The major drawback of cell line derived xenografts (CDX) and patient derived xenografts (PDX) models is the lack of an immunocompetent host, while immunotherapy is based on manipulation of the immune system to fight cancer. Here, as a breakthrough platform, humanized mice models can generate functional human immune systems with expanding ability.
https://www.creative-biolabs.com/immuno-oncology/humanized-models.htm
