MEMC - GREAT Rome (Italy), 05/09/2015 - 09/09/2015 Topic: Airway / Analgesia / Anesthesia /Sedation / Pain Management
W256
A COMPARISON BETWEEN ANALGESIC EFFECT OF INTRAVENOUS ACETAMINOPHEN VERSUS INTRAVENOUS MORPHINE SULFATE FOR ISOLATED DIAPHYSIAL LONG BONE FRACTURES
B. Zarmehri 1, M. Talebi Doluee 1, B. Rezvani Kakhki 1, M. Salehi 2, M. Talebi 3
1
Mashhad University Of Medical Sciences-Department Of Emergency Medicine, Mashhad, Iran, 2 Mashhad University Of Medical Sciences-Department Of Community Medicine, Mashhad, Iran, 3 Mashhad University Of Medical Sciences-Department Of Psychiatry, Mashhad, Iran Background: To compare the analgesic effect of intravenous acetaminophen with intravenous morphine sulfate in patients with traumatic diaphysial long bone fracture. Methods: This double-blind randomised clinical trial addressed the analgesic effect of intravenous acetaminophen comparing with intravenous morphine sulfate in patients with isolated diaphysial long bone fracture in an urban trauma center of Mashhad city,Iran, for February-June 2013. The patients were 18-65 years old with isolated long bone diaphysial fracture, received acetaminophen 15 milligrams per kilograms weight or morphine sulfate 0.1 milligrams per kilograms weight randomly. The pain severity measured with visual analogue scale before drug administration and then 5 and 30 minutes after drug administration. Then the results were compared. Results: 50 patients were recruited over 5 months. The pain severity was estimated with visual analogue scales before and 5 and 30 minutes after injection. Significant difference was observed between the group receiving intravenous acetaminophen compare with the morphine sulfate group after 5 minute of analgesic administration (P<0.0001) but there was no significant difference in pain severity after 30 minutes between two groups(P= 0.851). Conclusions: It seems that the analgesic effect of intravenous acetaminophen is comparable with intravenous morphine sulfate in isolated diaphysial long bone fracture.