Creative Biolabs| Lipid-based Drug Delivery
Liposome-based strategies across the BBB Liposomes are a type of nano-sized phospholipid bubbles that have attracted much attention as potential drug carriers. Liposomes are highly biocompatible and easy to control in vivo. Due to their unique physicochemical characteristics, liposomes can incorporate hydrophilic, lipophilic, and hydrophobic therapeutic agents, including a broad variety of drugs, DNA, and diagnostic agents. Hydrophilic compounds may either be entrapped into the aqueous core of the liposomes or located at the interface between the lipid bilayer and the external water phase. Lipophilic or hydrophobic drugs are generally entrapped almost completely in the hydrophobic core of the lipid bilayers of the liposomes.
Advantages of Liposome: • • Fig.3 Structure of liposomes. (Débora B Vieira, 2016)
•
Nano- or microsize vesicles Able to incorporate hydrophilic, lipophilic, and hydrophobic therapeutic agents. Good biocompatibility and biodegradability, low toxicity, drug-targeted delivery, and controlled drug release.