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A targeted therapy resurrected by the Moon Shots Program™ at The University of Texas MD Anderson Cancer Center has produced unprecedented response rates among patients with metastatic non-small cell lung cancer that carries a highly treatmentresistant mutation.

In a phase 2 clinical trial, the drug poziotinib has shrunk tumors by at least 30 percent in eight of 11 (73 percent) non-small cell lung cancer patients whose cancer includes an epidermal growth factor receptor (EGFR) mutation called an exon 20 insertion. Shrinkage ranged from 30 percent to 50 percent among the eight patients reaching partial response. One patient has progressed on the clinical trial, which began in March. All patients experienced some tumor shrinkage. “We’ve had no effective drugs for these patients, who historically have progression free survival of about two months, and a response rate of less than 20 percent for other therapies,� said clinical trial leader John Heymach, M.D., Ph.D., chair of Thoracic/Head and Neck Medical Oncology at MD Anderson and holder of the David Bruton Junior Chair in Cancer Research. “These early results are highly encouraging, and our research shows that poziotinib’s structure makes it a great potential fit for attacking this mutation,� Heymach said.

Preliminary results were presented at the International Association for the Study of Lung Cancer 18th World Conference on Lung Cancer in Yokohama, Japan, by Yasir Elamin, M.D., assistant professor of Thoracic/Head and Neck Medical Oncology.

The investigator-initiated clinical trial marks the latest progress in the identification and development of poziotinib for this group of patients conducted by MD Anderson’s Lung Cancer Moon Shot™, which is co-led by Heymach as part of the institution’s Moon Shots Program™. The program was launched in 2012 to accelerate the development of new approaches to cancer based on scientific discoveries.

About 2 percent of non-small cell lung cancer patients (about 3,500 annually in the United States) have an EGFR exon 20

Six of 11 patients have had their dose reduced due to side effects, mainly due to rash but also diarrhea, mucositis and paronychia – inflammation of the tissue around finger nails and toenails.

Poziotinib had been tried and abandoned as a general EGFR inhibitor against lung cancer when Heymach’s team turned up evidence of its potential against exon 20 through a drug screening program that’s part of the moon shot.

Spectrum Pharmaceuticals, a Nevada-based biotechnology company that initially developed poziotinib. Subsequent collaboration included compassionate use of poziotinib for some patients with advanced disease and rapid development of the phase 2 clinical trial.

The Lung Moon Shot has funded the effort from the beginning, from preclinical identification and confirmation through the Postdoctoral fellow Jacqulyne Robichaux, clinical trial.

Ph.D., tapped the Genomic Marker-Guided A scientific paper describing the group’s Therapy Initiative (GEMINI), which includes tumor samples and detailed clinical preclinical research is pending with a major information on more than 4,000 lung cancer journal. Spectrum has provided poziotinib patients treated at MD Anderson since 2012. and also partially funds the trial.

Robichaux developed EGFR exon 20 NSCLC cell lines as well as patient-derived xenograft models, and tested a variety of EGFR inhibitors against them under the Lung Moon Shot’s drug repurposing program. “Poziotinib is the only drug we’ve ever found that was dramatically better for exon 20 than it was for the classical EGFR mutation, T790M, that everyone tests,� Heymach said.

Working with Shuxing Zhang, PHARMD, Ph.D., associate professor of Experimental Therapeutics, the multidisciplinary team identified structural aspects of the drug that explain that divergent impact.

Heymach and colleagues then contacted

Based on the MD Anderson team’s discoveries, the institution is developing intellectual property related to the use of poziotinib for the treatment of these mutant cancers.

Co-authors with Heymach, Elamin, Robichaux and Zhang are Vincent Lam, M.D., Anne Tsao, M.D., Charles Lu, M.D., George Blumenschein, M.D., Jonathan Kurie, M.D., and Monique Nilsson, Ph.D., of Thoracic/Head and Neck Medical Oncology; Zhi Tan of Experimental Therapeutics; Julie Brahmer, M.D., of the Bloomberg-Kimmel Institute for Cancer Immunotherapy at Johns Hopkins, Baltimore; Anna Truini, Ph.D., and Katerina Politi, Ph.D., Yale School of Medicine; Adriana Estrada-Bernal and Robert Doebele, M.D., Ph.D., University of Colorado School of Medicine; Shengwu Liu, Ph.D., Ting Chen, Ph.D., Shuai Li, M.D., and Kwok-Kin Wong, M.D., Ph.D., of Perlmutter Cancer Center at New York University Langone Medical School, and Zane Yang, M.D., of Spectrum Pharmaceuticals, Henderson, Nev. Zhi Tan also is a graduate student in the MD Anderson UTHealth Graduate School of Biomedical Science.

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Nine out of 10 Americans eat more sodium (salt) than they need. Too much sodium increases your risk for health problems like high blood pressure.

To eat less sodium, you don’t have to make lots of changes at once. If you cut back on sodium little by little, your taste for salt will change with time.

Use these tips to help lower the amount of sodium in your diet.

Know your sodium limit.

Ask your doctor how much sodium is okay for you. The general guidance is: • Healthy adults and teens age 14 and older need to limit their sodium intake to no more than 2,300 mg a day (about 1 teaspoon of salt). • Some adults, including people with high blood pressure, need to limit their sodium intake to 1,500 mg a day. • Children need no more than 1,500 to 2,200 mg a day of sodium, depending on how old they are.

• Use the Nutrition Facts label to check the amount of sodium in foods. Try to choose products with 5% Daily Value (DV) or less. A sodium content of 20% DV or more is high. • Look for foods labeled “low sodium,â€? “reduced sodium,â€? or “no salt added.â€?

beans, or fish), choose ones with labels that say “low sodium,â€? “reduced sodium,â€? or “no salt added.â€? • Compare the sodium in prepared foods like bread, soup, and frozen meals. Choose the ones with less sodium. • Limit processed meats – especially ones that are salted, smoked, or cured, like hot dogs, bacon, and deli meats.

If you use canned foods that aren’t low in sodium, rinse them before eating or cooking with them. This will wash away some of the salt. • Load up on vegetables, fruits, beans, and peas, which are naturally low in sodium. Fresh, • Use unsalted margarine or spreads with no trans fats. frozen, and dried options are all good choices. • When you buy canned foods (like vegetables, • Don’t add salt to the water when you cook

pasta or rice. • Try different herbs and spices to flavor your food, like ginger or garlic, instead of salt. • Take the salt shaker off your table.

• When you order at a restaurant, ask that salt not be added to your food. • Choose low-sodium options when you can – like dishes that are steamed, broiled, or grilled.

Replace high-sodium foods with highpotassium foods. Eating foods with potassium can help lower your blood pressure. Good sources of potassium include potatoes, cantaloupe, bananas, beans, milk, and yogurt.

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One of the greatest things about the holidays is the food. For many of us, Thanksgiving dinner is the best meal of the year. Unfortunately, Thanksgiving can also kick off a season of unhealthy overeating that can be particularly detrimental to those who have diabetes or are at risk of getting the illness.

consumption might affect your medications.

· Stay active. Instead of taking a nap after your Thanksgiving dinner, why not take a walk? Regular exercise may help you avoid or control diabetes.

to remember that during the holidays.

We have more information about diabetes and more advice to keep you healthy at www.phoebewellnesswatch.com.

The primary risk factors for diabetes include weight, inactivity and family history. That’s why exercise and healthy time to remember ways you can enjoy eating are so important, especially if holiday meals and parties without putting diabetes runs in your family. Remember your health at risk. Here are some tips: the phrase “fight the fad.” You do not need to try to latest fad diet or trendy exercise · Don’t pack your plate. Portion craze to be healthy. Moderate regular exercise such as walking, combined with a control is crucial. A second, small well-balanced and reasonable diet are the helping of green bean casserole may be best ways to reduce your chances of okay, but a third is overdoing it. getting diabetes. It’s especially important

November is Diabetes Awareness Month, so it’s a good

· Focus on the Thanksgiving turkey and veggies. Do your best to stay away from the carbohydrates and desserts altogether, or just have a small taste of mashed potatoes and pecan pie.

· Avoid sugary drinks. Sure, sodas and sweet tea are delicious, but they can be packed with sugar. Sugar-free drinks and water are much better for you.

· Limit your alcohol intake.

Alcohol can make maintaining a safe blood sugar level much more difficult. One or two drinks may be okay, but if you are on insulin or any medication, make sure you talk to your doctor about how alcohol

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Hidden Hunger: Do You Know Where Your Nutrients Are? When you cruise the drive-thru (50 million Americans eat at a fast-food restaurant every day), chances are you?re not eating highly nutritious, good-for-you food. The Double Bacon King Burger at Burger King weighs in with 1,150 calories and 2,150 mg of sodium, not to mention 79 g of fat (31 g is sat fat -- 50 percent more than you should get in a day, and in just one burger)!

But if you?re feasting on a tasty baby kale salad, 100 percent whole-wheat bread or a side of fresh peas, well, you?re expecting to get a big nutrient bang for each bite.

Less bang for your bite: Unfortunately, a combination of yield-increasing agricultural-biz changes in plants and the effects of increasing carbon dioxide and methane in the atmosphere (carbon-based fuels and massive livestock farms add to climate change) have altered plant nutrient levels. Even kale, whole wheat and tomatoes are delivering fewer vitamins and minerals per bite than they used to, while their carbs per bite have gone up.

How does this happen? As carbon dioxide is pumped up in the atmosphere (almost doubling in recent years, and expected to go much higher), it increases the sugar (carb) content of plants and decreases their levels of calcium, phosphorus, zinc and iron, as well as protein in wheat and rice -- and, depending on whose data you look at, the drop could be between 2 and 8 percent. This comes on the heels of a 2004 study in the Journal of the American College of Nutrition that found 43 garden crops with notable declines in nutrients such as protein, calcium, phosphorus, iron, vitamin C and riboflavin between 1950 and 1999.

That means even on a plant-lovin? diet, you can suffer from hidden hunger -and that undernutrition or malnutrition can drive-thru YOU to overeat evermore empty calories, disrupt your weight-managing and nutrientprocessing gut biome, and set you up for everything from Type 2 diabetes to heart disease and some forms of cancer.

Power up your nutrition: There?s a lot you can do to make sure you get the nutrition you need without overeating, even as your food supply dips in nutrients.

--Opt for locally grown, organic (if you like) seasonal veggies that haven?t been picked, kept super cool (apples and pears may be stored for up to 12 months), shipped halfway around the world (that takes weeks) or trucked across the country (five to seven days) and then delivered to the grocery store to languish until you buy them. Then they may sit in your fridge for a week before you eat them. Why that matters: Green peas stored around 33 F for seven days (a lot colder than most fridges) lose 15 percent of their vitamin C; green beans lose 77 percent! And that?s just the tip of the iceberg (lettuce)!

--For non-local, non-seasonal produce, it?s fine to consider frozen; it may have more nutrients than long-ago-picked fresh produce.

--Make very sure you get seven to nine servings (think handfuls) of produce daily. Most folks get so little produce that upping the ante to that level has huge, immediate health benefits.

--Upgrade your snacks: Have sliced or diced fruit and veggies on hand; enjoy nonfat, no-added-sugar yogurt with fresh fruit; drink beverages without any added sugars or syrups.

--Take a daily multivitamin (half in the morning, half at night) with nutrient doses that are around recommended levels (avoid megadoses of anything); take 900 mg of omega-3 DHA daily or eat salmon, sea trout, mackerel or anchovies two to three times a week; take 1,000 IU of vitamin D-3 (and get your blood level checked to see if you are deficient).

--Then, help your body to use the nutrients to improve your health and well-being: Go for 10,000 steps a day or the equivalent, and two to three 30-minute strength-building sessions a week.

Increased muscle tone burns the nutritional fuel you provide to help strengthen your immune and cardiovascular systems and brainpower. *** Mehmet Oz, M.D. is host of ?The Dr. Oz Show,? and Mike Roizen, M.D. is Chief Wellness Officer and Chair of Wellness Institute at Cleveland Clinic. To live your healthiest, tune into ?The Dr. Oz Show? or visit www.sharecare.com. ? 2017 Michael Roizen, M.D. and Mehmet Oz, M.D. Distributed by King Features Syndicate, Inc.

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He abandoned his teenage dreams of becoming a doctor when his high school guidance counselor told him he wasn’t smart enough to go to medical school.

Instead, he joined the U.S. Marine Corps. “I was looking for a challenge,� Osborn said. “It was probably the best experience of my life, and it’s the reason I am where I am today. The Marines taught me discipline and responsibility and how to be part of a team.�

The road from rebellious teen to family medicine physician has been long and winding for Dr. Kilby Osborn. It included stops in a group home for boys and the Marine Corps. He even sold frozen food and insurance policies before choosing a career in medicine. “I think that my story is a testament to say that, whatever your circumstances, with hard work and perseverance there is the potential to change your life,� Osborn said.

After his relationship with his adoptive father deteriorated, Osborn ended up spending his high school years in a group home in Massachusetts. “I learned a lot being there,� he said. “I had great mentors. It helped me build a better relationship with my parents. Sometimes when you’re in the middle of a situation, you can’t see past the end of your nose.�

council with the Medical Association of Georgia. “I think it’s really important for young physicians to be involved in the policy side of medicine to make sure their voices are heard,� he said. “If they don’t advocate for their profession and their patients then the responsibility will be left up to others who don’t understand what they and their patients go through on a regular basis.�

Osborn was excited to join the Phoebe Family Medicine Residency. He was After his military service, Osborn took looking to move south and he wanted a jobs selling insurance and Schwan’s program where he could get a lot of frozen food in Pennsylvania while he hands-on experience, but it was the planned how to take advantage of a full college scholarship thanks to his military people here who sold him on the program. “It was the interview process. service. A discussion with a physician I felt really at home with the residents about his early interest in medicine put him on a clear path. “He told me medical who were already here, and I thought it was a place where I could make a school is not about being smart. It’s about difference,� he said. being driven. If you can do that in the Marines, you can do that in school.�

Osborn should be back in uniform soon.

He has applied to serve as a physician in Osborn earned an undergraduate degree the Army Reserves. “I feel that’s the best from Southern Illinois University before way I could give back to the military for excelling in medical school at Indiana all it’s given me,� he said. After he University where he also earned a finishes his residency, he hopes to open a master’s degree in public health. “I like to clinic that will focus on the needs of boys use my interest in health policy to help and young men. “Not a whole lot is done shape healthcare locally,� Osborn said. to make sure they go to the doctor. I’d “People talk all the time about policy on like to open a clinic where I see patients the federal level, but healthcare starts in from 11 to 20 years-old, especially males, your community with your neighbors to help them transition from being a having access to a physician.� child to an adult.� He knows that difficult road well, and a clinic to help Osborn helped craft healthcare legislation young men make that transition as a medical student in Indiana, and he successfully would be one more stop on currently serves on a resident governing Kilby Osborn’s extraordinary journey.

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The Georgia Prostate Cancer Coalition (GPCC) and its partners are offering free PSA screenings to first responders including members of ALL Police, Sheriff, and Fire Departments across the state of Georgia. First responders may be screened by simply walking into your local Urology office- most of which are participating in this Prostate Coalition effort.

Be on the lookout for upcoming free screening events coming to a center near you. Men must be over the age of 40, and would expect to stay no longer than 15 minutes for a blood draw.

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Take care of your health with Finger’s Magic Touch called Mudra Science. According to the Vedic culture of ancient India, the world is made of ‘the five elements’ The five elements being Earth, Water, Fire, Wind and Space/ Vacuum. These five elements constitute the human body – the nutrients from the soil (earth) are absorbed by the plants which we consume (thus we survive on the earth element), the blood flowing through own veins represents the water element, the body heat represents the fire element, the oxygen we inhale and the carbon dioxide we exhale represents the wind element and the sinuses we have in our nose and skull represent the space element.

Each of these elements are related with one another in the human body. If any of these element is imbalanced ,disease and suffering occurs.

The command and control center of all these five elements lies in our fingers. So literally, our health lies at our fingertips. By touching or by pressing our fingers on each other in a particular fashion we can perform different Mudras.Thus by just keeping our fingers in a particular position, the imbalance in the five elements can be regulated .Regular practice of mudra therapy can balance the five

elements and make us healthy.

The five fingers of our hand represent these five elements Finger’s name The element it represents Thumb Fire Index Wind (AIR) Middle Space Ring Earth Little Water

Simply touch the tip of the thumb with the tip of the index finger,with the other three fingers stretched out.

Pressing is not necessary.

This can be practiced as long as possible. There is no time limit for this mudra. You can do it with both hands while walking, sitting, standing,watching TV,laying down whenever you have time.

It helps to increase the memory and sharpens intelligence. Regular practice of Gyan mudra can help psychological disorders like

Simply place your tip of index finger on the base of thumb and press with thumb.

The practice of this mudra decreases the level of the wind or air element within the body.

In acute cases 15-30 minutes of practice gives benefits.

Chronic diseases of (vata) ,gas needs practice of this mudra for 15-45 minutes daily.

Results show slowly but surely.

The Vayu Mudra is beneficial in relieving the neck pain caused by excess gas in the body. One may perform this mudra and rotate their wrist in order to relieve the neck pain.

This mudra also helps in alleviation of stomach distension and bloating.

This mudra has shown positive results in reducing the symptoms of diseases like

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