Thomas Jefferson University India Center Update

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JNMC Women’s and Children’s Health Research Unit A Primary Collaboration with Thomas Jefferson University and the Jefferson India Center

A BRIEF REPORT November 1, 2022 – June 15, 2023

HOME OF SIDNEY KIMMEL MEDICAL COLLEGE


A MESSAGE FROM THE DIRECTOR

RESEARCH Protocols Completed

Dear Colleague, We are pleased to share this inaugural update outlining the important events that have transpired as a result of our collaboration between KLE and Thomas Jefferson University. While this communication reviews some of the seminal activities jointly conducted over the past 6 months, we plan to update you more frequently during the coming year. The India Center is extremely proud of supporting more than 30 research grants as well as bilateral student and faculty exchanges. We are also committed to the joint development of new technology that holds significant promise for global application. Both Ravi Bhooplapur and I share in the vision of Chancellor Prabhakar Kore for the expanded collaboration of research conducted at KLE University. For more than 22 years, we have been proactive partners providing joint strategic planning that has resulted in worldwide recognition for KLE, and their designation as a nodal research site by the World Health Organization.

1. “Prevention of Maternal and Neonatal Death/Infections With a Single Oral Dose of Azithromycin in Women in Labor (in Low- and Middle-income Countries): a Randomized Controlled Trial” funded by the Global Network for Women’s and Children’s Health Research of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, USA (May 2019 to February 2023) (# enrolments completed: 5,635) Global Sample Size: 29,278 2. Limiting Adverse Birth Outcomes in Resource -Limited Settings – The LABOR Study” in collaboration with University of North Carolina at Chapel Hill, USA and funding by Bill & Melinda Gates Foundation, USA (January 2020 to October 2022) (# enrolments completed: 4,017) Global Sample Size: 12,000 3. “Implementing the WHO Labour Care Guide to reduce the use of Caesarean section in four hospitals in India: a pragmatic, stepped wedge, cluster randomized pilot trial” in collaboration with Burnet Institute, Australia; Institute for Clinical Effectiveness and Health Policy (IECS), Buenos Aires – Argentina; and the World Health Organization with funding from Bill & Melinda Gates Foundation, USA (November 2020 – October 2023) (# enrolments as on July 2022: 27,400) (Sample Size: 23,000)

We have just received the good news that our partnership has again been recognized by the National Institutes of Health (NIH) allowing us to continue our important work in maternal child health research for the next 7 years.

New Protocols Initiated

Below is a condensed listing of major achievements that we can all take pride in – many of the results having been published in in prestigious journals such as the New England Journal of medicine and the Lancet.

4. Single oral dose of azithromycin 2 gm to prevent maternal peripartum infection and newborn sepsis in laboring women (A-PLUS Trial): Repurposing azithromycin as a neuro-protector; a neurodevelopmental follow-up secondary study in collaboration with Thomas Jefferson University, Philadelphia, PA, USA and University of Alabama, Birmingham, USA with funding from Thrasher Research Fund, USA (November 2022-March 2023) (# enrolments as on June 2023: 38) (Sample Size: 70)

Ravi and I, along with Chancellor Kore, recognize the importance of leveraging grant funding. We are now calling upon you to consider making an annual tax deductible contribution to the India Center, knowing that 100% of all monies will be utilized to expand the important academic and scientific collaborations that presently exist between Jefferson and India. Best wishes, Richard Derman, MD Professor, Obstetrics and Gynecology Associate Provost, Global Health

Director, Global Health Research

5. “A Cluster Randomized Clinical Trial of Umbilical Cord Milking versus Early Cord Clamping on Short and Long-term Outcomes in Neonates Who are Non-Vigorous at Birth” in collaboration with Nemours Children’s Hospital and Thomas Jefferson University with funding from Eunice Kennedy Shriver National Institute of Child Health and Human Development, USA (Recruitment started November 1, 2022 and Enrolled: 589) (Sample size 3,442) 6. “Augmented Infant Resuscitator (AIR)” in collaboration with Mbarara University of Science and Technology, Uganda and Massachusetts General Hospital, Harvard University, Boston with funding from Grand Challenges Canada (November 2022 – November 2024) (Recruitment started March 6, 2023; Enrolled: 104 Participants) 7. “RAPIDIRON-Kids Study” in collaboration with Thomas Jefferson University, Philadelphia, PA, USA and funding by Children’s Investment Fund Foundation (CIFF), UK (February 2022 -February 2026) (Recruitment started November 2, 2022; Enrolled: 538 Participants) 8. “Neuroimaging sub study of IV Iron RAPID IRON trial” in collaboration with Collaboration with Thomas Jefferson University, Nemours Children’s Hospital, Philadelphia, University of Wisconsin and University of Minnesota and funding from Bill & Melinda Gates Foundation, USA (Recruitment started February 20, 2023; Enrolled: 184 Participants)

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ACTIVITY 9. “Validation of a Survey Instrument for Screening of Pre-Pregnant Women The PREPSA SCALE” in collaboration with Thomas Jefferson University and funding from Global Network for Women’s and Children’s Health Research of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, USA (December 2022 – December 2023) (Recruitment started April 17, 2023; Enrolled: 503 Participants) 10. “Prevention of Iron Deficiency Anemia Post-delivery (PRIORITY Trial) A Randomized Controlled Trial of the Global Network for Women’s and Children’s Health Research” in collaboration with Thomas Jefferson University, Philadelphia, PA, USA and funding by Global Network for Women’s and Children’s Health Research of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, USA, Bill & Melinda Gates Foundation, USA and Foundation for the National Institutes of Health, USA (November 2022 – November 2025) (Recruitment started May 29, 2023 at GH Bailhongal Enrolled: 06) (Sample Size 600 Participants)

Upcoming Protocols 1. Accelerating Innovation for Mothers (AIM)-Gender: Understand and address barriers to pregnant women’s participation in clinical trials in collaboration with The University of Melbourne, Australia and Funding from Concept Foundation, Geneva Switzerland 2. Implementation research on postpartum IV iron in Global Network sites: A Prevention of Iron Deficiency Anemia Post-delivery (PRIORITY) sub-study Collaboration with Thomas Jefferson University, USA Funding from Bill & Melinda Gates Foundation, USA 3. Pharmacokinetics and Pharmacodynamics of Antenatal CorticoSteroids when given to women at risk of Late Preterm Birth - A Sub-Study of the WHO ACTION-III TRIAL with funding from World Health Organization, Geneva, Switzerland

Participated in Steering Committee/Investigators Meetings 1. Steering Committee meeting of the NICHD Global Network for Women’s and Children’s Health Research on January 22-25, 2023 at Fort Lauderdale, USA Attendees: (Dr Shivaprasad S Goudar, Dr Manjunath Somannavar, Dr M C Metgud, Dr Umesh Charantimath, Dr Avinash Kavi) PI, Dr. Richard Derman, Thomas Jefferson University 2. WHO ACTION-III Investigators Meeting at WHO, Geneva Switzerland February 23-24, 2023 Attendees: (Dr Shivaprasad S Goudar, Dr S M Dhaded and Dr Yeshita Pujar) 3. Steering Committee meeting of the NICHD Global Network for Women’s and Children’s Health Research at Washington DC, USA January 22-25, 2023 Attendees: (Dr Prabhakar Kore, Dr Shivaprasad S Goudar, Dr Manjunath Somannavar, Dr M C Metgud, and Dr Avinash Kavi) PI, Dr. Richard Derman, Thomas Jefferson University

Monitoring Visits by Study Sponsors 1. Dr Ayesha DeCosta and Ms Nicole Minckas WHO Geneva visit to J N Medical College Belagavi and Karnataka Institute of Medical Sciences, Hubli on February 6-7, 2023 for monitoring the implementation of the WHO ACTION –III Trial 2. Dr Doris Chou HRP Division of WHO visit to J N Medical College, Belagavi, Gadag Institute of Medical Sciences, Gadag, J J M Medical College, Davanagere, Raichur Institute of Medical Sciences, Raichur and SCB Medical College, Cuttack for monitoring the implementation of the WHO STEPMag Trial from March 19-25, 2023 3. Visit of Delegation from Children’s Investment Fund Foundation UK India Country Office, New Delhi on April 26-27, 2023 for monitoring the implementation RAPIDIRON Trial.

Dissemination Activities 1. Dr Sunil Vernekar participated in Global Forum for Bioethics in Research meeting on “Ethics of Artificial intelligence in Global Health Research” organized by WHO and sponsored by NIH USA, Welcome Trust UK, Medical Research Council UK and South African Medical Research Council November 29-30, 2022 2. Participated in 65th All India Congress of Obstetrics & Gynecology AICOG 2023 Kolkata on Saturday, January 7, 2023 a. Dr Mrutyunjaya Bellad spoke on “Advent of Room Temperature Stable Carbetocin for Prevention of Postpartum Hemorrhage” b. Dr Shivaprasad Goudar presented “Interventions for Improving Maternal and Newborn Health Outcomes” highlighting results of JNMC Women’s and Children’s Health Research Unit Research Unit projects

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PUBLICATIONS c. Dr Yeshita Pujar was a Panelist on Postpartum Hemorrhage moderated by Dr Priti Kumar, Chair of Safe Motherhood Committee of FOGSI 3. Participated in 22nd Annual SNEHA-MRC International Workshop Developmental Origins of Health and Disease (DOHaD) organized by Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth Deemed University, Pune February 4-5, 2023 Attendees: (Dr Shivaprasad S Goudar, Dr Manjunath Somannavar, Dr Yogesh Kumar S) 4. Participated in 34th Annual UP Conference of Obstetrics and Gynecology March 17-19, 2023 organized by UPCON 23 and FOGSI Attendees: (Dr Shivaprasad S Goudar, Dr M B Bellad) 5. JNMC Women’s and Children’s Health Research Unit, Belagavi conducted 3rd International Conference on Maternal, Newborn and Child Health Translating Research Evidence to Practice Belagavi, Karnataka, India November 11-13, 2022

13 Countries participated

30 Resource persons

Under Process BJOG Supplement: Improving Maternal, Newborn and Child Health Outcomes in Low Resource Settings: Translating Research Evidence to Practice Supplement published to mark the 3rd International Conference on Maternal, Newborn and Child Health Research organized by Women’s and Children’s Health Research Unit, Jawaharlal Nehru Medical College, KLE Academy of Higher Education and Research, Belagavi, India on 11 to 13 November, 2022. 1. Fernandes M, Krebs NF, Westcott J, Tshefu A, Lokangaka A, Bauserman M, Garcés AL, Figueroa L, Saleem S, Aziz SA, Goldenberg RL, Goudar SS, Dhaded SM, Derman RJ, Kemp JF, Koso-Thomas M, Sridhar A, M McClure E, Hambidge KM; Women First Preconception Nutrition Trial Study Group. Neurodevelopment, vision and auditory outcomes at age 2 years in offspring of participants in the ‘Women First’ maternal preconception nutrition randomised controlled trial. Arch Dis Child. 2023 May 4:archdischild-2023-325352. doi: 10.1136/archdischild-2023-325352. Epub ahead of print. PMID: 37142335. 2. von Dadelszen P, Bone JN, Sandhu A, Ansermino JM, Qureshi RN, Sacoor C, Sevene E, Li J, Vidler M, Bellad MB, Bhutta ZA, Dunsmuir DT, Goudar SS, Mallapur AA, Munguambe K, Dumont GA, Magee LA; CLIP Trials Working Group. Choosing blood pressure thresholds to inform pregnancy care in the community: An analysis of cluster trials. BJOG. 2023 Apr 24. doi: 10.1111/1471-0528.17465. Epub ahead of print. PMID: 37092252. 3. Semrau KEA, Mokhtar RR, Manji K, Goudar SS, Mvalo T, Sudfeld CR, Young MF, Caruso BA, Duggan CP, Somji SS, Lee ACC, Bakari M, Lugangira K, Kisenge R, Adair LS, Hoffman IF, Saidi F, Phiri M, Msimuko K, Nyirenda F, Michalak M, Dhaded SM, Bellad RM, Misra S, Panda S, Vernekar SS, Herekar V, Sommannavar M, Nayak RB, Yogeshkumar S, Welling S, North K, Israel-Ballard K, Mansen KL, Martin SL, Fleming K, Miller K, Pote A, Spigel L, Tuller DE, Vesel L; LIFE Study Group. Facility-based care for moderately low birthweight infants in India, Malawi, and Tanzania. PLOS Glob Public Health. 2023 Apr 19;3(4):e0001789. doi: 10.1371/ journal.pgph.0001789. PMID: 37075019. 4. Harakuni SU, Somannavar MS, Ghanchi NK, Ahmed I, Zafar A, Kim J, Tikmani SS, Hwang K, Saleem S, Goudar SS, Dhaded S, Guruprasad G, Yasmin H, Yogeshkumar S, Aceituno A, Silver RM, McClure EM, Goldenberg RL; PURPOSe Investigators. Pathogens identified in the internal tissues and placentas of stillbirths: results from the prospective, observational PURPOSe study. BJOG. 2023 Apr 17. doi: 10.1111/14710528.17479. Epub ahead of print. PMID: 37069731. 5. World Health Organization Labour Care Guide Research Prioritization Group. Global research priorities related to the World Health Organization Labour Care Guide: results of a global consultation. Reprod Health. 2023 Apr 7;20(1):57. doi: 10.1186/s12978-023-01600-4. PMID: 37029413; PMCID: PMC10082494.

296 Participants

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6. Kumar S, Bhatla N, Sharma KA, Agarwal R, Verma A, Perumal V, Shiv Kumar P, Garg BS, Goudar SS, Pujar YV, Kavi A, Suri V, Joshi B, Rathore A, Gupta MM, Kumar A, Puri M, Meena D, Nangia S, Arora R, Bachani S, Anand P, Seth S, Gupta R, Sehgal R, Rana A, Kumari A, P S, Donimath K, Gowder G, Kedar L, Kar T, Mishra S, Joshi C, Kabade Y, Kamatar S, Nanda S, Mohapatra V, Vellanki J, Agarwal S, Borkar AW, Kumar A, Sultan S, Gangane N, Chaudhary P, Jayathilaka A, Raina N, Karna P; SCOPE Study Group. SCOPE: Surveillance of

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COVID-19 in pregnancy- results of a multicentric ambispective case-control study on clinical presentation and maternal outcomes in India between April to November 2020. PLoS One. 2023 Mar 6;18(3):e0272381. doi: 10.1371/journal.pone.0272381. PMID: 36877672; PMCID: PMC9987819. 7. Perez, K.M.; Asim, M.; Weiss, E.M.; Valentine, G.C.; Kavi, A.; Somannavar, M.S.; Iwuh, I.; Chiweza, C.; Tickell, K.D.; Singa, B.O.; Beima-Sofie, K.; Batra, M.; Walson, J.L.; Umoren, R.; Kelley, M.; Saleem, S. Considering Risks to Researchers and Staff in Low-Resource Settings during Public Health Crises: A Proposed Conceptual Model. Children 2023, 10, 463. https://doi.org/10.3390/children10030463 8. Vesel L, Bellad RM, Manji K, Saidi F, Velasquez E, Sudfeld CR, Miller K, Bakari M, Lugangira K, Kisenge R, Salim N, Somji S, Hoffman I, Msimuko K, Mvalo T, Nyirenda F, Phiri M, Das L, Dhaded S, Goudar SS, Herekar V, Kumar Y, Koujalagi MB, Guruprasad G, Panda S, Shamanur LG, Somannavar M, Vernekar SS, Misra S, Adair L, Bell G, Caruso BA, Duggan C, Fleming K, Israel-Ballard K, Fishman E, Lee ACC, Lipsitz S, Mansen KL, Martin SL, Mokhtar RR, North K, Pote A, Spigel L, Tuller DE, Young M, Semrau KEA; LIFE study team. Feeding practices and growth patterns of moderately low birthweight infants in resource-limited settings: results from a multisite, longitudinal observational study. BMJ Open. 2023 Feb 15;13(2):e067316. doi: 10.1136/bmjopen-2022-067316. PMID: 36792338. 9. Patterson JK, Neuwahl S, Goco N, Moore J, Goudar SS, Derman RJ, Hoffman M, Metgud M, Somannavar M, Kavi A, Okitawutshu J, Lokangaka A, Tshefu A, Bose CL, Mwapule A, Mwenechanya M, Chomba E, Carlo WA, Chicuy J, Figueroa L, Krebs NF, Jessani S, Saleem S, Goldenberg RL, Kurhe K, Das P, Patel A, Hibberd PL, Achieng E, Nyongesa P, Esamai F, Bucher S, Liechty EA, Bresnahan BW, Koso-Thomas M, McClure EM. Cost-effectiveness of low-dose aspirin for the prevention of preterm birth: a prospective study of the Global Network for Women’s and Children’s Health Research. Lancet Glob Health. 2023 Mar;11(3):e436-e444. doi: 10.1016/S2214-109X(22)00548-4. PMID: 36796987. 10. Tita ATN, Carlo WA, McClure EM, Mwenechanya M, Chomba E, Hemingway-Foday JJ, Kavi A, Metgud MC, Goudar SS, Derman R, Lokangaka A, Tshefu A, Bauserman M, Bose C, Shivkumar P, Waikar M, Patel A, Hibberd PL, Nyongesa P, Esamai F, Ekhaguere OA, Bucher S, Jessani S, Tikmani SS, Saleem S, Goldenberg RL, Billah SM, Lennox R, Haque R, Petri W, Figueroa L, Mazariegos M, Krebs NF, Moore JL, Nolen TL, Koso-Thomas M; A-PLUS Trial Group. Azithromycin to Prevent Sepsis or Death in Women Planning a Vaginal Birth. N Engl J Med. 2023 Feb 9. doi: 10.1056/NEJMoa2212111. Epub ahead of print. PMID: 36757318. 11. Vogel JP, Pingray V, Althabe F, Gibbons L, Berrueta M, Pujar Y, Somannavar M, Vernekar SS, Ciganda A, Rodriguez R, Welling SA, Revankar A, Bendigeri S, Kumar JA, Patil SB, Karinagannanavar A, Anteen RR, Pavithra MR, Shetty S, Latha B, Megha HM, Gaddi SS, Chikkagowdra S, Raghavendra B, Armari E, Scott N, Eddy K, Homer CSE, Goudar SS. Implementing the WHO Labour Care Guide to reduce the use of Caesarean section in four hospitals in India: protocol and statistical analysis plan for a pragmatic, stepped-wedge, cluster-randomized pilot trial. Reprod Health. 2023 Jan 20;20(1):18. doi: 10.1186/s12978-022-01525-4. PMID: 36670438; PMCID: PMC9862839.

13. Adu-Amankwah A, Bellad MB, Benson AM, Beyuo TK, Bhandankar M, Charanthimath U, Chisembele M, Cole SR, Dhaded SM, Enweronu-Laryea C, Freeman BL, Freeman NLB, Goudar SS, Jiang X, Kasaro MP, Kosorok MR, Luckett D, Mbewe FM, Misra S, Mutesu K, Nuamah MA, Oppong SA, Patterson JK, Peterson M, Pokaprakarn T, Price JT, Pujar YV, Rouse DJ, Sebastião YV, Spelke MB, Sperger J, Stringer JSA, Tuuli MG, Valancius M, Vwalika B; LABOR Study Group. Limiting adverse birth outcomes in resource-limited settings (LABOR): protocol of a prospective intrapartum cohort study. Gates Open Res. 2022 Dec 19;6:115. doi: 10.12688/gatesopenres.13716.2. PMID: 36636742; PMCID: PMC 9822935. 14. Kavi A, Kinshella MW, Ramadurg UY, Charantimath U, Katageri GM, Karadiguddi CC, Honnungar NV, Bannale SG, Mungarwadi GI, Bone JN, Vidler M, Magee L, Mallapur A, Goudar SS, Bellad M, Derman R, von Dadelszen P, Working Group TCI. Community engagement for birth preparedness and complication readiness in the Community Level Interventions for Pre-eclampsia (CLIP) Trial in India: a mixed-method evaluation. BMJ Open. 2022 Dec 20;12(12):e060593. doi: 10.1136/bmjopen-2021-060593. PMID: 36600428; PMCID: PMC9772674. 15. Goldenberg RL, Saleem S, Billah SM, Kim J, Moore JL, Ghanchi NK, Haque R, Figueroa L, Ayala A, Lokangaka A, Tshefu A, Goudar SS, Kavi A, Sommanar M, Esamai F, Mwenchanya M, Chomba E, Patel A, Das P, Emonyi WI, Edidi S, Deshmukh M, Hossain B, Siraj S, Mazariegos M, Garces AL, Bauserman M, Bose CL, Petri WA Jr, Krebs NF, Derman RJ, Carlo WA, Liechty EA, Hibberd PL, Koso-Thomas M, Peres-da-Silva N, Nolen TL, McClure EM. COVID-19 Antibody Positivity Over Time and Pregnancy Outcomes in Seven Lowand-Middle-Income Countries: A Prospective, Observational Study of the Global Network for Women’s and Children’s Health Research. BJOG. 2022 Dec 12. doi: 10.1111/1471-0528.17366. Epub ahead of print. PMID: 36504437. 16. WHO ACTION Trials Collaborators. Effect of dexamethasone on newborn survival at different administration-to-birth intervals: A secondary analysis of the WHO ACTION (Antenatal CorticosTeroids for Improving Outcomes in Preterm Newborn)-I trial. EClinicalMedicine. 2022 Nov 14;53:101744. doi: 10.1016/j. eclinm.2022.101744. PMID: 36467459; PMCID: PMC9716334. 17. Dhaded SM, Saleem S, Goudar SS, Tikmani SS, Hwang K, Guruprasad G, Aradhya GH, Kusagur VB, Patil LGC, Yogeshkumar S, Somannavar MS, Reza S, Roujani S, Raza J, Yasmin H, Aceituno A, Parlberg L, Kim J, Moore J, Bann CM, Silver RM, Goldenberg RL, McClure EM; PURPOSe study group. The causes of preterm neonatal deaths in India and Pakistan (PURPOSe): a prospective cohort study. Lancet Glob Health. 2022 Nov;10(11):e1575-e1581. doi: 10.1016/S2214-109X(22)00384-9. PMID: 36240824; PMCID: PMC9579353. 18. WHO ACTION Trial Collaborators. Antenatal dexamethasone for improving preterm newborn outcomes in low-resource countries: a cost-effectiveness analysis of the WHO ACTION-I trial. Lancet Glob Health. 2022 Oct;10(10):e1523-e1533. doi: 10.1016/S2214-109X(22)00340-0. PMID: 36113535.

12. Bellad RM, Mahantshetti NS, Charantimath US, Ma T, Washio Y, Short VL, Chang K, Lalakia P, Jaeger FJ, Kelly PJ, Mungarwadi G, Karadiguddi CC, Goudar SS, Derman RJ. A training curriculum for an mHealth supported peer counseling program to promote exclusive breastfeeding in rural India. Int Breastfeed J. 2023 Jan 19;18(1):6. doi: 10.1186/s13006-023-00546-4. PMID: 36658581; PMCID: PMC9850503.

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PARTNERSHIPS

UROLOGY RESEARCH

Consultation/Outreach

20 June 2023

1. MoU with Rajasthan University of Health Sciences for Faculty Development in Medical Education and Research on February 16, 2023

The official research collaboration was activated on July 2017 Outcomes

2. Dr Shivaprasad S Goudar participated in Brainstorming session on Implementation Research (IR) Studies in India - 2022 at National Institute for Implementation Research in Noncommunicable Diseases, Jodhpur 29 December 2022 3. Dr Shivaprasad S Goudar participated in Global Summit on Postpartum Haemorrhage (WHO PPH Summit) on March 7-10, 2023 at Dubai, UAE 4. Dr Shivaprasad S Goudar participated in WHO Consultation on Maternal and Perinatal Health Research during Epidemics and Pandemics May 17-18, 2023 in Geneva Organized by Human Reproduction Program of the Department of Sexual and Reproductive Health and Research Visitors • Dr Rajiv Bahl, Secretary, Department of Health Research & Director General, ICMR visited JNMC Women’s and Children’s Health Research Unit, Belagavi on April 19, 2023

1. The Department of Urology organized an International CME on Uro-oncology on 31st March 2018. Chief Guest & Invited Speaker: Prof. Dr. Leonard Gomella, Dept. of Urology, TJU, USA. • Beneficiaries of the CME: Faculty, PGs & Students (120 delegates) 2. The Department of Urology organized a two-day International Hands-on Workshop on the Diagnosis of Prostate Cancer on 14th & 15th March 2019. • Chief Guest & Invited Speaker: Prof Madhukar Thakur, Dept. Radiopharmaceutical, Radiology & Urology TJU, USA. • Beneficiaries of the CME: Faculty, PGs & Students (20 delegates) 3. The Department of Urology organized an International CME on Diagnosis of Prostate Cancer on 16th March 2019. • Chief Guest & Invited Speaker: Prof Madhukar Thakur, Dept. Radiopharmaceutical, Radiology & Urology TJU, USA. • Beneficiaries of the CME: Faculty, PGs & Students (110 delegates)

Grants Received: Rs.7,70,44,931 4. Urinary Biomarkers Research Centre was established on 1st September 2019 as an outcome of the research collaboration and several projects were executed. • Publications from the VPAC receptors & TP4303 molecule study on Prostate, Bladder, Oral & Cervix 1. Nerli RB, Ghagane SC, Bidi SR, Thakur ML, Gomella L. Voided urine test to diagnose prostate cancer: Preliminary report. CytoJournal. 2021;18. 2. Nerli RB, Ghagane SC, Rangrez S, Chandra S, Thakur ML, Gomella L. Detection of bladder cancer using voided urine sample and by targeting genomic VPAC receptors. Indian Journal of Urology: IJU: Journal of the Urological Society of India. 2021 Oct;37(4):345. 3. Pattnaik SS. Re: Nerli RB, Ghagane SC, Rangrez S, Chandra S, Thakur ML, Gomella L. Detection of bladder cancer using voided urine sample and by targeting genomic VPAC receptors. Indian J Urol 2021; 37: 345-9. Indian Journal of Urology. 2022 Jan 1;38(1):77-8. 4. Nerli R, Kalloli M, Rangrez S, Ghagane SC, Vinchurkar K, Chandra S, Thakur ML. Diagnosis of Oral Cancers by Targeting VPAC Receptors: Preliminary Report. 5. Nerli RB, Vinchurkar K, Kalloli M, Rangrez S, Ghagane SC, Thakur ML. Diagnosis of cancer of the cervix by targeting VPAC receptors on exfoliated cervical cells. Brazilian Journal of Oncology. 2023;19:1-6.

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TJU-KAHER COLL ABORATION 5. Department of Urology organized Live operative international workshop & CME on RIRS and Mini PCNL on 10th & 11th December 2022. Chief Guest & Invited Speaker: Dr. Scott Hubosky, Department of Endourology TJU, USA. • Beneficiaries of the CME: Faculty, PGs & Students (40 delegates)

1 November 2022 – 15 June 2023 Academic Activities Parth Lalakia as Adjunct Faculty takes classes on line Classes on ZOOM

6. Urinary Biomarkers Research Centre Organized an International CME on Advanced Laboratory Techniques on Diagnosis of Genitourinary Cancers on 13th January 2023. Chief Guest & Invited Speaker: Prof Madhukar Thakur, Dept. Radiopharmaceutical, Radiology & Urology TJU, USA. • Beneficiaries of the CME: Faculty, PGs & Students (135 delegates) PRESENTATIONS 1. Dr. Shoubhik Chandra presented an oral podium presentation on “USE OF 5-AMINOLEVULINIC ACID AND NOVEL TP4303 MOLECULE FOR THE DIAGNOSIS OF BLADDER CANCER IN VOIDED URINE AND COMPARISON WITH CONVENTIONAL NON-INVASIVE URINARY BIOMARKERS” at Society International Urology, Montreal Canada, Nov 2022, Won best paper award. 2. Dr. Shweta Rao presented an oral presentation on “MANAGEMENT OF KIDNEY STONES IN PATIENTS WHO HAD RECEIVED CHEMOTHERAPY FOR CANCER” at the Annual Conference of Urolithiasis of USI on 14th & 15th May 2023. Won 3rd Prize in the best paper award category.

The following faculty of TJU School of Population Health have recorded video lectures and shared. These lectures are played for MPH students in relevant semesters.

SNo.

Name of Faculty

Topic

1

Dr. Rosie Frasso

Qualitative Research and Research Design

2

Dr. Henderson Riley

Health Entertainment Education Applied to Public Health

3

Dr. Harriet Okatch

Environmental Public Health

Research Activities Sample collection for pilot study of Periodontal Disease and preterm proposal was completed and Dr Paranjpe is looking into their lab investigation. Student Exchanges

A new study is initiated on Pelvic Organ Prolapse with the following departments: • Urogynaecology • Public Health & Epidemiology • Physiotherapy • Community Medicine

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For the past 4 Years KLE has sent up to 6, top of the class, medical students for observerships in various health discliplines at Thomas Jefferson University. Additionally, a number of TJU students have participated in research programs at KLE.

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NEUROLOGY

KAHER NURSING SCIENCES

Dr. Saroja A O, Professor of Neurology, Jawaharlal Nehru Medical College, KAHER visited department of Neurology TJU from 14th November 2022 to 18th November 2022. During her visit to TJU she had meetings with Professor Rostami (V), Dr. Richard Derman, Dr. Nabeel Herial, Dr. Karuna, Dr. Diana Tzeng.

• • •

Ongoing research grants • Physical therapy in NICU admitted babies • Treatment modalities for head and neck cancer

Discussions were held regarding: O post-doctoral student exchange program O planning of KAHER – TJU global neurology rounds O consideration of stroke workshop / conference in India with faculty from TJU and India.

Publication: Postpartum Depression in India: Perceptions by Key Stakeholders Report of collaboration of Department of Psychiatry, JNMC Belagavi with Thomas Jefferson University Department of Rehabilitation Science, TJU

Research Collaboration • •

She attended Vascular Neurology Grand rounds. Witnessed stroke mock drill.

First KAHER – TJU Neurology grand rounds was organized on 26th May 2023 wherein Dr. Saroja A presented the case scenario of management of drug resistant neurotuberculosis complicated by neuropathy. The presentation was well received and was followed by active discussions regarding the treatment options, management of drug resistant tuberculosis and adverse effects of the conventional and the second line ATT. Dr. Sumanth Chava, 2nd year DM Neurology student of Jawaharlal Nehru Medical College, KAHER has been identified for the Inter-institutional post-graduate student exchange program. Mails have been sent in this regard to the officials at Jawaharlal Nehru Medical College, KAHER and TJU. The suggested period for the DM Neurology student’s visit to TJU is from October 2023 to November 2023 for a period of 3 weeks.

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Pilot study on ‘Postpartum depression’ was conducted in collaboration with KLE University’s College of Nursing Sciences, Department of Psychiatry, JNMC and Thomas Jefferson University. One research paper has been published (Article attached) and one more paper has been submitted (Article attached). Department of Psychiatry conducted series of meetings with Dr. John Lauriello, Professor & Psychiatrist, Thomas Jefferson University and his team, and identified ‘Comparison between socio-demographical variables associated with Suicide among USA and India’ as primary subject of collaborative research. It has also been discussed about participation of psychiatry postgraduate students and junior faculty of JNMC in the regular ‘Grand rounds’ conducted by TJU. Exploring opportunities for dual degree programs in Rehabilitation Science and Population Health

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