This is syllabus of the 2021/22 round of the Research & Design studio ‘Spatial Strategies for the Global Metropolis’, which runs during the third quarter of the MSc Urbanism programme at Delft University of Technology. Regional design is the core theme of this quarter. Students use the practice to explore plausible futures, and to debates solutions to problems in a given context. Two interrelated themat¬ic topics were at students’ focus during the studio round, notably (1) a transi¬tion towards a circular port of Rotterdam economy, and (2) a social transition which is expected to happen in tandem with the port’s enhanced circularity. The responsible section of the quarter Spatial Strategies for the Global Metropolis is Spatial Planning & Strategy.