CCMX Annual Activity Report 2009

ANNUAL ACTIVITY REPORT 2009

www.ccmx.ch Texts :

Elsbeth Heinzelmann, Bern&CCMX

Photos :

CCMX, EPFL, ETH Zurich, Empa, PSI, CSEM Layout & design :

www.antidote-design.ch Printing :

Images3 (www.images3.ch) Š CCMX, April 2010

ANNUAL ACTIVITY REPORT 2009

Message from the Chair

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2

Annual Activity Report 2009

Table of Contents

*O BEEJUJPO UP SFTFBSDI UIF FEVDBUJPO BOE PVUSFBDI QSPHSBNNF PG $$.9 JT GMPVSJTIJOH XJUI DPVSTFT FWFOUT BOE UFDIOPMPHZ BQFSJUJGT IFME JO 5IFTF FWFOUT IBWF QSPWFE UP CF BO FYDFMMFOU GPSVN GPS JOGPSNBM FYDIBOHFT CFUXFFO SFTFBSDIFST BOE GFFECBDL IBT CFFO WFSZ QPTJUJWF

How to be involved with CCMX ?

4

Learning with CCMX

6

Outreach and Networking activities

8

4JODFSFMZ

Professor Karen Scrivener Chair CCMX

The research we focus on

10

NanoXAS – a closer look into materials

12

A deep look into the nano cosmos – Time-Resolved Cathodoluminescence TRCL

14

Opening up new markets with ingenious neo-metallurgy

16

How to make use of modelling techniques for metallic systems

18

Flame Spray Deposition at low temperature – Surface treatment by coating and structuring

20

From ice cream to foams and micro-capsules

22

Our little helpers : Nanoparticles as a drug carrier – Functional particles in contact with biological fluids

24

New healing opportunities foreseen with innovative cell-sheet engineering – Medical device technology and innovation 26 How to create the perfect environment for single cells – Biosensing and diagnostic strategies

28

Materials for micro- and nanosystems : the Lab-on-a-chip – a reliable way to detect antibodies in a substance

30

2009 Data

32

2009 Peer reviewed publications

32

Projects funded in 2009

35

CCMX Team

36

Annual Activity Report 2009

3

Message from the Chair

*O $$.9 IBT BEWBODFE XFMM XJUI JUT DPSF NJTTJPO PG MJOLJOH NBUFSJBMT SFTFBSDI JO UIF &5) %PNBJO BOE $4&. UP JOEVTUSJBM OFFET 5IF GMBHTIJQ QSPKFDUT MBVODIFE JO IBWF OPX GJOJTIFE QSPEVDJOH NPSF UIBO OFX 1I%T JO .BUFSJBMT 4DJFODF BOE B IPTU PG QVCMJDBUJPOT 4FWFSBM IBWF MFE UP GPMMPX PO QSPKFDUT BU B &VSPQFBO MFWFM CSJOHJOH NPSF UIBO $)' NJMMJPO UP GVOE UIF 4XJTT SFTFBSDI HSPVQT 8F BSF OPX GPDVTJOH PO QSPKFDUT GVOEFE CZ QVCMJD QSJWBUF QBSUOFSTIJQT 111

XJUI GVOET GSPN JOEVTUSZ CFJOH EPVCMF NBUDIFE CZ GVOEJOH GSPN $$.9 5IJT IBT QSPNPUFE JOUFOTF EJTDVTTJPO CFUXFFO BDBEFNJD BOE JOEVTUSJBM SFTFBSDIFST UP JEFOUJGZ QSF DPNQFUJUJWF NBUFSJBMT SFTFBSDI OFFET PG UIF EJGGFSFOU JOEVTUSJBM TFDUPST "DSPTT UIF &36T BOE UIF BOBMZUJDBM QMBUGPSN TVDI QSPKFDUT BSF SVOOJOH PS TUBSUJOH XJUI DPNQBOJFT JOWPMWFE *U JT JOUFOEFE UIBU POF NPSF DBMM GPS TVDI 111 QSPKFDUT XJMM CF MBVODIFE CFGPSF UIF TVNNFS UBLJOH VT UP UIF FOE PG UIF DVSSFOU GVOEJOH QFSJPE

2

Annual Activity Report 2009

Table of Contents

*O BEEJUJPO UP SFTFBSDI UIF FEVDBUJPO BOE PVUSFBDI QSPHSBNNF PG $$.9 JT GMPVSJTIJOH XJUI DPVSTFT FWFOUT BOE UFDIOPMPHZ BQFSJUJGT IFME JO 5IFTF FWFOUT IBWF QSPWFE UP CF BO FYDFMMFOU GPSVN GPS JOGPSNBM FYDIBOHFT CFUXFFO SFTFBSDIFST BOE GFFECBDL IBT CFFO WFSZ QPTJUJWF

How to be involved with CCMX ?

4

Learning with CCMX

6

Outreach and Networking activities

8

4JODFSFMZ

Professor Karen Scrivener Chair CCMX

The research we focus on

10

NanoXAS – a closer look into materials

12

A deep look into the nano cosmos – Time-Resolved Cathodoluminescence TRCL

14

Opening up new markets with ingenious neo-metallurgy

16

How to make use of modelling techniques for metallic systems

18

Flame Spray Deposition at low temperature – Surface treatment by coating and structuring

20

From ice cream to foams and micro-capsules

22

Our little helpers : Nanoparticles as a drug carrier – Functional particles in contact with biological fluids

24

New healing opportunities foreseen with innovative cell-sheet engineering – Medical device technology and innovation 26 How to create the perfect environment for single cells – Biosensing and diagnostic strategies

28

Materials for micro- and nanosystems : the Lab-on-a-chip – a reliable way to detect antibodies in a substance

30

2009 Data

32

2009 Peer reviewed publications

32

Projects funded in 2009

35

CCMX Team

36

Annual Activity Report 2009

3

How to be involved with CCMX With the ambitious goal of being a link between academia and industry in the world of Materials Science in Switzerland, CCMX offers several entry points to its various programmes.

50 µm

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Research

4

Annual Activity Report 2009

Education & training

Outreach activities

$$.9 PGGFST TFWFSBM EJGGFSFOU UZQFT PG DPVSTFT 4VNNFS BOE XJOUFS TDIPPMT BSF HFBSFE NBJOMZ UPXBSET EPDUPSBM TUVEFOUT 5IF DPVSTFT BOE XPSLTIPQT BSF NPSF PSJFOUFE GPS FOHJOFFST BOE TDJFOUJTUT GSPN JOEVTUSZ XIP BSF MPPLJOH GPS PO HPJOH FEVDBUJPO BOE IBOET PO XPSLTIPQT XIFSF QBSUJDJQBOUT DBO WJTJU MBCT BOE BDUVBMMZ FYQFSJFODF TPNF PG UIF UIFPSZ UIBU JT UBVHIU 1MFBTF TFF QBHF GPS B TVNNBSZ PG UIF USBJOJOH QSPWJEFE JO

4FWFSBM FWFOUT BSF PSHBOJ[FE CZ $$.9 5IF NBJO BJNT PG UIFTF FWFOUT BSF LOPXMFEHF USBOTGFS BOE OFUXPSLJOH CZ BMMPXJOH QBSUJDJQBOUT UP NFFU BOE EJTDVTT NBUFSJBMT TDJFODF JO BMM JUT EJGGFSFOU BTQFDUT 5IF QSJODJQBM OFUXPSLJOH FWFOUT PSHBOJ[FE CZ $$.9 BSF DBMMFE Ä 5FDIOPMPHZ "QFSJUJGT Å 5IFTF BSF FOE PG BGUFSOPPO FBSMZ FWFOJOH FWFOUT UIBU DPOTJTU PG TDJFOUJGJD QSFTFOUBUJPOT PO B QBSUJDVMBS UPQJD GPMMPXFE CZ BO JOGPSNBM BQFSJUJG XIFSF

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Annual Activity Report 2009

5

How to be involved with CCMX With the ambitious goal of being a link between academia and industry in the world of Materials Science in Switzerland, CCMX offers several entry points to its various programmes.

50 µm

50 µm

QFPQMF DBO NFFU BOE UBML 1MFBTF TFF QBHF UP MFBSO BCPVU UIF PVUSFBDI BDUJWJUJFT JO

Research

4

Annual Activity Report 2009

Education & training

Outreach activities

$$.9 PGGFST TFWFSBM EJGGFSFOU UZQFT PG DPVSTFT 4VNNFS BOE XJOUFS TDIPPMT BSF HFBSFE NBJOMZ UPXBSET EPDUPSBM TUVEFOUT 5IF DPVSTFT BOE XPSLTIPQT BSF NPSF PSJFOUFE GPS FOHJOFFST BOE TDJFOUJTUT GSPN JOEVTUSZ XIP BSF MPPLJOH GPS PO HPJOH FEVDBUJPO BOE IBOET PO XPSLTIPQT XIFSF QBSUJDJQBOUT DBO WJTJU MBCT BOE BDUVBMMZ FYQFSJFODF TPNF PG UIF UIFPSZ UIBU JT UBVHIU 1MFBTF TFF QBHF GPS B TVNNBSZ PG UIF USBJOJOH QSPWJEFE JO

4FWFSBM FWFOUT BSF PSHBOJ[FE CZ $$.9 5IF NBJO BJNT PG UIFTF FWFOUT BSF LOPXMFEHF USBOTGFS BOE OFUXPSLJOH CZ BMMPXJOH QBSUJDJQBOUT UP NFFU BOE EJTDVTT NBUFSJBMT TDJFODF JO BMM JUT EJGGFSFOU BTQFDUT 5IF QSJODJQBM OFUXPSLJOH FWFOUT PSHBOJ[FE CZ $$.9 BSF DBMMFE Ä 5FDIOPMPHZ "QFSJUJGT Å 5IFTF BSF FOE PG BGUFSOPPO FBSMZ FWFOJOH FWFOUT UIBU DPOTJTU PG TDJFOUJGJD QSFTFOUBUJPOT PO B QBSUJDVMBS UPQJD GPMMPXFE CZ BO JOGPSNBM BQFSJUJG XIFSF

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Annual Activity Report 2009

5

Learning with CCMX 2009 was a fruitful year in terms of education. More than 200 persons participated in the different courses that were organized by CCMX. PhD students, engineers

“ If one must quickly sum up this experience I would say that it was a week one will not forget that brought a breath of fresh air with new insights and ideas for our research activities. � Nikola Castillo

and scientists from academia and from industry mixed together in very different settings ranging from the Swiss Alps to the benches of EPFL.

CCMX Winter School 5IF $$.9 8JOUFS 4DIPPM UPPL QMBDF GSPN UP +BOVBSZ JO -FT %JBCMFSFUT B GVO TLJ SFTPSU JO UIF 4XJTT "MQT 5IF 1I% TUVEFOUT XIP QBSUJDJQBUFE JO UIJT DPVSTF XFSF UISJMMFE XJUI UIFJS FYQFSJFODF "U GJSTU UIFZ QBSUMZ BENJUUFE UIBU UIFZ IBE NBJOMZ SFHJTUFSFE GPS UIF 8JOUFS 4DIPPM CFDBVTF PG UIF WFSZ BUUSBDUJWF NJYUVSF PG TOPX BOE TVSGBDF TDJFODF #VU UIFZ EJE BEE UIBU UIF JNQSFTTJWF MJOF VQ PG JOWJUFE TQFBLFST IBE CFFO UIF QSJODJQBM NPUJWB UJPO 5IF EBJMZ QSPHSBNNF XBT PSHBOJ[FE JO TVDI B XBZ UIBU UIF DPVSTFT DPWFSFE UIF NPSOJOHT BOE UIF FWFOJOHT MFBWJOH UIF BGUFSOPPOT GSFF GPS TLJJOH 5IF XIPMF JEFB PG UIFTF Ă„GSFFĂ… BGUFSOPPOT XBT UP BMMPX

6

Annual Activity Report 2009

“ The high impact surface science week was well balanced between scientific information and free time for the participants to interact with each other.

On the whole, it was an enriching week for all of us, both on the professional level and personal level. � Prabitha Urwyler

UIF TUVEFOUT UP OFUXPSL BOE HFU UP LOPX FBDI PUIFS 5IF TDJFOUJGJD QSPHSBNNF XBT TQMJU CFUXFFO GVOEBNFOUBMT PG TVSGBDF TDJFODF BOBMZUJDBM UPPMT GPS TVSGBDF DIBSBDUFSJ[BUJPO TVSGBDF NPEJGJDBUJPO NBUFSJBMT JO DPOUBDU XJUI CJPMPHJDBM FOWJSPONFOUT BOE TVSGBDFT JO FOFSHZ BOE DBUBMZTJT BQQMJDBUJPOT 4FWFSBM JOTUSVDUPST KPJOFE UIF DPVSTF GPS B DPVQMF PG EBZT BOE TIBSFE UIFJS LOPXM FEHF PO TVSGBDF TDJFODF GSPN UIFJS PXO QFSTQFDUJWF &BDI UIFNF PG JOUFSFTU XBT DPNQMFNFOUFE XJUI BO FYFSDJTF TFTTJPO JO UIF FWFOJOH DPOTJTUJOH PG QSFTFOUBUJPOT CZ B HSPVQ PG TUVEFOUT JO BDDPSEBODF XJUI QSF BTTJHOFE RVFTUJPOT

Some comments from the students : “ Teaching surface science to students with backgrounds as diverse as Materials Science, Physics, Chemistry and Biology, whom in addition work on topics that are fundamentally different, must have been a big challenge!

However this was a very positive feature which showed us how important and sometimes uneasy communication is between colleagues. �

2009 Programme of CCMX courses Date

Course

Title

25-30 January 2009

CCMX Winter School

Surface Science : Fundamentals, Properties & Selected Applications

01-02 April 2009

CCMX Continuing Education Course

Powder Charaterisation : from nanometers to millimeters and from theory to practice

29 June-03 July 2009

CCMX Summer School

Nano-Bio-Sensing

26-28 August 2009

CCMX Summer School

Modelling in Materials Science

09 September 2009

CCMX Workshop at the ESB2009

Design of Interfaces for Directing Biological Response

Annual Activity Report 2009

7

Learning with CCMX 2009 was a fruitful year in terms of education. More than 200 persons participated in the different courses that were organized by CCMX. PhD students, engineers

“ If one must quickly sum up this experience I would say that it was a week one will not forget that brought a breath of fresh air with new insights and ideas for our research activities. � Nikola Castillo

and scientists from academia and from industry mixed together in very different settings ranging from the Swiss Alps to the benches of EPFL.

CCMX Winter School 5IF $$.9 8JOUFS 4DIPPM UPPL QMBDF GSPN UP +BOVBSZ JO -FT %JBCMFSFUT B GVO TLJ SFTPSU JO UIF 4XJTT "MQT 5IF 1I% TUVEFOUT XIP QBSUJDJQBUFE JO UIJT DPVSTF XFSF UISJMMFE XJUI UIFJS FYQFSJFODF "U GJSTU UIFZ QBSUMZ BENJUUFE UIBU UIFZ IBE NBJOMZ SFHJTUFSFE GPS UIF 8JOUFS 4DIPPM CFDBVTF PG UIF WFSZ BUUSBDUJWF NJYUVSF PG TOPX BOE TVSGBDF TDJFODF #VU UIFZ EJE BEE UIBU UIF JNQSFTTJWF MJOF VQ PG JOWJUFE TQFBLFST IBE CFFO UIF QSJODJQBM NPUJWB UJPO 5IF EBJMZ QSPHSBNNF XBT PSHBOJ[FE JO TVDI B XBZ UIBU UIF DPVSTFT DPWFSFE UIF NPSOJOHT BOE UIF FWFOJOHT MFBWJOH UIF BGUFSOPPOT GSFF GPS TLJJOH 5IF XIPMF JEFB PG UIFTF Ă„GSFFĂ… BGUFSOPPOT XBT UP BMMPX

6

Annual Activity Report 2009

“ The high impact surface science week was well balanced between scientific information and free time for the participants to interact with each other.

On the whole, it was an enriching week for all of us, both on the professional level and personal level. � Prabitha Urwyler

UIF TUVEFOUT UP OFUXPSL BOE HFU UP LOPX FBDI PUIFS 5IF TDJFOUJGJD QSPHSBNNF XBT TQMJU CFUXFFO GVOEBNFOUBMT PG TVSGBDF TDJFODF BOBMZUJDBM UPPMT GPS TVSGBDF DIBSBDUFSJ[BUJPO TVSGBDF NPEJGJDBUJPO NBUFSJBMT JO DPOUBDU XJUI CJPMPHJDBM FOWJSPONFOUT BOE TVSGBDFT JO FOFSHZ BOE DBUBMZTJT BQQMJDBUJPOT 4FWFSBM JOTUSVDUPST KPJOFE UIF DPVSTF GPS B DPVQMF PG EBZT BOE TIBSFE UIFJS LOPXM FEHF PO TVSGBDF TDJFODF GSPN UIFJS PXO QFSTQFDUJWF &BDI UIFNF PG JOUFSFTU XBT DPNQMFNFOUFE XJUI BO FYFSDJTF TFTTJPO JO UIF FWFOJOH DPOTJTUJOH PG QSFTFOUBUJPOT CZ B HSPVQ PG TUVEFOUT JO BDDPSEBODF XJUI QSF BTTJHOFE RVFTUJPOT

Some comments from the students : “ Teaching surface science to students with backgrounds as diverse as Materials Science, Physics, Chemistry and Biology, whom in addition work on topics that are fundamentally different, must have been a big challenge!

However this was a very positive feature which showed us how important and sometimes uneasy communication is between colleagues. �

2009 Programme of CCMX courses Date

Course

Title

25-30 January 2009

CCMX Winter School

Surface Science : Fundamentals, Properties & Selected Applications

01-02 April 2009

CCMX Continuing Education Course

Powder Charaterisation : from nanometers to millimeters and from theory to practice

29 June-03 July 2009

CCMX Summer School

Nano-Bio-Sensing

26-28 August 2009

CCMX Summer School

Modelling in Materials Science

09 September 2009

CCMX Workshop at the ESB2009

Design of Interfaces for Directing Biological Response

Annual Activity Report 2009

7

Outreach and Networking activities Outreach and networking activities were numerous in 2009. Several “ Technology Aperitifs � were organized along side the regular Annual Meeting, a CCMX stand at NanoEurope and a conference on “ the state of the art and future of coating technologies �.

All these events were attended by more than 200 researchers, scientists, engineers and students.

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Materials Characterisation in Switzerland (CH)

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8

Annual Activity Report 2009

Materials Characterisation in Switzerland (CH)

Technology Aperitifs " TVSWFZ XBT DBSSJFE PVU BNPOH UIF QBSUJDJQBOUT PG UIF EJGGFSFOU 5FDIOPMPHZ "QFSJUJGT UP PCUBJO UIF TBUJTGBDUJPO SBUF 1MFBTF TFF CFMPX TPNF PG UIF DPNNFOUT Ă„.BOZ VTFGVM DPOUBDUT Ă… Ă„7FSZ HPPE JOGPSNBUJPO DPODFOUSBUFE

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2009 CCMX outreach and networking activities Date

Activity

26 March 2009

Technology Aperitif “Optical Effects at Surfaces�

22 April 2009

CCMX Annual Meeting

25 August 2009

Technology Aperitif “Materials for the Life Sciences�

01 October 2009

Conference “Stand und Zukunft des Beschichtungstechnologien�

28 October 2009

Science Day “Surface, Coatings & Particles Engineering�

25 November 2009

Technology Aperitif “Nanocoatings and Ultrathin Films�

25-26 November 2009

Stand at NanoEurope 2009

Annual Activity Report 2009

9

Outreach and Networking activities Outreach and networking activities were numerous in 2009. Several “ Technology Aperitifs � were organized along side the regular Annual Meeting, a CCMX stand at NanoEurope and a conference on “ the state of the art and future of coating technologies �.

All these events were attended by more than 200 researchers, scientists, engineers and students.

MaCH2 .B$) .BUFSJBMT $)BSBDUFSJTBUJPO JO 4XJU[FSMBOE $) JT UIF BOBMZUJDBM FRVJQ NFOU EBUBCBTF UIBU XBT DSFBUFE BOE MBVODIFE JO

Materials Characterisation in Switzerland (CH)

5IJT EBUBCBTF XBT TFU VQ GPMMPXJOH B SFRVFTU NBEF CZ UIF JOEVTUSZ *UT BDDFTT JT GSFF BOE BDDFTTJCMF UP BOZCPEZ XIP OFFET UP GJOE BOBMZUJDBM JOTUSVNFOUBUJPO BWBJMBCMF UP UIFN JO UIF &5) %PNBJO BOE $4&. &BDI JOTUSVNFOU JT MJTUFE XJUI JUT DPOUBDU QFSTPO BOE XJUI BQQMJDBUJPO FYBNQMFT JODMVEJOH QSPQFSUJFT UIBU DBO CF NFBTVSFE BOE NBUFSJBMT UIBU DBO CF BOBMZTFE .B$) JT HSPXJOH DPOTUBOUMZ BOE JT BWBJMBCMF BU XXX DDNY DI NBDI

8

Annual Activity Report 2009

Materials Characterisation in Switzerland (CH)

Technology Aperitifs " TVSWFZ XBT DBSSJFE PVU BNPOH UIF QBSUJDJQBOUT PG UIF EJGGFSFOU 5FDIOPMPHZ "QFSJUJGT UP PCUBJO UIF TBUJTGBDUJPO SBUF 1MFBTF TFF CFMPX TPNF PG UIF DPNNFOUT Ă„.BOZ VTFGVM DPOUBDUT Ă… Ă„7FSZ HPPE JOGPSNBUJPO DPODFOUSBUFE

UP HFU BO PWFSWJFX Ă… Ă„5IF QSFTFOUBUJPOT XFSF TIPSU BOE SFMFWBOU BOE TUJNVMBUJOH Ă… Ă„5IF TIPSU UJNF TFNJOBST BSF PG JOUFSFTU UP NF BT DPOTVMUBOU * DBO TFF BOE TQFBL UP SFQSFTFOUBUJWFT PG JOEVTUSZ BOE BDBEFNJB * BN JOGPSNFE RVJDLMZ BOE UIF MBUF BGUFS OPPO PGGFST UIF PQQPSUVOJUZ OPU UP XBTUF UP NVDI UJNF Ă…

2009 CCMX outreach and networking activities Date

Activity

26 March 2009

Technology Aperitif “Optical Effects at Surfaces�

22 April 2009

CCMX Annual Meeting

25 August 2009

Technology Aperitif “Materials for the Life Sciences�

01 October 2009

Conference “Stand und Zukunft des Beschichtungstechnologien�

28 October 2009

Science Day “Surface, Coatings & Particles Engineering�

25 November 2009

Technology Aperitif “Nanocoatings and Ultrathin Films�

25-26 November 2009

Stand at NanoEurope 2009

Annual Activity Report 2009

9

Photo : PSI

The research we focus on Fostering public-private partnerships 5IF 3FTFBSDI 5JDLFU 1SPHSBNNF JT EFTJHOFE UP GPTUFS QVCMJD QSJWBUF QBSUOFSTIJQT JO NBUFSJBMT TDJFODF JO PSEFS UP FOTVSF UIF MPOHFWJUZ PG UIF JOUFSBDUJPOT CFUXFFO JOEVTUSZ BOE UIF $$.9 JOTUJUVUJPOT *OTUFBE PG FOHBHJOH JO SFTFBSDI PO B QSPKFDU CZ QSPKFDU CBTJT BT JU IBT CFFO EPOF JO UIF QBTU JOEVTUSJBM QBSUOFST DPMMBCPSBUF XJUI BDB EFNJD HSPVQT JO B DPOTPSUJVN GPDVTJOH PO B TFMFDUFE Ă„ 5IFNBUJD 3FTFBSDI "SFB Ă… 5IF DSFBUJPO PG NVMUJMBUFSBM QBSUOFSTIJQT GPS NFEJVN UFSN QSF DPNQFUJUJWF SFTFBSDI JT NVUVBMMZ CFOFGJDJBM BOE JT B HPPE BQQSPBDI UP CSJEHF UIF GVOEJOH HBQ CFUXFFO UIF GVOEBNFOUBM SFTFBSDI TVQQPSUFE CZ 4/4' BOE UIF BQQMJFE Ă„ DMPTF UP NBSLFU Ă… QSPKFDUT TVQQPSUFE CZ $5*

Companies involved in 2009 in projects (21) Alphabetic order

• ABB Turbo Systems • Alstom • Alcan • Asulab • Attolight • AO Foundation • Arrayon Biotechnology SA • Ayanda Biosystems SA • Biotronik AG • ION-TOF Technologies • Kugler Bimetal • Lovalite • Lyncee Tec • Metalor • Novelis • OPEA • Rolex • Sanofi Pasteur • SurfaceSolutionsS AG • swissnuclear • YXLON International X-Ray GmbH

What is pre-competitive research ?

1SF DPNQFUJUJWF SFTFBSDI JT B NJEEMF HSPVOE PG GPDVTFE DVUUJOH FEHF SFTFBSDI UIBU MJFT CFUXFFO GVOEBNFOUBM CBTJD SFTFBSDI DPOEVDUFE NBJOMZ JO VOJWFSTJUJFT &5) EPNBJO BOE QSPQSJFUBSZ SFTFBSDI QFSGPS NFE JO DPSQPSBUF MBCPSBUPSJFT

Members from industry identify priority research topics with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

10

Annual Activity Report 2009

Thematic research areas in 2009

Why should industry participate ?

• • • • • • •

• • • • • • •

Neo-metallurgy : new alloys, new processes and new investigation techniques Multi-scale, multi-phenomena modelling of metallic systems Surface modification by coating and structuring Functional foams Functional particles in contact with biological fluids Medical device technology and innovation Biosensing and diagnostic strategies

Keeping materials characterisation in the loop *O BEEJUJPO UP UIJT SFTFBSDI QSPHSBNNF $$.9ŠT "OBMZUJDBM 1MBUGPSN CSJOHT UPHFUIFS FYQFSUJTF JO UIF EFWFMPQNFOU PG BOBMZUJDBM NFUIPET BOE CSPBE BOBMZUJDBM SFTPVSDFT GSPN EJGGFSFOU JOTUJUVUJPOT XJUIJO UIF &5) EPNBJO JOEVTUSJBM QBSUOFST BOE PUIFS VOJWFSTJUJFT 0O POF IBOE UIF BOBMZUJDBM QMBUGPSN GVOET QSPKFDUT BJNFE BU UIF

EFWFMPQNFOU PG OFX BOBMZUJDBM UPPMT NFUIPET PS JOTUSVNFOUBUJPO GPS UIF BOBMZTJT PG QIZTJDBM CJPMPHJDBM PS DIFNJDBM QSPQFSUJFT PO UIF TDBMF CFMPX ON 0O UIF PUIFS IBOE UIF QSPKFDUT GVOEFE DPODFSO UIF FY QMPJUBUJPO PG FYJTUJOH BOBMZUJDBM UFDIOJRVFT GPS OBOPTDBMF BOBMZTJT JO OFX GJFMET PG BQQMJDBUJPO $P GVOEJOH GSPN JOEVTUSJBM QBSUOFST BOE PS PUIFS JOTUJUVUJPOT JT B LFZ BTQFDU PG UIFTF QSPKFDUT

Increased expertise in topics relevant to industry Access to hiring well-trained scientists Access to new knowledge, data and tools Access to multiple Swiss research institutions and equipment Directing research on industry’s medium and long term needs Option to negotiate IP Rights Vote on allowing other companies to join

Research expenditures by research area (%) Neo-metallurgy Modelling of metallic systems Surface modification by coating and structuring Functional foams Functional particles in contact with biological fluids Medical device technology and innovation Biosensing and diagnostic strategies Analytical platform

11 % 15 % 16 % 5% 9% 9% 17 % 18 %

Annual Activity Report 2009

11

Photo : PSI

The research we focus on Fostering public-private partnerships 5IF 3FTFBSDI 5JDLFU 1SPHSBNNF JT EFTJHOFE UP GPTUFS QVCMJD QSJWBUF QBSUOFSTIJQT JO NBUFSJBMT TDJFODF JO PSEFS UP FOTVSF UIF MPOHFWJUZ PG UIF JOUFSBDUJPOT CFUXFFO JOEVTUSZ BOE UIF $$.9 JOTUJUVUJPOT *OTUFBE PG FOHBHJOH JO SFTFBSDI PO B QSPKFDU CZ QSPKFDU CBTJT BT JU IBT CFFO EPOF JO UIF QBTU JOEVTUSJBM QBSUOFST DPMMBCPSBUF XJUI BDB EFNJD HSPVQT JO B DPOTPSUJVN GPDVTJOH PO B TFMFDUFE Ă„ 5IFNBUJD 3FTFBSDI "SFB Ă… 5IF DSFBUJPO PG NVMUJMBUFSBM QBSUOFSTIJQT GPS NFEJVN UFSN QSF DPNQFUJUJWF SFTFBSDI JT NVUVBMMZ CFOFGJDJBM BOE JT B HPPE BQQSPBDI UP CSJEHF UIF GVOEJOH HBQ CFUXFFO UIF GVOEBNFOUBM SFTFBSDI TVQQPSUFE CZ 4/4' BOE UIF BQQMJFE Ă„ DMPTF UP NBSLFU Ă… QSPKFDUT TVQQPSUFE CZ $5*

Companies involved in 2009 in projects (21) Alphabetic order

• ABB Turbo Systems • Alstom • Alcan • Asulab • Attolight • AO Foundation • Arrayon Biotechnology SA • Ayanda Biosystems SA • Biotronik AG • ION-TOF Technologies • Kugler Bimetal • Lovalite • Lyncee Tec • Metalor • Novelis • OPEA • Rolex • Sanofi Pasteur • SurfaceSolutionsS AG • swissnuclear • YXLON International X-Ray GmbH

What is pre-competitive research ?

1SF DPNQFUJUJWF SFTFBSDI JT B NJEEMF HSPVOE PG GPDVTFE DVUUJOH FEHF SFTFBSDI UIBU MJFT CFUXFFO GVOEBNFOUBM CBTJD SFTFBSDI DPOEVDUFE NBJOMZ JO VOJWFSTJUJFT &5) EPNBJO BOE QSPQSJFUBSZ SFTFBSDI QFSGPS NFE JO DPSQPSBUF MBCPSBUPSJFT

Members from industry identify priority research topics with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

10

Annual Activity Report 2009

Thematic research areas in 2009

Why should industry participate ?

• • • • • • •

• • • • • • •

Neo-metallurgy : new alloys, new processes and new investigation techniques Multi-scale, multi-phenomena modelling of metallic systems Surface modification by coating and structuring Functional foams Functional particles in contact with biological fluids Medical device technology and innovation Biosensing and diagnostic strategies

Keeping materials characterisation in the loop *O BEEJUJPO UP UIJT SFTFBSDI QSPHSBNNF $$.9ŠT "OBMZUJDBM 1MBUGPSN CSJOHT UPHFUIFS FYQFSUJTF JO UIF EFWFMPQNFOU PG BOBMZUJDBM NFUIPET BOE CSPBE BOBMZUJDBM SFTPVSDFT GSPN EJGGFSFOU JOTUJUVUJPOT XJUIJO UIF &5) EPNBJO JOEVTUSJBM QBSUOFST BOE PUIFS VOJWFSTJUJFT 0O POF IBOE UIF BOBMZUJDBM QMBUGPSN GVOET QSPKFDUT BJNFE BU UIF

EFWFMPQNFOU PG OFX BOBMZUJDBM UPPMT NFUIPET PS JOTUSVNFOUBUJPO GPS UIF BOBMZTJT PG QIZTJDBM CJPMPHJDBM PS DIFNJDBM QSPQFSUJFT PO UIF TDBMF CFMPX ON 0O UIF PUIFS IBOE UIF QSPKFDUT GVOEFE DPODFSO UIF FY QMPJUBUJPO PG FYJTUJOH BOBMZUJDBM UFDIOJRVFT GPS OBOPTDBMF BOBMZTJT JO OFX GJFMET PG BQQMJDBUJPO $P GVOEJOH GSPN JOEVTUSJBM QBSUOFST BOE PS PUIFS JOTUJUVUJPOT JT B LFZ BTQFDU PG UIFTF QSPKFDUT

Increased expertise in topics relevant to industry Access to hiring well-trained scientists Access to new knowledge, data and tools Access to multiple Swiss research institutions and equipment Directing research on industry’s medium and long term needs Option to negotiate IP Rights Vote on allowing other companies to join

Research expenditures by research area (%) Neo-metallurgy Modelling of metallic systems Surface modification by coating and structuring Functional foams Functional particles in contact with biological fluids Medical device technology and innovation Biosensing and diagnostic strategies Analytical platform

11 % 15 % 16 % 5% 9% 9% 17 % 18 %

Annual Activity Report 2009

11

NanoXAS : a closer look into materials NMMC

The Paul Scherrer Institut (PSI) is not only the biggest research laboratory in Switzerland, but it has also been home to a world-wide unique experiment aimed at revealing some of the ultimate mysteries in materials science since November 2009. Up until recently, the Scanning Probe Microscopes (SPM) were available to assist in resolving surface topography, electronic and mechanical properties down to the atomic scale.

Although these are powerful tools in areas as diverse as semiconductors, magnetic memory, polymers, and surface coating, they do not provide any chemical information. On the other hand, there were also Scanning

Transmission X-ray Microscopes (STXM) measuring the x-rays transmitted through a thin sample and thus providing chemical information for such materials. Unfortunately, the spatial resolution of STXM analysis is limited to about 20 nm due to the difficulty of focussing x-rays to finer spots.

4DJFOUJTUT GSPN 14* BOE &NQB UIF 4XJTT 'FEFSBM -BCPSBUPSZ GPS .BUFSJBMT 5FTUJOH BOE 3FTFBSDI IBWF DPNCJOFE UIFTF UXP UFDIOJRVFT JO B GVOEBNFOUBMMZ OFX JOTUSVNFOU *O UIFJS OFX /BOP9"4 JOTUSVNFOU MPDBUFE BU 14* JO 7JMMJHFO UIFZ KPJO UIFJS FYQFSJFODF PG TZODISPUSPO SBEJBUJPO TQFDUSPTDPQZ BOE TDBOOJOH QSPCF NJDSPTDPQZ 5IF /BOP9"4 JOTUSVNFOU VTFT Y SBZT QSPEVDFE CZ UIF 4XJTT -JHIU 4PVSDF 4-4 5IFTF Y SBZT BSF NBOZ PSEFST PG NBHOJUVEF NPSF JOUFOTF BOE CFUUFS GPDVTFE UIBO Y SBZT GSPN B MBCPSBUPSZ TPVSDF *O BEEJUJPO UIFJS FOFSHZ DBO CF BEKVTUFE UP NBUDI UIF BCTPSQUJPO PG EJGGFSFOU DIFNJDBM FMFNFOUT FBDI PG XIJDI IBT B VOJRVF GJOHFSQSJOU JO UIF Y SBZ BCTPSQUJPO " DIBOHF JO QPMBSJ[BUJPO FWFO NBLFT JU QPTTJCMF UP TUVEZ UIF PSJFOUBUJPO PG NBHOFUJD GJFMET JO NBUFSJBMT *O UIF OFX JOTUSVNFOU Y SBZT PG BEKVTUBCMF FOFSHZ BOE QPMBSJ[BUJPO JMMVNJOBUF UIF TBNQMF 5IF UJQ PG B TQFDJBMMZ EFTJHOFE TDBOOJOH QSPCF NJDSPTDPQF JT VTFE UP EFUFDU QIPUPFMFDUSPOT XIJDI BSF QSPEVDFE VQPO BCTPSQUJPO PG UIF Y SBZT CZ TFMFDUFE DIFNJDBM FMFNFOUT 5IJT OPU POMZ HSFBUMZ FOIBODFT UIF TQBUJBM SFTPMVUJPO CVU UIF DPNCJOBUJPO PG 41. BOE Y SBZ UFDIOJRVFT BMTP QSPWJEFT OFX DPOUSBTU NPEFT BOE UIVT BMMPXT B DMPTFS MPPL JOUP NBUFSJBMT

12

Annual Activity Report 2009

"T POF PG JUT GJSTU BQQMJDBUJPOT UIF /BOP9"4 JOTUSVNFOU JT QSFTFOUMZ CFJOH VTFE UP TIFE MJHIU POUP UIF GVODUJPO PG OPWFM FMFDUSPOJD EFWJDFT BOE NBHOFUJD TUPSBHF NFEJB Ă„ *O UIF DBTF PG NBOZ TFNJDPOEVDUPS PS NBHOFUJD NBUFSJBMT GPS TUPSBHF NFEJB XF EP OPU LOPX FYBDUMZ IPX UIFZ XPSL BT UIF SFMFWBOU TUSVDUVSFT BSF UPP TNBMM UP CF MPPLFE BU XJUI NFUIPET BWBJMBCMF VQ UP OPX Ă… TBZT %S +PFSH 3BBCF B TDJFOUJTU JO DIBSHF PG UIF QSPKFDU Ă„#Z VTJOH UIF /BOP9"4 JOTUSVNFOU XF DBO PCTFSWF UIF PSJFOUBUJPO PG OBOP TJ[FE SFHJPOT JO NBUFSJBMT GPS DPNQVUFS IBSE EJTLT PS UIF EJTUSJCVUJPO PG EPQJOH BUPNT JO OPWFM TFNJDPOEVDUPST Ă… 4NBMM RVBOUJUJFT PG EPQJOH BUPNT BSF JOUSPEVDFE JOUP TFNJDPOEVDUPS NBUFSJBMT UP NPEJGZ UIFJS FMFDUSJDBM DPOEVDUJWJUZ 5IF CPVOEBSZ CFUXFFO SFHJPOT PG EJGGFSFOU EPQJOH BSF XIBU NBLFT FMFNFOUT MJLF B USBOTJTUPS

XPSL "MUIPVHI UIFZ BSF WFSZ TNBMM UIFZ BSF XIBU OFFET UP CF TUVEJFE 8JUI TVDI JOTJHIU TDJFOUJTUT DBO OPX VOEFSTUBOE UIF EFUBJMT PG QSFTFOU EBZ NBUFSJBMT BOE VTF UIJT VOEFSTUBOEJOH UP PQUJNJ[F GVUVSF NBUFSJBMT GPS FMFDUSPOJD DPNQPOFOUT PS NBHOFUJD TUPSBHF NFEJB Ä 5IFSF JT B IFBWZ EFNBOE GPS JOWFTUJHBUJPOT XJUI UIF /BOP9"4 GSPN DPNQBOJFT BOE SFTFBSDI JOTUJUVUFT GSPN BMM PWFS UIF XPSME Å DPNNFOUT %S *SJT 4DINJE QIZTJDJTU BU 14* BOE SFTQPOTJCMF GPS UIF QSFDJPVT JOTUSVNFOU 4VDI EFNBOE JT B HPPE TJHO PG UIJT VOJRVF NJDSPTDPQFŠT TVDDFTT *U XBT DSFBUFE UIBOLT UP B DPPQFSBUJPO CFUXFFO 14* BOE &NQB XJUI UIF 6OJWFSTJUZ PG #BTFM BOE (FSNBO JOTUJUVUJPOT BOE QBSUJBMMZ GVOEFE CZ $$.9 *U XJMM QSPWJEF SFTFBSDIFST GSPN UIFTF JOTUJUVUJPOT BOE NBOZ PUIFS QBSUOFST XJUI B CFUUFS JOTJHIU JOUP NBUFSJBMT

Annual Activity Report 2009

13

NanoXAS : a closer look into materials NMMC

The Paul Scherrer Institut (PSI) is not only the biggest research laboratory in Switzerland, but it has also been home to a world-wide unique experiment aimed at revealing some of the ultimate mysteries in materials science since November 2009. Up until recently, the Scanning Probe Microscopes (SPM) were available to assist in resolving surface topography, electronic and mechanical properties down to the atomic scale.

Although these are powerful tools in areas as diverse as semiconductors, magnetic memory, polymers, and surface coating, they do not provide any chemical information. On the other hand, there were also Scanning

Transmission X-ray Microscopes (STXM) measuring the x-rays transmitted through a thin sample and thus providing chemical information for such materials. Unfortunately, the spatial resolution of STXM analysis is limited to about 20 nm due to the difficulty of focussing x-rays to finer spots.

4DJFOUJTUT GSPN 14* BOE &NQB UIF 4XJTT 'FEFSBM -BCPSBUPSZ GPS .BUFSJBMT 5FTUJOH BOE 3FTFBSDI IBWF DPNCJOFE UIFTF UXP UFDIOJRVFT JO B GVOEBNFOUBMMZ OFX JOTUSVNFOU *O UIFJS OFX /BOP9"4 JOTUSVNFOU MPDBUFE BU 14* JO 7JMMJHFO UIFZ KPJO UIFJS FYQFSJFODF PG TZODISPUSPO SBEJBUJPO TQFDUSPTDPQZ BOE TDBOOJOH QSPCF NJDSPTDPQZ 5IF /BOP9"4 JOTUSVNFOU VTFT Y SBZT QSPEVDFE CZ UIF 4XJTT -JHIU 4PVSDF 4-4 5IFTF Y SBZT BSF NBOZ PSEFST PG NBHOJUVEF NPSF JOUFOTF BOE CFUUFS GPDVTFE UIBO Y SBZT GSPN B MBCPSBUPSZ TPVSDF *O BEEJUJPO UIFJS FOFSHZ DBO CF BEKVTUFE UP NBUDI UIF BCTPSQUJPO PG EJGGFSFOU DIFNJDBM FMFNFOUT FBDI PG XIJDI IBT B VOJRVF GJOHFSQSJOU JO UIF Y SBZ BCTPSQUJPO " DIBOHF JO QPMBSJ[BUJPO FWFO NBLFT JU QPTTJCMF UP TUVEZ UIF PSJFOUBUJPO PG NBHOFUJD GJFMET JO NBUFSJBMT *O UIF OFX JOTUSVNFOU Y SBZT PG BEKVTUBCMF FOFSHZ BOE QPMBSJ[BUJPO JMMVNJOBUF UIF TBNQMF 5IF UJQ PG B TQFDJBMMZ EFTJHOFE TDBOOJOH QSPCF NJDSPTDPQF JT VTFE UP EFUFDU QIPUPFMFDUSPOT XIJDI BSF QSPEVDFE VQPO BCTPSQUJPO PG UIF Y SBZT CZ TFMFDUFE DIFNJDBM FMFNFOUT 5IJT OPU POMZ HSFBUMZ FOIBODFT UIF TQBUJBM SFTPMVUJPO CVU UIF DPNCJOBUJPO PG 41. BOE Y SBZ UFDIOJRVFT BMTP QSPWJEFT OFX DPOUSBTU NPEFT BOE UIVT BMMPXT B DMPTFS MPPL JOUP NBUFSJBMT

12

Annual Activity Report 2009

"T POF PG JUT GJSTU BQQMJDBUJPOT UIF /BOP9"4 JOTUSVNFOU JT QSFTFOUMZ CFJOH VTFE UP TIFE MJHIU POUP UIF GVODUJPO PG OPWFM FMFDUSPOJD EFWJDFT BOE NBHOFUJD TUPSBHF NFEJB Ă„ *O UIF DBTF PG NBOZ TFNJDPOEVDUPS PS NBHOFUJD NBUFSJBMT GPS TUPSBHF NFEJB XF EP OPU LOPX FYBDUMZ IPX UIFZ XPSL BT UIF SFMFWBOU TUSVDUVSFT BSF UPP TNBMM UP CF MPPLFE BU XJUI NFUIPET BWBJMBCMF VQ UP OPX Ă… TBZT %S +PFSH 3BBCF B TDJFOUJTU JO DIBSHF PG UIF QSPKFDU Ă„#Z VTJOH UIF /BOP9"4 JOTUSVNFOU XF DBO PCTFSWF UIF PSJFOUBUJPO PG OBOP TJ[FE SFHJPOT JO NBUFSJBMT GPS DPNQVUFS IBSE EJTLT PS UIF EJTUSJCVUJPO PG EPQJOH BUPNT JO OPWFM TFNJDPOEVDUPST Ă… 4NBMM RVBOUJUJFT PG EPQJOH BUPNT BSF JOUSPEVDFE JOUP TFNJDPOEVDUPS NBUFSJBMT UP NPEJGZ UIFJS FMFDUSJDBM DPOEVDUJWJUZ 5IF CPVOEBSZ CFUXFFO SFHJPOT PG EJGGFSFOU EPQJOH BSF XIBU NBLFT FMFNFOUT MJLF B USBOTJTUPS

XPSL "MUIPVHI UIFZ BSF WFSZ TNBMM UIFZ BSF XIBU OFFET UP CF TUVEJFE 8JUI TVDI JOTJHIU TDJFOUJTUT DBO OPX VOEFSTUBOE UIF EFUBJMT PG QSFTFOU EBZ NBUFSJBMT BOE VTF UIJT VOEFSTUBOEJOH UP PQUJNJ[F GVUVSF NBUFSJBMT GPS FMFDUSPOJD DPNQPOFOUT PS NBHOFUJD TUPSBHF NFEJB Ä 5IFSF JT B IFBWZ EFNBOE GPS JOWFTUJHBUJPOT XJUI UIF /BOP9"4 GSPN DPNQBOJFT BOE SFTFBSDI JOTUJUVUFT GSPN BMM PWFS UIF XPSME Å DPNNFOUT %S *SJT 4DINJE QIZTJDJTU BU 14* BOE SFTQPOTJCMF GPS UIF QSFDJPVT JOTUSVNFOU 4VDI EFNBOE JT B HPPE TJHO PG UIJT VOJRVF NJDSPTDPQFŠT TVDDFTT *U XBT DSFBUFE UIBOLT UP B DPPQFSBUJPO CFUXFFO 14* BOE &NQB XJUI UIF 6OJWFSTJUZ PG #BTFM BOE (FSNBO JOTUJUVUJPOT BOE QBSUJBMMZ GVOEFE CZ $$.9 *U XJMM QSPWJEF SFTFBSDIFST GSPN UIFTF JOTUJUVUJPOT BOE NBOZ PUIFS QBSUOFST XJUI B CFUUFS JOTJHIU JOUP NBUFSJBMT

Annual Activity Report 2009

13

A deep look into the nano cosmos : Time-Resolved Cathodoluminescence TRCL NMMC

Time-resolved cathodoluminescence (TRCL) is the ideal tool to measure dynamics at the nanoscale. “With this spectroscopy technique you select an excitation point, send an electron pulse, collect the outgoing light and resolve it spectrally and temporally”, explains Dr. Samuel Sonderegger.

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

14

Annual Activity Report 2009

UVCF DSFBUJOH B WBDVVN BMPOH UIF PQUJDBM BYJT BOE LFFQJOH UIF FMFDUSPNBHOFUJD DPJMT PVUTJEF 5IF DPJMT MPDBUFE JO UIF VQQFS QBSU PG UIF PCKFDUJWF TFSWF BT TUJHNBUPS BOE EFGMFDUPS UP TIBQF UIF FMFDUSPO CFBN UIPTF XIJDI BSF JO UIF MPXFS QBSU PG UIF PCKFDUJWF BDU BT TDBOOJOH DPJMT 5IF NBJO DIBNCFS NBEF PG NBTTJWF JSPO QSPUFDUT UIF TBNQMF TUBHF BOE UIF CFBN GSPN NF DIBOJDBM WJCSBUJPOT BOE FMFDUSPNBHOFUJD JOUFSGFSFODFT 5IF EFUFDUJPO JT DBSSJFE PVU PO POF IBOE CZ B TFDPOEBSZ FMFDUSPO EFUFDUPS MPDBUFE PO POF PG UIF TJEF XBMMT PG UIF DIBNCFS BOE PO UIF PUIFS IBOE CZ B TJNQMF TPMJE TUBUF EFUFDUPS MPDBUFE JOTJEF UIF HBQ PG UIF PCKFDUJWF MFOT XPSLJOH XJUI CBDLTDBUUFSFE FMFDUSPOT %VSJOH UIF XIPMF QSPKFDU UIFSF XBT B DMPTF DPMMBCPSBUJPO XJUI UIF JOEVTUSJBM QBSUOFS "UUPMJHIU T DSFX QSPEVDFE UIF GJCFS CBTFE QPJOUFE QIPUP DBUIPEF GPS UIF HFOFSBUJPO PG QIPUPFMFDUSPOT BOE QSPWJEFE UIF 67 MBTFS OFDFTTBSZ UP UFTU UIF EFWJDF "U UIF FOE PG %S +FBO %BOJFM (BOJ SF HJWFT B QPTJUJWF TVNNBSZ Ä"DUVBMMZ XF IBE QMBOOFE UP SFBDI ON VTJOH FMFDUSPTUBUJD MFOTFTÅ IF DPNNFOUT Ä#VU EVSJOH UIF EFTJHO QIBTF JU UVSOFE PVU UIBU NBHOFUJD MFOTFT XPVME CF NPSF TVJUBCMF UIBO FMFDUSPTUBUJD POFT 8F PQUJNJ[FE UIFN BOE UIJT ZJFMEFE B ON SFTPMVUJPO 5IFO UIF FMFDUSPO PQUJDT XFSF CVJMU BOE B TQBUJBM SFTPMVUJPO PG ON XBT BDIJFWFE Å 'PS QSPEVDUJPO DPTU SFBTPOT UIF SFTFBSDIFST IBE QMBOOFE UP XPSL BU B GJYFE BDDFMFSBUJPO WPMUBHF PG L7 *O UIF

DPVSTF PG UIFJS TUVEJFT UIFZ SFBMJ[FE UIBU XJUI NBHOFUJD MFOTFT UIFZ DPVME HFU B UVOFBCMF BDDFMFSBUJPO WPMUBHF CFUXFFO L7 5IBU XBT HPPE OFXT GPS +FBO %BOJFM (BOJ SF Ä-PX BDDFMFSBUJPO WPMUBHFT BSF DSVDJBM GPS BQQMJDBUJPOT PO QPMZNFST BOE

CJPMPHJDBM TBNQMFT Å 5IF SFTVMUT PG UIF $$.9 QSPKFDU PQFO VQ OFX IPSJ[POT GPS UIF TFNJDPOEVDUPS JOEVTUSZ BOE "UUPMJHIU JT HPJOH UP MBVODI UIF QSPEVDU PO UIF NBSLFU $PODSFUF BQQMJDBUJPOT BSF GPS JOTUBODF UIF EFGFDU BOBMZTJT JO (BMMJVN OJUSJEF -PDBM

MJGFUJNF NFBTVSFNFOUT CSJOH UIF UFNQPSBM EJNFOTJPO UP EFGFDU BOBMZTJT QSPWJEJOH GVSUIFS JOTJHIU JOUP EFGFDU PQUJDBM BDUJWJUJFT "OPUIFS FYBNQMF BSF XJEF CBOE HBQ TFNJ DPOEVDUPST BT 53-$ JT UIF QFSGFDU UPPM GPS UJNF SFTPMWFE NFBTVSFNFOU PG NBUFSJBMT

TVDI BT #PSPO /JUSJEF "MVNJOJVN /JUSJEF XJUI FNJTTJPO FOFSHJFT VQ UP F7 53-$ QSPWFT UP CF NPSF WFSTBUJMF UIBO MBTFS FYDJUB UJPO TQFDUSPTDPQZ BOE FOTVSFT B SBQJE NFB TVSFNFOU PG EJGGFSFOU TBNQMFT JO TQFDUSBM SBOHFT GSPN VMUSBWJPMFU UP OFBS JOGSBSFE

Annual Activity Report 2009

15

A deep look into the nano cosmos : Time-Resolved Cathodoluminescence TRCL NMMC

Time-resolved cathodoluminescence (TRCL) is the ideal tool to measure dynamics at the nanoscale. “With this spectroscopy technique you select an excitation point, send an electron pulse, collect the outgoing light and resolve it spectrally and temporally”, explains Dr. Samuel Sonderegger.

5IF $&0 PG "UUPMJHIU 4 SM UIF TQFDJBMJTU GPS VMUSBGBTU TQFDUSPTDPQZ GPS /BOP1IPUPOJDT JT JOWPMWFE JO B $$.9 QSPKFDU VOEFS UIF BFHJT PG %S +FBO %BOJFM (BOJ SF BU UIF &1'- -BCPSBUPSZ PG 2VBOUVN 0QUPFMFDUSPOJDT )JT BJN XBT UP QSPEVDF B OFX NFBTVSFNFOU UPPM GPS TFNJDPOEVDUPS OBOPTUSVDUVSFT UIBU DPNCJOFT CPUI IJHI TQBUJBM BOE IJHI UFNQPSBM SFTPMVUJPO 5IF UPPM JT CBTFE PO VMUSBGBTU 53-$ BOE JOUFHSBUFT UIF BEWBOUBHF PG FMFDUSPO NJDSPTDPQZ IJHI TQBUJBM SFTPMVUJPO BOE VMUSBGBTU PQUJDT IJHI UFNQPSBM SFTPMVUJPO "O PQUJDBMMZ HFOFSBUFE VMUSBGBTU QVMTFE FMFDUSPO CFBN JT GPDVTFE POUP B TQFDJNFO BOE JOGPSNBUJPO PO UIF FMFDUSPO EZOBNJDT JT PCUBJOFE CZ SFTPMWJOH TQFDUSBMMZ BOE UFNQPSBMMZ UIF PVUHPJOH DBUIPEPMVNJOFTDFODF TJHOBM 8JUI JOEVTUSJBM BQQMJDBUJPOT JO NJOE UIF &1'- TDJFOUJTUT XBOUFE UP BDIJFWF B DPTU FGGFDUJWF TPMVUJPO XJUI B DPNQBDU NBHOFUJD FMFDUSPTUBUJD 4&. 4DBOOJOH &MFDUSPO .JDSPTDPQF DPMVNO FRVJQQFE XJUI BO PQUJDBMMZ ESJWFO FMFDUSPO TPVSDF 'PS UIF HVO PG UIFJS FMFDUSPO NJDSPTDPQF UIFZ VTFE VMUSB IJHI WBDVVN UFDIOPMPHZ BOE JNNFSTFE UIF DBUIPEF UJQ JO UIF NBHOF UJD GJFME PG UIF HVO MFOT 5XP FMFDUSPTUBUJD PDUPQPMFT BSF MPDBUFE JO UIF QPMF QJFDF PG UIF HVO MFOT GPS NFBTVSJOH UIF WJSUVBM TPVSDF TJ[F PG UIF QIPUPDBUIPEF 5ISFF NPWBCMF BQFSUVSFT TFSWF GPS UIF WJSUVBM TPVSDF NFBTVSFNFOU BOE UP DPOUSPM UIF GJOBM TQBUJBM SFTPMVUJPO PG UIF TZTUFN 5IF CPEZ PG UIF PCKFDUJWF MFOT DPOUBJOT B MJOFBS

14

Annual Activity Report 2009

UVCF DSFBUJOH B WBDVVN BMPOH UIF PQUJDBM BYJT BOE LFFQJOH UIF FMFDUSPNBHOFUJD DPJMT PVUTJEF 5IF DPJMT MPDBUFE JO UIF VQQFS QBSU PG UIF PCKFDUJWF TFSWF BT TUJHNBUPS BOE EFGMFDUPS UP TIBQF UIF FMFDUSPO CFBN UIPTF XIJDI BSF JO UIF MPXFS QBSU PG UIF PCKFDUJWF BDU BT TDBOOJOH DPJMT 5IF NBJO DIBNCFS NBEF PG NBTTJWF JSPO QSPUFDUT UIF TBNQMF TUBHF BOE UIF CFBN GSPN NF DIBOJDBM WJCSBUJPOT BOE FMFDUSPNBHOFUJD JOUFSGFSFODFT 5IF EFUFDUJPO JT DBSSJFE PVU PO POF IBOE CZ B TFDPOEBSZ FMFDUSPO EFUFDUPS MPDBUFE PO POF PG UIF TJEF XBMMT PG UIF DIBNCFS BOE PO UIF PUIFS IBOE CZ B TJNQMF TPMJE TUBUF EFUFDUPS MPDBUFE JOTJEF UIF HBQ PG UIF PCKFDUJWF MFOT XPSLJOH XJUI CBDLTDBUUFSFE FMFDUSPOT %VSJOH UIF XIPMF QSPKFDU UIFSF XBT B DMPTF DPMMBCPSBUJPO XJUI UIF JOEVTUSJBM QBSUOFS "UUPMJHIU T DSFX QSPEVDFE UIF GJCFS CBTFE QPJOUFE QIPUP DBUIPEF GPS UIF HFOFSBUJPO PG QIPUPFMFDUSPOT BOE QSPWJEFE UIF 67 MBTFS OFDFTTBSZ UP UFTU UIF EFWJDF "U UIF FOE PG %S +FBO %BOJFM (BOJ SF HJWFT B QPTJUJWF TVNNBSZ Ä"DUVBMMZ XF IBE QMBOOFE UP SFBDI ON VTJOH FMFDUSPTUBUJD MFOTFTÅ IF DPNNFOUT Ä#VU EVSJOH UIF EFTJHO QIBTF JU UVSOFE PVU UIBU NBHOFUJD MFOTFT XPVME CF NPSF TVJUBCMF UIBO FMFDUSPTUBUJD POFT 8F PQUJNJ[FE UIFN BOE UIJT ZJFMEFE B ON SFTPMVUJPO 5IFO UIF FMFDUSPO PQUJDT XFSF CVJMU BOE B TQBUJBM SFTPMVUJPO PG ON XBT BDIJFWFE Å 'PS QSPEVDUJPO DPTU SFBTPOT UIF SFTFBSDIFST IBE QMBOOFE UP XPSL BU B GJYFE BDDFMFSBUJPO WPMUBHF PG L7 *O UIF

DPVSTF PG UIFJS TUVEJFT UIFZ SFBMJ[FE UIBU XJUI NBHOFUJD MFOTFT UIFZ DPVME HFU B UVOFBCMF BDDFMFSBUJPO WPMUBHF CFUXFFO L7 5IBU XBT HPPE OFXT GPS +FBO %BOJFM (BOJ SF Ä-PX BDDFMFSBUJPO WPMUBHFT BSF DSVDJBM GPS BQQMJDBUJPOT PO QPMZNFST BOE

CJPMPHJDBM TBNQMFT Å 5IF SFTVMUT PG UIF $$.9 QSPKFDU PQFO VQ OFX IPSJ[POT GPS UIF TFNJDPOEVDUPS JOEVTUSZ BOE "UUPMJHIU JT HPJOH UP MBVODI UIF QSPEVDU PO UIF NBSLFU $PODSFUF BQQMJDBUJPOT BSF GPS JOTUBODF UIF EFGFDU BOBMZTJT JO (BMMJVN OJUSJEF -PDBM

MJGFUJNF NFBTVSFNFOUT CSJOH UIF UFNQPSBM EJNFOTJPO UP EFGFDU BOBMZTJT QSPWJEJOH GVSUIFS JOTJHIU JOUP EFGFDU PQUJDBM BDUJWJUJFT "OPUIFS FYBNQMF BSF XJEF CBOE HBQ TFNJ DPOEVDUPST BT 53-$ JT UIF QFSGFDU UPPM GPS UJNF SFTPMWFE NFBTVSFNFOU PG NBUFSJBMT

TVDI BT #PSPO /JUSJEF "MVNJOJVN /JUSJEF XJUI FNJTTJPO FOFSHJFT VQ UP F7 53-$ QSPWFT UP CF NPSF WFSTBUJMF UIBO MBTFS FYDJUB UJPO TQFDUSPTDPQZ BOE FOTVSFT B SBQJE NFB TVSFNFOU PG EJGGFSFOU TBNQMFT JO TQFDUSBM SBOHFT GSPN VMUSBWJPMFU UP OFBS JOGSBSFE

Annual Activity Report 2009

15

Opening up new markets with ingenious neo-metallurgy MERU

Today, there is a high demand for new sophisticated metallic alloys to meet the evolving requirements of the power generation, petrochemical and aerospace industrial sectors.

To tailor them for specific structural or functional applications, insight into the phenomena defining their thermo-mechanical behaviour needs to be gained.

0.5 µm

0.5 µm

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

16

Annual Activity Report 2009

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

UIFZ IBE SFDPVSTF UP 5&. 5SBOTNJTTJPO &MFDUSPO .JDSPTDPQZ &#4% &MFDUSPO #BDL 4DBUUFS %JGGSBDUJPO BOE 4&. #4& 4DBOOJOH &MFDUSPO .JDSPTDPQZ JO #BDLTDBUUFSFE &MFDUSPO .PEF " DPNQMFNFOUBSZ DPOUSJCVUJPO XBT NBEF CZ UIF /VDMFBS 1IZTJDT *OTUJUVUF PG UIF "DBEFNZ PG 4DJFODFT PG UIF $[FDI 3FQVCMJD $/1*

XIJDI BDDPNQMJTIFE UIF EJTMPDBUJPO EFOTJUZ NFBTVSFNFOUT JO JOUFSSVQUFE GBUJHVF TQFDJNFOT " NBTUFS TUVEFOU QSPKFDU FYBNJOFE UIF BQQMJDBCJMJUZ PG B OVNCFS PG DZDMJD QMBTUJDJUZ NPEFMT UP CPUI PG UIF UXP TUFFM WBSJFUJFT 5IF SFTFBSDI BDUJWJUJFT BSF WFSZ DPNQMFY BOE JOWPMWF

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

BJNT UP VOEFSTUBOE UIF NFDIBOJTNT XIJDI EFUFSNJOF UIF SFMBUJPOTIJQ CFUXFFO UIF NJDSPTUSVDUVSFT JO BEWBODFE BMMPZT BOE UIFJS EFGPSNBUJPO CFIBWJPVS 8IJMF QFSGPSNJOH NFDIBOJDBM UFTUJOH EVSJOH OFVUSPO BOE PS 9 SBZ EJGGSBDUJPO UIF TDJFOUJTUT XBOU UP EFNPOTUSBUF UIF QPUFOUJBM PG JO TJUV UFDIOJRVFT GPS VOEFSTUBOEJOH UIF EZOBNJDBM CFIBWJPVS PG UIF NJDSP TUSVDUVSF EVSJOH MPBEJOH 5IF QSPKFDU GPDVTFT PO UXP UZQFT PG BMMPZT 5IF GJSTU UZQF BSF /J CBTFE TJOHMF DSZTUBM TVQFSBMMPZT VTFE JO UVSCJOF CMBEFT UIJT UXP QIBTF TVC NJDSPO TUSVDUVSFE NBUFSJBM JT LOPXO UP DPBSTFO EVSJOH UIF BQQMJDBUJPO PG TUSFTT

BOE UFNQFSBUVSF B QSPDFTT UIBU BMUFST UIF NBUFSJBM T QFSGPSNBODF 5IF TFDPOE UZQF BSF DSFFQ SFTJTUBOU TUFFMT XIFSF UIF SFQBSUJUJPO PG TUSFTTFT BOE TUSBJOT PWFS UIF EJGGFSFOU DPOTUJUVFOU QIBTFT JT TUVEJFE 5IF VOEFSTUBOEJOH PG UIF MPBE QBSUJUJPOJOH JO SFMBUJPO UP UIF NJDSPTUSVDUVSF TIPVME QSPWJEF WBMVBCMF JOQVU GPS QSFEJDUJWF NPEFMMJOH PG UIF NBUFSJBMT CFIBWJPVS JO TFSWJDF UZQF DPOEJUJPOT

Annual Activity Report 2009

17

Opening up new markets with ingenious neo-metallurgy MERU

Today, there is a high demand for new sophisticated metallic alloys to meet the evolving requirements of the power generation, petrochemical and aerospace industrial sectors.

To tailor them for specific structural or functional applications, insight into the phenomena defining their thermo-mechanical behaviour needs to be gained.

0.5 µm

0.5 µm

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

16

Annual Activity Report 2009

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

UIFZ IBE SFDPVSTF UP 5&. 5SBOTNJTTJPO &MFDUSPO .JDSPTDPQZ &#4% &MFDUSPO #BDL 4DBUUFS %JGGSBDUJPO BOE 4&. #4& 4DBOOJOH &MFDUSPO .JDSPTDPQZ JO #BDLTDBUUFSFE &MFDUSPO .PEF " DPNQMFNFOUBSZ DPOUSJCVUJPO XBT NBEF CZ UIF /VDMFBS 1IZTJDT *OTUJUVUF PG UIF "DBEFNZ PG 4DJFODFT PG UIF $[FDI 3FQVCMJD $/1*

XIJDI BDDPNQMJTIFE UIF EJTMPDBUJPO EFOTJUZ NFBTVSFNFOUT JO JOUFSSVQUFE GBUJHVF TQFDJNFOT " NBTUFS TUVEFOU QSPKFDU FYBNJOFE UIF BQQMJDBCJMJUZ PG B OVNCFS PG DZDMJD QMBTUJDJUZ NPEFMT UP CPUI PG UIF UXP TUFFM WBSJFUJFT 5IF SFTFBSDI BDUJWJUJFT BSF WFSZ DPNQMFY BOE JOWPMWF

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

BJNT UP VOEFSTUBOE UIF NFDIBOJTNT XIJDI EFUFSNJOF UIF SFMBUJPOTIJQ CFUXFFO UIF NJDSPTUSVDUVSFT JO BEWBODFE BMMPZT BOE UIFJS EFGPSNBUJPO CFIBWJPVS 8IJMF QFSGPSNJOH NFDIBOJDBM UFTUJOH EVSJOH OFVUSPO BOE PS 9 SBZ EJGGSBDUJPO UIF TDJFOUJTUT XBOU UP EFNPOTUSBUF UIF QPUFOUJBM PG JO TJUV UFDIOJRVFT GPS VOEFSTUBOEJOH UIF EZOBNJDBM CFIBWJPVS PG UIF NJDSP TUSVDUVSF EVSJOH MPBEJOH 5IF QSPKFDU GPDVTFT PO UXP UZQFT PG BMMPZT 5IF GJSTU UZQF BSF /J CBTFE TJOHMF DSZTUBM TVQFSBMMPZT VTFE JO UVSCJOF CMBEFT UIJT UXP QIBTF TVC NJDSPO TUSVDUVSFE NBUFSJBM JT LOPXO UP DPBSTFO EVSJOH UIF BQQMJDBUJPO PG TUSFTT

BOE UFNQFSBUVSF B QSPDFTT UIBU BMUFST UIF NBUFSJBM T QFSGPSNBODF 5IF TFDPOE UZQF BSF DSFFQ SFTJTUBOU TUFFMT XIFSF UIF SFQBSUJUJPO PG TUSFTTFT BOE TUSBJOT PWFS UIF EJGGFSFOU DPOTUJUVFOU QIBTFT JT TUVEJFE 5IF VOEFSTUBOEJOH PG UIF MPBE QBSUJUJPOJOH JO SFMBUJPO UP UIF NJDSPTUSVDUVSF TIPVME QSPWJEF WBMVBCMF JOQVU GPS QSFEJDUJWF NPEFMMJOH PG UIF NBUFSJBMT CFIBWJPVS JO TFSWJDF UZQF DPOEJUJPOT

Annual Activity Report 2009

17

How to make use of modelling techniques for metallic systems MERU

Computer simulation is a very helpful tool in metallurgy as it makes it possible to model, understand and optimize processes to obtain the best material properties with specific characteristics.

Especially multi-scale modelling which allows different aspects of materials science and engineering to be linked from the atomistic to the process scale. Professor Michel Rappaz, who leads the Computational Materials Laboratory at EPFL and the CCMX Education & Research Unit on Metallurgy (MERU) agreed to answer a few questions.

1. Are numerical modelling techniques the ideal tools for materials research and development ? .3 .BUFSJBMT BSF BU UIF JOUFSTFDUJPO QPJOU PG EJGGFSFOU EJTDJQMJOFT GSPN CBTJD SFTFBSDI UP BQQMJFE UFDIOPMPHZ "T TVDI UIFZ DPN QSJTF NVMUJQMF TDBMFT PG MFOHUI BOE UJNF GSPN UIF BUPNJD TUSVDUVSF UP QSPDFTTFT PS DPNQPOFOU EJNFOTJPOT 5IF NPEFMMJOH UPPMT GPS NBUFSJBMT EFWFMPQFE JO UIF MBTU UISFF EFDBEFT CZ NBUIFNBUJDJBOT QIZTJ DJTUT DIFNJTUT BOE FOHJOFFST BSF JODSFBT JOHMZ NPSF DPNQSFIFOTJWF JNQPSUBOU BOE IFMQGVM GPS TDJFOUJTUT BOE FOHJOFFST

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Annual Activity Report 2009

2. Can you name some running projects funded by CCMX in which such techniques play a role ? .3 *O POF QSPKFDU XJUI TFWFSBM BDBEFNJD BOE JOEVTUSJBM QBSUOFST HSBOVMBS EZOBNJDT BOE QIBTF GJFME BQQSPBDIFT BSF EFWFMPQFE UP TUVEZ UIF GPSNBUJPO PG EFGFDUT JO TPMJEJGJDBUJPO QSPDFTTFT OBNFMZ NJDSP QPSPTJUZ BOE IPU UFBSJOH 5IFTF UXP NBKPS EFGFDUT PDDVS EVSJOH TPMJEJGJDBUJPO PG NFUBMMJD BMMPZT BT B SFTVMU PG B MBDL PG MJRVJE GFFEJOH UP DPNQFOTBUF TISJOLBHF BOE EFGPSNBUJPOT "OPUIFS DP PQFSBUJPO XJUI JOEVTUSZ EFBMT XJUI B DPNCJOBUPSZ TUVEZ

BOE UIF NPEFMMJOH PG PQUJDBM QSPQFSUJFT PG HPME BMMPZT BT UIFZ BSF BQQMJFE JO UIF KFXFMMFSZ BOE XBUDI JOEVTUSZ 5XP PUIFS QSPKFDUT EFBMJOH XJUI NFDIBOJDBM QSPQFSUJFT PG NFUBMMJD BMMPZT IBWF BO JNQPSUBOU TJNVMBUJPO BTQFDU BT XFMM

3. Where do you locate the challenge in using modelling for materials in an efficient way ? .3 0O POF IBOE JU JT FTTFOUJBM UP DIPPTF UIF BQQSPQSJBUF UPPM GPS TPMWJOH B TQFDJGJD QSPCMFN 0O UIF PUIFS IBOE JU JT JNQPSUBOU UP NBOBHF UIF FYDIBOHF PG JOGPSNBUJPO

CFUXFFO NPEFMT EFWFMPQFE PO EJGGFSFOU TDBMFT ‡ BUPN HSBJO PCKFDU ‡ JO BO BEFRVBUF XBZ

4. Is that where the CCMX network provides expert services ? .3 0VS UBTL JT UP DBSSZ PVU SFTFBSDI BOE DPOUJOVJOH FEVDBUJPO JO BEWBODFE UFDIOP MPHJFT 0O UIF PDDBTJPO PG B 5FDIOPMPHZ "QFSJUJG ‡ BO FWFOU XF PSHBOJ[F PO B SFHVMBS CBTJT BT B NFFUJOH QMBDF GPS SFTFBSDIFST EFWFMPQFST BOE NBSLFUJOH QFPQMF ‡ WJTJUPST BTLFE VT UP QSPWJEF JOGPSNBUJPO PO UIF QPTTJCJMJUJFT PG

NPEFMMJOH GPS UIF EFWFMPQNFOU PG NBUF SJBMT *O "VHVTU JO BOTXFS UP UIJT SFRVFTU XF PSHBOJTFE B UISFF EBZ 4VNNFS 4DIPPM PO .PEFMMJOH JO .BUFSJBMT 4DJFODF XJUI TQFDJBMJTUT GSPN BMM PWFS &VSPQF BOE UIF 64" 5IF IJHI BUUFOEBODF DPOGJSNFE UIF HSFBU JOUFSFTU GPS TVDI UPQJDT

5. Can you give interested parties from industry any advice ? .3 5IF GJSTU UIJOH JT UP DPOTJEFS QSFDJTFMZ XIBU ZPV FYQFDU GSPN NPEFMMJOH TPGUXBSF CFGPSF ZPV HFU JOWPMWFE JO UIJT EPNBJO 4FDPOEMZ BMMPX TPNF UJNF UP CVJME VQ BO

FYQFSUJTF BOE B DFSUBJO ‰DVMUVSFŠ PG NPEFMMJOH JO ZPVS DPNQBOZ " HPPE FYBNQMF JO UIJT SFTQFDU JT UIF NPEFMMJOH PG TPMJEJGJDBUJPO QSPDFTTFT PG UVSCJOF CMBEFT GPS XIJDI UIF &1'- ‡ UPHFUIFS XJUI &VSPQFBO BOE "NFSJDBO JOEVTUSJFT ‡ IBT EFWFMPQFE TPQIJTUJDBUFE UPPMT GPS NBOZ ZFBST 8JUIJO $$.9 BOE .&36 JO QBSUJDVMBS JOEVTUSJBM QBSUOFST DBO GJOE TQFDJBMJTUT XIP DBO HJWF UIFN BEWJDF PO IPX UP NBLF PQUJNBM VTF PG UIFTF NPEFMMJOH UPPMT

Annual Activity Report 2009

19

How to make use of modelling techniques for metallic systems MERU

Computer simulation is a very helpful tool in metallurgy as it makes it possible to model, understand and optimize processes to obtain the best material properties with specific characteristics.

Especially multi-scale modelling which allows different aspects of materials science and engineering to be linked from the atomistic to the process scale. Professor Michel Rappaz, who leads the Computational Materials Laboratory at EPFL and the CCMX Education & Research Unit on Metallurgy (MERU) agreed to answer a few questions.

1. Are numerical modelling techniques the ideal tools for materials research and development ? .3 .BUFSJBMT BSF BU UIF JOUFSTFDUJPO QPJOU PG EJGGFSFOU EJTDJQMJOFT GSPN CBTJD SFTFBSDI UP BQQMJFE UFDIOPMPHZ "T TVDI UIFZ DPN QSJTF NVMUJQMF TDBMFT PG MFOHUI BOE UJNF GSPN UIF BUPNJD TUSVDUVSF UP QSPDFTTFT PS DPNQPOFOU EJNFOTJPOT 5IF NPEFMMJOH UPPMT GPS NBUFSJBMT EFWFMPQFE JO UIF MBTU UISFF EFDBEFT CZ NBUIFNBUJDJBOT QIZTJ DJTUT DIFNJTUT BOE FOHJOFFST BSF JODSFBT JOHMZ NPSF DPNQSFIFOTJWF JNQPSUBOU BOE IFMQGVM GPS TDJFOUJTUT BOE FOHJOFFST

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Annual Activity Report 2009

2. Can you name some running projects funded by CCMX in which such techniques play a role ? .3 *O POF QSPKFDU XJUI TFWFSBM BDBEFNJD BOE JOEVTUSJBM QBSUOFST HSBOVMBS EZOBNJDT BOE QIBTF GJFME BQQSPBDIFT BSF EFWFMPQFE UP TUVEZ UIF GPSNBUJPO PG EFGFDUT JO TPMJEJGJDBUJPO QSPDFTTFT OBNFMZ NJDSP QPSPTJUZ BOE IPU UFBSJOH 5IFTF UXP NBKPS EFGFDUT PDDVS EVSJOH TPMJEJGJDBUJPO PG NFUBMMJD BMMPZT BT B SFTVMU PG B MBDL PG MJRVJE GFFEJOH UP DPNQFOTBUF TISJOLBHF BOE EFGPSNBUJPOT "OPUIFS DP PQFSBUJPO XJUI JOEVTUSZ EFBMT XJUI B DPNCJOBUPSZ TUVEZ

BOE UIF NPEFMMJOH PG PQUJDBM QSPQFSUJFT PG HPME BMMPZT BT UIFZ BSF BQQMJFE JO UIF KFXFMMFSZ BOE XBUDI JOEVTUSZ 5XP PUIFS QSPKFDUT EFBMJOH XJUI NFDIBOJDBM QSPQFSUJFT PG NFUBMMJD BMMPZT IBWF BO JNQPSUBOU TJNVMBUJPO BTQFDU BT XFMM

3. Where do you locate the challenge in using modelling for materials in an efficient way ? .3 0O POF IBOE JU JT FTTFOUJBM UP DIPPTF UIF BQQSPQSJBUF UPPM GPS TPMWJOH B TQFDJGJD QSPCMFN 0O UIF PUIFS IBOE JU JT JNQPSUBOU UP NBOBHF UIF FYDIBOHF PG JOGPSNBUJPO

CFUXFFO NPEFMT EFWFMPQFE PO EJGGFSFOU TDBMFT ‡ BUPN HSBJO PCKFDU ‡ JO BO BEFRVBUF XBZ

4. Is that where the CCMX network provides expert services ? .3 0VS UBTL JT UP DBSSZ PVU SFTFBSDI BOE DPOUJOVJOH FEVDBUJPO JO BEWBODFE UFDIOP MPHJFT 0O UIF PDDBTJPO PG B 5FDIOPMPHZ "QFSJUJG ‡ BO FWFOU XF PSHBOJ[F PO B SFHVMBS CBTJT BT B NFFUJOH QMBDF GPS SFTFBSDIFST EFWFMPQFST BOE NBSLFUJOH QFPQMF ‡ WJTJUPST BTLFE VT UP QSPWJEF JOGPSNBUJPO PO UIF QPTTJCJMJUJFT PG

NPEFMMJOH GPS UIF EFWFMPQNFOU PG NBUF SJBMT *O "VHVTU JO BOTXFS UP UIJT SFRVFTU XF PSHBOJTFE B UISFF EBZ 4VNNFS 4DIPPM PO .PEFMMJOH JO .BUFSJBMT 4DJFODF XJUI TQFDJBMJTUT GSPN BMM PWFS &VSPQF BOE UIF 64" 5IF IJHI BUUFOEBODF DPOGJSNFE UIF HSFBU JOUFSFTU GPS TVDI UPQJDT

5. Can you give interested parties from industry any advice ? .3 5IF GJSTU UIJOH JT UP DPOTJEFS QSFDJTFMZ XIBU ZPV FYQFDU GSPN NPEFMMJOH TPGUXBSF CFGPSF ZPV HFU JOWPMWFE JO UIJT EPNBJO 4FDPOEMZ BMMPX TPNF UJNF UP CVJME VQ BO

FYQFSUJTF BOE B DFSUBJO ‰DVMUVSFŠ PG NPEFMMJOH JO ZPVS DPNQBOZ " HPPE FYBNQMF JO UIJT SFTQFDU JT UIF NPEFMMJOH PG TPMJEJGJDBUJPO QSPDFTTFT PG UVSCJOF CMBEFT GPS XIJDI UIF &1'- ‡ UPHFUIFS XJUI &VSPQFBO BOE "NFSJDBO JOEVTUSJFT ‡ IBT EFWFMPQFE TPQIJTUJDBUFE UPPMT GPS NBOZ ZFBST 8JUIJO $$.9 BOE .&36 JO QBSUJDVMBS JOEVTUSJBM QBSUOFST DBO GJOE TQFDJBMJTUT XIP DBO HJWF UIFN BEWJDF PO IPX UP NBLF PQUJNBM VTF PG UIFTF NPEFMMJOH UPPMT

Annual Activity Report 2009

19

Flame Spray Deposition at low temperature Surface treatment by coating and structuring SPERU

They may revolutionise technological devices and open up multibillion dollar markets. “ They ” are the electroceramic thin films that show great potential for entirely new generations of advanced micro-devices as they offer huge functionalities which traditional semiconductor materials such as Silicon (Si) or Gallium Arsenide (GaAs) cannot provide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Annual Activity Report 2009

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BMM UIF BEWBOUBHFT PG UIF 'MBNF 4QSBZ %FQPTJUJPO QSPDFTT TVDI BT IJHI QSPEVD UJPO SBUFT MPX DPTU GPS SBX NBUFSJBMT FBTZ UP TDBMF VQ BOE SFMBUJWFMZ TUSBJHIUGPSXBSE UP PQFSBUF 5IF TDJFOUJTU XIP NPWFE UP &NQB UP QSFQBSF IJT 1I% JO OBOPUFDIOP MPHZ TFFT B CSJHIU GVUVSF GPS TVSGBDF NPEJGJDBUJPO Ä 8F TFMFDU B NBUFSJBM BOE GVODUJPOBMJ[F JUT TVSGBDF QSPWJEJOH JU XJUI FOIBODFE DIBSBDUFSJTUJDT TVDI BT IJHI FMFDUSJDBM DPOEVDUJWJUZ SFGMFDUJWJUZ PS NFDIBOJDBM TUBCJMJUZ Å "MUIPVHI CVJMEJOH B NJDSP 4PMJE 0YJEF 'VFM $FMM XBT B NBJO GPDVT PG UIF /"/$&3 QSPKFDU BOE XIJMF

UIJT UBSHFU JT FYUSFNFMZ EFNBOEJOH JO UFSNT PG NBUFSJBMT BOE QSPDFTTJOH UIF SFTVMUT EFWFMPQFE TP GBS BSF OPU MJNJUFE UP 40'$ Ä 4VSGBDF USFBUNFOU JT WFSZ JNQPSUBOU JO WBSJPVT BQQMJDBUJPOT JO FWFSZEBZ MJGF GPS JOTUBODF DPBUJOHT JOTJEF QMBTUJD CBHT GPS GPPE QSFTFSWBUJPO JO BVUPNPUJWF JOEVTUSZ GPS QBJOUT JO FOFSHZ SFMBUFE EFWJDFT TVDI BT UPVDI TDSFFOT GPS NPCJMF QIPOFT JO HMBTT JOEVTUSZ UP DSFBUF SFGMFDUJOH DPBUJOHT Å 5IF DPBUJOH JOEVTUSZ DBO SFBMMZ CFOFGJU GSPN UIF OFX LOPXMFEHF HFOFSBUFE EVSJOH UIF /"/$&3 QSPKFDU UP JOOPWBUF BOE CSFBL JOUP OFX NBSLFUT

Annual Activity Report 2009

21

Flame Spray Deposition at low temperature Surface treatment by coating and structuring SPERU

They may revolutionise technological devices and open up multibillion dollar markets. “ They ” are the electroceramic thin films that show great potential for entirely new generations of advanced micro-devices as they offer huge functionalities which traditional semiconductor materials such as Silicon (Si) or Gallium Arsenide (GaAs) cannot provide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Annual Activity Report 2009

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

XPVME JU CF QPTTJCMF UP EFQPTJU EFOTF UIJO GJMNT BU BCPVU k$ Ä *O UIF GJSTU ZFBS * BMNPTU EFTQBJSFE BT XF EJE OPU TVDDFFE JO BDIJFWJOH B UIJO DPBUJOH CZ GMBNF GPS TQFDJGJD DFSBNJD NBUFSJBMT Å SFNFNCFST UIF NFDIBOJDBM FOHJOFFS XIP QSFWJPVTMZ XPSLFE BU UIF &5) ;VSJDI HSPVQ PG UVSCP NBDIJOFSZ Ä #VU JO FBSMZ XF TVDDFFEFE JO DIBSBDUFSJTJOH UIF GMBNF EFQPTJUJPO QSPDFTT BOE CFHBO UP VOEFS TUBOE JUT NFDIBOJTN Å 5IJT XBT B SFBM CSFBLUISPVHI 8JUI UIFJS OFX GJOEJOHT UIFZ DBO LOPX EFQPTJU EJGGFSFOU NBUFSJBMT TVDI BT EFOTF TVC NJDSPO GJMNT BU UFNQF

SBUVSFT BT MPX BT k$ Ä5IF QSPDFTT DBO QPUFOUJBMMZ CF VTFE GPS UIJO GJMN EFQPTJUJPO PO QPMZNFS TVCTUSBUFT 5IJT XBT OPU QPTTJCMF UISFF ZFBST BHPÅ TUBUFT /JLPMBPT ,BSBHFPSHBLJT Ä5IJT BMMPXT GPS UIF GJSTU UJNF UIF EFQPTJUJPO PG DPBUJOHT PO UFNQFSBUVSF TFOTJUJWF TVCTUSBUF NBUFSJBMT TVDI BT QPMZNFST XIJDI IBWF UIF BCJMJUZ UP CFOE BOE DSFBUF GMFYJCMF QSPEVDUT CVU BMTP NFMU XIFO IFBUFE PWFS k$ k$ Å 5IFTF SFTVMUT PQFO VQ B SBOHF PG OFX QPTTJCJMJUJFT UP DPNQBOJFT BDUJWF JO UIF DPBUJOH CVTJOFTT 5IFZ DPVME OPX FYQMPJU

BMM UIF BEWBOUBHFT PG UIF 'MBNF 4QSBZ %FQPTJUJPO QSPDFTT TVDI BT IJHI QSPEVD UJPO SBUFT MPX DPTU GPS SBX NBUFSJBMT FBTZ UP TDBMF VQ BOE SFMBUJWFMZ TUSBJHIUGPSXBSE UP PQFSBUF 5IF TDJFOUJTU XIP NPWFE UP &NQB UP QSFQBSF IJT 1I% JO OBOPUFDIOP MPHZ TFFT B CSJHIU GVUVSF GPS TVSGBDF NPEJGJDBUJPO Ä 8F TFMFDU B NBUFSJBM BOE GVODUJPOBMJ[F JUT TVSGBDF QSPWJEJOH JU XJUI FOIBODFE DIBSBDUFSJTUJDT TVDI BT IJHI FMFDUSJDBM DPOEVDUJWJUZ SFGMFDUJWJUZ PS NFDIBOJDBM TUBCJMJUZ Å "MUIPVHI CVJMEJOH B NJDSP 4PMJE 0YJEF 'VFM $FMM XBT B NBJO GPDVT PG UIF /"/$&3 QSPKFDU BOE XIJMF

UIJT UBSHFU JT FYUSFNFMZ EFNBOEJOH JO UFSNT PG NBUFSJBMT BOE QSPDFTTJOH UIF SFTVMUT EFWFMPQFE TP GBS BSF OPU MJNJUFE UP 40'$ Ä 4VSGBDF USFBUNFOU JT WFSZ JNQPSUBOU JO WBSJPVT BQQMJDBUJPOT JO FWFSZEBZ MJGF GPS JOTUBODF DPBUJOHT JOTJEF QMBTUJD CBHT GPS GPPE QSFTFSWBUJPO JO BVUPNPUJWF JOEVTUSZ GPS QBJOUT JO FOFSHZ SFMBUFE EFWJDFT TVDI BT UPVDI TDSFFOT GPS NPCJMF QIPOFT JO HMBTT JOEVTUSZ UP DSFBUF SFGMFDUJOH DPBUJOHT Å 5IF DPBUJOH JOEVTUSZ DBO SFBMMZ CFOFGJU GSPN UIF OFX LOPXMFEHF HFOFSBUFE EVSJOH UIF /"/$&3 QSPKFDU UP JOOPWBUF BOE CSFBL JOUP OFX NBSLFUT

Annual Activity Report 2009

21

From ice cream to foams and micro-capsules SPERU

What do whipped cream and ice cream have in common?

They are so called Pickering emulsions, in the former case stabilized by fat particles, the latter one stabilized by ice crystals.

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22

Annual Activity Report 2009

Ä 8F QSPEVDFE TPMJE GPBNT PVU PG DFSBNJDT NFUBMT QPMZNFST BOE DPNQPTJUF NBUFSJBMT *U XBT JO GBDU QPTTJCMF UP PCUBJO SPCVTU GPBNT GSPN IJHIMZ JOGMBNNBCMF NFUBM QBSUJDMFT B SFBM DIBMMFOHF Å DPNNFOUT %S 6ST (PO[FOCBDI TDJFOUJTU JO UIF UFBN PG 1SPGFTTPS -VEXJH (BVDLMFS PG /PO NFUBMMJD *OPSHBOJD .BUFSJBMT BU &5) ;VSJDI Ä 8F EFWFMPQFE B QSPDFEVSF UP BDIJFWF PQFO QPSFT PG ñN JO DFSBNJD GPBNT XJUI DPOUSPMMFE QPSF TJ[FT BOE BQFSUVSFT BOE BU UIF TBNF UJNF IJHI NFDIBOJD TUBCJMJUZ Å *O UIF DPVSTF PG UIFJS XPSL UIF FOHJOFFST BMTP DBNF VQ XJUI B QSPDFTTJOH DIBJO GPS TUJGG GPBNT NBEF GSPN 5J BOE /J 5J OBOP QBSUJDMFT JO BO PYZHFO GSFF BUNPTQIFSF Ä 5IF PYZHFO DPOUFOU PG MFTT UIBO NBTT QFSDFOU JO ESZ QPSPVT NBUFSJBM BOE UIF BWFSBHF QPSF TJ[F PG MFTT UIBO ñN MPPL WFSZ QSPNJTJOH Å QSPVEMZ TBZT UIF &5) ;VSJDI SFTFBSDIFS 5P CSJOH UIF QBUFOUFE SFTVMUT UP NBSLFU 6ST (PO[FOCBDI DP JOWFOUPS PG UIF UFDIOPMPHZ FTUBCMJTIFE IJT PXO DPNQBOZ XJUI UIF IFMQ PG IJT DPMMFBHVFT BO &5) TQJO PGG EF $BWJT "( #BTFE PO UIF &5) ;VSJDI QMBUGPSN EF $BWJT "( EFWFMPQT BOE NBSLFUT JOPSHBOJD QPSPVT NBUFSJBMT TVJUBCMF XIFSFWFS UIFSF JT B EFNBOE GPS TBWJOH IFBU MPTT BOE DPTU DVUUJOH "SFBT PG

BQQMJDBUJPO BSF JOEVTUSJBM QMBOUT BOE GVSOBDFT XIFSF UIF UFNQFSBUVSF FYDFFET k$ 0OF PG IJT USVNQ DBSET JT UIF DPOUSPMMFE GPSNBUJPO PG XFU GPBNT BOE FNVMTJPOT XJUI EJGGFSFOU DPNQPTJUJPOT BOE NJDSP TUSVDUVSFT Ä "T UIF GPBNT BOE FNVMTJPOT TIPX IJHI TUBCJMJUZ JO UIFJS XFU TUBUF XF DBO QSPDFTT UIFN UP QPSPVT GJCSF GSFF NBUFSJBMT PS TPMJE DPBUFE NJDSP DBQTVMFT XJUI QBSUJDVMBS DIBSBDUFSJTUJDT Å FYQMBJOT 6ST (PO[FOCBDI )F TFFT BQQMJDBUJPOT BT UIFSNBM JOTVMBUJPO BOE MJHIU XFJHIU DPOTUSVDUJPO NBUFSJBMT CVU BMTP BT NJDSP DBQTVMFT XJUI B TQFDJBM TUSVDUVSF GPS UIF FODBQTVMBUJPO BOE SFMFBTF PG DIFNJDBM DPNQPOFOUT GPS JOTUBODF JO DPTNFUJDT BOE CJP NFEJDJOF BOE DBUBMZTJT 5IF NJDSP DBQTVMFT DBO CF NBEF GSPN EJGGFSFOU SBX NBUFSJBMT BOE DVTUPNJ[FE CZ TJ[F BOE QFSNFBCJMJUZ Ä *OPSHBOJD TPMJE DPBUFE NJDSP DBQTVMFT BSF NPSF BEWBOUBHFPVT UIBO QPMZNFS BOE UFOTJMF CBTFE TZTUFNT CFDBVTF PG UIFJS WFSZ HPPE DIFNJDBM BOE IFBU TUBCJMJUZ Å UIF ZPVOH FOUSFQSFOFVS FYQMBJOT 8JUI UIFJS TNBSU GVODUJPOBM GPBNT JOWFOUFE BU &5) ;VSJDI BOE GVSUIFS EFWFMPQFE XJUIJO UIF $$.9 QSPHSBNNF UIF TDJFOUJTUT TFU B OFX TUBOEBSE JO UIF QSPNJTJOH EPNBJO PG NBUFSJBMT UFDIOPMPHZ

4JOUFSFE BMVNJOJVN PYJEF GPBNT XJUI QPSFT PG EJGGFSFOU TJ[FT &WFO UIPVHI UIFZ DPOTJTU PG BJS UIFZ BSF PG IJHI NFDIBOJDBM TUBCJMJUZ 1JDUVSF EF $BWJT

20 µm

4DBOOJOH FMFDUSPO NJDSPTDPQF QJDUVSF PG UIJO BMVNJOJVN PYJEF XBMMT TFQBSBUJOH FBDI TJOHMF QPSF PG UIF DFSBNJD NBUFSJBM 1JDUVSF EF $BWJT

1 cm

100 µm

Annual Activity Report 2009

23

From ice cream to foams and micro-capsules SPERU

What do whipped cream and ice cream have in common?

They are so called Pickering emulsions, in the former case stabilized by fat particles, the latter one stabilized by ice crystals.

5IJT QSJODJQMF JT UIF CBTJT GPS UIF EFWFMPQNFOU PG OPWFM GPBNT XJUI UBJMPS NBEF QPSPTJUZ QPSF TJ[F EJTUSJCVUJPO BOE QPSF DPOOFDUJWJUZ CZ NBUFSJBMT TQFDJBMJTUT BU &5) ;VSJDI BOE &1'- XJUIJO UIF $$.9 GVOEFE QSPKFDU 4NBSU 'VODUJPOBM 'PBNT 5IF TDJFOUJTUT VTF TVSGBDF NPEJGJFE DPMMPJEBM QBSUJDMFT BT GPBN TUBCJMJ[FST 5IF SFTVMUJOH XFU GPBNT BSF TUBCMF GPS MPOH QFSJPET PG UJNF XIJDI BMMPXT GPS BO JNQSPWFE DPOUSPM PG UIF JOOFS GPBN NJDSP TUSVDUVSF 5IJT JT B QSFSFRVJTJUF GPS B XFMM DPOUSPMMFE GBCSJDBUJPO PG QPSPVT TUSVDUVSF XJUI EFGJOFE QPSPTJUZ BOE QPSF TJ[FT BOE FYDFQUJPOBM QSPQFSUJFT 0O UIF CBTJT PG UIFTF 1JDLFSJOH FNVMTJPOT UIF SFTFBSDIFST QSPEVDF QPSPVT NBUFSJBMT GSPN BOZ QPXEFST NBZ JU CF QPMZNFST NFUBMT PS DFSBNJDT 5IF NJDSP TUSVDUVSF PG UIFTF GPBNT BGUFS DPOTPMJEBUJPO DBO CF UBJMPSFE JO B CSPBE SBOHF DPODFSOJOH UIF QPSPTJUZ BOE UIF TJ[F PG UIF QPSFT 1PSPTJUZ DBO SBOHF GSPN BOZUIJOH BSPVOE VQ UP BOE UIF BWFSBHF QPSF TJ[FT DBO SBOHF GSPN ñN UP NN &WFO UIF QFSNFBCJMJUZ PG HBT PS MJRVJET DBO CF BEKVTUFE JO B XJEF SBOHF 5IFSFGPSF UIF GPBNT BSF QSPNJTJOH DBOEJEBUFT GPS OPWFM CPOF HSBGUT BOE FGGJDJFOU JOTVMBUJPO NBUFSJBMT GPS UFNQFSBUVSFT VQ UP k$

22

Annual Activity Report 2009

Ä 8F QSPEVDFE TPMJE GPBNT PVU PG DFSBNJDT NFUBMT QPMZNFST BOE DPNQPTJUF NBUFSJBMT *U XBT JO GBDU QPTTJCMF UP PCUBJO SPCVTU GPBNT GSPN IJHIMZ JOGMBNNBCMF NFUBM QBSUJDMFT B SFBM DIBMMFOHF Å DPNNFOUT %S 6ST (PO[FOCBDI TDJFOUJTU JO UIF UFBN PG 1SPGFTTPS -VEXJH (BVDLMFS PG /PO NFUBMMJD *OPSHBOJD .BUFSJBMT BU &5) ;VSJDI Ä 8F EFWFMPQFE B QSPDFEVSF UP BDIJFWF PQFO QPSFT PG ñN JO DFSBNJD GPBNT XJUI DPOUSPMMFE QPSF TJ[FT BOE BQFSUVSFT BOE BU UIF TBNF UJNF IJHI NFDIBOJD TUBCJMJUZ Å *O UIF DPVSTF PG UIFJS XPSL UIF FOHJOFFST BMTP DBNF VQ XJUI B QSPDFTTJOH DIBJO GPS TUJGG GPBNT NBEF GSPN 5J BOE /J 5J OBOP QBSUJDMFT JO BO PYZHFO GSFF BUNPTQIFSF Ä 5IF PYZHFO DPOUFOU PG MFTT UIBO NBTT QFSDFOU JO ESZ QPSPVT NBUFSJBM BOE UIF BWFSBHF QPSF TJ[F PG MFTT UIBO ñN MPPL WFSZ QSPNJTJOH Å QSPVEMZ TBZT UIF &5) ;VSJDI SFTFBSDIFS 5P CSJOH UIF QBUFOUFE SFTVMUT UP NBSLFU 6ST (PO[FOCBDI DP JOWFOUPS PG UIF UFDIOPMPHZ FTUBCMJTIFE IJT PXO DPNQBOZ XJUI UIF IFMQ PG IJT DPMMFBHVFT BO &5) TQJO PGG EF $BWJT "( #BTFE PO UIF &5) ;VSJDI QMBUGPSN EF $BWJT "( EFWFMPQT BOE NBSLFUT JOPSHBOJD QPSPVT NBUFSJBMT TVJUBCMF XIFSFWFS UIFSF JT B EFNBOE GPS TBWJOH IFBU MPTT BOE DPTU DVUUJOH "SFBT PG

BQQMJDBUJPO BSF JOEVTUSJBM QMBOUT BOE GVSOBDFT XIFSF UIF UFNQFSBUVSF FYDFFET k$ 0OF PG IJT USVNQ DBSET JT UIF DPOUSPMMFE GPSNBUJPO PG XFU GPBNT BOE FNVMTJPOT XJUI EJGGFSFOU DPNQPTJUJPOT BOE NJDSP TUSVDUVSFT Ä "T UIF GPBNT BOE FNVMTJPOT TIPX IJHI TUBCJMJUZ JO UIFJS XFU TUBUF XF DBO QSPDFTT UIFN UP QPSPVT GJCSF GSFF NBUFSJBMT PS TPMJE DPBUFE NJDSP DBQTVMFT XJUI QBSUJDVMBS DIBSBDUFSJTUJDT Å FYQMBJOT 6ST (PO[FOCBDI )F TFFT BQQMJDBUJPOT BT UIFSNBM JOTVMBUJPO BOE MJHIU XFJHIU DPOTUSVDUJPO NBUFSJBMT CVU BMTP BT NJDSP DBQTVMFT XJUI B TQFDJBM TUSVDUVSF GPS UIF FODBQTVMBUJPO BOE SFMFBTF PG DIFNJDBM DPNQPOFOUT GPS JOTUBODF JO DPTNFUJDT BOE CJP NFEJDJOF BOE DBUBMZTJT 5IF NJDSP DBQTVMFT DBO CF NBEF GSPN EJGGFSFOU SBX NBUFSJBMT BOE DVTUPNJ[FE CZ TJ[F BOE QFSNFBCJMJUZ Ä *OPSHBOJD TPMJE DPBUFE NJDSP DBQTVMFT BSF NPSF BEWBOUBHFPVT UIBO QPMZNFS BOE UFOTJMF CBTFE TZTUFNT CFDBVTF PG UIFJS WFSZ HPPE DIFNJDBM BOE IFBU TUBCJMJUZ Å UIF ZPVOH FOUSFQSFOFVS FYQMBJOT 8JUI UIFJS TNBSU GVODUJPOBM GPBNT JOWFOUFE BU &5) ;VSJDI BOE GVSUIFS EFWFMPQFE XJUIJO UIF $$.9 QSPHSBNNF UIF TDJFOUJTUT TFU B OFX TUBOEBSE JO UIF QSPNJTJOH EPNBJO PG NBUFSJBMT UFDIOPMPHZ

4JOUFSFE BMVNJOJVN PYJEF GPBNT XJUI QPSFT PG EJGGFSFOU TJ[FT &WFO UIPVHI UIFZ DPOTJTU PG BJS UIFZ BSF PG IJHI NFDIBOJDBM TUBCJMJUZ 1JDUVSF EF $BWJT

20 µm

4DBOOJOH FMFDUSPO NJDSPTDPQF QJDUVSF PG UIJO BMVNJOJVN PYJEF XBMMT TFQBSBUJOH FBDI TJOHMF QPSF PG UIF DFSBNJD NBUFSJBM 1JDUVSF EF $BWJT

1 cm

100 µm

Annual Activity Report 2009

23

Our little helpers : Nanoparticles as a drug carrier Functional particles in contact with biological fluids MatLife

Nanoparticles have the potential to create drugs of a new kind, as they enhance their bioavailability toward targeted diseased cells, and improve tissue penetration and distribution while minimizing side-effects. The work of Jeffrey Alan Hubbell, Professor at EPFL’s Merck Serono Chair in Drug Delivery, focuses on nanoparticles. In collaboration with EPFL Professor Melody Ann Swartz at the Laboratory for Lymphatic and Cancer Bioengineering, he has implemented a nanoparticle-based vaccine platform to produce novel immunotherapies based on materials with bio-functional and immunofunctional capabilities.

CCMX : Your novel polymer nanoparticle formulations specifically target the draining lymph nodes, the ‘filter stations’ for tissue fluid in the human body.

What is your intention ? +") "T SFDFOU TUVEJFT IBWF QSPWFO UIF CFTU XBZ UP BDIJFWF TVTUBJOFE JNNVOJUZ JT UP EFMJWFS BO BOUJHFO EJSFDUMZ UP BOUJHFO QSFTFOUJOH DFMMT UIF EFOESJUJD DFMMT %$

5IF QSPCMFN JT UIBU %$ DBO POMZ CF GPVOE JO MPX DPODFOUSBUJPOT JO QFSJQIFSBM UJTTVFT ‡ UIF UBSHFU BSFB PG WBDDJOFT ‡ VOMJLF MZNQI OPEFT *U UIVT NBLFT TFOTF UP EFMJWFS BO BOUJHFO UP %$ JO MZNQI OPEFT *O PSEFS UP BDUJWBUF %$ XF OFFE BO BEKVWBOU UIBU NBUVSFT %$ BOE JOJUJBUFT UIF TVCTFRVFOU JNNVOF SFTQPOTF "EKVWBOUT BSF WJUBM BT NPTU QSPUFJO BOE QFQUJEF BOUJHFOT EP OPU TIPX TVGGJDJFOU JNNVOPHFOJDJUZ CCMX : Did you succeed in solving the problem ? +") :FT UIBOLT UP UIF TFMG BTTFNCMZ PG QPMZNFS NBUFSJBM 1PMZ FUIZMFOF HMZDPM

1PMZ QSPQZMFOF TVMQIJEF XF PCUBJOFE

24

Annual Activity Report 2009

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

0VS DVSSFOU XPSL XJUI B UVCFSDVMPTJT BOUJHFO MPPLT SFNBSLBCMZ QSPNJTJOH

CCMX : Nanoparticles as drug carriers fuel ambitious expectations, and researchers around the globe are working eagerly on the topic. What is so special about your research at the EPFL ? +") 5IFSF JT JOEFFE B MPU PG SFTFBSDI CFJOH DBSSJFE PVU JO UIF EPNBJO PG OPWFM WBDDJOFT CVU XIBU NBLFT PVS EFWFMPQNFOU TP TQFDJBM JT UIBU PVS OBOPQBSUJDMFT BSF TNBMMFS UIBO NPTU WJSVTFT 5IJT JT UIF SFTVMU PG PVS DPPQFSBUJPO XJUI .FMPEZ " 4XBSU[ 8IJMF TIF GPDVTFT PO UIF QIZTJPMPHZ BOE

CJPMPHZ PG MZNQIBUJD WFTTFMT BOE MZNQIBUJD USBOTQPSU XF TUVEZ TFMG BTTFNCMZ BOE ESVH EFMJWFSZ JO UIF UJTTVF

CCMX : How did the international vaccine community and possible future industrial partners react towards your results ? +") *G ZPV DBO TIPX MBCPSBUPSZ EJTFBTF NPEFMT UIF JOEVTUSZ XJMM TIPX JOUFSFTU JO ZPVS EFWFMPQNFOU 8F XFSF TVDDFTTGVM JO PCUBJOJOH GVOEJOH GSPN UIF &VSPQFBO $PNNJTTJPO UP MFBE B QSPKFDU BOE IBWF BMTP CFFO BQQSPBDIFE CZ UIF #JMM .FMJOEB (BUFT 'PVOEBUJPO XIJDI TVQQPSUT VT JO UIF EPNBJO PG JOGFDUJPVT EJTFBTFT

B QSJPSJUZ BSFB PG GPDVT PG UIF GPVOEBUJPO " GPDBM QPJOU JT B UVCFSDVMPTJT WBDDJOF

CCMX : Legend has it that there are fears over unknown consequences of nanotechnology. +") .PTU JOEJWJEVBMT BSF FYQPTFE UP QBSUJDMFT JO UIF BNCJFOU BUNPTQIFSF FTQFDJBMMZ GSPN EJFTFM GVNFT "OZ DPNCVT UJPO QSPDFTT QSPEVDFT OBOPQBSUJDMFT #VU OBOPQBSUJDMFT EFTJHOFE UP CF CJPDPN QBUJCMF BOE QSPEVDFE JO B SFTQPOTJCMF XBZ PQFO VQ GBOUBTUJD QPTTJCJMJUJFT GPS JNQSPWJOH IVNBO IFBMUI BOE IFBMJOH PS QSFWFOUJOH EJTFBTFT JODVSBCMF BU UIF

QSFTFOU EBZ +VTU UIJOL PG JOGMVFO[B XIJDI TQSFBET BSPVOE UIF XPSME JO TFBTPOBM FQJEFNJDT DPTUJOH UIF MJWFT PG VQ UP IBMG B NJMMJPO QFPQMF FBDI ZFBS "T GMV FWPMWFT TP SBQJEMZ B WBDDJOF GPSNVMBUFE POF ZFBS DBO CF JOFGGFDUJWF UIF OFYU ZFBS )FSF XF OFFE CFUUFS BOE GBTUFS NFUIPET GPS EFWFMPQJOH OFX BDUJWF BHFOUT PO B DIFNJDBM CBTJT *U JT BMTP XPSUI SFNFNCFSJOH UIBU UPEBZŠT CJPMPHJDBM WBDDJOFT NVTU CF TUPSFE BU MPX UFNQFSBUVSFT XIJDI JT QSPCMFNBUJD JO EFWFMPQJOH DPVOUSJFT 8JUI PVS BQQSPBDI UIF WBDDJOFT BSF TUBCMF BOE SFGSJHFSBUPST NBZ OP MPOHFS CF OFFEFE

Annual Activity Report 2009

25

Our little helpers : Nanoparticles as a drug carrier Functional particles in contact with biological fluids MatLife

Nanoparticles have the potential to create drugs of a new kind, as they enhance their bioavailability toward targeted diseased cells, and improve tissue penetration and distribution while minimizing side-effects. The work of Jeffrey Alan Hubbell, Professor at EPFL’s Merck Serono Chair in Drug Delivery, focuses on nanoparticles. In collaboration with EPFL Professor Melody Ann Swartz at the Laboratory for Lymphatic and Cancer Bioengineering, he has implemented a nanoparticle-based vaccine platform to produce novel immunotherapies based on materials with bio-functional and immunofunctional capabilities.

CCMX : Your novel polymer nanoparticle formulations specifically target the draining lymph nodes, the ‘filter stations’ for tissue fluid in the human body.

What is your intention ? +") "T SFDFOU TUVEJFT IBWF QSPWFO UIF CFTU XBZ UP BDIJFWF TVTUBJOFE JNNVOJUZ JT UP EFMJWFS BO BOUJHFO EJSFDUMZ UP BOUJHFO QSFTFOUJOH DFMMT UIF EFOESJUJD DFMMT %$

5IF QSPCMFN JT UIBU %$ DBO POMZ CF GPVOE JO MPX DPODFOUSBUJPOT JO QFSJQIFSBM UJTTVFT ‡ UIF UBSHFU BSFB PG WBDDJOFT ‡ VOMJLF MZNQI OPEFT *U UIVT NBLFT TFOTF UP EFMJWFS BO BOUJHFO UP %$ JO MZNQI OPEFT *O PSEFS UP BDUJWBUF %$ XF OFFE BO BEKVWBOU UIBU NBUVSFT %$ BOE JOJUJBUFT UIF TVCTFRVFOU JNNVOF SFTQPOTF "EKVWBOUT BSF WJUBM BT NPTU QSPUFJO BOE QFQUJEF BOUJHFOT EP OPU TIPX TVGGJDJFOU JNNVOPHFOJDJUZ CCMX : Did you succeed in solving the problem ? +") :FT UIBOLT UP UIF TFMG BTTFNCMZ PG QPMZNFS NBUFSJBM 1PMZ FUIZMFOF HMZDPM

1PMZ QSPQZMFOF TVMQIJEF XF PCUBJOFE

24

Annual Activity Report 2009

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

0VS DVSSFOU XPSL XJUI B UVCFSDVMPTJT BOUJHFO MPPLT SFNBSLBCMZ QSPNJTJOH

CCMX : Nanoparticles as drug carriers fuel ambitious expectations, and researchers around the globe are working eagerly on the topic. What is so special about your research at the EPFL ? +") 5IFSF JT JOEFFE B MPU PG SFTFBSDI CFJOH DBSSJFE PVU JO UIF EPNBJO PG OPWFM WBDDJOFT CVU XIBU NBLFT PVS EFWFMPQNFOU TP TQFDJBM JT UIBU PVS OBOPQBSUJDMFT BSF TNBMMFS UIBO NPTU WJSVTFT 5IJT JT UIF SFTVMU PG PVS DPPQFSBUJPO XJUI .FMPEZ " 4XBSU[ 8IJMF TIF GPDVTFT PO UIF QIZTJPMPHZ BOE

CJPMPHZ PG MZNQIBUJD WFTTFMT BOE MZNQIBUJD USBOTQPSU XF TUVEZ TFMG BTTFNCMZ BOE ESVH EFMJWFSZ JO UIF UJTTVF

CCMX : How did the international vaccine community and possible future industrial partners react towards your results ? +") *G ZPV DBO TIPX MBCPSBUPSZ EJTFBTF NPEFMT UIF JOEVTUSZ XJMM TIPX JOUFSFTU JO ZPVS EFWFMPQNFOU 8F XFSF TVDDFTTGVM JO PCUBJOJOH GVOEJOH GSPN UIF &VSPQFBO $PNNJTTJPO UP MFBE B QSPKFDU BOE IBWF BMTP CFFO BQQSPBDIFE CZ UIF #JMM .FMJOEB (BUFT 'PVOEBUJPO XIJDI TVQQPSUT VT JO UIF EPNBJO PG JOGFDUJPVT EJTFBTFT

B QSJPSJUZ BSFB PG GPDVT PG UIF GPVOEBUJPO " GPDBM QPJOU JT B UVCFSDVMPTJT WBDDJOF

CCMX : Legend has it that there are fears over unknown consequences of nanotechnology. +") .PTU JOEJWJEVBMT BSF FYQPTFE UP QBSUJDMFT JO UIF BNCJFOU BUNPTQIFSF FTQFDJBMMZ GSPN EJFTFM GVNFT "OZ DPNCVT UJPO QSPDFTT QSPEVDFT OBOPQBSUJDMFT #VU OBOPQBSUJDMFT EFTJHOFE UP CF CJPDPN QBUJCMF BOE QSPEVDFE JO B SFTQPOTJCMF XBZ PQFO VQ GBOUBTUJD QPTTJCJMJUJFT GPS JNQSPWJOH IVNBO IFBMUI BOE IFBMJOH PS QSFWFOUJOH EJTFBTFT JODVSBCMF BU UIF

QSFTFOU EBZ +VTU UIJOL PG JOGMVFO[B XIJDI TQSFBET BSPVOE UIF XPSME JO TFBTPOBM FQJEFNJDT DPTUJOH UIF MJWFT PG VQ UP IBMG B NJMMJPO QFPQMF FBDI ZFBS "T GMV FWPMWFT TP SBQJEMZ B WBDDJOF GPSNVMBUFE POF ZFBS DBO CF JOFGGFDUJWF UIF OFYU ZFBS )FSF XF OFFE CFUUFS BOE GBTUFS NFUIPET GPS EFWFMPQJOH OFX BDUJWF BHFOUT PO B DIFNJDBM CBTJT *U JT BMTP XPSUI SFNFNCFSJOH UIBU UPEBZŠT CJPMPHJDBM WBDDJOFT NVTU CF TUPSFE BU MPX UFNQFSBUVSFT XIJDI JT QSPCMFNBUJD JO EFWFMPQJOH DPVOUSJFT 8JUI PVS BQQSPBDI UIF WBDDJOFT BSF TUBCMF BOE SFGSJHFSBUPST NBZ OP MPOHFS CF OFFEFE

Annual Activity Report 2009

25

New healing opportunities foreseen with innovative cellsheet engineering Medical device technology and innovation MatLife

The aim to repair or replace lost or damaged tissue and organs by creating living, functional substitutes from autologous cells stimulates researchers all over the world. A promising clinical methodology to reconstruct tissues for transplantation is cell sheet engineering.

'PS UIJT QVSQPTF DVMUVSF TVSGBDFT BSF HSBGUFE XJUI UFNQFSBUVSF SFTQPOTJWF QPMZNFS UIBU NBLFT JU QPTTJCMF UP BUUBDI BOE EFUBDI MJWJOH DFMMT JO B DPOUSPMMFE XBZ WJB TJNQMF UFNQFSBUVSF DIBOHFT GSPN k$ UP CFMPX k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¨S¨T GSPN UIF *OTUJUVUF GPS #JPNFEJDBM &OHJOFFSJOH PG &5) ;VSJDI 5IFZ EFWFMPQ % EFTJHOFE DPNQPTJUF NBUFSJBMT DPOTJTUJOH PG DFMM TIFFUT BOE QPMZNFS IZESPHFM GJMNT 5IF % DFMM QPMZNFS NVMUJMBZFST TFSWF BT B QMBUGPSN UP TQBUJBMMZ QBUUFSO EJGGFSFOU DFMM UZQFT GPS JO WJUSP BOBMZTJT BOE GPS ESVH TDSFFOJOH Ä5IF GBTDJOBUJOH OPWFMUZ JO UIJT QSPKFDU JT UIF JOUFSEJTDJQMJOBSZ BQQSPBDIÅ TUBUFT 1I% TUVEFOU 0SBOF (VJMMBVNF (FOUJM Ä8IJMF PVS TUSPOH QPJOU JT DFMM TIFFU UFDIOPMPHZ UIF PCTUFUSJDJBOT PG 6OJWFSTJUZ )PTQJUBM ;VSJDI DPOUSJCVUF CZ QSPWJEJOH UIFJS LOPX IPX JO IVNBO TUFN QSPHFOJUPS DFMM CJPMPHZ JO % DVMUVSF BOE UIF %FQBSU NFOU PG $SBOJP .BYJMMPGBDJBM 4VSHFSZ GPDVTFT PO UJTTVF FOHJOFFSJOH PG CPOF BOE DBSUJMBHF BOE JT TQFDJBMJ[FE PO JO TJUV UJTTVF FOHJOFFSJOH CZ VTJOH OFXMZ EFWFMPQFE TZOUIFUJD BOE CJPNJNFUJD NBUFSJBMT Å

26

Annual Activity Report 2009

5IF JOOPWBUJWF BQQSPBDI PG UIF &5) ;VSJDI TDJFOUJTUT JT UP IBSWFTU UIF DFMM TIFFUT CZ FMFDUSPDIFNJDBM NFBOT 5IJT QSPDFEVSF DPNCJOFE XJUI NJDSP QBUUFSOJOH UFDIOJRVFT BMMPXT UIF DPOUSPM PG UIF TQBUJBM PSHBOJ[BUJPO PG UIF DFMMT JO % Ä8F EFWFMPQ B % DPNQP TJUF NBUFSJBM DPOTJTUJOH PG BMUFSOBUJOH MBZFST PG % FOHJOFFSFE IFUFSPUZQJD DFMM TIFFUT BOE NJDSP TUSVDUVSFE CJPEFHSBEBCMF QPMZ NFSJD IZESPHFMT DPOUBJOJOH DFMMT QSPUFJOT BOE HSPXUI GBDUPSTÅ FYQMBJOT UIF DFMM TIFFU TQFDJBMJTU Å 5IF NBJO BDIJFWFNFOU PG UIF $$.9 QSPKFDU JT UIF EFWFMPQNFOU PG UIF QSPDFEVSF UP UBJMPS UIF EJTTPMVUJPO TQFFE VTJOH DSPTT MJOLFE DPBUJOHT 3JHIU BU UIF TUBSU UIF QPMZNFS NVMUJMBZFS GJMNT XFSF UPP TPGU GPS BODIPSJOH UIF NFTFODIZNBM TUFN DFMMT PO UIF TVSGBDF 5IBOLT UP UIF DSPTT MJOLJOH QPMZNFS UIF TDJFOUJTUT JODSFBTFE UIF TUJGGOFTT XIJDI TVQQPSUT UIF TUBCMF BEIFTJPO PG UIF NFTFODIZNBM TUFN DFMMT B QSFSFRVJTJUF GPS UIF QSFQBSBUJPO PG WJBCMF DFMM TIFFUT Ä 8F BSF OPX JO B QPTJUJPO UP QSPEVDF UIJDLFS UJTTVFT UIBOLT UP NPSF VOJGPSN PYZHFO BOE OVUSJUJPO TVQQMZ UP UIF DFMMT JOTJEF UIF NBUFSJBMT UISPVHI FOHJOFFSFE QPSPTJUJFT BOE UP PCUBJO B QMBUGPSN GPS DFMM TIFFU FOHJOFFSJOH XJUI FMFDUSPOJDBMMZ TXJUDIBCMF NJDSP TUSVDUVSFE TVSGBDFT Å 8JUI UIJT QMBUGPSN UIF SFTFBSDIFST DBO UVOF UIF NFDIBOJDBM QSPQFSUJFT PG UIF DPNQPTJUF NBUFSJBM CZ TFMFDUJOH UIF QPMZNFS MBZFST BOE QSPDFTTJOH JU FBTJMZ JOUP EJGGFSFOU TIBQFT BOE TJ[FT #BTFE PO UIFTF SFTVMUT JU XBT QPTTJCMF UP FTUBCMJTI PQUJNBM DFMM EFOTJUZ BOE DFMM DVMUVSF UJNF BOE TVDDFTTGVMMZ IBSWFTU TUFN DFMM TIFFUT

Ä 5IF DIBMMFOHF JT UP QSPWJEF UIF DFMMT XJUI B GFFM HPPE BNCJBODF UP HSPX UIBU JT UP TBZ UIF TBNF DPOEJUJPOT BT UIFZ XJMM GJOE JO UIFJS GVUVSF FOWJSPONFOU BGUFS UIFZ BSF HSBGUFE Å 6TJOH UIF OFX NFUIPE EFWFMPQFE BU &5) ;VSJDI DFMMT BSF PSHBOJTFE JO B XFMM EFGJOFE NVMUJMBZFSFE

% FOWJSPONFOU PG EFTJHOFE QPMZNFS TVCTUSBUFT QSFTFOUJOH TQFDJGJD BOE WBSJBCMF DVFT GPS DFMM HSPXUI Ä 3FHFOFSBUJWF NFEJDJOF IBT UIF QPUFOUJBM UP PQFO VQ IFBMJOH PQQPSUVOJUJFT UIBU XFSF VOJNBHJOBCMF VQ UP OPX Å TUBUFT

0SBOF (VJMMBVNF (FOUJM Ä #VU UP NBLF UIF OFDFTTBSZ UFDIOPMPHZ UBLF PGG XF IBWF UP MFBWF UIF CFBUFO USBDL MJOL EJGGFSFOU TDJFOUJGJD EPNBJOT BOE FYQMPJU TZOFSHJFT BT UIF SFBMMZ JOOPWBUJWF OFX UIJOHT FNFSHF BU UIF JOUFSGBDF PG EJTDJQMJOFT Å 5IF JOUFSOBUJPOBM SFTFBSDI DPNNVOJUZ JT

DMPTFMZ GPMMPXJOH UIF 4XJTT BDUJWJUJFT JO UIJT EPNBJO QBSU PG UIJT XPSL XBT BXBSEFE UIF CFTU BCTUSBDU QSJ[F BU 5&3.*4 &6 UIF &VSPQFBO TFDUJPO PG UIF 5JTTVF &OHJOFFSJOH 3FHFOFSBUJWF .FEJDJOF 4PDJFUZ BOE UIF QSPKFDU SFTVMUT XFSF QVCMJTIFE JO UIF SFOPXOFE 5JTTVF &OHJOFFSJOH +PVSOBM

Annual Activity Report 2009

27

New healing opportunities foreseen with innovative cellsheet engineering Medical device technology and innovation MatLife

The aim to repair or replace lost or damaged tissue and organs by creating living, functional substitutes from autologous cells stimulates researchers all over the world. A promising clinical methodology to reconstruct tissues for transplantation is cell sheet engineering.

'PS UIJT QVSQPTF DVMUVSF TVSGBDFT BSF HSBGUFE XJUI UFNQFSBUVSF SFTQPOTJWF QPMZNFS UIBU NBLFT JU QPTTJCMF UP BUUBDI BOE EFUBDI MJWJOH DFMMT JO B DPOUSPMMFE XBZ WJB TJNQMF UFNQFSBUVSF DIBOHFT GSPN k$ UP CFMPX k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¨S¨T GSPN UIF *OTUJUVUF GPS #JPNFEJDBM &OHJOFFSJOH PG &5) ;VSJDI 5IFZ EFWFMPQ % EFTJHOFE DPNQPTJUF NBUFSJBMT DPOTJTUJOH PG DFMM TIFFUT BOE QPMZNFS IZESPHFM GJMNT 5IF % DFMM QPMZNFS NVMUJMBZFST TFSWF BT B QMBUGPSN UP TQBUJBMMZ QBUUFSO EJGGFSFOU DFMM UZQFT GPS JO WJUSP BOBMZTJT BOE GPS ESVH TDSFFOJOH Ä5IF GBTDJOBUJOH OPWFMUZ JO UIJT QSPKFDU JT UIF JOUFSEJTDJQMJOBSZ BQQSPBDIÅ TUBUFT 1I% TUVEFOU 0SBOF (VJMMBVNF (FOUJM Ä8IJMF PVS TUSPOH QPJOU JT DFMM TIFFU UFDIOPMPHZ UIF PCTUFUSJDJBOT PG 6OJWFSTJUZ )PTQJUBM ;VSJDI DPOUSJCVUF CZ QSPWJEJOH UIFJS LOPX IPX JO IVNBO TUFN QSPHFOJUPS DFMM CJPMPHZ JO % DVMUVSF BOE UIF %FQBSU NFOU PG $SBOJP .BYJMMPGBDJBM 4VSHFSZ GPDVTFT PO UJTTVF FOHJOFFSJOH PG CPOF BOE DBSUJMBHF BOE JT TQFDJBMJ[FE PO JO TJUV UJTTVF FOHJOFFSJOH CZ VTJOH OFXMZ EFWFMPQFE TZOUIFUJD BOE CJPNJNFUJD NBUFSJBMT Å

26

Annual Activity Report 2009

5IF JOOPWBUJWF BQQSPBDI PG UIF &5) ;VSJDI TDJFOUJTUT JT UP IBSWFTU UIF DFMM TIFFUT CZ FMFDUSPDIFNJDBM NFBOT 5IJT QSPDFEVSF DPNCJOFE XJUI NJDSP QBUUFSOJOH UFDIOJRVFT BMMPXT UIF DPOUSPM PG UIF TQBUJBM PSHBOJ[BUJPO PG UIF DFMMT JO % Ä8F EFWFMPQ B % DPNQP TJUF NBUFSJBM DPOTJTUJOH PG BMUFSOBUJOH MBZFST PG % FOHJOFFSFE IFUFSPUZQJD DFMM TIFFUT BOE NJDSP TUSVDUVSFE CJPEFHSBEBCMF QPMZ NFSJD IZESPHFMT DPOUBJOJOH DFMMT QSPUFJOT BOE HSPXUI GBDUPSTÅ FYQMBJOT UIF DFMM TIFFU TQFDJBMJTU Å 5IF NBJO BDIJFWFNFOU PG UIF $$.9 QSPKFDU JT UIF EFWFMPQNFOU PG UIF QSPDFEVSF UP UBJMPS UIF EJTTPMVUJPO TQFFE VTJOH DSPTT MJOLFE DPBUJOHT 3JHIU BU UIF TUBSU UIF QPMZNFS NVMUJMBZFS GJMNT XFSF UPP TPGU GPS BODIPSJOH UIF NFTFODIZNBM TUFN DFMMT PO UIF TVSGBDF 5IBOLT UP UIF DSPTT MJOLJOH QPMZNFS UIF TDJFOUJTUT JODSFBTFE UIF TUJGGOFTT XIJDI TVQQPSUT UIF TUBCMF BEIFTJPO PG UIF NFTFODIZNBM TUFN DFMMT B QSFSFRVJTJUF GPS UIF QSFQBSBUJPO PG WJBCMF DFMM TIFFUT Ä 8F BSF OPX JO B QPTJUJPO UP QSPEVDF UIJDLFS UJTTVFT UIBOLT UP NPSF VOJGPSN PYZHFO BOE OVUSJUJPO TVQQMZ UP UIF DFMMT JOTJEF UIF NBUFSJBMT UISPVHI FOHJOFFSFE QPSPTJUJFT BOE UP PCUBJO B QMBUGPSN GPS DFMM TIFFU FOHJOFFSJOH XJUI FMFDUSPOJDBMMZ TXJUDIBCMF NJDSP TUSVDUVSFE TVSGBDFT Å 8JUI UIJT QMBUGPSN UIF SFTFBSDIFST DBO UVOF UIF NFDIBOJDBM QSPQFSUJFT PG UIF DPNQPTJUF NBUFSJBM CZ TFMFDUJOH UIF QPMZNFS MBZFST BOE QSPDFTTJOH JU FBTJMZ JOUP EJGGFSFOU TIBQFT BOE TJ[FT #BTFE PO UIFTF SFTVMUT JU XBT QPTTJCMF UP FTUBCMJTI PQUJNBM DFMM EFOTJUZ BOE DFMM DVMUVSF UJNF BOE TVDDFTTGVMMZ IBSWFTU TUFN DFMM TIFFUT

Ä 5IF DIBMMFOHF JT UP QSPWJEF UIF DFMMT XJUI B GFFM HPPE BNCJBODF UP HSPX UIBU JT UP TBZ UIF TBNF DPOEJUJPOT BT UIFZ XJMM GJOE JO UIFJS GVUVSF FOWJSPONFOU BGUFS UIFZ BSF HSBGUFE Å 6TJOH UIF OFX NFUIPE EFWFMPQFE BU &5) ;VSJDI DFMMT BSF PSHBOJTFE JO B XFMM EFGJOFE NVMUJMBZFSFE

% FOWJSPONFOU PG EFTJHOFE QPMZNFS TVCTUSBUFT QSFTFOUJOH TQFDJGJD BOE WBSJBCMF DVFT GPS DFMM HSPXUI Ä 3FHFOFSBUJWF NFEJDJOF IBT UIF QPUFOUJBM UP PQFO VQ IFBMJOH PQQPSUVOJUJFT UIBU XFSF VOJNBHJOBCMF VQ UP OPX Å TUBUFT

0SBOF (VJMMBVNF (FOUJM Ä #VU UP NBLF UIF OFDFTTBSZ UFDIOPMPHZ UBLF PGG XF IBWF UP MFBWF UIF CFBUFO USBDL MJOL EJGGFSFOU TDJFOUJGJD EPNBJOT BOE FYQMPJU TZOFSHJFT BT UIF SFBMMZ JOOPWBUJWF OFX UIJOHT FNFSHF BU UIF JOUFSGBDF PG EJTDJQMJOFT Å 5IF JOUFSOBUJPOBM SFTFBSDI DPNNVOJUZ JT

DMPTFMZ GPMMPXJOH UIF 4XJTT BDUJWJUJFT JO UIJT EPNBJO QBSU PG UIJT XPSL XBT BXBSEFE UIF CFTU BCTUSBDU QSJ[F BU 5&3.*4 &6 UIF &VSPQFBO TFDUJPO PG UIF 5JTTVF &OHJOFFSJOH 3FHFOFSBUJWF .FEJDJOF 4PDJFUZ BOE UIF QSPKFDU SFTVMUT XFSF QVCMJTIFE JO UIF SFOPXOFE 5JTTVF &OHJOFFSJOH +PVSOBM

Annual Activity Report 2009

27

How to create the perfect environment for single cells Biosensing and diagnostic strategies MatLife

For basic biological questions as well as drug screening, single cells or cells in 3D scaffolds are currently a focal interest of scientists. Cell responses are influenced by cues such as pH, temperature, growth factors and nutrients, but also through the binding to matrix components, other cells or the mechanical properties of the environment. With artificial, engineered environments, these different parameters can be independently controlled, thereby enabling the investigation of the relationship between relevant stimuli and cell response.

3FTFBSDIFST GSPN &5) ;VSJDI &NQB BOE "0 'PVOEBUJPO %BWPT XFSF KPJOFE CZ JOEVTUSJBM QBSUOFS ' )PGGNBOO -B 3PDIF -UE UP EFWFMPQ B QMBUGPSN UFDIOPMPHZ UIBU BMMPXT JOWFTUJHBUJPO PG UIF DFMM CFIBWJPVS JO TQFDJBMMZ FOHJOFFSFE % NJDSP FOWJSPO NFOUT 5IJT UFDIOPMPHZ DPOTJTUJOH PG BEIFTJWF NJDSP XFMMT XIJDI HJWFT DPOUSPM PWFS EJNFOTJPOBMJUZ BOE DFMM TIBQF XBT EFWFMPQFE B GFX ZFBST BHP CZ UIF UFBN PG 1SPGFTTPS .BSDVT 5FYUPS BU &5) ;VSJDI 6Q VOUJM SFDFOUMZ JU XBT POMZ QPTTJCMF UP FOUSBQ DFMMT JO NJDSP XFMMT GPS VQ UP IPVST BOE UIF SFMFWBODF PG UIF FYQFSJNFOUT GPS TUFN DFMM TUVEJFT XBT MJNJUFE " NBKPS UBTL PG UIF

28

Annual Activity Report 2009

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

XIJDI XBT UIFO GPMMPXFE CZ CBDLGJMMJOH UIF QMBUFBV XJUI 1MVSPOJDÈ B CMPDL DP QPMZNFS CBTFE PO FUIZMFOF PYJEF BOE QSPQZMFOF PYJEF Ä*U UPPL B XIJMF UP HFU JU XPSLJOHÅ TBZT .BSLVT 3PUUNBS 1I% TUVEFOU BU &NQB XIP JT XSJUJOH IJT UIFTJT PO UIJT UPQJD "MTP UP TUVEZ UIF DFMMT JO UIFJS % FOWJSPO NFOU UIF TDJFOUJTUT JOUSPEVDFE HFOFT JOUP UIF DFMMT XIJDI DPEF GPS TQFDJGJD QSPUFJOT PG JOUFSFTU GVTFE UP GMVPSFTDFOU QSPUFJOT 5IF GMVPSFTDFODF DBO UIFO CF GPMMPXFE JO UIF MJWJOH DFMMT JO SFBM UJNF GPS TFWFSBM EBZT UP EFUFSNJOF GPS JOTUBODF IPX UIF DFMM BSDIJUFDUVSF DIBOHFT JO UIF DPVSTF PG UIF

DVMUJWBUJPO Ä#VU UIF TUBUJTUJDBM FWBMVBUJPO PG UIF FYQFSJNFOUT SFRVJSFT B HSFBU OVNCFS PG QJDUVSFT PG TJOHMF DFMMT XIJDI MFBET UP BO FOPSNPVT BNPVOU PG EBUB BOE DPNQMJ DBUFT UIF BOBMZTJT XJUI DPOWFOUJPOBM TPGU XBSF BOE BMHPSJUINTÅ FYQMBJOT UIF ZPVOH TDJFOUJTU XIP VTFE UP XPSL BU UIF *OTUJUVUF PG .PMFDVMBS 4ZTUFNT #JPMPHZ BU &5) ;VSJDI Ä'PS NZ EJQMPNB UIFTJT * IBE UIF PQQPSUVOJUZ UP XPSL PO B CBTJD SFTFBSDI TVCKFDU JO UIF GJFME PG CBDUFSJBM QIZTJPMPHZ #VU GPS NZ EJTTFSUBUJPO * MPPLFE GPS B OFX DIBMMFOHF BOE XBT JNNFEJBUFMZ JOUFSFTUFE JO UIF JOUFSEJTDJQMJOBSZ QSPCMFN BSFB PG UIJT QSPKFDU Å

" TQFDJGJD BQQMJDBUJPO PG UIF NJDSP XFMM BSSBZT DPVME CF UIF TUVEZ PG BOUJ DBODFS ESVHT PO DBODFS DFMM DMVTUFST HSPXO JO B % FOWJSPONFOU 5IF BSSBZFE GPSNBU PG UIF NJDSP XFMMT FOTVSFT UIBU UIJT QMBUGPSN JT TVJUBCMF GPS BO BVUPNBUFE JNBHJOH NBLJOH JU BQQSPQSJBUF GPS IJHI UISPVHIQVU TDSFFOJOH *U BMTP PGGFST UIF BEWBOUBHF PG B DPOUSPMMFE % FOWJSPONFOU JO XIJDI EJGGFSFOU FYUSJOTJD QBSBNFUFST DBO CF WBSJFE JOEFQFOEFOUMZ 5IFSFXJUI JU JT B QSPNJTJOH UPPM GPS UIF PCTFSWBUJPO BOE RVBOUJGJDBUJPO PG CJPMPHJDBM QIFOPNFOB JO IJHIMZ DPOUSPMMFE % FOWJSPONFOUT ' )PGGNBOO -B 3PDIF TIPXT HSFBU

JOUFSFTU JO UIF $$.9 QSPKFDU SFTVMUT Ä5IF NJDSP XFMM QMBUGPSN DPVME CF FYQMPJUFE GPS GVOEBNFOUBM CJPMPHJDBM TUVEJFT BT XFMM BT DFMM CBTFE BTTBZ GPS ESVH EFWFMPQNFOU BOE TDSFFOJOHÅ DPNNFOUT .BSLVT 3PUUNBS XIP JT NPWJOH BIFBE TUFQ CZ TUFQ *O /PWFNCFS IF QVCMJTIFE B QBQFS JO UIF +PVSOBM PG .BUFSJBM 4DJFODF .BUFSJBMT JO .FEJDJOF PO 4UFN DFMM QMBTUJDJUZ PTUFPHFOJD EJGGFSFOUJBUJPO BOE UIF UIJSE EJNFOTJPO UPHFUIFS XJUI &5) ;VSJDI TDJFOUJTUT BOE .JDIBFM 4NJUI UPEBZ BU UIF %FQBSUNFOU PG #JPNFEJDBM &OHJOFFSJOH BU UIF #PTUPO 6OJWFSTJUZ XJUI XIPN IF LFFQT JO UPVDI

Annual Activity Report 2009

29

How to create the perfect environment for single cells Biosensing and diagnostic strategies MatLife

For basic biological questions as well as drug screening, single cells or cells in 3D scaffolds are currently a focal interest of scientists. Cell responses are influenced by cues such as pH, temperature, growth factors and nutrients, but also through the binding to matrix components, other cells or the mechanical properties of the environment. With artificial, engineered environments, these different parameters can be independently controlled, thereby enabling the investigation of the relationship between relevant stimuli and cell response.

3FTFBSDIFST GSPN &5) ;VSJDI &NQB BOE "0 'PVOEBUJPO %BWPT XFSF KPJOFE CZ JOEVTUSJBM QBSUOFS ' )PGGNBOO -B 3PDIF -UE UP EFWFMPQ B QMBUGPSN UFDIOPMPHZ UIBU BMMPXT JOWFTUJHBUJPO PG UIF DFMM CFIBWJPVS JO TQFDJBMMZ FOHJOFFSFE % NJDSP FOWJSPO NFOUT 5IJT UFDIOPMPHZ DPOTJTUJOH PG BEIFTJWF NJDSP XFMMT XIJDI HJWFT DPOUSPM PWFS EJNFOTJPOBMJUZ BOE DFMM TIBQF XBT EFWFMPQFE B GFX ZFBST BHP CZ UIF UFBN PG 1SPGFTTPS .BSDVT 5FYUPS BU &5) ;VSJDI 6Q VOUJM SFDFOUMZ JU XBT POMZ QPTTJCMF UP FOUSBQ DFMMT JO NJDSP XFMMT GPS VQ UP IPVST BOE UIF SFMFWBODF PG UIF FYQFSJNFOUT GPS TUFN DFMM TUVEJFT XBT MJNJUFE " NBKPS UBTL PG UIF

28

Annual Activity Report 2009

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

XIJDI XBT UIFO GPMMPXFE CZ CBDLGJMMJOH UIF QMBUFBV XJUI 1MVSPOJDÈ B CMPDL DP QPMZNFS CBTFE PO FUIZMFOF PYJEF BOE QSPQZMFOF PYJEF Ä*U UPPL B XIJMF UP HFU JU XPSLJOHÅ TBZT .BSLVT 3PUUNBS 1I% TUVEFOU BU &NQB XIP JT XSJUJOH IJT UIFTJT PO UIJT UPQJD "MTP UP TUVEZ UIF DFMMT JO UIFJS % FOWJSPO NFOU UIF TDJFOUJTUT JOUSPEVDFE HFOFT JOUP UIF DFMMT XIJDI DPEF GPS TQFDJGJD QSPUFJOT PG JOUFSFTU GVTFE UP GMVPSFTDFOU QSPUFJOT 5IF GMVPSFTDFODF DBO UIFO CF GPMMPXFE JO UIF MJWJOH DFMMT JO SFBM UJNF GPS TFWFSBM EBZT UP EFUFSNJOF GPS JOTUBODF IPX UIF DFMM BSDIJUFDUVSF DIBOHFT JO UIF DPVSTF PG UIF

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JOUFSFTU JO UIF $$.9 QSPKFDU SFTVMUT Ä5IF NJDSP XFMM QMBUGPSN DPVME CF FYQMPJUFE GPS GVOEBNFOUBM CJPMPHJDBM TUVEJFT BT XFMM BT DFMM CBTFE BTTBZ GPS ESVH EFWFMPQNFOU BOE TDSFFOJOHÅ DPNNFOUT .BSLVT 3PUUNBS XIP JT NPWJOH BIFBE TUFQ CZ TUFQ *O /PWFNCFS IF QVCMJTIFE B QBQFS JO UIF +PVSOBM PG .BUFSJBM 4DJFODF .BUFSJBMT JO .FEJDJOF PO 4UFN DFMM QMBTUJDJUZ PTUFPHFOJD EJGGFSFOUJBUJPO BOE UIF UIJSE EJNFOTJPO UPHFUIFS XJUI &5) ;VSJDI TDJFOUJTUT BOE .JDIBFM 4NJUI UPEBZ BU UIF %FQBSUNFOU PG #JPNFEJDBM &OHJOFFSJOH BU UIF #PTUPO 6OJWFSTJUZ XJUI XIPN IF LFFQT JO UPVDI

Annual Activity Report 2009

29

Materials for micro- and nano systems The Lab-on-a-chip – a reliable way to detect antibodies in a substance MMNS

“What a huge relief! The whole technical team is delighted that it works so well.” The ‘thing’ Norman Wainwright of the Charles River Laboratories was so happy about on this spring day of 2007 was a miniature biological laboratory tested for the first time onboard the International Space Station. The Lab-on-a-Chip detected the presence of bacteria or fungi on the surfaces of a spacecraft far more rapidly than standard methods of culturing.

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30

Annual Activity Report 2009

PG HFOFT -BC PO B $IJQ 5FDIOPMPHZ IFMQT UP DPOUSPM GPPE RVBMJUZ UP NPOJUPS FOWJSPONFOU QBSBNFUFST BOE NFEJDBM EFWJDFT GPS JOTUBODF SFHBSEJOH UIF BVUPNBUJD JOTVMJO TVQQMZ "O JOOPWBUJWF BQQSPBDI UP -BC PO B $IJQ UFDIOPMPHZ XBT DIPTFO CZ B UFBN PG TDJFOUJTUT VOEFS UIF BFHJT PG 1SPGFTTPS .BSUJO (JKT PG UIF &1'- .JDSPTZTUFNT -BCPSBUPSZ 5IF

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Annual Activity Report 2009

31

Materials for micro- and nano systems The Lab-on-a-chip – a reliable way to detect antibodies in a substance MMNS

“What a huge relief! The whole technical team is delighted that it works so well.” The ‘thing’ Norman Wainwright of the Charles River Laboratories was so happy about on this spring day of 2007 was a miniature biological laboratory tested for the first time onboard the International Space Station. The Lab-on-a-Chip detected the presence of bacteria or fungi on the surfaces of a spacecraft far more rapidly than standard methods of culturing.

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30

Annual Activity Report 2009

PG HFOFT -BC PO B $IJQ 5FDIOPMPHZ IFMQT UP DPOUSPM GPPE RVBMJUZ UP NPOJUPS FOWJSPONFOU QBSBNFUFST BOE NFEJDBM EFWJDFT GPS JOTUBODF SFHBSEJOH UIF BVUPNBUJD JOTVMJO TVQQMZ "O JOOPWBUJWF BQQSPBDI UP -BC PO B $IJQ UFDIOPMPHZ XBT DIPTFO CZ B UFBN PG TDJFOUJTUT VOEFS UIF BFHJT PG 1SPGFTTPS .BSUJO (JKT PG UIF &1'- .JDSPTZTUFNT -BCPSBUPSZ 5IF

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Annual Activity Report 2009

31

2009 Data

2009 Peer reviewed publications

Use of funding in 2009 (KCHF)

Metrics for 2009

Funding of projects

4’188

Education activities, conferences

183

Industrial liaison

180

Management & administration

449

Total

5’000

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Annual Activity Report 2009

33

2009 Data

2009 Peer reviewed publications

Use of funding in 2009 (KCHF)

Metrics for 2009

Funding of projects

4’188

Education activities, conferences

183

Industrial liaison

180

Management & administration

449

Total

5’000

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32

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Annual Activity Report 2009

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Annual Activity Report 2009

33

Projects funded in 2009

2009 Peer reviewed publications " # 1IJMMJPO + - %FTCJPMMFT . 3BQQB[

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PI’s Institution

Others Institutions

ERU/ Platform

Philippe Renaud

EPFL

EPFL (2), PSI

SPERU

Jennifer Rupp

ETH Zurich

ETH Zurich, Empa, PSI (2)

SPERU

4NBSU GVODUJPOBM GPBNT

Ludwig Gauckler

ETH Zurich

EPFL, ETH Zurich (2)

SPERU

;FSP PSEFS OBOP PQUJDBM QJHNFOUT ;0/01

Alexander Stuck

CSEM

EPFL

SPERU

Christian Hinderling & Matha Liley

CSEM

ETH Zurich (2)

MatLife

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Jeffrey Hubbell

EPFL

EPFL, ETH Zurich

MatLife

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Peter Seeberger

ETH Zurich

ETH Zurich

MatLife

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Samuele Tosatti

ETH Zurich

ETH Zurich (4), Empa

MatLife

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. 4UBNQBOPOJ $POOFDUJWJUZ PG 1IBTFT BOE

& .JMZVUJO BOE 1 .VSBMU 5IJO 'JMN #VML

& 1 %VQPOU 3 -VJTJFS . (JKT /0"

(SPXUI .FDIBOJTNT JO 1FSJUFDUJD "MMPZT 4PMJEJGJFE BU -PX 4QFFE BO 9 3BZ 5PNP HSBQIZ 4UVEZ PG $V 4O .FU .BUFS 5SBOT

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BT B 67 DVSBCMF NBUFSJBM GPS GBCSJDBUJPO PG NJDSPGMVJEJD DIBOOFMT XJUI OBUJWF IZESPQIJMJDJUZ .JDSPFMFDUSPOJD &OHJOFFSJOH

JO QSFTT

. (JKT + 7¨S¨T &E 4QSJOHFS

JO QSFTT

MMNS

, & .PTFMVOE % #PVWFU " . *POFTDV

# 4U EMFS . -JNBDIFS / -J + 7¨S¨T

5PQ EPXO TJMJDPO OBOPXJSF GBCSJDBUJPO QMBUGPSN IJHI NPCJMJUZ (BUF "MM "SPVOE .04'&5T BOE *NQBDU *POJ[BUJPO %FWJDFT $IBQUFS JO Ä/BOPTZTUFN %FTJHO BOE 5FDIOPMPHZÅ ( EF .JDIFMJ : -FCMFCJDJ

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. (JKT + 7¨S¨T &E 4QSJOHFS

7 "V[FMZUF + 7¨S¨T 4JNVMUBOFPVT 0QUJDBM

5ISFF %JNFOTJPOBMMZ %FTJHOFE $FMM $VMUVSFT $POTJTUJOH PG .JDSPTUSVDUVSFE $FMM 4IFFUT BOE 1PMZNFS -BZFST GPS 5JTTVF &OHJOFFSJOH

Janos Vörös

ETH Zurich

EPFL, Unispital Zurich

MatLife

( " 4BMWBUPSF % #PVWFU * 4UPMJUDIOPW

&MFDUSJDBM .FBTVSFNFOUT JO /BOPXJSF "SSBZT TVCNJUUFE UP /BOP-FUUFST

1MBUGPSN GPS IJHI EFOTJUZ QBSBMMFM TDSFFOJOH PG NFNCSBOF SFDFQUPS GVODUJPO

Horst Vogel

EPFL

ETH Zurich (2), CSEM

MatLife

4UVEZJOH 4JOHMF $FMMT JO &OHJOFFSFE % .JDSPFOWJSPONFOUT

Viola Vogel

ETH Zurich

ETH Zurich, Empa

MatLife

Martin Gijs

EPFL

EPFL (6), CSEM

MMNS

Yusuf Leblebici

EPFL

EPFL (4), CSEM, ETH Zurich

MMNS

Janos Vörös

ETH Zurich

ETH Zurich, PSI

MMNS

Stuart Holdsworth

Empa

ETH Zurich, PSI

MERU

Helena Van Swygenhoven

PSI

Empa (2)

MERU

Michel Rappaz & Alain Jacot

EPFL

Empa, PSI

MERU

Ralph Spolenak

ETH Zurich

PSI

MERU

Nicholas Spencer

ETH Zurich

Empa

NNMC

Christian Depeursinge

EPFL

EPFL, CSEM

NNMC

Davide Ferri

Empa

ETH Zurich, Empa

NNMC

Jean-Daniel Ganière

EPFL

ETH Zurich

NNMC

.JDSPUPNF 4*.4 $IFNJDBM 5PNPHSBQIZ PG #JPMPHJDBM .BUFSJBM XJUI ON 3FTPMVUJPO

Beat Keller

Empa

UniSpital Basel

NNMC

/BOP 9BT

Iris Schmid

Empa

PSI

NNMC

%FWFMPQNFOU PG B 9 SBZ QIBTF DPOUSBTU JOTUSVNFOU GPS UIF DIBSBDUFSJ[BUJPO PG NBUFSJBMT XJUI MPX BUPNJD NBTT

Claus Urban

CSEM

Empa

NNMC

Susan Meuwly

EPFL

–

NNMC

+ "VFSTXBME 4 #FSDIUPME + . %JTFSFOT . " . (JKT : ) +JO ) ' ,OBQQ : -FUFSSJFS + " & .ËOTPO ( 4V SF[ BOE ( 7PJSJO

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/ 4FUUFS " . *PQOFTDV 'FSSPFMFDUSJD '&5

/BOPDSZTUBMMJOF DFSBNJD UIJO GJMN DPBUJOH XJUIPVU TJOUFSJOH /"/$&3

1IPUPDIFNJDBMMZ GVODUJPOBMJ[BCMF TDBGGPMET GPS 5JTTVF &OHJOFFSJOH BOE /FSWF 3FHFOFSBUJPO

NMMC

-BC PO B DIJQ GPS BOBMZTJT BOE EJBHOPTUJDT

# " ,FMMFS , & .BZFSIPGFS 5IF 3PMF PG

.BUFSJBMT EFWJDFT BOE EFTJHO UFDIOPMPHJFT GPS OBOPFMFDUSPOJD TZTUFNT CFZPOE VMUJNBUFMZ TDBMFE $.04

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/BOPTDBMF SFTPMVUJPO PQUJDBM NJDSPTDPQZ GPS NBUFSJBM JNBHJOH BOE TQFDUSPTDPQZ

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. 4UBOJTBWMKFWJD " 4DINJE : -FCMFCJDJ

. )FVCFSHFS + 7¨S¨T 0QUJDBM TFOTJOH

$ /JDMBTT & $IBSCPO BOE . " . (JKT "DUVBUJPO

$.04 DIJQ $IBQUFS JO Ä/BOPTZTUFN %FTJHO

" /PWFM 5FDIOJRVF GPS .JOJNJ[BUJPO PG UIF -PDBM %FMBZ 7BSJBUJPOT GPS /BOPTDBMF $.04 5FDIOPMPHJFT $IBQUFS JO Ä/BOPTZTUFN %FTJHO BOE 5FDIOPMPHZÅ

BOE EFUFSNJOBUJPO PG DPNQMFY SFGMFDUJPO DPFGGJDJFOUT PG QMBTNPOJD TUSVDUVSFT VTJOH USBOTNJTTJPO JOUFSGFSPNFUSJD QMBTNPOJD TFOTPS TVCNJUUFE UP 3FW 4DJ *OTUS

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&E 4QSJOHFS

B CJP BOBMZUJDBM NJDSPTZTUFN XJUI JOUFHSBUFE

Annual Activity Report 2009

.PEFMMJOH PG EFGFDU GPSNBUJPO JO TPMJEJGJDBUJPO QSPDFTTFT VTJOH HSBOVMBS EZOBNJDT BOE QIBTF GJFME BQQSPBDIFT $PNCJOBUPSJBM TUVEZ BOE NPEFMJOH PG PQUJDBM QSPQFSUJFT PG HPME BMMPZT

5 4BOOPNJZB 5 #BMNFS $ )BGOFS

BOE EFUFDUJPO PG NBHOFUJD NJDSPQBSUJDMFT JO

*O TJUV NFDIBOJDBM UFTUJOH

) #FO +BNBB ( EF .JDIFMJ : -FCMFCJDJ

34

Principal Investigator (PI)

Title of project

5JNF SFTPMWFE DBUIPEPMVNJOFTDFODF 53$-

.B$) 5IF "OBMZUJDBM &RVJQNFOU %BUBCBTF

Annual Activity Report 2009

35

Projects funded in 2009

2009 Peer reviewed publications " # 1IJMMJPO + - %FTCJPMMFT . 3BQQB[

3 .BD,FO[JF 7 "V[FMZUF 4 0MMJHFT

# ,IFSBENBOE #PSPVKFOJ $ 1JHVFU : -FCMFCJDJ

" % (SBOVMBS .PEFM PG &RVJBYFE (SBOVMBS 4PMJEJGJDBUJPO JO .PEFMJOH PG $BTUJOH 8FMEJOH BOE "EWBODFE 4PMJEJGJDBUJPO 1SPDFTTFT 9** 4 - $PDLDSPGU BOE % . .BJKFS

3 4QPMFOBL ) ) 4PMBL BOE + 7¨S¨T

"EBQUJWF 7HT " /PWFM 5FDIOJRVF GPS $POUSPMMJOH 1PXFS BOE %FMBZ PG -PHJD (BUFT JO 4VC 75 3FHJNF $IBQUFS JO Ä/BOPTZTUFN %FTJHO BOE 5FDIOPMPHZÅ

&E 5.4 QQ

/BOPXJSF %FWFMPQNFOU BOE $IBSBDUFSJ[B UJPO GPS "QQMJDBUJPOT JO #JPTFOTJOH $IBQUFS JO Ä/BOPTZTUFN %FTJHO BOE 5FDIOPMPHZÅ ( EF .JDIFMJ : -FCMFCJDJ

( EF .JDIFMJ : -FCMFCJDJ . (JKT + 7¨S¨T

. (JKT + 7¨S¨T &E 4QSJOHFS

&E 4QSJOHFS

. 3BQQB[ ' ,PIMFS + 7BMMPUPO " # 1IJMMJPO

PI’s Institution

Others Institutions

ERU/ Platform

Philippe Renaud

EPFL

EPFL (2), PSI

SPERU

Jennifer Rupp

ETH Zurich

ETH Zurich, Empa, PSI (2)

SPERU

4NBSU GVODUJPOBM GPBNT

Ludwig Gauckler

ETH Zurich

EPFL, ETH Zurich (2)

SPERU

;FSP PSEFS OBOP PQUJDBM QJHNFOUT ;0/01

Alexander Stuck

CSEM

EPFL

SPERU

Christian Hinderling & Matha Liley

CSEM

ETH Zurich (2)

MatLife

*NNVOPGVODUJPOBM /BOPQBSUJDMFT

Jeffrey Hubbell

EPFL

EPFL, ETH Zurich

MatLife

.VMUJWBMFOU -FDUJO "SSBZ " $PNCJOBUPSJBM "QQSPBDI

Peter Seeberger

ETH Zurich

ETH Zurich

MatLife

#JP GVODUJPOBMJ[FE CJPEFHSBEBCMF OBOPTUSVDUVSFE NBHOFTJVN JNQMBOU GPS CJPNFEJDBM BQQMJDBUJPOT

Samuele Tosatti

ETH Zurich

ETH Zurich (4), Empa

MatLife

%FWFMPQNFOU PG OPWFM NFUIPET GPS TVSGBDF NPEJGJDBUJPO BOE JOWFTUJHBUJPO PG DFMM QBSUJDMFT JOUFSBDUJPO GPS TVQFSQBSBNBHOFUJD OBOPQBSUJDMFT 1"1".0%

. 4UBNQBOPOJ $POOFDUJWJUZ PG 1IBTFT BOE

& .JMZVUJO BOE 1 .VSBMU 5IJO 'JMN #VML

& 1 %VQPOU 3 -VJTJFS . (JKT /0"

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"DPVTUJD 8BWF 3FTPOBUPST GPS (SBWJNFUSJD 4FOTJOH $IBQUFS JO Ä/BOPTZTUFN %FTJHO BOE 5FDIOPMPHZÅ ( EF .JDIFMJ : -FCMFCJDJ

BT B 67 DVSBCMF NBUFSJBM GPS GBCSJDBUJPO PG NJDSPGMVJEJD DIBOOFMT XJUI OBUJWF IZESPQIJMJDJUZ .JDSPFMFDUSPOJD &OHJOFFSJOH

JO QSFTT

. (JKT + 7¨S¨T &E 4QSJOHFS

JO QSFTT

MMNS

, & .PTFMVOE % #PVWFU " . *POFTDV

# 4U EMFS . -JNBDIFS / -J + 7¨S¨T

5PQ EPXO TJMJDPO OBOPXJSF GBCSJDBUJPO QMBUGPSN IJHI NPCJMJUZ (BUF "MM "SPVOE .04'&5T BOE *NQBDU *POJ[BUJPO %FWJDFT $IBQUFS JO Ä/BOPTZTUFN %FTJHO BOE 5FDIOPMPHZÅ ( EF .JDIFMJ : -FCMFCJDJ

1IPUPCMFBDIJOH *OEVDFE %BNBHF PG #JPNPMFDVMFT 4USFQUBWJEJO BT #JP 1IP UPSFTJTU 4VSGBDF 4DJFODF JO QSFTT

3 .BD,FO[JF $ 'SBTDIJOB 5 4BOOPNJZB

. (JKT + 7¨S¨T &E 4QSJOHFS

7 "V[FMZUF + 7¨S¨T 4JNVMUBOFPVT 0QUJDBM

5ISFF %JNFOTJPOBMMZ %FTJHOFE $FMM $VMUVSFT $POTJTUJOH PG .JDSPTUSVDUVSFE $FMM 4IFFUT BOE 1PMZNFS -BZFST GPS 5JTTVF &OHJOFFSJOH

Janos Vörös

ETH Zurich

EPFL, Unispital Zurich

MatLife

( " 4BMWBUPSF % #PVWFU * 4UPMJUDIOPW

&MFDUSJDBM .FBTVSFNFOUT JO /BOPXJSF "SSBZT TVCNJUUFE UP /BOP-FUUFST

1MBUGPSN GPS IJHI EFOTJUZ QBSBMMFM TDSFFOJOH PG NFNCSBOF SFDFQUPS GVODUJPO

Horst Vogel

EPFL

ETH Zurich (2), CSEM

MatLife

4UVEZJOH 4JOHMF $FMMT JO &OHJOFFSFE % .JDSPFOWJSPONFOUT

Viola Vogel

ETH Zurich

ETH Zurich, Empa

MatLife

Martin Gijs

EPFL

EPFL (6), CSEM

MMNS

Yusuf Leblebici

EPFL

EPFL (4), CSEM, ETH Zurich

MMNS

Janos Vörös

ETH Zurich

ETH Zurich, PSI

MMNS

Stuart Holdsworth

Empa

ETH Zurich, PSI

MERU

Helena Van Swygenhoven

PSI

Empa (2)

MERU

Michel Rappaz & Alain Jacot

EPFL

Empa, PSI

MERU

Ralph Spolenak

ETH Zurich

PSI

MERU

Nicholas Spencer

ETH Zurich

Empa

NNMC

Christian Depeursinge

EPFL

EPFL, CSEM

NNMC

Davide Ferri

Empa

ETH Zurich, Empa

NNMC

Jean-Daniel Ganière

EPFL

ETH Zurich

NNMC

.JDSPUPNF 4*.4 $IFNJDBM 5PNPHSBQIZ PG #JPMPHJDBM .BUFSJBM XJUI ON 3FTPMVUJPO

Beat Keller

Empa

UniSpital Basel

NNMC

/BOP 9BT

Iris Schmid

Empa

PSI

NNMC

%FWFMPQNFOU PG B 9 SBZ QIBTF DPOUSBTU JOTUSVNFOU GPS UIF DIBSBDUFSJ[BUJPO PG NBUFSJBMT XJUI MPX BUPNJD NBTT

Claus Urban

CSEM

Empa

NNMC

Susan Meuwly

EPFL

–

NNMC

+ "VFSTXBME 4 #FSDIUPME + . %JTFSFOT . " . (JKT : ) +JO ) ' ,OBQQ : -FUFSSJFS + " & .ËOTPO ( 4V SF[ BOE ( 7PJSJO

-BC PO B DIJQ GPS "OBMZTJT BOE %JBHOPTUJDT "QQMJDBUJPO UP .VMUJQMFYFE %FUFDUJPO PG "OUJCJPUJDT JO .JML $IBQUFS JO Ä/BOPTZTUFN %FTJHO BOE 5FDIOPMPHZÅ ( EF .JDIFMJ : -FCMF CJDJ . (JKT + 7¨S¨T &E 4QSJOHFS

/ 4FUUFS " . *PQOFTDV 'FSSPFMFDUSJD '&5

/BOPDSZTUBMMJOF DFSBNJD UIJO GJMN DPBUJOH XJUIPVU TJOUFSJOH /"/$&3

1IPUPDIFNJDBMMZ GVODUJPOBMJ[BCMF TDBGGPMET GPS 5JTTVF &OHJOFFSJOH BOE /FSWF 3FHFOFSBUJPO

NMMC

-BC PO B DIJQ GPS BOBMZTJT BOE EJBHOPTUJDT

# " ,FMMFS , & .BZFSIPGFS 5IF 3PMF PG

.BUFSJBMT EFWJDFT BOE EFTJHO UFDIOPMPHJFT GPS OBOPFMFDUSPOJD TZTUFNT CFZPOE VMUJNBUFMZ TDBMFE $.04

1 , 4BIPP 5 5IPNTPO " 5VSDIBOJO $ %BWJE

XJUI TVC ON $PQPMZNFS 1 7%' 5S'&

(BUF %JFMFDUSJD GPS /PO 7PMBUJMF .FNPSZ $IBQUFS JO Ä/BOPTZTUFN %FTJHO BOE 5FDIOPMPHZÅ ( EF .JDIFMJ : -FCMFCJDJ

) ) 4PMBL &YUSFNF VMUSBWJPMFU JOUFSGFSFODF

. (JKT + 7¨S¨T &E 4QSJOHFS

+PVSOBM PG /BOPNFEJDJOF

%FWFMPQNFOU BOE DIBSBDUFSJ[BUJPO PG OBOPXJSFT GPS BQQMJDBUJPOT JO CJP FMFDUSPOJDT

" .BHSF[ - 'PSSP .BUFSJBMT GPS 1JF[PFMFD

+ ,¬IO ' .POUGPSU 5 $PMPNC # 3BQQB[

&WPMVUJPO PG NJDSPTUSVDUVSF BOE NFDIBOJDBM SFTQPOTF EVF UP DZDMJD EFGPSNBUJPO BU FMFWBUFE UFNQFSBUVSFT

USJD /BOPEFWJDFT $IBQUFS JO Ä/BOPTZTUFN

$ .PSBUBM / 1BWJMMPO 1 .BSRVFU $ %FQFVSTJOHF

%FTJHO BOE 5FDIOPMPHZÅ ( EF .JDIFMJ :

4VCNJDSPNFUFS UPNPHSBQIZ PG DFMMT CZ NVMUJQMF XBWFMFOHUI EJHJUBM IPMPHSBQIJD NJDSPTDPQZ JO SFGMFDUJPO 0QU -FUU

7 "V[FMZUF $ %BJT 1 'BSRVFU % (S¬U[NBDIFS - + )FZEFSNBO ' -VP 4 0MMJHFT $ 1BEFTUF

50' 4*.4 JO /BOPNFEJDJOF &VSPQFBO

MJUIPHSBQIZ BU UIF 1BVM 4DIFSSFS *OTUJUVU +PVSOBM .JDSP /BOPMJUIPHSBQIZ .&.4 BOE .0&.4

7 "V[FMZUF " -BOHOFS ) ) 4PMBL 5IFSNBM

-FCMFCJDJ . (JKT + 7¨S¨T &E 4QSJOHFS

EFWFMPQNFOU PG B DBMJYBSFOF SFTJTU + 7BD 4DJ 5FDIOPM #

& 1 %VQPOU & -BCPOOF $ 7BOEFWZWFS 6 -FINBOO & $IBSCPO . (JKT .POPMJUIJD

4JMJDPO $IJQ GPS *NNVOPGMVPSFTDFODF %FUFDUJPO PO 4JOHMF .BHOFUJD #FBET "OBM $IFN QQ

'BVMU UPMFSBOU EFTJHO BQQSPBDIFT GPS SFHVMBS BSSBZT CBTFE PO TJMJDPO OBOPXJSFT $IBQUFS JO Ä/BOPTZTUFN %FTJHO BOE 5FDIOPMPHZÅ ( EF .JDIFMJ : -FCMFCJDJ

5 $PMPNC 4 ,SJWFD ) )VUUFS " "LBUBZ

-BCFM GSFF JNBHJOH PG NPMFDVMBS BETPSQUJPO PO JO TJUV TVSGBDF GVODUJPOBM QBUUFSOT

/ 1BWJMMPO ' .POUGPSU & $VDIF + ,¬IO $ %FQFVSTJOHF : &NFSZ %JHJUBM IPMPHSBQIJD

/BOPTDBMF SFTPMVUJPO PQUJDBM NJDSPTDPQZ GPS NBUFSJBM JNBHJOH BOE TQFDUSPTDPQZ

SFGMFDUPNFUSZ 0QU &YQSFTT JO QSFTT

7JCSBUJPOBM TQFDUSPTDPQZ PG OBOPTUSVDUVSFE TVSGBDF TZTUFNT

. (JKT + 7¨S¨T &E 4QSJOHFS

6 -FINBOO . 4FSHJP & 1 %VQPOU & -BCPOOF

. 4UBOJTBWMKFWJD " 4DINJE : -FCMFCJDJ

. )FVCFSHFS + 7¨S¨T 0QUJDBM TFOTJOH

$ /JDMBTT & $IBSCPO BOE . " . (JKT "DUVBUJPO

$.04 DIJQ $IBQUFS JO Ä/BOPTZTUFN %FTJHO

" /PWFM 5FDIOJRVF GPS .JOJNJ[BUJPO PG UIF -PDBM %FMBZ 7BSJBUJPOT GPS /BOPTDBMF $.04 5FDIOPMPHJFT $IBQUFS JO Ä/BOPTZTUFN %FTJHO BOE 5FDIOPMPHZÅ

BOE EFUFSNJOBUJPO PG DPNQMFY SFGMFDUJPO DPFGGJDJFOUT PG QMBTNPOJD TUSVDUVSFT VTJOH USBOTNJTTJPO JOUFSGFSPNFUSJD QMBTNPOJD TFOTPS TVCNJUUFE UP 3FW 4DJ *OTUS

BOE 5FDIOPMPHZÅ ( EF .JDIFMJ : -FCMFCJDJ

( EF .JDIFMJ : -FCMFCJDJ . (JKT + 7¨S¨T

. (JKT + 7¨S¨T &E 4QSJOHFS

&E 4QSJOHFS

B CJP BOBMZUJDBM NJDSPTZTUFN XJUI JOUFHSBUFE

Annual Activity Report 2009

.PEFMMJOH PG EFGFDU GPSNBUJPO JO TPMJEJGJDBUJPO QSPDFTTFT VTJOH HSBOVMBS EZOBNJDT BOE QIBTF GJFME BQQSPBDIFT $PNCJOBUPSJBM TUVEZ BOE NPEFMJOH PG PQUJDBM QSPQFSUJFT PG HPME BMMPZT

5 4BOOPNJZB 5 #BMNFS $ )BGOFS

BOE EFUFDUJPO PG NBHOFUJD NJDSPQBSUJDMFT JO

*O TJUV NFDIBOJDBM UFTUJOH

) #FO +BNBB ( EF .JDIFMJ : -FCMFCJDJ

34

Principal Investigator (PI)

Title of project

5JNF SFTPMWFE DBUIPEPMVNJOFTDFODF 53$-

.B$) 5IF "OBMZUJDBM &RVJQNFOU %BUBCBTF

Annual Activity Report 2009

35

CCMX Team

Management 1SPG ,BSFO 4DSJWFOFS $IBJS LBSFO TDSJWFOFS!FQGM DI %S /BUIBMJF +POHFO .BOBHJOH %JSFDUPS OBUIBMJF KPOHFO!FQGM DI ,BUIMFFO $PMMJOT "ENJOJTUSBUPS LBUIMFFO DPMMJOT!FQGM DI 4V[BOOF 'FSFOD[J $POUSBDUT 'JOBODF .BOBHFS TV[BOOF GFSFOD[J!FQGM DI

SPERU Surface, coatings and particles engineering 1SPG )FJOSJDI )PGNBOO &1'- %JSFDUPS IFJOSJDI IPGNBOO!FQGM DI %S /BUIBMJF +POHFO 4DJFOUJGJD BOE JOEVTUSJBM MJBJTPO PGGJDFS OBUIBMJF KPOHFO!FQGM DI %S /JLMBVT #¬IMFS 4DJFOUJGJD BOE JOEVTUSJBM MJBJTPO PGGJDFS OJLMBVT CVFIMFS!FQGM DI

MatLife Materials for the life sciences %S ,BUIBSJOB .BOJVSB &NQB %JSFDUPS LBUIBSJOB NBOJVSB!FNQB DI "OOF ,BUISJO #PSO 4DJFOUJGJD BOE JOEVTUSJBM MJBJTPO PGGJDFS BOOF LBUISJO CPSO!FNQB DI %S 8BMUFS 4DIJMMJOH 4DJFOUJGJD BOE JOEVTUSJBM MJBJTPO PGGJDFS XBMUFS TDIJMMJOH!CMVFXJO DI

36

Annual Activity Report 2009

MERU Metallurgy 1SPG .JDIFM 3BQQB[ &1'- %JSFDUPS NJDIFM SBQQB[!FQGM DI 4VTBO .FVXMZ 4DJFOUJGJD BOE JOEVTUSJBM MJBJTPO PGGJDFS TVTBO NFVXMZ!FQGM DI

NMMC Nano- and microscale materials characterisation for industry and academia 1SPG )BOT +PTFG )VH &NQB %JSFDUPS IBOT KPTFG IVH!FNQB DI $IJBSB $PSUJDFMMJ 4DJFOUJGJD BOE JOEVTUSJBM MJBJTPO PGGJDFS DIJBSB DPSUJDFMMJ!FNQB DI 4VTBO .FVXMZ 4DJFOUJGJD DPPSEJOBUPS TVTBO NFVXMZ!FQGM DI

CCMX Steering Committee 1SPG ,BSFO 4DSJWFOFS &1'- $IBJS %S +BDRVFT #BVS 3PMFY

1SPG 3PMBOE 4JFHXBSU &5);

%S 1JFSBOHFMP (S¨OJOH &NQB

%S "MFY %PNNBOO $4&.

1SPG +BO "OEFST .BOTPO &1'-

%S )BOT 8BMUFS 4DIM QGFS 4VM[FS

1SPG 3BMQI 4QPMFOBL &5);

1SPG 'SJTP WBO EFS 7FFO 14*

CCMX International Advisory Board 1SPG &EVBSE "S[U 4BBSMBOE 6OJWFSTJUZ

1SPG %BWJE (SBJOHFS 6OJWFSTJUZ PG 6UBI

1SPG 1IJMJQQF .BSDVT &DPMF /BUJPOBMF 4VQ SJFVSF EF $IJNJF

ANNUAL ACTIVITY REPORT 2009

www.ccmx.ch Texts :

Elsbeth Heinzelmann, Bern&CCMX

Photos :

CCMX, EPFL, ETH Zurich, Empa, PSI, CSEM Layout & design :

www.antidote-design.ch Printing :

Images3 (www.images3.ch) Š CCMX, April 2010