Pharma & Healthcare News June 2010

Pharma & Healthcare News Alsiano No. 12 • June 2010

Contents Organic ingredients................1 REBATEN - natural high intense sweetening.................2 Arolia - exclusive concentrated Acai extract.......3 Vitafoods 2010 - news from our suppliers...................4 4 effective trendy extracts from Afriplex...........................5 New innovative ingredient for ODT..................7 News in brief...........................8 The Alsiano Healthcare team.........................................8

Organic ingredients Get an overview of our range of organic ingredients for health supplements and nutraceuticals Alsiano is currently developing our product portfolio in accordance with the future needs and trends. We now see tendencies towards use of organic ingredients in the health supplements and nutraceuticals industries.

Therefore, we are presently expanding our range of organic ingredients.

Right now, we can offer the ingredients below in an organic version. This list will become more comprehensive in the years to come. Please do not hesitate to contact Alsiano if you have a need that isn’t on the list.

Organic inulin fibres from agave The agave fibres are made from organically grown agave plants which naturally contain 25% inulin. It is a white powder with neutral taste and excellent solubility. Applications: slimming, digestive health.

Organic agave syrup The agave syrup is made from the “quiote” (juice) of organically grown agave plants. The gentle production process makes sure that the “raw” properties of the agave syrup are preserved. Agave sirup is available in 4 different grades. Applications: sport nutrition, nutrition bars.

Organic baobab fruit pulp powder Baobab is a superfruit. The natural fruit powder is free-flowing, milled

Publisher: Alsiano A/S Circulation: 650 copies Editor-in-chief: Anders Hager Coordinator, text, lay-out: Dorthe Andersson Pharma & Healthcare News is published twice a year and distributed to customers and other interested parties. Reproduction of articles appearing in Pharma & Healthcare News requires prior consent of the author. Alsiano is not responsible for the content of articles written by external authors.

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and sifted. It has a high pectin content, useful for binding and thickening, and is also high in dietary fibre.

Applications: meal replacement, nutritional bars and drinks.

Organic rice starch The rice starch creates a soft and stable gel and is available in a native and a pregelatinised version. Applications: starch-based excipients for tablets, sport nutrition (carbohydrate source).

Organic plant extracts We offer more than 50 different organic extracts – e.g. rooibos, aloe vera, artichoke, green coffee, blackcurrant, milk thistle, and cranberry.

Applications: food supplements.

Organic vegetable oils We offer a wide range of vegetable oils from different sources. They are also available in powder form for tablets and powders. Applications: health supplements, sports nutrition, meal replacements, nutrition bars, tablets, capsules.

If you require a specific product that is not listed here, please contact us, and we will do our best to support you. We may already be in touch with a potential supplier.

Article 351

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REBATEN – natural high intense sweetening With a forthcoming European approval of stevia, Seppic is ready with an interesting range of this natural high intense sweetener, which is well suited for e.g. food supplements, drinks and pharmaceuticals

By Thierry Liot, Stevia Development Manager, Seppic In September 2009, the French government approved stevia extracts with 97 % purity Rebaudioside A (Reb A) as food and beverage sweeteners by inter-ministerial decree, taking advantage of a two year window that allows approval ahead of the rest of the EU. This has given the French company Seppic a great opportunity to achieve useful experience with the use of this natural high intense sweetener.

Legal status in EU Stevia is not approved in EU yet, but just a few months ago the expert panel of the EFSA (European Food Safety Association) expressed a positive recommendation on the use of steviol glycosides in foods and beverages, emphasizing quality standards as expressed by JECFA (Joint FAO/ WHO Experts Committee on Food Additives). This document is paving the way to a European approval, expected by end 2010 or early 2011.

The REBATEN range Based on the recommendations expressed in this document, it is SEPPIC’s intention to propose 4 JECFA-compliant grades for industrial appli-

cations (food, beverages and pharmaceuticals) and one specific grade for a ready-to-use powder table top sweetener – see table below. With these 5 grades, Seppic covers the entire panel of applications that European producers are looking for (taste profile, corresponding to application, manufacturing constraints, cost/ sweetness ratio, …).

REBATEN 97% in food supplements and drinks Due to its great stability and solubility, REBATEN 97%, Stevia extract, can easily be used in low-calorie or no sugar added food supplements. The maximum usage dosage (expressed in Rebaudioside A) authorised by French regulation is as follows: • Liquid food supplements - 600 mg/kg • Solid food supplements - 2000 mg/kg • Vitamin- and/or mineral-based food supplements in syrup or chewable form - 5500 mg/kg

vitamin-enriched drinks, etc. This also makes it ideal for formulating low calorie or no added sugar drinks.

REBATEN 97% advantages • Improved flavour • No sugar, fewer calories! Reduced calorie content • Low glycaemic index • 100% natural origin (Stevia plant extract) • Ideal for formulating sugar-free food supplements Industrial benefits • Intense sweetness • High stability in terms of pH, light and heat • Water soluble • Non fermentable • Good digestibility continues on page 3 >>

Likewise because of its great stability and solubility, REBATEN 97% Stevia extract can be used as a natural sweetener in a wide range of drinks like slimming drinks, energy drinks, Reb. A (%) min.

Typical total steviol sweetness glycosides % factor

Description

Appearance

Rebaten 97

Premium grade

White crystalline powder

97

97

300

Beverages, dairy, table top sweeteners and other applications wherein a premium taste is required

Rebaten 90

Standard high purity grade

White crystalline powder

90

95

270

Beverages

Rebaten 80

Medium grade for applications with White crystalline strong cost constraints and with powder other ingredients in the end-product formula that can hide off-taste

80

95

240

Bakery, dietary supplements, pharmaceuticals

Pharmaceuticals, marinated products, pickles and seasoning

Steviten Light Blend of stevion glycosides

White crystalline powder

10

95

150

Sweepia Light Blend of high purity Rebaten 97 with Erythritol and a natural aroma

White crystalline powder

3

3

5

2

Applications

High quality table top sweetener in spoonable form

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Arolia – exclusive concentrated Acai extract One gram of Arolia, which is equivalent to 2,700 ORAC units, covers 65% of the recommended daily antioxidant intake. Arolia can therefore easily complete the other antioxidant sources to reach the recommended level

By Seppic

Arolia is a natural exclusive extract of acai berries containing 2% proanthocyanidins. The extraction process, developed by BIOPHYTIS, is specifically designed to preserve and concentrate the most interesting components of the acai berry. Arolia’s antioxidant capacity is triggered and its content in lipids is reduced in comparison with acai berry and freezedried acai pulp.

Traceability and sustainability is totally implemented from the plant to the extract. Plants are strictly selected and the acai is harvested and produced in Brazil. BIOPHYTIS extraction plant is located in Atibaïa, Brazil.

Being an alimentary extract of the edible part of a food plant, Arolia has been approved as a food ingredient

by French regulatory authorities, and can therefore be used for dietary supplements and functional foods.

>> Quality Commitment To ensure the confidence and satisfaction of its customers in accordance with regulatory requirements, SEPPIC has a sustainable progress policy focused on the control of risks and a Quality Hygiene Safety and Environmental management system.

As a partner of the pharmaceutical, nutrition, and cosmetics industry, SEPPIC integrates and implements all relevant reference systems in its management system.

Article 353

Health benefits of Arolia Anthocyanins and proanthocyanidins are Arolia’s active principles. They belong to a specific group of polyphenols called flavonoids and have a high antioxidant activity. ORAC (Oxygen Radical Absorbance Capacity) assay is the most commonly used method to evaluate the antioxidant activity of a product. This assay was performed to compare the antioxidant capacities of Arolia, its raw material (acai pulp) and several fruit pulps whose ORAC values are indicated in the Antioxidant U.S. Department of Agriculture database published in 2007.

Characteristics • Proanthocyanidins: 2% • ORAC: 2,700 µmol TE/g • Red-purple fine powder • Water soluble • Taste/odour is characteristic of the fruit • Heat stable up to 80°C for a few seconds • Labelling: acai extract, cassava flor

Acai pulp has the highest ORAC value among other black/purple pigmented fruits. Moreover, Arolia antioxidant capacity is respectively 2 and 27 times higher compared to freeze dried acai and acai pulp, respectively.

These data show the importance of the extraction process designed to concentrate acai specific components responsible of the high antioxidant effects in Arolia.

Recommended dosage: 1g/day

In conclusion, one gram of Arolia is equivalent to 2,700 ORAC units and covers 65% of the recommended daily antioxidant intake.

Applications • Beverages • Dairy products • Ice cream • Dietary supplements

Article 352 About acai Acai is the fruit of the palm tree acaizeiro which is typical from Amazonian lands. Acai berries have been traditionally consumed by native Americans from this region and have been recognised as healthy food due to their number of active principles with health benefits: fibres, monoand poly-unsaturated fatty acids, phytosterols, phenolic compounds, vitamins and minerals.

About stevia Better known simply as stevia, Stevia rebaudiana is a wild herb which originates from the sub-tropical forest located on the border of Paraguay and Brazil. However, today, stevia is also cultivated in East Asia, including China, Korea, Taiwan, Thailand, and Malaysia.

Steviol glycosides are what give Stevia leaves their sweet flavour. These compounds are 40 to 300 times sweeter than sucrose (table sugar). Among all steviol glycosides contained in the Stevia leaves, the following can be mentioned: • Stevioside represents 5-10% of the dry matter (250 – 300 times sweeter than sugar). This substance has a bitter, mentholated taste.

• Rebaudioside A represents 2- 4% of the dry matter. This is the sweetest substance (200 to 400 times sweeter than sugar), and it has no bitter taste.

• Rebaudioside C represents 1- 2% of the dry matter.

• Dulcoside A represents 0.5-1% of the dry matter.

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Vitafoods 2010 - news from our suppliers Vitafoods 2010 offered many interesting products and news from Alsiano’s suppliers such as microencapsulated solubiliser, baobab and rosehip extract for e.g. beverages, selenium-enriched yeast and microalgae

Vitafoods 2010 is over for this time.

Visitors came from all over the world to visit the exhibition which hosted over 500 international exhibiting companies. Here is a brief overview of what our suppliers chose to showcase at Vitafoods 2010: Roquette: Much more than just ingredients The Roquette group presented its ingredients, active agents and excipients. Reflecting the group’s wellknown scientific and technical skills, they offer the nutraceutical industry the opportunity to achieve its ambitions both more creatively and more quickly.

Today, nutrition and health are everyone’s priorities. Always responsive to such priorities, Roquette is: • Helping bring about better balance in nutritional intakes with its range of NUTRALYS® proteins of vegetable origin (the pea) and its NUTRIOSE® fibres (from wheat and maize). Likewise its microalgae product ALGOMED®, and specifically Chlorella, with its unique nutritional composition.

• Opening up new perspectives in the fields of satiety and digestive health with its NUTRIOSE® fibres.

Its NUTRALYS® proteins also have a natural role to play in the satiety field.

• Contributing to the uptake of lutein, a pigment involved in ocular health. Based on a new luteinrich form, this Chlorella is a recent addition to the Roquette range.

• Offering a range of high-performance excipients through its complete range of DC Polyols (mannitol, maltitol, sorbitol, xylitol) newly completed with PEARLITOL® Flash, a mannitol compound made from two natural origin ingredients for orodispersible tablets technology, and LYCOAT® - a film-forming starch for original coating solutions.

New microencapsulated solubiliser from Seppic SEPPIC’s latest innovation is dedicated to oral solid drug formulations, in which solubilizers are needed. A new innovation is SEPITRAP™, microencapsulated solubilizer (MES), which opens up new possibilities for utilising more effectively poorly water soluble drugs, by improving their solubility and thus their bioavailability.

SEPITRAP™ is supplied in powder form and can be used in direct compression. It is recommended for tablet formulations up to 20% (SEPITRAP™ 80) and 15% (SEPITRAP™ 4000). It is also possible to use this new MES to formulate capsules.

SEPITRAP™ meets all the requirements of the current USP/NF regarding manufacturing of pharmaceutical ingredients.

Lesaffre – EFSA approved selenium enriched yeast Lesaffre showcased Lynside® Forte Se +1200 and Se +2000, seleniumenriched yeast, which is an excellent ingredient for antioxidative and immune formulations. The products contribute to the protection of body cell constituents from oxidative damage, the normal function of the im-

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mune system, normal thyroid function and normal spermogenesis.

Lynside® Forte selenium has high bioavailability and is authorised in foods - including food supplements – at a European level.

Afriplex - rose hip & baobab At Afriplex’s booth, the focus fell on two of their extracts: rosehip and baobab which are suitable for e.g. drinks. Baobab offers opportunities for improvements in the overall nutritional profile of various products.

For instance, it contains higher levels of calcium than milk, other fruits and “superfruits”. Of other key nutritional properties it is also worth mentioning that baobab has a high content of dietary fibre, antioxidants, iron, potassium and magnesium.

Rose hip is regarded as a natural herb and is an excellent source of vitamins A, D, E and C as well as a range of antioxidant bioflavo- noids. Rose hip can be used in a wide range of applications and is available as powder extract, finely milled powder, and oil. Read more about rose hip and other products from Afriplex on page 5.

New SEDOX® dry extract from EPO EPO introduced their brand new SEDOX® dry extract with double standardisation, i.e. 1% verbascoside and 5% total phenols.

This extract has been developed by EPO as a completion of their SEDOX® range, which already includes the fluid extracts available both with and without ethanol. Besides its antioxidating action, this extract is recommended ... continues on page 5 >>

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4 effective trendy extracts from Afriplex Afriplex offers a wide range of plants extracts made from plants indigenous to the African continent. Among these are Buchu, Pelargonium sidoides and Irvingia, which - together with Rose hip - are of great interest at the moment for health supplements due to recently published studies

By Annette Strarup, Area Sales Manager, Alsiano Pelargonium sidoides for immune health/colds The Pelargonium is successfully employed in the modern phyto-therapy in Europe to cure infection diseases in the respiratory tract. Until recently, a German company have had monopoly on Pelargonium supplements, but their patent expired last year and Pelargonium extract is thus now available for use for everybody.

Besides extract in powder form, Pelargonium sidoides from Afriplex is also available as a liquid solution. Applications: tablets, capsules, mixtures.

Irvingia extract for weight loss for the US and Asian market Irvingia extract is now available from Afriplex, due to high demand from Rose hip

Buchu

Pelargonium is a South African indigenous plant and has been used for centuries by the Zulu as a traditional remedy in the treatment of upper respiratory tract irritations such as cough, fever and bronchitis. In the 19th century, the South African drug ‘Umckal abo’ became known in Europe Pelargonium where the pink-flowered Pelargonium renifine and the very similar the US and the Asian slimming marbut dark maroon-red flowers of Pelket. However, Irvingia is not formally argonium sidoides are ingredients in approved in EU yet. a German medicinal remedy called ‘Umckaloabo’.

Irvingia garbodensis is the official Modern human studies comprise two relatively new ones: a study on common colds from 20071) and a study from 20032) on the efficacy on acute bronchitis.

name of the West African fruit tree commonly known as bush mango or African mango. The seeds of the bush mango contain water-soluble dietary fibres that delay stomach

>> for treatment of diseases of the respiratory tract, thanks to its expectorant, bechic and antispasmodic properties.

there are a number of existing regulations that concern mineral salts.

Jost European regulations are getting more and more precise and restrictive regarding the levels of contaminants in food and nutritional products. As far as heavy metals are concerned,

emptying and allow for a more gradual absorption of dietary sugar. Initial studies have suggested that the high fibre content of Irvingia accounted for its beneficial metabolic effects, but recent animal studies suggest other factors as well. Researchers are studying Irvingia for its potential use in treating diabetes, metabolic syndrome and obesity.

Jost Chemical has been producing guaranteed high-purity minerals for nearly 25 years and is now also wellknown for having developed a new technology for the manufacturing of ultra-pure calcium salts for infant formulations and drink applications.

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In a study of 40 obese Cameroonian patients done in 2005, significant decreases of body weight, total cholesterol, LDL or ‘bad cholesterol’ and triglycerides were observed by the end of the 10 weeks’ study. A 2008 study based on 102 obese patients3) indicated similar results with lower dosages of Irvingia extract. 150 Irvingia mg seed extract twice a day for 10 weeks reduces weight by 13 kg compared to 0.7 kg for placebo. More evidence is needed about long term safety and efficacy, but already now Irvingia is a popular natural ingredient for weight loss especially in the US. Irvingia is available in powder form.

Applications: tablets, capsules, chewing gum. Continues on page 6 ...>>

Article 354

Pharma & Healthcare News Food News

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No. 1No.• 12February 2004

No scientific evidence is available to justify Buchu´s herbal uses, but the diuretic and anti-inflammatoric effect may be attributed to the volatile oil and flavonoid’s irritant nature.

Despite the lack of evidence, buchu is still used today in western herbal medicine for urinary tract ailments.

It is also used in combination with other herbs such as cornsilk, juniper, cranberry and uva-ursi. >> Buchu for urinary tract infection Buchu (Agathosma betulina) is a low growing shrub native to Cape Town, South Africa. It is part of the cultural heritage of the San and Khoi people as a stomach tonic and to treat urinary tract infections. Today, Buchu is widely used as a household medicine in South Africa, with a great reputation for treating kidney and urinary tract diseases. Buchu was first exported to Britain in 1790, and in 1821 it was listed in the British pharmacopoeia as a medicine for ‘cystitis, urethritis, nephritis and catarrh of the bladder’. Buchu is also listed in German Commission E Monographs and has moreover been consumed as herbal tea in Germany for decades.

The main compounds in the essential oils of Buchu are isomenthone and diosphenol (Buchu camphor). The flavour oil of Buchu has a characteristic blackcurrant smell and flavour. The essential oils are generally used because of their antiseptic and diuretic properties. Buchu leaves also contain the flavonoids rutin, diosmin, hesperidin, and quecetin. The dry leaves are used in herbal preparations and contain around 3% essential oil.

Buchu from Afriplex is available as water extract spray-dried to maltodextrin, essential oil and ethanolic extract. Applications: tablets, capsules, cosmetics.

Rose hips for joint health applications Rose hips are the fruit of the rose species Rosa canina. The fruit is ready to be harvested when it changes colour from green to bright red during early winter in South Africa.

The fruit contains mono- and diglycerol (also known as G.O.P.O.) exhibiting anti-inflammatory properties and is therefore often used in joint health applications. Rose hip also contains an excellent source of vitamin C and antioxidant bioflavonoids. The cartonoids present in rose hips are betacarotene, lycopene, betacryptoxanthin, zeaxanthin, and lutein.

The benefits of rose hips have been known for centuries. Historians say the Vikings used rose hips to stave off scurvy on their long sea voyages and in the past, rose hips have been used across the world to treat a number of conditions, from arthritis, colds and flu to bladder stones and premature

Active

Properties

Name of extract

Botanical name

Pelargonium

Pelargonium sidoides Coumarins, scopoletin

Irvingia

Irvingia gabodensis

Seed fibre

Weight loss

Buchu

Agathosma betulina

Diosphenol, flavonoids

Urinary tract infections, flavour enhancer

Rose hip

Rose canina

Vitamin C, GOPO

Joint health

Baobab pulp

Adansonia digitata

Pectin, amino acids, polyphenols, vitamin C

Beauty from within, digestive health, energy booster

Rooibos

Aspalathus linearis

Asphilithin

Antioxidant, skin nutrient

Kigelia

Kigelia Africana

Steroidal saponins

Suncare

Aloe vera

Aloe vera

Aloin, polysaccharides

Digestive health

Aloe ferox

Aloe ferox

Aloin, polysaccharides

Digestive health

Devil’s claw

Harpaghytum procumbens

Harpagoside

Joint health

Immune health/colds

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Alsiano Alsiano Afriplex – the essence of Africa Afriplex is a strong player in the international plant extract market, specialising in extracting the essence of Africa. The company specialises in providing high quality plant extracts for beverage, pharmaceutical, cosmetic and other applications. The extracts are produced in client specific formats, thereby ensuring satisfactory practical application to the client.

ageing. During World War II rose hip syrup was an important source of vitamin C for children.

Over time, several studies have been made. A human study of a rose hip remedy called LitoZin4) showed possible benefits to rheumatoid arthritis sufferers. Seventy-four people, mostly females, took part in the six-month trial. Just under half took the rose hip remedy LitoZin while the others took a placebo. Both groups continued to take their usual medication.

According to results, activity among the group taking the rose hip remedy improved by 20-25%. The number of joints causing pain or discomfort fell by 40%, but did not change for those treated with placebo.

Rose hip from Afriplex is available in powder form and as essential oil.

Applications: tablets, capsules, beverages.

Article 355 References 1) Chuchalin, AG, Benan B, Lemacher, W : Efficacy of Pelargonium sidoides preparation in patients with common cold, Explore 2007, 3: 573-84 2) Heinrich Matthys : Efficacy and safety of an extract of Pelargonium sidoides preparation in adults with acute bronchitis, International journal of Phytotherapy and Phytopharmacology, May 1, 2003.

3) J.L. Ngondi, B.C. Etoundi et al : IGOB131, a novel seed extract of the West African plant Irvingi gabodensis, significantly reduces body weight and improves metablic parameters in overweight humans, Lipids in Health and Disease, 2009, 8:7 4) Willich SN, Rossnagel K, Roll S, et al. “Rose hip herbal remedy in patients with rheumatoid arthritis - a randomised controlled trial”. Phytomedicine 17 (2), February 2010: 87–93.

Pharma & Healthcare News

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June 2010

Alsiano

New innovative ingredient for ODT PEARLITOL® Flash is a new innovative compound excipient from Roquette for successful development of fast disintegration formulations such as orodispersible tablets PEARLITOL® Flash offers a technology that enables successful development of fast disintegration formulations such as ODT by providing: • • • • • •

By Anders Hager, Sales Manager Healthcare, Alsiano, & Elham Blouet, Pharmaceutical Project and Development Manager, Roquette.

What kind of technology can achieve a fast delivery of active ingredients inside the mouth in 2 ml of water?

The orodispersible dosage form has the characteristic feature of requiring neither water nor chewing during its administration - orodispersible tablets (ODT) disintegrates in the presence of saliva.

ODT are uncoated tablets intended to be placed in the mouth where they disperse rapidly before being swallowed. Besides the fact that the ODT dosage form is one among other means of extending the product lifecycle, this modern medication delivery system offers various benefits: • Easy to swallow – e.g. geriatric and paediatric populations • On-the-go use – does not require drinking water as with a conventional tablet • Better patient compliance - e.g. attractive mouth-feel PEARLITOL® Flash: An innovative compound excipient Based on their wide experience with mannitol (PEARLITOL®), Roquette has developed an innovative binary compound excipient, PEARLITOL® Flash, which is composed of mannitol and maize starch.

A uniquely pleasing taste Fast melting in the mouth Smooth texture An easy DC tabletting process A robust DC excipient A surprisingly simple formulation

PEARLITOL® Flash provides a uniquely pleasing taste experience. The orodispersible tablets melt in the mouth with a very creamy and smooth texture.

Contrary to usual orodispersible formulation tablets, no superdisintegrant is needed, since PEARLITOL® Flash mannitol compound exhibits self-disintegration properties. In addition, a low lubricant level (0.4%) is sufficient to achieve good compression performance. This low level is beneficial to maintain the pleasant taste of PEARLITOL® Flash, whereas a high level of lubricant could compromise it.

Fast melting in the mouth Orodispersible tablets formulated with PEARLITOL® Flash, 0.4% of lubricant (magnesium stearate) and active substances from 2% up to 30%, display a very quick disintegration time (Eur.Ph. method): 50-80 sec onds. This disintegration time is far below the “within 3 minutes” disintegration time required by the Eur.Ph. for orodispersible tablets.

Directly compressible Thanks to its excellent compactibility, PEARLITOL® Flash makes possible the manufacture of good mechanically resistant tablets by direct compression.

Under studied conditions, Korsch XP1 press fitted with 13 mm diameter flat bevelled-edge punches, 15kN compression force was sufficient to obtain 500 mg orodispersible tablets with acceptable hardness, friability and disintegration time characteristics.

Regulatory status The use of PEARLITOL® Flash in fast disintegrating tablets or orodispersible formulation tablets is suitable for both pharmaceutical and nutraceutical applications. PEARLITOL® Flash is a compound of mannitol and extra white maize starch. Both ingredients comply with pharmaceutical compendial standards and food regulations. A US DMF type IV (excipient) is registered at the FDA. PEARLITOL® Flash – ideal for ODT To sum up, the requirements for the ideal excipient in ODTs are good compatibility, fast disintegration and a nice mouth-feel (sweetener).

PEARLITOL® Flash is an excipient that possesses all these abilities.

Article 356

PEARLITOL® Flash

Rapid disintegrant Disintegrant

Nice mouth-feel Sweeteners

Robustness Highly compressible filler © - Roquette Fréres

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Pharma & Healthcare News

No. 12

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June 2010

Alsiano

The Alsiano Healthcare team It is always nice to be able to put a face on the person you talk to over the telephone or e-mail. So here we are ...

Pharmaceuticals - cosmetics health & nutrition

Key accounts

Pharmaceuticals - cosmetics health & nutrition

Anders Hager

Lene Aarøe Nissen

Annette Strarup

M.Sc. Chem.

Sales manager

B. Chem. Eng. Area sales manager

B.Sc. (Hons.) Chem. Eng. Area sales manager

E-mail: ahg@alsiano.com Tel. dir.: +45 8230 0026 Mobile: +45 2618 8545

E-mail: lan@alsiano.com Tel. dir.: +45 8230 0025 Mobile: +45 2270 1002

E-mail: ask@alsiano.com Tel. dir.: +45 8230 0049 Mobile: +45 2270 1015

Pharmaceuticals - Fermentation

Sales support

Sales support

Annette Jarlskov

Signe Mørck

Birgitte Falkensteen

M.Sc. Food Science Area sales manager

Sales assistant

Sales assistant

E-mail: aja@alsiano.com Tel. dir.: +45 8230 0072 Mobile: +45 2270 1017

E-mail: sm@alsiano.com Tel. dir.: +45 8230 0042

E-mail: bf@alsiano.com Tel. dir.: +45 8230 0006

Sales support

Logistics Malene Rask Harder

Lene Baldasano del Valle

Sales assistant

Logistics manager

E-mail: mrh@alsiano.com Tel. dir.: +45 8230 0007

E-mail: lb@alsiano.com Tel. dir.: +45 8230 0015

News in brief: Centralisation of stock activities at Karlslunde We are pleased to announce that all our stock facilities in Denmark have now been united at one location at our warehouse in Karlslunde, south of Copenhagen.

This warehouse will from now on function as the central warehouse for Alsiano Healthcare and Alsiano Food in the Nordic countries. The stock for Alsiano Industry is still located in Gothenburg. This new structure will secure a more efficient distribution of goods.

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Have an summ ice er!