Lead optimization is a complex, iterative stage in drug discovery and development. It gives better quality of lead molecules. A confirmed lead is used as a starting point, and its toxicity, potency, stability, bioavailability and other pharmacokinetic parameters are studied in order to improve its target specificity, selectivity, and potency. The optimized molecules may subsequently be developed as drug(s).https://www.creative-biolabs.com/drug-discovery/therapeutics/lead-optimization-4.htm
