Complement component C5a, a type of anaphylatoxins, is one of the most potent effectors generated via cleavage of C5 molecule during complement activation. C5a binds two receptors, C5aR and C5L2. Most of the C5a functional effects occur by binding to C5aRs, a G-protein-coupled signaling receptor that has long been identified as an attractive drug target.
https://www.creative-biolabs.com/complement-therapeutics/complement-therapeutic-target-c5ar.htm
