Research Day 2021 by M Dentistry

RESEARCH DAY | 2021

CONTENTS

WELCOME

Welcome Letter................................................................................................................................... page 1

Welcome To Research Day 2021!

Keynote Speaker.................................................................................................................................. page 2

Thank you for joining us in celebrating the research conducted by students, postdoctoral trainees, staff and faculty members at the University of Michigan School of Dentistry. This year’s first-ever online version of Research Day is a new format, but the variety and depth of scientific inquiry showcased today is as impressive as ever. We applaud this significant contribution to the school’s mission of advancing health through education, service, research and discovery.

Program Schedule................................................................................................................................ page 2 2021 Judges.......................................................................................................................................... page 2 2021 Research Day Finalists............................................................................................................... page 3 Posters........................................................................................................................................... page 4 - 11 Bio Art........................................................................................................................................... page 12 - 23

Laurie K. McCauley

2021 Sponsors............................................................................................................................. page 24 - 25 2021 Advertisers.......................................................................................................................... page 26 - 28

Vesa Kaartinen

Dating to the early days after our school was founded in 1875, our faculty and students have long been recognized for important research that advanced dentistry and many other areas of healthcare and science. Research Day’s origin is circa 1960 when “table clinics” were introduced to allow students to demonstrate their projects. In the 1980s, the format was expanded to what was known as the Student Research Forum. In 1999, various research initiatives were merged into the Research Day we know today. It is vital that we encourage and promote the groundbreaking science that is so important to our mission of educating the dentists, hygienists and scientists of tomorrow. Research Day 2021 will host 88 posters that highlight research in the school’s four themes: Cancer Biology & Therapeutics; Clinical, Population & Educational Research; Craniofacial, Skeletal Biology & Disease; and Tissue Engineering & Regenerative Medicine. We are pleased that our keynote speaker this year is Dr. Arlyne Simon, a nationally recognized biomedical engineer, author and entrepreneur. A platform architect at Intel Corporation’s Health and Life Science Business Unit, she will address “Powering through Uncertainty.” Her presentation will be available to the public starting at 1 p.m. Today’s activities are the result of a school-wide effort that includes staff from the Office of Research and the many faculty, students and staff members who support this special event in the life of our school. We offer a special thanks to the companies who have partnered with us to sponsor this year’s Research Day. Go Blue Dental Research!

EXPANDING THE SCHOOL OF DENTISTRY’S STATE-OF-THE-ART FACILITIES dent.umich.edu/blue-renew

Laurie K. McCauley, DDS, MS, PhD Dean

Vesa Kaartinen, PhD Associate Dean for Research

Research Day 1

2021 RESEARCH DAY FINALISTS

KEYNOTE SPEAKER: Arlyne B. Simon, PhD Platform Architect, Intel & Founder, Timouns

“Powering through Uncertainty” Dr. Simon is a biomedical engineer, author and inventor who graduated from the University of Michigan Macromolecular Science and Engineering PhD program and was a School of Dentistry T32-TEAM Training Grant trainee. Her keynote seminar titled “Powering through Uncertainty” will encourage and inspire our students, faculty and staff as we strive to meet our mission of advancing health through education, service, research and discovery.

1:00 – 2:00 pm KEYNOTE SPEAKER: Arlyne B. Simon, PhD

2:00 – 5:00 pm

Platform Architect, Intel & Founder, Timouns

Open to UM faculty, staff & students

Research Day Poster Session

2 Research Day

Poster Number: 47

Presenter: Oluwatobi Dauda (D1) Mentor: Romesh P. Nalliah Title: Emergency Department visits due to Dental Problems in Michigan

Presenter: Lea Sarment (D4) Mentor: Suncica Travan Title: Sclerostin antibody stimulates periodontal regeneration in alveolar bone defect

Poster Number: 69

Poster Number: 54

Presenter: Evan Booth (D4) Mentor: Margherita Fontana Title: Variability in Caries Management Decision-Making In a Dental School Setting

Presenter: Afriti Chinoy (Undergrad) Mentor: Yuji MIshina Title: Evc2 Function In Mesenchymal (Neural Crest Cells Derived) Tissue Is Critical For Molar Morphology

Poster Number: 4

Basic Science & Translational Research: PhD/DDS-PhD/Post Doc

Poster Number: 37

Presenter: Jonathan Misch (D4) Mentor: Marita R. Inglehart / Darnell Kaigler Title: Periodontists and Stem Cell Based Bone Grafting: A National Survey

Presenter: Matthew Galli (MS) Mentor: Hom-Lay Wang Title: Maintenance regularity differentially impacts periodontitisrelated tooth loss according to staging and grading

Clinical, Population, and Educational Research: PhD/DDS-PhD/Post Doc

2021 JUDGES Ge, Chunxi Gonzalez, Carlos Hatch, Nan Hoelscher, Diane Hu, Jan Inglehart, Marita Jin, Qiming Johnson, Lynn Kaartinen, Vesa Kasabreh, Najla Kim-Berman, Hera Li, Peng Lombaert, Isabelle

Poster Number: 71

Poster Number: 42

2:15 – 4:30 pm

411 Short Talks Judging Finalists

Bak, Sun-Yung Bauer, Trish Botero, Tatiana Castilho, Rogerio Chan, Hsun-Liang Chiego, Daniel D’Silva, Nisha Danciu, Theodora Eagle, Iwonka Eber, Bob Fenno, Chris Franceschi, Renny Furgeson, Danielle

Basic Science & Translational Research: DDS/DH/MS/Undergrad

Presenter: Angelie Baker / Lisa Walker (DH4) Mentor: Darlene Jones Title: Interventions for children on the autism spectrum for dental visits: a cross-sectional study

PROGRAM SCHEDULE

“Powering through Uncertainty”

Clinical, Population, and Educational Research: DDS/DH/MS/Undergrad

Poster Number: 18 Marti, Kyriaki May, Kenneth Mendonca, Daniela Mishina, Yuji Oh, Won Ono, Noriaki Ono, Wanida Pobocik, Andrea Roca, Herman Saglik, Berna Sasaki, Hajime Siddanna, Geetha Sierraalta, Marianella

Simmer, James Squarize, Cristiane Stefanac, Steve Sweier, Domenica Tarrazzi, Daler Tenuta, Livia VanDuine, Stefanie Vergotine, Rodney Wang, Hom-Lay Ward, Brent Weivoda, Megan Zhang, Honghao

Poster Number: 59

Presenter: Noam Gannot (PhD) Mentor: Peng Li Title: A Neural Control Circuit for Coughing

Poster Number: 22

Presenter: Marsha-Kay Hutchinson (DDS/PhD) Mentor: Nisha D’Silva Title: Inhibition of EGFR-mediated Phosphorylation of TRIP13 Sensitizes Oral Cancer to Radiation

Poster Number: 49

Presenter: Rahasudha Kannan (PhD) Mentor: Laurie K. McCauley Title: Apoptotic Cell Engulfment Induces Changes in Macrophage Nuclear Morphology and Transcriptional Regulation Pathways

Poster Number: 56

Presenter: Cindy Pérez-Pacheco (Postdoc) Mentor: Nisha D’Silva Title: Nerve Parameters Associated with Clinical Outcome in Oral Cancer

Presenter: Hiroki Ueharu (Postdoc) Mentor: Yuji Mishina Title: Enhanced BMP signaling induced ectopic X chromosome inactivation via increasing Xist expression, resulting in ectopic cartilage formation in the head

Poster Number: 44

Poster Number: 88

Presenter: Ying-Chun Pan (PhD) Mentor: Hsun-Liang Chan Title: Improving Dental Ultrasound Workflow with a Deep-learning Segmentation Model

Presenter: Shawn Hallett (DDS/PhD) Mentor: Noriaki Ono Title: Contribution of PTHrP-expressing chondrocytes in the cranial base synchondrosis

Poster Number: 82

Presenter: Najla Al Turkestani (PhD) Mentor: Lucia Cevidanes/Hajime Sasaki Title: Clinical Decision Support Systems in Dentistry

Research Day 3

POSTERS

POSTERS 1

Confidence in Current and Future Dental Providers Treating Special Needs Patients Lubin, D., Clark, D., Britton, L. Presenter(s): Alexis Lubin, Christine Clark, Jamie Britton Faculty: Darlene Jones POM - Periodontics and Oral Medicine

Inter-examiner Ultrasound Calibration of Periodontal Phenotype parameters: A retrospective study Maldonado, A., Chan H-L., Kripfgans, O. Presenter: Andriana Maldonado Faculty: Hsun-Liang Chan Hygiene, Periodontics & Oral Medicine Funding: The study was supported in part by the 2019 Basic Radiological Sciences Innovative Research Award from the Department of Radiology, University of Michigan, as well as NIH awards 1R21DE029005-01A1 and 1R21DE027765-01A1.

Hormonal Changes During Puberty and its Effect on the Oral Health of Young Females: A Literature Review

Interventions for children on the autism spectrum for dental visits: a cross-sectional study

Presenter(s): Cheyenne Giles, Diana Mogg Faculty: Valerie Nieto Hygiene, Periodontics & Oral Medicine

Barriers to Accessing Dental Care in the Mexican American Population

Presenter(s): Christina Louzon, Brooke Maroudis Faculty: Stefanie VanDuine Hygiene, Periodontics & Oral Medicine

Relationship between plant-based diet and periodontal disease Halsey, C., Pascua, N., Duff, S., Palesh, B. Presenter(s): Carianne Halsey, Nina Pascua Faculty: Sheree Duff Hygiene, Periodontics & Oral Medicine

4 Research Day

Examining the Effects of Coconut Oil, Sesame Oil, and CPP-ACP chewing gum on the pH Levels of Saliva Presenter(s): Erika Elliott, Jordyn Chouinard, Megan Kluck Faculty: Valerie Nieto Hygiene, Periodontics & Oral Medicine

Efficacy and Patient Acceptance of the Bamboo Bristle Toothbrush

Presenter(s): Taylor Hamilton, Maddison Phelps, Chelsea Spangler Faculty: Stefanie VanDuine Hygiene, Periodontics & Oral Medicine

Students’ Knowledge on Stretches to Prevent Musculoskeletal Pain and Injury

The Awareness among Dental and Dental Hygiene Students of the Opioid-Related Crises in Dental Patients Smith, M., Sawabini, M. Presenter(s): Merysta Smith, Maysa Sawabini Faculty: Martha McComas Hygiene, Periodontics & Oral Medicine

Dental Hygienists’ Perception and Utilization of Motivational Interviewing as a Health Behavior Change Model to Improve Oral Health

Presenter: Ligia B. Schmitd Faculty: Nisha D`Silva POM - Periodontics and Oral Medicine Funding: NIH/NIDCR DE027551 grant (NJD) and University of Michigan CEW+ Riecker Graduate Student Research Fund (LBS)

The Science and Toxicity of Mercury in Dental Amalgam Restorations

Presenter: Marcell Costa de Medeiros Faculty: Nisha D’SIlva POM - Periodontics and Oral Medicine Funding: NIH/NIDCR DE027551 (NJD).

Presenter(s): Marla Govan, Aihab Agour Faculty: Kenichi Kuroda BMSP - Biologic and Materials Sciences & Prosthodontics

Presenter: Marsha-Kay Hutchinson Faculty: Nisha D’Silva POM - Periodontics and Oral Medicine Funding: This work was supported by NIH/NIDCR T32-DE007057, NIH/NIDCR DE027551 and NIH/NCI CA250214 (NJD) and NIH/ NIDCR DE00007057 (MNDH) grants

Nerve Parameters Associated with Clinical Outcome in Oral Cancer Pérez-Pacheco, C., Schmitd, L.B., Bellile, E., Wolf, G.T., D’Silva, N.J. Presenter: Cindy Pérez-Pacheco Faculty: Nisha D’Silva POM - Periodontics and Oral Medicine Funding: NIH/NIDCR DE027551

Inhibition of EGFR-mediated Phosphorylation of TRIP13 Sensitizes Oral Cancer to Radiation Hutchinson, M.N.D., Banerjee, R., Liu, M., Bellile, E., Schmitd, L., Singh, P., Martin, K., Nyati, M., Ward, B., Mierzwa, M., D’Silva, N.J.

Govan, M., Agour, A.

Suppression of DMBT1 promotes invasion in Oral Cancer Medeiros, M.C., Singh, P., Banerjee, R., Piao, S., Bellile, E., Liu, M., Schmitd, L.B., Danella, E., Wellik, D., Wolf, G., D’Silva, N.J.

Farran, Y., Shahid, M., Nieto, V. Presenter(s): Youssef Farran, Mubarra Shahid Faculty: Valerie Nieto Hygiene, Periodontics & Oral Medicine

Nerve-cancer interaction: mechanism and clinical relevance in oral cancer Schmitd, L.B., Pérez-Pacheco, C.; Bellile, E., Wolf, G.T., D’Silva, N.J.

Mattit, W., Reidy, K., Sanderlin, J.

Amireh, F., Kennedy, M.G., Saunders, J. Presenter(s): Mary Kennedy, Fatin Amireh, Jessica Saunders Faculty: Stefanie VanDuine Hygiene, Periodontics & Oral Medicine

Presenter: Erika Danella Faculty: Nisha D’Silva POM - Periodontics and Oral Medicine Funding: NIDCR-R35 DE027551 and NCI-R01 CA250214

Accuracy and Confidence Levels with ICDAS Caries Detection: A Pilot Study Presenter(s): Waled Mattit, Kathleen Reidy, Julia Sandlerin Faculty: Martha McComas Hygiene, Periodontics & Oral Medicine

Oral Squamous Cell Carcinoma Co-opts Non-cancerous Epithelium to Enhance Spread Danella, E.B., Singh, P., Banerjee, R., Costa de Medeiros, M., Piao, S., Bellile, E., Liu, M., Schmitd, L.B., Russo, N., Wolf, G., D’Silva, N.J.

The Athlete’s Oral Health and Contributing Factors: A Closer Look Hamilton, T., Phelps, M., Spangler, C.

Jervis, K., Mundus, R., Shackelford, A. Presenter(s): Kali Jervis, Rachel Mundus, Alexis Shackelford Faculty: Martha McComas Hygiene, Periodontics & Oral Medicine Funding: University of Michigan’s Division of Dental Hygiene

Presenter(s): Taylor Cacciamani, Mehar Fatima, Han Vo Faculty: Marita Inglehart Hygiene, Periodontics & Oral Medicine

Elliott, E., Chouinard, J., Kluck, M.

Hernandez-Duran, B., Castillo, L., VanDuine, S. Presenter(s): Berenice Hernandez-Duran, Lucero Castillo, Stefanie VanDuine Faculty: Stefanie VanDuine Hygiene, Periodontics & Oral Medicine

The Effects of Oral Health Conditions on Dietary Choices

College students’ knowledge about the effects of tobacco use on oral health: A survey Cacciamani, T., Fatima, M., Vo, H.

Louzon, C., Maroudis, B.

Walker, L., Baker, A. Presenter(s): Angelie Baker, Lisa Walker Faculty: Darlene Jones Hygiene, Periodontics & Oral Medicine

Giles, C., Mogg, D., Nieto, V.

Chapa, A., Erickson, A., VanDuine, S., Eagle, I. Presenter(s): Angelica Chapa, Allyson Erickson Faculty: Iwonka Eagle Hygiene, Periodontics & Oral Medicine

Hand Heat-Map Representation of Data: Self-Reported Musculoskeletal Pain and the Use of Hand and Power- Scaling Instruments in Practicing Dental Hygienists

Radiation Induced-Phosphorylation of TRIP13 drives Radiation Resistance in Oral Cancer Banerjee, R., Liu, M., Schmitd, L.B., Singh, P., Hutchinson, M-K., Mierzwa, M., D’Silva, N.J. Presenter: Rajat Banerjee Faculty: Nisha D’Silva POM - Periodontics and Oral Medicine Funding: Grant Support (NJD): NIH/NIDCR DE027551 and NIH/NCI CA250214 Research Day 5

POSTERS 24

Single-Cell Transcriptomics Identifies Hypoxic-inducible Factors Activation in Efferocytic Macrophages

Mendoza-Reinoso, V., Schnepp, P., Rubin, J., Baek, D.Y., Kurutz, A., Keller, E., McCauley, L.K., Roca, H. Presenter: Veronica Mendoza-Reinoso Faculty: Laurie K. McCauley POM - Periodontics and Oral Medicine Funding: NIH/NCI P01-CA093900

How Did COVID-19 Affect First Year Dental Students’ Career Considerations? A Survey Lints, R.D., Inglehart, M.R.

Dental, Dental Hygiene and College Students’ Responses to Group Assignments Alsomairi, Y., Inglehart, M.R. Presenter: Yunus Alsomairi Faculty: Marita R. Inglehart POM - Periodontics and Oral Medicine

Dental Students with vs. without a Post Bac Program Experience: Analyzing Post Bac Experiences and Comparing Attitudes towards Post Bac Programs Niazi, A.A., Inglehart, M.R.

Presenter: Jaerae J. Dell Faculty: Marita R. Inglehart POM - Periodontics and Oral Medicine Funding: The Pathway Program funded this research.

Educating Dental Students, Staff and Faculty about Treating Patients from LGBTQ+ Backgrounds: Developing an Educational Intervention

Presenter: Nolan Wendling Faculty: Marita R. Inglehart POM - Periodontics and Oral Medicine

Therapy Dogs in Dental Offices: Dentists’ Considerations in Times of COVID vs. Before Vermeer, H.K., Inglehart, M.R. Presenter: Hannah K. Vermeer Faculty: Marita R. Inglehart POM - Periodontics and Oral Medicine Funding: This research was supported by the Pathways Program of the University of Michigan School of Dentistry.

6 Research Day

Presenter: Jade A. Gilbert Faculty: Marita R. Inglehart POM - Periodontics and Oral Medicine

Predoctoral Dental Students and Intimate Partner Violence related Education, Knowledge, Attitudes and Barriers to Action: A Survey Presenter: Rachel I. Teitelbaum Faculty: Marita R. Inglehart POM - Periodontics and Oral Medicine

Michigan Dental Students’ Knowledge, Attitudes and Behavioral Intentions Concerning Dental Therapists

Dental Students’ Diet-related Personal and Academic Experiences and Professional Behavior Jia, J., Sweier, D., Inglehart, M.R. Presenter: Jingqi Jia Faculty: Marita R. Inglehart POM - Periodontics and Oral Medicine

Dental Students and Patients with Special Health Care Needs: An Exploration of Educational Experiences and Professional Behavior Smith, D.E., Salzmann, L.B., Inglehart, M.R. Presenter: Dana E. Smith Faculty: Marita R. Inglehart POM - Periodontics and Oral Medicine

Exploring Oral Health Considerations of Veterans in the Western Upper Peninsula of Michigan: A Pilot Study

Presenter: Jad Majzoub Faculty: Hsun-Liang Chan POM - Periodontics and Oral Medicine Funding: Periodontal Graduate Student Research Fund

Presenter: Matthew Galli Faculty: Hom-Lay Wang POM - Periodontics and Oral Medicine

Presenter: Shayan Barootchi Faculty: Hsun-Liang Chan POM - Periodontics and Oral Medicine Funding: NIH/NIDCR R21 grant (1R21DE027765 – 01A1 and 1R21DE029005-01A1) NIH/NCATS (UL1TR000433) Delta Dental Foundation (AW)

Presenter: Miranda R. Haas Faculty: Marita R.. Inglehart POM - Periodontics and Oral Medicine

The influence of the interaction between staging, grading, and extent on tooth loss due to periodontitis

Improving Dental Ultrasound Workflow with a Deep-learning Segmentation Model Pan, Y.C., Kong, X.B., Hadjiiski, L., Kripfgans, O., Chan, H-L.

Ravidà, A., Qazi, M., Rodriguez, M.V, Galli, M., Saleh, M.H.A., Troiano, G., Wang, H-L. Presenter: Andrea Ravida Faculty: Hom-Lay Wang POM - Periodontics and Oral Medicine Funding: This manuscript was partially supported by the University of Michigan Periodontal Graduate Student Research Fund

Ultrasonographic Characterization and Tissue Perfusion Analysis of Implant Health and Disease: a cross-sectional study Barootchi, S., Tavelli, L., Wang, H-L., Chan, H-L., Kripfgans, O.

Oncology Residents, Fellows and Clinicians’ Considerations Concerning Dental Clearance: An Exploration Haas, M.R., Munz, S., Inglehart, M.R.

Maintenance regularity differentially impacts periodontitis-related tooth loss according to staging and grading Galli, M., Ravidà, A., Saleh, M., Rodriguez, M., Qazi, M., Troiano, G., Chan, H-L., Wang, H-L.

LaTendress, K., Hamerink, H., Inglehart, M.R. Presenter: Katherine LaTendress Faculty: Marita R. Inglehart POM - Periodontics and Oral Medicine Funding: The Pathways Program supported this study financially.

Multivariate Outcome Evaluation of Periodontal Osseous Defects Treated with Non-Surgical Mechanical Therapy Alone or Combined with Open Flap Debridement: A Retrospective Study Majzoub, J., Salami, A., Barootchi, S., Tavelli, L., Wang, H-L., Chan, H-L.

Periodontists and Stem Cell Based Bone Grafting: A National Survey Presenter: Jonathan Misch Faculty: Marita R. Inglehart POM - Periodontics and Oral Medicine Funding: This research was supported by NIH funding.

Sanchez, G., Inglehart, M.R. Presenter: Gino Sanchez Faculty: Marita R. Inglehart POM - Periodontics and Oral Medicine

Misch, J., Kaigler, D., Inglehart, M.R.

Teitelbaum, R.I., Inglehart, M.R.

Garcia-Ortega, D., Salzmann, L.B., Inglehart, M.R. Presenter: Diego Garcia-Ortega Faculty: Marita R. Inglehart POM - Periodontics and Oral Medicine

Dental Students’ Education and Career Considerations Related to Orthodontics: A National Survey

Profile for Success Program: Exploring Former Participants’ Career Development Gilbert, J.A., Ester, T.V., Inglehart, M.R.

Wendling, N.A., Kim-Berman, H., Inglehart, M.R.

Presenter: Ayesha A. Niazi Faculty: Marita R. Inglehart POM - Periodontics and Oral Medicine

Dell, J.J., Inglehart, M.R., Ester, T.V.

Presenter: Ryan D. Lints Faculty: Marita R. Inglehart POM - Periodontics and Oral Medicine

Michigan Dental Association Members’ Stress and COVID-19 Caused Concerns: Does Age, Gender and Ethnicity Matter?

Presenter: Ying-Chun Pan Faculty: Hsun-Liang Chan POM - Periodontics and Oral Medicine Funding: NIH 1R21DE029005-01A1, NIH 1R21DE027765-01A1

Dental Hygiene Students in Associate vs. Bachelor Degree Programs and Carrier Motivation and Satisfaction: A National Survey Rabeeah, Z., Carreno, J., Kinney, J., Inglehart, M.R. Presenter(s): Zainulabdeen Rabeeah, Jocelif Carreno Faculty: Marita R. Inglehart POM - Periodontics and Oral Medicine

Research Day 7

POSTERS 46

DDR2 Function in Chondrogenesis Singh, N., Ge, C., Mohamed, F., Franceschi, R. Presenter: Nita Singh Faculty: Renny T. Franceschi POM - Periodontics and Oral Medicine Funding: NIH/NIDCR K12 (NS), NIH R21 DE029012 (RTF), DOD W81XWH2010571 (RTF)

Sclerostin antibody stimulates periodontal regeneration in alveolar bone defect Sarment, L., Yao, Y., Kauffmann, F., Maekawa, S., Sugai, J., Schmiedeler, C., Doherty, E., Holdsworth, G., Kostenuik, P., Giannobile, W. Presenter: Lea Sarment Faculty: Suncica Travan POM - Periodontics and Oral Medicine

The Effects of Age and Smoking on Alveolar Bone Derived Stem Cell (aBMSC) Isolation and Growth

Apoptotic Cell Engulfment Induces Changes in Macrophage Nuclear Morphology and Transcriptional Regulation Pathways

Multiphasic, Highly-ordered and Personalized Scaffolds via 3D Melt Electrospinning Writing for Coordinated Periodontal Regeneration

Are Digital Complete Dentures Accurate? A Review of Literature

Digitally-Guided Tooth Preparation: A Controlled and MinimallyInvasive Approach

Evc2 Function In Mesenchymal (Neural Crest Cells Derived) Tissue Is Critical For Molar Morphology Chinoy, A., Louie, K., Zhang, H., Mishina, Y. Presenter: Afriti Chinoy Faculty: Yuji Mishina BMSP - Biologic and Materials Sciences & Prosthodontics Funding: R01DE020843 (YM), R03DE027456 (HZ), F30DE029667 (KL)

Yao, Y., Kauffmann, F., Raymond, J., Sugai, J., Maekawa, S., Lahann, J., Giannobile, W. Presenter: Yao Yao Faculty: William Giannobile POM - Periodontics and Oral Medicine Funding: NIH/NIDCR U24 DE026914

Presenter: Jingwen Yang Faculty: Yuji Mishina BMSP - Biologic and Materials Sciences & Prosthodontics Funding: R01DE020843

TGF-beta Activated Kniase 1 (TAK1) vitally Regulates Heterotopic Ossification (HO) in Fibrodysplasia Ossificans Progressiva (FOP) Mouse Models

Skeletal site-specific impacts of loss of BMP signaling through BMPR1A in osteoblasts on bone homeostasis: jawbone versus long bone Presenter: Maiko Omi Faculty: Yuji Mishina BMSP - Biologic and Materials Sciences & Prosthodontics

A Neural Control Circuit for Coughing Gannot, N., Phillips, C., Li, X., Emery, C., Li, P.

Essential Roles For BM-associated Components During The Secretory Stage Of Enamel Formation

Pore Curvature Regulates Mesenchymal Stem Cell Fate in Macroporous Tissue Engineering Scaffolds Presenter: Ben Swanson Faculty: Yuji Mishina BMSP - Biologic and Materials Sciences & Prosthodontics Funding: NIH NIDCR R01-DE027662, NIH NIDCR F30-DE029359

Peptide DPI-VTK promotes migration of MSCs Madsen, E., Wahlsten, M., Kohn, D. Presenter: Eric Madsen Faculty: David Kohn BMS - Biologic and Materials Science Funding: NIH T32 DE007057; R01 DE 026116; F30 DE028465

HDAC1 Identified as SOX10 Binding Partner in Salivary Gland Epithelial Stem Cells Jones, C., Carson, A., Athwal, H., Lombaert, I. Presenter: Christina Jones Faculty: Isabelle Lombaert BMSP - Biologic and Materials Sciences & Prosthodontics Funding: NIH/NIDCR T32-DE007057, RMF

Is PEEK material a Good Alternative for Dental Implant abutment(S) and Fixed Framework(S)? Seblani, D., Tarrazzi, D., Saglik, B. Presenter: Duaa Seblani Faculty: Berna Saglik Biologic and Materials Sciences & Prosthodontics

Relationship between the number of patients treated and the productivity of Dental Students Xie, D., Kadhium, V., Fitzgerald, M., Dauda, O., Dault, J.T., Nalliah, R.P.

Presenter: Tian Liang Faculty: James P. Simmer BMSP - Biologic and Materials Sciences & Prosthodontics Funding: NIDCR DE015846

Presenter: Haichun Pan Faculty: Yuji Mishina BMSP - Biologic and Materials Sciences & Prosthodontics Funding: R01GM123069, R01DE020843

Presenter: Hiroki Ueharu Faculty: Yuji Mishina BMSP - Biologic and Materials Sciences & Prosthodontics

Presenter: Harleen K. Athwal Faculty: Isabelle Lombaert BMSP - Biologic and Materials Sciences & Prosthodontics Funding: NIH/NIDCR F30 DE027605

Liang, T., Hu, Y., Smith, C.E., Simmer, J.P., Hu, J.C.

Impact on salivary glands from SARS-CoV-2 infection Athwal, H., Lombaert, I.M.A.

Presenter: Noam Gannot Faculty: Peng Li BMSP - Biologic and Materials Sciences & Prosthodontics Funding: School of Dentistry, Oral Health Sciences Program

Swanson, W.B., Omi, M., Nam, H.K., Ma, P.X., Hatch, N.E., Mishina, Y.

Enhanced BMP signaling induced ectopic X chromosome inactivation via increasing Xist expression, resulting in ectopic cartilage formation in the head

Omi, M., Mishina, Y.

Pan, H., Hwang, C., Liu, Y., Pagani, C., Levi, B., Mishina, Y.

Ueharu, H., Yang, J., Pan, H., and Mishina, Y.

8 Research Day

Presenter: Reem Helal Faculty: Daler E. Tarrazzi BMSP - Biologic and Materials Sciences & Prosthodontics

Kannan, R., Roca, H., Matera, D.L., Koh, A.J., Keller, E.T., Baker, B.M., McCauley, L.K. Presenter: Rahasudha Kannan Faculty: Laurie K. McCauley POM - Periodontics and Oral Medicine Funding: NIH R01DE022327-07

Yang, J., Nakamura, M.T., Hallett, S., Mishina, Y.

Helal, R., Aly, M., Saglik, B., Tarrazzi, D.

BMP signaling orchestrates a glucose metabolic program required for midline facial development

Presenter: Amna Alwalie Faculty: Berna Saglik BMSP - Biologic and Materials Sciences & Prosthodontics

Presenter: Manasa Bhavana Faculty: Berna Saglik BMSP - Biologic and Materials Sciences & Prosthodontics

Alwalie, A., Saglik, B., Tarrazzi, D.

Bhavana, M., Tarrazzi, D., Saglik, B.

Sommer, C., Chen, C., Dahlkemper, A., and Kaigler, D. Presenter: Celia Sommer Faculty: Darnell Kaigler POM - Periodontics and Oral Medicine Funding: NIH R01DE028657

Retrospective Chart Review of Implant Retained Removable Partial Dentures: Success Rates and Modes of Failure

Presenter: Di Xie Faculty: Romesh Nalliah CRSE - Cariology, Restorative Sciences and Endodontics

Inhibiting BMI-1 by PTC-596 ablates cisplatin-resistant Adenoid Cystic Carcinoma Stem cells Sahara, S., Warner, K.A., Zhang, Z., Nor, J.E. Presenter: Sosuke Sahara Faculty: Jacques E. Nor CRSE - Cariology, Restorative Sciences and Endodontics Funding: R01-DE21139 from the NIH/NIDCR (JEN)

Prescribing Guidelines Survey of US Dental Deans Hagood, K., Kenney, B., Kadhium, V., Rieck, H., Brummett, C., Nalliah, R.P. Presenter: Katelyn Hagood Faculty: Romesh Nalliah CRSE - Cariology, Restorative Sciences and Endodontics

Research Day 9

POSTERS 69

Variability in Caries Management Decision-Making In a Dental School Setting Booth, E., Eckert, G., Fontana, M. Presenter: Evan Booth Faculty: Margherita Fontana CRSE - Cariology, Restorative Sciences and Endodontics

Older Adults’ Knowledge about Dry Mouth: Evaluating an Educational Intervention

Emergency Department visits due to Dental Problems in Michigan

Presenter: Arwa Daghrery Faculty: Marco Bottino CRSE - Cariology, Restorative Sciences and Endodontics Funding: NIH R01DE026578

Presenter: Viyan Kadhium Faculty: Romesh Nalliah CRSE - Cariology, Restorative Sciences and Endodontics

74 Do Mission Statements Matter? An Evaluation of Dental School Mission Statements Kadhium, V.S., Betteg, S., Sharma, P., Nalliah, R.P.

Presenter: Hwa Kyung Nam Faculty: Nan Hatch Ortho/Peds - Orthodontics and Pediatric Dentistry Funding: NIH/NICDR 1R01DE02582701 (NH)

Effectiveness, Efficiency, and User Experience of 3D Virtual Tooth Identification Exam

Ohkura, N., Nam, H.K., Hatch N.E.

Presenter: Esther Suh Faculty: Hera Kim-Berman Ortho/Peds - Orthodontics and Pediatric Dentistry

Presenter(s): Naoto Ohkura, Hwa Kyung Nam, Nan E Hatch Faculty: Nan E Hatch Ortho/Peds - Orthodontics and Pediatric Dentistry Funding: NIH DE025827

Trends in Antibiotic Prescribing among Dentists at an Academic Health Center Presenter(s): Houd Mashrah, Pranshu Sharma, Viyan Kadhium Faculty: Romesh Nalliah CRSE - Cariology, Restorative Sciences and Endodontics

Presenter: Celia Le Faculty: Lucia Cevidanes Ortho/Peds - Orthodontics and Pediatric Dentistry Funding: NIDCR R01024450

Most common treatments in all age groups Sharma, P., Kadhium, V.S., Josan, N., Dault, J.T., Nalliah, R.P. Presenter: Pranshu Sharma Faculty: Romesh Nalliah CRSE - Cariology, Restorative Sciences and Endodontics

Web-based Automated Machine Learning Mandibular Segmentation Le, C., Deleat-Besson, R., Cevidane, L., Al Turkestani, N., Bianchi, J., Gurgel, M., Ruellas, A., Yatabe, M., Massaro, C., del Castillo, A., Benavides, E., Soki, F., Griak, J., Najarian, K., Soroushmehr, R.

Mashrah, H., Sharma, P., Kadhium, V.S., Dault, J.T., Nalliah, R.P.

Clinical Decision Support Systems in Dentistry

Web-based automated machine learning root canal segmentation Deleat-Besson, R., Le, C., Cevidanes, L., Al Turkestani, N., Bianchi, J., Gurgel, M., Ruellas, A., Yatabe, M., Massaro, C., del Castillo, A., Benavides, E., Soki, F., Griak, J., Najarian, K., Soroushmehr, R.

Presenter: Najla Al Turkestani Faculty: Lucia Cevidanes Ortho/Peds - Orthodontics and Pediatric Dentistry Funding: NIDCR R01024450

Impact of TNAP deficiency in cranial neural crest cells on craniofacial skeletal development

Suh, E., Kim-Berman, H., Karl, E., Ramaswamy, V.

Al Turkestani, N., Deleat-Besson, R., Le, C., Zhang, W., Prieto, J., Bianchi, J., Yatabe, M., Benavides, E., Soki, F., Soroushmehr, R., Cevidanes, L.

The Effect of Bleaching on Postoperative Hypersensitivity: A Literature Review Presenter: Abdulrahman Amr Alamoudi Faculty: Berna Saglik BMSP - Biologic and Materials Sciences & Prosthodontics

Experimental characterization of aerosol behavior and mitigation strategies in large, open-plan, dental clinics Kadhium, V.S., Zhu, M., Medina, M., Bell, E., Han, T., Boehman, A., Capecelatro, J., Wooldridge, M.S., Nalliah, R.P.

Rescue of Craniofacial Abnormalities in the TNAP-/- Mouse Model of Hypophosphatasia by Deletion of Enpp1 Correlates with FGF23 Levels Nam, H.K., Hatch, N.E.

Presenter: Ashlynn B. Schiro Faculty: Marita R. Inglehart Ortho/Peds - Orthodontics and Pediatric Dentistry

Al-Amoudi, A. , Saglik, B., Tarrazzi, D.

Basu, T., Chang, C., Nalliah, R. Presenter: Tanima Basu Faculty: Romesh Nalliah CRSE - Cariology, Restorative Sciences and Endodontics Funding: Department support

Schiro, A.B., Salzmann, L.B., Inglehart, M.R.

Injectable β-cyclodextrin/Dexamethasone Inclusion Complex-laden Hydrogel for Mineralized Tissue Regeneration Presenter: Saidah Tootla Faculty: Marco Bottino CRSE - Cariology, Restorative Sciences and Endodontics Funding: NIH RO1DE026578

Presenter(s): Oluwatobi Dauda, Viyan Kadhium, Pranshu Sharma Faculty: Romesh Nalliah CRSE - Cariology, Restorative Sciences and Endodontics

Association between Periodontal Care and Acute Myocardial Infarct Hospitalization and Post-Acute Care

Dental Students and Pediatric Residents’ Responses to Community-based Education about Treating Children and Adults with Special Health Care Needs A Program Evaluation

Tootla, S., Daghrery, A., de Souza, I.J., Bottino, M.C.

Nalliah, R.P., Dauda, O., Kadhium, V.S., Patel, V., Sharma, P., Xie, D., Patel, D., Smiddy R.

Daghrery, A., Ferreira, J.A., de Souza Araújo, I.J, Clarkson, B.H., Bhaduri, S.B., Malda, J., Bottino, M.C.

Burch, K., Tenuta, L., Inglehart, M.R., Suh T., Karl, E. Presenter: Karoline Burch Faculty: Livia Tenuta & Marita R. Inglehart CRSE - Cariology, Restorative Sciences and Endodontics Funding: Rackham Graduate Student Fund; MCubed Funding

Fluorinated-CaP Nanocoated Poly (ε-caprolactone) Melt Electrowritten Scaffold for Periodontal Tissue RegenerationFluorinated-CaP Nanocoated Poly (ε-caprolactone) Melt Electrowritten Scaffold for Periodontal Tissue Regeneration

Presenter: Romain Deleat-Besson Faculty: Lucia Cevidanes Ortho/Peds - Orthodontics and Pediatric Dentistry Funding: NICDR R01024450

Contribution of PTHrP-expressing chondrocytes in the cranial base synchondrosis Hallett, S.A., Ono, N. Presenter: Shawn Hallett Faculty: Noriaki Ono Ortho/Peds - Orthodontics and Pediatric Dentistry Funding: NIH/NIDCR T32-DE007057, NIH DE007057-44, OPD Department Support

Injection of Nitric Oxide Nanoparticles Inhibits Orthodontic Tooth Movement Crawford, D., Frost, M., Nam, H.K., Hatch, N. Presenter: Derrick Crawford Faculty: Nan Hatch Ortho/Peds - Orthodontics and Pediatric Dentistry Funding: LeGro Research Award (G025120), Rackham Graduate Student Research Grant

Presenter: Viyan Kadhium Faculty: Romesh Nalliah CRSE - Cariology, Restorative Sciences and Endodontics

10 Research Day

Research Day 11

Weivoda Lab Margaret Durdan Description: Confocal microscopy of osteoclasts immune response to ovalbumin. Multinucleated osteoclasts (green) communicate by extending cellular appendages and respond to antigens with surface markers CD80 and MHCII (yellow). 12 Research Day

Research Day 13

Bottino Lab Arwa Daghrery & Marco Bottino Description: Scanning electron microscopy characterization of alveolar bone marrow-derived mesenchymal stem cells on novel highly ordered nanostructured fluorinated CaP-coated Melt ElectroWritten scaffold for personalized bone tissue engineering. 14 Research Day

Research Day 15

Ono Lab Shawn Hallett & Noriaki Ono Description: Fgfr3-labeled chondrocytes and osteoblasts (red) are distributed throughout the cartilaginous growth center synchondroses in the cranial base. Col1a1+ osteoblasts (green) dispersed throughout the basisphenoid bone are surrounded by cell nuclei (gray). 16 Research Day

Research Day 17

Kohn Lab Eric Madsen and David Kohn Description: High magnification scanning electron micrograph of the surface of biomimetic apatite. This carbonated hydroxyapatite mimics the natural composition of native bone mineral and can be precipitated in thin films on biodegradable polymers to form scaffolds for bone tissue engineering. 18 Research Day

Research Day 19

Tenuta Lab Livia Tenuta Description: Determination of fluoride concentration in 100 nanoliter drops of dental biofilm fluid. Samples are applied on the surface of a fluoride electrode using micropipettes. A micro reference electrode is shown touching one of the drops. Analyses are conducted under mineral oil (to avoid evaporation) with the aid of a stereomicroscope. 20 Research Day

Research Day 21

Mishina Lab Jingwen Yang & Yuji Mishina Description: Neural crest cells (red) migrate to populate a head of day 9 mouse embryo. Neural crest cells are labeled by R26RTdTomato with P0-Cre as red. pH3 immunostaining (green) reveals proliferating cells, DAPI stains nuclei (blue). Top, posterior, bottom, anterior. 22 Research Day

Research Day 23

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My Community Dental Centers (MCDC) Research Day 25

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26 Research Day

Research Day 27

CONGRATULATIONS

to the University of Michigan School of Dentistry award recipients and participants. The Delta Dental Foundation is proud to support programs and services that improve oral and overall health, promote health equity, and enhance the quality of life in our communities.

Thank you and we’ll see you at Research Day 2022!

www.deltadentalmi.com/ddf 28 Research Day

Research Day 29

Office of Research and Research Training | 1011 N. University, Room G306 | Ann Arbor, MI 48109-1078 | dent-researchday@umich.edu