VIB-VUB CENTER FOR STRUCTURAL BIOLOGY
NANOBODIES FOR BIOTECHNOLOGY AND HEALTH
At the VIB-VUB Center for Structural Biology, we study the structure and dynamics of macromolecular complexes in health and disease to explain their mode of action. We integrate our structural biology work with genetic and cellular studies, aiming to bridge molecular and cellular resolution. We excel in translating our discoveries into biotechnological and medical applications.
EXPERTISE
Bridging molecular and cellular resolution
We envision a structural biology that is increasingly closer to the cellular context, working on in situ or ex vivo samples, with minimal manipulation and as close as possible to the physiological processes under study. We aspire a further integration of time as an integral dimension of the structural biology principles we study. We envision a structural biology that transcends the explanatory power of the technique, into an exploratory instrument that leads to the discovery of novel biological pathways.
We answer key questions on biological systems, primarily located in the field of protein signaling cascades and host-pathogen interaction. Atomic level structural and biophysical insights are challenged and validated in their biological context through prediction and in vivo and in vitro experimentation, generating integrated models of the mode of action and regulation of the molecular processes and pathways involved.
CONTACT
Structural Biology Brussels
Vrije Universiteit Brussel
Pleinlaan 2 E4 1050 Brussels
Jan Steyaert
jan.steyaert@vub.be
Han Remaut han.remaut@vub.be
CREDENTIALS
The prime example is the development of our Nanobody® technology, which gave rise to established spin-off companies. The center’s expertise in nanopore technology has also led to a collaboration between CSB and Oxford Nanopore Technologies leading to the development of a new key element of state-of-the art sequencing tools.
WWW.CSB.SITES.VIB.BE/EN
PATENTS
We have a remarkable track record in turning excellent fundamental research into value for society. Since 2010, our center filed more than 20 patent applications in 9 different application areas.
