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Science-Based Medicine (SBM) for The Novel Pharmacological Use of Medicinal Embryonic Phytotherapy (MEPâ„¢)

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CHAPTER 1 | S cience-Based Medicinal Embryonic Phytotherapy (MEP™)

The Antiaging Superior Pharmacological Properties of MEP & Embryonic Plant Extracts (EPEs) Unsurpassed Regenerative Capacity to Increase Longevity AN EQUAL WEIGHT COMPARISON between embryonic buds and adult plants reveals that the embryonic version contains all the same active phytochemicals but at much higher concentrations and in significantly greater varieties. Indeed, pharma-cological studies comparing the action of embryonic plant extracts and usual tinctures on target organs and tissues clearly demonstrate an increased activity for these extracts. Embryonic plant tissues and embryonic plant extracts (EPEs) are truly a concentrate of vital energies and information.

They contain all the prop-erties of the mature tree in addition to unique juvenile phytohormones and embryonic plant stem cells (PSCs).

To understand comprehensively the workings of MEP, synonymous with “Juvenile Phytohormones,” regarding their regenerative effect, it will be neces-sary to learn the basic science behind human stem cells, as stem cell self-renewal plays a key central role in the understanding of how plants, and their many biological activities, can possibly increase cellular renewal, tissue regeneration, and repair, leading to the revitalization of a worn-out aging body. However, not all plant extracts are equal.

The novel use of embry-onic plant extracts (EPEs), rather than adult plant ex-tracts (APEs), is indispensable in clinical regenerative medicine. This is due to EPEs’ unsurpassed pharmaco-logical superiority attributed to their many antiaging properties.

EPEs are the rejuvenators of dying cells—they not only increase longevity, but also improve quality of life, which is something never observed with APEs. Furthermore, EPEs have real potential in the reversal of many chronic conditions and diseases; this potential is attributed to each plant’s unique and total phytochemical composition, found at higher concentrations in EPEs than in APEs. Of critical im-portance is that EPEs are free of any contaminants, unlike APEs that have had ample time to interact with the environment and are often found to contain toxic metals and other pollutants.

However, it must be noted that until you have first identified the body toxic burden (BTB) through

The Antiaging Superior Pharmacological Properties of MEP

tox-icological testing and then effectively detoxified all concerns, none of this will be possible and these gains will remain elusive. The real potential in the reversal of disease with MEP is greatly contingent on medical knowledge mastery initially, and on phytochemistry proficiency secondly.

Various studies have shown juvenile phytohormones to inhibit the destruction of fibroblast within the cell, thereby increasing elastin and collagen produc-tion; the juvenile phytohormones also significantly augment mitochondrial activity, which increases cellular energy and renewal, resulting in improved skin vitality, hydration, and glow. Furthermore, other studies have shown juvenile phytohormones to be po-tent antioxidants, reducing oxidative stress and related inflammation, as well as capable of DNA repair.

Aging can be defined by a breakdown of homeostasis Aging results from complex genetically and epigeneti-cally programmed processes that are elicited in part by noxious or stressful events that cause programmed cell death (apoptosis). Autophagy is defined as a cytoplasmic recycling process that counteracts the age-associated accumulation of damaged organelles and proteins as it improves the metabolic fitness of somatic cells, sustaining metabolism and homeostasis. The body’s repair mechanisms begin to fail with increasing age. In the spring, nature reawakens and EPEs also reawaken human organisms in profound ways; capable of modulating autophagy and the mammalian target of rapamycin (mTOR), resulting in both somatic cell fitness and homeostasis. NOT increasing indiscriminately, but rather by selective autophagy modulation—mitochondrial homeostasis and somatic cell fitness.

Abscisic acid (ABA) phytohormone increases somatic cell fitness with the synergistic effect of Plant Stem Cells (PSC). The phytohormone Indole-3-Propionic Acid (IPA), one of the five auxins, reverses the age-dependent decline and increases the activity of mitochondrial Com-plex I—generator of half the amount of free radicals produced by the mitochondria’s energetic capacity and increased lifespan. IPA is a potent human kynurenine aminotransferase I (hKAT I) inhibitor to prevent neurodegeneration. Additionally, PSC interrupts defective genes by inhibiting DNA mistranslated information (without the phytohormone cytokinins (CKs), there is, on occasion, mistranslating of the DNA molecules; however, when CKs are present, the DNA is replicated perfectly every time). The juvenile phytohormones—CK derivative meta-Topolin (mT), Gibberellins, Jasmonic acid ( JA), Salicylic acid (SA), and Systemin—all have antisenescence activities via increasing cell renewal and tissue growth by upregulating collagens, hyaluronic acid, and fibrillin—glycoproteins. Homospermidine and Spermidine have the most antisenescence effect of all polyamines, which are inducers of autophagy.

Spermidine is a precursor of the unusual amino acid hypusine—both reduced telomere silencing, shortening, and telomere erosion: increasing telomere length

Juvenile Phytohormones inhibit the destruction of fibroblast.

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and telomerase activity, as well, to prevent tissue necrosis. In recent years, aging has been reported to be regulated by histone acetyltransferase (HAT), and when in the presence of spermidine, the expression levels of histone deacetylase 1 (HDAC1), sirtuin 1 (SIRT1), and phos-pho-p38 (p-p38) are increased.

Spermidine inhibits the activity and expression of 72 kDa type IV collagenase, also known as matrix metalloproteinase-2 (MMP-2), via regulation of HAT and HDAC1 (Park & Kim, 2012). Spermidine and spermine suppressed DNA methylation. Spermidine antiaging properties are necessary for cell growth and maturation and have been found to prolong lifespan proven by both in vitro and in vivo studies, decreasing the occurrence of age-related pathology and loss of locomotor ability (Minois et al., 2014).

Spermidine helps in the stimulation of liver detoxification enzymes; it initiates liver and pancreas regeneration. It also reduces age-related oxidative protein damage. Spermine is an important epidermal antioxidant that is able to penetrate the stratum cor-neum of the skin and is considered to have potent antioxidant activity that is 20-30 times stronger than vitamin E in delaying cell aging (Løvaas, 1995).

Agmatine’s expertise at crossing the blood-brain barrier is why a small molecule can have such a pro-found impact on an aging brain, maintaining optimal cognitive function and longevity, all of which is achieved by increasing the brain neuroplasticity away from sclerotic rigidity in addition to its neuroprotec-tive effect against neurotoxins, preserving neurons from cell apoptosis.

EPEs are selective chelators of toxic metals and detox-ifying agents that only remove the body toxic burden, while at the same time replenishing it with essen-tial nutrients like enzymes, vitamins, and minerals. Ultimately, I know of no other natural modality that is as capable of increasing longevity as what is witnessed with MEP. This is best achieved from the inside out with EPE oral supplements, which have a systemic effect on the entire organism and its rejuvenating effect. Why take only one isolated phytohormone with limited attain-ment that lacks interaction and ultimately is devoid of any real health benefit? Instead, you can, in fact, have the synergistic effect of all juvenile hormones present in EPEs, and you can additionally receive ALL known health benefits that are derived from a specific whole plant species, attributed to its total nutritional and phytochemical composition. In my 40 years of clinical research studies, this systemic approach has consistently proven to be significantly more potent and effective at slowing down the aging process and increasing lifespan. Ultimately, the observed skin benefits look a lot more natural than what is seen with plastic surgery, derma fillers, or Botox injections, and in the long term, you can avoid their risks or side effects, from unattractive or unnatural results to scar-ring to even the risk of death that is always present under anesthesiology. MEP is a knife-free alternative to plastic surgery for those who wish to not only look younger but also feel younger from the inside out.

Anyone taking EPEs orally looks an average of at least 10 years younger than their biological age or as compared to family members and friends of the same age. This difference is usually noted anywhere from two to six months after the commencement of a Biotherapeutic program. These people report many more health benefits beyond just the appearance of their skin, which greatly depends on internal health and is often a reflection of such. They also report increased

The Antiaging Superior Pharmacological Properties of MEP

stamina and energy and an increase in cog-nitive function, in addition to an overall improved and sustained quality of life.

The results reported herein were observed only in acquiescent participants who assumed responsibility for making the necessary lifestyle changes required for any therapy to be successful. Many who previous-ly were suffering from chronic conditions or diseases, and who were compliant with their Biotherapeutic programs and had also made the mandatory lifestyle changes, are currently enjoying the good fortune of a complete reversal of their conditions or diseases that were once deemed incurable but are now a thing of the past. In fact, these corrective results are today sustained and maintained strictly with the continuation from the lifestyle changes made to prevent their reoccurrences. Results like this are never reported from any other methodologies that I know of, and I have studied and researched many.

Unfortunately, there are cases in which a disease’s la-tency and proliferation afford it the time required to inflict sustained permanent damage, thus proving it to be beyond repair. However, on these rare occasions we still do our very best to improve quality of life, even if that is all we can offer.

Conversely, when dealing with behavioral problems, such as addiction(s) or a lack of program and/or dietary compliance, one may be required to remain on a revised and continued Biotherapeutic program to maintain whatever progress was achieved and to prevent progression of a condition or disease. Fifty percent of any Biotherapeutic program’s successful outcome is contingent on a patient’s 100% compli-ant cooperation, not only in taking their program as instructed, but also in making the lifelong and sus-tained dietary and lifestyle changes that are required to graduate to a level of a maintenance program. Approximately 40% of anyone’s diet needs to be com-prised of VEGETABLES, and nothing else will suffice in the prevention of disease.

A partnership between a patient and physician is absolutely vital for the success of any treatment, and both must be made liable. The time invested outside of scheduled visits that is required for physicians to design a custom-made program can be lengthy, and hours spent educating a patient on their specif-ic dietary needs means that they must also be made accountable for not wasting our time, as well.

Further-more, non-compliant patients must be reminded of their responsibility in the outcome of a successful treat-ment. It is never all up to us only; when in doubt, ask them to keep a one-week journal of their diet, and I bet you that more often than not you can trace it back to them doing something incorrect. It takes time to teach nutritional science but with every continued visit, they keep learning more and more. For example, someone who either feels fatigue or is having sleeping problems and drinking alcohol in excess cannot possibly feel better, just like a diabetic patient eating too many sweets or complex carbs will show no improvement on their blood-glucose levels.

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The same accountability should also be reciprocal when a patient who does everything they are told and yet sees no improvement or results whatsoever. In this instance, a physician at no charge should be ea-ger to re-evaluate the patient case study and perhaps do further testing if deemed necessary, as well as to revise their program and then follow up more closely to make sure that improvement ensues. This is a two-way street for which all care practitioners should be made accountable, be more vigilant about and be very concerned when a patient reports a lack of effective-ness, or worse, no improvement. We next have to go back to the drawing table and learn from our mistakes or oversights (hopefully it is never a case of gross negligence). Various studies have shown physicians with good bedside manners and who are friendly, compassionate, and more accessible had fewer cases of malpractice than those who have grown bitter and cold or denuded of any feeling. After all, we are simply humans and do make mistakes.

This is precisely why we need to keep on studying and learning something that only comes from trial and error and our experiences.

Human Stem Cells Overview

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Human Stem Cells Overview STEM CELLS ARE PRIMAL, undifferentiated cells that can reproduce themselves, becoming any type of specialized cell within the organism. This occurs through mitotic cell division, a process in which a cell duplicates its chromosomes and generates two iden-tical cells with an equal distribution of organelles and other cellular components. One of the cells remains of the original “stem cell� state, while the other one that was created becomes differentiated (Tuch, 2006).

This cell-differentiating property represents a poten-tially unlimited source of healing capacity that spans the full spectrum of healing. A medicinal agent that can stimulate the multiplication and differentiation of stem cells can repair everything, from repairing specific tissues to growing organs. PSC can stimulate the repair of specific tissues, whereas only human stem cells are capable of growing new organs. Stem cells (undifferentiated cells capable of dividing and differen-tiating into a cell type specific for an organ’s function) are found in all multi-cellular organisms, including humans, animals, and plants (Allman, 2006).

Embryonic Stem Cells These cells are derived from blastocyst; they are stem cells found in the early stage of animal/human development, early in pregnancy, and can differentiate into all the specialized embryonic tissues. As is well known, the ethical and political concerns surround-ing human embryonic stem cells stand in the way of developing workable therapies (Thomson et al., 1998). Meristematic cells (plant stem cells) are analogous in function to stem cells in mammals.

The three broad categories of mammalian stem cells are Embryonic, Adult, and Cord Blood. Each is described below and on the following pages.

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Adult Stem Cells These cells are found in both adult and child tissues and are thus free from controversy since they require no embryonic destruction. They can divide or self- renew indefinitely and can generate all the cell types of the organ from which they originate. They can potentially regenerate the entire organ from a few cells (Mlsna, 2010). The origin of adult stem cells in mature tissues is unknown (NIH, 2016).

Cord Blood Stem Cells These cells are found in the blood from the umbilical cord and the placenta.

They have been utilized as a source of primary embryonic stem cells for transplan-tation (Tuch, 2006).

Until recently, it was thought that the stem cells found in an organ could only differentiate into one specific cell type to regenerate the tissues of that organ. However, recent evidence shows that stem cells from a specific organ can transform into several other tissue types. For example, bone marrow stem cells are known to be able to transform into liver, nerve, muscle, and kidney cells (Weizmann Institute, 2003).

Various adjectives describe the developmental potential of stem cells, including: TOTIPOTENT, PLURIPOTENT, and MULTIPOTENT.

Totipotent Cells These cells have the potential to become any type of cell in the adult body (as well as any cell of the placenta). A totipotent cell can replicate and differentiate enough times to ultimately develop into a human being. The totipotent cell that is created after a sperm fertilizes an egg divides into an identical totipotent cell a few hours after fertilization. A few days later, these totipotent cells specialize into pluripotent cells, which give rise to most tissues needed for fetal development. In the plant king-dom, this can be seen in the development of an entire plant from a mere plant cutting. (“Totipotent stem cell� is, in fact, a misnomer, since in mammals this type of cell cannot reproduce itself ), (NIH, 2016).

Pluripotent Cells These cells, which are isolated exclusively from embryonic or fetal tissue (or cultures using special-ized methods), have the potential to differentiate into many cell types. Pluripotent stem cells can develop into any of the three major tissue types: endoderm (interior gut lining), mesoderm (muscle, bone, blood), and ectoderm (epidermal tissues and nervous system). Pluripotent stem cells can eventually specialize into any bodily tissue; however, they cannot develop into a human being. In plants, these stem cells are known as meristematic cells (NIH, 2016).

Multipotent Cells These cells, which are found in adult animals/humans, can only differentiate into a limited number of cell types. For example, bone marrow contains multipotent stem cells that give rise to all the cells of the blood and NOT to other cells types.

The actions from plant stem cells in humans and animals are pluripotent and multipotent. However, the entire full potential from MEP can never be ac-

Human Stem Cells Overview

complished until the body has proceeded through the various necessary steps for healing—only then can regeneration occur, when the body burden has been fully identified and completely removed. The success of MEP is also contingent on the physician’s knowledge, proficiency, experience, and mastery of embryonic phytochemistry. First, a physician must direct the successful detoxification process from toxic cells and tissues, thus liberating the body burden. Entrapped toxins will advertently regain organ functions to more optimum levels, and only as a last step can cellular and tissue regeneration ensue (NIH, 2016).

Phytochemicals Involved in Multipotent Cells and Tissue Processes Affected by MEP • Stimulation of cells by plant growth hormones (PGH), which cause tissue excitation and toxins elimination.

• Antioxidants, which lower the reactive oxygen species, resulting in reduced oxidative damage.

• Enzyme phytochelatin synthases, which have an affinity for toxic metals, bind these toxins by pooling them so they will not exert their toxic effects in preparation for excretion-elimination out of the body.

• Juvenile phytohormones and some phyto-chemicals, which are cytotoxic by inducing programmed cells death (apoptosis) in dysplas-tic and infected cells (e.g., viral, bacterial, and fungal or parasitic), thereby protecting the or-ganism from the development of cancers and microbial infections. The chelation of toxic metals from cells restores the functionality of the cellular apoptotic machinery.

After normalizing these processes, the body has a strong cellular foundation from which to stimulate regeneration of healthy cells and tissues, thereby restoring organ function and achieving homeostasis.

There are many other phytochemicals that participate in the processes of a specific biological activity, detox-ification, and regeneration, but the above list provides a concise overview of the terrain process by which regenerative medicine can possibly ensue.

This fine orchestration of nature and its synergistic effects occur only from the administration of embryonic plant ex-tracts (EPEs) as used in MEP—Biotherapy (Bio mean-ng life, so Biotherapy is an essential-to-life therapy).

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Human stem cell therapy has the unmatched potential for growing limbs and organs (due to its totipotency), but has NO detoxification or nutritive capacities because human embryonic stem cells do not contain antioxidant phytochemicals, juvenile phytohormones, phytochelatin enzymes, etc., all of which distinguish MEP from human stem cell therapy.

MERISTEMATIC STEM CELLS, also known as PLANT STEM CELLS (PSCs)

MERISTEMATIC STEM CELLS, also known as PLANT STEM CELLS (PSCs) A MERISTEM IS A PLANT TISSUE that consists of undifferentiated cells that remain forever young and divide throughout the life of the plant. Meristematic cells are the stem cells of the plant world, and they are found in all embryonic growth; the buds, growing tips, young shoots, roots, embryonic seeds, bark, and sap in plants. It is from these stem cell populations that flowers have Figure 1: Beech–Fagus the unique ability to produce new organs continuously. In some species, they Sylvatica (buds) Plant Stem can continue this process for hundreds of years. Following are two types of mer- Cells (PSCs). istems:

Apical Meristems (Primary) These are found in the buds and growing tips of roots in plants. They are completely undifferentiated and are responsible for forming new buds and extending the plant body.

• Shoot apical meristems are the precursors of all cells that make up stems, leaves, branches, and flowers.

• Stem cells in the root apical meristems are the source of all the cells of the primary and lateral root system. Their totipotent stem cells remain active throughout the life of the plant — unlike

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those of an animal past its embryonic stage—enabling the growth of new organs throughout the course of many years.

However, a plant’s exceptional ability to produce an unquantifiable number of stem cells can backfire. Too quick of an increase could produce uncontrolled growth, similar to cancer, and too sudden of a de-crease could stunt the plant growth; thus, a correct balance in the number of stem cells is necessary. The regulatory mechanism to achieve this equilibrium involves growth-promoting hormones and genetic factors. For example, the hormone cytokinin will not produce its full growth-promoting effect in tissue unless the WUSCHEL regulatory gene is active. This hormone-gene mechanism explains why a hormone may produce different effects in different tissues.

Apical meristems give rise to three primary meristems: 1. Protoderm, which gives rise to the outer, protective coating of the plant.

2. Procambium, which gives rise to the vascular tissue.

3. Ground meristem, which gives rise to ground tissue.

Lateral Meristems (Secondary) These are responsible for lateral growth and thicken-ing of the plant. They produce the secondary tissues, which constitute the secondary plant body.

Lateral meristems are called cambia (cambium) and are of two types: 1. Vascular cambium, which gives rise to secondary vascular tissue.

2. Cork cambium, which gives rise to mostly cork.

MEP is a LIVING THERAPY BIOMEDICINE, Biotherapy Capable of Revitalizing an Entire Organism

MEP is a LIVING THERAPY BIOMEDICINE, Biotherapy Capable of Revitalizing an Entire Organism Biophotons Biophotons, which are found in all biological tissues, typically produce an observed radiant emittance in the visible and ultraviolet frequencies spectrum that facil-itate a form of cellular-crosstalk-communication in the human body. Biophotons are known to restore the electrons’ cell walls, thus protecting our cells from inva-sion. For pathogen recognition and activation of defense signaling networks, biophotons keep an equilibrium between oxidative stress and antioxidant activity.

We are Beings of Light, according to Albert Einstein, with E=MC².

Everything = Energy = Light Manifesting as Reality w/ Density = We are Light

A New Understanding of Life is Derived from Quantum Optics Biophoton biophysical interpretation of the phenom-ena is based on a new understanding of life derived from quantum optics discovery, non-equilibrium thermodynamics, and other recent developments in science, which today is accepted by a growing minori-ty of researchers in the field.

No one denies that free radical reaction oxidation and other biochemical processes occur and may generate some of the light emitted by these reactions. However, we also see biophoton emission mainly as the expres-sion of an overall regulating energetic field in the organism, which also shows that chemiluminescent events are embedded. This is in contrast to the clas-sical molecular view from the biochemical school of thought that describes the organism as a macroscopic quantum system in which not the particle aspect, but that of a holistic field aspect, predominates.

Coherent Radiation Field

It is assumed that all the molecules of the organism are coupled with each other by a coherent radiation field in such a way that they form a unity in which biophotons cannot be assigned any more to any emitters but must instead be emitted by the or-

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ganism as a whole.

The analysis of biophoton measurements has shown that the emitting matter forms a biological laser mech-anism, which at the same time is an experimental confirmation of the view that the organism is an open system far from thermodynamic equilibrium.

Biophotons Control All Life Processes This coherent biophoton field, which permeates and envelops the solid body, is assumed to regulate and control all life processes in the organism.

This hypothetical mechanism assumes that the laser mechanism of biological systems operates not only with the low-grade coherence known from technical optics but uses the ideal quantum-optical coherence defined by Harvard physicist Roy J. Glauber in 1970. Professor Fritz-Albert Popp, a well-known biophysi-cist at Kaiserslautern University, Germany, believes the quantum field of living systems realizes the form of a “coherent state,” a paradoxical state with minimal quan-tum uncertainty that unites the properties of wave and particle, coherence and incoherence, and localization and delocalization (Popp, 1999).

All the evidence of biophoton research points to the idea that biological systems realize a form of optimal coherence that science has yet to fully understand and elucidate.

The measurements show evidence for the existence in biological systems of a new class of quantum phenomena recently investigated by several very advanced disciplines of quantum optics and electro-dynamics, such as Non-Classical Light and Cavity Quantum Electrodynamics.

A New Picture of the Organism The experimental findings of biophoton research, together with recent insights from other fields of advanced science, are suggesting an entirely new picture of the living organism.

First, as a complement to the solid body of molecules, we have an important new component or aspect of the organism to consider, namely the “electromagnetic field body” (Zhang, 2003). From this point of view, the living organism appears as a highly complex and self- tunable resonating system of oscillating fields that are coupled non-linearly by their phase relations (Bischof, 2003).

If we consider the role of the molecules, the organism can be defined as an extremely sensitive and highly effective antennae system of perception especially to external stresses, able to tune itself according to need by a broad range of frequencies and polarizations. Let’s not forget the role of oscillation system.

The organism can react sensitively to the smallest stim-uli, but at the same time can also abruptly become transparent for quite strong stimuli.

Organism of Living Light “Biophoton emission is a general phenomenon of living systems. It concerns low luminescence from a few up to some hundred photons per second, per square centimeter surface area, at least within the spectral region from 200 to 800nm.

The experimen-tal results indicate that biophotons originate from a coherent (or/and squeezed) photon field within the living organism, its function being

MEP is a LIVING THERAPY BIOMEDICINE, Biotherapy Capable of Revitalizing an Entire Organism

intra and intercel-lular regulation and communication” (Popp, 1999).

We are Primarily Energetic and Informational Beings with field-dependent chemical reactions.

Typically, the treatment of biological effects of electro-magnetic (EM) fields is restricted to ionizing radiation and cell membrane potentials. But Integrative Bio-physics is more than a molecular-genetic approach to biology. It focuses on our intrinsic systemic holism, an inseparable whole with the environment, interconnec-tion within and without the organism.

Popp states: “All living organisms emit certain electromagnetic waves. If they are in a healthy condition, they emit more. If not, they emit less. This electromag-netic emission is called biophotons.”

All living cells from plants to human beings emit bio-photons, ultra-weak photon emission of electromagnetic wave in the optical range of the spectrum. Biophotons can’t be seen with the naked eye but can be detected.

When we are under higher levels of oxidative stress, reactive oxygen species (ROS) with depleted store of antioxidants emits another source of light—it can be deemed to constitute a “distress signal,” or background chemical noises, and a process that still remains to be completely elucidated (Davis, 2002).

Biophotonics is a rapidly increasing field of current scientific research and applications, based on the discovery of biophotons, a permanent, weak photon current emanating from all living systems. The bio-photon emission reflects some, if not all, of the essen-tial biological and physiological activities in biological systems. Energy and information can move about the body through other means than nerve transmission and hormonal regulation via quantum coherence.

The Zone of Maturation The region of the root where completely-functional cells are found is called the Zone of Maturation.

Light not only brightens our world by day and makes us see the things around us, it is also produced by our own cells and forms a major component of man’s inner environment, as well as a non-material part of our bodies that connects us with the outer environment.

(Left) Figure 2: Cell Mitosis.

(Right) Figure 3: Biophoton Energy.

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