Primary amebic meningoencephalitis (PAM) is a rapidly progressive and potentially fatal infection caused by Naegleria fowleri. The free-living amoebae is world widely found in natural warm bodies of fresh water, such as lakes, rivers, and hot springs, and prefers temperatures between 25°C~40°C.https://www.creative-biolabs.com/complement-therapeutics/primary-amebic-meningoencephalitis.htm