York Health Economics Consortium YHEC offers a range of services in different areas, as shown on the following slides
Reviewing Services • Systematic reviews, including network meta analyses (NMAs), to support health technology assessment (HTA) • Rapid reviews to provide accelerated evidence synthesis where there is no formal requirement for a systematic review • Scoping reviews to identify gaps in research and inform future research • Burden of illness reviews to understand the epidemiological, clinical, economic and humanistic burden of a disease area YHEC undertakes reviews for a variety of purposes YHEC has extensive experience of assessing the quality of both peer-reviewed publications and HTA submissions and we can appraise all aspects of systematic reviews and NMAs. YHEC also prepares manuscripts and coordinates the preparation of manuscripts for publication in peer reviewed journals
Information Services • Search strategy development – we can develop searches to capture your specifications • Reviews ranging from pragmatic to systematic • Critical appraisal of searches and reviews - we can advise on whether third party searches and reviews address a research question • Update searches and reviews • Managing search results - de-duplicating results, ensuring references are complete and developing display and output options. • Search filter development, validation and testing Information is at the heart of high quality healthcare, and information services are key to high quality research YHEC offers information services to support research in a range of formats
Health Economic Modelling Services Statisticalanalyses critiqueModelandvalidation Strategicadvice effectivenessCost-analyses analysesBudgetImpact Support submissionsHTAwith Bespoketraining modellingeconomicEarly adaptationsModel preparationManuscript
Outcomes Research Services StudiesHealthStateUtility Outcome Measurement SelectionProjects QualitativeResearch AssessmentOutcomeClinicalStrategy ValueHealthcareBasedEducation DevelopmentInstrument ExperimentsDiscreteChoice RegulatorySupport SupportPayer
NHS and Public Sector Consulting LocalbusinessNHScasemodels anddemandNHSsupplyanalysis Support applicationsgrantfor pathwayHealthandsocialcareanalysis Populationhealthdataanalysis Analysis of nationalprogrammespolicy modellingIncentive/tariff Advice parametersonforlocalstudies Workforceanalysis
Population Health and Digital Health Technologies analysisDistributionalcost-effectiveness(DCEA) Inequalitiesanalysis CPRD / studiesHES Cost of illness / burden of analysisillness trainingBespoke(HEandNHS) NICE submissionsMTEP DHT and evaluationsAI Advice FrameworkStandardsEvidenceNICEon modellingEarly
Statistics We can work with your individual patient level data (IPD) to optimise the economic model and product value proposition clinicalClienttrials propositionEconomicmodelProductvalueEconomicanalysisplan UoY data EconomichavensafeSAPFull GDPR compliance. Access on a named person basis. Data not located on YHEC servers. Prepared in consultation with client team to obtain agreement about what is needed from the analysis. Identification of relationships between variables Generation of prognostic risk equations (controlling for IPDEventSurvivalcofounders)analysisratecalculationbasedmeta-analysisUtilitydataanalysis
Statistical analysis 9
Other statistical services offered by YHEC • Perform regressions / meta-regressions on clinical trial data to derive inputs for economic models. • Survival analysis • Construct patient level simulation models in R • Event rate calculations Economic evaluations and modelling team • Perform regressions / meta-regressions on clinical trial data to derive inputs for economic models • Conduct propensity score matching between two populations for use in NHS and social care studies NHS and public sector team • Meta-analysis of multiple clinical trials means data can be pooled together to increase the strength of the analysis • Network meta-analyses (NMAs) for evaluating multiple treatments from multiple studies using both direct and indirect evidence • Population-adjusted indirect comparisons using techniques such as Matched adjusted-indirect treatment comparison (MAICs) Systematic reviews and information services team • Psychometrics – Instance factor analysis and Rasch analysis / Item-response theory • Conditional logit regressions • Mapping techniques for converting HRQoL measures • Utilities elicitation via time trade off and standard gamble, and strategic advice on patient reported outcome measures Outcomes research team Other non-team specific statistical tasks: • Write and critique statistical action plans (SAPs) • Extrapolate data beyond the final clinical trial data collection point • Create web-based user interfaces for statistical analyses outputs (R shiny) • Perform quality assurance and validity checks on models programmed in R • Control for confounding factors • Edit reports and manuscripts to explain complex statistical models in a way that is accessible to all audiences • Perform quality assurance and validity checks on survival analysis, utility analysis and indirect treatment comparisons
in-house medical writing team Medical Communications is the communication of scientific, medical, pharmaceutical and biotechnology information and data to various audiences. It involves: • Medical writing, the development and production of print or digital documents that deal specifically with medicine or health care. • Editing, ensuring content is consistent, grammatically correct and in compliance with relevant guidelines. • Payer/clinician engagement, conducting interviews to gain expertise or advice regarding disease management, HTA strategy, or other issues encountered in the health technology life cycle. Reviewing and servicesinformation Health economic modelling NHS and public consultancysector Outcomes research Medical writing services include: • HTAs • Manuscripts for peer review • Evidence dossiers • Global value dossiers (GVDs) • Executive slide decks • Conference abstracts/posters • Care pathway analysis • Early payer interviews YHEC’s medical writing team can also provide English language support and editing for all types of documents, including SLR reports, pragmatic reviews, economic reports, manuscripts and digital media.
YHEC’s
How to contact us York Health Economics Consortium Enterprise House, Innovation Way University of York, Heslington York, YO10 5NQ Phone : +44 (0)1904 323620 Email : https://www.linkedin.com/company/york-health-economics-consortium/https://twitter.com/YHEC1https://www.facebook.com/yorkhealtheconomicsconsortium/yhec@york.ac.uk