Thursday, January 17, 2013

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Thursday, January 17, 2013

Volume 106, Issue 58

Western researchers discover ALS mutation Iain Boekhofff Gazette Staff Researchers at Western University have discovered a new genetic mutation for amyotrophic lateral sclerosis, generating new hope for treatment of the deadly disease. Michael Strong, dean of the Schulich School of Medicine and Dentistry and scientist with Western’s Robarts Research Institute, was the leader of a team of researchers who discovered mutations within a specific gene are present in virtually all cases of ALS. When the researchers looked at both familial and sporadic forms of the disease, they found abnormal inclusions of the protein that arises from this gene. ALS, commonly referred to as Lou Gehrig’s disease, is a progressive and fatal disease that affects the motor neurons connecting the brain to the muscles throughout the body. ALS symptoms include muscle weakness in the arms and legs, slurred speech, twitching and cramping of the muscles and eventually paralysis. According to the Robarts Research website, approximately 80 per cent of patients die within two to five years of diagnosis, and between 1,500 to 2,000 people in Canada have ALS.

“We’ve been working for quite a period of time in trying to understand the basis of Lou Gehrig’s disease,” Strong said. “When we look under a microscope at the cells that are involved, in a number of cells we see these accumulations of proteins that shouldn’t be there. They can look like rock-or snake-like structures within the cell, but they shouldn’t be there.” “They’re normal under most circumstances but aggregating is not a good thing. And it turns out one of these rocks is due to an alteration in what we call a stability messenger RNA.” According to Strong, RNA is the link between genes and the proteins those genes produce. He also explained every gene will make thousands of RNA and every RNA will make thousands of proteins. “What we found was that the RNA for one of the components of the proteins that we were seeing deposited in the cells was unstable and was less than what you would expect to see in that cell,” he said. “We showed that this protein, RGNAF, actually interacted with the RNA that we were interested in. It only interacted in the ALS cases and when it did so it destabilized.” “We then went on to show that if we looked across a range of ALS

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cases, virtually every ALS case we looked in we could find that this new protein was deposited within the cells where it shouldn’t be,” he continued. Strong explained the next step was to examine how these proteins worked. He also noted this experiment was one of a kind and is not something that would be taught in

science classes. “This was an experiment you’d have to be nuts to do because most genetic studies the way that they are done nowadays is that massive groups get together they contribute thousands of DNA samples and you go looking,” Strong said. “This wasn’t that. We found the protein first, we showed that it

was abnormal, we showed that it was in the ALS cases and we looked in those cases where we found the protein being deposited and asked, ‘can we find a genetic abnormality?’” Further research based on this discovery could lead to new targeted therapies to help treat Lou Gehrig’s disease.

U of T club invites students to “sexy social” Alex Carmona News Editor

University students looking for some erotic excitement may want to consider heading to Toronto next Monday for the University of Toronto Sexual Education Centre’s upcoming ‘Sexy Social’. The event, aimed to kick off SEC’s annual Sexual Awareness Week, will be hosted at the Oasis Aqua Lounge, a water-themed sex club where only the hot tub and pool are off

limits for those looking to get down and dirty. Some corners of the Internet are billing the event as an orgy, decrying it as perverse or risky. However, Kayla Wright, executive director for the SEC, stressed the event will be more of a sex-positive social gathering, rather than a straight-up sex scene. “Basically, it’s a social that just so happens to take place at a sex club. We felt that it gives people the option, if they want, to go have sex

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in a clean, safe, positive environment,” she said. “Or to just hang out and meet people and hang out in a hot tub, which is totally why I’m going to be there.” The club typically has fairly stringent entrance policies, only allowing single men in one night a week and charging a whopping $80 per couple for regular entry. On Monday, however, the SEC will be taking over the entirety of the space and opening it up to any and

all Canadian university students aged 19+ for just five dollars. Wright said the group has been flooded with positive feedback, lauding them for their progressive stance on sex education. “To whoever is planning this week: I just want to send a virtual props your way. Hosting an event at a sex club is probably the best idea I have ever heard from campus group doing work around sexuality,” one member of the SEC Facebook group wrote. “But

it’s wonderful and clearly a lot of people appreciate that you’ve made this investment in promoting sexual awareness and also non-normative sexuality. It’s really a beautiful thing to see, especially from a campus like U of T.” Others, however, are more skeptical about the appropriateness of the event. One commenter raised concerns about the possibility of rape and STI transmission at the >> see Social pg.3

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