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The Chronicle T h e i n d e p e n d e n t d a i ly at D u k e U n i v e r s i t y
xxxxxday, mmmm wednesDAY, october xx, 16, 2013 2013
New cancer therapy uses poliovirus
www.dukechronicle.com
ONE ONE HUNDRED HUNDRED AND AND EIGHTH ninthYEAR, YEAR,Issue Issuexxx 34
Social app launches at local colleges
Duke beats Navy
by Melissa Zhang
by Jen Chen
The Chronicle
A new cancer therapy is currently under clinical trials at Duke’s Preston Robert Tisch Brain Tumor Center. This new approach involves injecting a brain tumor with modified poliovirus, which invades and kills cancerous brain cells while being harmless to normal brain cells. Nine patients have been successfully treated so far in phase one of the trial, which aims to determine a safe and effective dosage at which to treat patients, said Dr. Annick Desjardins, associate professor of neurology and principal investigator of the study. Dr. Matthias Gromeier, associate professor in the department of neurosurgery, began preclinical development of the modified poliovirus in 2002. More than 15 years of research went into the poliovirus therapy prior to starting clinical trials, which is not unusual, Gromeier said. “The absolutely essential prerequisite on the research side was a large monkey neurovirulence study,” he said, which tested the treatment on monkeys to establish the safety of the approach. Additional research was also done to determine how the poliovirus interacted with cancer cells. Another vital component before trials could begin was a modified poliovirus that infected cancer cells while having no effect on normal cells, which was developed by the National Institute of Health, Gromeier said. The first patient, Stephanie Lipscomb, found out she had stage four gioblastoma, the most lethal and common form of brain cancer, as a nursing student at age 20. Although chemotherapy was unsuccessful in eradicating the tumor entirely, the experimental poliovirus therapy was able to reduce the tumor to the size of a pea, Desjardins said. “She has a normal life as a nursing student,” Desjardins said of Lipscomb. “Looking at her, no one could imagine that she had been diagnosed with a terminal brain cancer. We cannot say that she is cured, but she is in remission for sure.” Currently, side effects of the poliovirus therapy are minimal, Gromeier said. “Thus far, the main side effects we have observed are due to the infusion of fluid into the brain of the patients See therapy, page 12
The Chronicle
Clinic and several hospitals, including the Duke Regional Hospital and Duke Raleigh Hospital. “Our main motive is to keep our patients safe—we don’t want a healthcare worker to be carrying the flu virus and accidentally infect a patient,” said Gail Shulby, chief of staff and clinical affairs for DUHS. The influenza vaccine is free for all students and staff with the presentation of legitimate Duke card, said Shelby Hill-McCray, a senior nurse for Employee Occupational Health and Wellness. Student Health, which operates under DUHS policies, has immunized over 2,800
A new social media app aims to bridge the gap between online and offline social interactions. The Bevii mobile application uses locational technologies to track the social life of its users and construct virtual social networks. It launched Monday and is now available exclusively for students at Duke, The University of North Carolina at Chapel Hill and North Carolina State University through iOS and Android platforms. “The idea came from being a social media user and being frustrated with the current options out there,” said Bevii founder Taylor Robinette, a sophomore at UNC. Networking sites such as Facebook create a secondary social sphere that separates social media from actual social life. Bevii connects the two worlds by including face-to-face and online social interaction. Robinette said. The Bevii app detects its users in close proximity and automatically adds them to each other’s base network. From there, Bevii organizes friendship into five levels—with one being close friends and five being the base level where people can only see each other’s names and profile pictures. These levels constantly adjust to correspond to the amount of interaction between individuals. Users have the option of moving their contacts along the scale without affecting where they are placed on that contact’s relationship list, Robinette said. “There is a significant amount of ‘Facebook fatigue’ out there, particularly on-campus, and I believe the window has cracked open for a new and relevant social media solution,” wrote Jim Kitchen, a lecturer in entrepreneurship at UNC’s Kenan-Flagler Business School and an investor in Bevii, in an email Sunday. As of Sunday, Bevii had received $300,000 of funding from investors. Robinette said the start-up aims to raise another 10 to 15 million dollars of venture capital by the first quarter of 2014. “The idea behind the Bevii app makes sense to me, but more importantly, I am investing in it because I am confident that Taylor is going to be successful,” said Merrill Mason, an investor and lawyer for Bevii. “It’s like what people say—you bet on the jockey and not the horse.”
See flu shots, page 12
See Bevii, page 12
Dayou zhuo/The Chronicle
Duke Football beat Navy 35-7 Saturday at Wallace Wade. See our sports coverage on page 13
Vaccinations spike due to new DUHS requirements by Anthony Hagouel The Chronicle
The Duke University Health System has experienced a dramatic increase in flu vaccinations this year following a major policy change in April. All DUHS employees must be vaccinated for the flu or have a legitimate medical or religious excuse by Dec. 6. This change may account for the 14,060 vaccines given out on Sept. 18th—a “blitz” vaccine day where thousands of employees tried to vaccinate as many healthcare employees as possible. Last year’s blitz resulted in 12,487 vaccinations. The Duke Health System is comprised of the Duke University School of Medicine, the Duke University School of Nursing, the Duke