European Biotechnology News Special 11/2012 - BIO-Europe 2012

European Biotechnology News Science & Industry

November 2012

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01.11.2012 13:01:20 Uhr

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© Netherlands Embassy Berlin, Christian Richter

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8 February 2013, 9:30 a.m., Embassy of the Netherlands in Berlin, Germany Why attend?

The patent cliff and an increasingly payer-driven environment are problems for the life sciences industry. Specialised treatments have thus become a critical asset for pharma. Drug diagnostics combinations – so called companion diagnostics – offer companies the ability to develop targeted drugs with the potential for greater efficacy, accelerated regulatory approval and better reimbursement. Thus, developing treatments without suitable diagnostics has become an expensive form of Russian roulette. But, this joint process is complex. The challenges have created new forms of cooperation between pharma, biotechs and diagnostics service companies and resources needed to cope with giant amounts of data. The reward is huge: analysts forecast new billion dollar markets.

This BIOCOM Event offers a unique opportunity to gain insight into the converging strategies of pharma and diagnostics companies. Leading experts in the field of biomarkers, diagnostics, IT and drug development will share their knowledge on how to successfully develop and market new concepts.

Please register now at www.biocom.de/events/IP or send an email to events@biocom.de. Restricted Capacity!

Sponsors:

Supporting Partners:

Media Partner: European Biotechnology NET WORK

Organisation: BIOCOM AG | Lützowstraße 33–36 | 10785 Berlin www.biocom.de | events@biocom.de | Tel. +49 (0)30 264921-53 | Fax +49 (0)30 264921-66

30_EBSIN11_12_6th-IP.indd 6th-IP-Ad_210x275.indd 87 1

01.11.2012 13:01:44 12:06:08 Uhr

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Company

Drug

Indication

Bristol-Myers Squibb

BMS-094

Hepatitis C

Bristol-Myers Squibb (BMS) had to write-off US$1.7bn after a patient in a Phase III study became sick and died of heart failure. Other patients in the study had to be treated in hospital. Especially bad for BMS: only seven months earlier, it had paid US$2.5bn for Inhibitex â&#x20AC;&#x201C; and BMS094 was its biggest asset.

Pfizer, Johnson & Johnson

Bapineuzumab

Alzheimerâ&#x20AC;&#x2DC;s Disease

Pfizer and Johnson & Johnson terminated the development of bapineuzumab after the antibody targeting amyloid beta didnâ&#x20AC;&#x2DC;t show efficacy in two Phase III trials. Analysts had already given the drug little probability for success, as the companies had recruited Alzheimerâ&#x20AC;&#x2DC;s subjects in an advanced stage who had already sustained a lot of neural degradation.

Eli Lilly

LY2140023 Alimta Forteo Solanezumab Prasugrel

Schizophrenia Cancer Pain Alzheimerâ&#x20AC;&#x2DC;s Disease Myocardial infarction

Eli Lilly had a horrible summer. The company saw five late-stage trials fail between the end of July and early September: LY2140023 (schizophrenia), Alimta (cancer), Forteo (pain), solanezumab (Alzheimerâ&#x20AC;&#x2DC;s) and Prasugrel (myocardial infarction) all slipped-up within just two months of one another.

Roche

Dalcetrapib

Blood fat

When Roche stopped a Phase III study for its oft-praised blockbuster hopeful dalcetrapib, the disappointment couldnâ&#x20AC;&#x2DC;t have been worse.

The company had hoped for peak sales of US$10bn a year, but clinical trials involving 15,800 people couldnâ&#x20AC;&#x2DC;t prove that the drug has a protective effect on patients with stable coronary heart disease.

AstraZeneca

TC-5214

Depression

AstraZeneca had committed up to US$1.24bn to US biotech Targacept to acquire the rights for TC-5214, and conducted four late-stage trials that couldnâ&#x20AC;&#x2DC;t prove the treatment has a positive effect on patients with depression. However, AstraZeneca can take comfort from the fact that many competitors also shipwrecked with anti-depression drugs.

31_EBSIN11_12_Special_intro_pad.indd 31

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02.11.2012 11:32:00 Uhr

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31.10.2012 17:25:22 Uhr

ETB Award for the most innovative European biotech cooperation

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Impact of the ETB project

DTSH5N1 – A European success story “Development of a high throughput detection system for diagnostic purposes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­ %*5)#!#@JKL#7"6)&*7#)7#9%//#)7#".#-&7(6&'&*)"%#8%"9%%*#$&+$#)*-#/.9#,)"$.+%*&(#!2&)*# E*34%*5)#!#7"6)&*7;#M$%#."$%6#($)//%*+%#9)7#".#%7")8/&7$#)#'&*&)"46&7%-#)77)0#707"%'# 1.6#&*N2&"6.#(4/"46%#.1#E*34%*5)#!#@JKL#1.6#"$%#"%7"&*+# .1# ,$)6')(%4"&()/# ()*-&-)"%7# 9&"$#)*"&2&6)/#)("&2&"0#)+)&*7"#@JKL;#O."$#+.)/7#$)2%#74((%7714//0#8%%*#)"")&*%-#.*#)# /)8.6)".60#/%2%/; M$%#"%($*&P4%7#9$&($#7$.4/-#8%#),,/&%-#9%6%#8)7%-#.*#*4(/%&(#)(&-#"%($*./.+0#)*-# .*#(%//#(4/"46%#,6.(%-46%7#*%(%77)60#1.6#+6.9&*+#.1#E*34%*5)#2&647%7#)*-#1.6#-%2%/.,­ &*+#.1#'.*.(/.*)/#)*"&8.-&%7#80#@086&-.')#"%($*./.+0;

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EuroTransBio – international funding initiative ETB has funded 125 biotech projects worth more than D97$E+&$F$G$+".&/.+",$HIJ$KE=(C$999$!)!#*L+)$&',!"+5!-+&"($ !"#$ M$ /!',*$ )&LA!"+*(C$ &',!"+5*#$ +"$ (L!//$ )&"(&'-+!N$ 8th ETB call is open since October 4thC$DI9D$!"#$?+//$)/&(*$&"$ January 31stC$DI9HN$=;>$+($A'*(*"-$!-$>+&O=0'&A*$DI9DC$.+(+-$ us at booth n°98!!

www.eurotransbio.eu 33_EBSIN11_12_ETB.indd 1

31.10.2012 17:21:38 Uhr

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34_EBSIN_11_12_Special_Salans_tg.indd 34

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9edjWYj E=dbWZg\5hVaVch#Xdb

02.11.2012 11:33:05 Uhr

Hamburg and Schleswig-Holstein

Regional Host Sponsor of , BIO-Europe 2012 4, -1 12 r be m Nove Hamburg, Germany

Facing the Challenge 500 companies, research institutions, hospitals and universities in the Life Science Nord region create pioneering lead solutions for medical devices, biotechnology and the healthcare industry.

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35_EBSIN11_12_Norgenta.indd 1

31.10.2012 17:21:58 Uhr

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02.11.2012 17:17:39 Uhr

Meet us at 012 BIO-Europe 2 // Nov 12-14 Hamburg

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www.LifeScienceAustria.at

Ins_210x275_MESSEN2013_BioEurope2012.indd 1 37_EBSIN11_12_LISA.indd 1

10.07.12 14:39 31.10.2012 17:22:12 Uhr

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Experience Experience for forthe theFuture Future Biopharmaceutical Biopharmaceutical Biopharmaceutical Biopharmaceutical Development Development Development Development and and and and Manufacturing Manufacturing Manufacturing Manufacturing 33 recombinant recombinant 33 recombinant recombinant proteins proteins proteins proteins 33 antibody antibody 33 antibody antibody fragments fragments fragments fragments 33 vaccines vaccines 33 vaccines vaccines

Manufacturing Manufacturing Manufacturing Manufacturing Capabilities Capabilities Capabilities Capabilities 33 from from 33 from from strain strain strain strain development development development development to toAPI to API toAPI API production production production production 33 from 33 from from from lab lablab lab scale scale scale scale to to1500 to 1500 to1500 1500 LLlarge large LLlarge large scale scale scale scale manufacturing manufacturing manufacturing manufacturing 33 from from 33 from from clinical clinical clinical clinical trial trial trial trial supply supply supply supply to tocommercial to commercial tocommercial commercial production production production production

Partnering Partnering Partnering Partnering and and and and Licensing Licensing Licensing Licensing 33 33 33 global global 33 global global inin-inand inand and and out-licensing out-licensing out-licensing out-licensing of of of of biopharmaceutical biopharmaceutical biopharmaceutical biopharmaceutical projects projects projects projects

GMP GMP RichterRichterRichterRichterHELM HELM HELM HELM BioTec BioTec BioTec BioTec GmbH GmbH GmbH GmbH &&Co.KG Co.KG &&Co.KG Co.KG Suhrenkamp Suhrenkamp Suhrenkamp Suhrenkamp 59 5959 59 D-22335 D-22335 D-22335 D-22335 Hamburg Hamburg Hamburg Hamburg Germany Germany Germany Germany Tel.: Tel.: Tel.: Tel.: +49 +49 +49 +49 40 4040 55 40 5555 29 55 2929 08 29 0808 01 08 0101 01 Fax: Fax: Fax: Fax: +49 +49 +49 +49 40 4040 55 40 5555 29 55 2929 08 29 0808 88 08 8888 88 E-Mail: E-Mail: E-Mail: E-Mail: info@richter-helm.eu info@richter-helm.eu info@richter-helm.eu info@richter-helm.eu www.richter-helm.eu www.richter-helm.eu www.richter-helm.eu www.richter-helm.eu

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02.11.2012 11:36:23 Uhr

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01.11.2012 13:04:41 Uhr

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31.10.2012 17:41:19 Uhr

Untitl

C² && q KdajbZ && q '%&'

EurosBiotechsNews

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03/09/2012 31.10.2012 17:41:2412:43 Uhr