This is syllabus of the 2020/21 round of the Research & Design studio ‘Spatial Strategies for the Global Metropolis’, which runs during the third quarter of the MSc Urbanism programme at Delft University of Technology. Regional design is the core theme of this quarter. Students use the practice to explore plausible futures, and to debates solutions to problems in a given context. The thematic focus of this round of the studio was informed by an ambitious policy agenda that the Province of South Holland has set out: aligned with objectives of the Dutch national government, it intends to host a 100% circular economy by 2050. The responsible section of the quarter Spatial Strategies for the Global Metropolis is Spatial Planning & Strategy.