Francis Eng Hock Tay and Hugo Van Bever Singapore Patent Application filed July 2006
Integrated Optical System Pavel Neuzil, Juergen Pipper and Lucas Novak Provisional U.S. Patent Application filed August 2006 Development of Porous Polymeric Membranes/ Scaffolds for Biohybrid Organs Pei Yong Chow, Jackie Y. Ying, Jeremy Ming Hock Loh and Karl Maria Schumacher PCT Patent Application filed September 2006 Method of Using Baculovirus Vectors for Gene Delivery to Neurons Shu Wang and Ying Li Patent Applications filed September 2006 in Europe, France, United Kingdom, Germany, China, Japan, United States and Singapore
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Droplet-based Electrochemical Sensors Pavel Neuzil, Hsiao-hua Yu and Jackie Y. Ying Provisional U.S. Patent Application filed September 2006
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Fibrous Scaffolds by Hydroentanglement Jackie Y. Ying and Andrew C. A. Wan PCT, France, Germany, United Kingdom, United States and Singapore Patent Applications filed September 2006 Real-Time Conductimetric pH Response of Poly (3,4-ethylenedioxythiophene)s Jackie Y. Ying, Hsiao-hua Yu, Emril Mohamed Ali and Eric Assen B. Kantchev PCT Patent Application filed September 2006 Methods to Create Chemical Patterns Namyong Kim, Jackie Y. Ying, Hua Zhang, Yong Yeow Lee and Kwong Joo Leck PCT Patent Application filed November 2006
N-Heterocyclic Carbene Catalyzed Ketone and Imine Hydrosilylation and a Novel Chiral Induction Protocol Yugen Zhang and Jackie Y. Ying PCT Patent Application filed September 2006 Cell Adhesive Polyelectrolyte Materials for Use as Membrane and Coating Jackie Y. Ying, Andrew C. A. Wan and Karl Maria Schumacher PCT Patent Application filed October 2006 Stable High Oxidation State Diamine Metallocenes and Processes for their Preparation Zhiqiang Gao, Fang Xie and Hong Xie Europe Patent Application filed October 2006 PCT and Singapore Patent Applications filed October 2006 Gene Delivery to Promote Nerve Regeneration Shu Wang and Xu Wang Singapore Patent Application filed October 2006 Device and Method for Studying Cell Migration and Deformation Muthiah Manimaran, Francis Eng Hock Tay and Pei Lin Mao Singapore Patent Application filed October 2006 Novel Biodegradable Cationic Core-Shell Nanoparticles for Codelivery of Drug and DNA Yi Yan Yang, Darren Cherng-wen Tan, Jackie Y. Ying and Yong Wang China, Indonesia and Singapore Patent Applications filed October 2006 Method and Device for Detection of Nucleic Acids and/or Polypeptides Zhiqiang Gao, Hong Xie and Yuan Hong Yu PCT and Singapore Patent Applications filed October 2006
Method of Using Baculovirus Vectors for Gene Delivery to Neurons Shu Wang and Ying Li Japan Patent Application filed October 2006 Europe Patent Application filed November 2006 Drug-Loaded Contact Lenses for Ophthalmic Drug Delivery Edwin Pei Yong Chow and Yi Yan Yang India Patent Application filed October 2006 China Patent Application filed December 2006
Ethylenedioxythiophene Intercalators Hsiao-hua Yu, Jackie Y. Ying, Natalia Chendrawati Tansil and Eric Assen B. Kantchev Provisional U.S. Patent Application filed November 2006 Self-Lubricating Contact Lenses: Wetting Agent Delivery via Nanostructured Hyaluronic Acid Primed Contact Lens for Dry Eye Relief Edwin Pei Yong Chow and Jackie Y. Ying Provisional U.S. Patent Application filed November 2006 Nanoparticle and Methods Thereof Zhiqiang Gao PCT Patent Application filed November 2006 Electrochemical Method of Detecting an Analyte Zhiqiang Gao PCT Patent Application filed November 2006
Novel DNA Threading Intercalator Zhiqiang Gao and Fang Xie Singapore Patent Application filed November 2006
Three-Dimensional Reconstituted Extracellular Matrices as Scaffolds for Tissue Engineering Jackie Y. Ying, Kwong Joo Leck and Andrew C. A. Wan PCT Patent Application filed December 2006
Method of Producing a Pattern of Discriminative Wettability Namyong Kim, Jackie Y. Ying, Hua Zhang, Yong Yeow Lee and Kwong Joo Leck PCT Patent Application filed November 2006
Phospholipid-based Complexes as Efficient and Non-Toxic Delivery Systems of Nucleic Acids Gillaume Tresset and Jerome Boulaire Provisional U.S. Patent Application filed December 2006 Novel Temperature- and pH-Sensitive Copolymers Kumaresh Soppimath and Yi Yan Yang Indonesia Patent Application filed December 2006 Singapore Patent Application filed December 2006
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Annual Report 2006
Implantable Natural Bone Scaffolds Using Processed Animal Bone Yuri Shona Pek, Pei Lin Mao, Yuan Hong Yu and Lihong Liu PCT and Singapore Patent Applications filed November 2006
Apparatus for Processing a Sample in a Liquid Droplet and Method of Using the Same Kwong Joo Leck, Namyong Kim, Jackie Y. Ying, Li Li and Yong Yeow Lee PCT Patent Application filed November 2006
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Reversible Suppression and Restoration of Protein and Oligomeric (-)-Epigallocatechin-3-Ogallate (OEGCG) Activities Upon Complexation and Dissociation of Micellar Nanocomplex for Delivery of Drug, Protein and Gene Lang Zhuo, Joo Eun Chung, Motoichi Kurisawa and Yi Yan Yang U.S. Patent Application filed October 2006
N-Heterocyclic Carbene (NHC) Catalyzed Synthesis of Isoxazolidin-5-ones and One-Pot Synthesis of Ă&#x;-Amino Acid Esters Yugen Zhang, Jackie Y. Ying, Jayasree Seayad and Pranab K. Patra Provisional U.S. Patent Application filed March 2007 N-Heterocyclic Carbene (NHC) Catalyzed Acylation of Nitroso Compounds: Synthesis of Hydroxamic Acids Yugen Zhang, Jackie Y. Ying, Jayasree Seayad, Fong Tian Wong and Pranab K. Patra Provisional U.S. Patent Application filed March 2007
Kidney tubules generated in hydrogel droplet for implantation
Device for Small Scaled Encapsulation of Animal Cells Hanry Yu, Jing Zhang and Hai Ting Ho Singapore Patent Application filed December 2006
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Economical Real-Time PCR Pavel Neuzil, Tseng-Ming Hsieh and Juergen Pipper PCT Patent Application filed February 2007
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Mesoporous Polymer Colloids and Their Application as Supported Asymmetric Organocatalysts Yugen Zhang, Jackie Y. Ying and Pranab K. Patra PCT Patent Application filed March 2007 A Fluorescent BODIPY Coupled Far-Red Emitting Lactosyl Ceraminde Analog Exhibits Trafficking Properties in Insect Neurons that Monitor Intracellular Cholesterol Conditions Rachel Kraut, Ralf Hortsch and Nandanan Erathodiyil Provisional U.S. Patent Application filed March 2007
Catalyst Immobilization on Siliceous Mesocellular Foam via Click Chemistry Jackie Y. Ying, Jaehong Lim, Su Seong Lee and Siti Nurhanna Provisional U.S. Patent Application filed March 2007 Synthesis and Catalytic Applications of Supported Palladium Nanoclusters in Coupling and Hydrogenation Reactions Jackie Y. Ying and Nandanan Erathodiyil PCT Patent Application filed March 2007 Use of TMEM18 Protein Encoding Nucleic Acids to Regulate the Tropism of Neural Stem and Precursor Cells for Glioma Cells Shu Wang and Jaana Jurvansuu Provisional U.S. Patent Application filed March 2007
Commercialization Efforts
Research Collaborations In FY2006, IBN established 10 new collaborations with academic institutions, including local and international universities as well as research institutes. IBN currently has 43 collaborations with the Bioprocessing Technology Institute (Singapore), Biomedical Imaging Laboratory (Singapore), Centre for Molecular Medicine (Singapore), Cornell University (USA), Defense Science Organisation (Singapore), Defense Medical and Environmental Research Institute (Singapore), Drexel University (USA), DSO
IBN has also established a new satellite laboratory to be run by Prof. James Heath of California Institute of Technology (Caltech). The collaborative project between IBN and Caltech involves the development of highaffinity capture agents for in vitro diagnosis of diseases. In addition, the Institute fostered 6 new collaborations with local and international clinical groups, as well as 2 new collaborations with industry partners in FY2006. The Institute currently has 8 collaborations with the National University Hospital (Singapore), National Cancer Centre (Singapore), National Neuroscience Institute (Singapore), Singapore General Hospital, Tohoku University School of Medicine (Japan), and University Hospital Rostock (Germany). IBN’s industrial partners are Agilent (Australia) and Genentech (USA). IBN also obtained external funding/co-funding for key projects from various sources, including A*STAR Biomedical Research Council, A*STAR Science and Engineering Research Council, Defense Science Organisation, ETPL (Commercialization of Technology (COT) Grant), as well as Singapore Bioimaging Consortium.
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IBN’s novel, nanostructured drug-eluting contact lens technology has also received a lot of interest from multi-national contact lens manufacturers and visioncare providers. It is a polymeric lens system formed using a bicontinuous microemulsion technique. By adjusting the components of the lens mixture, the width of the nano-channels within the system can be varied for different drug release profiles in various ocular applications. IBN has signed a licensing deal with one of the world’s largest contact lens manufacturers to develop novel applications based on this platform technology.
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Micro-Kit Pte Ltd, a spin-off company set up to commercialize IBN’s Lab-on-Chip, Micro RT-PCR, and Biosensor technologies, is currently being incubated at IBN. Scientists at the Institute have developed novel, integrated biochips, which have great potential to be used in clinical, point-of-care applications and high-throughput screening. These devices have the competitive advantage of offering simultaneous sample preparation and detection of RNA from tissues, as well as body fluids like saliva or blood. The Micro-Kit team has developed a series of prototypes for a fully automated diagnostics system that will detect the avian flu virus in a one-step processing involving RNA isolation and micro RT-PCR. The Kit is currently undergoing clinical trials at the National University Hospital.
National Laboratories (Singapore), Fudan University (China), Genome Institute of Singapore, Ian Wark Research Institute (Australia), Institute of Chemical and Engineering Science (Singapore), Institute of Microelectronics (Singapore), Institute of Molecular and Cell Biology (Singapore), Johns Hopkins University (USA), Massachusetts Institute of Technology (USA), National Institute of Education (Singapore), Nanyang Technological University (Singapore), National University of Singapore, Singapore Institute of Manufacturing Technology, Singapore Polytechnic, National Energy Technology Laboratory (Department of Energy, USA), State University of New York (Buffalo, USA), Tohoku University (Japan), University of Calgary (Canada), University Hospital Rostock (Germany), and Villanova University (USA).
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Drug-loaded contact lenses for controlled delivery of therapeutics to the eye
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Since 2003, IBN has received more than 6,700 applications for research positions and its staff strength has grown from 25 to over 180, including 28 graduate students.
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IBN has successfully recruited researchers from top institutions worldwide and its multinational staff originates from Australia, Bulgaria, Canada, China, France, Germany, Hong Kong, India, Indonesia, Japan, Korea, Malaysia, Netherlands, Romania, Singapore, Sweden, Taiwan, Thailand, United Kingdom, United States, and Vietnam. Their expertise lies in diverse disciplines, including biomedical, biological, chemical, electrical and mechanical engineering, biology, chemistry, physics, materials science, computer science, pharmacy and medicine.
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Youth Outreach
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Nano-bio kit to introduce biological fuel cell applications in classrooms
The Institute also continued its partnership with the Singapore Science Center (SSC). IBN researchers presented an overview of IBN’s research and YRP to over 220 students and teachers from various schools in two Meet-the-Scientist sessions organized by the SSC in November 2006 and February 2007. In September 2006, IBN participated in a public science fair, Xperiment 06, which was held over three days at Marina Square.
A significant number of secondary school, junior college and polytechnic students and teachers as well as undergraduates participated in research attachments at IBN in FY2006. The full-time and part-time attachments lasted for a period of 1 month to a year. Many of these students and teachers became interested in research internships after
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In FY2006, IBN reached out to more than 6,400 students and teachers from various schools through 35 organized activities. Among these were 13 Open Houses and lab tours for 1,069 students and teachers from 59 schools. IBN scientists also delivered 18 seminars/talks to over 4,700 students at various secondary schools, junior colleges, polytechnics and universities. The participating schools included Anglo-Chinese School (Independent), Dunman High School, Hwa Chong Institution (High School), Nanyang Girls’ High School, Raffles Institution, Anderson Junior College, Hwa Chong Institution (College), National Junior College, Raffles Junior College, Victoria Junior College, Nanyang Polytechnic, Ngee Ann Polytechnic, Republic Polytechnic, Singapore Polytechnic, Temasek Polytechnic, Nanyang Technological University and National University of Singapore.
On March 9, 2007, IBN launched its latest YRP initiative, the Nano-Bio Kits, to over 440 students, teachers, companies and media representatives at an IBN Open House for Schools where Minister of State for Trade and Industry, Mr. S. Iswaran was the Guest-of-Honor. These Nano-Bio Kits are educational kits to help teachers introduce practical applications of bioengineering and nanotechnology to students. They contain material for teachers and students to conduct a series of experiments that demonstrate various scientific concepts and techniques. The first three kits in the series feature Dielectrophoresis Chips, Thermo-Responsive Hydrogels and Biological Fuel Cells. The Kits were tested in 3 phases by 12 schools. Pre-launch sales were encouraging with over 100 Kits sold to 10 different schools and institutions. To-date, 141 Kits have been sold. IBN researchers have conducted courses on the Kits to more than 400 students from Hwa Chong Institution (High School), National Junior College and Raffles Institution. Three more schools, Anderson Junior College, Anglo-Chinese School (Independent) and United World College have also incorporated the Kits in their syllabus. The Nano-Bio Kits have also attracted international interest and will be featured in an exhibition organized by the Miraikan Museum of Science in Tokyo, Japan in June 2007, as well as at the Museum of Modern Art in New York City, USA in late 2007. In FY2007, IBN will line up a series of activities for teachers to promote the use of the Kits in the classroom. To help IBN kick-start the NanoBio Kits’ marketing and production efforts, ETPL has provided IBN with S$150,000 in COT funding. The Institute is currently looking for industrial partners to target the overseas markets.
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IBN continued to actively promote scientific research among the young through its Youth Research Program (YRP) in FY2006. Set up in October 2003, YRP aims to expose more young people and their educators to cutting-edge research in bioengineering and nanotechnology through activities such as Open Houses, workshops, career fairs, seminars/talks, visits and research attachments for both students and teachers from the primary to tertiary levels. By the end of FY2006, over 13,600 students and teachers from 171 schools and tertiary institutions, including overseas universities, have participated in the YRP.
participating in IBN’s YRP activities such as Open Houses, career talks and workshops. The students and teachers either applied to IBN directly, or through their respective schools, A*STAR or the Ministry of Education. In FY2006, a total of 193 students and 9 teachers participated in full-time research attachments at IBN for at least one month. The YRP calendar for 2006 capped off with Young Researchers’ Nite on December 20, 2006. The annual event showcased the outstanding work done by the attachment students and teachers at IBN in the past calendar year, and was also a platform for YRP participants and mentors to share their experiences. During the event, IBN recognized participants who showed great potential for research, as well as the mentors’ efforts in nurturing the research interests of
their students. 5 Promising Young Researcher awards were given to Shireen Tan Yan Ling (Raffles Junior College), Eddie Tan Han Pin (Temasek Polytechnic), Deon Chiew Sze Tat (Ngee Ann Polytecnic), Zhang Yi (Nanyang Technological University) and Steffen Steinert (Technische Universität Dresden, Germany) for their outstanding performance during their research attachment at IBN. 3 IBN researchers, Dr Gideon Ho, Dr Rachel Kraut and Dr Jeremy Loh, received the Outstanding Mentor Awards for being excellent mentors to YRP students. IBN Research Scientist Dr. Edwin Chow received a Special Recognition Award from YRP for his significant contribution to the program since its inception. For more information on the YRP and its calendar of activities, log onto yrp.a-star.edu.sg.
YRP Calendar of Events Month
Event
No. of participants
April 10
Career Talk at Hwa Chong Institution
150
April 25
Career Talk at Republic Polytechnic
170
May 3
Talk at Raffles Junior College Science Symposium 2006
200
May 17
Career Talk at Temasek Polytechnic
140
June 2
Open House for South Zone Schools
270
June 29
Visit by A*STAR Scholars
32
July 14
Visit by International Physics Olympiad Students
45
July 20
Visit by Students from Hong Kong Schools
40
July 21
East Zone Science Carnival at Victoria Junior College
300
July 26
Career Talk at Nanyang Polytechnic
90
August 2
Talk at Ngee Ann Polytechnic Biotechnology Fair 2006
350
August 14
Career Talk at Dunman High School
200
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April 2006
May 2006
June 2006
July 2006
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August 2006
Month
No. of participants
August 15
Nano-Bio Kit Course at Hwa Chong Institution
25
August 23
Nano-Bio Kit Course at Raffles Institution
400
September 1-3
X-periment! at Marina Square Atrium
300
September 5
Open House for Science Teachers from North Zone Schools
72
September 15
Nano-Bio Kit Course at Raffles Institution
400
October 2
Visit by International Summit of Young Scientists and Viswajyothi Public School (India)
42
October 6
Visit by Pat’s Schoolhouse
29
October 14
Open House at National Junior College
200
October 18
Career Talk at Singapore Polytechnic
180
October 27
Talk at Nanyang Girl’s High School
340
September 2006
October 2006
69
November 2006 Meet the Scientist Session at Singapore Science Centre
100
November 20
Visit by Secondary and Pre-University Science Teachers
20
November 22
Career Talk at Singapore Polytechnic
80
November 23
Visit by Professors from Australian Universities
20
November 30
Visit by University of Twente, The Netherlands
30
Young Researchers’ Nite 2006
100
Visit by Principals from Vietnamese Schools
9
Meet the Scientist Session at the Biopolis
121
March 2
Career Talk at Anglo-Chinese School (Independent) Symposium and Open House
1000
March 9
Open House for Schools and Launch of the Nano-Bio Kits
440
March 12
Visit by Air War College, USA
20
March 21
Career Talk at Anderson Junior College
850
March 29
Talk at National University of Singapore, Department of Chemistry and Biomolecular Engineering
7
December 2006
January 2007 January 24 February 2007 Febuary 28 March 2007
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November 10
December 20
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Event
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Artificial scaffold to heal bone defects
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Research Expenditure
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Annual Annual Report Report 20062006
Income and Expenditure Statement for the year ended 31 March
2007 (S$000)
2006 (S$000)
Annual Report 2006
Operating Income 3 41 Staff Cost 12,241 9,696 Depreciation 12,742 10,512 R&D Expenditures 7,540 6,351 Staff Recruitment & Development 342 277 Computers & IT Cost 554 577 Rental 3,847 3,849 Other Facilities Cost 6,374 5,614 Travel & Entertainment Cost 31 16 Boards, Experts and SAB 429 332 Professional Fees 25 102 Publicity and Corporate Events 202 104 Other General Admin Expenses 1,322 1,359 Financial Charges 6 11
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Total Operating Expenses 45,655 38,800 Deficit before Grants (45,652) (38,759) Financed by:- Operating Grants 32,819 28,247 Deferred Capital Grants 12,836 10,512
45,655
38,759
Balance Sheet as at 31 March
2006 (S$000)
ASSETS Current Assets Cash & Cash Equivalents 12,086 13,575 Receivables 84 106 Prepayment & Deposits 202 584 12,372 14,265 Non-Current Assets Plant & Equipment 61,669 63,279 TOTAL ASSETS 74,041 77,544 LIABILITIES Current Liabilities Payables 3,349 2,623 Accruals 3,224 6,390 Grants received in advance 5,638 5,122
TOTAL LIABILITIES
74,038
77,544
NET ASSETS 3 0 Represented by:- Accumulated Surplus 3 0
73
Annual Report 2006
12,211 14,135 Non-Current Liabilities Provision for Gratuity 158 130 Deferred Capital Grants 61,669 63,279 61,827 63,409
Institute of Bioengineering and Nanotechnology
2007 (S$000)
Notes
Notes
Design and production by MINT EDITIONS (Singapore) Pte Ltd
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