Pharma & Healthcare News Alsiano No. 22 • June 2016
Contents BENEO secures 2nd authorised 13.5 health claim in 2016 for its chicory root fibres .............1 Vitafoods 2016: news from our suppliers ........3 SEPIFITTM Protect recovery & performance.........5 Micro nutrient mineral blends .....................................6 Jost booklet about minerals...................................6 A natural alternative to support bladder wellness ......7 DNA certified extracts from EPO ................................8 New vegan protein for beverages and bars.................9 New - calcium citrate for chewable tablets ..................10 The Alsiano Healthcare team ......................................10
BENEO secures 2nd authorised 13.5 health claim in 2016 for its chicory root fibres Inulin and oligofructose contribute to a reduction in blood glucose rise By BENEO Starting 20 June, customers working with Orafti® Inulin or Oligofructose can launch products with the following attractive claims: “Lower and more balanced blood glucose rise” or “lower impact on blood glucose levels” in combination with the official EU 13.5. health claim. The official claim wording is as follows: “Consumption of [e.g. breakfast cereals] containing inulin and oligofructose instead of sugars induces a lower blood glucose rise after their consumption compared to sugarcontaining [e.g. breakfast cereals].” This succeeds BENEO’s first 13.5 health claim on digestive health for its chicory inulin which came into force at the beginning of 2016.
Publisher: Alsiano A/S Circulation: 500 copies Editor-in-chief: Anders Hager Coordinator, text, lay-out: Dorthe Andersson Pharma & Healthcare News is published twice a year and distributed to customers and other interested parties. Reproduction of articles appearing in Pharma & Healthcare News requires prior consent of the author. Alsiano is not responsible for the content of articles written by external authors.
1
The recent health claim confirms that inulin and oligofructose contribute to a better blood glucose management as they support a lower rise in blood glucose response. A 30% sugars reduction needs to be obtained by replacement by non-digestible carbohydrates such as BENEO’s inulin and oligofructose according to the conditions of use. The authorisation is based on several scientific studies all of which confirm that oligofructose and inulin have a significant part to play in the area of glycaemic control. About 422 million people worldwide have diabetes, a number that is likely to more than double over the next (continues on page 2 >>)
Pharma & Healthcare News Food News
• June 2016 No. 1No.• 22February 2004
identifying the respective products and also helps manufacturers to develop a greater variety of low glycaemic choices in response to this consumer need. BENEO’s inulin and oligofructose, derived from chicory root, contribute to a lower glycaemic response of food and drink products because they are not digested in the human digestive system and thus no glucose is released into the blood stream. Replacing high glycaemic ingredients (e.g. sucrose, glucose, maltodextrin) using BENEO’s dietary fibres, which do not cause a glycaemic response, consequently lowers the blood glucose response of the final product and adds a valuable fibre source at the same time. ©BENEO
>> 20 years. More than 90% of these
people suffer from diabetes type II so preventative measures, such as healthy eating, are a key area of concern. Leading scientists agree that a low glycaemic diet reduces the risk of type II diabetes and helps to control blood glucose levels, a factor that is particularly important for people who already suffer from diabetes. Consumer awareness around the issue is growing and as a result, many more consumers are now seeking out low glycaemic products. The new health claim supports them in more easily
Anke Sentko, VP Regulatory Affairs and Nutrition Communication at BENEO: “Blood glucose management is a key element in the promotion of longterm health from early on. Consumers are increasingly aware that carbohydrate-based, low glycaemic products contribute to healthy nutrition. The new health claim for BENEO’s dietary fibres inulin and oligofructose confirms once again the strong scientific evidence behind our ingredients. But, even more important than that, it offers manufacturers the opportunity to help consumers make better choices in their daily diet that support a low glycaemic nutrition.” Article 419
Blood glucose response for food with chicory root fibre compared to food with sugar
©BENEO
22
Alsiano Alsiano
Exclusive 13.5 digestive health claim on Orafti® Inulin Customers working with Orafti® Inulin can launch products with a claim on pack promoting digestive health. The 13.5 health claim came into effect as of 1 January 2016. The official wording for the claim is “chicory inulin contributes to normal bowel function by increasing stool frequency”. In addition general health-related well-being claims under article 10.3 are also possible. Amongst others, these include “chicory inulin promotes digestive health” or “chicory root fibre supports a healthy and balanced digestive system”. With the health claim for BENEO’s chicory inulin improving bowel function, food manufacturers are well set to make the most of the ever growing consumer trend of digestive health.
Pharma & Healthcare News
No. 22
•
June 2016
Alsiano
Vitafoods 2016: news from our suppliers A wide range of Alsiano’s suppliers showcased their latest innovations at the recent global nutraceutical event
From 10-12, May the Vitafoods Europe show took place in Geneva with 900 suppliers showing their latest innovations within ingredients, raw materials, products and technologies to approx 18,000 buyers, influencers, scientists, and R&D professionals.
Frutarom presented various interesting health ingredients including AB Fortis microencapsulated iron for iron fortification, which does not have the metallic taste and unpleasant gastro-intestinal tract side-effects that is often associated with iron supplements. Other products shown were Neuravena green oat extract for mental fitness and cognitive performance in stressful situations, Mentarillo contributing to the improvement of memory, learning and mood, Citr-Olive for cardiovascular health and Nutrafur citrus extracts including CitroT, the soluble extract with high bioflavonoid content well suited for beverages.
Here is a brief summary of what our suppliers presented at Vitafoods: Davos, part of KLK OLEO, showcased their DavosLife Naturale3 Tocotrienols which are extracted from non-GMO palm oil fully traceable to the RSPO certified plantations of its parent company. They are 100% natural, using proprietary state-ofthe-art technology that maintains tocotrienols’ original chemical forms throughout the entire extraction and purification processes while ensuring the highest purity levels. They contain a balanced full spectrum formula of all four natural tocotrienol isomers (alpha, beta, gamma, and delta). This tocotrienol complex is gamma-tocotrienol rich, with no artificial additives or preservatives added. EPO has added a new extract to its product range, Violapur, which has a long history of use for skin care due to its soothing properties and anti-inflammatory action. Another topic at EPO’s stand was the company’s ever expanding range of DNA certified extracts (se more on page 8).
3
Grap’Sud showcased their range of grape and olive polyphenols: exGrape SEED, exGrape TOTAL and Olivex. exGrape SEED is a natural standardised procyanidins extract made from selected grape seeds harvested exclusively in France. exGrape TOTAL is a natural standardised polyphenols extract made from selected French grapes, offering guaranteed content of procyanidins, anthocyanins and resveratrol. This product presents a polyphenolic profile very similar to the one of red wine. Olivex, a natural standardised polyphenol extract made from selected French olives of-
(continues on page 4 >>)
Pharma & Healthcare News >> fers guaranteed content of hydroxyty-
rosol and tyrosol. Coming exclusively from the fruit, Olivex provides the benefits of the Mediterranean diet. Ingredia launched its new bioactive, PRODIET Lactoferrin, the purest lactoferrin on the market. Lactoferrin is a protein occurring naturally in milk and human secretions. This glycoprotein has a high iron binding capacity which provides antimicrobial activity. Moreover, Lactoferrin has shown real benefits in immune health, gut health, and skin health. Jost presented its broad range of high purity specialty chemicals for food, food supplements, nutrition and infant formulas. Among the products was the new granulated calcium citrate 80% which is developed specifically for chewable tablets enabling a non-gritty mouthfeel – see more on page 10). All Jost minerals comply with the strictest re-gulations in the food, nutrition, clinical and infant nutrition markets. KitoZyme offers solutions within weight management, digestive health and cardiovascular health. At Vitafoods, KitoZyme introduced Gastrap, which is a medical device combining the two actives: KiOtransine®& Simethicone and peppermint. Gastrap is intended for use for symptomatic treatment of gas-related GIcomplaints by favouring gas elimination, improving stool consistency and restoring healthy flora.
No. 22
•
June 2016
Alsiano
Lesaffre Human Care presented its newly launched Lynside® NUTRI ORGANIC, an inactive dried yeast (Saccharomyces cerevisiae) which can be considered as the new organic superfood. This product is an excellent source of non-animal protein; it is perfect for vegan-friendly diets and also a great source of vitamin B, fibres and minerals. Furthermore, Lesaffre showcased LifeinU LGG, the probiotic strain that has shown beneficial effects on digestive and immune health, and the immune health empowering probiotic with clinically proven efficacy, Bacillus Subtilis CU1. Ribus presented its range of natural and organic rice ingredients. Utilising its patented technology, RIBUS is committed to being the best supplier of high quality specialty rice ingredients that can replace synthetics (SiO2, soy lecithin, mg stearate, maltodextrin) and enable brands to have the clean label consumers are demanding. RIBUS’ products - Nu-RICE®, NuBAKE®, Nu-FLOW® and Nu-FLAC® are certified gluten-free, non-GMO, hypoallergenic, kosher/Halal, organic and vegan. Seppic launched SEPIFIT™ PROTECT, an ingredient dedicated to muscle recovery and protection. SEPIFIT™ PROTECT contributes to the protection of muscle cells against both fatigue and damage caused by sport, thus optimising recovery and performance for athletes. Its effectiveness is based on a complex synergy of ingredients
In the New Products Zone visitors could discover the latest ingredients and finished products to hit the market in the last 12 months.
selected to block cellular oxidation mechanisms and their harmful consequences on the cell (see more on page 5). Vidya Herbs, producer of high quality herbal extracts, essential oils and spice oleoresins, showcased their new highly bioavailable turmeric extract, Vi-Active, standardised at 95% curcuminoids and formulated with vege-table fats as natural bio-enhancers. Vi-Active is clinically proven to have more bioavailable curcumin than a standard extract. In-vitro assays have assessed the anti-oxidant, DNA-protective, anti-winkle, and skin-lightening activities of Vi-Active turmeric extract. Article 420
The Tasting Bar gave visitors the opportunity to see, touch and taste a variety of functional foods and beverages.
4
Pharma & Healthcare News
No. 22
•
June 2016
Alsiano
SEPIFITTM Protect – recovery & performance Seppic has launched a new active complex offering complete muscle protection against fatigue and damage induced by exercise By SEPPIC Intense or prolonged exercise induces multiple phenomena at the muscle cellular level translating into perceptible signs such as a decrease in strength or soreness. Ultimately, the athlete may note a decrease in performance, poor recovery and difficulties getting back to daily training. As a synergistic complex, SEPIFITTM Protect prevents both muscle fatigue and muscle damage at the cellular level. Central to this action lies a multiple antioxidant mechanism. SEPITFIT Protect contributes to limiting the negative effects of exercise and enhancing performance and recovery. Food supplements with SEPIFITTM Protect can easily be formulated and bring friendly and attractive concepts to the consumers.
Formulation made easy SEPIFITTM Protect has been specifically designed for food supplements taking formulators’ needs and particular constraints of tablet and capsules into account. It comes in a powder form with high stability guaranteeing good homogeneity in formulas. The recommended daily dose can easily fit in a single tablet or capsule for good consumer compliance. It is also compatible with stick packs and bulk powders for instant drinks. Thanks to its muscle protection benefits, SEPIFITTM Protect can be used in pre- and post-workout formulas or in multivitamins for active people. It can also bring an additional feature to products targeting performance. Article 421
SEPIFITTM Protect contributes to limit the negative effects of exercise and to enhance performance and recovery Proprietary in vitro data on key biomarkers of muscle fatigue and damage SEPPIC’s innovation center has developed a proprietary in vitro model able to mimic physical exercise and its consequences on human muscle fibres. The combination of antioxidants present in SEPIFITTM Protect significantly and greatly reduces the release of lactate and Interleukin 6 (IL-6) induced by exercise. It also significantly prevents the decrease of intracellular Creatine Kinase (CK) activity induced by exercise.
5
• Efficacy on key biomarkers of muscle fatigue and damage • Synergistic active complex • Proprietary in vitro model • Easy to formulate in food supplements • Approved for use in food supplements and in the EU/ authorised health claims • Approved for use in food supplements in the US • No GMO / no WADA substance / vegan • Manufactured in France
Pharma & Healthcare News
No. 22
•
June 2016
Alsiano
Micro nutrient mineral blends Celtic Chemicals offers a range of pre-blended high purity micro elements for dietary supplements allowing better dispersion Micro nutrient mineral blends (triturations) are an ideal way of incorporating micro elements into your product. When formulating dietary supplements, the inclusion of micro nutrient elements into the batch blending is extremely small compared to other ingredients, usually due to the very low recommended daily allowances for these elements. This can result in poor homogeneity and variable mineral content across the batch, but with the inclusion of pre-blended micro elements better dispersion across the entire batch is achieved. Working with Celtic Chemicals Celtic Chemicals manufactures micro elements triturated (blended) with excipients (carriers) on a completely
custom-made basis. The customer decides the quantity of active ingredient in every kilogram of blend and preferred excipient - maltodextrin, calcium phosphate or calcium carbonate (all excipients fulfil the purity criteria for food additives: Directive 2008/84/EU). The blend ensures easy and accurate dosing, homogenous distribution of the element in the finished product, and reduced toxicity, especially with Selenium blends. Raw materials are dispensed and manufactured in accordance with procedures prescribed in Celtic Chemicals’ integrated Quality Management System. The iQMS incorporates the principles of HACCP, Risk Management and Good Manufacturing Practice.
Blends are tested in-house for compliance to specification ICP/EOS and AAS. On approval, the blend is packed to customer requirements in food grade packaging. Minimum order is 25 kg packed in 5, 10 and 25 pack sizes. Article 422
Jost booklet about minerals A new minerals reference booklet from Jost provides an overview of the health benefits associated with calcium, copper, iron, magnesium, manganese and zinc Jost Chemical is now offering a 21page reference booklet, The Importance of Minerals in the Longterm Health of Humans. This booklet is meant as a reference for the health benefits associated with calcium, copper, iron, magnesium, manganese and zinc.
bute to the overall health of the individual. There are several other trace minerals requirements.
Daily intakes of several minerals are necessary for the continued basic functioning of the human body. The minerals Calcium (Ca), Iron (Fe), Copper (Cu), Magnesium (Mg), Manganese (Mn), and Zinc (Zn) are known to be necessary for proper functioning and growth of the many systems in the human body and thus contri-
In the Minerals Reference Booklet, each individual mineral is discussed with its functions in the human body and recommended dietary allowances (RDA) are listed. The booklet also touches on why the mineral discussed is required, which biological systems it supports and which Jost products can be considered to supplement these minerals.
Article 423
Contact us for a print copy or read online here:
6
Pharma & Healthcare News
No. 22
•
June 2016
Alsiano
A natural alternative to support bladder wellness Thanks to its urinary health promoting properties and excellent tolerance, Go-Less® is a valuable ingredient with highly attractive positioning opportunities in the growing market for urinary health supporting products By Frutarom Go-Less® is a natural alternative to support bladder wellness in men and women. It is carefully formulated from two natural ingredients: Pumpkin seed EFLA®940 and SoyLife®40%. EFLA®940 is a water-soluble pumpkin seed extract that contains the complete spectrum of polar and semipolar constituents of the seed. Frutarom uses the proprietary EFLA®HyperPure production process which ensures highly selective removal of the fat-soluble components from the extract, providing increased stability and solubility, and absence of rancidity. SoyLife® is a soy germ extract containing a standardised amount of isoflavones as well as other phytonutrients from soy associated with improved health.
Go-Less® health benefits The seeds of the medicinal pumpkin (Cucurbita pepo L.) have been used for centuries as a natural remedy for urination problems. Pumpkin seed EFLA®940 has been researched for many years and shown to be effective in the reduction of symptoms of overactive bladder and in the improvement of urinary health in women by supporting pelvic floor, sphincter muscles strengthening and relaxation of the bladder wall. In men who suffer from benign prostate hyperplasia, pumpkin reduces prostateinduced urinary symptoms by supporting the relaxation of the bladder wall and slowing down the growth of prostate tissue. Soy isoflavones act as phytostrogens and they are suggested to help balance hormone levels in the body and improve the elasticity of
Patented EFLA® Hyperpressure production process and the most researched soy germ extract.
the urethral wall in women suffering from overactive bladder and urinary incontinence. Three clinical studies conducted in Japan and one in Korea support the efficacy and safety of Go-Less® in addressing the cause of overactive bladder and urinary incontinence as well as reducing the symptoms. Article 424
Efficacy and safety supported by proprietary studies
Product information Standardised on phenolic derivatives (as Pyrogallol) 1.3-2.2%, Soy isoflavones ≥ 4.5 % Dosage: 600 mg/day
7
Pharma & Healthcare News
No. 22
•
June 2016
Alsiano
DNA certified extracts from EPO EPO Srl. offers a wide range of DNA certified botanical extracts There is a growing consumer and regulatory concern regarding the authenticity of dietary supplement ingredients. One area of concern has been about herbal/botanical products and whether they actually contain the botanical ingredient declared on the product label. That is where DNA testing comes in. DNA barcoding is a technique for characterising species of organisms using a short DNA sequence from a standard part of the genome; for plants three plastid (rbcL, matK, trnHpsbA) and one nuclear (ITS) gene regions are normally used as a standard barcode. The technique is very similar to a supermarket scanner which identifies products by reading the black bars of the UPC (Universal Product Code): the sample is identified by finding the
closest matching between the isolated DNA sequence and a reference sequence of an official barcode database. The DNA barcoding project has been developed with FEM 2 Ambiente S.r.l., a spin off of Milan Bicocca University; their labs represent one of the International Nodes of iBOL (International Barcode of Life); the iBOL Nodes are networks of leading researchers and key organisations affiliated to iBOL, using standard procedures to isolate and identify the DNA barcode. The DNA barcode is a unique pattern in every living being, therefore the DNA barcoding technique is more accurate than any other classical identification system or technique, such as taxonomy or TLC (Thin Layer Chromatography for plants). Article 425
EPO DNA certified extracts to date: • Bilberry (fruit) • Black elder (flower) • Butcher’s broom (root) • California poppy (aerial part) • Dandelion (root) • Fennel (fruit) • Iceland moss (thallus) • Lemon balm (leaf) • Marshmallow (root) • Passion herb (flowering herb) • Yerba mate (leaf)
8
Pharma & Healthcare News
No. 22
•
June 2016
Alsiano
New vegan protein for beverages and bars AlgaVia® Whole Algae Protein is a source of quality protein with the added benefits of insoluble fibre, healthy lipids and micronutrients such as lutein and zeaxanthin AlgaVia® Whole Algae Protein from TerraVia is a vegan source of protein which delivers a unique set of functional and nutritional benefits. As a whole food ingredient, it not only contains quality protein but also nutritious lipids, fibres and micronutrients. AlgaVia® Whole Algae Protein contains 60% protein and with all essential amino acids present, it is an excellent source of protein that can be included in e.g. beverages, readyto-mix powders and health bars.
by the cell wall making it a robust fortification tool that has limited interaction with other ingredients and is minimally affected by temperature and pH. This makes it excellent in the challenging low pH beverages where any grittiness from the protein is avoided too. Since it is vegan, gluten-free and free of known allergens, products fortified with the protein-rich whole algae are accessible to a wide range of consumers.
The protein and nutrients in AlgaVia® Whole Algae Protein are protected
Article 426
TerraVia™
is a nextgeneration food, nutrition and specialty ingredients company that harnesses the power of algae, the mother of all plants and earth's original superfood, to deliver innovation and sustainable solutions to the food industry. TerraVia's algae-based platform is transforming our food system by bringing together better nutrition and great taste, along with economic and environmental sustainability. The company has spent over a decade unlocking the power of algae to find and develop vital food, nutrition, and specialty ingredients: healthy oils and fats, proteins, fibres and micronutrients.
• Fortify with vegan ingredients • Whole food ingredient • Free of known allergens • Sustainable, naturallyderived • Contains all essential amino acids • High protein digestibility • Zero to minimal impact on the texture or viscosity of a finished product • Stable in a variety of temperatures and pH conditions
9
Pharma & Healthcare News
No. 22
•
June 2016
Alsiano
The Alsiano Healthcare team Anders Hager
Lene Aarøe Nissen
Annette Strarup
M.Sc. Chem. Sales director
B. Chem. Eng. Area sales manager
B.Sc. (Hons.) Chem. Eng. Area sales manager
E-mail: ahg@alsiano.com Tel. dir.: +45 8230 0026 Mobile: +45 2618 8545
E-mail: lan@alsiano.com Tel. dir.: +45 8230 0025 Mobile: +45 2270 1002
E-mail: ask@alsiano.com Tel. dir.: +45 8230 0049 Mobile: +45 2270 1015
Pharmaceuticals - cosmetics health & nutrition
On maternity leave from 1 July 2016
Pharmaceuticals - cosmetics health & nutrition
Pharmaceuticals - cosmetics health & nutrition
Key accounts
Quality
Logistics
Hedvig Åkesson
Susse Liff Hansen
Lene Baldasano del Valle
M.Sc. Agriculture Area sales manager
Quality manager
Logistics manager
E-mail: haa@alsiano.com Tel. dir.: +45 8230 0009 Mobile: +46 708 155 012
E-mail: slh@alsiano.com Tel. dir.: +45 8230 0017
E-mail: lb@alsiano.com Tel. dir.: +45 8230 0015
Sales support
Sales support Malene Rask Harder
Signe Mørck
Sales assistant
Sales assistant
E-mail: mrh@alsiano.com Tel. dir.: +45 8230 0007
E-mail: sm@alsiano.com Tel. dir.: +45 8230 0042
solutions based on innovation
New - calcium citrate for chewable tablets The new product from Jost Chemical Co. enables a non-gritty mouthfeel in chewable tablets formulated with calcium citrate One of the main stakes when developing an enriched chewable tablet is to avoid unpleasant taste and texture. For calcium enrichment, the challenge is high because of the significant amount of calcium salt that needs to be added to the formula to reach the 800 mg/day RDA. The use of a granular calcium salt facilitates the production of tablets by using the direct compression technology but it results in a very gritty mouthfeel. Granulated calcium citrate Jost already commercialises an ultrafine calcium citrate tetrahydrate. Its
particle size (6 micron median) makes it possible to elude the sensory detection in the mouth but it also means that this product is not usable in direct compression, limiting its use to sachets an d liquid applications. Jost has now developed a granulated calcium citrate. The granulation has been conducted on the basis of their ultrafine powder. The result is Calcium Citrate Granulated 80% (calcium content +/- 16.4%), which provides a compactable base and an enhanced mouthfeel.
Article 427
10