Paediatric Dept. Annual Report - 2012 by Department of Paediatrics - University of Calgary

Department of Paediatrics

2 0 12 A n n u a l R e p o r t

Serving Today and Building Foundations for the Future

February 2013 This reports includes data and events from the calendar year 2012, and academic year July 2011 â&#x20AC;&#x201C; June 2012 Respectfully submitted by: James D. Kellner MD, FRCPC Professor and Head, Department of Paediatrics University of Calgary and Alberta Health Services â&#x20AC;&#x201C; Calgary Zone

Department of Paediatrics Vision, Mission, Values

Table of Contents

InTRoDUCTIon

Introduction

Department Organization and Leadership

The University of Calgary and AHS, Calgary Zone, Department of Paediatrics provides care at all levels to infants, children and adolescents from Calgary and throughout Alberta as well as our extended referral areas in british Columbia and Saskatchewan.

Section of Infectious Diseases Section of Medical Genetics Section of Neonatology Section of Nephrology Section of Neurology

South Campus Hospital

VISIon, MISSIon, VALUES

Description of Department Members

Section of Oncology

Department Demographics

Behavioural Research Unit

Admin, Support and Research Staff

We are deﬁned by our vision, mission and guiding values. These statements deﬁne who we are, how we conduct ourselves, and our purpose as a Department and as individuals.

vISIon Excellence in clinical service, Advocacy & Leadership,

research & Education (c.A.r.E.)

to promote, maintain and restore health in children by:  delivering high quality evidence-based clinical care

Priorities for Children in Calgary Overview of Clinical Sections and Divisions and Research Units

Research Units: Research Methods Dr. Suzanne Tough Respiratory Rheumatology

 innovation and dissemination of new knowledge

Section of Community Peds Section of Critical Care Section of Developmental Peds Section of Emergency Medicine

 respect

 integrity

 collaboration

 Leadership

 innovation

Section of Endocrinology Section of Gastroenterology Section of Hematology Section of Hospital Pediatrics

Education Overview canuc-peds Program descriptions Translation Symposium

Awards

New Faculty

Research Funding

PEACH

 compassion

Highlight: BMT Clinic STEP

CATS Section of Cardiology

Clinical Care Department data

Division of Adolescent Medicine

 training care givers at all levels

vA lUeS

Section of Palliative Medicine

NICU

MISSIon

Special Feature: Epilepsy

Tropical Medicine Clinic

High Impact Publications

131 Research Publications

Department of Paediatrics | Annual Report 2012

Annual Report 2012 | Department of Paediatrics

Introduction

Welcome to the University of Calgary and Alberta Health Services – Calgary Zone Department of Paediatrics (http://www.ucalgary.ca/paed/). The Department has four fundamental activities: 1. Provision of all levels of clinical services to infants, children and adolescents in Calgary, throughout Alberta and other provinces; 2. Training the next generation of healthcare professionals caring for children and their families, and continued training for current healthcare professionals; 3. Knowledge generation and innovation in clinical care and education through the conduct, dissemination and translation of research; 4. Provision of leadership throughout clinical and academic health systems. We have grown to over 300 clinical and academic faculty members in 20 clinical sections and divisions, and 2 academic units. The hub of our clinical services is the 135 bed

Alberta Children’s Hospital which last year (2011-12) received over 237,000 outpatient clinic visits, over 65,000 emergency department visits and 7300 admissions. We provide neonatal intensive care unit (NICU) care at the Alberta Children’s Hospital, Foothills Medical Centre, Peter Lougheed Centre and Rockyview General Hospital. Last year, nearly 3000 babies were served in our NICUs. We also provide paediatric inpatient service at the Peter Lougheed Centre, as well as general paediatric and subspecialty ambulatory clinical services throughout Calgary. We provide palliative and respite care at the Rotary Flames House, located beside ACH. Our physicians travel to provide hundreds of outreach clinics throughout southern Alberta. The population we serve continues to grow. Last year there were over 18,000 births in the Calgary zone. The Government of Alberta estimates that the number of births will continue to increase to nearly 20,000 per year by 2021 and that the number of infants, children and youth aged 19 and under will increase by 20% from 333,530 in 2012 to 399,590 in 2021 (“Alberta Population Projection 2012-2041”).

We teach health professionals at all levels throughout the University of Calgary, as well as SAIT and Mount Royal College. There are 12 Royal College of Physicians and Surgeons of Canada Paediatric Residency Training Programs in Calgary (http://medicine.ucalgary.ca/postgrad). In 2011-12, 93 medical residents and fellows were being trained.

Neonatology and the Paediatric Intensive Care Unit. The Sections of Hospital Paediatrics and Medical Genetics each have an Alternate Payment Plan (APP). Several PhD members of the Department are supported by the ACH Research Institute (ACHRI) and several department members have salary awards from external research agencies.

Department members initiate or participate in biomedical, clinical, health services and population/public health research. Our main research partner is the ACH Research Institute for Child and Maternal Health (ACHRI, www.ucalgary.ca/research4kids/).

Overall, we are able to provide excellent clinical care to the children and families who we serve. We also make excellent contributions to education, research, advocacy and medical leadership. Our workforce has increased substantially over the last decade. Our main challenges, at the end to 2012, are two-fold. First, the facilities and institutions built to support pediatric services in Calgary and area are strained. The population growth over the last decade far exceeded projections and growth continues, at a time when there are limited opportunities to increase pediatric facilities. Second, the outlook for funding of academic departments in Alberta (through AARPS) is currently very uncertain and the outlook for overall physician services funding in Alberta is unsettled.

The Alberta Children’s Hospital Foundation provides generous support to services in the hospital and to research (www.childrenshospital.ab.ca). Funding of faculty in the Department of Paediatrics is complex. Fee-for-service funding remains the main source of funding. The Paediatric Academic Alternate Relationship Plan (Academic ARP) supports about 100 FTEs. There are separate Clinical ARPs for each of

DEPARTMENT OF PAEDIATRICS | AnnUAl RePoRt 2012

AnnUAl RePoRt 2012 | DEPARTMENT OF PAEDIATRICS

Department Organization and Leadership Dean Faculty of Medicine

Zone Medical Director Calgary Department Head Paediatrics Dr. Jim Kellner

Deputy Head Clinical & Strategic Affairs Dr. Mike Leaker Deputy Head Professional Affairs Dr. Val kirk Deputy Head education Dr. Ron Anderson Safety leader Dr. Roger galbraith Department Manager wes Schreiber

AARP Controller Marco Romanzin Physician Affairs Coordinator kellie Mckeil Coordinator Physician Remuneration and Contracts karen Rudd Manager of Administrative Services Alanise Featherstone neonatology ARP Financial Analyst Pat Culham Billing Coordinator Tammy bouchard

Sections, Divisions, Units

UMe, PGMe, CMe Programs and Directors

• • • •

•

Undergraduate Medical education – Dr. Susan bannister

•

Post-Graduate Medical education · General Paediatrics – Dr. kathy Tobler · General Paediatrics – Dr. Deb Fruitman · Developmental Paediatrics – Dr. ben gibbard · emergency Medicine – Dr. graham Thompson (Acting) · endocrinology – Dr. Jonathan Dawrant · Gastroenterology – Dr. Leanna Mckenzie · Hematology/Bone Marrow transplant – Dr. Macgregor Steele · Infectious Diseases – Dr. Rupesh Chawla · Medical Genetics – Dr. Mary Ann Thomas · neonatology/Perinatology – Dr. Majeeda kamaluddeen · nephrology – Dr. Lorraine Hamiwka · neurology – Dr. Jean MahRespirology – Dr. Marielena Dibartolo

•

Continuing Medical education – Dr. Julian Midgley

• • • • • • • • • • • • • • • •

Behavioral Research Unit – Dr. Deb Dewey Cardiology – Dr. Frank Dicke Critical Care – Dr. Simon Parsons Community Paediatrics – Dr. Stephen wainer · Child Abuse – Dr. neil Cooper Developmental Paediatrics – Dr. JF LeMay · Adolescent – Dr. April elliot emergency Medicine – Dr. Angelo Mikrogianakis endocrinology – Dr. Daniele Pacaud Gastroenterology – Dr. Steve Martin Genetics – Dr. Francois bernier Hematology – Dr. Michael Leaker Hospital Paediatrics – Dr. Michelle bailey Infectious Diseases – Dr. Susan kuhn neonatology – Drs. Albert Akierman, Anne Tierney (Acting) nephrology – Dr. Julian Midgley neurology – Dr. Jong Rho oncology/Bone Marrow transplant – Dr. Doug Strother Palliative Care – Dr. Marli Robertson Respirology – Dr. Mark Anselmo Rheumatology – Drs. Heinrike Schmeling/ nicole Johnson (Acting) Research Methods team – Dr. gillian Currie

Site Chiefs •

Paediatrics · FMC – Dr. Chris Lever · PlC – Dr. kelleigh klym · RGH – Dr. Darryl Palmer

•

neonatology · ACH – Dr. Alixe Howlett · FMC – Dr. Anne Tierney · PlC – Dr. Albert Akierman · RGH – Dr. Deborah Clark

Department of Paediatrics | Annual Report 2012

Annual Report 2012 | Department of Paediatrics

Special Feature

Department of Paediatrics at the South Health Campus Construction of South Health Campus (SHC) began in August of 2007, and at the end of 2012 and the beginning of 2013 its doors are beginning to open. SHC is modeled on a somewhat different philosophy than the traditional hospital based on four foundational pillars of care. These pillars include Collaborative Practice, Innovation, Patient & Family Centered Care and Wellness. The goal is to deliver services within the community surrounding SHC by integrating leading technology, research and education with the unique healing environments that are facilitated at the site and a progressive, environmental design.

centered care, joint decision making, as well as respecting and valuing the different roles of the patients and all health care providers. A trusting and open communication style along with sharing accountability in a just and equitable way for patient care is also a large component of this pillar of collaborative practice. Innovation can mean a number of things; it can be the ability to make changes that result in a more effective type of patient care or looking at how we are doing things with a new lens and determining how we can improve patient care. It could be incorporating a new idea into a patient’s care or perhaps using an existing idea that is present in the region or even nationally or internationally, but applying it in a new setting.

As soon as you walk into the building there is a feeling of a community fostered by its unique design. An in house YMCA with a climbing wall, large open spaces, single bed patient rooms with exterior views, wide corridors, gardens and artwork throughout the building and a retail space made to feel more like a café, is all part of the design created to provide wellness, knowledge and education to all who are there. Other services are also available including health resources and knowledge centers and an interactive and demonstrative wellness kitchen.

The last of these foundational pillars is Family and Patient Centered Care. This goal is for families to be partners in care in a supportive and respective environment for patients and health care providers. There has been a new approach taken to the communication style between staff as well as between staff and patients. A new method known as NOD has been adopted. NOD stands for Name, Occupation and Duty. When providers arrive at a patient’s door they will tell families who they are, their role and why they are there. A communication white board will also be at every bedside so that families questions can be addressed appropriately and to ensure clear communication lines between all those providing care. A Citizen Advisory Team is also going to advise on how to enhance things for patients and families being cared for in the hospital.

Collaborative Practice includes ensuring safe and quality care, a focus on patient and family

Dr. Harish Amin is the Medical Site Lead for Paediatrics at the South Health Campus and

has been a leader in facilitating and educating individuals on the role of the Department of Paediatrics at this new site. Paediatric Emergency is housed within the Emergency Department at SHC and opened with all Emergency services on January 14, 2013. In its first three days after opening 30% of all emergency visits have been paediatric patients. It is anticipated that it will get busier but currently Paediatric Emergency physicians offer 12 hours of coverage in the department daily. General and subspecialty clinics will be opening

around the end of May 2013 and are all housed on the 7th floor of SHC along with the 16 bed Level II Neonatal Intensive Care Unit (NICU). It is projected that the NICU will open along with labor and delivery services on September 3, 2013. Some clinics that will be offered at SHC include Asthma, Neurology, General Paediatrics, Weight Management and some Nephrology clinics. As more subspecialists come on board with recruitment the hope is to also offer other subspecialty clinics including Allergy and Immunology and Developmental Paediatrics Clinics starting in 2014.

Department of Paediatrics | Annual Report 2012

Annual Report 2012 | Department of Paediatrics

Description of Department Members

Department Demographics (July 2012)

Alberta Health Services Clinical Department (July 2012)

Number of primary clinical members, by age (n=286, median=46, range 28-80)

297 members with AHS appointments in Calgary or other Zones

• 246 primary appointments in Calgary, 44 supplementary appointments

• Largest 4 sections (45% of all members) ·· Community Pediatrics (48 primary, 4 supplementary)

·· Emergency Medicine (33 primary, 10 supplementary) ·· Hospital Pediatrics (30 primary, 0 supplementary)

·· Neonatology (19 primary, 0 supplementary) 20

• 15 other sections each have 3 to 15 members.

University of Calgary Academic Department (July 2012)

<35

35-39

40-44

45-49

50-54

55-59

60-64

65-69

>70

60-64

65-69

>70

304 members with academic appointments • 276 MDs, 28 PHDs

Number of primary clinical members, by age and sex

·· 253 with primary appointments

·· 51 with cross appointments çç Genetics, Oncology, Neurosciences, Psychiatry, Radiology, etc.

50 40

Academic Status Status

Primary Appointments (253)

Cross Appointments (51)

Clinical*

Adjunct˄

GFT

Clinical

Adjunct

GFT

Lecturer

Assistant Professor

115

Associate Professor

Full Professor

Totals

172

*Includes Major Clinical appointments ^Adjunct includes also Research, Honorary and Emeritus appointments

20 10 -

<35

35-39

40-44

45-49

50-54

FEMALE

55-59 MALE

Overall: 48% female/52% male Amongst members <50 years old – 65% female; amongst members 50 years or older – 35% female

Department of Paediatrics | Annual Report 2012

Annual Report 2012 | Department of Paediatrics

Administrative, Support and Research Staff Department Administrative Offices Wes Schreiber - Department Manager Pat Culham - Neonatology ARP Financial Analyst Alanise Featherstone - Office Manager Kellie McKeil - Physician Affairs Coordinator Marco Romanzin - AARP Controller Karen Rudd - Physician Contracts and Remuneration Coordinator Tracey Boyle - Administrative Assistant Karen Croucher - Administrative Assistant (Drs. Kellner and Leaker) Leena Landry - Clerk Jodi-Lyn McCaw - Administrative Assistant Claire Trojan - Administrative Assistant (Drs. Anderson and Kirk) Tammy Bouchard - Billing Coordinator Kelly Craig - Billing Clerk Patricia Royle - Billing Clerk There are over 75 administrative assistants, other support staff and research staff who support the department at all AHS and U of C sites.

Department of Paediatrics | Annual Report 2012

Annual Report 2012 | Department of Paediatrics

Priorities for Children in Calgary – Key Stakeholders Alberta Health Services The “Alberta Health Services 2011-2015 Health Plan” describes some of the notable facts about infants, children and youth in Alberta. Alberta has the third highest fertilityrate of all Canadian provinces and 23% of all Albertans are less than 18 years of age. The largest number of births are in the Calgary Zone (18,765 in 2009, 37% of provincial total). The infant mortality rate in Calgary is the lowest in the province (5.1/1000 births, range 5.1-7.7) as is the teen pregnancy rate (12.2/1000 teens, range 12.2-39.0). However the percentage of births with low birth weight is the highest in Calgary (7.7%, range 5.6-7.7%). The 2011-2105 Health Plan states that Albertans should, “live longer and enjoy a high quality of life, through a focus on children and families, injury and disease prevention, and healthier social and physical environments.” However, there are few actual priorities related to children. These include: 1. TIP (Transformational Improvement Programs) - Building a Primary Care Foundation • Priority: Improving immunizationrates. • A ctions: In conjunction with zone operations, develop plans to address childhood immunization rates. • M easurements: Influenza vaccine, children aged 6-23 months; DTaP/Polio/ Hib and MMR vaccination status by 2 years 2. TIP - Building a Primary Care Foundation • P riority: Improve the availability and accessibility of addiction and mental

çç Preschool developmental screening. çç Safe infant sleep. çç Healthy births: jointly with AHW, increase support to healthy births including those targeted at FASD.

health services for Albertans in community settings, especially services for children and youth. • A ctions: Improved services for children and youth at risk; Continue to implement the Children’s Mental Health Plan for Alberta. • M easurement: Percentage of children aged 0 to 17 years receiving scheduled mental health treatment within 30 days. 3. TIP - Improving Access, Reducing Wait Times • P riority: Reduce the length of stay for emergency department patients. • A ctions: Add 12 new treatment spaces to emergency department at Stollery Children’s Hospital • Measures: Various ED activity measures. 4. Staying Healthy/Improving Population Health • Priority: Improve population health • Actions (In collaboration with AHW): ·· Injury prevbention. ·· Healthy development/Healthy living. Develop strategy to implement provincially “A Million Messages” – a comprehensive plan to standardize messages given to parents. Messages are simple, consistent, routine, and target children’s issues at the appropriate developmental stage. ¡¡ Screening. çç Newborn metabolic screening: provincial standards and guidelines developed and implemented.

çç Healthy Alberta: work with AHW to promote healthy eating and active living through communities and school. ·· Addiction and Mental Health ¡¡ Complete evaluation of mental health promotion resources for children, youth and parents and determine future options. • Measurements: Life expectancy, potential years of life lost. 5. Chronic Disease • Asthma and mood disorders are key health issues for Alberta children • Obesity rates are escalating both provincially and nationally. Childhood obesity rates have doubled in the past 20 to 30 years while fitness levels have declined significantly since 1981. 6. Injuries • Injuries are the leading cause of death for Alberta children and youth between one and 19 years of age. 7. Urban/Rural Differences • Demographics and Health Needs – Service Response Required: ·· Focus on wellness and health promotion, with particular attention to supporting healthy early childhood. 8. Sustainability Challenges • “The Marmot Review (2010) outlines six policy objectives that must be met

if health equity is to be achieved: give every child the best start in life; enable all children, young people, and adults to maximize their capabilities and have control over their lives; create fair employment and good work for all; ensure a healthy standard of living for all; create and develop healthy and sustainable places and communities; and strengthen the role and impact of ill-health prevention .” The “AHS Performance Report Q2 2011/12 December 2011, Prepared by Data Integration, Measurement and Reporting (DIMR)” lists the following measurements specifically related to children. 1. Immunizations • Children (6 to 23 Months) Influenza Immunization Rate • Childhood Immunization Rate Diphtheria, Tetanus, Pertussis, Polio and Haemophilus Influenzae type b • Childhood Immunization Rate for Measles, Mumps, Rubella 2. Children Receiving Community Mental Health Treatment within 30 Days (%) – Scheduled. 3. The following ED measurements include paediatric data from Alberta Children’s Hospital as one of “…Higher Volume EDs” or “All Sites” from across Alberta. • Patients Discharged from Emergency Department or Urgent Care Centre within 4 hours. • Patients Admitted from Emergency Department within 8 hours. • Patients Admitted from Emergency Department within 8 hours. This report will not address immunization rates nor mental health access. While both are topics of great importance to Paediatrics, within the health system these matters are addressed

Department of Paediatrics | Annual Report 2012

Annual Report 2012 | Department of Paediatrics

primarily by Public Health (immunizations) and Mental Health (mental health access). The following summarizes ACH ED activity measures. Note that the ACH ED is the 4th busiest ED in Alberta (after Northern Lights Regional Health Centre, RGH and PLC).

Provincial Target 2011/12

Provincial Average 2011/2012

ACH 2011/2012

Provincial Average 2012/2013 Q1

Discharge in 4 hrs (16 larger EDS)

75%

62%

79%

Discharge in 4 hrs (all EDS)

84%

74%

Admitted from ED in 8 hrs (15 larger EDs)

60%

Admitted from ED in 8 hrs (all EDs)

65%

Measure

ACH 2012/13 Q1

ACH 2012/13 Q2

63%

86%

88%

79%

75%

86%

88%

44%

71%

49%

78%

74%

46%

71%

50%

78%

74%

Photo courtesy of the Alberta Children’s Hospital Foundation

Department of Paediatrics | Annual Report 2012

Alberta Children’s Hospital In 2011, after broad consultation within the hospital, the “Alberta Children’s Hospital Strategic Priorities (2011 – 2016)” document was produced. The following six priorities were defined. 1. Access to Care • New care models and pathways, aligned with clinical networks.

• Review of role and mandate of ED. 2. Care of Complex Patients • New care models and pathways will combined case management and interdisciplinary care. • Improved accessibility of patient information. • New approached to transitional care

Annual Report 2012 | Department of Paediatrics

3. Tertiary Care • Primary focus on acutely ill children. • Emphasis on clinical service development. • Resources will be based on specific needs and demands and will be linked to outreach and the community. 4. Research • Research is fundamentally important to the advancement of knowledge, support of learning and development of best clinical practices and will be emphasized at ACH. 5. Workforce • Maintain engaged workforce through educational strategies and opportunities and in collaboration with post-secondary institutions. • Demonstrate values of physicians, staff and volunteers through definite actions. 6. Image • Maintain and enhance image of ACH through support for research and education, in the pursuit of best practice and excellence in care.

Alberta Children’s Hospital Research Institute (ACHRI) & University of Calgary The Faculty of Medicine developed research priorities in 2009. “Child Health” was determined to be the fourth most important priority. ACHRI is the research institute that most members of the Department of Paediatrics are primarily aligned with. The 2011 ACHRI Strategic Summary reiterated ACHRI’s vision –

“healthy babies, healthy children and youth, healthy lives,” and mission – “to develop as a centre of excellence in maternal, fetal, newborn, child and youth health research and education.” ACHRI has three specific themes: • Behaviour and the Developing Brain. • Healthy Living & Optimizing Health Outcomes. • Molecular & Genetic Basis of Child & Maternal Health. ACHRI has three specific research platforms identified for investment and development: • Functional Imaging. • Clinical, Population and Health Services Research Infrastructure. • Basic and Applied Human Genetics.

Alberta Children’s Hospital Foundation The ACHF has supported clinical services, education and research related to ACH since 1957. The ACHF has specifically and generously supported the Department of Paediatrics in all of these activities. The strategic funding priorities for the ACHF include: • Childhood Cancer. • The Brain – Childhood Neurosciences and Mental Health. • Care for our Sickest Children. • Family Centred Care.

Photo courtesy of the Alberta Children’s Hospital Foundation

Department of Paediatrics | Annual Report 2012

Annual Report 2012 | Department of Paediatrics

Special Feature

ACH Neonatal Intensive Care Unit (NICU) In July 2011, the NICU at the Alberta Children’s Hospital (ACH) became the newest addition to the Section of Neonatal and Perinatal Medicine in the Department of Paediatrics in the Calgary Zone. Opening in borrowed space in the ACH within the Paediatric Intensive Care Unit, the temporary 8 bed level III NICU has provided specialized care for preterm and term newborns requiring cardiac and surgical care, as well as much needed additional level III NICU beds in Southern Alberta.

Infants requiring surgery are transferred to ACH, and remain in the NICU postoperatively to recover and to be monitored by their surgeons and the neonatologists for many weeks. Infants transferred to Edmonton for heart surgery are transferred back to the ACH NICU after a short post operative phase, in order to be close to home and to their cardiologist for follow up care. In addition, newborns requiring complex care involving many specialists and/ or many investigations are frequently cared for in the ACH NICU. Opening a new unit and a new service that had never been offered at the ACH was an exciting opportunity for all involved. The past year has been an exciting one as the NICU patients and staff have been given a warm welcome by the ACH Team. This project has meant finding new ways of doing things, building new relationships and providing neonatal care in new kind of environment. Thanks to a generous donation made by the Murray and Heather Edwards family in 2011, and funding from Alberta Health Services, a new permanent 14 bed Level III NICU is under construction on the 4th floor of the ACH. 2012 has been an exciting year as the new NICU has been planned, incorporating input from past families, NICU team users, the donors, ACH staff and AHS. This project is slated to be completed and open its doors for care late in 2013. This NICU will incorporate the most recent standards for Neonatal Care Environments put out by the Consensus committee on Recommended

Planning

Design Standards for Advanced Neonatal Care. The unit will be made up of 14 private care Neonatal rooms, designed to house a baby with their family. Also incorporated in the space will be a family lounge, teaching space and a separate private quiet room. This new NICU will provide strong support for families struggling with a sick baby, putting those neonates and their parents closer to the specialists needed for their care .

Patient Neighbourhoods

Department of Paediatrics | Annual Report 2012

Overview of Clinical Sections and Divisions, and Research Units Division of Adolescent Medicine

new programs to be designed, and established ones to grow in capacity.

Highlights

Launch of the first Canadian Ronald MacDonald Care Mobile to provide care to underserviced children and families in the SE quadrant of Calgary. Dr. April Elliott was on the committee for the last 4 years, preparing a business plan and seeing the project through to the launch.

Adolescent Medicine programs continue to develop and flourish and this year was no exception. We were very pleased to have a new, third Adolescent physician come in November 2011, and this increase in FTE has allowed for

Clinical Care

Annual Report 2012 | Department of Paediatrics

An Adolescent COPE has been established: involved 6 months of planning with Multisectorial representation our Adolescent Physician (Dr. Jorge Pinzon) and Ruth Wadman were the lead health care providers. Education Collaboration with other subspecialties to organize and host the first Transition Symposium at ACH Nov. 21st, 2012 Evaluation coordinator for course 6 in Undergraduate Medical Education Program (UME) with the Faculty of Medicine at U of C. Date of appointment July 2009 to June 2013. Research Confidentiality Survey was done amongst health care workers at ACH and results have been used to present at numerous conferences, prepare a poster and in the process of being submitted for publication. Will inform future education initiatives and policy around confidentiality. Service to Society CATS clinic team continue to be involved in events outside of the regular work of the clinic including Thanksgiving and Christmas dinners for the homeless population.

Physician/Faculty Listing Dr. April Elliott* – Division Chief Dr. Jorge Pinzon* Dr. Ellie Vyver * * Paediatric AARP Members

Clinical Services Provided • Inpatient and Emergency Outpatient Consultation and Admitting Services for Adolescent Medicine Issues

• Ambulatory Clinics and Services ·· Eating Disorders Program: (outpatient, day program, and inpatient unit) ·· Youth Health Program (R. Wadman Clinical Nurse Specialist 1.0 FTE). The program is located at the Child Development Centre and provides referral and medical consultation services for adolescents, youth and their families. The purpose of this service is to offer consultation to health care providers working with youth with complex medical issues and also to facilitate transition through adolescence for youth with Special Health Care Needs (SHCN) that might have an impact on their development. ·· Additional two clinic days were added with Dr. Ellie Vyver • Outreach Project: Innovative partnership with Department of Paediatrics and Wood’s Homes, EXIT Outreach , Child and Adolescent Mental Health

·· Calgary Adolescent Treatment

Services: (CATS) CATS provides comprehensive, confidential health care, including but not limited to general health care, sexual health care (contraception, STI’s, options counseling), substance use assessment, and mental health evaluation and referral. The CATS clinic welcomes referrals from acute care facilities, family physicians, public health nurses, social workers and other services that work closely with youth-at-risk.

·· COPE: New Jr. High program involving Adolescent Medicine.

Department of Paediatrics | Annual Report 2012

Annual Report 2012 | Department of Paediatrics

Special Feature

The Calgary Adolescent Treatment Services (C.A.T.S) Clinic The Calgary Adolescent Treatment Services (C.A.T.S) Clinic provides street connected youth with comprehensive medical care. The CATS team of Dr. April Elliott, Dr. Jorge Pinzon and Dr. Ellie Vyver, and nurses Ruth Wadman, Judy Bishop , Maura McElligott, and Sherry Pelensky provide youth between the ages of 12-23, who have had limited or inconsistent medical care, with unique access to medical assessment, treatment and plans for longer term physical and mental health follow-up. Many of these youth are homeless and may be living in temporary youth shelters, many of whom would forgo healthcare (until it was an absolute emergency) if this clinic was not available. It not only addresses the medical (physical) concerns of the patients/clients but also supports and finds referrals for many other determinants of health such as emotional health, housing, and education, just to name a few. This population’s medical needs are addressed by providing an appealing and accessible medical service that is oriented to the context in which these youth live. By engaging with this population, this service also attempts to link these youth to a network of family physicians and community providers interested in establishing long-term patient/provider

relationships with these youth. We are very excited to share that the clinic celebrated its 5-year anniversary in 2012. It started operation on February 27th, 2007,for one day/week and was expanded to two days/ week in January of 2010 with the addition of Dr. Jorge Pinzon. Prior to Dr. Pinzon’s arrival we were able to see 140 to 178 patient encounters in the 2008 and 2009 years respectively. With two clinics a week, we’ve increased our clinic time by 60% and our patient encounters by 120% by seeing 310 patient encounters in 2010. In December 2011 Dr. Ellie Vyver joined the CATS team, and attends a third clinic day that runs on Mondays. CATS works in partnership with the staff at Wood’s EXIT outreach to wrap around our patient/client population and try to limit the numerous barriers that our health care system can sometimes present. We have also had support from the Department of Psychiatry with a 0.1 FTE mental health worker from Child and Adolescent Health. This position is critical as a majority of our population has a mental health condition that requires therapeutic support and referral to outside resources. We will continue to strive for gold standard care in 2013 and our next main goal will be to focus our efforts on establishing a formal relationship with Obstetrics and Gynecology to provide comprehensive care for our young pregnant patients.

Department of Paediatrics | Annual Report 2012

Section of Cardiology Highlights – Clinical Care, Education, Research and Service to Society • Participated in successful implementation of ECMO cannulation program. • Started Targeted Neonatal Echo training program. • Dr. Fruitman appointed paediatric residency program co-director. • Recruited Dr. Steven Greenway who brings expertise in paediatric heart transplantation and cardiac genomics.

Physician/Faculty Listing Dr. Frank Dicke* - Section Chief Dr. Robin Clegg* Dr. James Coe Dr. Derek Exner Dr. Deb Fruitman* Dr. Michael Giuffre Dr. Joyce Harder* Dr. Kim Myers* Dr. David Patton* * Paediatric AARP Members

Clinical Services Provided • 24/7 Inpatient and Emergency Outpatient Consultation and Admitting Services • Ambulatory Clinics and Services ·· Cardiology Clinic ·· Paediatric Heart Transplant Clinic ·· Pacemaker Clinic ·· Arrhythmia Clinic ·· Exercise Stress Testing, Holter and ECG ·· Invasive Cardiac Services including diagnostic and limited

Annual Report 2012 | Department of Paediatrics

interventional cardiac catheterization, transesophageal EP and Echo, EP study/ablation ·· Congenital Cardiac Imaging including MRI, CT, 3-D Echo, 2-D Echo • Outreach ·· Lethbridge ·· Medicine Hat ·· Morley çç Fetal Cardiology Clinic at Maternal Fetal Medicine çç Adult Congenital Heart Clinic çç Adult Congenital Arrhythmia Clinic çç Congenital MRI support at Stephenson MR Centre

Section of Community Paediatrics Highlights – Clinical Care, Education, Research and Service to Society • Annual Networking Event Kananaskis (September): this is a very popular and successful function and brings together and brings together paediatricians from across southern Alberta. This year’s topic was “Sleep Disorders in Childhood” and featured local and invited speakers. • Family Practice Resident Ambulatory Care Experiences (ACEs): SCP has partnered with the Department of Family Medicine to provide clinical exposure and teaching in community office settings. This identified gap in the resident experience has been very effectively addressed through this program and has been identified as a very valuable learning experience.

• Urgent Consultation Service: SCP provides urgent consultation services for acutely ill children who have recently been seen in Calgary ERs or recently discharged from an acute care site. Children are thereby able to access community specialist assessment within 72 hours of an ER visit or hospital discharge. This service is centrally coordinated and participating physicians ensure that appointment slots are held open in anticipation of urgent referrals.

Physician/Faculty Listing Dr. Stephen Wainer- Section Chief* Dr. Kelleigh Klym- PLC Site Chief* Dr. Christopher Lever- FMC Site Chief Dr. Darrell Palmer- RGH Site Chief Dr. Jennifer Macpherson- PGME Program Director* Dr. Susan Aitken Dr. Hilda Angeles Dr. Rachel Bond Dr. Starr Cardwell Dr. Nathaniel Chan Dr. Neil Cooper - Lead Child Abuse Program Physician Dr. Kate Culman Dr. Alfred Dei-Baning* Dr. Amanda Evans Dr. Kristin Evashuk Dr. Natalie Forbes Dr. Frank Friesen Dr. Roxanne Goldade* Dr. Sivalingum Govender Dr. Janice Heard Dr. Hardally Hegde Dr. Della Ho* Dr. Keith Jorgenson Dr. Michele Kalny Dr. Cham-Pion Kao Dr. Lori Kardal Dr. Suba Karthikeyan Dr. Brian Kelly Dr. Victoria Kendrick

Dr. Alexander Leung Dr. Roderick Mackenzie Dr. Donald Markowsky Dr. Kathleen Mitchell Dr. Danielle Nelson Dr. Jane Ng Dr. Peter Nieman Dr. Steven Olliver Dr. Lane Racher Dr. Swait Rastogi Dr. Lauren Redgate Dr. Lioba Redel Dr. Novak Michele Dr. Daniel Ross Dr. Heidemarie Schroter* Dr. Elizabeth Shyleyko Dr. Cheri Stanzeleit Dr. Pamela Stone Dr. Tracy Taylor Dr. David Truscott Dr. Byron Wong Dr. Monique Wright Dr. John Wu Dr. Douglas Yeung *Supported by Pediatric AARP

Clinical Services Provided • 24/7 Inpatient and Emergency Outpatient Consultation and Admitting Services ·· Preceptor Program (Peter Lougheed Centre) ·· Well-baby nurseries (all sites) ·· Special Care Nurseries (all sites) ·· Hospitalist Program (ACH) • Ambulatory Clinics and Services ·· Approximately 14 community paediatric office locations throughout Calgary ranging from solo to large multi-specialty practices. ·· Multiple SCP members participate in ambulatory sub-specialty clinics at ACH (Asthma, Child Abuse, Head Shape, Vascular Malformation and other).

Department of Paediatrics | Annual Report 2012

• Outreach ·· Morley Reserve ·· Tsuu T'ina Reserve ·· Refugee Clinic ·· CUPS Clinic ·· Collaborative Mental Health Program (East Calgary Health Centre) ·· Developmental and Behavioural Clinic (East Calgary Health Centre) ·· Community Outreach of Paediatrics and Psychiatry in Education program (COPE) (multiple physicians) ·· Paedatrics for Kids in Care (P-KIC) program (multiple physicians) ·· PaedLink Telephone Consultation Service (multiple physicians) ·· Paediatric Urgent Consultation Service (multiple physicians) ·· Transcutaneous Bilirubinometry program (PLC call group)

Section of Critical Care Highlights – Clinical Care, Education, Research and Service to Society In 2012 the PICU managed 956 admissions, with an overall mortality of 2.7%. Average length of stay was 3.73 days. Approximately 50% of admission receive invasive mechanical ventilation and another 1/3 non-invasive ventilation, totaling 2,526 hours of ventilatory support provided per year. The new programs providing Extracorporeal Life Support, Transport and STEP have been highly successful: • ECLS: ECLS activations – 20, ECLS cannulations – 9, ECLS survivors - 7, with only one moderately disabled survivor

Dr. Jonathan Gamble* Dr. Elyahu Gilad* Dr. Elaine Gilfoyle* Dr. Jeremy Luntley Dr. Meagan Mahoney* Dr. Barbara Catherine Ross* Dr. Terry Stewart *Critical Care Clinical ARP Members

Clinical Services Provided

Dr. Simon Parsons*- Section Chief Dr. Kathleen Tobler*- PGME Program Director Dr. Jaime Blackwood* Dr. Shauna Burkholder* Dr. Robin Cox Dr. Tanya Drews*

• Accredited fellowship program: first trained fellow Developmental Paediatrics (2012)

• Section receives the largest number of paediatric residents annually (a minimum of 2 residents per month/year)

Clinical

Physician/Faculty Listing

• Numerous teaching activities at the University of Calgary, Faculty of Medicine

Section of Developmental Paediatrics

• STEP: Calls – 324, Follow-Ups - 257

Dr. Jaime Blackwood received the Sam Darwish Resident Teaching Award 2012.

In concordance with the mission of the Department, our section is involved in many important education activities.

• Paediatric practical course for Family Physician at the University of Calgary, Faculty of Medicine organized by one member of the section (over 90 attendees)

Highlights – Clinical Care, Education, Research and Service to Society

Progress has been made towards implementation of eCritical (computerized nursing recording) and the development of a PICU database through Virtual PICU Systems in USA.

Education

24/7 Inpatient and Emergency Outpatient Consultation and Admitting Services

• Transport: Interhospital Transports – 185, Intrahospital Transports – 108

The PICU has developed an extensive set of Clinical Practice Guidelines that are being widely used offering better consistency and care and better outcomes.

Annual Report 2012 | Department of Paediatrics

In order to continue delivering high quality of care , our section has done the following: • Recruitment of a full-time neurologist specializing in neurodevelopmental problems • Participation in the ACE-II Project (AHS) ·· Changes made to improve intake wait time and delivering process ·· Changes to referral process ·· Redesign and refinement Central Intake process ·· Revised inclusion/exclusion criteria for all clinics ·· Revised Child Development Services organizational and service chart Of note: The Child Development Services (CDS) at the Child Development Centre (CDC) celebrated their 5th year existence

• Numerous presentations and courses done locally, nationally and internationally • Participation PhD Master Science Committee Research • Grants received by numerous section members in the following fields: ·· International Health (Haiti, Dominican Republic) ·· Medical Education ·· Developmental Coordination Disorder (DCD) ·· Child Development Problems (ASD, ADHD) ·· Developmental Screening in Primary Care ·· Use of antipsychotics (monitoric, effectiveness and safety) ·· Collaborative Mental Health Services • Research supervision of several students within the Bachelor of Health Sciences program as well as Paediatric PostGraduate programs

Department of Paediatrics | Annual Report 2012

Awards/Promotion Awarded Founder status from the Royal College of Physicians and Surgeons of Canada • Dr. Jean-François Lemay • Dr. Pamela Veale • Dr. Ben Gibbard Promotions • Appointment to Professor (University of Calgary) - Dr. Jean-Francois Lemay • Appointment to Associate Professor - Dr. Pamela Veale

Physician/Faculty Listing Dr. Jean-Francois Lemay * - Section Chief Dr. Ben Gibbard*- PGME Program Director Dr. Jennifer Fisher* Dr. John McLennan* Dr. Alison Moore* Dr. Ted Prince* Dr. Heidi Schroter* Dr. Pam Veale* *Paediatric AARP Members

Annual Report 2012 | Department of Paediatrics

Clinical Services Provided • Our section does not offer 24/7 Inpatient or Admitting Services. However we are offering On-call and Emergency Outpatient Consultation services if required. Also consultation to Child Abuse Services is provided when needed. • Ambulatory Clinics and Services offered at the Child Development Centre through Child Development Services (CDS) ·· Developmental Paediatrics Clinics (DPC) ·· Developmental Psychiatry Consultation Service (DPCS) ·· Consultative Clinics (Phone) for Community Paediatricians

Section of Emergency Medicine Highlights – Clinical Care, Education, Research and Service to Society Delivering high quality evidence-based clinical care • Annual census of 65,000 ED visits • 82% of all paediatric ED visits in Calgary are seen at ACH • Highest percentage of patient care within the 4 hour ED length of stay targets in Calgary Zone

·· Neuro-developmental Clinics

• Continuous innovation in patient care strategies for efficient clinical care

·· Child Development Medication Assessment Services (CD-MAS)

• Leaders in regional/provincial/national clinical care pathway development

·· Fetal Alcohol Spectrum Disorders Clinics (FASD) • Outreach Clinics: ·· Strathmore (AB) ·· High River (AB) ·· Northern and Southern Alberta Francophone Services (AB) • COPE (school-based services) in Calgary and suburbs through school boards (COPE is a unique collaborative approach and outreach to schools and how teachers are uniquely placed to identify children with developmental and psychiatric problems thus ensuring interventions can be made that otherwise may not be).

• HPS Outreach acute care paediatrics to community partners in their local setting ·· 15-20 rural and regional centres per year ·· Over 400 health care professionals per year • PALS (Paediatric Advanced Life Support) Training and certification courses • PEACH - Hosted 1stPaediatric Emergency Medicine CME Conference ·· Paediatric Emergencies Alberta Children’s Hospital in March 2012 ·· 120 community physicians and nurses attended from across Alberta and western Canada and internationally ·· Nominated for Best New CME of 2012 event by CFPC

·· Asthma, Gastroenteritis, Appendicitis, Status Epilepticus • Paediatric Critical Care Transport Team involvement and leadership Training caregivers at all levels • Paediatric Emergency Medicine Training Program (2011/12):

Photo courtesy of the Alberta Children’s Hospital Foundation

·· PEM Fellowship: 6 PEM subspecialty trainees - 3 PEM fellowship trainees per year ·· 124 Mandatory rotations for residents from other programs ·· 68 Clinical Clerks UofC ·· 15 Visiting Learners • Human Patient Simulation ·· Allied health professionals (RN and RRT) ·· All levels of medical trainees (UME, PGME, Fellowship) ·· HPS leaders at ACH, U of C and provincially (Dr. Vince Grant)

Department of Paediatrics | Annual Report 2012

Innovation and Dissemination of new knowledge *Dr. Antonia Stang – Terry Klassen Young Investigator Award – PERC 2012* ACH clinician scientists and educators are national and international leaders at: 1. Generating best evidence for the care of severely ill and injured children, • The Implementation and Evaluation of an Alberta Childhood Asthma Clinical Pathway 2. Determining the best ways to teach health care professionals to incorporate new knowledge into their practice, • Knowledge Translation Canada: A National Research Network • Translating Emergency Knowledge for Kids (TREKK) 3. Developing educational programs using Human Patient Simulation that provide clinicians thenecessary skills and confidence to care for these children, and • Assessing and Improving the Quality of Cardiopulmonary Resuscitation (CPR) 4. Developing tools known as clinical indicators for determining if severely ill and injured children receive optimal care. • The Development of Quality Indicators for High Acuity Paediatric Conditions Requiring Emergency Care

Physician/Faculty Listing Section Chief: Dr. Angelo Mikrogianakis* PGME Program Director: Dr. Kelly Millar* Dr. Michele Bjornson Dr. Francois Belanger* Dr. Gavin Burgess Dr. David Chaulk Dr. Adam Cheng*

Dr. Anthony Crocco Dr. Jenn D’Mello Dr. Stephen Freedman* Dr. Roger Galbraith* Dr. Jennifer Graham Dr. Vince Grant* Dr. Jonathan Guilfoyle Dr. Carey Johnson Dr. David Johnson* Dr. Kristen Johnson Dr. Christine Kennedy Dr. Tanuja Kodeeswaran Dr. Kerri Landry Dr. Ed Les* – ACH Clinical Lead Dr. Patrick Milhalicz* Dr. Cheri Nijssen-Jordan Dr. Lisa Odendal Dr. Mary-Louise O'byrne Dr. Katharine Smart Dr. Derrick Smith Dr. Antonia Stang* Dr. Izabela Sztukowski Dr. Graham Thompson* - Acting PGME Program Director Dr. Margaret Thomson Dr. Jennifer Thull-Freedman* Dr. Hussein Unwala Dr. Donald Bethune Dr. Mark Bromley Dr. Andrea Boone Dr. Shawn Dowling Dr. Marc Francis Dr. Jeffrey Grant Dr. Jason Green Dr. Kevin Johnson Dr. Verna Krisik Dr. Lorraine Mabon Dr. Gordon Mcneil Dr. Andre Michalchuk Dr. Sarah McPherson Dr. Adam Oster Dr. Philip Ukrainetz Dr. Ian Wishart Dr. Bryan Young

Annual Report 2012 | Department of Paediatrics

Clinical Services Provided • 24/7 Inpatient and Emergency Outpatient Consultation and Admitting Services • Ambulatory Clinics and Services ·· Emergency ·· Paediatric Critical Care Transport Team supervision and education • Outreach

·· HPS Outreach education çç 15-20 rural and regional sites per year çç 400 health care professionals per year ·· Rural EM CME lectures ·· Urgent Care CME lectures PALS courses (5-6 per year)

Photo courtesy of the Alberta Children’s Hospital

*Paediatric AARP Members

DEPARTMENT OF PAEDIATRICS | AnnUAl RePoRt 2012

AnnUAl RePoRt 2012 | DEPARTMENT OF PAEDIATRICS

SPeCIAl FeATure

PEACH Conference The concept for the PeACH (Paediatric emergencies Alberta Children’s Hospital) Conference began as a mere conversation between a small group of individuals. After 18 months of planning, the PeACH PAlS pre-conference on March 7-8, 2012 and the PeACH conference on March 9-10, 2012, turned into an education experience for 80 physicians and 40 allied health care professionals throughout Canada and beyond. Delegates came from as far as Australia and Columbia. PeACH was four days of teaching, learning and interacting with 120 learners and none of it would have been possible without the staff and volunteers who worked tirelessly to make it all possible.

This was an excellent, well organized course. All of the instructors were helpful and organized. 32

The Section of Emergency Medicine in the Department of Paediatrics at the Alberta Children’s Hospital is a leading paediatric center in western Canada. The PEACH conference was an opportunity for delegates to come and learn from leading edge simulation technology run by Canada’s top simulation educators, hands on teaching and a focus on the latest evidence-based medicine.

One of the best and most relevant conferences I have been to.

loved the hands-on scenarios. PEACH went beyond any of the planning committee’s expectations of what they had envisioned for success in both registration numbers and delegate enthusiasm. The positive energy created is credited to the efforts of all the people involved in PEACH. The inaugural PEACH Conference has been nominated for a Continuing Professional Development program award by the College of Family Physicians of Canada. Dr. Mikrogianakis, section chief of the ACH ED and director of PEACH said, “We are very pleased with all of the positive comments from our delegates. This type of positive feedback comes because of the time, commitment and thought all the staff put into planning PEACH." The PEACH Conference is scheduled to take place again on March 8-9, 2013. Photo courtesy of the Alberta Children’s Hospital Foundation.

Department of Paediatrics | Annual Report 2012

Section of Endocrinology Highlights – Clinical Care, Education, Research and Service to Society In accordance with the vision, mission and values of the Department of Paediatrics, our section continues to offer compassionate and respectful high quality care, while also having significant involvement and leadership in medical education and research. Clinical Highlights • Inauguration of the Paediatric Center for Weight and Health • In-house survey of diabetes clinic patients and families results showing a very high level of satisfaction with education and follow-up care received in our clinic • Maintenance of high quality specialized and multi-disciplinary care for children with diabetes or endocrine conditions Education Highlights • Provides and supports all undergraduate and post graduate Paediatric training • High quality sub-specialty training program (as confirmed by internal review) • Ongoing allied health professional training for ongoing use of family therapy approach to improve parenting skills for families with a child with diabetes Research Highlights • Dr. Carol Huang received a significant Canadian Diabetes Grant to support her ongoing basic research work on prolactin and placental hormones as adjunct treatment of diabetes • Ongoing participation of our section

Annual Report 2012 | Department of Paediatrics

in international diabetes trials such as TRIGR and TrialNet • Ongoing clinical research initiated locally and involving both staff and trainees Service to Society • Dr. Danièle Pacaud is chair of the Paediatric Chapters for the Canadian Diabetes Association 2013 Clinical Practice Guidelines • Dr. Danièle Pacaud is President-Elect for the Canadian Paediatric Endocrine Group

·· Development of a paediatric weight management clinic (Official Launch 2012) ·· Paediatric Center for Weight and Health: comprehensive approach to the management of children suffering from obesity and co-morbidities • Outreach ·· We provide outreach clinics in paediatric endocrinology and

diabetes to çç Medicine Hat (6 clinics per year), çç Lethbridge (4 clinics per year) and çç Red Deer (4 clinics per year). ·· We also provide shared care for diabetes to Cranbrook through telehealth and alternating medical follow-up.

• Dr. Jonathan Dawrant is Medical Director of Jean Nelson Summer Camp for children with diabetes

Physician/Faculty Listing Dr. Danièle Pacaud*- Section Chief Dr. Jonathan Dawrant*PGME Program Director Dr. Josephine Ho* Dr. Carol Huang* Dr. Rebecca Perry* Dr. David Stephure* *Paediatric AARP Members

Clinical Services Provided • 24/7 Inpatient and Emergency Outpatient Consultation and Admitting Services • Ambulatory Clinics and Services ·· Diabetes Clinic (comprehensive education and follow-up programs providing on going care for over 800 children with diabetes with an average of 110 newly diagnosed patients per year) ·· Endocrinology Clinic (provides consultative services and ongoing care in paediatric endocrinology with over 1700 encounters annually) ·· Paediatric Endocrine testing and interpretation

Department of Paediatrics | Annual Report 2012

Annual Report 2012 | Department of Paediatrics

Section of Gastroenterology

• Posters of Distinction at National and International Meetings – Drs DeBruyn, Wrobel, Soon (fellow)

Highlights – Clinical Care, Education, Research and Service to Society

• Increase in funding for IBD research – national database development, research into new imaging techniques in IBD, optimising treatment, vaccination in immunosuppressed patients – Drs De Bruyn, Wrobel, Waterhouse

Clinical Care • Initiation of Calgary zone automatic direct bilirubin for neonates with jaundice for early detection of liver disease. • Development of Advanced Intestinal Motility Lab - Recruitment of Dr Alfred Yeung and funding for state-of-the art equipment. • Implementation of functional abdominal pain group sessions – K Swartzenberger • Initiation of Lethbridge outreach clinic Education • Members of the section contributed to undergraduate medical education in roles of course chair, bedside and small group teaching, lecturing and clinical mentoring. Our postgraduate subspecialty residency program remains a highlight of our section and underwent a successful internal review this year. Gastroenterology is actively involved in resident and CME lectures. • Regional - Inaugural Western Canadian Paediatric GI Conference – Drs S Martin, I Wrobel • National - our section is represented by Dr L McKenzie as a member of the Royal College Examination Board for Gastroenterology; Dr Martin as Chair, Canadian Association of Gastroenterology annual GI Residents Course. Research • First successful Canadian Liver cell transplantation for metabolic liver disease

Service to Society • Dr. Boctor is member of the Canadian Paediatric Society Nutrition Committee and is active in the Healthy Child Uganda Program

Physician/Faculty Listing Dr. Steven Martin*- Section Chief Dr. Leanna McKenzie* - PGME Program Director Dr. Dana Boctor* Dr. Decker Butzner* Dr. Jennifer DeBruyn* Dr. Helen Machida* Dr. Brent Scott* Dr. Chris Waterhouse* Dr. Iwona Wrobel* Dr. Alfred Yeung* **Paediatric AARP Members

Clinical Services Provided • 24/7 Inpatient and Emergency Outpatient Consultation and Admitting Services ·· Ambulatory Clinics and Services çç Home Nutrition Support Services çç Clinical Nutrition çç Gastroenterology/Hepatology çç Constipation Clinic çç Parenteral Therapy Program çç Feeding Consultation Services çç Off site consultations (Rockyview General Hospital

NICU, Foothills Medical Centre NICU, Peter Lougheed Hospital NICU) çç CHIRP Program çç SAPHEN Program çç Cystic Fibrosis Clinic çç Esophageal Atresia Clinic çç Liver Transplant Clinic çç Elective and Emergent Endoscopy çç GI procedures Lab: (Breath Testing, Motility) ·· Outreach

çç Medicine Hat (5 per year) çç Lethbridge (5 per year)

Section of Hematology (includes data for Division of Allergy/Immunology) Highlights – Clinical Care, Education, Research and Service to Society The past two years have seen continued growth in our patient population, particularly in the area of hemoglobinopathies. Increase in physician staffing has allowed for increased assesement and treatment of patients with primary immune deficiencies as well as the creation of a first Allergy assessment and Challenge clinics at Alberta Children’s Hospital. Clinical Highlights • Creation of Allergy Assessment and Challenge Clinics • Expansion of the Hemoglobinopathy service with a dedicated multidisciplinary team • Top 40 Under 40 Award - Dr. Wright

Education Highlights • Faculty Awards • Gold Star Teaching Award – Dr.Le Research Highlights • Ongoing participation in numerous national clinical trials

Physician/Faculty Listing Hematology Dr. Michael Leaker*- Section Chief, Deputy Department Head Dr. MacGregor Steele*- PGME Program Director Dr. Doan Le* Dr. Nicola Wright* Immunology Dr. Fotini Kavadas* *Paediatric AARP Members

Clinical Services Provided • 24/7 inpatient and Emergency Outpatient Consultation and Admitting Services • Ambulatory Clinics ·· Hematology Clinics ·· Paediatric Bleeding Disorders Clinic ·· Thrombosis Clinic ·· Primary Immune Deficiency Clinic ·· Allergy Assessment Clinic ·· Hemoglobinopathy Clinic • Outreach Services ·· Paediatric Bleeding Disorders Clinic – Lethbridge and Medicine Hat ·· Consultation Services to Adults with Suspected Immune Deficiencies

Department of Paediatrics | Annual Report 2012

Section of Hospital Paediatrics Highlights – Clinical Care, Education, Research and Service to Society Clinical Care Highlights • In addition to the continued attending care for 85% of the medical inpatients at ACH and 24/7 in-house coverage and consulting service, a Paediatric Followup Clinic was successfully piloted in early 2012 and started as an ongoing service in October 2012. The clinic, which runs 3 afternoons a week, enables safe discharge even earlier by providing a paediatric clinic visit to reassess admission-related ongoing issues within 24-48 hours of discharge. The clinic is one of many strategies to aid in reducing capacity pressures at ACH. Dr. Sidd Thakore is the medical lead for the clinic. • In 2012, a Complex Care Nurse Practitioner was hired to join the Complex Care Team: Rachel Williamson, NP has been a welcome addition to Sheena Mainland, CNS in supporting the care of medically complex inpatients along with our complex care hospital paediatricians • The Section 360 evaluation process for 2012 (completed q 3 years) was coordinated by Dr. Gemma Vomiero. This comprehensive feedback process for hospital paediatricians gathers input from families, nurses, trainees, allied health, colleagues and peers. Education Highlights • In recognition of the high quality of education section members provide to a large number of trainees (medical students, PGY-1 residents, paediatric

Annual Report 2012 | Department of Paediatrics

residents) the following education awards were received by our Section members: ·· 2012 Sam Darwish Resident Teaching Award: Dr. Lisa Lemieux ·· Community Paediatrics Resident Teaching Award 2012: Dr. Gary Chow ·· Clerkship Teaching Award for Faculty: Dr. Hani Hadi ·· Gold Star Teaching Award (class of 2012): Dr. Lindsay Long, Dr. Lisa Lemieux • In recognition of her leadership in education, Dr. Susan Bannister was presented the Department of Paediatrics Clinical/Educator Award for 2012 • Dr. Susan Bannister led the creation of canuc-paeds a Canadian Undergraduate Curriculum in Paediatrics in a concise user-friendly format. • In 2012, Dr. Lindsay Long piloted and initiated a new simulation training program called “JIT” which provides “Just-In-Time” simulation of current inpatients who are at highest risk of deterioration. • Dr. Gemma Vomiero provided curriculum development for the Department mentorship program initiated in 2012. Research Highlights • Two new full AARP positions each with dedicated research time were initiated in 2012: one for clinical research (Dr. Chantelle Barnard) and one for educational research (Dr. Preet Sandhu). This is the Sections first dedicated research FTE. The section’s volume of grants and publications are increasing along with continuing academic growth within the Section. • A new research group was created in 2012 to aid in research collaboration and development within the Section.

Service to Society • Dr. Hani Hadi completed a 6 months of medical service for Doctors Without Borders in Sierra Leone from January to June 2012. • Dr. Jenn Brenner continues as Canadian Director of Healthy Child Uganda including securing the necessary ongoing grant funding to continue this vital work and evaluate outcomes.

Physician/Faculty Listing Full AARP positions: Dr. Michelle Bailey Dr. Suzette Cooke Partial AARP positions: Dr. Gemma Vomiero – Deputy Section Chief Dr. Susan Bannister Dr. Julie Fisher Dr. Preet Sandhu Dr. Lori Walker Dr. Sarah Hall Dr. Chantelle Barnard Dr. Aaliya Sabir Dr. Hani Hadi Dr. Jenn Brenner Dr. Lindsay Long Dr. Gary Chow Dr. Laura Davies Dr. Dominique Eustace Dr. Barbara Grueger Dr. Renee Jackson Dr. Quyen Lam Dr. Lisa Lemieux Dr. Catherine Macneil Dr. Cristina Stoian Dr. Sidd Thakore Dr. Mike Vila Dr. Chris Andrews Dr. Michelle Jackman

Clinical Services Provided • Admitting and Attending Physician Services for 85% of medical inpatients (daytime inpatient attending services provided by 4-5 inpatient Attending Teams – two teaching teams, one complex care team, one rehabilitation/ general paediatrics team, one general paediatrics team during seasonal demands; • Daytime admitting service for peak admission season. • Overnight coverage for all Hospital Paediatrics teams/services by an inhouse Hospital Paediatrician. • 24/7 Inpatient General Paediatrics Consultation. • 24/7 Code Team Leader (for Code Blue outside of ICU, ED, NICU and OR). • Ambulatory Clinics and Services – Follow-up Clinic to facilitate early discharge from ACH: pilot in early 2012 followed by full clinic initiation in fall 2012; clinic runs 3 afternoons per week.

Part Time: Dr. Melissa Gross Dr. Kevin Levere Dr. Mary Fras – locum

Department of Paediatrics | Annual Report 2012

Section of Infectious Diseases Highlights – Clinical Care, Education, Research and Service to Society Clinical Care • Increase in institutional hand washing rates from 50% to 75%; ACH now has the highest rate in the province. Achieved through the efforts of the Hand Hygiene

Annual Report 2012 | Department of Paediatrics

Committee and Dr. Joseph Vayalumkal, Medical Officer, Infection Prevention and Control. • Collaboration with other Sections to develop guidelines for management of bacterial meningitis, urinary tract infections, empyema, and oncology/BMT care during respiratory virus season. • Facilitation of early discharges and diversion of admissions to outpatient parenteral services through the ambulatory and home parenteral therapy programs.

Education • Development of a mini-course in paediatric ID for undergraduate medical students • Successful Internal Review of the Infectious Diseases Residency Training Program • 2 PGME trainees in 2011-12, 3 PGME trainees in 2012-13 • Supervision / committee members for several graduate students • Annual Paediatric ID Conference in Banff, directed by Dr. Taj Jadavji • Creation of “Volunteers for Infection Prevention”, collaborating with volunteer services to educate patients and their families in infection prevention measures to maximize their protection while hospitalized. Research • The ACHIEVE (Alberta Children’s Hospital Infectious Diseases Epidemiology and Vaccine Evaluation) Research Team continues to be productive with an ever-expanding array of research evaluating influenza, 13-valent pneumococcal conjugate, and meningitis vaccines. Epidemiologic studies of vaccine preventable diseases particularly pneumococcal disease continue. • Section members continue to develop productive working relationships with researchers in immunology/ ID, engineering and psychology/ education along with public health, the microbiology laboratory, and other Sections such as GI. A novel example of such collaborations includes a study of the interaction of children with a robot used for distraction during influenza immunization.

• Members are active participants in national surveillance programs such as Immunization Monitoring Program – ACTive (IMPACT), the Canadian Nosocomial Infection Surveillance Program (CNISP), and Public Health Agency of Canada/Canadian Institutes of Health Research Influenza Research Network (PCIRN). Service to Society • Dr. Jadavji is a member of the Board of “Make a Wish Foundation”

Physician/Faculty Listing Dr. Susan Kuhn*- Section Chief Dr. Rupesh Chawla*- PGME Program Director Dr. Taj Jadavji* Dr. James Kellner*- Department Head Dr. Mireille LeMay* Dr. Otto Vanderkooi* Dr. Joseph Vayalumkal* *Paediatric AARP Members

Clinical Services Provided • 24/7 Inpatient and Emergency Outpatient Consultation and Admitting Services • Ambulatory Clinics and Services ·· Ambulatory Parenteral Therapy Program (APTP) Clinic ·· Home Parenteral Therapy Program (HPTP) ·· Infectious Disease Clinic ·· International Adoption Clinic ·· Tropical Medicine Clinic ·· Perinatal HIV Clinic (at Southern Alberta Clinic) • Phone Consultation Services • Infection Prevention and Control

Department of Paediatrics | Annual Report 2012

Section of Medical Genetics Highlights – Clinical Care, Education, Research and Service to Society • Dr. Aneal Khan led a multidisciplinary team at ACH who successfully performed Canada’s first liver cell infusion therapy for patients with Urea Cycle disorders. These are a devastating group of metabolic conditions that result in the accumulation of neurotoxic ammonia. The first liver cell transplantation was successfully performed on a young 3-month-old patient from Winnipeg. ACH will very likely remain as the only Canadian centre to perform this treatment. Our metabolic clinic is developing a significant program in novel therapeutics and in 2013 we anticipate performing ACH’s first gene therapy treatment for Fabry disease. (Picture included with Dr. Khan and Family) • Initially funded in 2011, FORGE Canada is a large multicentre effort to identify

Annual Report 2012 | Department of Paediatrics

genes for rare disorders using next generation sequencing approaches. Our clinic is one of the largest contributors to FORGE Canada with dozens of active projects. One of these, led by Dr Bernier, identified the gene for Nager syndrome in 2012 and further successes anticipated in 2013. • We partnered with paediatric neurology to host a Tuberous Sclerosis workshop with invited international experts. This event was supported by generous donations from community fundraising. We continue to be supported by our community and families and their efforts are greatly appreciated. • Dr. Michael Innes was named National Coordinator to Orphanet: an international organization whose aim is to improve the diagnosis, care and treatment of patients with rare diseases. This appointment reflects his reputation nationally for his expertise in rare disorders.

patients and patients from South Eastern British Columbia. The clinic has grown to one of the largest in Canada and provides both general as well as subspecialty clinic services to over 6000 patients and families a year. • 24/7 Inpatient and Emergency Outpatient Consultation and Admitting Services • Ambulatory Clinics and Services ·· Genetics çç Paediatric dysmorphology çç General Genetics çç Prenatal genetics çç Cancer Genetics

çç Neurogenetics çç Ophthalmic Genetics çç Cardiogenetics çç Connective Tissue Disorders ·· Metabolic Disease Clinic çç General Metabolic Clinic çç Lysosomal storage disorders çç Mitochondrial Disorders çç Phenylketonuria Clinics ·· Outreach çç Outreach clinics occur on a monthly basis in Medicine Hat, Lethbridge and Red Deer.

Photo by: Paul Rotzinger

Physician/Faculty Listing Dr. Francois Bernier *– Section Chief Dr. Mary Ann Thomas* - PGME Program Director Dr. Robin Casey* Dr. Patrick Ferreira* Dr. Michael Innes* Dr. Aneal Khan* Dr. Julie Lauzon* Dr. Brian Lowry * Dr. Ross Mcleod* Dr. Renee Perrier* Dr. Rebecca Sparkes* *Paediatric AARP Members

Clinical Services Provided

Photo by: Paul Rotzinger

The section provides comprehensive clinical genetics and metabolic clinical services for Southern Alberta. The metabolic group also acts a referral service for Saskatchewan

Department of Paediatrics | Annual Report 2012

Section of Neonatology Highlights – Clinical Care, Education, Research and Service to Society Clinical Care • Efforts to increase breast milk feeding has resulted in a decrease in the incidence of NEC amongst the most premature infants from 13.6% to 4.8 %. • Within a year of implementing targeted practice changes, the incidence of BPD/ CLD has been reduced by 50%; parallel decrease in patient oxygen days, number of patient ventilator days and discharges on home oxygen. • Percutaneous Central Vascular Catheter program; 47 placements outside of FMC where program resides. • Transports: 236 incoming, 215 in-house, 153 out-going to level III, and 529 outgoing to level II/I. • Collaborated with RAAPID to improve transfers of sick newborns and high risk laboring women. • Neonatal Quality Improvement: 4 projects completed, 5 on-going surveillance projects, 8 on-going audits. • Coordinating Committee: drafted/ approved 9 clinical protocols; presently developing 10 clinical protocols. • Established Neonatal Functional Echo in collaboration with cardiology. • Early stages of establishing Neonatal Neuro-monitoring • There were no safety reviews requested or performed in 2011/12. 20 neonatal mortality reviews. • NPNC: 25 drug Monographs reviewed • Electronic Health Record: Dr Rabi led significant improvements in content and function of the neonatal EHR System.

Education • CME: 28 Neonatal Grand Rounds, 2 workshops, 19 Clinical/neuroradiology Rounds, 2 Journal Clubs. • Neonatal Perinatal Medicine: 14 residents completed 2 case reports, 5 retrospective studies, 2 reviews, and presently there are 10 retrospective, 2 prospective, and 3 QI projects on-going. • 46 Paediatric residents, 28 U of C Clinical Clerks, and 11 Clerks from other Universities rotated in Neonatology. • Responsible for Well Baby Exam, Neo small group sessions, Course VI, and Ped.-Neo clerkship teaching. Research • 20 principle research grants, $ 1,343,087, 17 Co-investigator grants, $ 28,536,590, 4 unfunded projects, and 33 ongoing research projects. • 41 peer reviewed articles and 26 abstracts.

Annual Report 2012 | Department of Paediatrics

• Dr. Shabih Hasan is a Doctoral Examiner for Institute of Medical Sciences and School of Pharmacy, University of Toronto.

early results showing reduced neonatal mortality/stillbirth rate; she is technical advisor for Bangladesh and Uganda for HBB.

• Dr. Alixe Howlett contributes as an examiner for RCPSC and National OSCE for neonatal perinatal medicine.

• Dr. Singhal is Associate Editor for the 2012 Global effort, "Essential Newborn Care" to be launched in 2013.

• Dr. Abhay Lodha is a Reviewer of workshops and abstracts for PAS and Western Perinatal Society annual meeting.

• Dr. Singhal is Co-Chair of the Neonatal ILCOR working group tasked to produce resuscitation guidelines for newborns in resource limited settings and participant in WHO research priorities in resource limited settings.

• Dr. Reg Sauve contributes to the Institute Advisory Board and Clinical Research Review Panel of the CIHR. • Dr. Amuchou Soraisham contributes to EPIQ Literature Review Committee of CNN. • Dr. Nalini Singhal is Ass. Editor/ Education evaluator for the 2011 Global effort, "Helping Babies Breathe (HBB)", now taught in over 50 countries and

• Dr. Singhal is the U of C technical team lead, for the Uganda Community Health Strategies 3 year project. • Dr. Kamaluddeen participated in the Canada-China Neonatologist educational program. • Dr. Carlos Fajardo coordinated the SIBEN Neonatal Network report, 2011; for the

Service to Society • Dr. Albert Akierman received a 2012 Recognition Award for Education and Patient Care in Alberta. • Dr. Anne Tierney Co-Chairs/Neonatal Consultant for the APH Program for Perinatal mortality reviews. • Dr. Hasan contributed to the PACT and PTC Committees, to its 10 year Alberta Tobacco Reduction Strategy. • Dr. Rabi is leading the development of new technology to guide oxygen management in the delivery room. National/International Work • Dr. Harish Amin contributes to the RCPSC and the Global Paediatric Education Consortium. • Dr. Jill Boulton contributed to the updating of the ACoRN 2012 publication.

Department of Paediatrics | Annual Report 2012

19 participating NICUs in Iberoamerica. He organized and present a workshop in Neonatal Network, SIBEN Conference

• Dr. Fajardo organized a videoconference on HIE/Hypothermia in collaboration with Dr. Harvey Sarnat and Dr. Laura Sarnat for NICUs in Israel, USA, Mexico, Columbia, Brasil, and Argentina .

Physician/Faculty Listing • 3 IMG CCAP physicians, 4 IMG Ward physicians, and 1 Canadian Ward physicians. • 16.7 Neonatologists, 3 Paediatricians, 2 locums Dr. Jill Boulton – Section Chief/Quality Assurance Lead Dr. Alixe Howlett– NPM Program Director and ACH Site Leader Dr. Albert Akierman – PLC Site Leader/ Interim Section Chief Dr. Deborah Clark – RGH Site Leader Dr. Anne Tierney – FMC Site Leader/Interim Deputy Chief Dr. Essa Al Awad - Under-Grad. Education/ Interim PLC Site Leader Dr. Harish Amin - Director Research/SHC Site Leader Dr. Carlos Fajardo - Data Coordinator Dr. Andrei Harabor - Functional Echo Lead Dr. Shabih Hasan Dr. Majeeda Kamaluddeen – NPM Program Director Dr. Abhay Lodha – Chairman, Continuing Medical Education Dr. Jack Rabi – Chair, Finance Committee/ SCM Dr. Reg Sauve - Director of PNFU Dr. Nalini Singhal Dr. Amuchou Soraisham – Coordinator, Post -Graduate Education (Paediatric Residents)

Dr. Wendy Yee – Quality Assurance Coordinator Dr. Kamran Yusuf - Director Research

Clinical Services Provided • 24/7 inpatient neonatal care at the Alberta Children’s Hospital (ACH), Foothills Medical Centre (FMC), Peter Lougheed Centre (PLC), Rockyview General Hospital (RGH), inclusive of 9 clinical services daily, • Responsible for 110 NICU beds and 1460 nights on call with 15.55 FTE Neonatologist. • Emergency resuscitation in the delivery rooms and emergency rooms at perinatal sites. • Emergency clinical care to the Well Newborn Nurseries. • Antenatal-Neonatal consultation at the 3 perinatal sites. • Supervision of neonatal transport for Southern Alberta. • Paediatric consultation at ACH and telephone consultations for paediatricians/family practice/midwives. • Integration of 5 Neonatal Nurse Practitioners, 3.0 FTE Clinical Pharmacists and 2.5 FTE Dieticians at the ACH/FMC/PLC/RGH. • Dr. Amin led the planning for the Paediatric/Neonatal clinical care for South Health Campus (SHC). • Perinatal Follow-up Clinic: 130 clinics, 170 new patients enrolled (criteria: <29 weeks gestation, complex paediatric therapies) and total of 1125 patients seen in the clinic.

Annual Report 2012 | Department of Paediatrics

Section of Nephrology Highlights – Clinical Care, Education, Research and Service to Society Clinical Care: Main organizer of the Transition to Adulthood Symposium in November 2012, Increased support to children/families for procedures (eg urodynamics) from Child Life, Increased Outreach clinics Education Continuing with three fellows in our fellowship program including one, Dr. Anke Banks, a recipient of a Clinical Research Fellowship Award from the Alberta Children’s Hospital Research Institute. Dr. Banks will start her MSc in Medical Education with a research focus in knowledge translation.

patients and parents team completed 100 km in the third Kidney March raising $48,000 for the Kidney Foundation of Canada.

Physician/Faculty Listing Dr. Julian Midgley* - Section Chief, CME director and UME Program Director Dr. Lorraine Hamwika* PGME Program Director Dr. Silviu Grisaru* Dr. Susan Samuel* Dr. James Tee* Dr. Andrew Wade* *Paediatric APPRP Members

Clinical Services Provided • 24/7 Inpatient and Emergency Outpatient Consultation and Admitting Services • Ambulatory Clinics and Services

Research

·· Nephrology Clinic

Research includes examining kidney disease in Aboriginal children and coordination of a national research program to develop national guidelines for treatment of childhood nephrotic syndrome. Silviu Grisaru is conducting a unique community based study to examine blood pressure profiles in children taking stimulant medications such as methylphenidate.

·· Chronic Kidney Disease and Kidney Transplant Clinic

Service to Society

·· Urodynamics Investigation Lab

Andrew Wade is the current President of the Canadian Association of Paediatric Nephrologists. Julian Midgley became the President of the Kidney Foundation of Canada and as a Council Member of the International Paediatric Nephrology Association. These positions that allow work nationally and internationally as an advocate for patients with kidney disease and health professionals caring for them. A larger nephrology clinic staff,

·· Nephrology/Urology Clinic ·· Nephrology/Rheumatology Clinic ·· Meningomyelocoele Clinic ·· Kidney Transplant Transition Clinic ·· Paediatric Haemodialysis Unit ·· Ambulatory Blood Pressure Monitoring • Outreach Clinics ·· Lethbridge 5 times a year ·· Medicine Hat 5 times a year

Department of Paediatrics | Annual Report 2012

Section of Neurology Highlights – Clinical Care, Education, Research and Service to Society The Section of Paediatric Neurology provides neurological care to the children of southern Alberta and neighboring Saskatchewan/British Columbia, and is composed of an extensive team general and subspecialty faculty, trainees and allied health professionals. Excellence in clinical care spans all elements of child neurology. Clinical Care • Continuous urgent care is provided through inpatient on call service and outpatient urgent neurology clinics. Integrated collaborations across complementary specialities provide comprehensive, cross-disciplinary care. ACH Paediatric Neurology cares for >650 inpatient consults annually. Outpatient clinics have increased to >4200 family visits per year including general neurology and subspecialty clinics (see below). Multiple clinical innovation projects and quality improvement/assurance initiatives were executed. Education • Our RCPSC Residency Training Program received full accreditation again in 2011-12. The program has grown to 7 residents (among the largest in Canada), 2 subspecialty fellows, and maintained a 100% success rate on the Royal College exam. All section members are actively engaged in teaching through undergraduate, medical school, residency, graduate student, and post-doctoral fellowship levels. A rich educational environment now includes >10 academic rounds per week.

Annual Report 2012 | Department of Paediatrics

Research • Supported by numerous extramural sponsors, the Alberta Children’s Hospital Research (ACHRI) and the Alberta Children’s Hospital Foundation, our Section experienced rapid academic growth this year. Major operating grants were earned from external agencies included CIHR, AIHS, HSF, NeuroDevNet, CPIRF, and NIH/NINDS. Multiple knowledge translation i nitiatives have directly impacted the clinical care of patients and their families. ·· >$1million in active external funding during this year alone (see below), focused primarily on brain metabolism, neuromuscular, brain injury and paediatric stroke programs)

Clinical Services Provided • Inpatient Consultation and Admitting Services on a 24/7 Basis ·· Inpatient (ward, NICU, PICU) and emergency department ·· Long-term video-EEG monitoring ·· Epilepsy surgery evaluations • Ambulatory Clinics and Services ·· Clinical Neurophysiology Lab (consisting of EEGs, evoked potentials, EMG/NCV studies and intraoperative monitoring) ·· Urgent neurology clinics (weekdays)

·· Epilepsy Clinics (including ketogenic diet and vagus nerve stimulation) ·· Brain Injury Clinics (including Concussion) ·· Stroke Clinics ·· Headache Clinics ·· Neuromuscular Clinic ·· Brain Malformations Clinic ·· Neuromotor Clinics ( multidisciplinary) ·· Neurodevelopmental Clinics (multidisciplinary) ·· Resident Longitudinal Clinics

·· General neurology clinics

·· >40 peer-reviewed original papers and book chapters, and >80 abstracts ·· >30 invited presentations at major national / international meetings ·· >200% growth in research trainees across diverse levels and disciplines

Physician/Faculty Listing Dr. Jong M. Rho* - Section Chief Dr. Karen Barlow* Dr. Luis Bello-Espinosa* Dr. Anita Datta* Dr. Laura Flores-Sarnat Dr. Heather Graham# Dr. Robert Haslam Dr. Alice Ho* Dr. Adam Kirton* Dr. Jean Mah* – PGME Program Director Dr. Aleksandra Mineyko# Dr. Alison Moore# Dr. Harvey Sarnat* Dr. Morris Scantlebury* Dr. Kim Smyth# *Paediatric AARP Members # Part-Time or Associate Sectional Members

Department of Paediatrics | Annual Report 2012

Annual Report 2012 | Department of Paediatrics

Special Feature

ACH Epilepsy Team 2012 was a banner year for the epilepsy group in the Section of Pediatric Neurology. Every year basic and clinical scientists gather at the American Epilepsy Society (AES) meeting that attracts attendees from all over the world. The ACH epilepsy group – including Drs. Buchhalter, Bello, Datta, Rho and Scantlebury presented their research that ranged from basic laboratory science to key clinical studies.

Some of this research done in collaboration with basic scientists as the University of Calgary has demonstrated in pregnant rats that folic acid actually increases susceptibility to seizures in their offspring. This is a very provocative finding as folic acid is considered a paramount intervention to prevent neural tube defects in humans and these results suggest that this supplement may have a deleterious effect if used beyond the time of neural tube closure. The ketogenic diet requires brain cells to metabolize fats instead of glucose and is used in the clinic to effectively treat seizures unresponsive to medications. ACH investigators demonstrated in a simplified model system (brain cells in a dish) that a specific ketone body decreases the ongoing activity of the cells and their ability to be excited. This finding opens up the possibility of finding out exactly how this dietary therapy works and how it can be made more effective. One of the most challenging situations facing clinicians is determining the relationship between seizure number in Childhood Absence Epilepsy and symptoms of Attention Deficit Hyperactivity Disorder, as staring and inattention characterize both conditions. In carefully performed neuropsychological evaluations by Dr. Brian Brooks, it was demonstrated that there is no relationship between the number of absence seizures and the diagnosis of ADHD. Conventional wisdom holds that a child will have either a focal or a generalized epilepsy syndrome and if there is change with time,

the seizures will continue to start from either one place in the brain (focal) or on both sides simultaneously. The ACH epilepsy group reported 3 children in whom this was not true. All initially presented with a generalized epilepsy syndrome (Childhood Absence) but later went on to develop a partial syndrome (Benign Rolandic Epilepsy). These observations indicate that previously held divisions between types of epilepsies may be simplistic and do not reflect the ability of the brain to change how it generates seizures.

The newest member of the ACH Epilepsy team, Dr. Jeff Buchhalter, gave two lectures at the conference. The first described what families want to know about the possibility of Sudden Expected Death in Epilepsy (SUDEP) in their children. The second related to how the various definitions of seizures and epilepsy can be harmonized into one consistent system that can be used in resource poor as well as enriched nations.

Department of Paediatrics | Annual Report 2012

Section of Oncology Highlights – Clinical Care, Education, Research and Service to Society Overall, the section entered the fourth year of the Childhood Cancer Collaborative (CCC), and continued to build research and clinical service in the continuum from the basic science lab to care in the hospital and community. The CCC is a partnership of the faculty research institutes, the University of Calgary, Alberta Health Services and the Alberta Children’s Hospital Foundation. During this year, Drs Lafay-Cousin and Narendran were promoted to Associate Professors of Oncology and Paediatrics. Clinical Care • Acquisition of state-of-the-art apheresis equipment • Recruitment of Dr. Gurpreet Singh as a Clinical Associate • Initiation of the Hospital at Home pilot project Education • Two subspecialty residents (Drs. Alghaithi and Singh) completed their training on June 30, 2012. • Two new subspecialty residents (Drs. Kamra and Shah) began their three years of training on July 1, 2013. • We continued our considerable participation in all levels of education in both the MD and PhD streams. Research • Dr. Lafay-Cousin named Principal Investigator of Children’s Oncology Group study ACNS1221 for young children with desmoplastic medulloblastoma

• Dr. Lewis is the Principal investigator of National Cancer Institute Study IND212 “A pilot study of Imetelstat given intravenously on day 1 and 8 of a 21 day schedule alone and with standard 13-cis-retinoic acid in children with recurrent and/or refractory neuroblastoma. • Dr. Narendran’s laboratory received the designation as the Paediatric Oncology Experimental Therapeutics Investigators Consortium (POETIC) core laboratory for pre-clinical and drug discovery studies. • Kids Cancer Care Foundation of Alberta Chair funds distributed to research grants for the first time. • Annual Paediatric Oncology Research Days were held in November 2011 and November 2012 Service to Society • Drs. Guilcher, Lafay-Cousin, Lewis, Narendran and Strother hold leadership positions within the Children’s Oncology Group, the C17 and the NCIC paediatric oncology clinical trials initiative. • Dr. Strother sits on the Board of Directors of the Kids Cancer Care Foundation of Alberta.

Physician/Faculty Listing Dr. Doug Strother* – Section Chief Dr. Ron Anderson* Dr. Peter Farran Dr. Greg Guilcher * Dr. Lucie Lafay-Cousin* Dr. Victor Lewis* Dr. Aru Narendran* Dr. Kathy Reynolds* Dr. Tony Truong* *Paediatric AARP Members

Annual Report 2012 | Department of Paediatrics

Clinical Services Provided • 24/7 Inpatient and Emergency Outpatient Consultation and Admitting Services • Ambulatory Clinics and Services ·· Oncology ·· Neuro Oncology ·· Blood and Marrow Transplant ·· Long-Term Survivors ·· Paediatric hematopoietic stem cell apheresis ·· Paediatric photopheresis • Outreach

Section of Palliative Medicine Highlights – Clinical Care, Education, Research and Service to Society Clinical • We have had increased numbers of referrals to the Children’s Hospice and Palliative Care Service (CHaPS) and continue to develop innovative processes, pathways and service models to facilitate provision of high quality palliative care to more children and their families. Our model supports continuity of care between home, hospital and hospice and emphasizes collaboration and a blending of care with a child’s community and specialist clinicians. There have been two main areas of expansion of clinical work this year. We are working closely with our colleagues in Oncology to provide services to their population of children with life threatening diagnoses. In

addition we have formed a Perinatal/ Neonatal Palliative Care Working Group with other stakeholders to develop services for this unique population. Education • Section Members continue to provide education in palliative care, ethics and communication to undergraduates and postgraduate students across a number of Faculties using an inter-professional teaching model. Similarly we are involved in provision of a number of workshops for professional development in grief support and palliative care across the city and were instrumental in developing an innovative Advance Care Planning Clinician Training Module used in residency and faculty education. • At a national level members of the Section are playing an important role in education including the application for Royal College Subspecialty status for Palliative Medicine. • Chair, National Postgraduate Education Committee, Canadian Society of Palliative Care Physicians • Coordinator, Paediatric Stream Working Group, Subspecialty Working Group for Palliative Medicine, Canadian Society of Palliative Care Physicians • Members, RCPSC-CFPC Advisory Committee in Palliative Medicine Research, Advocacy and Leadership: • Representation on a number of provincial and national clinical and research networks and committees has provided opportunities to work towards improving access to quality palliative care for all children with life threatening conditions and their families. • Steering Committee and Policy Subcommittee of the Level 1 policy

Department of Paediatrics | Annual Report 2012

development for Advance Care Planning across the province. • Executive of Canadian Network for Palliative Care for Children • Canadian Network of Paediatric Hospices • Canadian Network for Research in Paediatric Palliative Care

Physician/Faculty Listing Section Chief: Dr. Marli Robertson Dr. Mala Arasu* Dr. Leonie Herx* Dr. Kevin Levere* Dr. Corrine Saunders* Dr. Sharron Spicer* *Paediatric AARP Members

Clinical Services Provided • Comprehensive 24/7 consultation service for both inpatient (all Calgary acute care sites) and ambulatory as well as community consultation. • Palliative respite and end of life care at Rotary/Flames House, the only children’s hospice in Alberta. • Ambulatory Clinics and Services • Palliative Care and Grief Support • End of life care in the home supported in collaboration with Home Care Outreach • Telephone and telehealth support for children’s palliative care across Southern Alberta

Annual Report 2012 | Department of Paediatrics

Research Units Behavioural Research Unit Highlights • Dr. Deborah Dewey was awarded the 2012 Department of Paediatrics Academic Leadership Award • Dr. Gerald Giesbrecht, Assistant Professor, Department of Paediatrics, joined the Behavioural Research Unit July 1, 2012. • Dr. Bonnie Kaplan, team lead for APrON (Alberta Pregnancy Outcomes and Nutrition study) and the APrON Team completed its participant recruitment in June 2012, with a sample of >5000 mothers, babies, and fathers.

• Dr. Deborah Dewey and Dr. Lisa Marie Langevin organized a symposium on “Brain, Development and Neurodevelopmental Disorders”; three of the leading researchers in this field in the world, Dr. Marcel Kinsbourne, Dr. Adele Diamond and Dr. Maureen Dennis participated. Undergraduate, Graduate and Postdoctoral Trainees (July 2011 – June 2012) D. Dewey • A Volkovinskaia: BHS, U of C (supervisor) • E Charles: MPH BUCHS, Mwanza, Tanzania (advisor) • H Maulid: MPH CUHAS Mwanza Tanzania (advisor) • K McLeod: MSc Medical Sciences (Neuroimaging), U of C (co-supervisor)

Department of Paediatrics | Annual Report 2012

• H Lee, PhD, Community Health Sciences, U of C (supervisory committee) • F Agajafari, PhD, Community Health Sciences, U of C (supervisory committee) • S Mosca, MSc, Medical Sciences, U of C (Medical Genetics) (supervisory committee) • L Langevin, Postdoctoral Fellow (Supervisor) B. Kaplan • G. Giesbrecht, PhD: Postdoctoral Fellow (supervisor) until July 1, 2012 • B. Leung: PhD, Community Health Sciences, U of C (supervisor) • U. Sayeed: BHS, U of C (supervisor) • L. Benard: MSc Medical Sciences, U of C (supervisory committee) • A. Barnet: BHS, U of C (supervisor) • T. Haig: BHS, U of C (supervisor) • P. Muir: PhD, Dept of Psychology, U of C (external examiner)

Physician/Faculty Listing Dr. Deborah Dewey* - Section Chief Dr. Gerald Giesbrecht Dr. Bonnie Kaplan* * Paediatric AARP Members

Annual Report 2012 | Department of Paediatrics

Services Provided Dr. Deborah Dewey has taken on a number of leadership roles within ACH, the U of C and AHS. She is the Director of the Behavioural Research Unit at Alberta Children’s Hospital. She is also a nonvoting member of the Zone Paediatric Executive Committee. At the University of Calgary she is involved in the following: • Co-theme leader, ACHRI Behaviour and the Developing Brain • Member, ACHRI Strategic Leadership Council • Member, Child and Youth Initiative Committee, University of Calgary • Member, Faculty of Medicine Research Grant Funding Review Committee • Member, CIHR Training Program in Genetics, Child Development and Health Curriculum and Operations Committee, • Member, Steering Committee for the following Chairs ·· Husky Chair in Child Health – Dr. Brent Scott • Cuthbertson and Fischer Chair in Paediatric Mental Health – Dr. Frank MacMaster • Dr. Bonnie Kaplan is a member of the ACHRI Behaviour and the Developing Brain theme.

Research Methods Team Highlights – Education, Research and Service to Society Service – Consultations and Collaborative Research • Continued provision of methodological consultation service supporting high quality research in the Department. • Collaborative research examples: Two members of RMT were Co-investigators in funded University of Calgary new emerging team led by Dr. David Johnson (PI) and also two members of RMT were team members in funded AIHS Collaborative Project grant led by Dr. Adam Kirton (PI). • RMT members are active participants and contributors to ACHRI, including Dr. Hagel serving as co-lead of the Injury Prevention and Optimizing health outcomes theme group.

University of Manitoba. Nicole Romanow MSc (2011) received Canadian Public Health Agency Master’s student award at their annual 2012 conference for a presentation based on her thesis, and now works with our group as a research coordinator. • Two of our current MSc trainees have successfully competed for funding support from Talisman Energy Healthy Living and Injury Prevention Studentship. Research • Drs. Hagel and Nettel-Aguirre, as well as Nicole Romanow, travelled to World Conference on Injury Prevention and Safety Prevention in New Zealand in Fall 2012, and were involved in five oral presentations. • A highlight of our research activity this year was working with and submitting papers for publication with our trainees – both undergraduate and graduate students.

Education • Members of RMT contributed 8 lectures to the Resident Research Course in Fall 2012, with Drs. Hagel and Nettel-Aguirre also leading small group sessions. The RMT also contributed by student (Ken Pfister) and research coordinator (Nicole Romanow) serving as small group leaders. • Members of the RMT teach two graduate courses in the Department of Community Health Sciences. • Dr. Hagel received the Faculty of Medicine Graduate Science Education award for Outstanding Graduate Teaching. • Helen Lee, our second PhD student, completed in 2012. Kelly Russell, our first PhD to complete (in 2011) took up an assistant faculty appointment at the

Department of Paediatrics | Annual Report 2012

• Examples of important clinically and policy relevant publications: ·· Dr. Nettel-Aguirre co-authored a paper with Dr. Samuel (Samuel et al, 2011) on the transition between paediatric and adult care - an important topic that has not received much attention in the literature to date. ·· Drs. Hagel and Nettel-Aguirre both were co-authors on a paper demonstrating the risk of injury associated with bodychecking in minor hockey (Emery et al, 2012) – an important policy issue of relevance to Canadian youth.

Physician/Faculty Listing Section Chief: Dr. Gillian Currie Dr. Brent Hagel Dr. Alberto Nettel-Aguirre

Services Provided The Research Methods Team (RMT) provides methodological support via consultations to child health researchers in the Department of Paediatrics, as well as to members of the Alberta Children’s Hospital Research Institute for Child and Maternal Health (ACHRI). We provide advice on research design and analysis including: design of research studies, data collection, data entry and data management, and statistical analysis of data as well as advice on economic analyses including: conducting costing studies, incorporating economic based outcome measures into research projects, such as quality adjusted life years (QALYs) or other measures of preference for health interventions and how to combine information on costs and outcomes to perform economic evaluation. In addition to providing a consultative service, RMT members are engaged in collaborative research with Department members.

Annual Report 2012 | Department of Paediatrics

Dr. Suzanne Tough Highlights – Education, Research and Service to Society • Principal Investigator of the All Our Babies Study, a multidisciplinary, collaborative longitudinal cohort of 3,300 maternal child pairs investigating the causes and implications of preterm birth and healthy outcomes. • Supervised 5 post-doctoral fellows, 3 PhD students, 1 masters’ student and 10 undergraduate students, as well as mentoring 7 junior investigators, contributing to the training of the next generation of innovative methodological child health researchers. • Continuing as the Scientific Director of the Alberta Centre for Child, Family and Community Research to oversee the development of research and knowledge dissemination activities, ensuring scientific excellence and community relevance, as well as facilitating dialog and partnerships between researchers, policy makers and service providers to promote relevant research and evidenceinformed decision making. • Published the Canadian Clinical Practice Guidelines on Delayed Child-Bearing (Society for Obstetrics and Gynecology of Canada) with Joanne Johnson, resulting in widespread media and policy-maker interest.

Physician/Faculty Listing Dr. Suzanne Tough

Services Provided Dr. Tough has provided service to the University of Calgary, Alberta Health Services, the academic community and the broader

community in several significant ways. She participated in a variety of committees that contribute to the knowledge and operations of the Alberta Children’s Hospital (n=1), the University of Calgary (n=1) and Alberta Health Services (n=4), including the Alberta Health Services’ Women’s Reproductive/ Preconception Health Committee and the Expert Advisory Group for the Provincial Review of Assisted Reproductive Technologies. Further, Suzanne serves on a variety of international, national and local committees, including: PREBIC (World Health Organization), the Institute Advisory Board for the Institute of Aboriginal Peoples' Health (Canadian Institutes of Health Research), Alberta Innovates - Health Solution Platforms Committee, the Canadian Child Health Clinician Scientist Program, the Upstart Council of Champions (United Way of Calgary), andthe Scientific Advisory Panel

for Assisted Human Reproduction Canada Board, for which she was awarded for her exceptional contribution. She participated as a peer reviewer for professional and salary applications, and for both external and internal grant applications. Suzanne also serves the health community through ongoing peer reviews of manuscripts submitted to a variety of journals in relevant areas, including the most recent examples, Social Science& Medicine, Paediatric and Perinatal Epidemiology, and Human Reproduction. Further, Suzanne contributed to the continuing education of investigators, policy makers and the public via invited addresses and workshops (n=12), and participated in media interviews, including TV, radio and newspapers (n=17) to distribute new research findings to the public sphere.

Department of Paediatrics | Annual Report 2012

Section of Respirology Highlights – Clinical Care, Education, Research and Service to Society The Respiratory Section was very proud to add Dr. Glenda Bendiak in Fall of 2012. Dr. Bendiak will aid the Section in all the care pillars and brings special skills in terms of bronchoscopic abilities and knowledge of pre- and post-lung transplant care. The Section has continued to improve access and care delivery. In the footsteps of the ambulatory clinic evolution project for asthma care (ACE), the Pulmonary and Sleep clinics have both undergone significant change. The Sleep Clinic will be utilizing the skills of the Sleep technologists and Specialized nursing in terms of direct patient contact during consultation. This is to address the nation-wide shortage of pediatric trained Sleep physicians. The Pulmonary clinic has consolidated the patient triage process and streamlined followup planning to allow for greater efficiency. Dr. Mark Montgomery received a Queen’s Diamond Jubilee award for his work in the care of children with Cystic Fibrosis in Southern Alberta. Shirley Van der Wetering, the coordinator of the Community Pediatric Asthma Program, received a Medal of Honour from the Alberta Medical Association for her dedication and success in improving the delivery of expert asthma care to the Calgary Zone.

Physician/Faculty Listing Dr. Mark Anselmo* – Section Chief Dr. Marielena DiBartolo* – PGME Program Director Dr. Michelle Bailey (Primary appointment in Hospital Paediatrics) Dr. Candice Bjornson* Dr. Glenda Bendiak* Dr. Valarie Kirk* – Deputy Department Head

Annual Report 2012 | Department of Paediatrics

Dr. Ian Mitchell* Dr. Mary Noseworthy* *Paediatric AARP Members

Clinical Services Provided • 24/7 Inpatient and Emergency Outpatient Consultation and AdmittingServices • Ambulatory Clinics and Services ·· Pulmonary Function Lab ·· Asthma Clinic ·· Respiratory Home Care Clinic ·· Pediatric Sleep Lab ·· Pulmonary Clinic ·· Tracheostomy Clinic with ENT ·· Cystic Fibrosis Clinic ·· Tracheo-esophageal fistula/ Congenital Diaphragmatic Hernia multidisciplinary clinic ·· Community Pediatric Asthma Service ·· Association with Neuromuscular Clinic • Outreach ·· 6 Cystic fibrosis outreach clinics per year. Red Deer, Medicine Hat and Lethbridge, each twice per annum ·· Pulmonary Outreach Medicine Hat, 4 x per year ·· Maintain and co-ordiante Pediatric Asthma Commmunity Program which aids the many Certified Asthma Educators who are embedded in Calgary Pediatric and General Practice clinics. ·· Asthma satellite clinics at the South Calgary Health Center, planning to shift toward the South Health Campus in 2013

Section of Rheumatology Highlights – Clinical Care, Education, Research and Service to Society The Section of Rheumatology provides comprehensive care for children with rheumatic diseases. The ambulatory clinics serve approximately 800 individual patients. We receive over 500 referrals per year. Many children have benefited from treatments in the medical day unit, where children received therapeutic infusions that would normally require inpatient admissions. Research foci include pharmacogenetics in rheumatic diseases, autoinflammatory syndromes (periodic fever syndromes, macrophage activation syndromes, chronic recurrent multifocal osteomyelitis),avascular necrosis and novel autoantibody test development in vasculitidies. Participation in collaborative national and international projects

in childhood rheumatic diseases and in clinical trials in novel biologic agents. Dr. Heinrike Schmeling received the renewal of her CIHR Genetic Clinical Investigator Award. Training is provided to medical students, Paediatrics residents and Adult Rheumatology and Dermatology subspecialty residents. Education includes also three research students. The first Calgary Vasculitis Symposium took place in May 2012 as a result of the Dawson Jarock Endowment Fund.

Physician/Faculty Listing Dr. Nicole Johnson* - Acting Section Chief Dr. Heinrike Schmeling* - Acting Section Chief Dr. Tania Cellucci Dr. Tommy Gerschman Dr. Nadia Luca Dr. Paivi Miettunen* *Paediatric AARP Members

Clinical Services Provided • 24/7 Inpatient and Emergency Outpatient Consultation and Admitting Services • Ambulatory Clinics and Services ·· General Rheumatology Clinic ·· Subspecialty Rheumatology clinics çç Juvenile Dermatomyositis Clinic çç Bone health with focus on avascular necrosis ·· Combined Rheumatology/Nephrology Clinic ·· Transition – Young Adult Rheumatology Clinic (YARD) ·· Paediatric Rheumatology Fetal Maternal Clinic- Neonatal lupus consultation-ad hoc • Outreach- Telehealth consultation ad hoc

Department of Paediatrics | Annual Report 2012

Annual Report 2012 | Department of Paediatrics

Clinical Care The majority of paediatric care is provided in ambulatory and emergency settings, including hospitals, clinics and private offices throughout Calgary. Outreach ambulatory care is provided to numerous locations, including First Nations Health Centres (Eden Valley, Siksika, Stoney and Tsuu Tina), Red Deer, Medicine Hat and Lethbridge. In total, there are 149 paediatric and PICU beds, 113 NICU beds and 7 palliative/hospice beds serving Calgary: • Alberta Children’s Hospital ·· 1 25 Paediatric beds ·· 12 PICU beds ·· 8 Level 3 NICU beds • Peter Lougheed Centre ·· 12 Paediatric beds ·· 33 Level 2 NICU beds • Foothills Medical Centre ·· 39 Level 2/3 NICU beds • Rockyview General Hospital ·· 33 Level 2 NICU beds. • Rotary/Flames House ·· 7 palliative/hospice beds

GLOSSARY OF TERMS

Intracity Transfers

Most Responsible Diagnosis (MRDx)

Child Health

Number of inpatients transferred to another acute care facility, as an inpatient, within Calgary.

The one diagnosis which describes the most significant condition of the patient which causes his stay in hospital. In a case where multiple diagnoses may be classified as most responsible, it should be the diagnosis responsible for the longest length of stay.

Includes all inpatient activity at Alberta Children's Hospital (ACH) as well as activity in dedicated pediatric beds, Unit 31 (and 34 temporarily), at Peter Lougheed Centre (PLC), excluding newborns and patients >= 18 years of age. Discharges Number of inpatients who are discharged from the hospital. Includes deaths and transfers to another institution. Excludes stillbirths. ACH Unique Patients Number of patients treated in ACH. A unique patient is identified based on Unique Lifetime Identifier (uli). Treatment may have occurred as an inpatient or outpatient (in ED, Day Surgery or other). Total Days Stay (LOS)

Total number of accumulated inpatient days (LOS) for patients discharged (including deaths). The day of admission is counted but not the day of discharge. Patients admitted and discharged on the same day count as one inpatient day. Average Length of Stay (ALOS) Total Days Stay (LOS) divided by the number of discharges.

Average Case Weight (ARIW) Total number of accumulated typical and atypical RIW's (Relative Intensity Weight) for patients discharged divided by the number of discharges. RIW's are figures which attempt to approximate the relative amount of resources which go into the treatment of a case and are based on CMG+ grouped and costed Canadian data. A higher RIW usually indicates higher acuity, longer length of stay and increased costs and resources than a lower case weight, with the average being a value of 1. Beds Staffed umber of beds staffed and in operation at the N beginning of the fiscal year. NICU Cases All patients with a portion of stay spent in the following units: FMC 50 & 55, PLC 35B, RGH 63. Discharges include babies transferred to another facility. Unique (NICU) Patients Number of babies transferred in or admitted to a Calgary NICU. A unique patient is identified based on Unique Lifetime Identifier (uli). Average Neonatal Length of Stay per Patient Total number of accumulated inpatient days (LOS) in a Calgary NICU, divided by the number of unique (NICU) patients.

Principal Procedure The procedure considered to be the most significant during the patient's hospital stay. This may be a surgical procedure or, if one was not performed, a non-surgical procedure. Surgical procedures for Child Health are those performed in a main operating room. Day Surgery

Day Surgery activity includes patients registered to Day Surgery who had procedures performed in a main operating room. Patients of all ages are included for Alberta Children's Hospital. Peter Lougheed Centre cases are limited to those less than 18 years of age. Emergency Department (ED) Visit

Includes all patients registered in the Emergency Department, whether seen by a physician or not. Total ACH visits include patients >= 18 years old. Other sites are limited to patients < 18 years of age. Average Length of Stay in Emergency Department - ALOS (Hrs) Average length of time from triage to when the patient left ED for all Emergency Department visits. Time is measured in hours.

Department of Paediatrics | Annual Report 2012

Annual Report 2012 | Department of Paediatrics

Left Without Being Seen (LWBS)

Bronchiolitis Visits & Returns

Number of registered Emergency Department visits where patients left prior to seeing a physician, for any reason.

Patients < 4 years with a MRDx or main diagnosis of bronchiolitis seen at any Calgary hospital as an inpatient or in ED. Bronchiolitis returns are within 72 hours of ED or inpatient discharge for a bronchiolitis-related condition (bronchiolitis, URTI, asthma, croup, respiratory distress, pneumonia).

Emergency Department Admits Number of Emergency Department visits that resulted in patients being admitted to an inpatient unit at the same facility. Emergency Department Transfers Number of Emergency Department visits where patients were transferred to another acute care facility, or to another ED, day surgery or clinic. ACH numbers do not include transfers of adult patients (those 18 years old and over) to other facilities. Ambulatory Visits A visit is defined as an attendance at an ambulatory care service area during which service activities are provided to the service recipient and/or significant other. ProgramSupported is based on MIS Primary Chart of Account for the location patient presented to. Telephone visits are considered an ambulatory visit when they replace a face-to-face visit and are worthy of clinical documentation. They are excluded in face-to-face visit counts. Outcome Indicators Asthma Visits & Returns atients < 18 years with MRDx or main P diagnosis of asthma seen at any Calgary hospital as an inpatient or in ED. Asthma returns are for an asthma-related condition within 72 hours of ED visit. Asthma readmissions are for an asthma-related condition within 7 days of inpatient discharge.

RSV Visits Inpatients < 5 years of age with any diagnosis of bronchiolitis or respiratory syncytial virus (RSV) seen at any Calgary hospital. Forearm Fracture Reduction in ACH ED - % Requiring Subsequent Reduction ACH patients who had a forearm fracture reduction performed in ED and subsequent reduction as an inpatient within 30 days, as a percentage of total ED forearm fracture reductions. Post Tonsillectomy Returns to Hospital Calgary pediatric (age < 18) in-hospital tonsillectomies - performed as an inpatient or in day surgery - who returned within 14 days to inpatient or ED related to the tonsillectomy. Related diagnoses include such things as hemorrhage, sore throat, dehydration, viral infection, gastroenteritis, otitis media, fever, URTI, etc. Direct admits from day surgery are not counted as readmissions.

Department of Paediatrics | Annual Report 2012

Annual Report 2012 | Department of Paediatrics

Special Feature

STEP Team

some complex patients and an understanding of current clinical status and issues. Finally, STEP is involved in educational initiatives, either as they arise from calls or as a result of institutional initiatives to improve patient care.

What is the STEP Team?

STEP Team Implementation

STEP (S-Specialized, T-Transitional, E-Educational, P-Personnel) is the critical care outreach team at ACH. Before team roles and function were detailed, we invited physicians, nurses, and allied health members to participate in a needs assessment to determine the best configuration. While most sites have a physician led team, we determined that the needs at our site were different, partially because we have 24/7 in house paediatricians, which is currently not standard in other paediatric centers and of ward staff concerns about increased acuity and their need for extra support clinically and educationally. We adopted a “ramp up” model, which means that a PICU trained RN and RT attend STEP calls, assess the patient and make a decision as to each patient’s status:

All STEP members are selected for their clinical skills in assessment and strong communication and collaboration skills and complete a course in advance assessment skills supported by the RCPSC. July 4, 2011 STEP had the financial support to go live 8 hours a day. This allowed team members to gain confidence in their new roles, provide education about STEP services to inpatient and clinic areas, and to engage in some education events on the ward. In February 2012 the STEP Team went live 24/7.

STEP Calls Vs. Patient Days 2012

“A” – they need urgent PICU admission “B” – they are borderline and may need PICU admission but may not depending on the success of interventions employed

Our goal is for STEP to respond to pages within 5 minutes and be at the bedside in 15. STEP has achieved this goal over 95% of the time. All delays were either because STEP was already on a call or the STEP RN was pulled to care for a PICU patient. The average response time has been 7.6 minutes. In 2012, there is close to a 50:50 split in day:night calls.43% of the calls were initiated by Nurses, 52% by Physicians and 5% by Allied Health. Call numbers only reflect a portion of work by STEP, as they do not include follow-ups, which can be 5 a day, nor call duration, which in many cases can last for hours. What is interesting to note, however, is the increasing number of calls over time, especially when compared to patient days. We are nearing the end of our first year with full time STEP at ACH and the feedback on individual calls has been outstanding. While we hope that increasing calls and the high satisfaction rating for calls reflect improvements in patient care, this is hard to say, as the variables are many and complex. What we do know is that the role of the team in clinical education and care is valued by front line staff and when patients do transition to PICU (26% of the calls in 2012) that process is more streamlined.

Future Initiatives

“C” – this is a STEP consult only and transfer to PICU is not needed but some support is provided Once this assessment is made, a PICU physician or a NP is called. If designated A or B, the patient is reviewed and a plan is made. A critical aspect of the call is that the most responsible physician is called when the STEP call is made or at least when STEP arrives to the bedside. STEP makes recommendations and helps carry those recommendations out, if accepted, but the most responsible physician maintains responsibility for patient care.

STEP Team Performance

Clinically, we have been asked to increase STEP coverage to the PACU and plans to role out education in terms of calling criteria, etc are underway. We are working with subspecialists to develop education modules for STEP to be involved in specific high needs patients whenever they are admitted which we are excited about. Besides STEP consults, STEP provides a Follow-up Service. Patients leaving the PICU who meet clinical criteria are followed by STEP automatically for 24 hours and longer if the most responsible physician requests it. This is to facilitate smooth transfer of information for

Thanks so much to all STEP team members for their hard work and dedication that has made the team such a success!

DEPARTMENT OF PAEDIATRICS | AnnUAl RePoRt 2012

AnnUAl RePoRt 2012 | DEPARTMENT OF PAEDIATRICS

ACH Activity - 5 Year Trends

ED Visits

Discharges 7,400 7,300 7,200 7,100 7,000 6,900 6,800 6,700 6,600 6,500 6,400

70,000 60,000 50,000 40,000

Discharges

20,000 10,000 -‐

07/08

08/09

09/10

10/11

11/12

42,000 41,000 40,000 39,000 38,000 LOS

37,000 36,000 35,000 34,000 07/08

08/09

09/10

10/11

84,000 82,000 80,000 78,000 76,000 74,000 72,000 70,000 68,000 66,000 64,000

11/12

08/09

09/10

10/11

11/12

Unique Pa4ents (Inpt & Outpt)

07/08 08/09 09/10 10/11 11/12

Ambulatory face to face*

PICU Cases 800 790 780 770 760 750 740 730 720 710 700 690

07/08

Unique Pa*ents (Inpt & Outpt)

LOS

33,000

ED Visits

30,000

240,000 235,000 230,000 225,000 PICU Cases

Ambulatory face to face*

220,000 215,000 210,000

07/08

08/09

09/10

10/11

11/12

205,000

07/08 08/09 09/10 10/11 11/12

DEPARTMENT OF PAEDIATRICS | AnnUAl RePoRt 2012

AnnUAl RePoRt 2012 | DEPARTMENT OF PAEDIATRICS

ACH Inpatient Activity by Most Responsible Physician Division

Medical Divisions

07/08

08/09

09/10

10/11

11/12

Discharges

Total Days

ALOS

Discharges

Total Days

ALOS

Discharges

Total Days

ALOS

Discharges

Total Days

ALOS

Discharges

Total Days

ALOS

Cardiology

602

12.8

663

13.5

310

7.6

345

10.1

306

7.0

Endocrinology

113

2.6

115

2.1

100

2.3

118

2.3

243

2.8

Family Medicine

24.0

133

33.3

2.7

1.3

3.0

Gastroenterology

132

541

4.1

141

845

6.0

136

1014

7.5

145

1010

7.0

155

973

6.3

Hospitalist/Pediatrics

2403

14057

5.8

2305

14237

6.2

2237

14340

6.4

2489

16479

6.6

2353

15221

6.5

5.5

3.5

5.0

6.5

2.8

191

1632

8.5

249

1940

7.8

230

1635

7.1

237

2992

12.6

184

2180

11.8

2.7

4.9

1.0

1.5

1.0

Nephrology

129

509

3.9

119

589

4.9

109

522

4.8

375

4.7

378

5.4

Neurology

279

3.1

291

3.1

122

418

3.4

177

473

2.7

223

665

3.0

Oncology/Hematology

383

4544

11.9

517

4776

9.2

436

4230

9.7

480

4039

8.4

526

4314

8.2

1.0

0.0

108

916

8.5

740

8.1

754

10.2

669

10.5

515

10.7

Rheumatology

5.0

1.8

2.3

0.0

Total - Medical

3,553

23,311

6.6

3,654

24,449

6.7

3,448

23,382

6.8

3,773

26,542

7.0

3,701

24,821

6.7

Infectious Disease Intensivist Medical Genetics

Community Pediatrician Respirology

14,000 12,000

ACH Total (Pediatrics, Surgery, Anesthesia, Mental Health)

10,000

PLC Pediatric Discharges

8,000

NICU Discharges

6,000 Department of Paediatrics

4,000 2,000 -‐

Total Pediatric Admission Calgary

07/08

08/09

09/10

10/11

11/12

90,000 80,000 70,000 60,000

ACH LOS

50,000

PLC LOS

40,000

NICU LOS

30,000

Dept of Pediatrics LOS

20,000

Child Health LOS

10,000 -‐

07/08

08/09

09/10

10/11

11/12

DEPARTMENT OF PAEDIATRICS | AnnUAl RePoRt 2012

AnnUAl RePoRt 2012 | DEPARTMENT OF PAEDIATRICS

ACH Inpatient Length of Stay Trends

Inpatient Age on Admission

Age

ACH Inpatient Length of Stay Trends

2,000

Discharges

1,500

1,000

% Total

PLC

% Total

Total

% Total

0 - 28 Days

430

5.9%

608

50.1%

1038

12.1%

29 Days - 6 Months

719

9.8%

163

13.4%

882

10.3%

7-12 Months

358

4.9%

5.6%

426

5.0%

13 - 23 Months

555

7.6%

7.9%

651

7.6%

2 - 4 Years

1198

16.3%

7.7%

1291

15.1%

5 - 9 Years

1302

17.7%

3.1%

1340

15.7%

10 - 14 Years

1592

21.7%

4.3%

1644

19.2%

15 - 17 Years

1142

15.6%

7.9%

1238

14.5%

0.6%

1214

100.0%

8558

100.0%

18+ Years Total Discharges 500

ACH

0.7%

7344

100.0%

ACH includes all patients. PLC includes patients < 18 years only

0 < 12 Hr

1 Day (12+ Hr)

2 Days

3 Days

4 Days

5 Days

6 Days

7 Days

8 Days

9 Days

10 - 14 Days

15 - 19 Days

20 - 24 Days

25 - 29 Days

30 - 34 Days

35 - 39 Days

40 - 49 Days

50 - 99 Days

100+ Days

07/08

481

1,889

1,186

850

559

400

265

178

133

08/09

477

1,931

1,258

819

651

431

286

190

116

287

128

307

165

09/10

452

1,921

1,200

869

560

362

265

229

152

123

338

134

10/11

477

2,157

1,284

856

577

400

268

212

171

125

351

174

11/12

520

2,110

1,201

857

538

416

287

234

164

109

388

174

103

Length of Stay Days stay is total number of accumulated inpatient days for patients discharged (including deaths) . The day of admission is counted but not the day of discharge. and out the same day or the next calender day.

LOS < 12 hours includes patients in

Department of Paediatrics | Annual Report 2012

Annual Report 2012 | Department of Paediatrics

Major Clinical Classifications of Inpatient Diagnoses

Site

ACH

Major Clinical Classification

06 D&D Digestive System

# PICU Cases

PICU Days

# NICU NICU Cases Days

Code

Most Responsible Diagnosis

Discharges

% Total

Total Days

% Total Days

ALOS

K35

Acute Appendicitis

288

3.9%

813

2.0%

2.8 3.9

14%

4,556

11%

4.5

608

60%

359

Z51

Other Medical Care

257

3.5%

1001

2.5%

19 Trauma Inj Pois & Tox Eff Drug

791

11%

2,633

3.3

525

66%

150

J21

Acute Bronchiolitis

241

3.3%

1094

2.7%

4.5

04 D&D Respiratory System

759

10%

4,179

10%

5.5

104

14%

128

801

J35

Chronic Diseases Of Tonsils And Adenoids

197

2.7%

206

0.5%

1.0

03 D&D Ear, Nose, Mouth & Throat

683

1,761

2.6

513

75%

251

08 D&D MSK Sys & Connect Tissue

587

2,537

4.3

503

86%

104

01 D&D Nervous System

544

3,266

6.0

154

28%

105

327

15 D&D Blood & Lymphatic System

499

3,383

6.8

19%

17 Mental Diseases & Disorders

453

5,108

13%

11.3

14 Nb & Neo w Cond Orig Perin Per

430

5,011

12%

11.7

110

26%

115

509

925

20 Other Reasons for Hosp

344

940

2.7

16%

11 D&D Kid, Urin Tr & M Repr Sys

307

1,240

4.0

175

57%

G40

Epilepsy

195

2.7%

865

2.1%

4.4

Z54

Convalescence

186

2.5%

377

0.9%

2.0

J45

Asthma

169

2.3%

416

1.0%

2.5

F32

Depressive Episode

144

2.0%

1542

3.8%

10.7

R10

Abdominal And Pelvic Pain

131

1.8%

320

0.8%

2.4

S42

Fracture Of Shoulder And Upper Arm

131

1.8%

176

0.4%

1.3

J18

Pneumonia, Organism Unspecified

130

1.8%

542

1.3%

4.2

E10

Type 1 Diabetes Mellitus

100

1.4%

263

0.6%

2.6

10 D&D Endo System, Nutrit & Met

295

2,161

7.3

29%

16 Multisys or Unspec Site Infect

179

992

5.5

12%

S82

Fracture Of Lower Leg, Including Ankle

1.2%

190

0.5%

2.2

Complications Of Procedures, Not Elsewhere Classified

1.1%

652

1.6%

8.0

09 D&D Skin, Subcu Tiss & Breast

155

685

4.4

59%

T81

05 D&D Circulatory System

115

1,041

9.1

42%

213

F90

Hyperkinetic Disorders

1.0%

937

2.3%

12.3

07 D&D Hepatobil Sys & Pancreas

472

5.9

70%

S72

Fracture Of Femur

1.0%

191

0.5%

2.7

02 D&D Eye

176

3.5

61%

S52

Fracture Of Forearm

0.9%

0.2%

1.4

12 D&D Female Reproductive System

121

4.2

45%

G47

Other Sleep Disorders

0.9%

108

0.3%

1.7

18 Burns

411

14.7

64%

D70

Agranulocytosis

0.9%

266

0.7%

4.2

99 Misc CMG & Ungroupable Data

1.8

50%

S06

Intracranial Injury

0.8%

394

1.0%

6.4

7,344

100%

40,680

100%

5.5

3,209

44%

752

2,831

1,442

F43

Reaction To Severe Stress, And Adjustment Disorders

0.8%

513

1.3%

8.6

Z53

Persons Encountering Health Services For Specific Procedures, Not Carried Out

0.8%

0.2%

1.0

R56

Convulsions, Not Elsewhere Classified

0.8%

142

0.3%

2.5

14 Nb & Neo w Cond Orig Perin Per

608

50%

2,458

55%

4.0

1,411

04 D&D Respiratory System

259

21%

684

15%

2.6

06 D&D Digestive System

177

2.4

36%

M21

Other Acquired Deformities Of Limbs

0.7%

104

0.3%

1.9

03 D&D Ear, Nose, Mouth & Throat

134

1.9

33%

A08

Viral And Other Specified Intestinal Infections

0.7%

195

0.5%

3.7

A09

Other Gastroenteritis And Colitis Of Infectious And Unspecified Origin

0.7%

176

0.4%

3.4

K56

Paralytic Ileus And Intestinal Obstruction Without Hernia

0.7%

525

1.3%

10.1

R06

Abnormalities Of Breathing

0.7%

138

0.3%

2.7

11 D&D Kid, Urin Tr & M Repr Sys

132

3.2

19 Trauma Inj Pois & Tox Eff Drug

1.8

66%

01 D&D Nervous System

147

7.0

16 Multisys or Unspec Site Infect

3.3

09 D&D Skin, Subcu Tiss & Breast

4.0

R50

Fever Of Other And Unknown Origin

0.7%

166

0.4%

3.3

10 D&D Endo System, Nutrit & Met

2.3

R62

Lack Of Expected Normal Physiological Development

0.7%

479

1.2%

9.8

20 Other Reasons for Hosp

385

25.7

309

J05

Acute Obstructive Laryngitis [Croup] And Epiglottitis

0.7%

0.2%

1.9

08 D&D MSK Sys & Connect Tissue

3.2

69%

N39

Other Disorders Of Urinary System

0.7%

212

0.5%

4.4

07 D&D Hepatobil Sys & Pancreas

3.1

57%

J06

0.6%

139

0.3%

3.0

12 D&D Female Reproductive System

1.8

33%

Acute Upper Respiratory Infections Of Multiple And Unspecified Sites

15 D&D Blood & Lymphatic System

1.7

Q66

Congenital Deformities Of Feet

0.6%

0.2%

1.7

M41

Scoliosis

0.6%

264

0.6%

6.3

Fracture Of Skull And Facial Bones

0.5%

0.2%

2.0

02 D&D Eye

Total

ALOS # Surgical % Cases Discharges

1,011

Total ACH

PLC

Discharges % Site Total Days % Site Total Stay Total

ACH Inpatient Most Responsible Diagnoses - Top 50%

16.3

99 Misc CMG & Ungroupable Data

2.0

S02

05 D&D Circulatory System

6.5

T18

Foreign Body In Alimentary Tract

0.5%

0.1%

1.3

Unknown

2.0

K59

Other Functional Intestinal Disorders

0.5%

156

0.4%

4.0

Total PLC

1,214

100%

4,508

100%

3.7

115

1,902

G41

Status Epilepticus

0.5%

165

0.4%

4.2

5.3

3,295

39%

200

3,344

B34

Viral Infection Of Unspecified Site

0.5%

0.2%

2.4

8,558

45,188

752

2,831

Notes:

Top 50% Diagnoses

3706

50.5%

14273

35.1%

3.9

Major Clinical Classification is based on Most Responsible Diagnosis and procedures or, in the case of newborns/ neonates, is based on age (< 29 days old) and weight. D&D is Diseases and Disorders.

Total Discharges

7344

100.0%

40680

100.0%

5.5

Surgical cases are those with at least one visit to the Operating Room NICU and PICU days are calculated based on hours spent on these units.

DEPARTMENT OF PAEDIATRICS | AnnUAl RePoRt 2012

AnnUAl RePoRt 2012 | DEPARTMENT OF PAEDIATRICS

PLC Inpatient Most Responsible Diagnoses - Top 10 Diagnoses

Discharges

% Total

Total Days

% Total Days

ALOS

P59

Neonatal Jaundice From Other And Unspecified Causes

344

28.3%

389

8.6%

1.1

J21

Acute Bronchiolitis

124

10.2%

355

7.9%

2.9

P07

Disorders Related To Short Gestation And Low Birth Weight, NEC

8.1%

1951

43.3%

19.9

J18

Pneumonia, Organism Unspecified

5.1%

135

3.0%

2.2

J45

Asthma

3.5%

1.6%

1.7

Z29

Need For Other Prophylactic Measures

2.9%

1.9%

2.4

P55

Haemolytic Disease Of Fetus And Newborn

2.6%

1.0%

1.5

N39

Other Disorders Of Urinary System

1.9%

1.7%

3.3

K35

Acute Appendicitis

1.8%

1.5%

3.0

K07

Dentofacial Anomalies [Including Malocclusion]

1.8%

0.7%

1.5

Top 10 Diagnoses

804

66.2%

3212

71.3%

4.0

Total Discharges

1214

100.0%

4508

100.0%

3.7

TOTAL ACH EMERGENCY VISITS

ACH ED - AVERAGE LENGTH OF STAY (Hours) 3.5

3.6

60,000

3.4

50,000

3.2

40,000 30,000

3.5

70,000

Length of Stay (Hours)

Most Responsible Diagnosis

Total Visits

Code

Calgary Urban Pediatric Emergency Department Activity

59,170

55,954

53,857

59,639

65,016

20,000

3.4

3.2

3.0 2.8 2.6 2.4

10,000

2.2 0 07/08

08/09

09/10

10/11

2.0

11/12

07/08

08/09

09/10

10/11

11/12

ACH Discharges by Region of Residence 2011/12 Discharges

% Total Discharges

Total Days

% Total Days

ALOS

ACH Total

7344

100.0%

40680

100.0%

5.5

Zone 2 - Calgary

6065

82.6%

31897

78.4%

5.3

Zone 1 - South

540

7.4%

3465

8.5%

6.4

Zone 3 - Central

400

5.4%

2666

6.6%

6.7

Zone 4 - Edmonton

0.5%

308

0.8%

8.6

Zone 5 - North

0.3%

220

0.5%

8.8

142

1.9%

1182

2.9%

8.3

Manitoba

0.1%

7.0

Saskatchewan

1.2%

439

1.1%

5.0

Out of Country

0.4%

0.2%

3.8

Other Provinces

0.2%

363

0.9%

22.7

1279

17.4%

8783

21.6%

6.9

Photo courtEsy oF thE ALbErtA chiLdrEn’s hosPitAL FoundAtion

Other Alberta

Other Province/Country British Columbia

Total Non-Zone 2 Zones are as determined by Alberta Health and are based on the postal code of the patient's residence. The report reﬂects the number of patients coming from within the Calgary zone using most recent boundaries and those from other zones, provinces or out of country to receive treatment at ACH.

Department of Paediatrics | Annual Report 2012

Annual Report 2012 | Department of Paediatrics

Community Health Services ACCS Visits Submitted Thru SOS - 2011/12

ACH Ambulatory Care (ACCS) Visits - 2011/12

Program Supported Description

ACCS Visits

Face to Face Visits

Program Supported Description

ACCS Visits

Face to Face Visits

178

Acets Program

884

640

Asthma Clinic

1449

Asthma Clinic

7647

6935

103

Child Abuse Program (Ach)

933

Bereavement And Palliative Care

582

458

Cystic Fibrosis Clinic

126

Brain Injury

1635

1429

Diabetes Clinic (Ach)

Cardiology Clinic

6839

5929

139

Eating Disorders Program

2321

2287

103

Child Abuse Program (Ach)

1755

1426

Endocrinology Clinic

138

Cope Program

216

185

171

Fetal Alcohol Syndrome

Cystic Fibrosis Clinic

3968

2328

Gastroenterology

Diabetes Clinic (Ach)

8524

5609

110

Genetics

139

Eating Disorders Program

32755

32490

117

Hematology Clinic

Endocrinology Clinic

4261

2424

146

Make It Happen

246

171

Fetal Alcohol Syndrome

175

165

190

Metabolic Disease Clinic Ach

Gastroenterology

12522

6747

Nephrology Clinic

110

Genetics

3831

3281

821

Neuro Oncology Clinic

117

Hematology Clinic

1188

1043

Neurology Clinic

Hemophilia Clinic

380

371

Oncology

Infectious Disease Clinic

1354

1351

Pediatric Neuro Developmental Clinic

1045

841

146

Make It Happen

246

Perinatal Clinic

190

Metabolic Disease Clinic Ach

2139

1219

115

Pulmonary Function Lab

Nephrology Clinic

9837

9212

Rheumatology Clinic

821

Neuro Oncology Clinic

797

780

5157

4918

Neurology Clinic

8329

6206

Neuromotor Clinic

5370

4902

Neuromuscular Clinic

1552

1353

111

Neurophysiology Lab

926

122

Neuropsychology Clinic

251

244

Oncology

13067

12263

939

Parenteral Therapy Program

1528

Pediatric Neuro Developmental Clinic

4724

4014

818

Pediatric Sleep Lab

2280

1789

Perinatal Clinic

5199

3836

Pulmonary Clinic

1931

1619

115

Pulmonary Function Lab

562

561

204

Renal Ach Hemodialysis

Respiratory Home Care

4583

3777

Respiratory Services

3792

3791

Rheumatology Clinic

4225

3625

119

Urodynamics Testing

159917

134753

Total

Note: This table includes ACH + Community + Other Centre Pediatrics Clinics

Total

Other Sites' ACCS Visits Submitted Thru SOS - 2011/12 #

Program Supported Description

22 Asthma Clinic

ACCS Visits

Face to Face Visits

933 Bereavement And Palliative Care

126 Brain Injury

139 Eating Disorders Program

5766

5717

58 Infectious Disease Clinic

18 Neurology Clinic

31 Oncology

33 Pulmonary Clinic

115 Pulmonary Function Lab

56 Respiratory Home Care

80 Respiratory Services

5866

5814

34 Cystic Fibrosis Clinic

Total

Department of Paediatrics | Annual Report 2012

Annual Report 2012 | Department of Paediatrics

Pediatric Inpatient Trauma Diagnoses - Age < 18 Yr

Site

External Causes of Injury

Total Inpatient Admissions

ICU Case

LOS

QUARTERLY PERFORMANCE REPORT

NEONATAL INTENSIVE CARE UNIT (NICU) CALGARY ZONE, Alberta Health Services

ALOS

Calendar Year 2012

Emergency Department Visits

Actual Results Performance Measure

Quarter 1

Quarter 2

Quarter 3

Quarter 4

YTD total

Number of Admissions - FMC

296

319

292

303

1210

865

3847

4.4

15796.0

Number of Admissions - RGH

236

247

281

253

1017

1. Transport

146

657

4.5

1109.0

Number of Admissions - PLC

216

206

207

192

821

2. Falls

338

815

2.4

6824.0

Total NICU Admissions all birth weights

748

772

780

748

3048

Includes all 3 sites: FMC, RGH, PLC

3. Drowning/threat to bre

694

20.4

113.0

Includes all 3 sites: FMC, RGH, PLC

4. Exp to smoke/fire/ hot

409

14.6

197.0

5. Assault

275

7.1

194.0

6. Intentional self harm

157

12.1

38.0

7. Other

285

936

3.3

7429.0

ACH

Overall Mortality

8,613

8,082

8,591

8,428

33,714

485

358

475

507

1825

2,256

2,037

2,052

1,873

8,218

Number of Patients with BW <1,000 gms.

103

Number of patients with BW between 1,000 and 1,500 gms.

227

Number of patients with Sepsis dfn: Positive Culture: Blood, CSF, Tracheal)

Bronchopulmonary Dysplasia (BPD as defined by in-house and requires oxygen at 36 weeks)

IVH: Grade III and Grade IV (all Grades)

Retinopathy of Prematurity (ROP) Stages III and IV, (all Stages)

2(22)

4(20)

Total Patient Days - all 3 Units Patient bed availabilty % occupancy Ventilator Days Total Parenteral Nutrition (TPN) Days # Cardiac Patients Transferred for Surgery

Measure of Parent Satisfaction

88.90%

Not Available

Referral Pattern by Birth Hospital

Number of Transports

Comments

Not Available A list of the Hospitals and the # of births at each which were transferred to a Calgary NICU is below

Not Available

Clarification of the dfn of "Transports" is pending. The numbers will be added once a definition is confirmed.

Department of Paediatrics | Annual Report 2012

Annual Report 2012 | Department of Paediatrics

TRANSPORTS: From Birth Hospital to NICU

Transports: From Birth Hospital to NICU

Quarter 1

Quarter 2

Quarter 3

Banff/Canmore

Blairmore

Brooks

Drumheller

FMC has the second highest number of admissions among NICUs in the Canadian Neonatal Network (CNN) Quarter 4

YTD total

Comments 7 1 1

Grande Prairie

High River

Home

Lethbridge

22 2

Medicine Hat

Other

2 0

Stollery/RHA Edmonton

Strathmore

Taber

Total:

192

Out of Province PLC Red Deer/Olds RGH

3 1

Fernie in Q2

Composition of infants admitted to Calgary Zone Level III NICU 2012 Composition of infants admitted to Calgary Zone Level III NICU 2012 ≤ 32 weeks

33-36 weeks

≥ 37 weeks

FMC

26.1%

35.4%

38.4%

1210

ACH

41.0%

21.7%

37.3%

129

Total NICU

27.6%

34.1%

38.3%

1339

Department of Paediatrics | Annual Report 2012

Annual Report 2012 | Department of Paediatrics

Infants < 1250 grams – targeted early colostrum

Year

Number infants < 1250 g

NEC (%)

2009

118

13.6

2010

152

4.4

2011

126

4.8

Number of infants discharged home on oxygen

Incidence of bronchopulmonary dysplasia in two baseline years and four quarters after implementation of open lung strategy

PCVC Off Site Insertion and PCVC management by High Risk Neonatal Transport Nurse – FMC Year January 2012 – December 2012

Year 2012

R VG

PLC

NICUACH

PICU

ACH

Unit 2

Unit 3

Unit 4

Central line: Dressing

High Risk TRN FMC

PCVC insert

Changes

Jan – Dec

Central Line Adjustment

Department of Paediatrics | Annual Report 2012

Annual Report 2012 | Department of Paediatrics

BMT Clinic Children undergoing Blood or Marrow-related stem cell Transplantation (BMT) at the Alberta Children’s Hospital are cared for in the in-patient facility or in the Trican Hematology, Oncology and Transplant Clinic. The referral base includes children from Alberta, Eastern British Columbia and Western Saskatchewan. The transplant program currently cares for children with malignant and non-malignant blood disorders, severe immunodeficiencies and rare genetic disorders. Patients, like Jenna , receive ongoing treatments at the Trican Heamatology, Oncology and Transplant outpatient clinic are transferred back to their referring institutions at completion of treatment or are followed within our Long Term Survivors Clinic co-located within the Trican outpatient facility. Alberta Children’s Hospital was the first pediatric BMT program in Canada to be accredited by the Foundation of Accreditation for Cellular Therapy (FACT) and is extensively involved with local, national and international research initiatives, making it a very progressive transplant center in Canada.

Department of Paediatrics | Annual Report 2012

Education and Training Programs Overview Education at all levels is a fundamental priority for the Department of Paediatrics and all members are expected to participate in direct teaching and/or education leadership throughout the Department, within the Faculty of Medicine, AHS and in the broader community. The Department of Paediatrics is very proud of the accomplishments of its members in paediatric education. Many educational innovations are occurring and being recognized locally as well as nationally and internationally. Paediatric undergraduate medical education is woven throughout the three years of the University of Calgary medical school curriculum, with a combination of didactic and clinical teaching. Post Graduate Medical Education is delivered primarily through the General Paediatrics Residency Training Program, as well as through eleven other Royal College affiliated Residency Training Programs. All programs received full Royal College accreditation at the last RCPSC external review in 2009. Continuing Medical Education is a vital part of paediatric education and contributes to paediatric learning not only within Calgary, but also to physicians via telehealth throughout southern Alberta and southeastern British Columbia. Many faculty members participate in undergraduate education though the O’Brien Bachedor of Health Science program at the University of Calgary. In recent years, Paediatric Simulation education has been especially important in providing hands-on learning to all levels of learners as

well as practicing health care professionals. A new simulation centre is planned to open at ACH in 2013, further assisting in this area of paediatric education.

Annual Report 2012 | Department of Paediatrics

one of the three locations: • Outreach site of Lethbridge, Medicine Hat, or Red Deer (inpatients, outpatients, emergency department, neonatology)

çç Cardiology

• Peter Lougheed Hospital (inpatients, outpatients, emergency department, neonatology)

çç Endocrinology

• Alberta Children’s Hospital (inpatients) The other three weeks will be a combination of (usually) two of the following: • Community Paediatrics

Undergraduate Medical Education

·· The ACH subspecialties available are

• ACH Emergency Department • Neonatology

çç Developmental / Adolescent Medicine çç Gastroenterology çç Infectious Disease çç Nephrology çç Neurology çç Oncology çç Respiratory çç Rheumatology

• ACH subspecialties

UME Director and Clerkship Director: Dr. Susan Bannister UME Deputy Director and Clerkship Deputy Director: Dr. Julian Midgley Clerkship Evaluation Coordinator: Dr. Nicole Johnson Paediatrics is taught throughout Years 1 and 2 of the University of Calgary medical school curriculum (which is three years in duration). The largest amount of paediatric teaching occurs in the Women’s and Child Health course. This course, co-chaired by Dr. Marielena Dibartolo, introduced paediatric clinical skill training for all students this year. (For many years, all students have had neonatal clinical skills training but this was the first year that we expanded the spectrum to include all ages.) In year three, the clerkship year, students rotate through different rotations and spend six weeks learning paediatrics. Our curriculum, based on the national undergraduate paediatrics curriculum, is highly regarded by most students. Most students will complete a three-week rotation in general paediatrics in

Department of Paediatrics | Annual Report 2012

Annual Report 2012 | Department of Paediatrics

Special Feature

canuc-paeds: The Canadian Undergraduate Curriculum for Paediatric Medical Education The paediatric undergraduate team (Drs. Susan Bannister, Julian Midgley and Nicole Johnson) have been involved in the development of canuc-paeds – a national curriculum for undergraduate paediatric education. This project – led by Dr. Bannister – began in 2009 when the Paediatric Undergraduate Program Directors of Canada (PUPDOC) envisioned a curriculum that would be a matrix of objectives, educational resources, and assessment tools. They strove to create a curriculum that would be actually be used by both students and teachers.

Members from the 17 Canadian medical schools spent eighteen months finalizing principles that would guide their future work. For instance, they felt it was essential that the curriculum be grounded in the best practices in medical education, shared and free for teachers and students, bilingual, emphasize generalism, have a Canadian context, and cover all of undergraduate paediatric training. One of the key educational strategies has been the articulation of “foundational knowledge” the knowledge (often basic science knowledge) that is required to approach a clinical presentation. For instance, before a clinical clerk can think about the clinical presentation of murmur, he or she needs to describe the anatomy of the cardiovascular system, explain the basic physiology of cardiac function, and be able to relate the anatomy and physiology to the cardiac physical exam finding. At least ten of 17 Canadian medical schools have adopted the curriculum to some extent. Locally, the curriculum is having an impact. Here at the University of Calgary, the clerkship teaching and examinations are aligned both with the UofC curricular objectives and those of canuc-paeds.

Next steps include posting great educational resources, developing virtual patient cases, creating a national examination bank, and developing a system to ensure the curriculum is up to date. canuc-paeds has been a collaborative process between the 17 Canadian medical schools. Please see its website (www.canuc-paeds.ca) for a list of contributors (shown in photo).

Department of Paediatrics | Annual Report 2012

Post Graduate Medical Education PGME Programs and Trainees There are three paediatric-affiliated PGME programs that being in the PGY1 year – General Paediatrics, Paediatric Neurology and Medical Genetics. (Note that Medical Genetics is a Section of the AHS Department of Paediatrics but is a Department in the Faculty of Medicine.) In addition, there are nine subspecialty paediatric programs that start at the PGY4 level or later – Developmental Paediatrics, Emergency Medicine, Endocrinology and Metabolism, Gastroenterology, Hematology/ Oncology, Infectious Diseases, Neonatology/ Perinatology, Nephrology and Respirology. In 2010-11, there were a total of 89 trainees in all 12 programs. In 2011-12, the total number of trainees increased to 93. General Paediatrics (Program Co-Directors Dr. Deborah Fruitman & Dr. Kathy Tobler) Like all paediatric training programs in Canada, ours is of four years duration. The first three years cover core training in general paediatrics. The first year provides a breadth of exposure to general paediatrics. The second year facilitates career options by exposing residents to subspecialties in greater depth. The third year is designed to consolidate the education acquired in core rotations and to provide opportunities for more elective rotations to deepen knowledge and experience in selected areas. The final year is flexible, with residents able to pursue subspecialty training, or spend more time training as a community or hospital based general paediatrician. Trainees: 2011/2012: 43

Medical Genetics (Program Director Dr. Mary Ann Thomas) The first two years of the program involve training in paediatrics, internal medicine, highrisk obstetrics, and crisis counseling, with on-going communication with the Medical Genetics program director. The third year of the program is devoted to clinical metabolic service and laboratory experience with rotations in cytogenetics, molecular genetics and biochemical genetics. It is possible to begin some clinical genetics rotations in the third year and participation in genetics outreach clinics and resident clinic starts in this year. Attendance at clinical genetic reviews and weekly genetics seminars is recommended. A core month of genetics occurs each year for all residents (R1-R5). he clinical component during the 4th and T 5th years of training is based at the Alberta Children's Hospital. There is an active consulting service in clinical genetics for both in-patients and out-patients through the Alberta Children's Hospital. In addition, there is an extensive outreach program with clinics in Lethbridge, Medicine Hat, and Red Deer. Trainees: 2011/2012: 3 Paediatric Neurology (Program Director Dr. Jean Mah) The Paediatric Neurology Program at the University of Calgary is education driven. During the first year of the program, Residents attend the weekly Paediatric Grand Rounds and participate in other General Paediatric teaching rounds and Paediatric academic half day seminars one half day per week. During the first year, the Residents take part in a 4-week Research methods Course, which enables them to prepare a clinical or basic science research project to be completed within the

Annual Report 2012 | Department of Paediatrics

next two to three years of their training. Most of the 5-year Paediatric Neurology Residency Training Program is spent at the Alberta Children's Hospital with the exception of the rotations in Neonatal Intensive Care, which take place at the Foothills Medical Centre, and rotations in Adult Neurology, which occur at the Foothills Medical Centre, the Peter Lougheed Centre and the Rockyview General Hospital in Calgary. Trainees: 2011/2012: 8 Developmental Paediatrics (Program Director Dr. Ben Gibbard) he University of Calgary offers a two-year T training program in Developmental Paediatrics. The program is designed for 1-2 residents per year.The training program's goal is the development of trainees with excellent clinical skills in an atmosphere of academic inquiry. F ormal teaching sessions (4 hours per month) are held specifically for the residents in Developmental Paediatrics. 100% attendance is expected, as the schedule is set to meet resident and faculty availability. Trainees: 2011/2012: 0 Emergency Medicine (Acting Program Director Dr. Graham Thompson) he Paediatric Emergency Medicine Program T is of two years duration. In the first year, there is an emphasis on gaining the crosstraining components of paediatric emergency medicine. The first year of the fellowship will ensure a significant exposure to the paediatric emergency department experience, as well as completing surgical subspecialties or paediatric subspecialties, depending on where the

resident's core training was. There is also an emphasis on the initiation of research and this is carried through in both first and second years with dedicated blocks. I n the junior year of the fellowship, the resident would participate in the Paediatric or Emergency preparation program for the Royal College examination, i.e., OSCE, written examination practice and history and physician examination observation to help ensure successful outcome in the core specialty. Trainees: 2011/2012: 5 Endocrinology and Metabolism (Program Director Dr. Jonathan Dawrant) The Residency Program in Paediatric Endocrinology and Metabolism was established in November 2002. It is a two-year subspecialty post-graduate program located at the Alberta Children’s Hospital and University of Calgary Faculty of Medicine. Residents receive clinical and academic training in the principles of endocrine and metabolic disease as they apply to children and adolescents and acquire the knowledge and skills necessary to fulfill the essential roles and key competencies of an Endocrinologist as defined by the Royal College of Physicians and Surgeons of Canada. Usually only one or two Residents are enrolled in the program per year and accordingly, individualized teaching and training is provided by our faculty. Upon completion of the program, trainees are equipped to function as consultants in Paediatric Endocrinology either in an independent private practice or in an academic teaching or research program within a university setting. Trainees: 2011/2012: 2

Department of Paediatrics | Annual Report 2012

Annual Report 2012 | Department of Paediatrics

Gastroenterology (Program Director Dr. Leanna McKenzie)

a more substantial research project during their second and third year (if applicable).

Infectious Diseases (Program Director Dr. Rupesh Chawla)

Neonatal/Perinatal (Program Director Dr. Majeeda Kamaluddeen)

The Section of Paediatric Gastroenterology and Nutrition offers two types of subspecialty residency training:

The ten faculty members at Alberta Children’s Hospital demonstrate a commitment to education and have a wide variety of clinical and research interests including Mucosal Immunology, Inflammatory Bowel Disease, Celiac disease, Hepatology, Intestinal Failure, Cystic Fibrosis, Medical Education and Motility.

Training incorporates the principle of increasing responsibility. It includes one year of clinical residency in the entire spectrum of acute, chronic and recurrent infectious diseases in hospitalized and ambulatory patients, with opportunities to participate in epidemiologic studies of infections in the hospital and community. Two months of the one-year experience is spent in adult infectious diseases. Trainees will receive six months of full‑time laboratory residency in medical microbiology including virology, bacteriology, mycology and parasitology. At least one of these sixmonths is committed to virology.One month in spent in Infection Prevention and Control.An additional six months of approved residency in infectious diseases or microbiology or in research is offered, relevant to the goals of the trainee, the objectives of infectious diseases, and acceptable to the program director. Elective experiences outside of Calgary are possible. One of these six months will be in Infection Prevention and Control.

Neonatal/Perinatal Medicine residency program is a two-year program with an optional third year for research. The curriculum includes a minimum of 12 months of clinical rotation. Six months of this is at the Level 3 NICU at Foothills Medical Centre, a tertiary care centre with high risk obstetric and perinatology services and, three months is at the Alberta Children’s Hospital NICU which provides care for surgical, cardiac and complex care neonates. Rotations in neonatal transport, Level 2 nursery and paediatric critical care may be counted towards these 12 months. Participation in research is strongly recommended with time and mentorship allocated for research activity. Research pursuits of the mentors encompass clinical, epidemiological and medical education. Other academic activities include rotations in Maternal-Fetal Medicine, Perinatal follow-up clinic and, participation in academic half-day sessions, clinical rounds, grand rounds and journal club etc.

• A two-year fellowship for trainees wishing to develop clinical skills in paediatric clinical • gastroenterology and nutrition; and • A three-year fellowship combined with Master’s degree or research project for those interested • in pursuing a career in academic paediatric gastroenterology and nutrition. The first year of training is primarily clinical, and residents spend approximately half the year on clinical inpatient service performing supervised consultations at the inpatient units and emergency department of Alberta Children’s Hospital. When not performing inpatient service, trainees participate in outpatient clinics, endoscopy, research, electives and education sessions. The second and third years are similar to the first, but with less inpatient service. Clinical electives are encouraged, and residents are encouraged to arrange electives in nutrition, hepatology (within Canada or international), and pathology. Electives in motility, metabolics, radiology, and research may also be arranged. Trainees pursuing an academic career with a three year residency may enter a basic or clinical science research fellowship, or may pursue a Master’s degree in Clinical Epidemiology, Public Health or Medical Education, with a focus on Gastroenterology. Education time is protected, and residents participate and contribute to the weekly paediatric gastroenterology academic half-day as well as other scheduled teaching sessions. Residents are expected to submit a small research project in their first year, and develop

Trainees: 2011/2012: 5 Hematology/Oncology (Program Director Dr. Macgregor Steele) The Paediatric Hematology/Oncology/BMT Residency Program is of three years duration. The first two years are comprised of the core elements of Hematology/Oncology/BMT. Exposure to the broad scope of this field occurs through rotations in the Paediatric Oncology inpatient ward as well as the outpatient clinic at Alberta Children’s Hospital. Outpatient clinic exposure includes acute and long-term follow-up of oncology, neuro-oncology and BMT patients as well as hematology patients (including hemophiliacs and neonates). In the first two years of training, residents also have opportunity to obtain laboratorybased hematology training at the Children’s Hospital and Foothills Medical Centre. Further rotations include paediatric radiotherapy at the Tom Baker Cancer Centre, paediatric hematology consultations, with optional rotations in adult hematology inpatient service at the Foothills Medical Centre and malignant hematology and BMT on the leukemia/ lymphoma/BMT service at the Tom Baker Cancer Centre. The third year is devoted to research, which is to be original, either with a clinical, translational or basic science focus. Trainees: 2011/2012: 4

The Infectious Diseases clinical service at Alberta Children’s Hospital consists of daily ambulatory clinics and inpatient consultations. The program includes academic rounds with the paediatric infectious disease group as well as city-wide combined adult and paediatric infectious diseases. An academic half-day is organized for ID trainees in both the paediatric and adult programs with a two year cycle of seminar topics. Trainees: 2011/2012: 3

Trainees: 2011/2012: 14 Nephrology (Program Director Dr. Lorraine Hamiwka) The University of Calgary offers a two-year training program in Paediatric nephrology approved by the Royal College of Physicians and Surgeons of Canada. The program is designed for 1-2 clinical fellows per year. During the first clinical year, the trainee performs supervised clinical consultations at the Alberta Children's Hospital in-patient, outpatient, and emergency department services. The trainee develops skills in all aspects of care for the paediatric nephrology patient, including performing management of kidney transplant as well as acute and chronic dialysis of patients. Trainees participate in and contribute to the academic half day for nephrology

Department of Paediatrics | Annual Report 2012

fellows, journal reviews, and the nephrology pathophysiology course. Trainees develop a research proposal, the majority of which will be carried out during the second year of training. Three blocks are available for either research or elective time during the first year of training.

During the second and third year of fellowship, trainees continue to attend outpatient nephrology clinics and perform oncall duties. Up to eight months of research or elective rotations are available. Trainees focusing on a clinical paediatric nephrology traineeship will continue their clinical experience as described for the first year, but at a more advanced level. Trainees pursuing an academic career may enter either a basic or clinical science research fellowship or a medical education fellowship, all with an emphasis on paediatric nephrology. Trainees may also enter into an M.Sc. program for one of the above three academic tracks. Basic science research and clinical research are both carried out at ACH. Trainees: 2011/2012: 4

Annual Report 2012 | Department of Paediatrics

Respirology (Program Director Dr. Marilena DiBartolo)

Continuing Education

We have a 2-year clinical fellowship program, which can be extended towards a research career if desired. There is space for 2 fellows per program year. Most of the clinical work is accomplished in the first year, although there is an expectation that the primary research project will be developed and initiated during this time as well. The main focus of the second year of training is completion of the project. There are components of the program that can be tailored to each individual interest.

CME Director: Dr. Julian Midgely

otations are on a 4 weekly basis (13/year). R One month with the adult respirologists and 2 months in the PICU are part of the program. These months will be planned according the objectives of the fellow in conjunction with the respiratory residency training director in collaboration with other associated programs. There is a further month of elective time allowed which may include such areas as infectious disease, gastroenterology, allergy/immunology, and ENT. Most of the remainder of the first year is made up of in-patient and outpatient paediatric respirology. Trainees: 2011/2012: 4

The Department conducts weekly Paediatric Grand Rounds from September to June of each academic year. These rounds are held in the Auditorium at ACH but are also broadcast via telehealth to other hospitals and offices throughout Calgary,Alberta and southeastern British Columbia. The audience comes from all the disciplines involved in the care of children. Throughout the year, several special named rounds are held including the Dr. Donald Clogg Lecture in Paediatric Emergency Medicine and the Dr. Sam Darwish Lecture in Paediatric Neurology. Of the 41 Grand Rounds in 2012 speakers from outside ACH, including Europe, presented on 14 occasions Most sections conduct regular continuing education rounds, often in conjunction with adult specialty colleagues. These include evening rounds organized by Community Paediatricians often with speakers from ACH paediatric subspecialty sections. The Department of Paediatrics contributes to various Faculty of Medicine CME courses including the Practical Pediatrics Course (held in June), the Evening Course Program for family physicians and the Calgary Therapeutics Course. In February 2012, the 21st International Paediatric Infectious Diseases Course was held in Banff. Dr. Taj Jadavji founded and still directs this longstanding and successful course. In March 2012, the first “PEACH” (Pediatrics Emergencies ACH) conference was held at ACH. Dr. Angelo Mikrogianakis is the director of this exciting new course. In May 2013 another new conference “Paediatric Update” will be launched for family physicians, paediatricians and other paediatric health care workers.

Undergraduate and Graduate Health Sciences Education Members of the Department of Paediatrics contribute to the O’Brien Bachelor of Health Sciences program with classroom teaching, as well as research mentorship and summer student supervision. Members also contribute as graduate and post-doctoral supervisors in various programs throughout the Faculty of Medicine. Paediatric Simulation Education (Medical Director: Dr. Vincent Grant) An internationally-recognized simulation-based education program is located at the ACH, with medical leadership through the Department of Paediatrics. The ACH KidSIM™ Program provides hands-on learning in paediatric acute care to undergraduate and postgraduate learners, as well as to practicing healthcare professionals, with a focus on team training and interprofessional education. Novel programs include a Family Centred Care initiative to use simulation to teach families via simulation, a mobile outreach program that provides interprofessional education to the rural and regional centres in Southern Alberta and Southeastern British Columbia, and a Just-intime Education Program aimed at preparing care providers in real time for patients most likely to deteriorate during their care, among many others. The KidSIM™ Program has also developed a reputation for high quality faculty development through its’ leadership of the nationally-recognized WISE (Workshops In Simulation Education) curriculum and invitations to present faculty development workshops at both national and international meetings. The KidSIM™-ASPIRE (Assessing Simulation in Paediatrics: Improving Resuscitation Education) Paediatric Research Program has become an emerging international leader in simulation-based research, with a significant number of competitive grants, publications, and

Department of Paediatrics | Annual Report 2012

abstracts accepted at national and international conferences. KidSIM™ Faculty Members are also in significant leadership roles in the Faculty of Medicine at the University of Calgary, the eSIM Provincial Simulation Program, the Canadian Paediatric Simulation Network, the Canadian Network for Simulation in Healthcare, the Society for Simulation in Healthcare and the International Paediatric Simulation Society.

Annual Report 2012 | Department of Paediatrics

The program, currently in its’ 8th year of existence, held approximately 400 sessions and taught 3,500 learners in 2011/12. A total of 75 educators provide training using simulators from neonatal to adolescent mannequins. A new $2.4 million dollar simulation centre is expected to open at the ACH in 2013.

Translation Symposium

Due to improvements in medical and surgical care provided to children with chronic disease, there are an increasing number of adolescents and young adults with complex medical conditions surviving into adulthood. It is well recognized that the process of transitioning to adult-centered care is challenging for adolescents, young adults and their families. While some patients transition well, too many cope poorly and fail to access quality care - leading to devastating consequences. Recognizing this problem, the Department of Paediatrics and Alberta Health Services hosted a one day symposium addressing policy and practice improvements for transitional care within the Calgary Zone. The symposium was attended by approximately 160 clinicians and administrators from both adult and paediatric clinical programs and services. We are currently summarizing and collating policy recommendations generated from excellent symposium discussions.

Department of Paediatrics | Annual Report 2012

Awards Academic Leadership Award

• Need to maintain an internal standard of excellence • Committed • Flexible and Adaptable

Clinical/Educator Award

Annual Report 2012 | Department of Paediatrics

trainees. Alternatively, this may be related to communication and education of children and their families, other Department of Paediatric faculty members or community-based organizations. In addition: • Demonstration of excellence in the delivery of clinical care to childrenand their families: • Knowledgeable within the scope of clinical specialty area • Thoughtful use of diagnostic testing procedures and treatmentstrategies • Timely attention to inpatient consults • Professionalism in dealing with colleagues, support staff and families • Calm, reassuring manner when dealing with stressful clinical situations • Empathetic • Good listener

Dr. Deborah Dewey Dr. Deb Dewey has been instrumental in supervising medical students, residents and fellows in their research training and also works with many physicians’ on their masters. She continues to collaborate with department members for clinical research that involves neuropsychology and psychology assessments. Finally, she has proven her dedication to the overall success of the Department’s research activities through her involvement in the Child Health Research Office and in ACHRI. Description of Award Exhibits consistent leadership skills such as: • Ability to motivate and engage others • Self-awareness and ability to bolster the abilities of others through feedback and guidance • Competence at promoting cooperation and building teams • Skills at listening and at sending clear, well-tuned messages • Empathetic • Trustworthy

100

Humanitarian Award

students in Port-au-Prince. His group has been successful in completing projects which allowed the faculties of medicine to resume teaching. In addition they have been successful in securing funds for ongoing projects such as establishing visiting preceptors who are “teaching the teachers” to ensure and enhance the quality of teaching being provided to medical students. Description of Award • Any individual who demonstrates devotion to the promotion of human wellbeing by working to improve the lives of others • Generally would personify such qualities as understanding, empathy, compassion, and dedication to others whom others look up to • Dedicated to the wellbeing of individuals (patients, their families or colleagues), populations or communities • May include (but is not limited to) activities such as: ·· Medical practice ·· Advocacy ·· Teaching ·· Creation of novel programs or services

Dr. Susan Bannister Dr. Bannister’s leadership of the paediatric clerkship program in Calgary, which is comprehensive, high quality and well organized, as well as her leadership of the PUPDOC organization in Canada to further a Canadian paediatric curriculum (with influences on the COMSEP organization across the US also) demonstrate outstanding leadership and are a credit to Dr. Bannister, the University of Calgary Medical School and the Department of Paediatrics. Description of Award Demonstration of excellent skills related to the communication of information to others. This may be in the form of formal teaching, such as lectures and bedside teaching to

Dr. Jean-François Lemay Dr. Lemay has had a significant leadership role working with a Canadian coalition, initiated by the Association of Faculties of Medicine of Canada (AFMC), in collaboration with other medical groups, and has also been involved on projects to rebuild medical programs in Haiti (2010-present) since the earthquake in 2010 killed a significant portion of faculty and

·· Contribution to volunteer organizations • Scope of activities may be local, provincial, national, or international • Contributions may be a single significant recognizable achievement, or consistent behavior/activity that makes a difference in the lives of others

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Department of Paediatrics | Annual Report 2012

Community Paediatrician Award

Annual Report 2012 | Department of Paediatrics

Faculty Awards

(July 1, 2011-June 30, 2012) Alton Ochsner Award

(Presented at the American College of Chest Physicians)

Dr. Shabih U. Hasan

Dr. Janice Heard Janice received her degree in Physical Education at Queens University and a degree in Medicine at the University of Calgary. During her residency at ACH she was co-chief resident. She worked in the ACH ED for many years and then started a community practice in the SW. She has diverse interests and a giving spirit. Her various projects include: teaching in Laos every year, working at the CUPS Clinic and COPE. She also works for the Alumni Office at the University of Calgary. Janice has helped in Uganda with Dr. Jenn Brenner and was the backbone of the Child Abuse Clinic for many years as well as having been on the Board of StrathconaTweedsmuir school. Janice is the mother of three successful grown girls, a golfer, an avid traveller, a philanthropist (as is her husband Bruce). She is a great teacher of students here in Calgary, a supportive friend, practical and kind. Description of Award This annual award shows appreciation of a member of the Calgary Section of Community Paediatricians who: I. Has greatly contributed to the Community (of Calgary and surrounding area)... families and patients/children

RCPSC Mentor of the Year Award Dr. Suzette Cooke

Canadian Thoracic Society Vic Chernick Award Dr. Ian Mitchell

Medal for Distinguished Service (AMA) Dr. April Elliott

Top 40 Under 40 Avenue Magazine Dr. Adam Kirton

II. Has contributed to teaching/education of our own DCP members, Residents and Colleagues, Residents and Colleagues III. Has show compassion, tolerance and fostered camaraderie andcommunication.

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Teaching Awards

(July 1, 2011-June 30, 2012) Resident Teaching Award - Hospital Paediatrician Dr. Lisa Lemieux

Clerkship Teaching Award - Faculty Dr. Kyle McKenzie

Resident Teaching Award - Community Paediatrician

Clerkship Teaching Award Resident PGY1

Dr. Gary Chow

Dr. Erin Kwolek

Dr. George Prieur Paediatric Scholarship

Clerkship Teaching Award Resident PGY2

Dr. Aoife Oâ&#x20AC;&#x2122;Carrol

Dr. Martin Gauthier

Resident Teaching Award - Subspecialist (Section of Critical Care)

Clerkship Teaching Award Resident PGY3

Dr. Jaime Blackwood

Dr. Lindsay Stockdale

Resident Teaching Award - Subspecialty Resident

Clerkship Teaching Award Resident PGY4

Dr. Richy Lee

Dr. Billie Parsely

Terry Klassen Young Investigator Award

Clerkship Teaching Award - Faculty

Dr. Antonia Stang

Dr. Hani Hadi 103

Department of Paediatrics | Annual Report 2012

Annual Report 2012 | Department of Paediatrics

New Faculty

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Dr. Glenda Bendiak, Paediatric Respirology, start date November 1, 2012

Dr. Michael Esser, Neurology/Neurotrauma Research - start date September 1, 2012

Dr. Kristen Johnson, Paediatric Emergency Medicine – start date July 1, 2012

Wes Schreiber Manager for the Department of Paediatrics - start date May 7, 2012

Dr. Andrea Boone, Paediatric Emergency Medicine – start date July 1, 2012

Dr. Stephen Freedman, Paediatric Emergency Medicine – start date September 1, 2012

Dr. Lisa Odendal (nee Dyke) - Paediatric Emergency Medicine – start date October 1, 2012

Dr. Jennifer Thull - Freedman, Paediatric Emergency Medicine – start date October 1, 2012

Dr. Jeffrey R. Buchhalter, Paediatric Neurology – start date October 1, 2012

Dr. Gerald (Gerry) Giesbrecht, Paediatric Neurodevelopmental Investigator, Behavioural Research Unit - Start date July 1, 2012

Dr. Morris Scantlebury, Neurology - start date April 1, 2012

Dr. Alfred Yeung – Gastroenterology, start date August 1, 2012

Dr. Anita Datta, Paediatric Neurology – start date January 1, 2012

Dr. Jennifer Graham, Paediatric Emergency Medicine - start date September 1, 2012

Dr. Jennifer (Jenn) D’Mello, Community Paediatrics - Child Development Services/Child Abuse Physician and Paediatric Emergency Medicine Locum physician – start date January 1, 2012

Dr. Steven Greenway, Paediatric Cardiology start date September 1, 2012

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Department of Paediatrics | Annual Report 2012

Alberta Children’s Hospital Tropical Medicine Clinic

Annual Report 2012 | Department of Paediatrics

Research Funding PI – Principal Investigator Co-PI – Co-Principal Investigator Site PI – Site Principal Investigator Co-I – Co-Investigator

Research Grants Peer Review Funding

As Calgary grows in numbers and diversity, so to are the infectious diseases children present with. In response to these changes, a Tropical Medicine Clinic was opened in September of 2011 by Drs Susan Kuhn and Otto Vanderkooi. The clinic sees immigrants as well as expatriate and traveling children who present with diseases that are suspected to have been acquired abroad. From children with fever who have malaria or typhoid, to more unusual presentations such as lymphatic filariasis and schistosomiasis, a wide range of conditions have been encountered in the first year of operation. More recently the clinic has become a member of a worldwide network tracking imported diseases, the GeoSentinel Global Surveillance System.

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1. 2011-13 Impact of simulation-based skill acquisition instruction (SSAI) on competence in performing effective manual mask ventilation (MMV) in a randomized group of Neonatal Resuscitation Program (NRP) providers Harish Amin (PI) Funding (Total): $ 25,000 Sponsor: Neonatal Resuscitation Program, Canadian Paediatric Society 2. 2012-2013 Funding for Brain Oxygenation & Balance in Post-Concussion Syndrome Study K Barlow (PI) Funding: $58,000 Sponsor: Alberta Children’s Hospital Research Institute 3. 2012-2013 Predicting outcome following mTBI using the 4C-Cognitive tool K Barlow (PI) Funding: $48,500 Sponsor: Alberta Children’s Hospital Research Institute

4. 2012-2013 Research in Clinical Neurotrauma K Barlow (PI) Funding: $100,000 Sponsor: Alberta Children’s Hospital Research Institute 5. 2011-2012 Family Centered Care during bedside Rounds: Effect of an Educational Workshop for Multidisciplinary Hospital Pediatric Teams C Barnard (PI), M Bailey (Co-I), J Brenner (Co-I) Funding: $75,000 Sponsor: ARC Family Centered Care Grant – Alberta Children’s Hospital Research Institute 6. 2009-2015 Outcome Trajectories in Children with Epilepsy: What Factors are Important? Bello-Espinosa LE (Site PI), Thornton N (Co-I) Funding: $350,000 Sponsor: Canadian Institutes for Health Research PI: G Ronen, McMaster University 7. 2012-2013 Finding “Omics” biomarkers to improve the neurodevelopmental health and outcomes of newborns F Bernier (Co-PI), D Dewey (Co-I) Funding (Total): $3,000 Sponsor: Genome Alberta PI: C. Field, University of Alberta 8. 2011-2013 FORGE Canada - Finding of Rare Disorder Genes in Canada F Bernier (Co-I)

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Department of Paediatrics | Annual Report 2012

Funding: $3,500,000 Sponsor: Canadian Institute for Health Research and Genome Canada PI: Kym Boycott, University of Ottawa 9. 2012 Prevalence of malnutrition, its management and impact in hospitalized Canadian pediatric patients D Boctor (Site-PI) Funding: $32,500 Sponsor: Canadian Nutrition Society 10. 2009-2012 Healthy Child Uganda: Can village health volunteers trained in integrated community case management of childhood illness improve access to care for Africa’s most vulnerable children? J Brenner (Co-I), A Nettel-Aguirre (Co-I), N Singal (Co-I) $336,200 IDRC Global Health Research Initiative/ Africa Health Systems Initiative (AHSI-RES) PI: S Maling and Barigye, Mbarara University of Science and Technology, Uganda 11. 2011-2014 Healthy Child Uganda – Muskoka: Impact Evaluation on Maternal and Child Health in Bushenyi and Rubirizi Districts, Uganda J Brenner (Canadian Director) Funding: $3,500,000 Sponsor: CIDA 12. 2010-12 Cell Phone Use to Support Community Health Workers and Improve Child health Outcomes in Rural Western Uganda J Brenner (Co-PI) Funding: $150,000 Sponsor: African Health Systems Initiative (AHSI), International Development and Research Council (IDRC) 13. 2010-12 Review of the Literature-Community Health Workers and Community Case

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Management: Global and Ugandan Process J Brenner (PI) Funding: $15,000 Sponsor: African Health Systems Initiative (AHSI), International Development Research Center (IDRC) 14. 2010-11 Strategic Plan Development for an East African Institute of Maternal and Child Health Training and Research J Brenner (PI) Funding: $15,000 Sponsor: R. Samuel McLaughlin Travelling Medical Education Award 15. 2009-12 Healthy Child Uganda: Impact and Reproducibility of a Village Health Volunteer Child Health Program in Southwest Uganda J Brenner (Co-I, Canadian Lead) Funding: $350,000 Sponsor: African Health Systems Initiative (AHSI) International Development and Research Council (IDRC) 16. 2009-12 Healthy Child Uganda-II: Creating a Reproducable, Low-Cost, ‘Model’ Village Health Volunteer Programme to Promote Child Survival in Uganda J Brenner (Canadian Director) Funding: 75,000 pounds Sponsor: Development Partnerships in Higher Education Grant, British Council

Annual Report 2012 | Department of Paediatrics

childhood illness improve access to care for Africa’s most valuable children J Brenner (PI), N Singhal (Co-I) Funding (Total): $350,000 Sponsor: Canadian Institutes of Health Research 19. 2012 - 2014 Healthy Child Uganda (HCU); Scaling up comprehensive MNCH Programming to create a model District in Bushenyi, Uganda J Brenner (PI), N Singhal (Co-I) Funding (Total): $4,666,574 Sponsor: Canadian Institutes of Health Research 20. 2012-2017 The FACTs Project: Fabry disease clinical research and Therapeutic Genetics R Casey (Co-I) A Khan (Co-I) Funding: $500,000 Sponsor: Canadian Institutes of Health Research PI: Jeff Medin, University of Toronto 21. 2006-2012 Canadian Fabry Disease Initiative (CFDI):“Enzyme Replacement Therapy for Fabry Disease: A Model for Integration of Rare Disease Therapeutics into the Canadian Health Care System” R Casey (PI) Funding: $528,631 Sponsor: Provincial Ministries of Health & Manufacturers

17. 2005-2011 Healthy Child Uganda: “Strengthening Child Health in Rural Uganda” J Brenner (Co-director) Funding: $1,000,000 Sponsor: Canadian International Development Agency (CIDA)

22. 2012-2017 Developing Effective Policies for Managing Technologies for Rare Diseases R Casey (Co-I) Funding: $1,450,166 Sponsor: CIHR PI: Menon D, McCabe C, University of Alberta

18. 2010-2013 AHSI Can Village health volunteers trained in integrated case management of

23. 2012 An Evaluation of the Role of Pediatric Transient Elastography in Assessing

Cystic Fibrosis Associated Liver Disease in Children with Cystic Fibrosis J deBruyn (PI) Supervisor for resident research project for Simon Lam Funding: $3,000 Sponsor: Alberta Children’s Hospital Research Institute 24. 2012 In Support of “Serologic Protection to Routine Vaccinations in Children with Inflammatory Bowel Disease” J deBruyn (PI) Funding: $10,000 Sponsor: Alberta Children’s Hospital Department of Pediatrics Emerging Needs Fund 25. 2011-2013 Immunity and History to Routine Childhood Vaccinations in Children with Inflammatory Bowel Disease J DeBruyn (PI), S Kuhn (Co-I) Funding (total) $49,026 Alberta Children’s Hospital Foundation 26. 2008-2013 Developmental coordination disorder: From genes to behaviour D Dewey (PI), F Bernier (Co-I), K Barlow (Co-I) Funding (Total): $1,135,866 Sponsor: CIHR 27. 2010-2016 Efficacy and Safety of Methlyxanthlines in Very Low Birthweight Infants D Dewey (Co-PI), R Sauve (Co-I) Funding (Total): $2,038,135 Sponsor: CIHR PI: Barbara Schmidt, University of Pittsburgh and McMaster University 28. 2011-2012 The psychosocial and cognitive assessment of allogeneic transplant patients, sibling donors and parents as intervention at the Alberta Children’s Hospital, Hematology, Oncology and

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Department of Paediatrics | Annual Report 2012

Transplant Program D Dewey (Co-I), D Strother (Co-I) Funding (Total): $9,954 Sponsor: Alberta Children’s Hospital Foundation PI: F Schulte, Department of Oncology, University of Calgary 29. 2011-2013 Building parenting capacity in families of children with disabilities: Understanding and resourcing fathers of children with ASD D Dewey (Co-I) Funding (Total): $40,000 Sponsor: Alberta Centre for Child, Family and Community Research PI: B Lashewicz, Department of Community Health Sciences, University of Calgary 30. 2012-2013 Behavioural and developmental outcomes in children receiving early exposure to procedural sedation and analgesia in the pediatric emergency department: Planning a longitudinal Canadian cohort study D Dewey (Co-I), D Johnson (Co-I) Funding (Total): $21,260 Sponsor: CIHR PI: M Bhatt, Montreal Children’s Hospital and McGill University Health Centre 31. 2012-2015 Alberta Pregnancy Outcomes and Nutrition (APrON) - Toxicant - diet interactions on neurodevelopment of children D Dewey (Co-I), GF Giesbrecht (Co-I), BJ Kaplan (Co-I), N Letourneau (Co-I) Funding (Total): $323,926 Sponsor: National Institute of Environmental Health Sciences PI: J. Martin, University of Alberta 32. 2010-2012 Is Electrolyte Maintenance Solution Administration Required in Low-Risk Children with Gastroenteritis? Freedman SB (PI), Boutis K (Co-I), Parkin

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P (Co-I), Goia C (Co-I), Atchison D (Co-I), Schuh S (Co-I) Funding (Total): $169,200 Sponsor: Physicians’ Services Incorporated 33. 2010-2012 Isotonic versus hypotonic IV maintenance fluids in children: a randomized controlled trial Freedman SB (Co-I), Beck C (Co-I) Funding (Total): $46,742 Sponsor: Physicians’ Services Incorporated Co-PI: Geary D, Freidman JN, University of Toronto 34. 2011-2013 Inhaled Magnesium in Refractory Pediatric Acute Asthma Freedman SB (Co-I), Ducharme F (Co-I), Black K (Co-I), Johnson D (Co-I), Beer D Co-I), Plint A (Co-I), Zemek R (Co-I), Guimont C (Co-I), Willan A (Co-I), Thompson G (Co-I), Coates A (Co-I) Funding (Total): $500,920 (Local funds: $91,565) Sponsor: Thrasher Research Fund PI: Schuh S, University of Toronto 35. 2011-2013 Population Based Cohort to Determine Effect of ED Pediatric Gastroenteritis Strategies on Admission and Return Visit Rates Freedman SB (Co-I), Guttmann A (CoSRA) Funding (Total): $20,000 Sponsor: Physicians Services Incorporated PI: Bahm A, Hospital for Sick Children 36. 2011-2015 Impact of Emergency Department Probiotic Treatment of Pediatric Gastroenteritis: Randomized Controlled Trial Freedman SB (PI), Schuh S, Farion K, Sherman P, Johnson D (Co-I), Willan A, Goeree R, Gouin S, O’Connell K, Roskind

Annual Report 2012 | Department of Paediatrics

C, Gorelick M Funding (Total): $1,500,000 Sponsor: The Canadian Institute for Health Research (CIHR) 37. 2012-2013 Abdominal X-Ray Use and the Misdiagnosis Rate in Children with Constipation Freedman SB (PI), Thull-Freedman J (Co-I), Manson D, Schuh S, Rumantir M Funding (Total): $7,298 Sponsor: The Hospital for Sick Children 38. 2012-2013 Management of Acute Gastroenteritis: Synthesizing Evidence to Inform North American Practice. Freedman SB (Co-PI), Hartling L (CoPI), Johnson D (Co-I), Gouin S, Black K, Fitzpatrick E, Bialy L, Klassen T, Belanger F, Hilliard B, Jabbour M. Funding (Total): $100,000 Sponsor: The Canadian Institute for Health Research (CIHR) 39. 2012-2013 Prognosticators of persistent concussion symptoms following pediatric minor traumatic head injury Freedman SB (Co-I), Osmond M, Vassilyadi M The Canadian Institute for Health Research (CIHR) Funding (Total): $17,700 Sponsor: The Canadian Institute for Health Research (CIHR) PI: Zemek RL, Children’s Hospital of Eastern Ontario 40. 2012-2013 Ondansetron Use in Children with Dehydration in a Developing Country Freedman SB (PI), Bhutta Z Funding (Total): $100,000 Sponsor: Bill & Melinda Gates Foundation Grand Challenges Explorations Grant

41. 2011-2013 Children with Acute Gastroenteritis: Predictors of increased length of stay in the emergency department Freedman SB (Co-I) Funding (Total): $2,000 Sponsor: IWK Health Centre PI Schindler N, IWK Health Centre 42. 2008-2012 Impact of Emergency Department Probiotic Treatment of Pediatric Gastroenteritis on Daycare Attendance: Randomized Controlled Trial and Economic Analysis Freedman SB (PI), Johnson D (Co-PI) Funding (Total): $46,673 Sponsor: Alberta Children’s Hospital Foundation 43. 2012 Endotracheal tube palpation to assess endotracheal depth in pediatric patients Gamble J (PI) Funding (total): $4,250 Sponsor: Deans Summer Research Project College of Medicine - University of Saskatchewan 44. 2012-2013 Improving Patient Safety During Anesthesia: Inserting the Catheter Directly into the Lumbar Space Gamble J (PI), Ambros B (Co-I) Funding (total) $6,245 Sponsor: WCVM Research Trust Fund (University of Saskatchewan) 45. 2012 Little movements - lots to learn: validation of a parent questionnaire to screen for developmental coordination disorder in preschool children B Gibbard (Co-I) Funding (Total): $49,716 Sponsor: Alberta Children’s Hospital Foundation Co-PI: B. Wilson and D. Creighton, AHS

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46. 2010-2012 Little movements- lots to learn: early identification of developmental coordination disorder with a parent questionnaire for preschool children B Gibbard (Co-I) Funding (Total): $40,000 Sponsor: Alberta Centre for Child, Family & Community Research Co-PI: B. Wilson and D. Creighton, AHS 47. 2012 Early life experience and child development at 8 years B Gibbard (Co-I) Funding (total): $40,000 Spnsor: Calgary Children’s Initiative PI: S. Leew, University of Alberta and AHS 48. 2012 Developmental Screening in Primary Care B Gibbard (Co-PI) Funding (Total): $30,000.00 Sponsor: University of Calgary Department of Family Medicine Academic Alternative Relationship Research Fund Co-PI: R. Thomas, Department of Family Medicine, University of Calgary 49. 2012-2013 Fetal Programming of Infant Stress Reactivity and Atopic Disease GF Giesbrecht (Co-PI), B Kaplan (Co-I) Funding: $50,000 Sponsor: AllerGen Initiative PI: N Letourneau, Faculty of Nursing 50. 2010-2014 Can adherence to PALS guidelines be improved by team training of pediatric resuscitation team members Gilyfole E (PI) Funding (total): $474,038 Sponsor: CIHR and Heart and Stroke Foundation of Canada 51. 2011- ongoing Prevalance of hypertension among children with ADHD

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S Grisaru (PI) Funding(Total): $3,000 Sponsor: ACH Foundation 52. 2009 – ongoing The role of the Gcm1 transcription factor in mammalian kidney development and physiology S Grisaru (PI) Funding(Total): $44,907 Sponsor: ACH Foundation 53. 2011 Effect of a physical exercise program on the immune system recovery and quality of life in pediatric patients undergoing autologous stem cell transplantation Guilcher, G (Co-I) Funding (Total): $62,827 Sponsor: Childhood Cancer Collaborative 54. 2011-2012 Effect of a physical exercise program on the immune system recovery and quality of life in pediatric patients undergoing autologous stem cell transplantation Guilcher, G (Co-I) Funding (Total): $2,996 Sponsor: Alberta Children’s Hospital Research Institute Small Grant 55. 2011-2012 Enhancing family centered care with allogenic transplant patients, siblings and parents in the Alberta Children’s Hospital Hematology, Oncology and Transplant Program: The use of psychosocial assessment as Intervention Guilcher, G (Co-I) Funding (Total): $9,954 Sponsor: Alberta Children’s Hospital Allied Health and Nursing Grant 56. 2011-2012 Children’s Oncology Group NCI-U10CA98543: Clinical Trial Support Guilcher, G (Co-I) Funding (Total): $62,342

Annual Report 2012 | Department of Paediatrics

Sponsor: Children’s Oncology Group Trial Funding for Division, NCI / National Cancer Institute 57. 2009-2013 Sport Injury Prevention Research Centre B Hagel (Co-Applicant) G Currie (Collaborator) A Nettel-Aguirre (Collaborator) $400,000 International Olympic Committee: Research Centres for Prevention of Injury and Protection of Athlete Health PI: W Meeuwisse, Department of Kinesiology, University of Calgary 58. 2010-2011 Environmental determinants of cycling injuries B Hagel (PI), A Nettel-Aguirre (Co-I) $39,994 Alberta Centre for Child, Family and Community Research 59. 2009-2013 Child Pedestrian Injury: Advancing research methods, knowledge of injury etiology, and prevention approaches B Hagel (Co-I) $481,869 Canadian Institutes of Health Research PI: B Morrongiello, University of Guelph 60. 2011-2012 Evidence based education for paediatric injury prevention B Hagel (Co-PI), A Mikrogianakis (Co-I), V Grant (Co-I) $9,999 Alberta Centre for Child, Family and Community Research PI: Dr. Ferri-de-Barros, Department of Surgery, University of Calgary 61. 2009-2014 Child and Youth Injury Prevention B Hagel (Co-Investigator) $2,000,000 Canadian Institutes of Health Research

PI: I Pike, University of British Columbia and Dr. A Macpherson, York University 62. 2007-2013 Podocyturia as an Early Marker of Renal Damage in Adolescent Obesity: A Pilot Study L Hamiwka (PI) Funding(Total): $34,616 Sponsor: ACH Foundation 63. 2010-2013 Infant Car Safety Seats and Cardiorespiratory Events in Preterm Infants SU Hasan (PI) Funding (Total): $30,000 Sponsor: The Lung Association, Alberta and NW Territories 64. 2010-2011 Post Market Drug Safety and Effectiveness of Atypical Antipsychotics in Children with Disruptive Behaviour Disorders, Mood Disorders and Developmental Disorders J Ho (Collaborator) Funding (Total): $66,826 Sponsor: Canadian Institute of Health Research PI: T Pringsheim Department of Clinical Neurosciences, University of Calgary 65. 2009- 2012 Identification of Biomarkers of Diabetic Neuropathy Using Proteomic Analysis in Children With Type 1 Diabetes J Ho (PI), D Pacaud (Co-I) Funding (Total): $2,961 Sponsor: Alberta Children’s Hospital Foundation 66. 2009- ongoing Family Intervention for Obese Children Using Portion Control Strategy (F.O.C.U.S.) for Weight Control- A Randomized Controlled Trial J Ho (PI), C Huang (Co-I) Funding (Total): $49,935 Sponsor: Alberta Children’s Hospital Foundation

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Department of Paediatrics | Annual Report 2012

67. 2007-2011 A Comparison of Insulin Detemir in a BID Insulin Regimen Versus a TID Insulin Regimen in Children with Type 1 Diabetes: A Randomized Controlled Trial J Ho (PI), D Pacaud (Co-I), C Huang (Co-I) Funding (Total): $44,235 Sponsor: Alberta Children’s Hospital Foundation 68. 2012-2015 Placenta hormones as adjunct in treatment of diabetes C Huang (PI) Funding (Total): $271,793 Sponsor: Canadian Diabetes Association 69. 2011-2012 The Efficacy of Prolactin in Enhancing Beta Cell Mass and Function in Type 1 Diabetes C Huang (PI) Funding (Total): $49,816 Sponsor: Alberta Children’s Hospital Foundation 70. 2010-2012 Role of Adiponectin on Beta-Cell Proliferation C Huang (PI) Funding (Total): $49,454 Sponsor: Alberta Children’s Hospital Foundation 71. 2008-2015 Natural History Study of the Development of Type 1 Diabetes; sub-study: Oral insulin for prevention of Diabetes in Relatives at Risk for Type 1 Diabetes Mellitus C Huang (Site-PI), D Pacaud (Co-I), D Stephure (Co-I), J Ho (Co-I) Funding (Total): $15,000.00 per year; $155.00 per patient Sponsor: NIH, NIDDK, NIAID, NICHD, NCRR, JDRF, ADA/University of South Florida PI: D Wherret, University of Toronto

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72. 2011 Use of trio-based whole exome sequencing to identify the causes of sporadic syndromic intellectual disability: a pilot study with implications for the investigation for de novo Paediatric Disease M Innes (PI) Funding: $49,384 73. 2011-2012 Investigation of FBX028, A Candidate Causative Gene for a Chromosome 1q41q42 Microdeletion syndrome Associated with Intellectual Disability and Seizures M Innes (PI) Funding: $2620 Sponsor: Alberta Children’s Hospital Foundation 74. 1991- ongoing Immunization Monitoring Program Active (IMPACT) T Jadavaji, (Site-PI), OG Vanderkooi (Co-I) as part of country wide investigative network Funding (total) 1,200,000 Sponsor: Public Health Agency of Canada & Canadian Pediatric Society PI: JA Bettinger, University of British Columbia 75. 2011-2014 The Implementation and Evaluation of an Alberta Childhood Asthma Clinical Pathway D Johnson (PI), G Currie (Co-I), A Nettel-Aguirre (Co-I), S Spier (Co-I) Funding (Total): $350,000 and $149,980 Sponsors: CIHR Partnerships for Health System Improvement and AIHS 76. 2011-2015 Translating Emergency Knowledge for Kids (TREKK) Johnson D (Co-Director), Currie G (Co-I) Freedman SB (Co-I), Stang A (Co-I) Local funds: $140,000 / $140,000 (ACHRI) Sponsor: Funding: National Centres

Annual Report 2012 | Department of Paediatrics

of Excellence of Canada Knowledge Mobilization Grant and Alberta Children’s Hospital Research Institute PI: Klassen T, University of Manitoba 77. 2011-2014 Combined Glucocorticoid Adrenergic Therapy (CONjuGATE) D Johnson (co-PI), A Stang (co-PI), G Currie (Co-I), A Nettel-Aguirre (Co-I) Funding (Total): $300,000 Sponsor: University of Calgary Emerging Team Grant Competition 78. 2012-2015 Developing an Internet-based program for anxious youth who visit the emergency department for mental health care Johnson D (Co-I) Funding (Total): $412,582 Sponsor: CIHR operating grant PI: Newton AS, University of Alberta 79. 2012-2013 Efficacy of combination therapy with intravenous ketorolac and metoclopramide for pediatric migraine therapy in the ED - a randomized placebo controlled trial Johnson D (Co-I) Funding (Total): $99,961 (Local funds $49,713) Sponsor: CIHR Catalyst Grant: Post Market Drug Safety and Effectiveness PI: Richer L, University of Alberta 80. 2006-2012 CIHR Team in Pediatric Emergency Medicine D Johnson (co-PI), G Currie (Co-investigator) $3,917,164 Canadian Institutes of Health Research PI: T Klassen, University of Manitoba 81. 2012-2015 The LEAP study: Linking Exercise, Activity and Pathophysiology in Juvenile Idiopathic

Arthritis N Johnson (Site PI), P Miettunen (Co-I), H Schmeling (Co-I) Funding (total): $2,220,000 Sponsor: CIHR PI: C Duffy, University of Ottawa 82. 2012-2015 Teens Taking Charge: An Internet-based Self-management Program for Adolescents with Arthritis: A Randomized Controlled Trial N Johnson (Co- I), P Miettunen (Co-I), H Schmeling (Co-I) Funding (total): $440,000 Sponsor: CIHR, Canadian Arthritis Network (CAN), The Arthritis Society (TAS), Canadian Arthritis Patient Alliance (CAPA) PI J Stinson, University of Toronto 83. 2008-2013 The impact of maternal nutrient status during pregnancy on maternal mental health and child development BJ Kaplan (Team Lead), D Dewey (CoTeam Lead), F Bernier (Co-I) Funding (Total): $5,000,000 Sponsor: AIHS 84. 2012-2013 A KT initiative for policymakers on the importance of cohort research B Kaplan (PI), D Dewey (Co-I), C Field, M O’Beirne, D Johnston (Co-I), S Tough (Co-I), P Mandhane, B Leung Funding: $25,000 Sponsor: Alberta Innovates Health Solutions 85. 2010-2015 CIHR Emerging Team Grant: Canadian Microbiome Initiative JD Kellner (Co-I) Funding (total) $2,484,542 ($260,649 in 2010-11) Canadian Institutes of Health Research (CIHR) Sponsor: CIHR Emerging Team Grant PI: DME Bowdish, McMaster University

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Department of Paediatrics | Annual Report 2012

86. 2009-2014 Evaluation of Meningococcal C Conjugate Vaccine Programs in Canadian Children JD Kellner (Site-PI) OG Vanderkooi (Co-I) Funding (total) $699,663 Canadian Institutes of Health Research (CIHR) Sponsor: CIHR Institute of Population and Public Health Operating Grant PI: JA Bettinger, University of British Columbia 87. 2008-2013 AHFMR Interdisciplinary Team Grant in Vaccine Design and Implementation JD Kellner (co-team leader), A Schryvers, L Babiuk; G Currie (collaborator) Funding (total)$5,000,000. Sponsor: Alberta Heritage Foundation for Medical Research Interdisciplinary Team Grant Competition 88. 2009-2012 PCIRN: PHAC/CIHR Influenza Research Network JD Kellner (Co-I) S Kuhn (Co-I), OG Vanderkooi (Co-I) Funding (total) $10,154,575 Sponsor: Canadian Institutes of Health Research (CIHR) and Public Health Agency of Canada PI: SA Halperin, RA Bortolussi, JP Collet, G De Serres, MM Johnson, JC Kwong, SA McNeil, DW Scheifele, BJ Ward 89. 2012-2015 Enhancement of developmental motor plasticity in perinatal stroke with Transcranial Direct Current Stimulation A Kirton (PI), D Dewey (Co-I) Funding total: $270,000 Sponsor: Heart and Stroke Foundation 90. 2011-2014 Pathophysiology of Perinatal Stroke A Kirton (PI), K Yusuf (Co-I) Funding (Total): $150,000

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Sponsor: NeuroDev Net 91. 2011-14 Biological Markers of Perinatal Stroke A Kirton (PI), K Yusuf (Co-I) Funding (Total): $50,000 Sponsor: Alberta Children’s Hospital Foundation, Alberta Children’s Hospital Research Institute 92. 2012-2015 Robotic assessment of proprioceptive dysfunction in children with perinatal stroke A Kirton (PI) Funding: $100,000 Sponsor: Cerebral Palsy International Research Foundation 93. 2012-2013 Biological markers of pediatric cerebrovascular inflammation and stroke A Kirton (PI) Funding: $36,100 Sponsor: Alberta Children’s Hospital Research Institute 94. 2011 Biological markers of perinatal stroke: BioMaPS A Kirton (PI) H Schmeling (Co-I) Funding: $50,000 Sponsor: Alberta Children’s Hospital Research Institute (ACHRI) Research Grant 95. 2012-2015 Spatial cognition and orientation skills in children with perinatal stroke A Kirton (PI) Funding: $225,000 Sponsor: AIHS Clinician Fellowship, Clinician Researcher Training Stream (Dr. Kara Murias) 96. 2012-2014 Understanding the neurophysiology of pediatric migraine with TMS A Kirton (PI) K Barlow (Co-I) Funding: $136,000 Sponsor: CIHR Training Program in

Annual Report 2012 | Department of Paediatrics

Genetics, Child Health, and Development. Clinical Research Fellowship (Dr. Thilinie Rajapakse) 97. 2012 Impact of perinatal stroke on parents and families A Kirton (PI) Funding: $43,000 Sponsor: AIHS/HBI Perinatal Determinants of Brain and Mental Health Graduate Traineeship and AIHS Graduate Studentship (Ms. Taryn Bemister) 98. 2012 Cerebral diaschisis in neonatal arterial ischemic stroke A Kirton (PI) Funding: $7,000 Sponsor: Canadian Stroke Network Summer Studentship Award (Ms. Jamie Roe) 99. 2012 Time course of cerebral diaschisis in childhood arterial ischemic stroke A Kirton (PI) Funding: $5,200 Sponsor: Alberta Innovates, Health Solutions Summer Studentship Award (Ms. Elizabeth Williams) 100. 2012 Quantification of gliosis in perinatal stroke and relationship to outcome A Kirton (PI) Funding: $5,200 Sponsor: Alberta Innovates, Health Solutions Summer Studentship Award (Mr. Siddharth Shinde) 101. 2011-2013 Diffusion tensor imaging of corticospinal tract integrity in perinatal stroke A Kirton (PI) Funding: $40,000 Sponsor: CIHR Training Program in Genetics, Child Health, and Development.

Graduate studentship (Ms. Jacquie Hodge) 102. 2011 Quantifying cortical injury in fetal stroke A Kirton (PI) Funding: $7,000 Sponsor: Canadian Stroke Network Summer Studentship Award (Mr. Damon Li) 103. 2011 Cerebral diaschisis in childhood arterial ischemic stroke: Quantification and evolution A Kirton (PI) Funding: $5,200 Sponsor: Alberta Innovates, Health Solutions Summer Studentship Award (Ms. Jamie Roe) 104. 2012 International Maternal Newborn Stroke Registry A Kirton (Co-I) Funding: $40,000 Sponsor: World Federation of Neurology PI: C. Bushnell, Wake Forest University 105. 2011-2013 Childhood Hemiplegic Cerebral Palsy Integrated Neuroscience Discovery Network “CP-NET” A Kirton (Co-I) Funding: $1,997,000 Sponsor: CP-NET PI: D. Fehlings, Bloorview-MacMillan Rehabilitation Hospital 106. 2011-2013 Transcranial Magnetic Stimulation for Adolescent Depression A Kirton (Co-I) Funding: $240,000 Sponsor: Alberta Children’s Hospital Foundation, CHAS PI: FP MacMaster, Department of Psychiatry, University of Calgary

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107. 2011-2013 Expansion of a Canadian Multi-Regional Population-Based Cerebral Palsy Registry A Kirton (Co-I) Funding: $520,000 Sponsor: Public Health Agency of Canada PI: M Shevell, McGill University 108. 2010-2014 A Canadian Multi-Regional PopulationBased Cerebral Palsy Registry A Kirton (Co-I) Funding: $520,000 Sponsor: NeuroDevNet (National Centers of Excellence) PI: M Shevell, McGill University 109. 2011-2016 Thrombolysis in pediatric stroke (TIPS): A safety study of tPA in acute childhood stroke A Kirton (Co-I) Funding: $1.9 million (USD) Sponsor: National Institutes of Health (NIH) PI: G deVeber, University of Toronto 110. 2009-2012 Diagnosis of axonal degeneration following cerebral hypoxic-ischemic injury in neonates A Kirton (Co-I) Funding: $165,000 Sponsor: Heart and Stroke Foundation of Alberta PI: U Tuor, Department of Pharmacology and Physiology, University of Calgary 111. 2009-2014 Vascular Effects of infection in pediatric stroke (VIPS) A Kirton (Co-I) Funding: $5.8 million (USD) Sponsor: National Institutes of Health (NIH) and Canadian Institutes of Health Research (CIHR) PI: H Fullerton, University of California at San Francisco 112. 2009-2012

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Modulation of brain plasticity after perinatal stroke A Kirton (PI), K Barlow (Co-I), A NettelAguirre (Co-I) Funding: $225,000 Sponsor: Heart & Stroke Foundation of Alberta, NWT&Nunavut 113. 2010-2013 Pathophysiology of perinatal stroke A Kirton (PI), A Nettel-Aguirre (Co-I) Funding: $150,000 Sponsor: NeuroDevNet Opportunities Initiative 114. 2011-2013 Clinical Review and Cost Evaluation of a Pediatric Home Parenteral Therapy Program S Kuhn (PI), OG Vanderkooi (co-PI) Funding (total) $25,000 Sponsor: Department of Paediatrics, University of Calgary 115. 2012 Programme integré de formation neurologique de base pour les étudiants de medicine de la FSSA afin de répondre aux besoins sanitaires haitiens de premiere ligne JF Lemay (PI) Funding: $24,780 Sponsor: Canadian Bureau of International Education Minister of Foreign Affairs and International Trade Government of Canada 116. 2012 Programme integré de formation Clinique Chirurgicale de base aux étudiants de medicine en stage de chirurgie de la FSSA JF Lemay (PI) Funding: $21,450 Sponsor: Canadian Bureau of International Education Minister of Foreign Affairs and International Trade Government of Canada 117. 2010-2013 Fetal Programming of Infant Stress Reactivity

Annual Report 2012 | Department of Paediatrics

N Letourneau (Co-PI), GF Giesbrecht (Co-I), BJ Kaplan, (Co-I) Funding: $411,738 Sponsor: Canadian Institutes of Health Research PI: T Campbell, Department of Psychology, University of Calgary 118. 2011- 2012 CIBMTR database for patients receiving myelotoxic chemotherapy and stem cell transplantation Lewis, V (Site-PI) Funding (Total): US $65,620 Sponsor: Center for International Blood and Marrow Transplantation Research/ National Marrow Donor Program (CIBMTR) 119. 2011-2012 Health related quality of life in survivors of neuroblastoma who have undergone megatherapy and hematopoietic stem cell transplantation: A national perspective 2012-2013 Lewis, V (Co-I) Funding (Total): $26,000 Sponsor: Public Health Agency of Canada PI: Carol Portwine, McMaster University 120. 2011-2012 Non-HLA immunogenetic biomarkers important for pathogenesis and therapy of complications of paediatric hematopoietic cell transplantation (2011-2015) Lewis, V (Co-I) Funding (Total): $250,0000 Sponsor: Alberta Children’s Hospital Foundation - Cancer Care Collaborative PI: Faisal Khan, Departments of Pathology & Laboratory Medicine, University of Calgary 121. 2011-2012 Assessment of t-cell receptor excision circle (TREC) quantity after hematopoietic cell transplantation: a biomarker for immune reconstitution and thymic function Lewis, V (Co-I) Funding (Total): $25,000

Sponsor: Alberta Children’s Hospital Foundation/ KCCF Chair in Pediatric Oncology PI: Faisal Khan, Departments of Pathology & Laboratory Medicine, University of Calgary 122. 2011-2012 Randomized Controlled Trial to Study the Effect of Nasal Continuous Positive Airway Pressure (NCPAP) Cycling on Successful Weaning When Compared with NCPAP in Premature Infants of 25–28 Weeks Gestation A Lodha (PI) H Amin (Co-I) Funding (Total): $ 3,000 Sponsor: Alberta Children’s Hospital Research Institute (ACHRI) 123. 2011-2013 Metformin in women with type 2 diabetes in pregnancy trial A Lodha (Local Co-I), L Donovan (Site PI) Funding (Total): $1,780,000 Sponsor: Canadian Institutes of Health Research (CIHR) PI: DS Feig, University of Toronto 124. 2011-2013 Overcoming surfactant inhabitation in neonates and infants– a clinical prospective cohort study with an animal model correlate A Lodha (PI) Funding (Total): $49,200 Sponsor: Alberta Children’s Hospital Research Institute (ACHRI) 125. 2006-2013 Long-term outcomes of infants with Chronic lung disease A Lodha (PI) R Sauve (Co-I) Funding (Total): $ 20,000 Sponsor: Alberta Children’s Hospital Foundation 126. 2012-2014 Seminal Canadian Recommendations for

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Department of Paediatrics | Annual Report 2012

Evidence–Based Examination of Neonates for Retinopathy of Prematurity (SCREEN– ROP) Study A Lodha (Site PI), A Ells (Site Co-I) Funding (Total): $ 455,000.000 Sponsor: Canadian Institutes of Health Research (CIHR)/McMaster University PI: K Sabri, McMaster University 127. 2012-2013 Caring for late preterm infants: public health nurses’ and Parents’ experiences A Lodha (Co-I) Funding (Total): $ 40,000 Sponsor: Alberta Centre for Child, Family and Community Research PI: S Premji, Faculty of Nursing, University of Calgary 128. 2012-2017 Enhancing Breast Milk Production Domperidone in Mothers of Preterm Neonates (EMPOWER Study) A Lodha (Site PI), J Boulton (Co-I) Funding (Total): $ 999,454 Sponsorship: CIHR PI: E Asztalos, University of Toronto 129. 2011-2012 Long term growth and neurodevelopmental outcomes of newborns with gastroschisis: a cohort study A Lodha (PI) Total (Funding): $ 24,453 Sponsor: Alberta Children’s Hospital Research Institute (ACHRI) 130. 2011-2013 Meta Analysis: Metformin Exposure and Immediate Neonatal Outcomes A Lodha (PI) Funding (Total): $ 3,000 Sponsor: Alberta Children’s Hospital Foundation 131. 2011-2013 A Multicenter Collaborative Study on the Clinical Features, Expression Profiling, and Quality of Life in Pediatric Fascioscapulohumeral Muscular Dystrophy

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JK Mah (PI) Funding: $96,669 Sponsor: US FSH Society and Muscular Dystrophy Canada 132. 2009-2013 Longitudinal Study of the Relationship between Impairment, Activity Limitation, Participation and Quality of Life in Persons with Confirmed Duchenne Muscular Dystrophy JK Mah (Site PI) Funding: $2.3 million Sponsor: US Department of Defense and Cooperative International Neuromuscular Research Group PI: C MacDonald, University of California at Davis 133. 2009-2014 Phase 2 study on the clinical-demographic, epidemiology, pathobiology, neuroimaging features and outcome of acute demyelination in Canadian children JK Mah (Site PI) Funding: $4.6 million Sponsor: Multiple Sclerosis Scientific Research Foundation of Canada PI: B Banwell, Hospital for Sick Children 134. 2011-2016 FOR-DMD: Double-blinded, Randomized Trial to find Optimum Steroid Regimen JK Mah (Site PI) Funding: $3.3 million Sponsor: US National Institute of Health Co-PI: R Griggs, University of Rochester and Kate Bushby, Newcastle upon Tyne 135. 2010-2014 PITT0908: Clinical Trial of Coenzyme Q10 and Lisinopril in Muscular Dystrophies JK Mah (Site PI) Funding: $1.6 million Sponsor: US Department of Defense and Cooperative International Neuromuscular Research Group PI: P Clemens, University of Pittsburgh

Annual Report 2012 | Department of Paediatrics

136. 2010-2012 Determining the relationship between chronic cerebrospinal venous insufficiency and multiple sclerosis Funding: $255,000 JK Mah (Co-I) Sponsor: MS Society of Canada PI: F Costello, Department of Surgery, University of Calgary 137. 2012-2013 Establishing urinary N-telopeptide reference ranges in Healthy Children in Calgary JK Mah (Co-I) Funding: $49,680 Sponsor: Alberta Children’s Hospital Research Institute PI: C Stoian, Department of Clinical Neurosciences, University of Calgary 138. 2010-2013 The Canadian Neuromuscular Disease Registry JK Mah (Site PI) Funding: $750,000 Sponsor: Marigold Foundation, Jesse Journey, and the Public Health Agency of Canada PI: L Korngut, Department of Clinical Neurosciences, University of Calgary 139. 2012-2013 Suicide Prevention in Canada Youth: Options and Evidence JD McLennan (Co-I) Funding (Total): $100,000 Sponsor: CIHR PI: K Bennet, McMaster University; A Cheung, University of Toronto 140. 2012-2013 Improving the mental health of Canadian children and adolescents: A research synthesis JD McLennan (Co-I) Funding (Total): $100,000 Sponsor: CIHR

PI: K Bennet & M Boyle, McMaster University 141. 2006-2014 Steroid-associated Osteoporosis in the Pediatric Population P Miettunen (Site-PI) Funding (total): $3,733,300 Sponsor: CIHR 142. 2011-2013 Can we foresee which children will have a favorable recovery following a mild traumatic brain injury and which will have persistent post-concussion symptoms? A study to refine a clinical prediction rule, the 4C Tool A Mikrogianakis (Site Co-PI), K Barlow (Co-PI) Funding (Total): $47,780 Sponsor: Alberta Children’s Hospital Foundation 143. 2011-2013 Continuous Quality Improvement Pediatric Critical Care Transport Database Project A Mikrogianakis (Site) Co-PI, S Caron (Chief Applicant) Funding (Total): $12,000 Sponsor: Research Excellence Support Team, AHS 144. 2010-2015 Equipment to measure drug response in vitro, Celigo Automated Cell Cytometer (Funding to establish Pre-clinical and biological studies to advance Phase I clinical Trials) Narendran A (PI) Funding (Total): $208,500 Sponsor: Childhood Cancer Collaborative, Alberta Children’s Hospital Foundation 145. 2010-2015 Level I technician to facilitate the analysis of study specimens and to assist with the development of novel therapeutic agents. Salary support and Reagents (Funding to

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Department of Paediatrics | Annual Report 2012

establish biological correlative and preclinical studies to advance Phase I clinical trials) Narendran A (PI) Funding (Total): $355,342 Sponsor: Childhood Cancer Collaborative, Alberta Children’s Hospital Foundation. 146. 2010-2013 Next generation anti-mitotics for treatment of refractory cancer Narendran A (Co-I) Funding (Total): $450,000 Sponsor: NSERC and CIHR PI: Shrimer D 147. 2011-2013 Binding studies of platinum-based anticancer drugs to plasma proteins to gain new insight into their toxic side-effects in pediatric cancer patients (Bridge and Pilot Funding) Narendran A (Co-I) Funding (Total): $50,000 Sponsor: Alberta Innovates Health Solutions PI: Gailer J, Department of Chemistry, University of Calgary 148. 2011-2013 Preclinical studies and feasibility evaluation of polo-like-kinase (PLK) inhibitors for the treatment of refractory pediatric leukemia Narendran A (PI) Funding (Total): $30,000 Sponsor: C17 Children’s Cancer and Blood Disorders (Consortium of the 17 Canadian Hospitals that care for pediatric hematology and oncology patients) 149. 2012 Novel targets for therapeutics in pediatric neurocutaneous melanosis. (Summer Studentship) Narendran A (PI) Funding (Total): $6,000 Sponsor: Alberta Innovates Health Solutions

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150. 2012 In vitro studies of zoledronic acid as a novel treatment for relapsing and refractory osteosarcoma in children (Summer Studentship) Narendran A (PI) Funding (Total): $6,000 Sponsor: Alberta Innovates Health Solutions 151. 2012 Mechanisms responsible for the growth of the atypical teratoid rhabdoid tumour of the central nervous system (CNS AT/RT) in children Narendran A (PI) Funding (Total) $6,000 Sponsor: The Markin Undergraduate Student Research Program

Annual Report 2012 | Department of Paediatrics

155. 2012-14 Is salivary cortisol useful in predicting isol for the diagnosis of adrenal insufficiency in preterm neonates of ≤ 32 weeks gestation? D Pacaud (PI) H Amin (Co-I) Funding (Total): $ 49,981 Sponsorship: Alberta Children’s Hospital Research Institute (ACHRI) 156. 2009-2013 Corneal Confocal Microscopy to detect Diabetic Neuropathy in Children D Pacaud (Co-PI), JK Mah (co-PI) Funding: $362,358 Sponsor: Juvenile Diabetes Research Foundation

152. 2010-2012 Health Impact of Unexpected School Closure A Nettel-Aguirre (Co-PI) Funding: $197,384 Sponsor: Canadian Institutes of Health Research

157. 2006-12 Efficacy and safety of targeting lower arterial oxygen saturations to reduce oxygen toxicity and oxidative strss in very preterm infants: Canadian Oxygen Trial R Sauve (Site PI) Y Rabi (Co-I) Funding (Total): $ 3,691,500 Sponsor: Canadian Institutes of Health Research (CIHR) PI: Barbara Schmidt, McMaster University

153. 2012- ongoing Determining the Effect of a Targeted Video on Satisfaction with Transition from Pediatric to Adult Endocrine Care for Patients with Type 1 Diabetes Mellitus D Pacaud (PI), J Ho (Co-I), K Winston (Co-I) Funding (Total): $2,199 Sponsor: Alberta Children’s Hospital Foundation

158. 2009 – ongoing Pilot randomized controlled trial of vaginal progesterone to prevent preterm birth in women with threatened preterm labour Y Rabi (Co-I) Funding (Total): $44,464 Sponsor: Alberta Children’s Hospital Foundation PI: S Wood, Departments of Obstetrics & Gynecology, University of Calgary

154. 2008-2011 Apo-B and ApoB/ApoA-1 Ratio: Cardiovascular Risk Markers in Children with Type 1 Diabetes D Pacaud (PI), J Ho (Co-I) Funding (Total): $2,914 Sponsor: Alberta Children’s Hospital Foundation

159. 2011-2012 Physiological Changes in L-(+)-BetaHydrobutyrate Levels in Medically Refractory Epileptic Patients Treated with an Anticonvulsant Ketogenic Diet Rho JM (PI) Funding: $41,956 Sponsor: Alberta Children’s Hospital Research Institute for Child and Maternal Health (ACHRI)

160. 2012-2017 Modulation of Brain-Specific ATP-Sensitive Potassium Channels by Physiological Stereoisomers of the Primary Ketone Body Beta-Hydroxybutyrate Rho JM (PI) Funding: $712,613 Sponsor: Canadian Institutes for Health Research (CIHR) 161. 2010-2015 Metabolic Mechanisms of Functional Neuroprotection in Epileptic Brain Rho JM (Co-PI) Funding: $2,308,750 Sponsor: National Institutes of Health (NIH), National Institute of Neurological Disorders and Stroke Co-PI: Do Young Kim, Barrow Neurological Institute 162. 2010-2013 Multiple Sclerosis-Induced Impairment of Learning and Memory Rho JM (Co-I) Funding: $187,500 Sponsor: Arizona Biomedical Research Commission (USA) PI: Do Young Kim, Barrow Neurological Institute 163. 2011 The mTOR Signaling Pathway in Autism Spectrum Disorder Rho JM (PI) Funding: $4,000 Sponsor: CIHR Training Program, Summer Studentship (Ms. Mariam Narous) 164. 2012 Alterations in mTOR Signaling in the Genetic BTBR Mouse model of Autism Spectrum Disorder Rho JM (PI) Funding: $4,000 Sponsor: CIHR Training Program, Summer Studentship (Ms. Mariam Narous)

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Department of Paediatrics | Annual Report 2012

165. 2012-2013 The Neuroprotective Effects of the Ketogenic Diet in a Co-mordid Animal Model of Epilepsy and Autism Rho JM (PI) Funding: $40,000 Sponsor: CIHR Training Program Postdoctoral Fellowship (Younghee Ahn, PhD) 166. 2009-2012 Health outcomes during transition to adulthood in pediatric patients with endstage renal disease S Samuel (PI) Funding (Total): $46,112 Sponsor: ACH Foundation 167. 2010-2012 End-stage renal disease in Canadian Aboriginal children S Samuel (PI) Funding (Total): $49,556 Sponsor: ACH Foundation 168. 2009 - ongoing Effect of physician alternate payment plans on the completeness and validity of administrative data S Samuel (Co-I) Funding (Total): $205,139 Sponsor: CIHR PI: H Quan, Department of Community Health Sciences, University of Calgary

171. 2011 - ongoing The Canadian Kidney Knowledge Translation and Generation Network (CANN-NET) S Samuel (Co-I) Funding (Total): $543,542 Sponsor: CIHR PI: B Manns, Departments of Medicine and Community Health Sciences, University of Calgary 172. 2010-2012 Health care utilization during transition from childhood to adulthood in pediatric endstage renal disease patients S Samuel (PI), A Nettel-Aguirre (Co-I) Funding: $100,000 Sponsor: Kidney Foundation of Canada 173. 2008-13 CIHR Team in Maternal-Infant Care – Translating knowledge into improved care R Sauve (Site PI) Funding (Total): $ 5,177,000 Sponsor: CIHR PI: S. Lee, University of Toronto 174. 2010-15 CAP 11 years outcomes R Sauve (Site PI) Funding (Total): $2,038,135.00 Sponsor: CIHR PI: B Schmidt, McMaster University

169. 2011-2013 Childhood Social Factors in Development – The CHILDSOC Project S Samuel (Co-I) Funding (Total): $98,984 Sponsor: CIHR PI: L Roos, University of Manitoba

175. 2012-2013 Optimizing Outcomes of Children who Require Live-saving Complex Interventions R Sauve (Site PI) Funding (Total): $10,000 Sponsor: AIHS PI: CMT Robertson, University of Alberta

170. 2011-2014 Screening for markers of kidney disease among Aboriginal children and youth: A pilot project S Samuel (PI) Funding (Total): $18,800 Sponsor: University of Calgary

176. 2012-2013 Pharmacogenetics of juvenile idiopathic arthritis and juvenile dermatomyositis – The influence of polymorphisms in genes of enzymes involved in metabolism on the efficacy and toxicity of methotrexate H Schmeling (PI), P Miettunen (Co-I),

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Annual Report 2012 | Department of Paediatrics

N Johnson (Co-I) Funding (total): $45,217 Sponsor: Alberta Children’s Hospital Foundation 177. 2010-2013 Pharmacogenetics of juvenile idiopathic arthritis – A genome wide association study on the efficacy and toxicity of methotrexate therapy. H Schmeling (PI), P Miettunen (Co-I), N Johnson (Co-I) Funding (total): $240,000 Sponsor: Networks of Centres of Excellence/Canadian Arthritis Network 178. 2006-2012 Determinants of risk and outcome in inflammatory arthritis - New Emerging Team Grant in Clinical Autoimmunity: A multicenter National Study H Schmeling (Site-PI), P Miettunen (Co-I), N Johnson (Site-Co-I) Funding (total): $2000,000 Sponsor: CIHR PI: Katherine Siminovitch, University of Toronto 179. 2008-2013 Impact of (ACoRN) Acute Care of at Risk Newborn Education Program in Rural China N Singhal (PI) Funding (Total): $180,000 Sponsor: China joint Canadian Institutes of Health Research

of central line associated blood stream infection (CLA-BSI) in the neonates admitted to neonatal intensive care unit (NICU) A Soraisham (PI) Funding (Total): $3,000 Sponsor: Alberta Children’s Hospital Foundation 182. 2010-2012 Histological chorioamnionitis and bronchopulmonary dysplasia in preterm infants: A retrospective cohort study A Soraisham (PI), R. Sauve (Co-I) Funding (Total): $1,490 Sponsor: Alberta Children’s Hospital Foundation 183. 2009-2012 Chorioamnionitis and neurodevelopmental outcome A Soraisham (PI) Funding: $5,797 Sponsor: Alberta Children’s Hospital Start Up Fund 184. 2008-2012 An escalating dose of indomethacin for the treatment of persistent patent ductus arteriosus (PDA) in preterm infants – a randomized pilot study. A Soraisham (PI), Amin H (Co-I), Singhal N (Co-I) Funding (Total): $16,175 Sponsor: Alberta Children’s Hospital Foundation

180. 2012-2014 A family integrated care model for neonatal intensive care units A Soraisham (Co-I) Funding (Total): $ 349,982 Sponsor: CIHR PI: S Lee, University of Toronto

185. 2010-13 A Network for Accessible, Sustainable, and Collaborative Research in Pediatric Palliative Care SL Spicer (Site PI) Funding: (Total) $375 328 Sponsor: CIHR PI: H Siden, University of British Columbia

181. 2011-2013 Impact of Central Line Bundle (a quality improvement initiative) on the incidence

186. 2008-13 Charting the Territory: Determining and Documenting Trajectories for Families

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Department of Paediatrics | Annual Report 2012

Where a Child Has a Life-Threatening Condition SL Spicer (Site PI), Robin Casey (Co-I), Jean Mah (Co-I), Francois Bernier (Co-I) Funding (Site): $20,594 per annum Sponsor: CIHR PI: H Siden, University of British Columbia 187. 2012 Establishing priorities for patient safety research in the emergency department setting Stang A.S. (Co-PI), Plint, A. Funding (Total): $24,965 Sponsor: Canadian Institutes of Health Research (CIHR) 188. 2011- ongoing Impact of Growth Hormone on Adult Bone Quality in Turner Syndrome: A Study Using High Resolution Peripheral Quantitative CT D Stephure (PI) Funding (Total): $12,481 Sponsor: Alberta Children’s Hospital Foundation 189. 2009-2017 Trial to Reduce Insulin-Dependent Diabetes Mellitus in the Genetically at Risk (TRIGR) D Stephure (PI), D Pacaud (Co-I) Funding (Total): $615,150 Sponsor: Canadian Institute of Health Research/John Robarts Research Institute PI: John Dupre, John Robarts Research Institute 190. 2009-2013 Steroid-Induced Osteoporosis in the Pediatric Population: Canadian Incidence Study (Co-Applicant) D Stephure (PI) Funding (Total): $302,959 Sponsor: Canadian Institute of Health Research

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Annual Report 2012 | Department of Paediatrics

191. 2012-2013 Establishing N-Telopeptide Reference Ranges in Health Children in Calgary C Stoian (PI) Funding: $44,000 Sponsor: Alberta Children’s Hospital Research Center

197. 2009-2012 Embryonic kidney development and paediatric renal disease J Tee (PI) Funding (Total): $250,000 Sponsor: Alberta Children’s Hospital Foundation

192. 2011-2012 Screening for psychosocial distress in pediatric cancer patients and their families D Strother (PI), D Dewey (Co-I), F Schulte (Co-I) Funding (Total): $37,333 Sponsor: Alberta Children’s Hospital Foundation

198. 2011-2012 MicroRNAs regulate the embryonic development of Polycystic Kidney Disease J Tee (PI) Funding (Total): $ 18,000 Sponsor: University of Calgary – Research Seed Grant

193. 2011-2013 Assessing the efficacy of a psychosocial intervention program for siblings of children with cancer Strother D (Co-I) Funding (Total) $197,684 Sponsor: C17 Research Network for Children’s Cancer and Blood Disorders PI: M Barrera, University of Toronto 194. 2011-2013 A randomized control trial to evaluate the efficacy of a social skills intervention group for childhood survivors of brain cancer Strother D (PI) Funding (Total): $566,969 Sponsor: Canadian Cancer Society Research Institute 195. 2011-2014 MicroRNAs in the Developing Kidney J Tee (PI) Funding (Total): $20,000 Sponsor: ACHRI 196. 2013-2015 MicroRNAs regulate the embryonic development of polycystic kidney disease J Tee (PI) Funding (Total): $150,000 Sponsor: March of Dimes Basil O’Connor Starter Scholar Research Award

199. 2011 Genetic and phenotypic characterization of a novel model for Polycystic Kidney Disease: the (Pkd1+/flox;HoxB7-Cre) mouse J Tee (Co-I) Funding (Total): $4,000 Sponsor: University of Calgary – O’Brien Centre Summer Studentship 200. 2011 MicroRNAs regulate ureteric bud outgrowth from the Wolffian duct J Tee (Co-I) Funding (Total): $4,000 Sponsor: University of Calgary – O’Brien Centre Summer Studentship 201. 2012 Characterization of a novel model for ADPKD: the Pkd1(+/-)HoxB7Cre mouse J Tee (PI) Funding (Total): $5,000 Sponsor: Marking Undergraduate Research Program Award (USRP) – University of Calgary 202. 2012 MicroRNAs regulate of GDNF-dependent and independent Wofflian duct budding J Tee (PI) Funding (Total): $5,200 Sponsor: University of Calgary – O’Brien Centre Summer Studentship

203. 2011-2012 Diagnosis and Management of Appendicitis at Canadian Pediatric Emergency Departments Thompson GC (PI) for the PERC Appendicitis Group. Funding (Total): $15,624 Sponsor: University of Calgary Seed Grant 204. 2012 Test Characteristics of the Alvarado score, the Pediatric Appendicitis Score and the Lintula score with Exclusion of Laboratory Values Thompson GC (PI), Khanafer I, Brindle M, Eccles R Funding (Total): $3,000 Sponsor: Alberta Children’s Hospital Foundation Small Grant 205. 2011-2012 Appendicitis in the Canadian Pediatric Population: An Analysis using National Administrative Data Thompson GC (PI) Kwong S Funding (Total): $3,000 Sponsor: Alberta Children’s Hospital Foundation Small Grant 206. 2011- 2012 Effectiveness and Safety of Intravenous Atropine Therapy for the Prevention of Adverse Events in Pediatric Patients Undergoing Intubation: A Systematic Review Thompson GC (PI), Wilmott A, Lang E, Wakai A, O’Sullivan R Funding (Total): $5,000 Sponsor: Rocky Mountain Emergency Services Grant 207. 2010-2014 Alberta Sepsis Network Thompson GC (Site lead), Sauve R (Co-I) Funding (Total): $5,000,000 team grant Sponsor: Alberta Innovates – Health Solutions Team Leads: Doig C, Department of Critical Care Medicine, University of Calgary; Joffe A, University of Alberta; Kubes P,

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Department of Paediatrics | Annual Report 2012

Department of Physiology and Biophysics, University of Calgary 208. 2012-2013 Risk Factors for Early Language Delay S Tough (PI), B Collisson, S Graham, S McDonald, J Preston, D Bateman, J Evans, C Zwicker, M Jev, M Cutler Funding: $40,000 Sponsor: Alberta Centre for Child, Family & Community Research 209. 2009 – ongoing An evaluation of nephrogenesis in premature infants and the effect of Indomethacin on Post-natal kidney development A Wade (PI) Funding(Total): $44,000 Sponsor: ACH Foundation 210. 2008 – ongoing Nutritional status of tube-fed children with neurodevelopmental disabilities A Wade (Co-I) Funding(Total): $10,000 Sponsor: ACH Foundation 211. 2010 – ongoing Research into kidney development A Wade (PI) Funding(Total): $123,098 Sponsor: AHS – Calgary 212. 2003-2012 Immunogenicity and safety of influenza vaccination in children with inflammatory bowel disease I Wrobel (PI) Funding: $3,007 Sponsor: Alberta Children’s Hospital Fund 213. 2012 Pediatric IBD fund I Wrobel (PI) Funding: $1,120.45 Sponsor: Pediatric IBD Education Fund 214. 2012 Western Alliance IBD Project

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I Wrobel (PI) Funding: $3,731.44 Sponsor: Pediatric IBD Education Fund 215. 2012 IBD Research Support I Wrobel (PI) Funding: $5,484.55 Sponsor: Department of Pediatrics 216. 2012 The Role of GWAS identified I Wrobel (PI) Funding: $3,363.60 Sponsor: Cedars-Sinai Medical Centre 217. 2012 Title: A Multidisciplinary Human Study on the Genetic, Environmental and Microbial Interactions that Cause Inflammatory Bowel Disease I Wrobel (Co-PI), R Panaccione Funding: $14,850 Sponsor: Crohn’s & Colitis Foundation of Canada 218. 2003-2013 Title: The Epidemiology of Pediatric IBD in the Western Region of North America I Wrobel (PI), M Dubinsky Funding: $900 Sponsor: Cedars Sinai Medical Centre 219. 2009-2013 Profile of cytokines and angiogenic factors in preeclampsia and pregnant women who smoke K Yusuf (PI), M Kamaluddeen (Co-I) Funding (Total): $45,000 Sponsor: Calgary Health Region (CHR), Perinatal Funding Competition 220. 2009-2013 A study of endothelial progenitor cells and factors affecting their levels in pregnant women who smoke and preeclampsia K Yusuf Funding (Total): $30,000 Sponsor: Alberta Children’s Hospital Research Institute (ACHRI)

Annual Report 2012 | Department of Paediatrics

221. 2009-2013 Is Pregnancy Induced Hypertension a Risk Factor for the Development of Bronchopulmonary Dysplasia? K Yusuf (PI), A Akierman (Co-I), N Soliman (Co-I) Funding (Total): $2,550 Sponsor: Alberta Children’s Hospital Foundation, Alberta Children’s Hospital Research Institute 222. 2010-2012 Oxidant and anti-oxidant levels in preterm infants before and after a blood transfusion K Yusuf (PI), A Akierman (Co-I), R Krause (Co-I) Funding (Total): $43,554 Sponsor: Alberta Children’s Hospital Foundation, Alberta Children’s Hospital Research Institute 223. 2011-2012 Umbilical cord blood levels of angiogenic and antiangiogenic factors and risk of bronchopulmonary dysplasia in preterm neonates K Yusuf (PI) Funding (Total): $25,000 Sponsor: Angela Jone Memorial Clinical Research Award – The Lung Association 224. 2011-2012 Umbilical cord blood levels of angiogenic and anti-angiogenic factors and risk of retinopathy of prematurity K Yusuf (PI) Funding (Total): $ 20,259 Sponsor: The Lions Sight Center Fund 225. 2011-2012 Can changes in pulmonary function after a loading dose of caffeine predict extubation outcome in preterm infants? K Yusuf (PI) Funding (Total): $3,000 Sponsor: Alberta Children’s Hospital Foundation, Alberta Children’s Hospital Research Institute

Other Funding: 1. 2012 A double-blind, placebo-controlled, randomized study to evaluate the safety and therapeutic effects of Sapropterin, Dihydrochloride on neuropsychiatric symptoms in subjects with Phenylketonuria (PKU ASCEND) R Casey (PI) A Khan (Co-I) Funding: $91,000 Sponsor: Biomarin Pharmaceuticals 2. 2011-2014 A Multicenter Open-label Protocol to Observe the Safety ofr Peplagal (agalsidase alpha) Enzyme Replacement Therapy in Canadian Patients with Fabry Disease R Casey (PI) Funding: $75,000 Sponsor: Shire Human Genetic Therapies, Inc. 3. 2012 A Phase IV Study of Alternate Dosing Regimens of Replagal for Canadian Patients with Fabry Disease R Casey (PI) Funding: $18,400 Sponsor: Shire 4. 2012 A Randomized, Double-Blind, Pilot Study of the Safety and Physiological Effects of Two Doses of BMN-110 in Patients with Mucopolysaccharidosis IVA (Morquio A Syndrome) R Casey (PI) Funding: $96,600.00 Sponsor Biomarin 5. 2009- ongoing A Prospective, Open-Label, NonRandomized, Multi-Center Study to Investigate the Safety and Tolerability of Voriconazole as Primary Therapy for Treatment of Invasive Aspergillosis and Molds such as Scedosporium or

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Fusarium Species in Pediatric Patients (Protocol A1501080) R Chawla (PI) Funding (total) $49,790 Sponsor: Pfizer Canada Inc. 6. 2012 Serum Infliximab levels and pharmacokinetics following infliximab dose for induction of remission in children with moderate to severely-active ulcerative J deBruyn (PI) Funding: $375,000 Sponsor: Future Leaders in IBD (Janssen Inc) & Prometheus 7. 2012 Infliximab IBD Influenza Vaccine Study: Effect of Influenza Vaccination Timing on Immune Response in Patients with Inflammatory Bowel Disease on Infliximab J deBruyn (PI) Funding: $107,006.40 Sponsor: Janssen Inc. 8. 2010 - ongoing Are there specific Electroencephalogram changes in children with chronic renal failure that predict cerebral function? L Hamiwka (PI) Funding(Total):$17,200 Sponsor: EMD Serono Canada, AHFMR Summer studentship, PURE 9. 2010-2014 Inhaled Nitric Oxide for the Prevention of Bronchopulmonary Dysplasia in Preterm Infants Requiring Mechanical Ventilation or Positive Pressure Support on Day 5-14 after Birth SU Hasan (Site PI) Funding (Total): $805,609 Sponsor: INO Therapeutics/Ikaria PI: Dr. James Baldasserre 10. 2012- ongoing A Multicentre, Randomized, Double-blind, Placebo-controlled study to Evaluate the Efficacy and Safety of Saxagliptin (BMS-

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477118) in Combination with Metformin IR or Metformin XR in Pediatric Patients with Type 2 Diabetes who have Inadequate Glycemic Control on Metformin J Ho (Site-PI), D Pacaud (Co-I), C. Huang (Co-I), R. Perry (Co-I) Funding (Total): $14,365.52 per patient Sponsor: Bristol-Meyers Squibb Canada Inc. Study Director: Pamela Zee, MD 11. 2011- ongoing A Multicentre, Randomized, Double-blind, Placebo-controlled study to Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of Saxagliptin (BMS477118) as Monotherapy in Pediatric Patients with Type 2 Diabetes J Ho (Site-PI), D Pacaud (Co-I), C. Huang (Co-I), R. Perry (Co-I) Funding (Total): $14,365.52 per patient Sponsor: Bristol-Meyers Squibb Canada Inc., Alberta Children’s Hospital Foundation 12. 2011-2013 CASPER-PCV (Calgary Area Streptococcus Pneumonia Epidemiology Research Pneumococcal Conjugate Vaccine) Study IV_Continuation of Surveillance and Analysis of Invasive Pneumococcal Disease (IPD) in Canada. JD Kellner (PI), OG Vanderkooi (Co-I) Funding (total) $746,518 Pfizer Canada Inc. 13. 2010-2012 CASPER-PCV (Calgary Area Streptococcus pneumoniae Epidemiology Research – Pneumococcal Conjugate Vaccine) Study: Continuation of Evaluation of Trends in Nasopharyngeal Colonization in Canada. JD Kellner (PI), O Vanderkooi (Co-I) Funding (total) $123,736 Sponsor: Pfizer Canada Inc. 14. 2012 Title: Open, Prospective, HistoricControlled, Multicenter study to Evaluate the Safety and Efficacy of Infusion of Liver

Annual Report 2012 | Department of Paediatrics

Cell Suspension (HHLivC) in Children with Urea Cycle Disorders A Khan, S R Martin (Co-I) Funding: $166,000/patient Sponsor: Cytonet 15. 2012-2013 Open, Prospective, Historic-Controlled, Multicenter Study to Evaluate the Safety and Efficancy of Infusion of Liver Cell Suspension (HHLivC) in Children with Urea Cycle Disorders A Khan (PI) Funding: $525,000 Sponsor: Cytonet 16. 2010-2013 The importance of international travel in the spread of multi-resistant Gram negative bacteria S Kuhn (Co-I), OG Vanderkooi (Co-I) Funding (total) $75,000 Sponsor: Merck & Co. Inc PI: J Pitout, Department of Pathology & Laboratory Medicine, University of Calgary 17. 2012-2014 Canadian Pediatric Society Surveillance study: Periodic fever syndromes P Miettunen (Co-I), H Schmeling (Co-I), N Johnson (Co-I) Funding (total): $40,000 Sponsor: Novartis PI: P Dancey, Memorial University 18. 2010-2012 A randomized, double-blind, placebo controlled, withdrawal study of flare prevention of canakinumab (ACZ885) in patients with Systemic Juvenile Idiopathic Arthritis (SJIA) and active systemic manifestations P Miettunen (Site-PI), H Schmeling (CoI), N Johnson (Co-I) Funding (local): $6,310 Sponsor: Novartis 19. 2010-2012 An open-label extension study of

canakinumab (ACZ885) in patients with Systemic Juvenile Idiopathic Arthritis (SJIA) and active systemic manifestations P Miettunen (Site-PI), H Schmeling (CoI), N Johnson (Co-I) Funding (local): $4,450 Sponsor: Novartis 20. 2010-2012 A randomized, double-blind, placebo controlled, single-dose study to assess the initial efficacy of canakinumab (ACZ885) with respect to the adapted ACR Pediatric 30 criteria in patients with Systemic Juvenile Idiopathic Arthritis (SJIA) and active systemic manifestations P Miettunen (Site-PI), H Schmeling (CoI), N Johnson (Co-I) Funding (local): $6403 Sponsor: Novartis 21. 2010-2012 An open-label study to assess the safety, tolerability and efficacy of canakinumab (ACZ885) in patients aged 4 years or older diagnosed with cryopyrin-associated periodic syndromes in Canada P Miettunen (Site-PI), H Schmeling (CoI), N Johnson (Co-I) Funding (local): $13,299 Sponsor: Novartis 22. 2011-2012 Down syndrome and RSV prevention Mitchell, I (Co-I) Funding: $20,000 Sponsor: Abbott International 23. 2012- ongoing Post-Marketing Surveillance to Monitor the Long-Term Safety and Efficacy of Omnitrope in Infants, Children and Adolescents D Pacaud (PI), J Ho (Co-I), R Perry (Co-I) Funding (Total): $10,615.75 Sponsor: Sandoz 24. 2011- ongoing First Year Growth Response Associated

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Genetic Markers Validation Phase IV OpenLabel Study in Growth Hormone Deficient and Turner Syndrome Pre-Pubertal Children: The PREDICT Pharmacogenetics Validation Study D Pacaud (PI), J Ho (Co-I), R Perry (Co-I) Funding (Total): Patient Recruitment in Progress Sponsor: Merck Serono International Coordinating Investigators: Pierre Chatelain, MD (Lyon, France Université de Lyon); Peter Clayton, MD (Manchester, UK University of Manchester) 25. 2010- ongoing A Canadian, Multi-Centre, Observational Registry to Study Adherence and Long Term Outcomes of Therapy in Pediatric Subjects Using SAIZEN® via Easypod TM Auto-Injector for Growth Hormone Treatment D Pacaud (PI) Funding (Total): $100 per patient Sponsor: EMD Serono Canada Inc. PI: JA VanderMerkin, McMaster Children’s Hospital 26. 2010-2011 A Multicentre, Observational Study of NOVOPen ECHO on Safety and Treatment Satisfaction of Insulin Therapy in Children and Adolescents with Diabetes Mellitus D Pacaud (PI) Funding (Total): $5,369 Sponsor: Novo Nordisk Canada Inc. 27. 2008-2011 A Phase 2/3 Randomized, DoubleBlind, Multicenter, Multinational, 4-arm, Controlled Dose Ranging Study to Evaluate Efficacy and Safety of Teplizumab (MGA031), a Humanized FcR Non-Binding, Anti-CD3 Monoclonal Antibody in Children and Adults with Recent-Onset Type 1 Diabetes Mellitus D Pacaud (Site-PI), J Ho (Co-I), C Huang (Co-I)

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Funding (Total): $56,791 Sponsor: Macrogenics Inc. PI: Keran Herold (Yale University) 28. 2003- ongoing The Genetics and Neuroendocrinology of Short Stature International Study (GeNeSIS) Study B9R-EW-GDFC(a) D Pacaud (PI), D Stephure (Co-I), C Huang (Co-I), J Ho (Co-I), R Perry (Co-I) Funding (Total): $14,050 Sponsor: Eli Lilly Canada Inc. PI: Susan Kirsh, Richmond Research Center 29. 2000- ongoing A Patient Registry to Study the Safety, Management and Treatment of Growth Hormone Deficiency Utilizing Saizen D Pacaud (PI) Funding (Total): $24,940 Sponsor: EMD Serono Canada Inc. PI: Horia Ijacu, EMD Serono 30. 2009-2013 Randomized double-blind, placebo controlled withdrawal trial to evaluate the efficacy and safety of tocilizumab in polyarticular juvenile idiopathic arthritis H Schmeling (Site-PI), P Miettunen (CoI), N Johnson (Co-I) Funding (local): $137,442 Sponsor: Hoffmann-la Roche 31. 2012-2014 A phase I pharmacokinetic and safety study of tocilizumab in patients less than 2 years old H Schmeling (Site-PI), P Miettunen (CoI), N Johnson (Co-I) Funding (local): $22,013 Sponsor: Hoffmann-la Roche 32. 2010- ongoing An International Multicentre, Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Trial of IV Zoledronic Acid Twice Yearly Compared to Placebo in Osteoporotic Children Treated with

Annual Report 2012 | Department of Paediatrics

Glucocorticoids for Chronic Inflammatory Conditions D Stephure (PI) Funding (Total): $59,782 Sponsor: Novartis Pharmaceuticals Canada Inc. PI: Leanne Ward, University of Ottawa 33. 2011-2014 Immunization of Women with Diphtheria and Tetanus Toxoids Combined with Acellular Pertussis (TDaP) during the MidThird Trimester of Pregnancy: an Evaluation of the Potential for Immunological Protection for the Neonate OG Vanderkooi (site PI) JD Kellner (Co-I) SM Kuhn (Co-I) Funding (total) $215,683 Sponsor: Sanofi Canada PI: S Halperin, Dalhousie University

37. 2010-2015 A Randomized, Double-Blind, Parallel-gp study to assess the safety and efficacy of Asacol (1.2 to 4.8g/day) 400mg delayedrelease tablets give 2x daily for 26 weeks to children and adolescents for the Mtce of remissin of Ulcerative Colitis I Wrobel (PI) Funding: $3,460 Sponsor: Warner Chilcott

34. 2012 Bench to Bedside - A Laboratory Approach to Defining Immunity to VaccinePreventable Illnesses OG Vanderkooi (PI), JD Kellner (Co-I) Funding (total) $100,000 Sponsor: Pfizer Canada Inc. (Grant-in-Aid) 35. 2012 IMPACT-Surveillance of Streptococcus pneumoniae serotype 19A in Canadian Children Vanderkooi OG (PI), Kellner JD (Co-I) Funding (total) $18,000 Sponsor: Public Health Agency of Canada /Novartis Canada & Residual Funds 36. 2008-2012 A multi-centre, open-label study of the human anti-TNF monoclonal antibody Adalimumab to evaluate the efficiacy and long-term safety and tolerability of repeat administration of Adaliumumab in pediatric subjects with Crohn’s Disease I Wrobel (PI) Funding: 26,590 Sponsor: Abbott Laboratories

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Annual Report 2012 | Department of Paediatrics

Special Feature

High Impact Publications The ISI Web of KnowlegeSM listed 8336 peer-reviewed journals with impact factors in 2011. Of these, just 220 journals (2.6%) had very high impact factors of 8 or above. In 2011-2012, members of the Department were authors on 19 manuscripts in these journals, 12 of which were in journals with impact factors of 10 or above.

1. Allen H, Flanagan S, Shaw-Smith C, et al (including Ho, J member of International Pancreatic Agenesis Consortium). GATA6 haploinsufficiency causes pancreatic agenesis in humans. Nature Genetics 2011; 44(1):20-22. (Impact factor 35.532) 2. Anderson BH, Kasher PR, Mayer J, et al (including Ferreira P). Mutations in CTC1 encoding conserved telomere maintenance component 1, cause Coats plus. Nature Genetics. 44(3):338-42, 2012. (Impact factor 35.532) 3. Bernier FP, Caluseriu O, Ng S, et al (including Innes AM, Lauzon J, Parboosingh JS). Haploinsufficiency of SF3B4, a component of the pre-mRNA splicesosomal complex, causes Nager syndrome. Am J Hum Genet. 2012 May 4;90(5):925-33. (Impact factor 10.603)

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4. Dhaunchak AS, Becker C, Schulman H, et al (including Canadian Pediatric Demyelinating Disease Group (Mah JK member). Implication of perturbed axoglial apparatus in early pediatric multiple sclerosis. Ann Neurol 2012 May;71(5):60113. (Impact factor 11.089) 5. Doherty D, Chudley AE, Coghlan G, et al (including Innes AM). GPSM2 mutations cause the brain malformations and hearing loss in Chudley-McCullough syndrome. Am J Hum Genet. 2012 Jun 8;90(6):108893. Erratum in: Am J Hum Genet. 2012 Jul 13;91(1):209. (Impact factor 10.603) 6. Emery C, Kang J, Shrier I,et al (including Hagel B, Nettel-Aguirre A). Risk of injury associated with bodychecking experience among youth hockey players. Can Med Assoc J 2011;183(11):1249-56. (Impact factor 8.217) 7. Escolar DM, Zimmerman AL, Bertorini TE, et al (including Mah JK). Pentoxifylline as a Rescue Treatment for Duchenne Muscular Dystrophy: A randomized, double blind clinical trial. Neurology 2012 Mar 20;78(12):904-13. (Impact factor 8.312) 8. Gault EJ, Perry RJ, Cole TJ, et al. The impact of oxandrolone and timing of pubertal induction on final height in Turner Syndrome: a randomized, double-blind, placebo-controlled trial. Brit Med J 2011; 14:342:d1980. (Impact factor 14.093) 9. Greenaway C, Munoz M, Barnett E, et al (including Kuhn S) Evidence-based clinical guidelines for immigrants and refugees. Appendix 3: Measles, Mumps, Rubella, Diphtheria, Tetanus, Pertussis

(DTaP/Tdap) and Polio. Evidence review for newly arriving immigrants and refugees. Can Med Assoc J 2011;183(12):e824-925. (Impact factor 8.217) 10. Greenaway C, Narasiah L, Plourde P, et al (including Kuhn S) Evidence-based clinical guidelines for immigrants and refugees. Appendix 5: Hepatitis B â&#x20AC;&#x201C; Evidence Review for Newly Arriving Immigrants and Refugees. Can Med Assoc J 2011; 183(12):e824-925 (Impact factor 8.217) 11. Hood RL, Lines MA, Nikkel SM, et al (including McLeod DR). Mutations in SRCAP, encoding SNF2-related CREBBP activator protein, cause Floating-Harbor Syndrome. Am J Hum Genet. 2012 Feb 10;90(2):3088-13. (Impact factor 10.603) 12. Huang L, Szymanska K, Jensen VL, et al (including McLeod DR, Bernier FP, Parboosingh JS). TMEM237 is mutated in individuals with a Joubert syndrome related disorder and expands the role of the TMEM family at the ciliary transition zone. Am J Hum Genet 2011 Dec 9;89(6):713-30. (Impact factor 10.603) 13. Joseph KS, Kramer M, Sauve R, et al. International comparisons of perinatal and infant mortality: Influence of definitionbased versus pragmatic birth registration on international comparisons of perinatal and infant mortality: population based retrospective study. Brit Med J. Feb 2012; 26(2): (124-30) (Impact factor 14.093)

LIN28 and OLIG2 as markers of survival and metastatic potential in childhood central nervous system primitive neuroectodermal brain tumours. Lancet Oncology 2012 Aug 13(8):838-48. Epub 2012 Jun 11 5. (Impact factor 23.462) 16. RiviĂ¨re JB, Mirzaa GM, O'Roak BJ, et al (including Innes AM, Lauzon JL). De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes. Nat Genet. 2012 Jun 24;44(8):934-40. (Impact factor 35.532) 17. Samuel SM, Foster BJ, Tonelli MA,et al (including Nettel-Aguirre A). Pediatric Renal Outcomes Canada Group. Dialysis and transplantation among Aboriginal children with kidney failure. Can Med Assoc J 2011;183(10):E665-72. (Impact factor 8.217) 18. Schechter T, Kirton A, Laughlin S, et al. Safety of anticoagulants in children with arterial ischemic stroke. Blood 2012; 119(4):949-56. (Impact factor 9.898) 19. Schmidt B, Anderson PJ, Doyle LW et al (including Caffeine for Apnea of Prematurity (CAP) Trial Investigatotrs (including Dewey D, Sauve RS). Survival without disabilities to 5 years after neonatal caffeine treatment for apnea of prematurity. J Am Med Assoc. 2012 Jan 18;307(3):275-82. (Impact factor 30.026)

14. McCarthy A, Varghese S, Duggan A, et al (including Kuhn S). Evidence-based clinical guidelines for immigrants and refugees. Appendix 9: Malaria: Evidence Review for Newly Arriving Immigrants and Refugees. Can Med Assoc J 2011;183(12): e824-925 (Impact factor 8.217) 15. Picard D, Miller S, Hawkins C, Bouffet E, et al (including Lafay-Cousin L). Integrative genomic analyses identify

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Department of Paediatrics | Annual Report 2012

Annual Report 2012 | Department of Paediatrics

Research Publications Peer Reviewed Manuscripts 1. Abdelwahab, M.G., Fenton, K.E., Preul, M.C., Rho, J.M., Lynch, A., Stafford, P., Scheck, A.C. The ketogenic diet is an effective adjuvant to radiation therapy for the treatment of malignant glioma. PLoS One. 2012;7(5):e36197. 2. Al Awad E, Obaid H, Clark D, Narendran A, Amin H, Lodha A. Hepatoblastoma: A rare cause of nonimmune hydrops in a preterm infant. J Neonatal-Perinatal Medicine 2011; 4(4): 387 – 391. 3. Al Awad E, Obaid H, Mohammad K, Amin H, Lodha A. Staphylococcus aureus sepsis inducing severe hemolysis in Glucose-6-phosphate dehydrogenase deficient preterm infant causing severe neonatal jaundice and kernicterus. J Neonatal-Perinatal Medicine 2011; 4(4): 373-377. 4. Alexander RT, Foster BJ, Tonelli MA, Soo A, Nettel-Aguirre A, Hemmelgarn BR, Samuel SM; of the Pediatric Renal Outcomes Group Canada. Survival and transplantation outcomes of children less than 2 years of age with end-stage renal disease. Pediatr Nephrol. 2012 Oct;27(10):1975-83. doi: 10.1007/s00467012-2195-8. Epub 2012 Jun 7. 5. Allen, H., Flanagan, S., Shaw-Smith, C., DeFranco, E., Akerman, I., Caswell, R., Ferrer, J. GATA6 haploinsufficiency causes pancreatic agenesis in humans., International Pancreatic Agenesis

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Consortium (Ho, J. is a member), Hattersley, A., Ellard, S. Nature Genetics December 2011; 44(1):20-22. 6. Alos, N., Grant, R.M., Ramsay, T., Halton, J., Cummings, E.A., Miettunen, P.M., Abish, S., Atkinson, S., Barr, R., Cabral, D.A., Cairney, E., Couch, R., Dix, D.B., Fernandez, C.V., Hay, J., Israels, S., Laverdière, C., Lentle, B., Lewis, V., Matzinger, M.A., Rodd, C., Shenouda, N., Stein, R., Stephure, D., Taback, S., Wilson, B., Williams, K., Rauch, F., Siminoski, K., and Ward, L.M. and the Canadian STOPP Consortium (D. Stephure is a member). High incidence of vertebral fractures in children with acute lymphoblastic leukemia 12 months after the initiation of therapy. Journal of Clinical Oncology 2012 June. 7. American Academy of Pediatrics – Committee on Adolescence (Pinzon JL., member). Health care for youth in the juvenile justice system. Pediatrics 2011;128(6):1219-1235. doi: 10.1542/ peds.2011-1757. 8. American Academy of Pediatrics – Committee on Adolescence (Pinzon JL., member). Male adolescent sexual and reproductive health care. Pediatrics 2011;128(6):e1658-e1676. doi: 10.1542/ peds.2011-2384. 9. Anderson BH, Kasher PR, Mayer J, Szynkiewicz M, Jenkinson EM, Bhaskar SS, Urquhart JE, Daly SB, Dickerson JE, O'Sullivan J, Leibundgut EO, Muter J. Abdel-Salem GM, Babul-Hirji R, Baxter P, Berger A, Bonafe L, Brunstom-

Hernandez JE, Buckard JA, Chitayat D, Chong WK, Cordelli DM, Ferreira P, Fluss J, Forrest EH, Franzoni E, Garone C, Hammans SR, Houge G, Hughes I, Jacquemont S, Jeannet PY, Jefferson RJ, Kumar R, Kutschke G, Lundberg S, Lourenco CM, Mehta R, Naidu S, Nischal KK, Nunes L, Ounap K, Philippart M, Prabhakar P, Risen SR, Schiffmann R, Soh C, Stephenson JB, Stewart H, Stone J, Tolmie JL, van der Knaap MS, Vieira JP, Vilain CN, Wakeling EL, Wermenbol V, Whitney A, Lovell SC, Meyer S, Livingston JH, Baerlocher GM, Black GC, Rice GI, Crow YJ: Mutations in CTC1 encoding conserved telomere maintenance component 1, cause Coats plus. Nature Genetics. 44(3):338-42, 2012. 10. Bahl R, Martines J, Bhandari N, Biloglav Z, Edmond K, Iyengar S, Kramer M, Lawn JE, Manandhar DS, Mori R, Rasmussen KM, Sachdev HP, Singhal N, Tomlinson M, Victora C, Williams AF, Chan KY, Rudan I. Setting research priorities to reduce global mortality from preterm birth and low birth weight by 2015. J Glob Health 2012 June; 2(1):10403. 11. Banderali U, Belke D, Singh A, Jayanthan A, Giles WR, Narendran A. Curcumin Blocks Kv11.1 (erg) Potassium Current and Slows Proliferation in the Infant Acute Monocytic Leukemia Cell line THP1. Cell Physiol Biochem.; 28(6):1169-80. 2011 12. Banderali U, Jayanthan A, Hoeksma K, Narendran A, Giles, W. Ion channels in pediatric CNS Atypical Teratoid/ Rhabdoid Tumor (AT/RT) cells: potential targets for novel therapeutic agents. J Neurooncol.; 107(1):111-9. 2011 13. Bannister S.L., Hanson J.L., Maloney C.G., Raszka W.V. Jr. Using the student case presentation to enhance diagnositic reasoning. Pediatrics 2011; 128(2):(211-3).

14. Barlow, K. Weight gain after childhood traumatic brain injury. Dev Med Child Neurol 2012;54(7):583. 15. Bedard T, Lowry RB, Sibbald B, Harder JR, Trevenen C, Horobec V, Dyck JD. Congenital heart defect case ascertainment by the Alberta Congenital Anomalies Surveillance System. Birth Defects Res A 2012 94:449-458. doi: 10.1002/bdra.23007. 16. Bedard T, Lowry RB, Sibbald B. ICD10 Coding for Congenital Anomalies: A Canadian Experience. Journal of Registry Management 2012 Volume 39:4-7. 17. B enzies K, Tough S, Edwards N, Mychasiuk R, Donnelly C. Aboriginal children and their caregivers living with low income: outcomes from a two-generation preschool program. Journal of Child and Family Studies 2011;20(3):311-318. 18. Bermejo-Sánchez E, Cuevas L, Amar E, Bakker MK, Bianca S, Bianchi F, Canfield MA, Castilla EE, Clementi M, Cocchi G, Feldkamp ML, Landau D, Leoncini E, Li Z, Lowry RB, Mastroiacovo P, Mutchinick OM, Rissmann A, Ritvanen A, Scarano G, Siffel C, Szabova E, Martínez-Frías ML. Amelia: a multicenter descriptive epidemiologic study in a large dataset from the International Clearinghouse for Birth Defects Surveillance and Research, and overview of the literature. Am J Med Genet C Semin Med Genet. 2011 157:288-304. doi: 10.1002/ajmg.c.30319. 19. Bermejo-Sánchez E, Cuevas L, Amar E, Bianca S, Bianchi F, Botto LD, Canfield MA, Castilla EE, Clementi M, Cocchi G, Landau D, Leoncini E, Li Z, Lowry RB, Mastroiacovo P, Mutchinick OM, Rissmann A, Ritvanen A, Scarano G, Siffel C, Szabova E, Martínez-

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Frías ML. Phocomelia: a worldwide descriptive epidemiologic study in a large series of cases from the International Clearinghouse for Birth Defects Surveillance and Research, and overview of the literature. Am J Med Genet C Semin Med Genet. 2011 157:305-320. doi: 10.1002/ajmg.c.30320. 20. Bernard, T.J., Manco-Johnson, M.J., Lo, W., MacKay, M.T., Ganesan, V., deVeber, G., Goldenberg, N.A., Armstrong-Wells, J., Dowling, M.M., Roach, E.S., Tripputi, M., Fullerton, H.J., Furie, K.L., Benseler, S.M., Jordan, L.C., Kirton, A., Ichord, R. Towards a consensus-based classification of childhood arterial ischemic stroke. Stroke 2011, epub Dec 8. 21. Bernier FP, Caluseriu O, Ng S, Schwartzentruber J, Bucking ham KJ, Innes AM, Jabs EW, Innis JW, Schuette JL, Gorski JL, Byers PH, Andelfinger G, Siu V, Lauzon J, Fernandez BA, McMillin M, Scott RH, Racher H; FORGE Canada Consortium, Majewski J, Nickierson DA, Shendure J, Barnshad MJ, Parboosingh JS. Haploinsufficiency of SF3B4, a component of the pre-mRNA splicesosomal complex, causes Nager syndrome. Am J Hum Genet. 2012 May 4;90(5):925-33. 22. Beslow, L.A., Kasner, S.E., Smith, S.E., Mullen, M.T., Kirschen, M.P., Bastian, R.A., Dowling, M.D., Lo, W., Jordan, L.C., Bernard, T.J., Friedman, N., deVeber, G., Kirton, A., Abraham, L., Licht, D.J., Jawad, A.F., Ellenberg, J.H., Lautenbach, E., Ichord, R.N. Concurrent validity and reliability of retrospective scoring of the Pediatric NIH Stroke Scale. Stroke 2011, epub Nov 10. 23. Bettinger JA, Scheifele DW, Halperin SA, Kellner JD, Vanderkooi OG, Schryvers A, De Serres G, Alcantara J. Evaluation of Meningococcal SerOGroup C

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Conjugate Vaccine Programs in Canadian Children: Interim Analysis. Vaccine 2012;30(27):4023-7. Epub 2012 Apr 23. 24. Blanchard I, Doig CJ, Hagel BE, Anton AR, Zygun DA, Kortbeek JB, Powell DG, Williamson TS, Fick GH, Innes GD. Emergency Medical Services Response Time and Mortality in an Urban Setting. Prehospital Emergency Care 2012;16(1):142-51. 25. Botto LD, Feldkamp ML, Amar E, Carey JC, Castilla EE, Clementi M, Cocchi G, de Walle HE, Halliday J, Leoncini E, Li Z, Lowry RB, Marengo LK, MartínezFrías ML, Merlob P, Morgan M, Muñoz LL, Rissmann A, Ritvanen A, Scarano G, Mastroiacovo P. Acardia: epidemiologic findings and literature review from the International Clearinghouse for Birth Defects Surveillance and Research. Am J Med Genet C Semin Med Genet. 2011 157:262-273. doi: 10.1002/ ajmg.c.30318. 26. Brenner JL, Kabakyenga J, Kyomuhangi T, Wotton KA, Pim C, Ntaro M, Bagenda FN, Gad NR, Godel J, Kayizzi J, McMillan D, Mulogo E, Nettel-Aguirre A, Singhal N. Can volunteer community health workers decrease child morbidity and mortality in southwestern Uganda? An impact evaluation. PLoS ONE 2011; 6(12): e27997. doi:10.1371/journal. pone.0027997. 27. Bretholz A, Doan Q, Lauder G, Cheng A. A Pre and Post Survey of a Web and Simulation-Based Course of Ultrasound-Guided Nerve Blocks for Pediatric Emergency Medicine. Pediatric Emergency Care. 2012; 28:506-509. 28. Bushnik T, Cook JL, Yuzpe AA, Tough S, Collins J. Estimating the prevalence of infertility in Canada. Human Reproduction, 2012 Mar;27(3):738-46.

29. Butzner, JD. Pure oats and the glutenfree diet: are they safe? JPEN J Parenter Enteral Nutr. 2011 Jul: 35 (4): 447-8. 30. Canadian Pediatric Society – Adolescent Health Committee (Elliott AS and Pinzon JL, members). The sexual abuse of young people with a disability or chronic condition. Pediatrics and Child Health 2011;16(6):365. 31. Cantell, M, Crawford, S.G. & Dewey, D. (2012).Daily physical activity in young children and their parents: A descriptive study. Paediatrics and Child Health, 17(3),e21-e25. 32. Cárdenas, J.F., Rho, J.M., Kirton, A. Pediatric stroke. Childs Nerv Syst. 2011;27(9):1375-90. 33. Carney, J.A., Ho, J., Kitsuda, K., Stratakis, C.A., Young, W.F Massive neonatal adrenal enlargement due to cytomegaly, persistence of the transient cortex, and hyperplasia of the permanent cortex: Findings in Cushing Syndrome associated with hemihypertrophy. American Journal of Surgical Pathology October 2012;36(10):1452-1463. 34. Carranza J, Clegg NJ, Moore AJ, Delgado M. Use of Trihexyphenidyl in Children with Cerebral Palsy. Pediatric Neurology 2011;44:202-206. 35. CCMG Ethics and Public Policy Committee, Nelson TN, Armstrong L, Richer J, Evans J, Lauzon J, McGillivray B, Bruyere H, Dougan S. CCMG statement on direct-to-consumer genetic testing. Clin Genet. 2012 Jan;81(1):1-3. 36. Chadha R, Johnson JA, Fruitman D, Cooper SL, Wei XC, Bernier F. A rare case ofcardiac rhabdomyomas in a dizygotic twin pair. J Obstet Gynaecol Can. 2011 Aug;33(8):854-7.

37. Cheng A, Donoghue A, Gilfoyle E, Eppich W. Simulation-based crisis resource management training for pediatric critical care medicine: a review for instructors. Pediatr Crit Care Med. 2012 Mar;13(2):197-203. 38. Chitnis, T., Tenembaum, S., Banwell, B., Krupp, L., Pohl, D., Rostasy, K., Yeh, E.A., Bykova, O., Wassmer, D., Tardieu, M., Kornberg, A., Ghezzi, A. for the IPMSSG. Consensus Statement: Evaluation of new and existing therapeutics for pediatric MS: International Pediatric MS Study Group (IPMSSG) [Mah JK]. Multiple Sclerosis 2012;18(1):116-27. 39. Clark CG, Cantell M, Crawford S, Hamiwka LA. Accelerometry-based physical activity and exercise capacity in pediatric kidney transplant patients. Pediatr Nephrol. 2012 Apr;27(4):659-65. doi: 10.1007/s00467-011-2054-z. Epub 2011 Nov 25. 40. Clemente-Casares, X., Tsai, S., Huang, C., and Santamaria, P. Antigen-specific therapeutic approaches in Type 1 Diabetes. CSH Perspectives in Medicine, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY February 2012: 2. 41. Cole JA, Taylor JS, Hangartner TN, Weinreb NJ, Mistry PK and Khan A. Reducing Selection Bias in Case-Control Studies from Rare Disease Registries. Orphanet Journal of Rare Diseases 2011, 6:61 (12 September 2011). 42. Coo, H., Ouellette-Kuntz, H., Lam, M., Yu, C.T., Dewey, D., Bernier, F.P., Chudley, A. E., Hennessey, P. E., Breitenbach, M.M., Noonan, A. L., Lewis, S., & Holden, J. A. (2012). Factors associated with the age at which children are first diagnosed with an autism spectrum disorder in six regions

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of Canada, Chronic Diseases and Injuries in Canada, 32(2), 84-89. 43. Craighead PC, Anderson RA, Sargent R. Developing leadership within an academic medical Department in Canada: A roadmap for increasing leadership. Healthc Q Vol. 14(3), pp-804.2011 44. Cyr D, McLennan J. Do prenatal service characteristics predict exclusive breast feeding initiation in the Dominican Republic? European Journal of Tropical Medicine and International Health. 2011;Vol 16, Supplement #2.3-027 p 313. 45. Daneman D, Kellner JD. Navigating the Stages of an Academic Career for Pediatricians. Paediatrics & Child Health 2012 June/July;17(6):301-3. 46. Davison K.M., Kaplan B.J. Food intake and blood cholesterol levels of community-based adults with mood disorders. BMC Psychiatry 2012; 12:10. 47. Davison K.M., Kaplan B.J. Vitamin and mineral intakes in adults with mood disorders: Comparisons to nutrition standards and associations with sociodemographic and clinical variables. Journal of the American College of Nutrition 2011; 30:547-558. Davison K.M., Kaplan B.J. Nutrient intakes are correlated with overall psychiatric functioning in adults with mood disorders. Canadian Journal of Psychiatry 2012; 57(2):85–92. 48. Dawrant J.M., Pacaud D., Wade, A., Archer, S., Bamforth, F.J. Informatics of newborn screening for congenital hypothyroidism in Alberta 2005-08: Flow of information from birth to treatment. Canadian Journal of Public Health 2011;102(1):64-7.

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49. de Oliveira C, Brassesco MS, Scrideli CA, Tone LG and Narendran A. MicroRNA Expression and Activity in Pediatric Acute Lymphoblastic Leukemia (ALL). Pediatric Blood and Cancer;. doi: 10.1002/pbc.24167. [Epub ahead of print]. Apr 10, 2012 50. Debruyn JC, Hilsden R, Fonseca K, Russell ML, Kaplan GG, Vanderkooi O, Wrobel I. Immunogenicity and Safety of Influenza Vaccination in Children with Inflammatory Bowel Disease. Inflammatory Bowel Diseases 2012;18(1):25-33. 51. DeForest EK, Thompson GC. Advanced Nursing Directives: Integrating Validated Clinical Scoring Systems into Nursing Care in the Pediatric Emergency Department. Nursing Research and Practice. Volume 2012, Article ID 596393, 1-13. Doi:10.1155/2012/596393 52. Del Bigio, M.R., Chudley, A.E., Sarnat, H.B., Campbell, C., Goobie, S., Chodirker, B.N., Selcen, D. Infantile muscular dystrophy in Canadian aboriginals is an α-B-crystallinopathy. Annals of Neurology 2011;69: 866-871. 53. Dersch-Mills D, Alshaikh B, Akierman A, Yusuf K. Validation of a dosage individualization table for extended interval gentamicin in neonates. Ann Pharmacother, 2012 JulAug;46(7-8):935-42. doi: 10.1345/ aph.1R029. Epub 2012 Jun 26. 54. Dewey D, Creighton DE, Heath J, Wilson B, Anseeuw-Deeks D, Crawford S, Sauve R. Assessment of Developmental Co-ordination Disorders in children born with extremely low birth weight. Dev Neuropsychol. Jul 2011 ;36(1):42-56. 55. Dhaunchak, A.S., Becker, C., Schulman, H., De Faria, O.Jr., Rajasekharan, S.,

Annual Report 2012 | Department of Paediatrics

Banwell, B., Colman, D.R., Bar-Or, A.; Canadian Pediatric Demyelinating Disease Group [Mah JK]. Implication of perturbed axoglial apparatus in early pediatric multiple sclerosis. Ann Neurol 2012 May;71(5):601-13. 56. Doan Q, Singer J, Sheps S, Kissoon T, Wong H, Johnson D, Hooker R. Canadians’ willingness to receive care by Physician Assistants. Can Family Med 2012;58:e459-64 57. Doan Q, Singer J, Sheps S, Wong H, Johnson D, Kissoon N. The role of physician assistants in a pediatric emergency department. A center review and survey. Pediatr Emerg Care 2012; 28:783-8. 58. Doherty D, Chudley AE, Coghlan G, Ishak GE, Innes AM, Lemire EG, Rogers RC, Mhanni AA, Phelps IG, Jones SJ, Zhan SH, Fejes AP, Shahin H, Kanaan M, Akay H, Tekin M; FORGE Canada Consortium, Triggs-Raine B, Zelinski T. GPSM2 mutations cause the brain malformations and hearing loss in Chudley-McCullough syndrome. Am J Hum Genet. 2012 Jun 8;90(6):1088-93. Epub 2012 May 10. Erratum in: Am J Hum Genet. 2012 Jul 13;91(1):209. PubMed PMID: 22578326; PubMed Central PMCID:PMC3370271. 59. Dowling, M., Hynan, L., Lo, W., Licht, D., McClure, C., Yager, J., Dlamini, N., Kirkham, F., deVeber, G., Pavlakis, S. for the International Pediatric Stroke Study Group [Kirton A]. International Paediatric Stroke Study: stroke associated with cardiac disorders. Int J Stroke 2012 doi: 10.1111/j.1747 4949.2012.00925.x.,epub ahead of print. 60. Elliott, A. S., Katzman D. Youth justice and health: An argument against proposed changes to the Youth Criminal Justice Act. Pediatrics and Child Health

2011;16(7):414. Reference No. AH 2011-02. 61. Emery C, Kang J, Shrier I, Goulet C, Hagel B, Benson B, Nettel-Aguirre A, McAllister J, Meeuwisse W. Risk of injury associated with bodychecking experience among youth hockey players. CMAJ 2011;183(11):1249-56. 62. Escolar, D.M., Zimmerman, A.L., Bertorini, T.E., Clemens, P.R., Connolly, A., Mesa, L., Gorni, K., Kornberg, A., Kolski, H., Kuntz, N., Nevo, Y., TesiRocha, C., Nagaraju, K., Rayavarapu, S., Hache, L.P., Mayhew, J.E., Florence, J., Hu, F., Arrieta, A., Henricson, E., Leshner, R.T., Mah, J.K. Pentoxifylline as a Rescue Treatment for Duchenne Muscular Dystrophy: A randomized, double blind clinical trial. Neurology 2012 Mar 20;78(12):904-13. Epub 2012 Mar 7. 63. Farrelly A, McLennan J. Family planning practices and knowledge of mothers of young children in a poor periurban district in the Dominican Republic. European Journal of Tropical Medicine and International Health. 2011;Vol 16, Supplement 1 p 83. 64. Feber, J., Gaboury, I., Ni, A., Alos, N., A urora, S., Bell, L., Blydt-Hansen, T., Clarson, C., Filler, G., Hay, J., Hebert, D., Lentle, B., Matzinger, M., Midgley, J., Moher, D., Pinsk, M., Rauch, F., Rodd, C., Shenouda, N., Siminoski, K., Ward, L.M. and the Canadian STOPP Consortium (D. Stephure is a member). Skeletal findings in children recently initiating glucocorticoids for the treatment of Nephrotic Syndrome. Osteoporosis International 2011. 65. Feldkamp ML, Botto LD, Amar E, Bakker MK, Bermejo-Sánchez E, Bianca S, Canfield MA, Castilla EE, Clementi M, Csaky-Szunyogh M, Leoncini E, Li Z, Lowry RB, Mastroiacovo P, Merlob P,

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Morgan M, Mutchinick OM, Rissmann A, Ritvanen A, Siffel C, Carey JC. Cloacal exstrophy: an epidemiologic study from the International Clearinghouse for Birth Defects Surveillance and Research. Am J Med Genet C Semin Med Genet. 2011 157C(4):333-343. doi: 10.1002/ ajmg.c.30317. 66. Fenton TR, Tough SC, Lyon AW, Eliasziw M, Hanley DA. Causal assessment of dietary acid load and bone disease: A systematic review and meta-analysis applying Hill's epidemiologic criteria for causality. Nutrition Journal 2011;10:41. 67. Forrester L, Collet JC, Mitchell R, Pelude L, Henderson E, Vayalumkal J, Leduc S, Ghahreman S, Weir C, Gravel D; the CNISP Data Quality Working Group, and CNISP participating sites. How reliable are national surveillance data? Findings from an audit of Canadian methicillin-resistant Staphylococcus aureus surveillance data. American Journal of Infection Control 2012;40(2):102-7. 68. Foster BJ, Dahhou M, Zhang X, Platt RW, Samuel SM, Hanley JA. Association between age and graft failure rates in young kidney transplant recipients. Transplantation. 2011 Dec 15;92(11):1237-43. doi: 10.1097/ TP.0b013e31823411d7. 69. Freedman SB, Stewart C, Rumantir M, Thull-Freedman JD. Predictors of Clinically Significant Upper Gastrointestinal Hemorrhage amongst Children with Hematemesis Presenting to an Emergency Department. Journal of Pediatric Gastroenterology, Hepatology and Nutrition 2012; 54(6):737-43. 70. Freedman SB, Tung C, Cho D, Rumantir M, Chan KJ. Time Series Analysis of Ondansetron use in Pediatric Gastroenteritis. Journal of Pediatric

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Gastroenterology, and Nutrition 2012; 54 (3): 381-386 71. Gault, E.J., Perry, R.J., Cole, T.J., Casey, S., Paterson, W.F., Hindmarsh, P.C., Betts, P., Dunger, D.B., Donaldson, M.D.C. The impact of oxandrolone and timing of pubertal induction on final height in Turner Syndrome: a randomized, double-blind, placebocontrolled trial. British Medical Journal 2011; 14:342:d1980. 72. Geller D.H., Pacaud, D., Gordon C.M., Misra, M. State of the Art Review: Emerging Therapies: The Use of insulin sensitizers in the treatment of adolescents with Polycystic Ovary Syndrome (PCOS). International Journal of Pediatric Endocrinology August 2011(1):9. 73. Giesbrecht, G.F., Letourneau, N., Campbell, T., & Kaplan, B. (2012). Affective experience in ecologically relevant contexts is dynamic, and not progressively attenuated during pregnancy. Archives of Women’s Mental Health, 15, 481-485. DOI 10.1007/ s00737-012-0300-4 74. Gilbert N, Fell D, Joseph KS, Liu S, Leon J, Sauve Reg. Temporal trends in Sudden Infant Death Syndrome in Canada 1991 to 2005: contribution of changes of cause of death assignment practices and maternal and infant characteristics. Paediatr Perinat Epidemiol. 2012 Mar;26(2):124-30. 75. Glatstein M, Rozen R, Scolnik D, Rimon A, Grisaru-Soen G, Freedman SB, Reif S. Radiologic Predictors of Hyponatremia in Children Hospitalized with Community Acquired Pneumonia. Pediatric Emergency Care 2012; 28(8):764-766. 76. Goebl A, Ferrier RA, Ferreira P, PintoRojas A, Matshes E, Choy FYM: Gaucher

disease with prenatal onset and perinatal death due to compound heterozygosity for the missense R131C and null RecNciI GBA mutations. Ped. Dev Path. 14(3) 240-243 2011 77. Gracie S, Metcalfe A, Dolan SM, Kehler H, Siever J, Tough S. Utilization of the H1N1 and seasonal flu vaccines by pregnant women during a pandemic flu season. Journal of Obstetrics and Gynaecology Canada. 2011;33(2):127133. 78. Grant EC, Grant VJ, Bhanji F, Duff JP, Cheng A, Lockyer JM. The development and assessment of an evaluation tool for pediatric resident competence in leading simulated pediatric resuscitations. Resuscitation 2012;83(7):887-93. Epub 2012 Jan 28. 79. Greenaway C, Munoz M, Barnett E, Sandoe A, Ueffing E, Pottie K, Kuhn S, Keystone J. Evidence-based clinical guidelines for immigrants and refugees. Appendix 3: Measles, Mumps, Rubella, Diphtheria, Tetanus, Pertussis (DTaP/ Tdap) and Polio. Evidence review for newly arriving immigrants and refugees. CMAJ 2011;183(12):e824-925 80. Greenaway C, Narasiah L, Plourde P, Ueffing E, Deschenes M, Wong D, Kuhn S, Heathcote J. Evidence-based clinical guidelines for immigrants and refugees. Appendix 5: Hepatitis B – Evidence Review for Newly Arriving Immigrants and Refugees. CMAJ 2011;183(12):e824925 81. Grimbly C, Rennebohm R, Fruitman DS. Clinician’s Corner: Chest Pain in an Adolescent. Paediatr Child Health. 2012 Jan;17(1):21-3. 82. Grisaru, S., Watson-Jarvis, K., McKenna, C.M., Ho, J., Harder, J.R., Trussell, R.A. Development of simple

tool for diagnosis and initial approach to hypertension and pre-hypertension in children and youth. Open Journal of Pediatrics April 2012;2:106-110. 83. Guilcher GMT, Rizutti FA, Lewis VA, Stewart DA. Single-agent high-dose melphalan followed by auto HSCT for relapsed and refractory hodgkin lymphoma in children and adolescents. Bone Marrow Transplant. 2012; 47: 395-8. 84. Gupta R., Pinzon JL. Gambling in children and adolescents. Pediatrics and Child Health 2012;17(5):263-264. http:// www.cps.ca/english/statements/AM/ AH12-02.htm 85. Guttman OR, Roberts EA, Schreiber RA, Barker CC, Ng VL, and the Canadian Pediatric Hepatology Research Group. ( Butzner JD, Wrobel I, S Martin are members of the Canadian Pediatric Hepatology Research Group) Biliary atresia with associated structural malformations in Canadian infants: Liver Int, 2011 Nov: 31 (10): 1485-1493. 86. Hamiwka LD, Hamiwka LA, Sherman EM, Wirrell E. Social skills in children with epilepsy: how do they compare to healthy and chronic disease controls? Epilepsy Behav. 2011 Jul;21(3):238-41. doi: 10.1016/j.yebeh.2011.03.033. 87. Harabor A, Fruitman D. Comparison between a suprasternal or high parasternal approach and an abdominal approach for measuring superior vena cava Doppler velocity in neonates. J Ultrasound Med. 2012 Dec;31(12):1901-7. 88. Hartman, A.L., Rho, J.M. Beyond Epilepsy: Ketogenic Diet Use in Other Disease States. In: Dietary Treatment of Epilepsy, Neal E (Ed.), Oxford University Press, 2012.

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89. Hartman, A.L., Rho, J.M. The Biochemical Basis of Dietary Therapies for Neurological Disorders. In: Dietary Treatment of Epilepsy, Neal E (Ed.), Oxford University Press, 2012. 90. Hasan SU, Yusuf K. Rat homologues to the human post neonatal period: models for vulnerability to the Sudden Infant Death Syndrome. Pediatr Pulmonol. Jul 2012; 47(7): 731. 91. Ho J, Huang C, Nettel-Aguirre A, Pacaud D. Insulin detemir in a twice daily insulin regimen versus a three times daily insulin regimen in the treatment of type 1 diabetes in children: A pilot randomized controlled trial. Int J Pediatr Endocrinol 2011;(1):15. 92. Ho J, Lewis V, Guilcher GMT, Stephure DK, Pacaud D. Endocrine complications following pediatric bone marrow transplantation. J PediatrEndocrinol Metab. 2011; 24: 327332. 93. Ho J, Panagiotopoulos C, McCrindle B, Grisaru S, Pringsheim T; The Canadian Alliance for Monitoring Effectiveness and Safety of Antipsychotics in Children (CAMESA) guideline group. Management recommendations for metabolic complications associated withsecondgeneration antipsychotic use in children and youth. Paediatr Child Health. 2011 Nov;16(9):575-580. 94. Hoeksema KA, Jayanthan A, Cooper T, Gore L, Trippett T, Boklan J, Arceci RJ, Narendran A. Systematic in-vitro evaluation of the NCI/NIH Developmental Therapeutics Program Approved Oncology Drug Set for the identification of a candidate drug repertoire for MLLrearranged leukemia. Onco Targets Ther.; 4:149-68. 2011

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95. Hon KL, Leung AK. Neonatal lupus erythematosus. Autoimmune Diseases 2012;2012: 301274. 96. Hon KL, Leung AK. Use of ceramides and related products for childhood-onset eczema. Recent 97. Hood RL, Lines MA, Nikkel SM, Schwartzentruber J, Beaulieu C, Nowaczyk MF, Allanson J, Kim CA, Wieczoek D, Moilanen JS, Lacombe D, Gillessen-Kaesbach G, Whiteford ML, Quaio CR, Gomy I, Bertola DR, Albrecht B, Platzer K, McGillivray G, Zou R, McLeod DR, Chudley AE, Chodirker BN, Marcadier J; FORGE Canada Consortium, Majewski J. Bulman DE, White SM, Boycott KM. Mutations in SRCAP, encoding SNF2-related CREBBP activator protein, cause Floating-Harbor Syndrome. Am J Hum Genet. 2012 Feb 10;90(2):3088-13. Epub 2012 Jan 19. 98. Howlett A, Ohlsson A, Plakkal N. Inositol for respiratory distress syndrome in preterm infants. Cochrane Database Syst Rev. 2012 Mar 14;3:CD000366. 99. Hoy NY, Leung AK, Metelitsa AI, Adams S. New concepts in median nail dystrophy, onychomycosis and handfoot-and-mouth disease nail pathology. Dermatology 2012;2012;68163. 100. H uang L, Szymanska K, Jensen VL, Janecke AR, Innes AM, Davis EE, Frosk P, Li C, Willer JR, Chodirker BN, Greenberg CR, McLeod DR, Bernier FP, Chudley AE, Műller T, Shboul M, Logan CV, Loucks CM, Beaulieu CL, Bowie RV, Bell SM, Adkiins J, Zuniga FI, Ross KD, Wang J, Ban MR, Becker C, Nűrnberg P, Douglas S, Craft CM, Akimenko MA, Hegele RA, Ober C, Utermann G, Boiz HJ, Bulman DE, Katsanis N, Blacque OE, Doherty D, Parboosing JS, Leroux MR, Johnson

Annual Report 2012 | Department of Paediatrics

CA, Boycott KM. TMEM237 is mutated in individuals with a Joubert syndrome related disorder and expands the role of the TMEM family at the ciliary transition zone. Am J Hum Genet 2011 Dec 9;89(6):713-30. 101. Huculak S, McLennan JD, Bordin IA. Exposure to violence in incarcerated youth from the city of São Paulo. Rev Bras Psiquiatr. 2011;33(3): 275-282. 102. Hutcheon E, McLennan JD, Urichuk L. Change in mental health status of young children participating in a respite service. J Can Acad Child Adolesc Psychiatry. 2011;20(2):(120-6). 103. Jayanthan A, Bernoux D, Bose P, Riabowol K, Narendran A. Multi-tyrosine kinase inhibitors in preclinical studies for pediatric CNS AT/RT: Evidence for synergy with Topoisomerase-I inhibition. Cancer Cell Int; 9;11(1):44-55. 2011 104. Jayanthan A, Incoronato A, Blackmore C, Bernoux D, Lewis VA, Stam R, Whitlock JA, Narendran A. Cytotoxicity, Combinability and Biological Correlates of ABT-737 Against Leukemia Cells with MLL Rearrangement. Pediatr Blood Cancer; 56(3):353-60. 2011 105. Jobling R, Ferrier RA, McLeod R, Petrin AL, Murray JC, Thomas MA. Monozygotic twins with variable expression of Van der Woude syndrome. Am J Med Genet A, 2011 Aug;155A(8):2008-10. Doi:10.1002/ ajmg,a,34022. Epub 2011 Jul 7. 106. Joffe AR, Quinonez LG, Robertson CMT, Dinu Irina A, Alton G, Coe J, Sauve R, Acton B, Ross DB, Rebeyka Ivan M and the Western Canadian Complex Pediatric Therapies Follow-up group. Outcomes after heart transplantation in children under Six years of age. The

Annals of Thoracic Surgery. Jul 2011; 92(1):174-182. 107. Johnson J, Tough SC. Delayed childbearing. Journal of Obstetrics and Gynaecology Canada, 2012; 34(1): 80–93. 108. Johnson K, Stang AS., Johnson D, Rowe BH, Hartling L. Different systemic corticosteroid regimens for the emergency management of acute asthma. Cochrane Database of Systematic Reviews 2012, Issue 1. 109. Johnstone J, Tyrrell GT, Marrie TJ, Garg S, Kellner JD, Streptococcus pneumoniae Alberta Team (SPAT). Streptococcus pneumoniae Meningitis in Alberta Pre- and Postintroduction of the 7-Valent Pneumococcal Conjugate Vaccine. Canadian Journal of Infectious Diseases and Medical Microbiology. 2011;4(Winter):137-41. 110. Joseph KS, Kramer M, Sauve R, Liu S, Rouleau J, Lisonkova S, Hutcheon J, Allen Alexander. International comparisons of perinatal and infant mortality: Influence of definition-based versus pragmatic birth registration on international comparisons of perinatal and infant mortality: population based retrospective study. Brit Med J. Feb 2012; 26(2): (124-30) 111. Kang J, Hagel BE, Emery CA, Meeuwisse W, Senger T. Assessing the representativeness of Canadian Hospitals Injury Reporting and Prevention Program (CHIRPP) sport and recreational injury data in Calgary, Canada. International Journal of Injury Prevention and Safey Promotion 2012;0(0):1-8.E-pub ahead of print. 112. Kanungo J, James A, McMillan D, Lodha A, Faucher D, Lee SK, Shah PS. Advanced maternal age and the

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outcomes of preterm neonates : a social paradox? Obstet Gynecol 2011 Oct;118(4):872–7. 113. K aplan B.J., Giesbrecht G.F., Leung B.M.Y., Field C.J., Dewey D., Bell R.C., Manca D.P., O’Beirne M., Johnston D.W., Pop V.J., Singhal N., Gagnon L., Bernier F.P., Eliasziw M., McCargar L.J., Kooistra L., Farmer A., Cantell M., Goonewardene L., Casey L.M., Letourneau N., Martin J.W. (in press). The Alberta Pregnancy Outcomes and Nutrition (APrON) cohort study: Rationale and methods. Maternal and Child Nutrition. 2012 doi: 10.1111/j.17408709.2012.00433.x. [Epub ahead of print] 114. Kaplan BJ, Leung B. Micronutrient treatment of mental disorders. Integrative Medicine: A Clinician’s Journal 2011; 10:32-39. 115. Karkhaneh M, Hagel BE, Couperthwaite A, Saunders D, Voaklnder DC, Rowe BH. Emergency department coding of bicycle and pedestrian injuries during the transition from ICD-9 to ICD-10. Injury Prevention 2012;(2):88-93. 116. Katz, S.L., McKim, D., Hoey, L., Barrowman, N., Kherani, T., Kovesi, T., Maclusky, I., Mah, J.K. Respiratory management strategies for Duchenne muscular dystrophy: practice variation amongst Canadian sub-specialists. Pediatr Pulmonol. 2012 Mar 26. [Epub ahead of print]. 117. Khan A, Thomas Hangartner, Neal J. Weinreb, John S. Taylor, Pramod K. Mistry. Risk factors for fractures and avascular osteonecrosis in type 1 Gaucher disease – a study from the International Collaborative Gaucher Group (ICGG) Gaucher Registry. 12 June 2012. JBMR Online 10.1002/ jbmr.1680

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118. K han, A., Trevenen, C.L., Wei, X.-C., Sarnat, H.B., Payne, E., Kirton, A. Alpers syndrome: The natural history of a case highlighting neuroimaging, neuropathology and fat metabolism. Journal of Child Neurology 2012;27: 636-640. 119. Kim, do Y., Hao, J., Liu, R., Turner, G., Shi, F.D., Rho, J.M. Inflammationmediated memory dysfunction and effects of a ketogenic diet in a murine model of multiple sclerosis. PLoS One. 2012;7(5):e35476. 120. Kingston D, Tough S, Whitfield H. Prenatal and Postpartum Maternal Psychological Distress and Infant Development: A Systematic Review. Child Psychiatry and Human Development, 2012, Oct;43(5):683-714 121. Kinlin L, Freedman SB. Evaluation of a Clinical Dehydration Scale in Children Requiring Intravenous Rehydration. Pediatrics. 2012; 129(5):e1211-9. 122. K irton, A. and deVeber, G. Cerebrovascular disease. In Pediatric Neurology: Principles and Practice. 5th Edition, Swaiman K, Ashwal S, Ferriero D eds. Mosby Elsevier, Philadelphia, 2012, pp1395-1436. 123. K irton, A. Focal ischemic stroke as a mechanism of cerebral injury in the perinatal period. In Neonatal Encephalopathy and Cerebral Palsy: Defining the Pathogenesis and Pathophysiology. American College of Obstetricians & Gynecologists, American Academy of Pediatrics. In press 2012. 124. K irton, A., Chang, T., Armstrong-Wells, J., Hernandez, M., Carpenter, J., Rifkin, M., Yager, J., Lynch, J., Ferriero, D., and the Members of the IPSS. Symptomatic neonatal arterial ischemic stroke: The

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International Pediatric Stroke Study. Pediatrics 2011,128(6):e1402-e1410. 125. Kooistra L, Crawford S, Gibbard B, Kaplan BJ, Fan J. Comparing attentional networks in fetal alcohol spectrum disorder and the inattentive and combined subtypes of attention deficit hyperactivity disorder. Dev Neuropsychol. 2011;36(5):566-77. 126. Kowalewski K, McLennan JD, McGrath PJ. A preliminary investigation of wait times for child and adolescent mental health services in Canada. J Can Acad Child Adolesc Psychiatry. 2011;20(2): (112-9). 127. Lafay-Cousin L, Bouffet E. In response to "Clinical features and management of carboplatin-related hypersensitivity reactions in pediatric low grade glioma”. Support Care Cancer. 2012; 20(4): 875-6 128. L afay-Cousin L, Hawkins C, Carret AS, Johnston D, Zelcer S, Wilson B, Jabado N, Scheinemann K, Eisenstat D, Fryer C, Fleming A, Mpofu C, Larouche V, Strother D, Bouffet E, Huang A. Central nervous system atypical teratoid rhabdoid tumors: the Canadian Pediatric Brain Tumor Consortium experience. Eur J Cancer. 2012; 48(3): 353-9 129. L afay-Cousin L, Hawkins C, Carret AS, Johnston D, Zelcer S, Wilson B, Jabado N, Scheinemann K, Eisenstat D, Fryer C, Fleming A, Mpofu C, Larouche V, Strother D, Bouffet E, Huang A. Central nervous system atypical teratoid rhabdoid tumours: The Canadian Paediatric Brain Tumour Consortium experience. Eur J Cancer 2012 Feb;48(3):353-9. 130. Lang E, Johnson D. How Does “Knowledge Translation” Affect my

Clinical Practice? Can J Emerg Med 2012;14:182-6 131. Langley JM, Scheifele d, Quach C, Vanderkooi O, Ward B, McNeil S, Dobson S, Kellner J, Kuhn S , Kollman T, MacKinnon-Cameron D, Smith B, Halperin SA. Safety and immunogenicity of 2010-2011 H1N12009-containing trivalent inactivated influenza vaccine in children 12 to 59 months of age previously given AS03-adjuvanted H1N12009 pandemic vaccine: a PHAC/CIHR Influenza Research Network (PCIRN) study. Vaccine 2012:30(23):3389-94 132. Langley JM, Vanderkooi OG, Garfield HA, Hebert J, Chandrasekaran V, Jain VK, Fries L. Immunogenicity and Safety of Two Dose Levels of a Thimerosal-Free Trivalent Seasonal Influenza Vaccine in Children 6-35 Months of Age: A Randomized, Controlled Trial. Journal of the Pediatric Infectious Diseases Society 2012;1(1):55-63. 133. Larouche A, Gaetan G, El-Bilali N, Quesnel-Valliere N. Martin SR, Alverez F, Shoukry NH, Soundeyns H. A case of Seronegative HCV infection in a child infected via mother-to-child transmission. J Clin Microbiol. 2012 Jul: 134. Larson, B., Herx, L., Williamson, T., Crowshoe L. Moving beyond the barriers: understanding how family medicine residents feel about providing aboriginal health care. Medical Education 2011; 45: 400-406. 135. Lazarevic D, Pistorio A, Palmisani E, Miettunen P, Ravelli A, Pilkington C, Wulffraat NM, Malattia C, Garay SM, Hofer M, Quartier P, Dolezalova P, Penades IC, Ferriani VP, Ganser G, Kasapcopur O, Melo-Gomes JA, Reed AM, Wierzbowska M, Rider LG, Martini A, Ruperto N; for the Paediatric

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Rheumatology International Trials Organisation(PRINTO). The PRINTO criteria for clinically inactive disease in juvenile dermatomyositis.Ann Rheum Dis. 2012 Jun 26. [Epub ahead of print] 136. Leal J, Vanderkooi OG, Church DL, MacDonald J, Tyrrell GJ, Kellner JD. Eradication of Invasive Pneumococcal Disease (IPD) Due to the 7-Valent Pneumococcal Conjugate Vaccine (PCV7) in Calgary, Canada. Pediatric Infectious Disease Journal 2012;31(9):e169-75. Epub 2012 June 5. 137. Lee C, Fotovati A, Triscott J, Chen J, Venugopal C, Singhal A, Dunham C, Kerr JM, Verreault M, Yip S, Wakimoto H, Jones C, Jayanthan A, Narendran A, Singh SK, Dunn SE. Polo-Like Kinase 1 (PLK1) Inhibition Kills Glioblastoma Multiforme Brain Tumour Cells in Part Through Loss of SOX2 and Delays Tumor Progression in Mice. Stem Cells; 30(6):1064-75. 2012 138. Lee SK, Singhal N, Aziz K, Cronin CM. The EPIQ evidence reviews - Practical tools for an integrated approach to knowledge translation. Paediatr Child Health. 2011 Dec;16(10):629-30 139. L emieux L. The bleeder. Medical Humanities .British Medical Journal. 2011; 37(2): 78. 140. L eung AK, Davies HD. Molluscum contagiosum. Current Pediatric Reviews 2012;8:346-349. 141. Leung AK, Sauve RS, Marchand V. The ‘picky eater’: the toddler or preschooler who does not eat. Paediatrics and Child Health 2012;17:455-457. 142. Li, D., Hodge, J., Wei, X., Kirton, A. Reduced ipsilesional cortical volumes in fetal periventricular venous infarction. Stroke 2012, 43(5):1404-7.

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143. Li K, Mary Ann Thomas, Richard M. Haber Ulerythema ophryogenes: a rarely reported cutaneous manifestation of Noonan syndrome. Case report and review of the literature. Journal of Cutaneous Medicine and Surgery (In press, 2011) 144. Liu J, Bernier F, Lauzon J, Lowry B, Chernos J. Application of microarray-based comparative genomic hybridization in prenatal and postnatal setting: three case reports. Genetics Research International. 2011 vol. 2011, Article ID 976398, 9 pages. 145. Liu J, Bernier F, Lauzon J, Lowry RB, Chernos J. Microarray-based comparative genomic hybridization and its utility in prenatal and postnatal settings. Genet Res Int. 2011; 2011:976398 Epub 2011 Aug 7. 146. Liu S, Joseph KS, Liston RM, Bartholemew S, Walker M, Leon JA, Kirby, R, Sauve R, Kramer M for the Maternal Health Study Group of the Canadian Perinatal Surveillance system (PHAC). Eclampsia in Canada: A population based study, 2003-2009. Obstetrics & Gynecology; Aug 2011; 118: 987-994. 147. Lockyer J., Wycliffe-Jones K., Raman M., Sandhu A., Fidler H. Moving into medical practice in a new community: the transition experience. J Contin Educ Health Prof. 2011 Summer; 31(3): 151-6. 148. Loucks C, Parboosingh JS, Chong J, Ober C, Siu VM, Hegele RA, Rupar CA, McLeod DR, Pinto A, Chudley AE, Innes AM. 2011. Identification of a common molecular basis underlying restrictive dermopathy in Old Colony Mennonite and Hutterite patients in North America. Am J Med Genet A. 2012 May;158A(5)1229-32

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149. Ma I, Brindl M, Ronksley P, Lorenzetti D, Sauve R, Ghali W. Use of simulationbased education to improve outcome of Central Venous Catheterization: A Systematic Review. Academic Medicine. Sept 2011; 86(9) 1137-1147. 150. Maddigan A, Truitt L, Arsenault R, Freywald T, Allonby O, Dean J, Narendran A, Xiang J, Weng A, Napper S, Freywald A. EphB Receptors Trigger Akt Activation and Suppress Fas Receptor-Induced Apoptosis in Malignant T Lymphocytes. J Immunol; 1;187(11):5983-94. 2011. 151. Mah, J.K. Congenital Myotonic Dystrophy. In: Gilman S, editor. MedLink Neurology. San Diego: MedLink Corporation. May 6, 2012 (access via www.medlink.com). 152. M ah, J.K., Anziska, Y., Buccella, F., Kinnett, K., McAdam, L., Rutter, M., Wagner, K. Short Stature (Height) in Duchenne Muscular Dystrophy (DMD): Parents and Boys/teens version. Parent Project Muscular Dystrophy April 2012 [access via: www.parentprojectmd. org]. 153. M ah, J.K., Biggar, D. Psychosocial Support Needs of Families of Boys with Duchenne Muscular Dystrophy [book chapter] for Neuromuscular Diseases, editor: Dr. Ashraf Zaher, In-Tech Open Access Publisher May 2012, ISBN: 979953-307-168-7. 154. Marciniuk DD, Hernandez P, Balter M, Bourbeau J, Chapman KR, Ford GT, Lauzon JL, Maltais F, O'Donnell DE, Goodridge D, Strange C, Cave AJ, Curren K, Muthuri S. Alpha-1 antitrypsin deficiency targeted testing and augmentation therapy: a Canadian Thoracic Society clinical practice guideline. Can Respir J. 2012 MarApr;19(2):109-16.

155. Marrie TJ, Tyrrell GJ, Garg S, Vanderkooi OG. Factors Predicting Mortality in Invasive Pneumococcal Disease in Adults in Alberta. Medicine (Baltimore) 2011:90(3):171-179. 156. Martinez-Soto T, Pacaud D, Stephure D, Trussell R, Huang C. Treatment of symptomatic osteoporosis in children: a comparison of two pamidronate dosage regimens. Journal of Pediatric Endocrinology and Metabolism 2011; 24(5-6): 271-4. 157. Masino, S.A., Rho, J.M. Mechanisms of Ketogenic Diet Action. In: Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, editors. Jasper's Basic Mechanisms of the Epilepsies [Internet]. 4th edition. Bethesda (MD): National Center for Biotechnology Information (US); 2012. 158. Matlow A, Forgie S, Pelude L, Embree J, Gravel D, Langley J, Le Saux N, Moore D, Mounchili A, Mulvey M, Shurgold J, Simor A, Thomas E, Vayalumkal JV, and the Canadian Nosocomial Infection Surveillance Program. National Surveillance of Methicillin-Resistant Staphylococcus aureus among Hospitalized Pediatric Patients in Canadian Acute Care Facilities, 19952007. Pediatric Infectious Diseases Journal 2012;31:814-820. 159. McCarthy A, Varghese S, Duggan A, Campbell G, Pottie K, Kuhn S. Evidence-based clinical guidelines for immigrants and refugees. Appendix 9: Malaria: Evidence Review for Newly Arriving Immigrants and Refugees. CMAJ 2011;183(12): e824-925 160. McDonald SW, Wall J, Forbes K, Kingston D, Kehler H,Vekved M, Tough S. Development of a prenatal psychosocial screening tool for postpartum depression and anxiety.

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Paediatric and Perinatal Epidemiology 2012; 26: 316-327. 161. McDonald, C.M., Han, J.J., Mah, J.K., Carter, G.T. Corticosteroids and Duchenne muscular dystrophy: Does earlier treatment really matter? Muscle Nerve 2012 Jun;45(6):777-9. 162. McGowan JE, Fenton TR, Wade AW, Branton JL, Robertson M. An exploratory study of sodium, potassium, and fluid nutrition status of tube-fed nonambulatory children with severe cerebral palsy. Appl Physiol Nutr Metab. 2012 Aug;37(4):715-23. doi: 10.1139/h2012050. Epub 2012 Jun 5. 163. McIntyre RE, Hardcastle C, Eng RL, Nettel-Aguirre A, Urmson K, Lardner DR, Livingstone M, Ewen A, Cox RG. Effect of dexamethasone on postoperative morbidity after dental rehabilitation in children. Can J Anaesth 2012; 59(1):34-40. 164. McNeil DA, Siever J, Tough S, Yee W, Rose MS, Lacaze-Masmonteil T. Hospital re-admission of late preterm or term infants is not a factor influencing duration of predominant breastfeeding. Arch Dis Child Fetal Neonatal Ed. 2012 Jun 29. 165. McNeil DA, Vekved M, Dolan SM, Siever J, Horn S, Tough SC. Getting more than they realized they needed: a qualitative study of women’s experience of group prenatal care. BMC Pregnancy and Childbirth 2012; 12:17. 166. Metcalfe A, Lall P, Ghali W, Sauve R. The association between Neighborhoods and Adverse Birth Outcomes: A Systematic Review and Meta-Analysis of multi-level studies.J Ped Perinat Epid. Jul 2011;25:236-245.

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167. Midgley JP, El-Kares R, Mathieu F, Goodyer P. Natural history of adolescentonset cystinosis. Pediatr Nephrol. 2011 Aug;26(8):1335-7. doi: 10.1007/s00467011-1904-z. 168. Mina R, von Scheven E, Ardoin SP, Eberhard BA, Punaro M, Ilowite N, Hsu J, Klein-Gitelman M, Moorthy LN, Muscal E, Radhakrishna SM, Wagner-Weiner L, Adams M, Blier P, Buckley L, Chalom E, Chédeville G, Eichenfield A, Fish N, Henrickson M, Hersh AO, Hollister R, Jones O, Jung L, Levy D, Lopez-Benitez J, McCurdy D, Miettunen PM, Quinterodel Rio AI, Rothman D, Rullo O, Ruth N, Schanberg LE, Silverman E, Singer NG, Soep J, Syed R, Vogler LB, Yalcindag A, Yildirim-Toruner C, Wallace CA, Brunner HI; Carra SLE Subcommittee. Consensus treatment plans for induction therapy of newly diagnosed proliferative lupus nephritis in juvenile systemic lupus erythematosus. Arthritis Care Res (Hoboken). 2012; 64:375-83. 169. Moules NJ, McCaffrey G, Laing C, Tapp D, Strother D. The experiences of grandparents of childhood cancer, Part 2: The need for support. J Pediatr Oncol Nurs. 2012 May;29(3):133-40. 170. Moules, NJ, McCaffrey G, Laing C, Tapp D, Strother D. Grandparents' experiences of childhood cancer, Part 1: Doubled and silenced. J Pediatr Oncol Nurs. 2012 May;29(3):119-32. 171. Mummery A, Narendran A, Lee KY. Targeting Epigenetics through Histone Deacetylase Inhibitors in Acute Lymphoblastic Leukemia. Curr Cancer Drug Targets; 11(7):882-93. 2011 172. Mutchinick OM, Luna-Muñoz L, Amar E, Bakker MK, Clementi M, Cocchi G, Da Graca Dutra M, Feldkamp ML, Landau D, Leoncini E, Li Z, Lowry RB, Marengo

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LK, Martínez-Frías ML, Mastroiacovo P, Metneki J, Morgan M, Pierini A, Rissman A, Ritvanen A, Scarano G, Siffel C, Szabova E, Arteaga-Vazquez J. Conjoined Twins: Phocomelia: a worldwide collaborative epidemiologic study of the International Clearinghouse for Birth Defects Surveillance and Research. Am J Med Genet C Semin Med Genet. 2011 157:274-287. doi: 10.1002/ajmg.c.30321. 173. Myers KA, Jeffery RM, Lodha A. Late–onset Leclercia adecarboxylata bacteraemia in a premature infant in the NICU. Acta Paeditr. 2012;101(1): e37–9. 174. Myers, K., Kirton, A., Esser, M., Payne, E., Howard, J. Thoracic myelopathy secondary to seizure following scoliosis surgery. J Child Neurol 2011, epub Dec 2. 175. Nair V, Soraisham AS, Akierman A. Neonatal withdrawal syndrome due to maternal codeine use. Paediatr Child Health 2012 May; 17(5):e40-41. 176. Navia D, McLennan J. Participation in a child growth monitoring program in a low-income community in the Dominican Republic. European Journal of Tropical Medicine and International Health. 2011;vol. 16, Supplement #2.3010 p 308. 177. O'Mahony, J., Bar-Or, A., Arnold, D.L., Sadovnick, .A.D, Marrie, R.A., Banwell, B. Canadian Pediatric Demyelinating Disease Network [Mah JK]. Masquerades of Acquired Demyelination in Children: Experiences of a National Demyelinating Disease Program. J Child Neurol. 2012 May 9. [Epub ahead of print].

178. Orioli IM, Amar E, Arteaga-Vazquez J, Bakker MK, Bianca S, Botto LD, Clementi M, Correa A, Csaky-Szunyogh M, Leoncini E, Li Z, López-Camelo JS, Lowry RB, Marengo L, MartínezFrías ML, Mastroiacovo P, Morgan M, Pierini A, Ritvanen A, Scarano G, Szabova E, Castilla EE. Sirenomelia: an epidemiologic study in a large dataset from the International Clearinghouse of Birth Defects Surveillance and Research, and literature review. Am J Med Genet C Semin Med Genet. 2011 157:358-373. doi: 10.1002/ajmg.c.30324. 179. Orioli IM, Amar E, Bakker MK, BermejoSánchez E, Bianchi F, Canfield MA, Clementi M, Correa A, Csáky-Szunyogh M, Feldkamp ML, Landau D, Leoncini E, Li Z, Lowry RB, Mastroiacovo P, Morgan M, Mutchinick OM, Rissmann A, Ritvanen A, Scarano G, Szabova E, Castilla EE. Cylopia: an epidemiologic study in a large dataset from the International Clearinghouse of Birth Defects Surveillance and Research. Am J Med Genet C Semin Med Genet. 2011 157:344-357. doi: 10.1002/ ajmg.c.30323. 180. Ortiz-Alvarez O, Mikrogianakis A, Cheng A et al. Management of the Pediatric Patient with an Acute Asthma Exacerbation. Pediatr Child Health. 2012. 17(5):251-256. 181. Ouellette-Kuntz, H., Coo, H., Yu, C.T., Lewis, S., Dewey, D., Hennessey, P. E., Jackman, Breitenbach, M.M., & Holden, J. A. (2012). National epidemiologic database for the study of autism in Canada (NEDSAC), Chronic Diseases and Injuries in Canada, 32(2), 90-100. 182. P acaud, D., Dewey, D. Neurocognitive outcome of children exposed to severe hypoglycaemia in utero.. Diabetes Management 2011; 1(1):129-140.

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183. Pendlebury JD, Yusuf K, Bano S, Lumb KJ, Schneider JM, Hasan SU. Prenatal cigarette smoke exposure and postnatal respiratory response to hypoxia and hypercapnia. Pediatr Pulmonol. 2012 May;47(5):487-97.

Annual Report 2012 | Department of Paediatrics

Alliance. Monitoring. Effectiveness and Safety of Antipsychotics in Children (CAMESA) guideline group. Evidence-based recommendations for monitoring safety of second generation antipsychotics in children and youth. Jointly published in: Journal of the Canadian Academy of Child and Adolescent Psychiatry August 2011; 20(3):218-233 and Paediatrics and Child Health November 2011; 16(9):581-589.

184. Perlman J, Kattwinkel J, Wyllie J, Guinsburg R, Velaphi S, Singhal N, CollaboratorsBoyle D, de Armeida MF, Davis P, Escobedo M, Goldsmith J, Halamek L, Lily H, McGowan JE, Mcmillan D, Niermeyer S, O'Donnell C, Rabi Y, Simon W, Stenson B, Szyld E, Tamura M, Wiener G, Wyckoff M. for the Neonatal ILCOR Task Force Group. Neonatal resuscitation: in pursuit of evidence gaps in knowledge. Resuscitation. 2012 May;83(5):545-50.

189. Qiu X, Lodha A, Shah PS, Sankaran K, Seshia MM, Yee W, Jefferies A, Lee SK; Canadian Neonatal Network. Neonatal outcomes of small for gestational age preterm infants in Canada. Am J Perinatol. 2012 Feb; 29(2):87-94.

185. P erry, R.J., Novikova, E., Wallace, A.M., Donaldson, M.D.C. Pitfalls in the diagnosis of 5a-Reductase type 2 deficiency during early infancy. Hormone Research Pediatrics 2011; 75:380-382

190. R abi Y, Singhal N, Nettel-Aguirre A. Room-air versus oxygen administration for resuscitation of preterm infants: the ROAR study. Pediatrics 2012;128(2):e374-81.

186. Picard D, Miller S, Hawkins C, Bouffet E, Rogers H, Chan T, Kim S, Ra Y, Fangusaro J, Korshunov A, Toledano H, Nakamura H, Hayden J, Chan J, Lafay-Cousin L, Hu P, Fan X, Muraszko K, Pomeroy S, Lau C, Ng H, Jones C, Van Meter S, Clifford S, Eberhart C, Gajjar A, Pfister S, Grundy R, Huang A. Integrative genomic analyses identify LIN28 and OLIG2 as markers of survival and metastatic potential in childhood central nervous system primitive neuroectodermal brain tumours. Lancet oncology 2012 Aug 13(8):838-48. Epub 2012 Jun 11 5.

191. Rasmussen C, Tamana S, Baugh L, Andrew G, Tough S, Zwaigenbaum L. Neuropsychological impairments on the NEPSY-II among children with FASD. Child Neuropsychology, First published online, March 5, 2012. doi:10.1080/09297 049.2012.658768

187. Potok V, Fonseca K, Vayalumkal JV. Clinician’s Corner - Headache after a European Vacation. Paediatrics and Child Health. 2011;16(7):391-2. 188. P ringsheim, T., Panagiotopoulos, C., Davidson, J. and Ho, J. for the Canadian

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192. Rasmussen C, Becker M, McLennan J, Urichuk L, Andrew G. An evaluation of social skills in children with and without prenatal alcohol exposure. Child Care Health Dev. 2011;37(5): 711-718. 193. Regalado ES, Guo DC, Villamizar C, Avidan N, Gilchrist D, McGillivray B, Clarke L, Bernier F, Santos-Cortez RL, Leal SM, Bertoli-Avella AM, Shendure J, Rieder MJ, Nickerson DA; NHLBI GO Exome Sequencing Project, Milewicz DM. Exome sequencing identifies SMAD3 mutations as a cause of familial thoracic aortic aneurysm and

dissection with intracranial and other arterial aneurysms. Circ Res. 2011 Sep 2;109(6):680 194. Reis LM, Tyler RC, Volkmann Kloss BA, Schilter KF, Levin AV, Lowry RB, Zwijnenburg PJ, Stroh E, Broeckel U, Murray JC, Semina EV. PITX2 and FOXC1 spectrum of mutations in ocular syndromes. Eur J Hum Genet 2012 20:1224-1233. doi: 1038/ ejhg.2012.80. 195. R ho, J.M. Adenosine: a fundamental factor formed from Fatty feasts for fighting fits? Epilepsy Curr. 2012; 12(1):19-21. 196. Rivière JB, Mirzaa GM, O'Roak BJ, Beddaoui M, Alcantara D, Conway RL, St-Onge J, Schwartzentruber JA, Gripp KW, Nikkel SM, Worthylake T, Sullivan CT, Ward TR, Butler HE, Kramer NA, Albrecht B, Armour CM, Armstrong L, Caluseriu O, Cytrynbaum C, Drolet BA, Innes AM, Lauzon JL, Lin AE, Mancini GM, Meschino WS, Reggin JD, Saggar AK, Lerman-Sagie T, Uyanik G, Weksberg R, Zirn B, Beaulieu CL; Finding of Rare Disease Genes (FORGE) Canada Consortium, Majewski J, Bulman DE, O'Driscoll M, Shendure J, Graham JM Jr, Boycott KM, Dobyns WB. De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes. Nat Genet. 2012 Jun 24;44(8):934-40. doi: 10.1038/ ng.2331. PubMed PMID: 22729224; PubMed Central PMCID: PMC3408813. 197. Roberts E, Metcalfe A, Jack M, Tough S. Factors that influence the childbearing intentions of Canadian men. Human Reproduction. 2011;26(5):1202–1208. 198. Robertson CM, Alton GY, Bork KT, Joffe AR, Tawfik GC, Sauve RS, Moddemann DM, Ross DB, Rebeyka IM. Bilateral

sensory permanent hearing loss after palliative hypoplastic left heart syndrome operation. Ann Thorac Surg. 2012 Apr; 93(4):1248-53. 199. Rodd C, Lang B, Ramsay T, Alos N, Huber AM, Cabral DA, Scuccimarri R, Miettunen PM, Roth J, Atkinson SA, Couch R, Cummings EA, Dent PB, Ellsworth J, Hay J, Houghton K, Jurencak R, Larché M, LeBlanc C, Oen K, Saint-Cyr C, Stein R, Stephure D, Taback S, Lentle B, Matzinger M, Shenouda N, Moher D, Rauch F, Siminoski K, Ward LM, Canadian Steroid-Associated Osteoporosis in the Pediatric Population (STOPP) Consortium (including Lewis V): Incident vertebral fractures among children with rheumatic disorders 12 months after glucocorticoid initiation: a national observational study. Arthritis Care Res (Hoboken). 2012 Jan;64(1):122-31. 200. Ronksley PE, Tonelli M, Quan H, Manns BJ, James MT, Clement FM, Samuel S, Quinn RR, Ravani P, Brar SS, Hemmelgarn BR; Alberta Kidney Disease Network. Validating a case definition for chronic kidney disease using administrative data. Nephrol Dial Transplant. 2012 May;27(5):1826-31. doi: 10.1093/ndt/gfr598. Epub 2011 Oct 19. 201. Sam J, Pierse M, Al-Qahtani Q, Cheng A. Implementation and Evaluation of a Simulation Curriculum for Pediatric Residency Programs including Just in Time In-Situ Mock Codes. Pediatrics and Child Health. Pediatr Child Health. 2012, 17(1):1-5. 202. S amuel SM, Foster BJ, Tonelli MA, Nettel-Aguirre A, Soo A, Alexander RT, Crowshoe L, Hemmelgarn BR, Pediatric Renal Outcomes Canada Group. Dialysis and transplantation among Aboriginal children with kidney failure. CMAJ 2011;183(10):E665-72.

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203. S amuel SM, Nettel-Aguirre A, Hemmelgarn BR, Tonelli MA, Soo A, Clark C, Alexander RT, Foster BJ. Graft failure and adaptation period to adult health care centers in pediatric renal transplant patients. Transplantation 2011;91(12):1380-5. 204. S arnat, H.B. Ontogenesis of striated muscle. In: Polin RA, Fox WW, Abman SH, editors. Fetal and Neonatal Physiology. 4th edition. Philadelphia: Elsevier. 2011. Vol. 2; pp 1924-1947. 205. S arnat, H.B., Flores-Sarnat, L. Developmental disorders of the nervous system. In: Bradley’s Neurology in Clinical Practice, 2nd ed., Daroff RB, Fenichel G, Jankovic J, Mazziotta J, editors. Oxford UK, NY: Oxford University Press. 2012; Chapter 64. 206. S arnat HB, Flores-Sarnat, L, Casey R, Scott P, Khan A. Endothelial ultrastructural alterations of intramuscular capillaries in infantile mitochondrial cytopathies: “Mitochondrial angiopathy”. Neuropathology. Online: 12 Mar 2012 | DOI: 10.1111/j.1440-1789.2012.01308.x. 207. S arnat, H.B., Flores-Sarnat, L., Hader, W., Bello-Espinosa, L. Mitochondrial “hypermetabolic” neurons in paediatric epileptic foci. Canadian Journal of Neurological Sciences 2011:38:909-917. 208. S arnat, H.B., Flores-Sarnat, L., Pinter, J.D. Chapter 4. Neuroembryology. In: Youman’s Neurological Surgery, 6th ed., Winn HR, editor. Philadelphia: SaundersElsevier. 2012; pp 78-97. Supplementary references e10-e14. 209. S arnat, H.B., Wei, X.-C., FloresSarnat, L., Trevenen, C.L., Barlow, K. Fetal opercular cavernous angioma causing cerebral cleft; contralateral primitive vascular anomaly and subicular

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dysplasia. Journal of Child Neurology 2012;27:478-484. 210. Schechter, T., Kirton, A., Laughlin, S., Pontigon, A., Finkelstein, Y., MacGregor, D., Chan, A., deVeber, G., Brandao, L. Safety of anticoagulants in children with arterial ischemic stroke. Blood 2012; 119(4):949-56. 211. Scheifele DW, Ward BJ, Dionne M, Vanderkooi O, Langley JM, Dobson S, Li Y, Law B, Halperin SA, for the Public Health Agency of Canada/Canadian Institutes of Health Research Influenza Research Network (PCIRN) Rapid Trials Investigators (Kellner JD, member). Evaluation of Adjuvanted Pandemic H1N12009 Influenza Vaccine After One and Two Doses in Young Children. Pediatric Infectious Disease Journal 2011;30(5):402-7. 212. S chmeling H, Stephens S, Goia C, Manlhiot C, Schneider R, Luthra S, Stringer E, Feldman BM. Nailfold capillary density is importantly associated over time with muscle and skin diseases activity in juvenile dermatomyositis. Rheumatology 2011, 50: 885-893 213. Schmidt B et al for the CAP Investigators (including D Dewey and Sauve RS ). Survival without disabilities to 5 years after neonatal caffeine treatment for apnea of prematurity. JAMA. 2012 Jan 18;307(3):275-82. 214. Schuh S, Zemek R, Plint A, Black K, Freedman S, Porter R, Gouin S, Hernandez A, Johnson D. Magnesium Use in Asthma Pharmacotherapy: A Pediatric Emergency Research Canada Study. Pediatrics 2012; 129(5):852-9. 215. Scott SD, Grimshaw J, Klassen TP, Nettel-Aguirre A, Johnson DW. Understanding implementation

processes of clinical pathways and clinical practice guidelines in pediatric contexts: a study protocol. Implement Sci. 2011;(6):133. 216. Shah V, Chirinian N, Lee S, Singhal N, Dow K, James A, Mohamed I, RouvinezBouali N, Sankaran K, Yee W. Does the use of glycerin laxatives decrease feeding intolerance in preterm infants? Paediatrics and Child Health 2011 November; 16(9): e68-e70. 217. Shaikh K, Premji SS, Rose MS, Kazi A, Khowaja S, Tough S. The association between parity, infant gender, higher level of paternal education and preterm birth in Pakistan: a cohort study. BMC Pregnancy and Childbirth 2011;11:88. 218. Shen, X.M., Crawford, T.O., Brengman, J., Acsadi, G., Iannaconne, S., Karaca, E., Khoury, C., Mah, J.K., Edvardson, S., Bajzer, Z., Rodgers, D., Engel, A.G. Functional consequences and structural interpretation of mutations of human choline acetyltransferase. Hum Mutat. 2011 Nov;32(11):1259-67. 219. Shi M, Wang A, Prescott D, Waterhouse C, Zhang S, McDougall JJ, Sharkey KA, McKay DM. Infection with an Intestinal Helminth Parasite Reduces Freund’s complete adjuvant-induced monoarthritis in mice. Arthritis Rheum. 2011; 63(2):434-44 220. Siffel C, Correa A, Amar E, Bakker MK, Bermejo-Sánchez E, Bianca S, Castilla EE, Clementi M, Cocchi G, Csáky-Szunyogh M, Feldkamp ML, Landau D, Leoncini E, Li Z, Lowry RB, Marengo LK, Mastroiacovo P, Morgan M, Mutchinick OM, Pierini A, Rissmann A, Ritvanen A, Scarano G, Szabova E, Olney RS. Bladder exstrophy: an epidemiologic study from the International Clearinghouse for Birth Defects Surveillance and Research,

and an overview of the literature. Am J Med Genet C Semin Med Genet. 2011 157:321-332. doi: 10.1002/ajmg.c.30316. 221. Sigalet E, Donnon T, Grant V. Undergraduate students' perceptions of and attitudes toward a simulation-based interprofessional curriculum: The KidSIM ATTITUDES questionnaire. Simul Healthc 2012 Aug 16 [Epub ahead of print]. 222. Siminoski K, Lee KC, Jen H, Warshawski R, Matzinger MA, Shenouda N, Charron M, Coblentz C, Dubois J, Kloiber R, Nadel H, O'Brien K, Reed M, Sparrow K, Webber C, Lentle B, Ward LM; STOPP Consortium (D.Stephure is a member). Anatomical distribution of vertebral fractures: comparison of pediatric and adult spines. Osteoporos Int. 2012; 23:1999-2008. Epub 2011 Nov 23. 223. Siminoski, K., Lee, K-C., Jen, H., Warshawski, R., Matzinger, M.A., Shenouda, N., Charron, M., Coblentz, C., Dubois, J., Kloiber, R., Nadel, H., O’Brien, K., Reed, M., Sparrow, K., Webber, C., Lentle, B., Ward, L.M. and the Canadian STOPP Consortium (D. Stephure is a member). Anatomical distribution of vertebral fractures: comparison of pediatric and adult spines. Osteoporosis Int 2011 November. 224. Siminoski, K., Lee, K.-C., Abish, S., Alos, N., Bell, T., Blydt-Hansen, T., Couch, R., Cummings, E.A., Ellsworth, J., Feber, J., Fernandez, C.V., Halton, J., Huber, A.M., Israels, S., Jurencak, R., Lang, B., Laverdière, C., LeBlanc, C., Lewis, V., Midgley, J., Miettunen, P.M., Oen, K., Phan, V., Pinsk, M., Rauch, F., Rodd, C., Roth, J., Saint-Cyr, C., Scuccimarri, R., Stephure, D., Taback, S., Wilson, B., Ward, L.M. and the Canadian STOPP Consortium (D. Stephure is a member). The development of bone mineral lateralization in the arms. Osteoporosis International 2012 June.

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225. Singh A, Jayanthan A, Farran A, Elwi AN, Kim SW, Farran P, Narendran A. Induction of apoptosis in pediatric acute lymphoblastic leukemia (ALL) cells by the therapeutic opioid methadone and effective synergy with Bcl-2 inhibition. Leuk Res.; 35(12):1649-57. 2011 226. S inghal N, Lockyer J, Fidler H, Aziz K, McMillan D, Qiu X, Ma X, Du L, Lee SK. Acute Care of At-Risk Newborns (ACoRN): quantitative and qualitative educational evaluation of the program in a region of China. BMC Med Education 2012 June; 12(44):1-8. 227. S inghal N, Lockyer J, Fidler H, Keenan W, Little G, Bucher S, Qadir M, Niermeyer S. Helping Babies Breathe: Global neonatal resuscitation program development and formative educational evaluation. Resuscitation. 2012 Jan;83(1):90-6. 228. Sivanandan S, Rabi Y, Kamaluddeen M, Akierman A, Lodha A. Subcutaneous fat necrosis as a complication of therapeutic hypothermia in a term neonate. Indian J Pediatr. 2012; 79(5):664–6. 229. Sivanandan S, Soraisham AS, Swarnam K. Choice and duration of antimicrobial therapy for neonatal sepsis and meningitis. Inter J Pediatr. 2011; 2011:712150. 230. Smyth D, Al Awad E, Akierman A, Remington T, Barber D, Vayalumkal J. Eosinophilic Pustular Folliculitis in a Premature Infant: Case Report and Literature Review. Journal of NeonatalPerinatal Medicine 2012(5):179-182. 231. Soon IS, Wrobel I, deBruyn JC, Sauve R, Sigalet DL, Kaplan BS, Proulx MC, Kaplan GG. Postoperative Complications Following Colectomy For Ulcerative Colitis In Children: A

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Population-Based Study. J Pediatr Gastroenterol Nutr. 2012 Jun;54(6):763-8. Epub 2011 Dec 12.

Results of Children’s Oncology Group study P9641. J Clin Oncol 2012 May 20;30(15):1842-8.

232. S oraisham AS, Kamaluddeen M, Trevenen C. Primary pulmonary lymphangiectasia in an infant with Trisomy 21. J Neonatal Perinatal Med 2011; 4:383-385.

239. Swarnam K, Soraisham AS, Sivanandan S. Advances in the management of meconium aspiration syndrome. Inter J Pediatr. 2012; 2012:359571.

233. S oraisham AS, Sauve R, Singhal N. Indomethacin tocolysis and neurodevelopmental outcome. Indian J Pediatr . 2011 Aug;78(8): 946–952.

240. Sword W, Heaman MI, Brooks S, Tough S, Janssen PA, Young D, Kingston D, Helewa ME, Akhtar-Danesh N, Hutton E. Women's and care providers' perspectives of quality prenatal care: A qualitative descriptive study. BMC Pregnancy and Childbirth, 2012, 12:29.

234. S oraisham AS, Trevenen C, Wood S, Singhal N, Sauve R. Histological chorioamnionitis and neurodevelopmental outcome in preterm infants. J Perinatol. 2012 May 3. doi: 10.1038/jp.2012.49. 235. Stafstrom, C.E., Rho, J.M. Neurophysiology of Seizures and Epilepsy. In: Pediatric Neurology: Principles and Practice, 5th Edition, Kenneth Swaiman, Stephen Ashwal, Donna Ferreiro (Eds.), Elsevier, 2011. 236. Stafstrom, C.E., Rho, J.M. The ketogenic diet as a treatment paradigm for diverse neurological disorders. Front Pharmacol. 2012;3:59. 237. S teele M and Narendran A. Mechanisms of Defective Erythropoiesis and Anemia in Pediatric Acute Lymphoblastic Leukemia (ALL). Ann Hematol;.[Epub ahead of print]. Apr 29, 2012 238. S trother D, London WB, Schmidt ML, Brodeur GM, Shimada H, Thorner P, Collins MH, Tagge E, Adkins S, Reynolds CP, Murray K, Lavey R, Matthay KK, Castleberry R, Maris JM, Cohn SL. Outcome after surgery alone or with restricted use of chemotherapy for patients with low-risk neuroblastoma:

241. Talavlikar R, Meatherill B, Desai S, Carson J, Kuhn S. Mycobacterium senegalense Soft Tissue Infection Related to Fish Tank Exposure. Can J Infect Dis Med Microbiol 2011;22(3):101-3 242. Tan, M., Shroff, M., deVeber, G., Moharir, M., Pontigon, A., Kirton, A. Sagittal sinus compression is associated with neonatal cerebral sinovenous thrombosis. Pediatrics 2011; 128(2): e429-35. 243. T ough SC, Vekved M, Newburn-Cook C. Do factors that influence pregnancy planning differ by maternal age? A population based survey. Journal of Obstetrics and Gynaecology Canada 2012;34(1):39-46. 244. Van der Knaap MS, Wassmer E, Wolf NI, Ferreira P, Topcu M, Wanders RJ, Waterham HR, Ferdinandusse S, MRI as diagnostic tool in early-onset peroxisomal disorders. Neurology 78(17):1304-8, 2012 245. V anderkooi OG, Church DL, MacDonald J, Zucol F, Kellner JD (2011) Community-Based Outbreaks in Vulnerable Populations of Invasive

Infections Caused by Streptococcus pneumoniae Serotypes 5 and 8 in Calgary, Canada. PLoS ONE 6(12): e28547. doi:10.1371/journal. pone.0028547. 246. V anderkooi OG, Gregson DB, Kellner JD, Laupland KB. Staphylococcus aureus Bloodstream Infections in Children: A Population Assessment. Paediatrics & Child Health 2011;16(5):276-80. 247. Vanderkooi OG, Scheifele DW, Girgenti D, Halperin SA, Patterson SD, Gruber WC, Emini EA, Scott DA and Kellner JD for the Canadian PCV13 Study Group. Safety and Immunogenicity of a 13 Valent Pneumococcal Conjugate Vaccine in Healthy Infants and Toddlers Given with Routine Pediatric Vaccinations in Canada. Pediatric Infectious Disease Journal 2012;31(1):72-7. 248. VanderPluym C, Tawfik G, Hervas-Malo M, Lacaze-Masmonteil T, Kellner JD, Robinson J. Empiric Therapy of Possible Neonatal Herpes Simplex Virus Infection. Journal of Maternal-Fetal and Neonatal Medicine 2012;25(8):1278-82. Epub 2011 Nov 10. 249. V ayalumkal JV, Suh KN, Toye B, Ramotar K, Saginur R, Roth VR. Skin and Soft Tissue Infections Caused by Methicillin-Resistant Staphylococcus aureus (MRSA): An Affliction of the Underclass. Canadian Journal of Emergency Medicine 2012;14(6):335-343 250. V eale, P, Woloschuk, W, Coderre, S, McLaughlin, K, Wright, B. Comparison of student performance on internally prepared clerkship examinations and NBME subject examinations. Canadian Medical Education Journal CMEJ 2011 2(2): e81-e85

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251. Veenhuyzen GD, Quinn FR, Wilton SB, Clegg R, Mitchell LB. Diagnostic pacing maneuvers for supraventricular tachycardias: part 2. Pacing Clin Electrophysiol. 2012 Jun;35(6):757-69. 252. Verhey, L. H., Branson, H. M., Shroff, M. M., Callen, D. J., Sled, J. G., Narayanan, S., Banwell, B. Canadian Pediatric Demyelinating Disease Network (Mah J, member). MRI parameters for prediction of multiple sclerosis diagnosis in children with acute CNS demyelination: a prospective national cohort study. Lancet Neurol, 10(12), 1065-73. 253. W ainer S, Parmar SM, Allegro D, Rabi Y, Lyon ME. Impact of a Transcutaneous Bilirubinometry Program on Resource Utilization and Severe Hyperbilirubinemia. Pediatrics 2012;129:77–86 254. Willemsen MH, Vulto-van Sifhout AT, Nilesen WM, Wissink-Lindhout MW, Yntema HG, Philip N, Berry-Kravis EM, Kini U, van Ravenswaaij CMA, Chiaie BD, Innes AM, Houge G, Kosonen T, Cremer K, Fannemel M, Stray-Pedersen A, Reardon W, Ignatius J, Lachlan K, Mircher C, Drunat S, Kleefstra T. 2011. Update on Kleefstra Syndrome. Mol Syndromol 2012 Apr:2(3-5):202-212. 255. Win AK, Walters RJ, Buchanan DD, Jenkins MA, Sweet K, Frankel WL, de la Chappelle A, McKeone DM, Walsh MD, Clendennig M, Pearson SA, Pavluk E, Nagler B, Hopper JL, Gattas MR, Goldblatt J, George J, Suthers GK, Phillips KD, Woodall S, Arnold J, Tucker K, Field M, Greening S, Gallinger S, Aronson M, Perrier R, Woods MO, Green JS, Walker N, Rosty C, Parry S, Young JP. Cancer risks for relatives of patients with serrated polyposis. Am J Gastroenterol. 2012. 107(5); 770-8

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256. Wong T, Johnson D, Ganshorn H, Maconochie IK, Hartling L, Stang AS. Combined and alternating parecetamol and ibuprofen for fever in children. Cochrane Database of Systematic Reviews 2012, Issue 2. 257. Y ee WH, Scotland J, Pham Y, Finch R, Lee SK, Singhal N, Dow K, James A, Mohamed I, Rouvinez-Bouali N, Sankaran K, Shah V. Does the use of primary continuous positive airway pressure reduce the need for intubation and mechanical ventilation in infants <=32 weeks' gestation? Paediatrics and Child Health 2011 December; 16(10): 633-637. 258. Y ee WH, Soraisham AS, Shah VS, Aziz K, Yoon W, Lee SK, Shah PS and Canadian Neonatal Network. Incidence and timing of presentation of necrotizing enterocolitis in preterm infants. Pediatrics 2012 February; 129(2):e298-e304. 259. Y usuf K, Kamaluddeen M, Hasan SU, Al-Awad E, Finch RA, Akierman AR. Ionized calcium levels in umbilical cord blood of women with preeclampsia and normotensive pregnancies. J Matern Fetal Neonatal Med. 2012 Feb;25(2):203-5 260. Y usuf K, Kamaluddeen M, Wilson RD, Akierman A. Carboxyhemoglobion levels in umbilical cord blood in preeclampsia and intrauterine growth retardation. J Perinat Med, 2012, June 24, 2012 doi: 10.1515/jpm-2011-0312 261. Zvaigzne CG, Patton DJ, Kaur H, Trevenen CL, Kaura D. Subscapular tumoral calcinosis in a toddler: case report. Journal of Radiology Case Reports, Vol 6, No 6 (2012).

Acknowledgements The Department of Paediatrics gratefully acknowledges and thanks the following persons and groups for their contributions to this report: Joslyn Fernandes – Annual Report Project Manager Sarah Merrill – Photographs, special features and awards Clare Hildebrant – Clincial data synthesis WILMA OLIVIER-WALDEN and team, IMAGINE Creative, University of Calgary Special thanks also to The Alberta Children’s Hospital Foundation, Department Administrative staff, Section Chiefs, Department members and Administrative Assistants for their contributions.