Personalized breast care for life

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VISIONARY BREAST CENTERS

CANON WORLDWIDE MEDICAL RESEARCH FOR MANKIND

DIGITAL IR GENOMIC CRYOABLATION FROM GENTESTIR, IRVINE CALIFORNIA PERSONALIZED BREAST CARE FOR LIFE FDA APPROVAL FEBRUARY 2004, 510(K) # 032350, THE PROCESS HAS BEEN USED IN PRIVATE PRACTICE FOR TEN YEARS BUT NEVER FULLY COMMERCIALIZED

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WHAT IS PERSONALIZED BREAST CARE? A Paradigm Shift in Women’s Health Care Advanced genetics techniques now can predict when a breast cancer will likely manifest within ten years coupled with multiple non-radiating technologies will allow us to identify ultra-small cancers and treat them in an office setting in 20 minutes, no surgery, no chemo and no radiation. It is low cost, mobile and will save millions of lives. Slide 2


TECHNOLOGIES        

Pharmacogenomics Modified Military Digital Infrared with artificial intelligence Ultrasound with Elastography Halo Hand held pressure sensing device Cryoablation Breast Voyager Slide 3


PHARMACOGENOMICS • • • • •

OncoVue Breast cancer risk test by InterGenetics FDA approved DNA saliva test, clinical trial ICI-103, done once in a lifetime Tells risk and when risk will likely manifest within ten years Looks at abnormal combinations of ‘SNPs’ single nucleotide polymorphisms in the Double Helix

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MODIFIED MILITARY INFRARED FLIRs A40 camera  Patient sits topless 4ft from cooling device which houses an 8000BTU unit  IR results in 4 minutes by computer Exploits Zeroth Law of Thermodynamics  10 scoring areas including Neural Network (artificial intelligence) 

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SURETOUCH Laptop portable and hand held device  No radiation  Results available immediately  Can image the entire breast plus axilla  Can lock unto sub five mm masses  Low cost 

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HALO Collects NAF (nipple aspirate fluid) by gentle suction  Gives information to cellular workings, a biopsy without a biopsy (PAP test)  Low cost  Combine with OncoVue and IR  Can pick up sub mm cancer cells  Portable 

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ELASTOGRAPHY Moderate cost  Portable  Harmonic Ultrasound in color/cine  Results available immediately  Measures different stress on tissue adjacent to an evolving breast entity cyst vs. cancer  No radiation 

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ICECURE 3mm cryogenic probe  Liquid nitrogen -190 degrees F  Three cycles – freeze, thaw, freeze  10 to 20 minute in office procedure  Mobile, low cost, DEFINITIVE  Dr. Eisuke Fukuma’s data chairman of breast center at Kameda Medical Center, Japan 

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OVERALL PLAN -FOR CANON TO PARTNER WITH US To acquire all these technologies, including the hand held device (that could be marketed on television), create treatment, education, certification and black box research centers. Worldwide people would know Canon took the time to create this paradigm shift for all women. Slide 19


THE SOLUTION Through six years of research we found that the melding of our non-radiation technology allows breast cancer to be treated in one day without traditional surgery, chemotherapy or radiation. THIS IS PARADIGM SHIFTING

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RESULTS OF FIRST 500 PATIENTS      

Sensitivity 96% Specificity 79% MRI and IR agreed 77% 23% of the time they disagreed, however, IR proved 100% correct as time went on 84% of the time IR was negative, that combined with low genetics risk equals no further testing 5 cancers outside the breast were found including two asymptomatic lung cancers and skin cancer Slide 21


CRYOABLATION To date we have performed 6 cryoablation procedures, most on recurrent cancers instead of mastectomy. This is a first in the world. Biopsies after show 100% cancer kill, no surgery, no chemotherapy, no radiation, no stitches, resume normal activity immediately Slide 22


JAPAN/AMERICAN COMBINED EFFORT TO DEFEAT BREAST CANCER SPONSORED BY CANON

Dr. Fukuma in Japan is the most experienced in the world using cryoablation on breast cancer. We are the most experienced finding ultra-small breast cancer 3-5mm using non-radiation technology which is highly accurate and low cost. Working together would show the world this new paradigm and save millions of women in years to come. Slide 23


CANON MEDICAL RESEARCH

DEMO AND DOCTOR’S TRAINING CENTER IN IRVINE AND La QUINTA, CALIFORNIA

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CANON GLOBAL MEDICAL RESEARCH Watashi wa junbi ga dekite tatte iru Wareware wa kore o okonau koto ga dekimasu Seki wa Kiyanon o oboette irudarou Domo arigatou gozaimasu Phillip Bretz, M.D. The End


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