The Science of
Practitioner Guide
15+
Years of research
In collaboration with the Swiss Federal Institute of Technology de Lausanne (EPFL)
11
Human clinical trials
Completed and ongoing clinical trials involving over 900 participants
Cell aging starts in our 30s
Mitochondrial decline and disabled macroautophagy are hallmarks of aging
*Muscle function as a proxy for quality of life.
Earlier interventions are needed at a foundational level to maintain cellular energy and vitality.
is a highly pure form of Urolithin A, a postbiotic clinically shown to energize cells, increase muscle strength and improve endurance. It revitalizes mitochondria by triggering mitophagy, a vital cellular recycling mechanism responsible for maintaining optimal cellular function. 30s
Quality
life* 0 10 20 40 50 60 Average aging Healthy aging 70 80 90 100 Age
of
Mitochondria are the bedrock of good health
Healthy cells rely on healthy mitochondria. Mitochondria are our cellular powerhouses and produce 90% the energy our bodies need. Their optimal function leads to incredible health benefits, and is particularly essential to heart, kidney, eye, brain and muscle function.
Click to go to: D’Amico et al. (2021). Impact of the natural compound Urolithin A on health, disease, and aging. Trends in Molecular Medicine, 27 (7).
Brain Joints Gut Health Immune System Heart MuscleImproves biomarkers of mitochondrial function in skeletal muscle
Supplementation with 500mg and 1000mg of Mitopure® in sedentary adults demonstrated similar mitochondrial activity to that of habitually active adults.
Mitopure® induced mitochondrial gene expression similar to aerobic exercise regimens.
Mitochondrial Health Poor Good
Click to go to: Andreux et al. (2019) The mitophagy activator Urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans. Nature Metabolism; 1:595-603.
Placebo 500mg of Urolithin A 1000mg of Urolithin AMost people cannot make Urolithin A
Only 12% of people had Urolithin A in their system at the start of the trial and only 40% of people naturally produced Urolithin A from precursor molecules such as ellagitannins in pomegranate juice.
T0 Baseline T6h post intake T24h post intake
Non-Producer (no detectable UA-Glucuronide)
Low-Producer (5-100ng/mL UA-Glucuronide)
High-Producer (>100ng/mL UA-Glucuronide)
Mitopure® provided a 6-fold increase of Urolithin A in the blood compared to pomegranate juice intake.
Click to go to: Singh et al. (2021). Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the population. Euro J Clin Nutr, 76; 297-308.
Total
Total
Total = 100
= 100
= 100
87.80% 10.20% 2.00% 72.20% 23.70% 4.10% 32.70% 26.50% 40.80% 0 100 200 300 400 500 600 700 800 500mg Mitopure™ Diet
Improves muscle endurance and strength in middle-aged adults
Middle-aged adults (ages 45-65 years) were supplemented with either 500mg or 1000mg of Mitopure® or a placebo for 4 months. The 500mg group saw a 12% increase in hamstring strength compared to placebo. The 1000mg group saw a 9.8% increase in hamstring strength, a 5.1% increase in grip strength, a 10% increases in peak VO2, and a 7% improvement in 6-minute walk test.
Both Mitopure® groups demonstrated improvements in biomarkers of cellular health and inflammation, including a reduction in CRP. No diet or exercise interventions were part of the study.
Click to go to: Singh et al. (2022) Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. Cell Reports Medicine, 3, 100633.
Hamstring muscle strength Placebo UA 500 mg UA 1000 mg Change in average peak torque (Nm) p = 0.027 p = 0.029 -40 -30 -20 -10 0 10 20 30 40 VO2 Peak Placebo UA 500 mg UA 1000 mg Change in peak VO2 (ml/kg/min) -20 -10 0 10 20 p = 0.058 Placebo UA 500 mg UA 1000 mg -10 -5 0 5 10 15 Hand grip strength Change in hand grip muscle str eng th (kgs ) -300 -200 -100 0 100 200 Change in 6-min ut ew al kd is tanc e (meter s) 6-minute walk Placebo UA 500 mg UA 1000 mg p = 0.098
Improves physical performance and muscule endurance in older adults
Older adults (ages 65-90 years) were supplemented with 1000mg of Mitopure® or placebo for 4 months.
The Mitopure® group saw improvements in 6-minute walk distance (increased 60.8 meters from baseline) compared to placebo.
The Mitopure® group saw significant improvements in muscle endurance, exemplified by an increase in the number of muscle contractions until fatigue from baseline in the first dorsal interosseus (FDI) and tibialis anterior (TA) at 2 months.
The Mitopure® group demonstrated improvements in biomarkers of cellular health and inflammation, including a reduction in CRP levels. Participants did not make changes to diet or exercise during the study. Click to go to: Liu et al. (2020) Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in
Older
Randomized Clinical
JAMA Network Open;
600 200 400 0 –200 –400 No of peaks Absolute change in contractions in FDI muscle from baseline to 2 mo and to 4 mo Baseline to 4 mo Baseline to 2 mo a Placebo Urolithin A 0.8 0. 6 0. 4 0. 2 0 No of contractions Time, ms Contractions in FDI muscle from placebo 300 100 200 0 400 Baseline 2 mo 4 mo 0.6 0. 4 0. 2 0 No of contractions Time, ms Contractions in FDI muscle from urolithin A 300 100 200 0 400 Baseline 2 mo 4 mo 0.8 0. 6 0. 4 0. 2 No of contractions Time, ms Contractions in TA muscle from placebo 300 100 200 0 400 0 Baseline 2 mo 4 mo 0.8 0.6 0. 4 0. 2 No of contractions Time, ms Contractions in TA muscle from urolithin A 300 100 200 0 400 0 Baseline 2 mo 4 mo 600 200 400 0 –200 – 400 No . of peaks Absolute change in contractions in TA muscle from baseline to 2 mo and to 4 mo Baseline to 4 mo Baseline to 2 mo b c Placebo Urolithin A
Adults. A
Trial.
5(1).
Potent anti-inflammatory benefits
In middle-aged adults, administration of Mitopure® reduced plasma CRP levels at both 500mg and 1000mg doses. Statistically significant changes were seen with the 1,000 mg dose. In older adults, 1000 mg of Mitopure® significantly reduced levels of CRP.
Click to go to: Singh et al. (2022) Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults. Cell Reports Medicine, 3, 100633.
Click to go to: Liu et al. (2020) Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults. A Randomized Clinical Trial. JAMA Network Open; 5(1).
0 5 UA 500 mg UA 1000 mg Placebo 2.5 C hange to baselin e C-reactive protein (CRP) * 10 8 6 2 4 0 CRP , mg/ L Baseline 4 mo
A Placebo a
Urolithin
Our clinical program goes beyond muscle to study the impact of Mitopure® on the immune system, skin, joints and brain health.
Muscle
Skin Heart
Joints
Additional clinical programs are planned with top investigators from top Universities such as Harvard, NorthWestern, UCLA and McGill Universities.
Learn more about our latest trials
No adverse events were seen in clinical trials using Mitopure. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Brain
Immune