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USA FISH Probe Catalog
2012/2013
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cytocell.com Our website provides a detailed account of our comprehensive range of FISH probes and accessories. It also provides details of your local contact from our network of international distributors who will be happy to take your order. For a complete list of worldwide distributors please go to:
www.cytocell.com
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Introduction
An Introduction to Cytocell Cytocell’s FISH business is now the oldest and most experienced in the world. From humble beginnings, the first products were developed 20 years ago in Birmingham Heartlands Hospital, England, where, in 1991, the patented process, Chromoprobe®, was developed. Initially thanks to this technology, all the products were available reversibly dried onto the surface of special glass coverslips or as arrays of probes on 24 square glass devices. From 1994 these were developed, manufactured and supplied from our new premises in Banbury, near Oxford. In 2006, we moved to our current premises in Cambridge, England and this year we will continue to invest in our manufacturing and R&D facilities by expanding into a new purpose built building. Over the last 20 years, we have actively listened to and acted upon your needs and requirements leading to the development of our current portfolio of FISH probes, these are available in a convenient liquid format and packaged in sizes appropriate to your laboratory workload. At Cytocell we have a long history of collaborating with world-renowned experts. As well as providing clean and quick FISH tests, the development of our product portfolio has led to a number of industry ‘Firsts’, each of which has helped to make FISH a more robust and customer friendly technique:
This latest catalog is our largest to date and contains the single largest collection of FISH probes available from one supplier. Cytocell is committed to the future development and expansion of our probe catalog through the use of our proprietary sequence data and exclusive BAC collection. Under the banner of “myProbes®”, Cytocell is proud to offer our FISH expertise and services to our customers for the development of custom built probes. Using our myProbes service and its new website (www.myprobes.com), we can supply FISH probes tailored to your exact needs and specification.
• 1st to develop directly labeled probes • 1st to provide co-denaturation protocols • 1st to develop subtelomere probes • 1st to develop a single slide assay for subtelomeric aberrations
So celebrate our 20th anniversary with us and enjoy looking through our catalog as we look forward together at the next 20 years and consider what we may achieve together!
• 1st to provide a screening solution for all human chromosomes on a single slide • 1st to provide two-probes-in-one-test solutions We are justifiably proud of our achievements over the last 20 years and equally as proud to have served you, our customers. With the changing face of FISH testing over the last 5 years, Cytocell has continued to innovate and move with the times so that now we have a comprehensive Hematology and Pathology portfolio to complement our Classical Cytogenetics catalog.
Dr. Martin Lawrie Managing Director, Cytocell Ltd.
Cytocell FISH probes are developed and produced in the UK
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Our Products
Our products Cytocell’s DNA Fluorescence In Situ Hybridization (FISH) probes are aimed at two disciplines; Constitutional cytogenetics and Oncology/Pathology cytogenetics.
We offer three key product ranges within the USA: Aquarius® Range Aquarius® probes are directly labeled liquid probes.
myProbes® myProbes® is a custom FISH probe design and manufacture service, which utilizes Cytocell’s proprietary BAC clone collection.
Ancillary Reagents Various Hybridization solutions and DAPI counterstain are available as separate items.
Patents and Trademarks Aquarius, Chromoprobe, Cytocell, Chromoprobe Multiprobe and myProbes are registered trademarks of Cytocell Ltd. The Chromoprobe principle is covered by international patents WO9314223, EP0623177. The design of the Multiprobe is a registered design and is also covered by a Design Patent No. 420,745. Cytocell operates a Quality Management System that is compliant with the FDA 21 CFR part 820 regulations, and has been assessed and certified to both EN ISO 9001:2008 and EN ISO 13485:2003. Please check our website for the latest probe ranges available from Cytocell. www.cytocell.com
Texas Red® dye used in various Cytocell products is provided under an intellectual property license from Life Technologies Corporation. For information on purchasing a license to this dye for purposes other than research, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com
Disclaimer Every attempt has been made to ensure that the information in this catalog is correct at time of going to print. Although every care has been taken in preparing this publication, no responsibility or liability will be accepted by Cytocell Ltd or its employees for its accuracy or completeness. V001/2012_11
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Contents - Oncology & Constitutional FISH
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Contents
Aquarius® Hematology 9
AML1 Breakapart
25
IGH/cMYC Translocation, Dual Fusion
10
AML1/ETO Translocation, Dual Fusion
26
IGH/FGFR3 Translocation, Dual Fusion
11
ATM Deletion
27
IGH/MAF Translocation, Dual Fusion
12
BCR/ABL Translocation, Dual Fusion
28
IGH/MAFB Translocation, Dual Fusion
13
BCR/ABL Plus Translocation, Dual Fusion
29
IGH/MYEOV Translocation, Dual Fusion
14
BCL6 Breakapart
30
IGL Breakapart
15
CBFβ/MYH11 Translocation, Dual Fusion
30
IGK Breakapart
16
CKS1B/CDKN2C (P18) Amplification/Deletion
31
MLL Breakapart
16
cMYC Breakapart
31
MYB Deletion
17
13q14.3 Deletion
32
P16 Deletion
17
D13S319 Deletion
32
P53 Deletion
18
D13S25 Deletion
33
P53/ATM Probe Combination
18
Del (5q) Deletion
34
PDGFRB Breakapart
19
Del (7q) Deletion
35
PML/RARα Translocation, Dual Fusion
19
Del (20q) Deletion
36
TCL1 Breakapart
20
E2A Breakapart
36
TCRAD Breakapart
20
EVI1 Breakapart
37
TCRB Breakapart
21
FIP1L1/CHIC2/PDGFRA Deletion/Fusion
38
TEL/AML1 Translocation, Dual Fusion
21
IGH Breakapart
39
TLX1 Breakapart
22
IGH/BCL2 Translocation, Dual Fusion
39
TLX3 Breakapart
23
IGH/CCND1 Translocation, Dual Fusion
40
Aquarius® Hematology Panel
24
IGH/CCND3 Translocation, Dual Fusion
Aquarius® Pathology
4
43
Tissue Pretreatment Kit
50
MDM2 Amplification
44
ALK Breakapart
51
N-MYC Amplification
44
CHOP Breakapart
51
PAX3 Breakapart
45
C-MET Amplification
52
PAX7 Breakapart
45
EGFR Amplification
52
RB1 Deletion
46
EML4 Breakpart
53
SRD (CHD5) Deletion
46
EWSR1 Breakapart
53
SYT Breakapart
47
EWSR1/ERG Translocation, Dual Fusion
54
TMPRSS2 Breakapart
48
FLI1/EWSR1 Translocation, Dual Fusion
54
ERG Control
49
FGFR1 Breakapart/Amplification
55
TOP2A Amplification/Deletion
49
HER2 Amplification
55
ZNF217 Amplification
50
MALT1 Breakapart
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59
Alagille (JAG1) Region
59
Angelman (UBE3A/D15S10) Region
60
CHARGE Region
61
Cri-Du-Chat Region/SOTOS Region
62
DiGeorge II (10p14)
63
DiGeorge/VCFS TUPLE1 Region & 22q13.3 Region
64
DiGeorge/VCFS N25 Region & 22q13.3 Region
65
DiGeorge TBX1 Region & 22q13.3 Region
66
Kallmann (KAL1) Region/STS Region
67
Langer-Giedion Region
67
Monosomy 1p36 Region
68
Neurofibromatosis Type 1 Region
68
Prader-Willi/Angelman (SNRPN) Region
69
Rubinstein-Taybi Region
70
Saethre-Chotzen Region/Williams-Beuren Region
71
SHOX
72
Smith-Magenis (FLII) Region/Miller-Dieker Region
73
Smith-Magenis (RAI1) Region/Miller-Dieker Region
74
SRY
74
Williams-Beuren Region
75
Wolf-Hirschhorn Region
76
XIST
Contents - Oncology & Constitutional FISH
Subtelomere Specific Probes
Aquarius速 Microdeletion 78
Subtelomere Specific Probes
Paints 82
Whole Chromosome Painting Probes
Satellites 84
Satellite Enumeration Probes
85
Blue Labeled Satellite Enumeration Probes
85
Dual Labeled Satellite Probe Sets
85
Acro-P-Arm Probe
Accessories 88
Accessories
Ordering Information 90
Ordering Information
96
Index by Chromosome Number
98
Index by Probe Name
5
Aquarius速 Hematology
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Aquarius速 Hematology
Hematology
Aquarius® Hematology
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Contents
8
9
AML1 Breakapart
10
AML1/ETO Translocation, Dual Fusion
11
ATM Deletion
12
BCR/ABL Translocation, Dual Fusion
13
BCR/ABL Plus Translocation, Dual Fusion
14
BCL6 Breakapart
15
CBFβ/MYH11 Translocation, Dual Fusion
16
CKS1B/CDKN2C (P18) Amplification/Deletion
16
cMYC Breakapart
17
13q14.3 Deletion
17
D13S319 Deletion
18
D13S25 Deletion
18
Del (5q) Deletion
19
Del (7q) Deletion
19
Del (20q) Deletion
20
E2A Breakapart
20
EVI1 Breakapart
21
FIP1L1/CHIC2/PDGFRA Deletion/Fusion
21
IGH Breakapart
22
IGH/BCL2 Translocation, Dual Fusion
23
IGH/CCND1 Translocation, Dual Fusion
24
IGH/CCND3 Translocation, Dual Fusion
25
IGH/cMYC Translocation, Dual Fusion
26
IGH/FGFR3 Translocation, Dual Fusion
27
IGH/MAF Translocation, Dual Fusion
28
IGH/MAFB Translocation, Dual Fusion
29
IGH/MYEOV Translocation, Dual Fusion
30
IGL Breakapart
30
IGK Breakapart
31
MLL Breakapart
31
MYB Deletion
32
P16 Deletion
32
P53 Deletion
33
P53/ATM Probe Combination
34
PDGFRB Breakapart
35
PML/RARα Translocation, Dual Fusion
36
TCL1 Breakapart
36
TCRAD Breakapart
37
TCRB Breakapart
38
TEL/AML1 Translocation, Dual Fusion
39
TLX1 Breakapart
39
TLX3 Breakapart
40
Aquarius® Hematology Panel
Hematology Cytocell offers a range of Hematological probes available in the Aquarius® liquid format. These probes are directly labeled, ready to use in hybridization buffer and available in an economical 50 and larger 100µl volumes.
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Aquarius® Hematology
Cat. No. LPH 027-SA (50μl) Cat. No. LPH 027-A (100μl)
AML1 Breakapart The AML1 product consists of a 148Kb probe, labeled in red, located centromeric to the AML1 (RUNX1) gene, including the CLIC6 gene and a green probe, covering a 167Kb region including the telomeric end of the AML1 (RUNX1) gene and extending beyond the D21S1921 marker. Probe Specification
AML1, 21q22.12, Red AML1, 21q22.12, Green
AML1 Chromosome 21
DSCR1 (RCAN1)
CLIC6
AML1 (RUNX1) D21S326 D21S1706 D21S1895 D21S393 D21S1969 D21S1921
148Kb
167Kb 100Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
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Aquarius® Hematology
Cat. No. LPH 026-SA (50μl) Cat. No. LPH 026-A (100μl)
AML1/ETO Translocation, Dual Fusion The AML1 probe mix, labeled in red, consists of a 148Kb probe centromeric to the AML1 (RUNX1) gene, including the CLIC6 gene and a 167Kb probe covering the telomeric end of the AML1 (RUNX1) gene and extending beyond the marker D21S1921. The ETO probe mix, labeled in green, consists of the two probes, 149Kb and 148Kb, on either side of the ETO gene. Probe Specification
AML1, 21q22.12, Red ETO, 8q21.3, Green
AML1 Chromosome 21
DSCR1
AML1 (RUNX1)
CLIC6
D21S326 D21S1706 D21S1895 D21S393 D21S1969 D21S1921
167Kb
148Kb 100Kb
ETO Chromosome 8
ETO (CBFA2T1) D8S1648 D8S1950 D8S1952 D8S2020 D8S1603
D8S412
148Kb
149Kb 100Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
10
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Aquarius® Hematology
Cat. No. LPH 011-SA (50μl) Cat. No. LPH 011-A (100μl)
ATM Deletion The ATM probe is 180Kb, labeled in red, and covers the telomeric end of the NPAT gene and the centromeric end of the ATM gene to just beyond the D11S3347 marker. The probe mix also contains a control probe for the 11 centromere (D11Z1) labeled in green. Probe Specification
ATM, 11q22.3, Red D11Z1, 11p11.1-q11.1, Green
D11Z1
ATM Chromosome 11
NPAT
ATM D11S3347 D11S2179
180Kb 100Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
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Aquarius® Hematology
Cat. No. LPH 007-SA (50μl) Cat. No. LPH 007-A (100μl)
BCR/ABL Translocation, Dual Fusion The BCR probe mix contains a probe, which extends 169Kb centromeric to BCR and contains the genes GNAZ and RAB36. A second probe covers a 148Kb region, which is positioned 261Kb telomeric to BCR. Both are labeled in green. For ABL1 a probe contig covers 346Kb from the middle of the FUBP3 gene to a point 64Kb telomeric to ABL1 and it is labeled in red. There is an additional probe that covers a 173Kb region and spans the whole ASS1 gene. The ASS1 probe is located 212Kb from centromeric end of the ABL1 gene. Probe Specification
ABL1, 9q34, Red BCR, 22q11, Green
BCR Chromosome 22
GNAZ RAB36
BCR
D22S1002E D22S257
IGLL1
D22S1027
148Kb
169Kb 100Kb
ABL1 Chromosome 9
ASS1
D9S2057
173Kb
FUBP3 PRDM12
ABL1
LAMC3 D9S313
D9S1863
346Kb 100kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
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Aquarius® Hematology
Cat. No. LPH 038-SA (50μl) Cat. No. LPH 038-A (100μl)
BCR/ABL Plus Translocation, Dual Fusion The BCR probe mix contains a probe, which extends 169Kb centromeric to BCR and contains the genes GNAZ and RAB36. A second probe covers a 148Kb region, which is positioned 261Kb telomeric to BCR. Both are labeled in green. For ABL1 a probe contig covers 346Kb from the middle of the FUBP3 gene to a point 64Kb telomeric to ABL1 and it is labeled in red. There is an additional blue probe that covers a 173Kb region and spans the whole ASS1 gene. The ASS1 probe is located 212Kb from centromeric end of the ABL1 gene. Probe Specification
ABL1, 9q34, Red BCR, 22q11, Green ASS1, 9q34, Blue
BCR Chromosome 22
GNAZ RAB36
BCR
D22S1002E D22S257
IGLL1
D22S1027
148Kb
169Kb 100Kb
ABL1 Chromosome 9
ASS1
D9S2057
173Kb
FUBP3 PRDM12
ABL1
LAMC3 D9S313
D9S1863
346Kb 100kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
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Aquarius® Hematology
Cat. No. LPH 035-SA (50μl) Cat. No. LPH 035-A (100μl)
BCL6 Breakapart The BCL6 product consists of a 165Kb probe, labeled in red, centromeric to the BCL6 gene and a green probe covering a 170Kb region telomeric to the BCL6 gene. Probe Specification
BCL6, 3q27.3, Red BCL6, 3q27.3, Green
BCL6 Chromosome 3
BCL6 SST RTP2 G67157
D3S4344
165Kb
170Kb 100Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
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Aquarius® Hematology
Cat. No. LPH 022-SA (50μl) Cat. No. LPH 022-A (100μl)
CBFβ/MYH11 Translocation, Dual Fusion The CBFβ probe, labeled in red, covers a 617Kb region within 16q22 and includes the CBFβ gene. The MYH11 probe, labeled in green, covers a 610Kb region within 16p13 and includes the MYH11 gene. Probe Specification
CBFβ, 16q22, Red MYH11, 16p13, Green
CBFB Chromosome 16
CBFB D16S3308 D16S2584E D16S2846
D16S301 D16S324 D16S3339 D16S3323 617Kb
100Kb
MYH11 Chromosome 16
MYH11 D16S3302 D16S3060
D16S2853 D16S3286 D16S2803 D16S405 D16S3127
D16S3292
610Kb
100Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
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Aquarius® Hematology
Cat. No. LPH 039-SA (50μl) Cat. No. LPH 039-A (100μl)
CKS1B/CDKN2C (P18) Amplification/Deletion The CKS1B/CDKN2C product consists of a 180Kb probe, labeled in red, covering the entire CKS1B gene and flanking regions, including the PYOG2 and ZBTB7B genes, and a green probe covering a 168Kb region, including the entire CDKN2C (P18) gene, the D1S1661 marker and the centromeric end of the FAF1 gene. Probe Specification
CKS1B, 1q21, Red CDKN2C (P18), 1p32.3, Green CKS1B
CDKN2C (P18)
Chromosome 1
FAF1
CKS1B CDKN2C
PYOG2
ZBTB7B
D1S1661 180Kb
168Kb
100Kb
Cat. No. LPH 010-SA (50μl) Cat. No. LPH 010-A (100μl)
cMYC Breakapart The cMYC product consists of a 173Kb probe, labeled in red, located 326Kb centromeric to MYC gene, including the marker D8S1153 and a green probe covering a 186Kb region located 380Kb telomeric to MYC gene, including the marker D8S1644. Probe Specification
cMYC, 8q24.21, Red cMYC, 8q24.21, Green MYC Chromosome 8
POU5F1P1 D8S1153
MYC
D8S1128 D8S1980 D8S1720
These products are available as analyte specific reagents.
173Kb
186Kb 100Kb
16
D8S1644
Analytical and performance characteristics are not established.
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Aquarius® Hematology
Cat. No. LPH 006-SA (50μl) Cat. No. LPH 006-A (100μl)
13q14.3 Deletion The 13q14.3 probe, labeled in red, is approximately 600Kb and covers the region between the D13S319 and D13S25 markers. The probe mix also contains a control probe for 13qter (Clone 163C9) labeled in green. Probe Specification
13q14.3, Red 13qter, 13q34, Green
13q14.3
13qter Chromosome 13
DLEU1 D13S25 D13S262
D13S319 D13S272
600Kb 100Kb
Cat. No. LPH 042-SA (50μl) Cat. No. LPH 042-A (100μl)
D13S319 Deletion The D13S319 probe, labeled in red, covers a 177Kb region including the entire DLEU5 and DLEU2 genes and the D13S319, D13S272 and D13S1220 markers. The probe mix also contains a control probe for 13qter (Clone 163C9) labeled in green. Probe Specification
D13S319
D13S319, 13q14.2, Red 13qter, 13q34, Green
13qter Chromosome 13
DLEU5 DLEU2 D13S1220
DLEU1
These products are available as analyte specific reagents.
D13S272 D13S319 177Kb
Analytical and performance characteristics are not established. 100Kb
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Aquarius® Hematology
Cat. No. LPH 043-SA (50μl) Cat. No. LPH 043-A (100μl)
D13S25 Deletion The D13S25 probe, labeled in red, covers a 306Kb region including most of the DLEU7 gene, the telomeric end of the DLEU1 gene and the D13S25 marker. The probe mix also contains a control probe for 13qter (Clone 163C9) labeled in green. Probe Specification
D13S25, 13q14.3, Red 13qter, 13q34, Green
D13S25
13qter Chromosome 13
DLEU7
DLEU1
D13S25
RNASEH2B GUCY1B2
D13S294
306Kb
100Kb
Cat. No. LPH 024-SA (50μl) Cat. No. LPH 024-A (100μl)
Del (5q) Deletion The EGR1 probe, labeled in red, covers a 184Kb region within 5q31.2, including the D5S1701 and D5S500 markers. The probe mix also contains a control probe for chromosome 5 at 5p15.31, including the marker D5S630, labeled in green. Probe Specification
EGR1, 5q31.2, Red 5p15.31, Green EGR1
5p 15.31
Chromosome 5
TAS2R1 D5S630
CDC25C
EGR1 D5S1701 D5S500 D5S2415 D5S2542
D5S2064
These products are available as analyte specific reagents. 184Kb
310Kb 100Kb
18
Analytical and performance characteristics are not established.
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Aquarius® Hematology
Cat. No. LPH 025-SA (50μl) Cat. No. LPH 025-A (100μl)
Del (7q) Deletion The 7q22 probe, labeled in red, covers a 396Kb region including the telomeric end of the RELN gene and extending beyond the marker D7S658. The 7q31 probe, labeled in green, covers a 203Kb region including the TES gene. Probe Specification
7q22, Red 7q31, Green
7q22 7q31 Chromosome 7
RELN
ORC5L
TES
D7S658
D7S796
D7S2543 D7S2886 D7S486 203Kb 203Kb
396Kb 100Kb
Cat. No. LPH 020-SA (50μl) Cat. No. LPH 020-A (100μl)
Del (20q) Deletion The 20q12 probe, labeled in red, covers a 302Kb region within the PTPRT gene and includes the D20S108 marker. The 20q13.12 probes, labeled in green (139Kb and 174Kb), cover the MYBL2 gene and include the D20S150 marker. Probe Specification
20q12, Red 20q13.12, Green 20q12 20q13.12 Chromosome 20
PTPRT D20S591E
MYBL2 D20S150
D20S43
D20S108 D20S858
These products are available as analyte specific reagents. 302Kb
139Kb
174Kb
Analytical and performance characteristics are not established.
100Kb
19
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Aquarius® Hematology
Cat. No. LPH 019-SA (50μl) Cat. No. LPH 019-A (100μl)
E2A Breakapart The E2A product consists of a 189Kb probe, labeled in red, located centromeric to the E2A gene, including the RH98588 marker, and a green probe covering a 163Kb region located telomeric to the E2A gene, including the D19S883 marker. Probe Specification
E2A, 19p13, Red E2A, 19p13, Green
E2A Chromosome 19
E2A (TCF3)
RKHD1 D19S883
MBD3
RH98588
163Kb
189Kb 100Kb
Cat. No. LPH 036-SA (50μl) Cat. No. LPH 036-A (100μl)
EVI1 Breakapart The EVI1 product consists of a 156Kb probe, labeled in red, telomeric to the D3S4415 marker and including the LRRC34 gene, a green probe covering a 179Kb region, including the entire EVI1 gene and flanking regions and a blue probe, which covers 559Kb region centromeric to the EVI1 gene, including the D3S3364 marker. Probe Specification
EVI1, 3q26.2, Red EVI1, 3q26.2, Green EVI1, 3q26.2, Blue EVI1 Chromosome 3
EVI1 D3S3364
559Kb
D3S1614 D3S3809
MYNN LRRC34
D3S1282
D3S3523 D3S4415 156Kb
179Kb 100Kb
20
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
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Aquarius® Hematology
Cat. No. LPH 032-SA (50μl) Cat. No. LPH 032-A (100μl)
FIP1L1/CHIC2/PDGFRA Deletion/Fusion The FIP1L1/CHIC2/PDGFRA product consists of a 177Kb probe, labeled in green, located centromeric to the FIP1L1 gene, including the D4S1036 marker, a 174Kb probe, labeled in red covering the CHIC2 gene and a 174Kb probe, labeled in green, located telomeric to the PDGFRA gene, including the D4S956 marker. Probe Specification
FIP1L1, 4q12, Green CHIC2, 4q12, Red PDGFRA, 4q12, Green
FIP1L1/CHIC2/PDGFRA Chromosome 4
SCFD2 D4S1514 D4S1036
FIP1L1
LNX
CHIC2 PDGFRA
D4S461
D4S1394 D4S956 D4S1594 D4S1630
174Kb
177Kb
KIT D4S643
174Kb 100Kb
Cat. No. LPH 014-SA (50μl) Cat. No. LPH 014-A (100μl)
IGH Breakapart The IGH product consists of a 124Kb probe, labeled in red, covering the Constant region of the gene and a green probe, covering a 617Kb region within the Variable segment of the gene. Probe Specification
IGHC, 14q32.3, Red IGHV, 14q32.3, Green
IGH Chromosome 14
Variable Segment
Constant Segment J D IGHA2 IGHM IGHE IGHG3 D14S1007 IGHG4 IGHG1 IGHG2 IGHA1 IGHGP
124Kb
D14S1419 D14S1420 D14S308
These products are available as analyte specific reagents. 100Kb
617Kb
Analytical and performance characteristics are not established.
21
15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:17 Page 22
Aquarius® Hematology
Cat. No. LPH 018-SA (50μl) Cat. No. LPH 018-A (100μl)
IGH/BCL2 Translocation, Dual Fusion The IGH/BCL2 product consists of probes, labeled in green, covering the Constant, J, D and Variable segments of the IGH gene, and a 585Kb probe, labeled in red, covering the BCL2 and KDSR genes. Probe Specification
BCL2, 18q21, Red IGH, 14q32.3, Green
IGH Chromosome 14
Variable Segment
Constant Segment J D D14S1007
IGHA2 IGHM IGHE IGHG3 IGHG4 IGHG1 IGHG2 IGHA1 IGHGP 124Kb
D14S1419 D14S1420 D14S308
168Kb
617Kb
100Kb
BCL2 Chromosome 18
BCL2 D18S91 D18S1264
KDSR D18S51
D18S87 D18S1366
585Kb
100kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
22
15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:17 Page 23
Aquarius® Hematology
Cat. No. LPH 021-SA (50μl) Cat. No. LPH 021-A (100μl)
IGH/CCND1 Translocation, Dual Fusion The IGH/CCND1 product consists of probes, labeled in green, covering the Constant, J, D and Variable segments of the IGH gene, and CCND1 probes, labeled in red. The CCND1 probe mix contains a 155Kb probe centromeric to CCND1 gene, covering a region between the D11S2663 and the D11S4095 markers, and a second probe (159Kb) covering the telomeric end of CCND1 gene and the region up to FGF3 gene. Probe Specification
CCND1 (BCL1), 11q13, Red IGH, 14q32.3, Green
IGH Chromosome 14
Variable Segment
Constant Segment J D D14S1007
IGHA2 IGHM IGHE IGHG3 IGHG4 IGHG1 IGHG2 IGHA1 IGHGP
D14S1419 D14S1420 D14S308
168Kb
124Kb
617Kb
100Kb
CCND1 (BCL1) Chromosome 11
MYEOV D11S2663 D11S1100
CCND1
FGF19 FGF4 FGF3
D11S4095 D11S1076
D11S4381 D11S2927
159Kb
155Kb 100Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
23
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Aquarius® Hematology
Cat. No. LPH 040-SA (50μl) Cat. No. LPH 040-A (100μl)
IGH/CCND3 Translocation, Dual Fusion The IGH/CCND3 product consists of probes labeled in green, covering the Constant, J, D and Variable segments of the IGH gene, and CCND3 probes, labeled in red. The CCND3 probe mix contains a 158Kb probe telomeric to the CCND3 gene, including the D6S1017 marker and a second probe covering the 244Kb region centromeric to the TAF8 gene, including the D6S400 and the D6S1463 markers. Probe Specification
CCND3, 6p21, Red IGH, 14q32.3, Green
IGH Chromosome 14
Variable Segment
Constant Segment J D D14S1007
IGHA2 IGHM IGHE IGHG3 IGHG4 IGHG1 IGHG2 IGHA1 IGHGP 124Kb
D14S1419 D14S1420 D14S308
168Kb
617Kb
100Kb
CCND3 Chromosome 6
CCND3 D6S1017
TAF8 C6orf132 D6S400
D6S1463
244Kb
158Kb 100Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
24
15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:17 Page 25
Aquarius® Hematology
Cat. No. LPH 041-SA (50μl) Cat. No. LPH 041-A (100μl)
IGH/cMYC Translocation, Dual Fusion The IGH/cMYC product consists of probes, labeled in green, covering the Constant and Variable segments of the IGH gene, and cMYC probes, labeled in red. The cMYC probe mix contains a 220Kb probe centromeric to the cMYC gene and a second probe covering the 186Kb region telomeric to the cMYC gene, including the D8S1644 marker. Probe Specification
cMYC, 8q24.21, Red IGH, 14q32.3, Green
IGH Chromosome 14
Variable Segment
Constant Segment J D D14S1007
IGHA2 IGHM IGHE IGHG3 IGHG4 IGHG1 IGHG2 IGHA1 IGHGP
124Kb
D14S1419 D14S1420 D14S308
617Kb
100Kb
MYC Chromosome 8
POU5F1P1
MYC
D8S490 D8S1087 D8S1153 D8S1128 D8S1980 D8S1720
220Kb
D8S1644
186Kb 100Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
25
15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:17 Page 26
Aquarius® Hematology
Cat. No. LPH 030-SA (50μl) Cat. No. LPH 030-A (100μl)
IGH/FGFR3 Translocation, Dual Fusion The IGH/FGFR3 product consists of probes, labeled in green, covering the Constant, J, D and Variable segments of the IGH gene, and FGFR3 probes, labeled in red. The FGFR3 probe mix contains a 118Kb probe telomeric to FGFR3, including the D4S2561E marker and a second probe covering the 126Kb region centromeric to MMSET, including the D4S1182 marker. Probe Specification
FGFR3, 4p16.3, Red IGH, 14q32.3, Green
IGH Chromosome 14
Variable Segment
Constant Segment J D D14S1007
IGHA2 IGHM IGHE IGHG3 IGHG4 IGHG1 IGHG2 IGHA1 IGHGP
D14S1419 D14S1420 D14S308
168Kb
124Kb
617Kb
100Kb
FGFR3 Chromosome 4
FGFR3
WHSC2
LETM1 MMSET (WHSC1)
D4S168
D4S573 D4S166 D4S1182
D4S2561E
118Kb
D4S43
126Kb 100Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
26
15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:17 Page 27
Aquarius® Hematology
Cat. No. LPH 029-SA (50μl) Cat. No. LPH 029-A (100μl)
IGH/MAF Translocation, Dual Fusion The IGH/MAF product consists of probes, labeled in green, covering the Constant, J, D and Variable segments of the IGH gene, and c-MAF probes, labeled in red. The c-MAF probe mix contains two probes centromeric to the c-MAF gene (145Kb and 91Kb) covering part of the WWOX gene and includes the D16S3213 and the D16S3029 markers. The other two probes, telomeric to c-MAF cover 119Kb and 125Kb regions and include the RH69965 and the D16S3073 markers respectively. Probe Specification
MAF, 16q23, Red IGH, 14q32.3, Green
IGH Chromosome 14
Variable Segment
Constant Segment J D D14S1007
IGHA2 IGHM IGHE IGHG3 IGHG4 IGHG1 IGHG2 IGHA1 IGHGP 124Kb
D14S1419 D14S1420 D14S308
168Kb
617Kb
100Kb
MAF Chromosome 16
WWOX D16S2793 D16S518
D16S3213 D16S3029 D16S3324 145Kb
91Kb
MAF RH69965 D16S3073
119Kb 125Kb 100Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
27
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Aquarius® Hematology
Cat. No. LPH 044-SA (50μl) Cat. No. LPH 044-A (100μl)
IGH/MAFB Translocation, Dual Fusion The IGH/MAFB product consists of probes, labeled in green, covering the Constant and Variable segments of the IGH gene, and MAFB probes (195Kb, 161Kb and 289Kb), labeled in red. The MAFB probes are located on either side of the breakpoint region (between MAFB and TIMAP). Probe Specification
MAFB, 20q12, Red IGH, 14q32.3, Green
IGH Chromosome 14
Variable Segment
Constant Segment J D D14S1007
IGHA2 IGHM IGHE IGHG3 IGHG4 IGHG1 IGHG2 IGHA1 IGHGP
124Kb
D14S1419 D14S1420 D14S308
617Kb
100Kb
MAFB Chromosome 20
MAFB
TIMAP
195Kb
161Kb
TOP1 PLCG1
289Kb 100Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
28
15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:17 Page 29
Aquarius® Hematology
Cat. No. LPH 045-SA (50μl) Cat. No. LPH 045-A (100μl)
IGH/MYEOV Translocation, Dual Fusion The IGH/MYEOV product consists of probes, labeled in green, covering the Constant and Variable segments of the IGH gene, and MYEOV probes, labeled in red. The MYEOV probe mix contains a 155Kb probe centromeric to the MYEOV gene, which includes the TPCN2 gene and a second probe, telomeric to the MYEOV gene, covering the 162Kb region including the CCND1 and ORAOV1 genes. Probe Specification
MYEOV, 11q13, Red IGH, 14q32.3, Green
IGH Chromosome 14
Variable Segment
Constant Segment J D D14S1007
IGHA2 IGHM IGHE IGHG3 IGHG4 IGHG1 IGHG2 IGHA1 IGHGP
124Kb
D14S1419 D14S1420 D14S308
617Kb
100Kb
MYEOV Chromosome 11
TPCN2
D11S2663 D11S1100
D11S4113
ORAOV1 CCND1 FGF4 FGF3
MYEOV
155Kb
D11S4095 D11S1076
D11S4381
162Kb 100Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
29
15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:17 Page 30
Aquarius® Hematology
Cat. No. LPH 033-SA (50μl) Cat. No. LPH 033-A (100μl)
IGL Breakapart The IGL product consists of a 278Kb probe, labeled in red, centromeric to the IGL Variable region and covering the MAPK1 gene, and a green probe, covering a 307Kb region telomeric to the IGL Constant segment, including the BCR gene. Probe Specification
IGL, 22q11.2, Red IGL, 22q11.2, Green IGL Chromosome 22
IGLV
MAPK1
IGLC
BCR
D22S446 D22S1264 D22S1003E
307Kb
278Kb
100Kb
Cat. No. LPH 034-SA (50μl) Cat. No. LPH 034-A (100μl)
IGK Breakapart The IGK product consists of a 183Kb probe, labeled in red, covering a part of the distal IGK Variable region and a green probe, covering a 606Kb region telomeric to the Joining segments and the Constant segment of IGK, between the D2S2216 and D2S2510 markers. Probe Specification
IGK, 2p11.2, Red IGK, 2p11.2, Green
IGK Chromosome 2
CJ D2S2216 D2S2610
IGK Variable Regions Proximal
D2S1994 D2S2510
606Kb
183Kb 100Kb
30
Distal
D21S1241
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:17 Page 31
Aquarius® Hematology
Cat. No. LPH 013-SA (50μl) Cat. No. LPH 013-A (100μl)
MLL Breakapart The MLL product consists of an 87Kb probe, labeled in red, covering a region telomeric to the MLL gene including the marker D11S3207 and a green probe covering a 168Kb region centromeric to the MLL gene spanning the CD3G and UBE4A genes. Probe Specification
MLL, 11q23, Red MLL, 11q23, Green
MLL Chromosome 11
CD3G UBE4A
MLL
D11S1374 D11S1933 D11S3222
PHLDB1
D11S3207
87Kb
168Kb 100Kb
Cat. No. LPH 016-SA (50μl) Cat. No. LPH 016-A (100μl)
MYB Deletion The MYB probe is 183Kb, labeled in red, covers the entire MYB gene and a region telomeric to the gene, 137Kb beyond the marker AFMA074ZG9. The probe mix also contains a control probe for the 6 centromere (D6Z1) labeled in green. Probe Specification
D6Z1
MYB, 6q23, Red D6Z1, 6p11.1-q11.1, Green
MYB Chromosome 6
MYB AFMA074ZG9
D6S1837 D6S1431
183Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
100Kb
31
15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:17 Page 32
Aquarius® Hematology
Cat. No. LPH 009-SA (50μl) Cat. No. LPH 009-A (100μl)
P16 Deletion The P16 probe, labeled in red, covers a 193Kb region of 9p21, extending from 105Kb telomeric of P16 gene to 46Kb centromeric of CDKN2B. The probe mix also contains a control probe for chromosome 9 (D9Z3, the heterochromatic block at 9q12) labeled in green. Probe Specification
P16, 9p21, Red D9Z3, 9q12, Green D9Z3
P16
Chromosome 9
P16 (CDKN2A) CDKN2B D9S2060 D9S974 D9S1605 D9S1604 D9S1748 193Kb
100kb
Cat. No. LPH 017-SA (50μl) Cat. No. LPH 017-A (100μl)
P53 Deletion The P53 probe is 159Kb, labeled in red, covers the whole P53 gene, extending 66Kb telomeric to the gene and covering a region centromeric to the gene, to just beyond the marker D17S655. The probe mix also contains a control probe for the 17 centromere (D17Z1) labeled in green. Probe Specification
P53, 17p13, Red D17Z1, 17p11.1-q11.1, Green
P53 D17Z1 Chromosome 17
P53 D17S1678
EFNB3 D17S1353 D17S655
These products are available as analyte specific reagents.
159Kb 100Kb
32
Analytical and performance characteristics are not established.
15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:17 Page 33
Aquarius® Hematology
Cat. No. LPH 052-SA (50μl) Cat. No. LPH 052-A (100μl)
P53/ATM Probe Combination The P53 probe is 159Kb, labeled in red and covers the whole P53 gene, extends 66Kb telomeric to the gene and covers a region centromeric to the gene, to just beyond the marker D17S655. The ATM probe is 180Kb, labeled in green, and covers the telomeric end of NPAT gene and the centromeric end of the ATM gene to just beyond the D11S3347 marker. Probe Specification
P53, 17p13, Red ATM, 11q22.3, Green
P53 Chromosome 17
P53 D17S1678
EFNB3 D17S1353 D17S655
159Kb 100Kb
ATM Chromosome 11
NPAT
ATM D11S3347 D11S2179
180Kb 100Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
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Aquarius® Hematology
Cat. No. LPH 031-SA (50μl) Cat. No. LPH 031-A (100μl)
PDGFRB Breakapart The PDGFRB product consists of a 107Kb probe, labeled in red, located centromeric to the PDGFRB gene, including the D5S2618 and D5S2619 markers and a green probe, covering a 154Kb region telomeric to the PDGFRB gene, including the D5S2015 marker. Probe Specification
PDGFRB, 5q32, Red PDGFRB, 5q32, Green
PDGFRB Chromosome 5
CSF1R D5S2618
PDGFRB
D5S2619
D5S2015
154Kb
107Kb 100Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
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Aquarius® Hematology
Cat. No. LPH 023-SA (50μl) Cat. No. LPH 023-A (100μl)
PML/RARα Translocation, Dual Fusion The PML probe mix, labeled in red, consists of a 151Kb probe centromeric to the PML gene and a 174Kb probe telomeric to the PML gene. The RARα probe mix, labeled in green, consists of a 167Kb probe centromeric to the RARα gene, including the CASC3 gene, and a 164Kb probe including the telomeric end of the RARα gene as well as the TOP2A and IGFBP4 genes. Probe Specification
PML, 15q24.1, Red RARα, 17q21, Green
PML Chromosome 15
PML D15S188
D15S818 D15S160 D15S965 D15S169 D15S1326 D15S624E D15S1281 174Kb
151Kb 100Kb
RAR α Chromosome 17
CASC3
CDC6
RARα
TOP2A IGFBP4
D17S1423E D17S1984
167Kb
164Kb 100Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
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Aquarius® Hematology
Cat. No. LPH 046-SA (50μl) Cat. No. LPH 046-A (100μl)
TCL1 Breakapart The TCL1 product consists of a 138Kb probe, labeled in red, located centromeric to the TCL1A and TCL1B genes, including the GLRX5 gene and the D14S62 marker, and a green probe covering a 124Kb region located telomeric to these genes, including the D14S131 marker. Probe Specification
TCL1, 14q32.13, Red TCL1, 14q32.13, Green
TCL1 Chromosome 14
GLRX5
TCL1A TCL1B TCL6
D14S62
D14S131
124Kb
138Kb 100Kb
Cat. No. LPH 047-SA (50μl) Cat. No. LPH 047-A (100μl)
TCRAD Breakapart The TCRAD product consists of a 225Kb probe, labeled in red, located at the centromeric end of the Variable Region of the immunoglobulin gene cluster, including the G36107 marker and a green probe covering a 143Kb region located telomeric to the TRAC gene, including the entire OXA1L gene and the G35927 marker. Probe Specification
TCRAD, 14q11.2, Red TCRAD, 14q11.2, Green
TCRAD Chromosome 14
TRAC
TOX4 SALL2 IGV Region G36107
OXA1L G35927 143Kb
225Kb
100Kb
36
DAD1 ABHD4 IGD IGJ IGC Region
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:17 Page 37
Aquarius® Hematology
Cat. No. LPH 048-SA (50μl) Cat. No. LPH 048-A (100μl)
TCRB Breakapart The TCRB product consists of a 177kb probe, labeled in red, covering the centromeric end of the TRB gene, including the D7S2473 marker and a green probe covering a 133Kb region located telomeric to the TRB gene, including the SHGC-81465 marker. Probe Specification
TCRB, 7q34, Red TCRB, 7q34, Green
TCRB Chromosome 7
TRB D7S2473
PRSS1
IGV Region
177Kb
IGJ IGC Region
EPHB6 SHGC-81465
133Kb 100Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
37
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Aquarius® Hematology
Cat. No. LPH 012-SA (50μl) Cat. No. LPH 012-A (100μl)
TEL/AML1 Translocation, Dual Fusion The TEL1 probe mix, labeled in red, contains a probe covering a 180Kb region between the markers D12S845 and D12S89 and a second probe centromeric to the TEL1 (ETV6) gene, extending 168Kb from the marker D12S1898. For AML1, there are two probes, labeled in green, one covering a 148Kb region centromeric to the AML1 (RUNX1) gene, including the CLIC6 gene and a second probe covering a 167Kb region, including the markers D21S1895 and D21S1921. Probe Specification
TEL1, 12p13.2, Red AML1, 21q22.12, Green
TEL1 Chromosome 12
TEL1 (ETV6) D12S827 D12S845 D12S1095 D12S89 D12S1697
D12S98 D12S850 D12S1898
180Kb
168Kb 100Kb
AML1 Chromosome 21
DSCR1
CLIC6
AML1 (RUNX1) D21S326 D21S1706 D21S1895 D21S393 D21S1969 D21S1921
167Kb
148Kb 100Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
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Aquarius® Hematology
Cat. No. LPH 049-SA (50μl) Cat. No. LPH 049-A (100μl)
TLX1 Breakapart The TLX1 product consists of a 179Kb probe, labeled in red, located centromeric to the TLX1 gene, including the KAZALD1 gene and the D10S1629 marker and a green probe covering a 124Kb region located telomeric to the gene, including the LBX1 gene and the RH92279 marker. Probe Specification
TLX1, 10q24, Red TLX1, 10q24, Green
TLX1 Chromosome 10
SFXN3 PDZD7 TLX1 LZTS2 KAZALD1 D10S1629
LBX1 WI-19473 RH92279
124Kb
179Kb 100Kb
Cat. No. LPH 050-SA (50μl) Cat. No. LPH 050-A (100μl)
TLX3 Breakapart The TLX3 product consists of a 162Kb probe, labeled in red, located centromeric to the TLX3 gene, including the middle part of the RANBP17 gene and the D5S653 marker and a green probe covering a 173Kb region located telomeric to the gene, including the NPM1 and FGF18 genes and the RH80894 marker. Probe Specification
TLX3, 5q35, Red TLX3, 5q35, Green TLX3 Chromosome 5
TLX3
RANBP17 D5S653
NPM1 FGF18 RH80894
These products are available as analyte specific reagents. 162Kb
173Kb
Analytical and performance characteristics are not established.
100Kb
39
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Aquarius® Hematology
Cat. No. LPH CLL-SA (5x50μl) Cat. No. LPH CLL-A (5x100μl)
Aquarius® Hematology Panel Chromosome 12 Enumeration probe The Chromosome 12 Alpha Satellite Probe is a repeat sequence probe, labeled in red, which recognizes the centromeric repeat sequence D12Z3.
13q14.3 The 13q14.3 probe, labeled in red, is approximately 600Kb and covers the region between the D13S319 and D13S25 markers. The probe mix also contains a control probe for 13qter (Clone 163C9) labeled in green.
P53 (17p13) The P53 probe is 159Kb labeled in red, covers the whole P53 gene, extending 66Kb telomeric to the gene and covering a region centromeric to the gene, to just beyond the marker D17S655. The probe mix also contains a control probe for the 17 centromere (D17Z1) labeled in green.
ATM (11q22.3) The ATM probe is 180Kb, labeled in red, and covers the telomeric end of the NPAT gene and the centromeric end of the ATM gene to just beyond the D11S3347 marker. The probe mix also contains a control probe for the 11 centromere (D11Z1) labeled in green.
MYB (6q23) The MYB probe is 183Kb, labeled in red, covers the entire MYB gene and a region telomeric to the gene, 137Kb beyond the marker AFMA074ZG9. The probe mix also contains a control probe for the 6 centromere (D6Z1) labeled in green.
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
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Aquarius速 Pathology
Pathology
15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:18 Page 42
Aquarius® Pathology
Contents 43
Tissue Pretreatment Kit
44
ALK Breakapart
44
CHOP Breakapart
45
C-MET Amplification
45
EGFR Amplification
46
EML4 Breakpart
46
EWSR1 Breakapart
47
EWSR1/ERG Translocation, Dual Fusion
48
FLI1/EWSR1 Translocation, Dual Fusion
49
FGFR1 Breakapart/Amplification
49
HER2 Amplification
50
MALT1 Breakapart
50
MDM2 Amplification
51
N-MYC Amplification
51
PAX3 Breakapart
52
PAX7 Breakapart
52
RB1 Deletion
53
SRD (CHD5) Deletion
53
SYT Breakapart
54
TMPRSS2 Breakapart
54
ERG Control
55
TOP2A Amplification/Deletion
55
ZNF217 Amplification
42
Pathology Cytocell offers a range of Pathology probes available in the Aquarius® liquid format. These probes are directly labeled, ready to use in hybridization buffer and available in an economical 50 and larger 100µl volumes.
15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:18 Page 43
Cat. No. LPS 100
Tissue Pretreatment Kit Aquarius速 Pathology
Introducing the first Pretreatment kit capable of preparing slides for CISH and/or FISH analysis on Formalin-Fixed, Paraffin-Embedded (FFPE) tissue. Our ready-to-use Tissue Pretreatment Kit has been optimized to produce excellent visual results with our extensive Aquarius速 Pathology FISH range. To further extend the utility of the kit we have also validated its use with other commercially available CISH (Chromogenic In Situ hybridization) and FISH (Fluorescence In Situ hybridization) DNA probes*. With ease-of-use and convenience in mind, our simple two stage FFPE slide preparation protocol employs the use of ready-to-use reagents; which have been optimized to increase the permeabilization of cell membranes and facilitate penetration of the desired FISH or CISH DNA probe.
Product Information 速
Aquarius Tissue Pretreatment Kit**
Kit Components Reagent 1 (1x1L) Reagent 2 (1x10mL)
*A list of manufacturers is available upon request. **This product is provided under an agreement between Life Technologies Corporation and Cytocell Ltd and is available for life science use only.
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15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:18 Page 44
Cat. No. LPS 019-SA (50μl) Cat. No. LPS 019-A
(100μl)
Aquarius® Pathology
ALK Breakapart The ALK Breakapart probe consists of a green 420Kb probe, which spans the majority of the ALK gene and a red 486Kb probe, which is telomeric to the ALK gene. Probe Specification
ALK, 2p23, Red ALK, 2p23, Green
ALK Chromosome 2
ALK
D2S2312
D2S2383
D2S2934 D2S405 420Kb
486Kb
100Kb
Cat. No. LPS 015-SA (50μl) Cat. No. LPS 015-A
(100μl)
CHOP Breakapart The CHOP Breakapart probe consists of a green 145Kb probe and a red 146Kb probe, which are positioned on each side of the CHOP gene. Probe Specification
CHOP, 12q13, Red CHOP, 12q13, Green
CHOP Chromosome 12
CHOP (DDIT3) GLI1
R3HDM2 D12S1266
D12S1934
MARS
MBD6 KIF5A
D12S1943
D12S2159 D12S1889
D12S1969
145Kb
146Kb 100Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
44
15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:18 Page 45
Cat. No. LPS 004-SA (50μl) Cat. No. LPS 004-A
(100μl)
C-MET Amplification Aquarius® Pathology
The C-MET Amplification probe consists of a 278Kb red probe spanning the C-MET gene. The centromeric probe in green acts as a control for chromosome 7. Probe Specification
C-MET, 7q31, Red D7Z1, 7p11.1-q11.1, Green
C-MET
D7Z1
Chromosome 7
MET D7S1402
D7S2877
CAPZA2
D7S2460 D7S1764 D7S2863
D7S1599
278Kb 100Kb
Cat. No. LPS 003-SA (50μl) Cat. No. LPS 003-A
(100μl)
EGFR Amplification The EGFR Amplification probe consists of a red 295Kb probe spanning the gene region 7p11.2. The centromeric probe in green acts as a control for chromosome 7. Probe Specification
EGFR, 7p11.2, Red D7Z1, 7p11.1-q11.1, Green
EGFR D7Z1 Chromosome 7
EGFR D7S793
D7S2357
D7S1988
D7S2935
295Kb 100Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
45
15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:18 Page 46
Cat. No. LPS 020-SA (50μl) Cat. No. LPS 020-A
(100μl)
Aquarius® Pathology
EML4 Breakapart The EML4 Breakapart probe consists of a green 406Kb probe and a red 353Kb probe, which are positioned on each side of the EML4 gene. Probe Specification
EML4, 2p21, Red EML4, 2p21, Green
EML4 Chromosome 2
EML4 D2S2306
SHGC-106023
RH94235
RH120737
406Kb
353Kb 100Kb
Cat. No. LPS 006-SA (50μl) Cat. No. LPS 006-A
(100μl)
EWSR1 Breakapart The EWSR1 Breakapart probe contains a red 392Kb probe and a green 631Kb probe, which are positioned on each side of the EWSR1 gene. Probe Specification
EWSR1, 22q12, Red EWSR1, 22q12, Green EWSR1 Chromosome 22
EWSR1 RH47619
RASL10A
D22S991E D22S448
D22S590
392Kb
D22S973E
631Kb 100Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
46
15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:18 Page 47
Cat. No. LPS 008-SA (50μl) Cat. No. LPS 008-A
(100μl)
Aquarius® Pathology
EWSR1/ERG Translocation, Dual Fusion The EWSR1/ERG Translocation probe consists of green probes (215Kb, 154Kb) flanking the breakpoint region at the ERG gene locus and red probes (139Kb, 151Kb) flanking the breakpoint region at the EWSR1 locus. Probe Specification
EWSR1, 22q12, Red ERG, 21q22, Green
EWSR1 Chromosome 22
EWSR1
RASL10A
D22S991E D22S448
D22S590
139Kb
151Kb 100Kb
ERG Chromosome 21
ERG
KCNJ15 D21S339
D21S1809 D21S338
ETS2 D21S1836
D21S1959 D21S1956
154Kb
215Kb 100Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
47
15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:18 Page 48
Cat. No. LPS 007-SA (50μl) Cat. No. LPS 007-A
(100μl)
Aquarius® Pathology
FLI1/EWSR1 Translocation, Dual Fusion The FLI1/EWSR1 Translocation probe consists of green probes (139Kb, 151Kb) flanking the breakpoint region at the EWSR1 gene locus and red probes (94Kb, 79Kb) flanking the breakpoint region at the FLI1 locus. Probe Specification
FLI1, 11q24, Red EWSR1, 22q12 Green
FLI1 Chromosome 11
FLI1
ETS1 D11S4369 D11S1017
KCNJ1
D11S912
D11S3491 D11S4150 D11S3463 D11S4123
79Kb
94Kb 100Kb
EWSR1 Chromosome 22
EWSR1
RASL10A
D22S991E D22S448
D22S590
139Kb
151Kb 100Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
48
15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:18 Page 49
Cat. No. LPS 018-SA (50μl) Cat. No. LPS 018-A
(100μl)
FGFR1 Breakapart/Amplification Aquarius® Pathology
The FGFR1 Breakapart/Amplification probe consists of a green 267Kb probe and a red 272Kb probe which are positioned on each side of the FGFR1 gene. The 8-centromere probe in blue acts as a control for chromosome 8. Probe Specification
FGFR1, 8p12, Red FGFR1, 8p12, Green D8Z2, 8p11.1-q11.1, Blue
FGFR1 D8Z2 Chromosome 8
LETM2
FGFR1
D8S135
D8S2317
D8S389
267Kb
272Kb 100Kb
Cat. No. LPS 001-SA (50μl) Cat. No. LPS 001-A
(100μl)
HER2 Amplification The HER2 Amplification probe consists of a 347Kb probe labeled in red, spanning the HER2 gene and neighboring regions. Probe Specification
ERBB2 (HER2), 17q12, Red
ERBB2 (Her2) Chromosome 17
(Amplified HER2)
PERLD1
ERBB2 GRB7 D17S2147 D17S754
D17S1215
These products are available as analyte specific reagents. 347Kb
Analytical and performance characteristics are not established.
100Kb
49
15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:18 Page 50
Cat. No. LPS 017-SA (50μl) Cat. No. LPS 017-A
(100μl)
Aquarius® Pathology
MALT1 Breakapart The MALT1 Breakapart probe consists of a green 524Kb probe and a red 424Kb probe, which are positioned on each side of the MALT1 gene. Probe Specification
MALT1, 18q21, Red MALT1, 18q21, Green
MALT Chromosome 18
MALT1 D18S1333 D18S881 D18S1117 D18S531 D18S1265 D18S1129 D18S887 524Kb
424Kb 100Kb
Cat. No. LPS 016-SA (50μl) Cat. No. LPS 016-A
(100μl)
MDM2 Amplification The MDM2 Amplification probe consists of a red 146Kb probe spanning the gene region 12q15 and neighboring CPM gene. The centromeric probe in green acts as a control for chromosome 12. Probe Specification
MDM2, 12q15, Red D12Z1, 12p11.1-q11.1, Green
D12Z1 MDM2 Chromosome 12
NUP107
MDM2
CPM D12S1501
146Kb 100Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
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15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:18 Page 51
Cat. No. LPS 009-SA (50μl) Cat. No. LPS 009-A
(100μl)
N-MYC Amplification Aquarius® Pathology
The N-MYC Amplification probe consists of a red 140Kb probe spanning the gene region 2p24.3. The LAF gene probe in green at 2q11 acts as a control for chromosome 2. Probe Specification
MYCN
N-MYC, 2p24.3, Red LAF, 2q11, Green
LAF Chromosome 2
MYCN
AFF3
D2S2719 RH17899
D2S2710
140Kb
201Kb 100Kb
Cat. No. LPS 012-SA (50μl) Cat. No. LPS 012-A
(100μl)
PAX3 Breakapart The PAX3 Breakapart probe consists of a green 168Kb probe and a red 124Kb probe, which are positioned on each side of the PAX3 gene. Probe Specification
PAX3, 2q35, Red PAX3, 2q35, Green
PAX3 Chromosome 2
PAX3 D2S102
D2S313 D2S2599
D2S2300
168Kb
124Kb 100Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
51
15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:18 Page 52
Cat. No. LPS 013-SA (50μl) Cat. No. LPS 013-A
(100μl)
Aquarius® Pathology
PAX7 Breakapart The PAX7 Breakapart probe consists of a green 109Kb probe and a red 139Kb probe, which are positioned on each side of the PAX7 gene. Probe Specification
PAX7, 1p36, Red PAX7, 1p36, Green
PAX7 Chromosome 1
IGSF21
PAX7
KLHDC7A
TASIR2
D1S2598
D1S1345
D1S3604 D1S1524 D1S2644 D1S1324
109Kb
139Kb 100Kb
Cat. No. LPS 011-SA (50μl) Cat. No. LPS 011-A
(100μl)
RB1 Deletion The RB1 Deletion probe consists of a 262Kb red probe spanning the RB1 gene region. The 13qter probe in green acts as a control for chromosome 13. Probe Specification
RB1, 13q14.2, Red 13qter, 13q34, Green
RB1
13qter Chromosome 13
RB1 D13S645
D13S153
D13S1211E
D13S818
262Kb 100Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
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15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:18 Page 53
Cat. No. LPS 010-SA (50μl) Cat. No. LPS 010-A
(100μl)
SRD (CHD5) Deletion Aquarius® Pathology
The SRD (CHD5) Deletion probe consists of a 210Kb red probe spanning the SRD (CHD5) gene region. The 1qter probe in green acts as a control for chromosome 1. Probe Specification
SRD (CHD5), 1p36, Red 1qter, 1q44, Green 1qter
SRD
Chromosome 1
SRD
KCNAB2 D1S1323
(CHD5) D1S286E
D1S83
D1S2870 D1S2531
D1S1250
210Kb 100Kb
Cat. No. LPS 014-SA (50μl) Cat. No. LPS 014-A
(100μl)
SYT Breakapart The SYT Breakapart probe consists of a green 151Kb probe and a red 148Kb probe, which are positioned on each side of the SYT gene. Probe Specification
SYT, 18q11.2, Red SYT, 18q11.2, Green
SYT Chromosome 18
SYT D18S1359
(SS18)
SGC35446
148Kb
TAF4B PMC303366P3
151Kb 100Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
53
15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:18 Page 54
Cat. No. LPS 098-SA (25μl) Cat. No. LPS 098-A
(50μl)
Aquarius® Pathology
TMPRSS2 Breakapart The TMPRSS2 Breakapart probe consists of two green 235Kb and 392Kb probes and a red 541Kb probe, which are positioned on each side of the TMPRSS2 gene. Probe Specification
TMPRSS2, 21q22.3, Red TMPRSS2, 21q22.3, Green TMPRSS2 Chromosome 21
TMPRSS2 D21S1906
D21S1260
235Kb
D21S1863
D21S1838
541Kb
392Kb 100Kb
Cat. No. LPS 099-SA (25μl) Cat. No. LPS 099-A
(50μl)
ERG Control The ERG Control probe consists of three blue 288Kb, 106Kb and 215Kb probes that cover the telomeric region of the ERG gene up to the D21S1439 marker. Probe Specification
ERG, 21q22.2, Blue
ERG Chromosome 21
ERG D21S1439
ETS2
SHGC-11427
288Kb
106Kb
215Kb 100Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
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15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:18 Page 55
Cat. No. LPS 002-SA (50μl) Cat. No. LPS 002-A
(100μl)
TOP2A Amplification/Deletion Aquarius® Pathology
The TOP2A Amplification/Deletion probe consists of a red 164Kb probe spanning the TOP2A gene region. The centromeric probe in green acts as a control for chromosome 17. Probe Specification
TOP2A, 17q21, Red D17Z1, 17p11.1-q11.1, Green
D17Z1 TOP2A Chromosome 17
TOP2A D17S1335
D17S1230
164Kb 100Kb
Cat. No. LPS 005-SA (50μl) Cat. No. LPS 005-A
(100μl)
ZNF217 Amplification The ZNF217 Amplification probe consists of a 245Kb red probe spanning the ZNF217 gene and neighboring regions. The accompanying 20pter probe in green acts as a control for chromosome 20. Probe Specification
ZNF217, 20q13, Red 20pter, 20p13, Green
20pter ZNF217 Chromosome 20
ZNF217 D20S183
D20S840
D20S211
245Kb 100Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
55
Aquarius速 Pathology
15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:18 Page 56
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Aquarius速 Microdeletion
Microdeletion
15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:18 Page 58
Aquarius® Microdeletion
Contents 59
Alagille (JAG1) Region
59
Angelman (UBE3A/D15S10) Region
60
CHARGE Region
61
Cri-Du-Chat Region/SOTOS Region
62
DiGeorge II (10p14)
63
DiGeorge/VCFS TUPLE1 Region & 22q13.3 Region
64
DiGeorge/VCFS N25 Region & 22q13.3 Region
65
DiGeorge TBX1 Region & 22q13.3 Region
66
Kallmann (KAL1) Region/STS Region
67
Langer-Giedion Region
67
Monosomy 1p36 Region
68
Neurofibromatosis Type 1 Region
68
Prader-Willi/Angelman (SNRPN) Region
69
Rubinstein-Taybi Region
70
Saethre-Chotzen Region/ Williams-Beuren Region
71
SHOX
72
Smith-Magenis (FLII) Region/ Miller-Dieker Region
73
Smith-Magenis (RAI1) Region/ Miller-Dieker Region
74
SRY
74
Williams-Beuren Region
75
Wolf-Hirschhorn Region
76
XIST
58
Microdeletion Cytocell offers a range of Microdeletion probes available in the Aquarius® liquid format. These probes are directly labeled, ready to use in hybridization buffer and available in an economical 50 and larger 100µl volumes.
15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:18 Page 59
Cat. No. LPU 012-SA (50μl) Cat. No. LPU 012-A (100μl)
Alagille (JAG1) Region The JAG1 probe is 124Kb, labeled in red, and covers the entire JAG1 gene and flanking DNA, including the D20S1091 and D20S894 markers. The probe mix also contains a control probe for 20qter (Clone 81F12) labeled in green. Probe Specification
Aquarius® Microdeletion
Alagille
JAG1, 20p12, Red 20qter, 20q13.33, Green
20qter Chromosome 20
JAG1 D20S507 D20S160
D20S1091
D20S894
124Kb 100Kb
Cat. No. LPU 006-SA (50μl) Cat. No. LPU 006-A (100μl)
Angelman (UBE3A/D15S10) Region The Angelman (UBE3A/D15S10) probe is 108Kb, labeled in red, and covers most of the UBE3A gene and includes the D15S10 marker. The probe mix also contains a control probe for 15qter (Clone 154P1) labeled in green. Probe Specification
UBE3A, 15q11-13, Red 15qter, 15q26.3, Green UBE3A
15qter Chromosome 15
Angelman Syndrome Region
UBE3A
SNRPN D15S63
PAR5
IPW PAR1
GABRB3
These products are available as analyte specific reagents.
D15S10
Analytical and performance characteristics are not established. 108Kb 100Kb
59
15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:18 Page 60
Cat. No. LPU 021-SA (50μl) Cat. No. LPU 021-A (100μl)
CHARGE Region The CHD7 probe is 310Kb, labeled in red, and covers a region including the entire CHD7 gene as well as the D8S1929 and D8S260 markers. The probe mix also contains a control probe for the 8 centromere (D8Z2) labeled in green.
Aquarius® Microdeletion
Probe Specification
CHD7, 8q12.1-q12.2, Red D8Z2, 8p11.1-q11.1, Green
D8Z2 CHARGE Chromosome 8
CHD7
RAB2 D8S1929
D8S2048
D8S1986
D8S260
310Kb 100Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
60
15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:18 Page 61
Cat. No. LPU 013-SA (50μl) Cat. No. LPU 013-A (100μl)
Cri-Du-Chat Region/SOTOS Region
Probe Specification
Aquarius® Microdeletion
The CTNND2 probe is 159Kb, labeled in red, and covers a region including the D5S2883 marker. The FLJ25076 probe is 193Kb, labeled in green, and covers a region including the D5S1637E and D5S2678 markers, as well as the entire FLJ25076 gene. The SOTOS probe is 167Kb, labeled in green, and covers the NSD1 gene. Cri-Du-Chat (CTNND2), 5p15.2, Red Cri-Du-Chat (FLJ25076), 5p15.31, Green SOTOS, 5q35, Green
SOTOS
Cri-Du-Chat
Chromosome 5
FLJ25076
NSUN2
FGFR4
D5S1637E D5S2678
D5S2703 D5S2630
NSD1 RGS14 D5S2281E D5S2260E D5S2221E
167Kb
193Kb
CTNND2 D5S2883
100Kb
159Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
61
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Cat. No. LPU 015-SA (50μl) Cat. No. LPU 015-A (100μl)
DiGeorge II (10p14) The CUGBP2 (BRUNOL3) probe is 144Kb, labeled in red, and covers a region including the D10S2196, D10S2420 and D10S1364E markers. The probe mix also contains a control probe for the 10 centromere (D10Z1) labeled in green. CUGBP2 (BRUNOL3), 10p14, Red D10Z1, 10p11.1-q11.1, Green
Aquarius® Microdeletion
Probe Specification
DiGeorge II D10Z1 Chromosome 10
CUGBP2 (BRUNOL3) D10S2393
D10S2235
D10S2196
D10S1632
D10S1364E D10S2420 100Kb
144Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
62
15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:18 Page 63
Cat. No. LPU 004-SA (50μl) Cat. No. LPU 004-A (100μl)
DiGeorge/VCFS TUPLE1 Region & 22q13.3 Region The TUPLE1 probe is 113Kb, labeled in red, and covers a region telomeric to the TUPLE1 gene including the UFD1L and CDC45L genes. The N85A3 (44Kb) probe, labeled in green, is located within 22q13.3 band and covers the telomeric end of SHANK3 gene. Aquarius® Microdeletion
Probe Specification
TUPLE1, 22q11.21, Red N85A3, 22q13.3, Green
TUPLE1
N85A3 Chromosome 22
TUPLE1 (HIRA) DGCR6
DGCR14 DGCR2
UFD1L
CLTCL1
SHANK3 RABL2B
CDC45L
D22S75 D22S1095E D22S451
D22S944
113Kb
ARSA
ACR
Telomere
D22S1254
44Kb 100Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
63
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Cat. No. LPU 010-SA (50μl) Cat. No. LPU 010-A (100μl)
DiGeorge/VCFS N25 Region & 22q13.3 Region
Aquarius® Microdeletion
The N25 probe is 63Kb, labeled in red, and covers a region including the D22S75 marker and the centromeric end of the CLTCL1 gene. The N85A3 (44Kb) probe, labeled in green, is located within 22q13.3 band and covers the telomeric end of the SHANK3 gene. Probe Specification
N25, 22q11.21, Red N85A3, 22q13.3, Green
N25 N85A3 Chromosome 22
N25 (D22S75) DGCR6
DGCR14 DGCR2
CLTCL1
HIRA UFD1L
SHANK3 RABL2B
CDC45L
D22S75 D22S1095E D22S451
D22S944
63Kb
ARSA
ACR
Telomere
44Kb 100Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
64
15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:18 Page 65
Cat. No. LPU 014-SA (50μl) Cat. No. LPU 014-A (100μl)
DiGeorge TBX1 Region & 22q13.3 Region The TBX1 probe is 211Kb, labeled in red, covers the entire TBX1 gene and includes the D22S1627 marker. The N85A3 (44Kb) probe, labeled in green, is located within 22q13.3 band and covers the telomeric end of the SHANK3 gene. Aquarius® Microdeletion
Probe Specification
TBX1, 22q11.21, Red N85A3, 22q13.3, Green
TBX1
N85A3 Chromosome 22
TBX1
HIRA (TUPLE1) UFD1L
SEPT5 GNB1L
CDC45L
D22S1637 D22S1627
DGCR8
SHANK3 RABL2B ARSA
D22S1662
211Kb
ACR
Telomere
44Kb 100Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
65
15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:18 Page 66
Cat. No. LPU 016-SA (50μl) Cat. No. LPU 016-A (100μl)
Kallmann (KAL1) Region/ STS Region
Aquarius® Microdeletion
The KAL1 probe is 334Kb, labeled in red, covers the entire KAL1 gene and includes the DXS278 and DXS7053 markers. The STS probe is 282Kb, labeled in green and covers the STS gene and most of the HDHD1A gene. The probe mix also contains a control probe for the X centromere (DXZ1) labeled in green. Probe Specification
KAL1, Xp22.31, Red STS, Xp22.31, Green DXZ1, Xp11.1-q11.1, Green
Kallmann Steroid Sulphatase DXZ1 X Chromosome
HDHD1A
STS
KAL1
DXS7731
DXS7500 DXS7965 DXS6767 282Kb
FAM9A
DXS7053 DXS7470 DXS7714 DXS278
100Kb
334Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
66
15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:18 Page 67
Cat. No. LPU 022-SA (50μl) Cat. No. LPU 022-A (100μl)
Langer-Giedion Region The TRPS1 probe mix, labeled in red, consists of two non-overlapping clones, 115Kb and 131Kb. The probes cover most of the TRPS1 gene and include the D8S565 marker. The EXT1 probe mix, labeled in green, consists of two non-overlapping clones (165Kb and 206Kb) and covers the EXT1 deletion region. The probe mix also contains a control probe for the 8 centromere (D8Z2) labeled in blue. Aquarius® Microdeletion
Probe Specification
TRPS1, 8q23.3, Red EXT1, 8q24.11-q24.12, Green D8Z2, 8p11.1-q11.1, Blue
D8Z2 Langer-Giedion Chromosome 8
EXT1
TRPS1
D8S1009 D8S1020
D8S565 D8S98 D8S547 115Kb
131Kb
D8S527 D8S43
165Kb
206Kb
100Kb
Cat. No. LPU 020-SA (50μl) Cat. No. LPU 020-A (100μl)
Monosomy 1p36 Region The SKI probe is 115Kb, labeled in red, and covers a region including most of the SKI gene, the telomeric end of the MORN1 gene and the D1S2515 marker. The probe mix also contains a control probe for 1qter (Clone 160H23) labeled in green. Probe Specification
SKI, 1p36.33, Red 1qter, 1q44, Green
1p36
1qter Chromosome 1
GABRD
SKI
PRKCZ
D1S1328
D1S243
100Kb
D1S2515
115Kb
MORN1
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
67
15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:18 Page 68
Cat. No. LPU 017-SA (50μl) Cat. No. LPU 017-A (100μl)
Neurofibromatosis Type 1 Region The NF1 probe is 143Kb, labeled in red, and covers a region including the D17S2162 marker. The probe mix also contains a control probe for 17pter (Clone 202L17) labeled in green.
Aquarius® Microdeletion
Probe Specification
NF1, 17q11.2, Red 17pter, 17p13.3, Green
17pter NF1 Chromosome 17
NF1
RNF135 D17S1307
RAB11FIP4
D17S2162 D17S1972
D17S1681
143Kb 100Kb
Cat. No. LPU 005-SA (50μl) Cat. No. LPU 005-A (100μl)
Prader-Willi/Angelman (SNRPN) Region The Prader-Willi/Angelman (SNRPN) probe is 170Kb, labeled in red, and covers the whole SNRPN gene as well as entire imprinting center. The probe mix also contains a control probe for 15qter (Clone 154P1) labeled in green. Probe Specification
SNRPN
SNRPN, 15q11-13, Red 15qter, 15q26.3, Green 15qter Chromosome 15
Imprinting Centre
SNRPN PAR5
D15S63
UBE3A PAR1 D15S10
These products are available as analyte specific reagents. 170Kb
Analytical and performance characteristics are not established. 100Kb
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Cat. No. LPU 023-SA (50μl) Cat. No. LPU 023-A (100μl)
Rubinstein-Taybi Region The CREBBP probe, labeled in red, consists of two non-overlapping clones, 146Kb and 153Kb. The probes cover the entire CREBBP gene and flanking DNA, including the D16S3382 marker. The probe mix also contains a control probe for the 16 centromere (D16Z2) labeled in green. Probe Specification
Aquarius® Microdeletion
CREBBP, 16p13.3, Red D16Z2, 16p11.1-q11.1, Green
Rubinstein-Taybi D16Z2 Chromosome 16
DNASE1 TRAP1 D16S3382
CREBBP
D16S2906
146Kb
D16S3386
153Kb 100Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
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Cat. No. LPU 024-SA (50μl) Cat. No. LPU 024-A (100μl)
Saethre-Chotzen Region/ Williams-Beuren Region
Aquarius® Microdeletion
The TWIST1 probe is 179Kb, labeled in red, and covers a region including the entire TWIST1 gene and flanking DNA. The Williams-Beuren region probe, labeled in green, consists of three non-overlapping clones (148Kb, 144Kb and 204Kb), which cover much of the deletion region. Probe Specification
TWIST1, 7p21.1, Red WBSCR, 7q11.23, Green
TWIST1 FERD3L
HDAC9
D7S1459 D7S2495 D7S1683 D7S1400 100Kb
179Kb
Williams-Beuren Chromosome 7
Saethre-Chotzen
FZD9
WBSCR28 TBL2 WBSCR22 CLDN4
WBSCR9
D7S2476
148Kb
WBSCR27
ELN
WBSCR1
LIMK1
CYLN2
GTF2IRD1
GTF2I NCF1
RFC2
D7S613
144Kb
204Kb
100Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
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Cat. No. LPU 025-SA (50μl) Cat. No. LPU 025-A (100μl)
SHOX The SHOX probe is 164Kb, labeled in red, and covers a region including the entire SHOX gene and flanking DNA on chromosomes Y and X. The probe mix also contains control probes for the X centromere (DXZ1) labeled in blue, and for chromosome Y (DYZ1, the heterochromatic block at Yq12) labeled in green. Probe Specification
SHOX DYZ1
SHOX
Aquarius® Microdeletion
SHOX, Xp22.33/Yp11.2, Red DYZ1, Yq12, Green DXZ1, Xp11.1-q11.1, Blue
DXZ1
Chromosome Y Chromosome X
SHOX DXYS153
DYS290 DXYS86 DXYS28 164Kb
DXYS15
100Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
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Cat. No. LPU 007-SA (50μl) Cat. No. LPU 007-A (100μl)
Smith-Magenis (FLII) Region/Miller-Dieker Region
Aquarius® Microdeletion
The Miller-Dieker (LIS1) probe is 117Kb, labeled in red, and covers the entire LIS1 gene. The Smith-Magenis (FLII) mix, labeled in green, consists of two probes, 37Kb and 38Kb. The probes cover the entire FLII gene and flanking regions including the D17S447 marker. Probe Specification
LIS1, 17p13.3, Red FLII, 17p11.2, Green
Miller-Dieker Smith-Magenis Chromosome 17
Common Deletion Region
LIS1 CLU1
FLII
RAI1
D17S2027 D17S1566 D17S379 D17S2111
SMCR7
D17S2021
TOP3A D17S447 D17S1715
117Kb
37Kb 38Kb 100Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
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Cat. No. LPU 019-SA (50μl) Cat. No. LPU 019-A (100μl)
Smith-Magenis (RAI1) Region/Miller-Dieker Region The Miller-Dieker (LIS1) probe is 117Kb, labeled in red, and covers the entire LIS1 gene. The Smith-Magenis (RAI1) probe is 158Kb, labeled in green, and covers the centromeric end of the RAI1 gene and includes the D17S258 marker. Aquarius® Microdeletion
Probe Specification
LIS1, 17p13.3, Red RAI1, 17p11.2, Green
Miller-Dieker Smith-Magenis Chromosome 17
LIS1
RAI1
CLU1
DRG2
FLII SMCR7
D17S620
AF021115/ D17S2021 AF021118 D17S258
D17S379 D17S2027 D17S1566 D17S2111
117Kb
158Kb 100Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
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Cat. No. LPU 026-SA (50μl) Cat. No. LPU 026-A (100μl)
SRY The SRY probe, labeled in red, consists of two non-overlapping probes, 30Kb and 50Kb. The probes cover the entire SRY gene and flanking DNA, including the RPS4Y1 gene. The probe mix also contains control probes for the X centromere (DXZ1) labeled in blue and for chromosome Y (DYZ1, the heterochromatic block at Yq12) labeled in green.
Aquarius® Microdeletion
Probe Specification
SRY, Yp11.2, Red DYZ1, Yq12, Green DXZ1, Xp11.1-q11.1, Blue
SRY DYZ1
DXZ1
Chromosome Y Chromosome X
SRY
CD99
PAR
RPS4Y1
RH38681 DYS242 DYS376 30Kb
ZFY
DYS234
50Kb
100Kb
Cat. No. LPU 011-SA (50μl) Cat. No. LPU 011-A (100μl)
Williams-Beuren Region The Williams-Beuren probe, labeled in red, consists of three non-overlapping clones (148Kb, 144Kb and 204Kb), which cover much of the deletion region. The probe mix also contains a control probe for the 7 centromere (D7Z1) labeled in green. Probe Specification
Williams-Beuren, 7q11.23, Red D7Z1, 7p11.1-q11.1, Green
D7Z1 Williams-Beuren Chromosome 7
FZD9
WBSCR28 TBL2 WBSCR22 CLDN4
WBSCR9
D7S2476
148Kb
WBSCR27
ELN
WBSCR1
LIMK1
GTF2IRD1
GTF2I NCF1
D7S613
144Kb 100Kb
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CYLN2
RFC2
204Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
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Cat. No. LPU 009-SA (50μl) Cat. No. LPU 009-A (100μl)
Wolf-Hirschhorn Region The Wolf-Hirschhorn probe is 223Kb, labeled in red, and covers a region centromeric to the FGFR3 and LETM1 genes, including the D4S166 marker. The probe mix also contains a control probe for 4qter (Clone CTC-963K6) labeled in green. Probe Specification
Wolf-Hirschhorn, 4p16.3, Red 4qter, 4q35.2, Green Aquarius® Microdeletion
4qter
Wolf-Hirschhorn
Chromosome 4
FGFR3 D4S168
WHSC2
LETM1 WHSC1
D4S166
D4S43
223Kb 100Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
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Cat. No. LPU 018-SA (50μl) Cat. No. LPU 018-A (100μl)
XIST The XIST probe is 189Kb, labeled in red, and covers the entire XIST gene and flanking regions, including the DXS8235 and DXS7717 markers. The probe mix also contains a control probe for the X centromere (DXZ1) labeled in green. XIST, Xq13.2, Red DXZ1, Xp11.1-q11.1, Green
Aquarius® Microdeletion
Probe Specification
DXZ1 XIST X Chromosome
CHIC1
XISTFXYD8 DXS8235 DXS9758 DXS8079 DXS7717 189Kb 100Kb
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
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Subtelomere Subtelomere
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Subtelomere Specific Probes Cytocell’s subtelomere specific probes are located in the most distal region of chromosome specific DNA on each chromosome. Beyond this unique sequence material is the 100 to 300Kb region of telomere associated repeat followed by the cap of between 3 to 20Kb of tandemly repeated (TTAGGG)n sequence.
Subtelomere
The original second-generation set of probes is derived from PAC clones and was established in conjunction with the Institute of Molecular Medicine, part of Oxford University, in the UK. Continuing product improvements have led to some substitutions with alternative cosmid (35–40Kb) or BAC (150Kb) clones to give improved signal strength or chromosome specificity. The average probe size is therefore 100Kb, and all have been mapped to within a maximum of 600Kb of the true telomere.
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Subtelomere Specific Probes Cytocell offers a complete set of Subtelomere Specific Probes available in the Aquarius® liquid format. The set identifies 41 of the 46 human subtelomeres with the exclusion of the p-arm telomeres of the acrocentric chromosomes. The probes are available independently and directly labeled in either a red or a green fluorophore (Texas Red® or FITC spectra respectively). The probes are supplied concentrated and packaged in an economical 15μl format.
p-arm Subtelomere Specific Probes
q-arm Subtelomere Specific Probes
LPT 01PR/G-A
1q
LPT 01QR/G-A
2p
LPT 02PR/G-A
2q
LPT 02QR/G-A
3p
LPT 03PR/G-A
2q NP LPT 02QNPR/G-A
4p
LPT 04PR/G-A
3q
LPT 03QR/G-A
5p
LPT 05PR/G-A
4q
LPT 04QR/G-A
6p
LPT 06PR/G-A
5q
LPT 05QR/G-A
7p
LPT 07PR/G-A
6q
LPT 06QR/G-A
8p
LPT 08PR/G-A
7q
LPT 07QR/G-A
9p
LPT 09PR/G-A
8q
LPT 08QR/G-A
10p LPT 10PR/G-A
9q
LPT 09QR/G-A
11p LPT 11PR/G-A
10q
LPT 10QR/G-A
12p LPT 12PR/G-A
11q
LPT 11QR/G-A
16p LPT 16PR/G-A
12q
LPT 12QR/G-A
17p LPT 17PR/G-A
13q
LPT 13QR/G-A
18p LPT 18PR/G-A
14q
LPT 14QR/G-A
19p LPT 19PR/G-A
15q
LPT 15QR/G-A
20p LPT 20PR/G-A
16q
LPT 16QR/G-A
XpYp LPT XYPR/G-A
17q
LPT 17QR/G-A
18q
LPT 18QR/G-A
19q
LPT 19QR/G-A
20q
LPT 20QR/G-A
21q
LPT 21QR/G-A
22q
LPT 22QR/G-A
Subtelomere
1p
XqYq LPT XYQR/G-A
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
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Subtelomere
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Paints
Paints
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Whole Chromosome Painting Probes Cytocell offers a comprehensive range of Whole Chromosome Painting probes available in the Aquarius® liquid format. The probes are available in either a red or a green fluorophore (Texas Red® or FITC spectra respectively). They are ready to use. The probes are supplied in an economical 50μl format.
Paints
Green Whole Chromosome Paints
Red Whole Chromosome Paints
Cat. No. LPP 01G-A
Cat. No. LPP 01R-A
Cat. No. LPP 02G-A
Cat. No. LPP 02R-A
Cat. No. LPP 03G-A
Cat. No. LPP 03R-A
Cat. No. LPP 04G-A
Cat. No. LPP 04R-A
Cat. No. LPP 05G-A
Cat. No. LPP 05R-A
Cat. No. LPP 06G-A
Cat. No. LPP 06R-A
Cat. No. LPP 07G-A
Cat. No. LPP 07R-A
Cat. No. LPP 08G-A
Cat. No. LPP 08R-A
Cat. No. LPP 09G-A
Cat. No. LPP 09R-A
Cat. No. LPP 10G-A
Cat. No. LPP 10R-A
Cat. No. LPP 11G-A
Cat. No. LPP 11R-A
Cat. No. LPP 12G-A
Cat. No. LPP 12R-A
Cat. No. LPP 13G-A
Cat. No. LPP 13R-A
Cat. No. LPP 14G-A
Cat. No. LPP 14R-A
Cat. No. LPP 15G-A
Cat. No. LPP 15R-A
Cat. No. LPP 16G-A
Cat. No. LPP 16R-A
Cat. No. LPP 17G-A
Cat. No. LPP 17R-A
Cat. No. LPP 18G-A
Cat. No. LPP 18R-A
Cat. No. LPP 19G-A
Cat. No. LPP 19R-A
Cat. No. LPP 20G-A
Cat. No. LPP 20R-A
Cat. No. LPP 21G-A
Cat. No. LPP 21R-A
Cat. No. LPP 22G-A
Cat. No. LPP 22R-A
Cat. No. LPP 0XG-A
Cat. No. LPP 0XR-A
Cat. No. LPP 0YG-A
Cat. No. LPP 0YR-A
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
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Satellites
Satellites
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Satellite Enumeration Probes Cytocell’s Enumeration Satellite probes are chromosome specific sequences generated from highly repeated human satellite DNA located in the centromeric, pericentromeric or heterochromatic regions of each chromosome. Cytocell offers a complete range of satellite probes available in the Aquarius® liquid format. The probes are available independently and directly labeled in either red or green fluorophore (Texas Red® or FITC spectra respectively). The probes are supplied concentrated and packaged in an economical 15μl format.
Satellites
Green Satellite Enumeration Probes
84
Red Satellite Enumeration Probes
Cat. No. LPE 001G-A
Cat. No. LPE 001R-A
Cat. No. LPE 002G-A
Cat. No. LPE 002R-A
Cat. No. LPE 003G-A
Cat. No. LPE 003R-A
Cat. No. LPE 004G-A
Cat. No. LPE 004R-A
Cat. No. LPE 005G-A (Chromosome 1,5,19)
Cat. No. LPE 005R-A (Chromosome 1,5,19)
Cat. No. LPE 006G-A
Cat. No. LPE 006R-A
Cat. No. LPE 007G-A
Cat. No. LPE 007R-A
Cat. No. LPE 008G-A
Cat. No. LPE 008R-A
Cat. No. LPE 009G-A
Cat. No. LPE 009R-A
Cat. No. LPE 010G-A
Cat. No. LPE 010R-A
Cat. No. LPE 011G-A
Cat. No. LPE 011R-A
Cat. No. LPE 012G-A
Cat. No. LPE 012R-A
Cat. No. LPE 013G-A (Chromosome 13,21)
Cat. No. LPE 013R-A (Chromosome 13,21)
Cat. No. LPE 014G-A (Chromosome 14,22)
Cat. No. LPE 014R-A (Chromosome 14,22)
Cat. No. LPE 015G-A
Cat. No. LPE 015R-A
Cat. No. LPE 016G-A
Cat. No. LPE 016R-A
Cat. No. LPE 017G-A
Cat. No. LPE 017R-A
Cat. No. LPE 018G-A
Cat. No. LPE 018R-A
Cat. No. LPE 020G-A
Cat. No. LPE 020R-A
Cat. No. LPE 0XG-A
Cat. No. LPE 0XR-A
Cat. No. LPE 0YcG-A
Cat. No. LPE 0YcR-A
Cat. No. LPE 0YqG-A
Cat. No. LPE 0YqR-A
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Cat. No. LPE 008B-A (30μl)
Cat. No. LPE 017B-A (30μl)
Cat. No. LPE 012B-A (30μl)
Blue Labeled Satellite Enumeration Probes Cytocell offers a limited range of satellite probes directly labeled in a blue fluorophore. The probes are supplied concentrated and packaged in an economical 30µl format. • • • •
Chromosome 8 Chromosome 12 Chromosome 17 Other chromosomes are available upon request
Cat. No. LPE 0XYc-A (100μl) Cat. No. LPE 0XYq-A (100μl)
Dual Labeled Satellite Probe Sets We also offer two dual labeled X&Y probe sets available in the Aquarius® liquid range in a 100μl format. XYc: Xp11.1-q11.1 directly labeled with a green fluorophore and Yp11.1-q11.1 with a red fluorophore. XYq: Xp11.1-q11.1 directly labeled with a green fluorophore and Yq12 with a red fluorophore. Satellites
Cat. No. LPE NOR-A (100μl)
Acro-P-Arm Probe The Nucleolar Organizer Regions (NOR) contain clusters of genes, which code for the three largest structural rRNA molecules (5.8S, 18S and 28S). Cytocell's Acro-P-Arm Probe is specific for rRNA genes located in the short arms of the acrocentric chromosomes (13, 14, 15, 21 and 22), labeled in red.
These products are available as analyte specific reagents. Analytical and performance characteristics are not established.
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Accessories
Accessories
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Accessories Cat. No.
Description
PCA005
Rubber Solution Glue 15g
PCN003
Vectashield 10ml
PCN004
Hybridization Chamber
DES500L
0.125μg/ml DAPI 500μl/vial
DES1000L
0.125μg/ml DAPI 1000μl/vial
DFS500L
1.0μg/ml DAPI 500μl/vial
DSS500L
0.0625μg/ml DAPI 500μl/vial
HA500L
Hybridization Solution A 500μl/vial
HB500L
Hybridization Solution B 500μl/vial
HA1000L
Hybridization Solution A 1000μl/vial
HB1000L
Hybridization Solution B 1000μl/vial
PCA003
20x SSC (100ml)
ADR123
Detection reagent for indirectly labeled probes (6 month expiry, 2-3 week lead time, min order quantity 10 units) Cytocell Slide Surface Thermometer (pack 4)
Accessories
PCN002
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Ordering information
Ordering Information
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Ordering Information Aquarius® Hematology Probe Range Summary Probe Name
Chromosome Region
Probe Type
Control Probe
Volume (μl)
13q14.3
13q14.3
Deletion
13qter
50 or 100
LPH 006-A
Alpha satellite 12 red
12p11.1-q11.1
Enumeration
N/A
50 or 100
LPH 028-A
AML1
21q22.12
Breakapart
N/A
50 or 100
LPH 027-A
AML1/ETO Dual Fusion
21q22.12/8q21.3
Translocation
N/A
50 or 100
LPH 026-A
ATM
11q22.3
Deletion
D11Z1
50 or 100
LPH 011-A
BCL6
3q27.3
Breakapart
N/A
50 or 100
LPH 035-A
BCR/ABL Dual Fusion
22q11/9q34
Translocation
N/A
50 or 100
LPH 007-A
BCR/ABL Plus Dual Fusion
22q11/9q34
Translocation/Deletion
N/A
50 or 100
LPH 038-A
CBFβ/MYH11 Dual Fusion
16q22/16p13
Translocation
N/A
50 or 100
LPH 022-A
CKS1B/CDKN2C (P18)
1q21/1p32.3
Amplification/Deletion
N/A
50 or 100
LPH 039-A
cMYC
8q24.21
Breakapart
N/A
50 or 100
LPH 010-A
D13S319
13q14.2
Deletion
13qter
50 or 100
LPH 042-A
D13S25
13q14.3
Deletion
13qter
50 or 100
LPH 043-A
Del (5q)
5q31.2
Deletion
5p15.31
50 or 100
LPH 024-A
Del (7q)
7q22/7q31
Deletion
N/A
50 or 100
LPH 025-A
Del (20q)
20q12/20q13.12
Deletion
N/A
50 or 100
LPH 020-A
E2A
19p13
Breakapart
N/A
50 or 100
LPH 019-A
EVI1
3q26.2
Breakapart
N/A
50 or 100
LPH 036-A
FIP1L1/CHIC2/PDGFRA
4q12
Deletion/Fusion
N/A
50 or 100
LPH 032-A
IGH
14q32.3
Breakapart
N/A
50 or 100
LPH 014-A
IGH/BCL2 Dual Fusion
14q32.3/18q21
Translocation
N/A
50 or 100
LPH 018-A
IGH/CCND1 (BCL1) Dual Fusion
14q32.3/11q13
Translocation
N/A
50 or 100
LPH 021-A
IGH/CCND3 Dual Fusion
14q32.3/6p21
Translocation
N/A
50 or 100
LPH 040-A
IGH/cMYC Dual Fusion
14q32.3/8q24.21
Translocation
N/A
50 or 100
LPH 041-A
IGH/FGFR3 Dual Fusion
14q32.3/4p16.3
Translocation
N/A
50 or 100
LPH 030-A
IGH/MAF Dual Fusion
14q32.3/16q23
Translocation
N/A
50 or 100
LPH 029-A
IGH/MAFB Dual Fusion
14q32.3/20q12
Translocation
N/A
50 or 100
LPH 044-A
IGH/MYEOV Dual Fusion
14q32.3/11q13
Translocation
N/A
50 or 100
LPH 045-A
IGK
2p11.2
Breakapart
N/A
50 or 100
LPH 034-A
IGL
22q11.2
Breakapart
N/A
50 or 100
LPH 033-A
MLL
11q23
Breakapart
N/A
50 or 100
LPH 013-A
MYB
6q23
Deletion
D6Z1
50 or 100
LPH 016-A
P16
9p21
Deletion
D9Z3
50 or 100
LPH 009-A
P53
17p13
Deletion
D17Z1
50 or 100
LPH 017-A LPH 052-A
P53/ATM Combination
17p13/11q22.3
Deletion
N/A
50 or 100
PDGFRB
5q32
Breakapart
N/A
50 or 100
LPH 031-A
PML/RARα Dual Fusion
15q24.1/17q21
Translocation
N/A
50 or 100
LPH 023-A
TCL1
14q32.13
Breakapart
N/A
50 or 100
LPH 046-A
TCRAD
14q11.2
Breakapart
N/A
50 or 100
LPH 047-A
TCRB
7q34
Breakapart
N/A
50 or 100
LPH 048-A
TEL/AML1 Dual Fusion
12p13.2/21q22.12
Translocation
N/A
50 or 100
LPH 012-A
TLX1
10q24
Breakapart
N/A
50 or 100
LPH 049-A
TLX3
5q35
Breakapart
N/A
50 or 100
LPH 050-A
* for 50µl volume probes add -SA to catalog number, e.g: LPH ### -SA
Ordering Information
Cat. No.*
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Ordering Information Aquarius® Hematology Panel LPH CLL-A or LPH CLL-SA Product Description
Chromosome Region
Probe Type
Control Probe
Volume (μl)
P53
17p13
Deletion
D17Z1
50 or 100
ATM
11q22.3
Deletion
D11Z1
50 or 100
MYB
6q23
Deletion
D6Z1
50 or 100
13q14.3
13q14.3
Deletion
13qter
50 or 100
Chromosome 12 Enumeration Probe
12p11.1-q11.1
Enumeration
N/A
50 or 100
Aquarius® Tissue Pretreatment Kit Summary Product Desription
Cat. No.
Aquarius® Tissue Pretreatment Kit* Reagent 1 (1x1L), Reagent 2 (1x10mL)
LPS 100
*This product is provided under an agreement between Life Technologies Corporation and Cytocell Ltd and is available for human diagnostic or life science use only.
Aquarius® Pathology Probe Range Summary Probe Name
Chromosome Region
Probe Type
Control Probe
Volume (μl)
Cat. No.*
ALK
2p23
Breakapart
N/A
50 or 100
LPS 019-A
CHOP
12q13
Breakapart
N/A
50 or 100
LPS 015-A
C-MET
7q31
Amplification
D7Z1
50 or 100
LPS 004-A
EGFR
7p11.2
Amplification
D7Z1
50 or 100
LPS 003-A
ERG
21q22.2
Control
N/A
25 or 50
LPS 099-A
EML4
2p21
Breakapart
N/A
50 or 100
LPS 020-A
EWSR1
22q12
Breakapart
N/A
50 or 100
LPS 006-A
EWSR1/ERG Dual Fusion
22q12/21q22
Translocation
N/A
50 or 100
LPS 008-A
FGFR1
8p12
Breakapart/Amplification
D8Z2
50 or 100
LPS 018-A
FLI1/EWSR1 Dual Fusion
11q24/22q12
Translocation
N/A
50 or 100
LPS 007-A
HER2
17q12
Amplification
N/A
50 or 100
LPS 001-A
MALT1
18q21
Breakapart
N/A
50 or 100
LPS 017-A
MDM2
12q15
Amplification
D12Z1
50 or 100
LPS 016-A
N-MYC
2p24.3
Amplification
LAF (2q11)
50 or 100
LPS 009-A
PAX3
2q35
Breakapart
N/A
50 or 100
LPS 012-A LPS 013-A
PAX7
1p36
Breakapart
N/A
50 or 100
RB1
13q14.2
Deletion
13qter
50 or 100
LPS 011-A
SRD (CHD5)
1p36
Deletion
1qter
50 or 100
LPS 010-A
SYT
18q11.2
Breakapart
N/A
50 or 100
LPS 014-A
TMPRSS2
21q22.3
Breakapart
N/A
25 or 50
LPS 098-A
TOP2A
17q21
Amplification/Deletion
D17Z1
50 or 100
LPS 002-A
ZNF217
20q13
Amplification
20pter
50 or 100
LPS 005-A
* for 50µl volume probes add -SA to catalog number, e.g: LPS ### -SA
Ordering Information
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15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:19 Page 92
Ordering Information Aquarius® Microdeletion Probe Range Summary Probe Name Chromosome Region Alagille (JAG1) Region 20p12.2 Angelman (UBE3A/D15S10) Region 15q11-13 CHARGE Region 8q12.1-8q12.2
Probe Locus Identification Control Locus JAG1 20qter UBE3A/D15S10 15qter CHD7 D8Z2
Cat. No.* LPU 012-A LPU 006-A LPU 021-A
Cri-Du-Chat Region/SOTOS Region 5p15.31/5p15.2/5q35 DiGeorge II (10p14) 10p14
FLJ25076, CTNND2, NSD1 N/A CUGBP2 D10Z1
50 or 100 50 or 100
LPU 013-A LPU 015-A
DiGeorge TBX1 Region & 22q13.3 Region
22q11.21/22q13.3
TBX1, N85A3
N/A
50 or 100
LPU 014-A
DiGeorge/VCFS N25 Region & 22q13.3 Region
22q11.21/22q13.3
N25/D22S75, N85A3
N/A
50 or 100
LPU 010-A
DiGeorge/VCFS TUPLE1 Region & 22q13.3 Region
22q11.21/22q13.3
TUPLE1, N85A3
N/A
50 or 100
LPU 004-A
Kallmann (KAL1) Region/STS Region Langer-Giedion Region Monosomy 1p36 Region Neurofibromatosis Type 1 Region Prader-Willi/Angelman (SNRPN) Region Rubinstein-Taybi Region
Xp22.31
KAL1, STS
DXZ1
50 or 100
LPU 016-A
8q23.3/8q24.11-q24.12 1p36.33 17q11.2 15q11-13
TRPS1, EXT1 1p36 NF1 SNRPN
D8Z2 1qter 17pter 15qter
50 50 50 50
LPU LPU LPU LPU
Saethre-Chotzen Region/ Williams-Beuren Region
or or or or
100 100 100 100
022-A 020-A 017-A 005-A
16p13.3
CREBBP
D16Z2
50 or 100
LPU 023-A
7p21.1/7q11.23
TWIST1, WBSCR
N/A
50 or 100
LPU 024-A
SHOX
Xp22.33/Yp11.32
SHOX
DXZ1, DYZ1
50 or 100
LPU 025-A
Smith-Magenis (RAI1) Region/Miller-Dieker Region
17p11.2/17p13.3
RAI1, LIS1
N/A
50 or 100
LPU 019-A
Smith-Magenis (FLII) Region/Miller-Dieker Region
17p11.2/17p13.3
FLII, LIS1
N/A
50 or 100
LPU 007-A
SRY
Yp11.31
SRY
DXZ1, DYZ1
50 or 100
LPU 026-A
Williams-Beuren Region
7q11.23
WBSCR
D7Z1
50 or 100
LPU 011-A
Wolf-Hirschhorn Region
4p16.3
WHSC1/2
4qter
50 or 100
LPU 009-A
XIST
Xq13.2
XIST
DXZ1
50 or 100
LPU 018-A
* for 50µl volume probes add -SA to catalog number, e.g: LPU ### -SA
Ordering Information
Volume (μl) 50 or 100 50 or 100 50 or 100
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15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:19 Page 93
Ordering Information Aquarius速 Subtelomere Specific Probe Range Summary Probe Specificity
Clone Name
Marker (STS)
1p
CEB108
CEB108/T7
-
LPT 01PR/G-A
1q
160H23
1qtel19
D1S3739
LPT 01QR/G-A
2p
dJ892G20
2ptel27
D2S2983
LPT 02PR/G-A
2q
dJ1011O17
1011017
-
LPT 02QR/G-A
2q NP
172I13
2qtel47
D2S2986
LPT 02QNPR/G-A
3p
dJ1186B18
3ptel25
D3S4559
LPT 03PR/G-A
3q
196F4
3qtel06
D3S1272
LPT 03QR/G-A
4p
36P21
4ptel04
D4S3360
LPT 04PR/G-A
4q
dJ963K6
4qtel11
-
LPT 04QR/G-A
5p
189N21
5ptel48
-
LPT 05PR/G-A
5q
240G13
5qtel70
D5S2907
LPT 05QR/G-A
6p
62I11
6ptel48
-
LPT 06PR/G-A
6q
57H24
6qtel54
D6S2522
LPT 06QR/G-A
7p
109a6
-
RH104000
LPT 07PR/G-A
7q
2000a5
-
RH48601
LPT 07QR/G-A
8p
dJ580L5
8ptel91
D8S2333
LPT 08PR/G-A
8q
489D14
8qtel11
D8S1925
LPT 08QR/G-A
9p
43N6
-
RH65569
LPT 09PR/G-A
9q
112N13
9qtel33
D9S2168
LPT 09QR/G-A
10p
306F7
10ptel45
D10S2488
LPT 10PR/G-A
10q
137E24
-
RH44494
LPT 10QR/G-A
11p
dJ908H22
11ptel03
D11S2071
LPT 11PR/G-A
11q
dJ770G7
11qtel38
D11S4974
LPT 11QR/G-A
12p
496A11
-
D12S200
LPT 12PR/G-A
12q
221K18
12qtel87
D12S2343
LPT 12QR/G-A
13q
163C9
13qtel56
D13S1825
LPT 13QR/G-A
14q
dJ820M16
-
D14S1420
LPT 14QR/G-A
15q
154P1
WI-5214
D15S936
LPT 15QR/G-A
16p
121I4
16ptel05
D16S3400
LPT 16PR/G-A
16q
240G10
-
RH80305
LPT 16QR/G-A
17p
2111b1
17ptel80
D17S2199
LPT 17PR/G-A
17q
362K4
17qtel13
D17S2200
LPT 17QR/G-A
18p
74G18
VIJ-YRM2102
D18S552
LPT 18PR/G-A
18q
dJ964M9
18qtel11
D18S1390
LPT 18QR/G-A
19p
dJ546C11
19ptel29
-
LPT 19PR/G-A
19q
F21283
-
RH102404
LPT 19QR/G-A
20p
dJ1061L1
20pthy33
D20S502
LPT 20PR/G-A
20q
81F12
20qtel14
-
LPT 20QR/G-A
21q
63H24
21qtel07
D21S1575
LPT 21QR/G-A
22q
99K24
22qtel31
D22S1726
LPT 22QR/G-A
XpYp**
839D20
-
DXYS129
LPT XYPR/G-A
XqYq***
225F6 C8.2/1
CDY16C07 SYBL1
Z43206 -
LPT XYQR/G-A
Cat. No.*
R specifies a red label, G specifies a green label This probe is specific for the p-arms of both X and Y This probe is specific for the q-arms of both X and Y Non Polymorphic
Ordering Information
* ** *** NP
Accession Number (if available)
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15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:19 Page 94
Ordering Information Aquarius® Whole Chromosome Painting Probe Range Summary Chromosome
Volume (μl)
Cat. No.*
1
50
LPP 01R/G-A
2
50
LPP 02R/G-A
3
50
LPP 03R/G-A
4
50
LPP 04R/G-A
5
50
LPP 05R/G-A
6
50
LPP 06R/G-A
7
50
LPP 07R/G-A
8
50
LPP 08R/G-A
9
50
LPP 09R/G-A
10
50
LPP 10R/G-A
11
50
LPP 11R/G-A
12
50
LPP 12R/G-A
13
50
LPP 13R/G-A
14
50
LPP 14R/G-A
15
50
LPP 15R/G-A
16
50
LPP 16R/G-A
17
50
LPP 17R/G-A
18
50
LPP 18R/G-A
19
50
LPP 19R/G-A
20
50
LPP 20R/G-A
21
50
LPP 21R/G-A
22
50
LPP 22R/G-A
X
50
LPP 0XR/G-A
Y
50
LPP 0YR/G-A
* R specifies a red label, G specifies a green label
Whole Chromosome Paint Combinations Chromosome
Description
Volume (μl)
Cat. No.*
1/2/4
Whole chromosome paint combination 1,2,4 (3 color, 3 probe combination) directly labeled
100
LPP 124-A
1/2/4 and 3/5/6
Whole chromosome paint combination 1,2,4 and 3,5,6 (2 color, 6 probe combination) indirectly labeled
100
LPP 356-A
Ordering Information
* Minimum order of ten units (1000μl volume). Orders are subject to 4-6 weeks lead time
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Ordering Information Aquarius® Satellite Enumeration Probe Range Summary Chromosome
Locus
Chromosome Region
DNA Class
Volume (μl)
1
D1Z1
1q12
satellite III
15
Cat. No.* LPE 001R/G-A
2
D2Z2
2p11.1-q11.1
α-satellite
15
LPE 002R/G-A
3
D3Z1
3p11.1-q11.1
α-satellite
15
LPE 003R/G-A
4
D4Z1
4p11.1-q11.1
α-satellite
15
LPE 004R/G-A
1/5/19
D1Z7
1p11.1-q11.1
α-satellite
15
LPE 005R/G-A
D5Z2
5p11.1-q11.1 LPE 006R/G-A
D19Z3
19p11.1-q11.1
6
D6Z1
6p11.1-q11.1
α-satellite
15
7
D7Z1
7p11.1-q11.1
α-satellite
15
LPE 007R/G-A
8
D8Z2
8p11.1-q11.1
α-satellite
15
LPE 008R/G-A
D8Z2
8p11.1-q11.1
α-satellite
30
LPE 008B-A
9
D9Z3
9q12
satellite III
15
LPE 009R/G-A
10
D10Z1
10p11.1-q11.1
α-satellite
15
LPE 010R/G-A
11
D11Z1
11p11.1-q11.1
α-satellite
15
LPE 011R/G-A
12
D12Z3
12p11.1-q11.1
α-satellite
15
LPE 012R/G-A
D12Z3
12p11.1-q11.1
α-satellite
30
LPE 012B-A
13/21
D13Z1
13p11.1-q11.1
α-satellite
15
LPE 013R/G-A
D21Z1
21p11.1-q11.1
D14Z1
14p11.1-q11.1
α-satellite
15
LPE 014R/G-A
D22Z1
22p11.1-q11.1
15
D15Z4
15p11.1-q11.1
α-satellite
15
LPE 015R/G-A
16
D16Z2
16p11.1-q11.1
α-satellite
15
LPE 016R/G-A
17
D17Z1
17p11.1-q11.1
α-satellite
15
LPE 017R/G-A
D17Z1
17p11.1-q11.1
α-satellite
30
LPE 017B-A
18
D18Z1
18p11.1-q11.1
α-satellite
15
LPE 018R/G-A
20
D20Z1
20p11.1-q11.1
α-satellite
15
LPE 020R/G-A
X
DXZ1
Xp11.1-q11.1
α-satellite
15
LPE 0XR/G-A
Yc
DYZ3
Yp11.1-q11.1
α-satellite
15
LPE 0YcR/G-A
Yq
DYZ1
Yq12
satellite III
15
LPE 0YqR/G-A
XYc Dual Labeled
DXZ1
Xp11.1-q11.1
α-satellite
100
LPE 0XYc-A
DYZ3
Yp11.1-q11.1 100
LPE 0XYq-A
14/22
XYq Dual Labeled
DXZ1
Xp11.1-q11.1
α-satellite
DYZ1
Yq12
satellite III
* R specifies a red label, G specifies a green label and B specifies a blue label.
Acro-P-Arm Probe Chromosome
Color
Volume (μl)
Cat. No.
13, 14, 15, 21, 22
Red
100
LPE NOR-A
Ordering Information
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15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:20 Page 96
Ordering Information
Index by Chromosome Number Chromosome
Probe Name
1-22, X, Y 1-22, X, Y 1-22, X, Y 1 1 1 1 2 2 2 2 2 3 3 4 4 4, 14 5 5 5 5 6 6, 14 7 7 7 7 7 7 8, 21 8 8 8 8 8, 14 9 9, 22 9, 22 10 10 11 11, 17 11 11, 14 11, 22 11, 14 12, 21 12
Painting Probes-Aquarius速 Satellite Probes-Aquarius速 Subtelomere Specific Probes-Aquarius速 Monosomy 1p36 Region SRD (CHD5) Deletion PAX7 Breakapart CKS1B/CDKN2C (P18) Amplification/Deletion ALK Breakapart EML4 Breakapart IGK Breakapart PAX3 Breakapart N-MYC Amplificaton BCL6 Breakapart EVI1 Breakapart Wolf-Hirschhorn Region FIP1L1/CHIC2/PDGFRA Deletion/Fusion IGH/FGFR3 Translocation, Dual Fusion Del (5q) Deletion Cri-Du-Chat Region/SOTOS Region PDGFRB Breakapart TLX3 Breakapart MYB Deletion IGH/CCND3 Translocation, Dual Fusion Williams-Beuren Region Del (7q) Deletion Saethre-Chotzen Region/Williams-Beuren Region EGFR Amplification C-MET Amplification TCRB Breakapart AML1/ETO Translocation, Dual Fusion cMYC Breakapart CHARGE Region Langer-Giedion Region FGFR1 Breakapart/Amplification IGH/cMYC Translocation, Dual Fusion P16 Deletion BCR/ABL Translocation, Dual Fusion BCR/ABL Plus Translocation, Dual Fusion DiGeorge II (10p14) TLX1 Breakapart ATM Deletion P53/ATM Combination MLL Breakapart IGH/CCND1 (BCL1) Translocation, Dual Fusion FLI1/EWSR1 Translocation, Dual Fusion IGH/MYEOV Translocation, Dual Fusion TEL/AML1 Translocation, Dual Fusion CHOP Breakapart
96
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15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:20 Page 97
Chromosome
Probe Name
12 13 13 13 13 14 14, 18 14, 16 14, 20 14 14 15 15 15, 17 16 16 17 17 17 17 17 17 18 18 19 20 20 20 21 21, 22 21 21 22 22 22 22 22 X X X, Y Y Various Various
MDM2 Amplification 13q14.3 Deletion RB1 Deletion D13S319 Deletion D13S25 Deletion IGH Breakapart IGH/BCL2 Translocation, Dual Fusion IGH/MAF Translocation, Dual Fusion IGH/MAFB Translocation, Dual Fusion TCL1 Breakapart TCRAD Breakapart Angelman (UBE3A/D15S10) Region Prader-Willi/Angelman (SNRPN) Region PML/RARα Translocation, Dual Fusion CBFβ/MYH11 Translocation, Dual Fusion Rubinstein-Taybi Region Smith-Magenis (RAI1) Region/Miller-Dieker Region Smith-Magenis (FLII) Region/Miller-Dieker Region P53 Deletion Neurofibromatosis Type 1 Region HER2 Amplification TOP2A Amplification/Deletion MALT1 Breakapart SYT Breakapart E2A Breakapart Del (20q) Deletion Alagille (JAG1) Region ZNF217 Amplification AML1 Breakapart EWSR1/ERG Translocation, Dual Fusion ERG Control TMPRSS2 Breakapart DiGeorge/VCFS TUPLE1 Region & 22q13.3 Region DiGeorge/VCFS N25 Region & 22q13.3 Region DiGeorge TBX1 Region & 22q13.3 Region IGL Breakapart EWSR1 Breakapart Kallmann (KAL1) Region/STS Region XIST SHOX SRY Aquarius® Hematology Panel Acro-P-Arm Probe
Page 50 17 52 17 18 21 22 27 28 36 36 59 68 35 15 69 73 72 32 68 49 55 50 53 20 19 59 55 9 47 54 54 63 64 65 30 46 66 76 71 74 40 85
Ordering Information
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Ordering Information
Index by Probe Name Probe Name
Chromosome
13q14.3 Deletion Acro-P-Arm Probe Alagille (JAG1) Region ALK Breakapart AML1/ETO Translocation, Dual Fusion AML1 Breakapart Angelman (UBE3A/D15S10) Region Aquarius® Hematology Panel ATM Deletion BCL6 Breakapart BCR/ABL Plus Translocation, Dual Fusion BCR/ABL Translocation, Dual Fusion CBFβ/MYH11 Translocation, Dual Fusion CHARGE Region CHOP Breakapart CKS1B/CDKN2C (P18) Amplification/Deletion C-MET Amplification cMYC Breakapart Cri-Du-Chat Region/SOTOS Region D13S25 Deletion D13S319 Deletion Del (5q) Deletion Del (7q) Deletion Del (20q) Deletion DiGeorge II (10p14) DiGeorge TBX1 Region & 22q13.3 Region DiGeorge/VCFS N25 Region & 22q13.3 Region DiGeorge/VCFS TUPLE1 Region & 22q13.3 Region EGFR Amplification EVI1 Breakapart EML4 Breakapart ERG Control E2A Breakapart EWSR1 Breakapart EWSR1/ERG Translocation, Dual Fusion FGFR1 Breakapart/Amplification FIP1L1/CHIC2/PDGFRA Deletion/Fusion FLI1/EWSR1 Translocation, Dual Fusion HER2 Amplification IGH Breakapart IGH/BCL2 Translocation, Dual Fusion IGH/CCND1 (BCL1) Translocation, Dual Fusion IGH/CCND3 Translocation, Dual Fusion IGH/cMYC Translocation, Dual Fusion IGH/FGFR3 Translocation, Dual Fusion
13q14.3 13,14,15,21,22 20p12.2 2p23 21q22.12/8q21.3 21q22.12 15q11-13 Various 11q22.3 3q27.3 22q11/9q34 22q11/9q34 16q22/16p13 8q12.1-8q12.2 12q13 1q21/1p32.3 7q31 8q24.21 5p15.31/5p15.2/5q35 13q14.3 13q14.2 5q31.2 7q22/7q31 20q12/20q13.12 10p14
17 85 59 44 10 9 59 40 11 14 13 12 15 60 44 16 45 16 61 18 17 18 19 19 62
22q11.21/22q13.3 22q11.21/22q13.3 22q11.21/22q13.3 7p11.2 3q26.2 2p21 21q22.2 19p13 22q12 22q12/21q22 8p12 4q12 11q24/22q12 17q12 14q32.3 14q32.3/18q21 14q32.3/11q13 14q32.3/6p21 14q32.3/8q24.21 14q32.3.3/4p16.3
65 64 63 45 20 46 54 20 46 47 49 21 48 49 21 22 23 24 25 26
98
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Probe Name
Chromosome
IGH/MAF Translocation, Dual Fusion IGH/MAFB Translocation, Dual Fusion IGH/MYEOV Translocation, Dual Fusion IGK Breakapart IGL Breakapart Kallmann (KAL1) Region /STS Region Langer-Giedion Region MALT1 Breakapart MDM2 Amplification MLL Breakapart Monosomy 1p36 Region MYB Deletion Neurofibromatosis Type 1 Region N-MYC Amplificaton P16 Deletion P53 Deletion P53/ATM Combination Painting Probes-Aquarius速 PAX3 Breakapart PAX7 Breakapart PDGFRB Breakapart PML/RAR留 Translocation, Dual Fusion Prader-Willi/Angelman (SNRPN) Region RB1 Deletion Rubinstein-Taybi Satellite Probes-Aquarius速 Saethre-Chotzen Region/Williams-Beuren Region SHOX Smith-Magenis (FLII) Region/Miller-Dieker Region Smith-Magenis (RAI1) Region/Miller-Dieker Region SRD (CHD5) Deletion SRY Subtelomere Specific Probes-Aquarius速 SYT Breakapart TCL1 Breakapart TCRAD Breakapart TCRB Breakapart TEL/AML1 Translocation, Dual Fusion TMPRSS2 Breakapart TLX1 Breakapart TLX3 Breakapart TOP2A Amplification/Deletion Williams-Beuren Region Wolf-Hirschhorn Region XIST ZNF217 Amplification
14q32.3/16q23 14q32.2/20q12 14q32.3/11q13 2p11.2 22q11.2 Xp22.31 8q23.3/8q24.11-q24.12 18q21 12q15 11q23 1p36.33 6q23 17q11.2 2p24.3 9p21 17p13 17p13/11q22.3 1-22, X, Y 2q35 1p36 5q32 15q24.1/17q21 15q11-13 13q14.2 16p13.3 1-22, X, Y 7p21.1/7q11.23 Xp22.33/Yp11.32 17p11.2/17p13.3 17p11.2/17p13.3 1p36 Yp11.31 1-22, X, Y 18q11.2 14q32.13 14q11.2 7q34 12p13.2/21q22.12 21q22.3 10q24 5q35 17q21 7q11.23 4p16.3 Xq13.2 20q13
Page 27 28 29 30 30 66 67 50 50 31 67 31 68 51 32 32 33 82 51 52 34 35 68 52 69 84 70 71 72 73 53 74 79 53 36 36 37 38 54 39 39 55 74 75 76 55 Ordering Information
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Ordering Information
Notes
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15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:20 Page 101
NEW
15539 CYTOCELL USA catalogue - no cutter guide with covers_Layout 1 19/11/2012 10:20 Page 102
Cytocell Ltd 3-4 Technopark Newmarket Road Cambridge CB5 8PB UK T: +44 (0) 1223 294048 F: +44 (0) 1223 294986 E: probes@cytocell.com
www.cytocell.com
Rainbow Scientific Inc 83 Maple Avenue Windsor CT 06095 USA T: 860.298.8382 F: 860.298.8586 E: info@rainbowscientific.com
cytocell-us.com
www.rainbowscientific.com