Knock-out models can be roughly divided into conventional knock-out models and conditional knock-out models. Although conventional knock-outs offer a way to study gene function at a systematic level, many researchers choose a conditional knock-out approach instead due to their lethality risk and/or their limitations of analyzing a gene's role in the organogenesis of a particular tissue.https://www.creative-biolabs.com/drug-discovery/therapeutics/conditional-knock-out-models.htm