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thursday, october 8, 2015
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ONE HUNDRED AND ELEVENTH YEAR, Issue 31
NOBEL IN DUKE’S DNA
Paul Modrich becomes second standing faculty member awarded the Nobel Prize
Quote and Image courtesy of Duke Today For the second time in four years, a Duke professor in biochemistry was awarded the Nobel Prize in Chemistry.
Abigail Xie The Chronicle Paul Modrich’s Nobel Prize win is a huge victory not only for him and for Duke, but also for all fields of basic research, administrators and colleagues said. Modrich—James B. Duke professor of biochemistry, member of the Duke Cancer Institute and Howard Hughes Medical Institute investigator—was awarded the 2015 Nobel Prize in Chemistry Wednesday, along with Aziz Sancar of the University of North Carolina at Chapel Hill and Tomas Lindahl of the Francis Crick Institute in the U.K. The researchers were honored for their discoveries of three different fundamental mechanisms of DNA repair—a critical process in maintaining the integrity of many organisms’ DNA. The research has potential applications in fighting cancer and other diseases. Modrich is the second standing faculty member in Duke’s history to win a Nobel Prize and also the second professor from the department of biochemistry, after Dr. Robert Lefkowitz, James B. Duke professor
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of medicine and professor of biochemistry and immunology, received the same award in 2012 for his work on G-protein-coupled receptors. “I have to say this acknowledgment is shared by graduate students and others in my lab. I want to thank the biochemistry department at Duke for giving me a scientific home,” Modrich said during a press conference held Wednesday at UNC to honor the Nobel Prize winners. Modrich called into the conference while away on vacation in New Hampshire. Modrich has been a Duke faculty member since 1976 and has studied the molecular machinery of DNA for most of his career, prompting Richard Brennan, James B. Duke professor of biochemistry and chair of the biochemistry department, to describe him as “a homegrown Duke biochemist.” Modrich’s discovery of the mismatch repair mechanism demonstrated how errors made during DNA replication are corrected and paved the way for further understanding of cancer and many other diseases. “This is the most exciting kind of honor that any university can get,” said Michael Schoenfeld, vice president for public affairs
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and government relations. “The fact that Professor Modrich was elected for the most prestigious science prize in the world is a great honor for him, but also a great honor and reflected glory to Duke and to all of the faculty and students who have worked with him over the years.” Nancy Andrews, dean of the School of Medicine, noted that Modrich’s work “is of fundamental importance to understanding cancer and other serious diseases.” “This is an extremely proud moment for Paul and his laboratory and for all of Duke and shines a spotlight once again on the outstanding science here,” she wrote in an email. Although the applications of Modrich’s work to cancer medicine and many other fields of biomedical research are significant, Lefkowitz noted that Modrich’s win is also a boost for basic science, which is the pursuit of understanding essential scientific processes and phenomena without focusing on immediate applications or treatments for diseases. “It is simply driven by the curiosity of a See NOBEL on Page 16
Serving the University since 1905
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NOBEL NOTES
• Modrich won the Nobel Prize in Chemistry—just as Professor Robert Lefkowitz did in 2012. • 3 researchers, including a UNC professor, shared the award this year for findings on DNA repair. • This is the second Nobel Prize win for both Duke and UNC. UNC’s Oliver Smithies won the first for the schools in 2007. • Modrich was on vacation in New Hampshire Wednesday and is expected to be back on campus later this week.
STUDENT OPINION ONLINE
• See what students think of the win compared to Duke men’s basketball’s latest championship.
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