Ertebat Magazine Issue 1044 by Ertebat Publishing

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13th Year

ISSUE 1044

Sunday 11 June 2017

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News

CRISPR gene-editing tool causes unintended genetic mutations

It's not hyperbolic to say that the CRISPR-Cas9 gene-editing technique has been a revolutionary breakthrough, allowing scientists the ability to quickly, easily and precisely edit sections of DNA. But questions over how precise the CRISPR tool is have been raised in a new study from Columbia University Medical Center, which shows this gene-editing technology can introduce hundreds of unintended mutations into the genome.

&5,635 KDV VSDUNHG D Ã&#x20AC;XUU\ RI QHZ DYHQXHV of research around the world, from targeting FDQFHU WR +,9 ZLWK WKH Â¿UVW KXPDQ WULDOV LQYROYLQJ &5,635 HGLWHG FHOOV DOUHDG\ XQGHUZD\ LQ &KLQD and a US trial slated for 2018. But this new study urges caution moving forward, suggesting we are still yet to understand the greater genomic effects of the tool. ,Q H[DPLQLQJ WKH HQWLUH JHQRPH IURP WKH &5,635 treated mice, they found that the tool had successfully FRUUHFWHG WKH VSHFLÂ¿F JHQH WKH\ ZHUH WDUJHWLQJ but it also potentially caused a great deal of other

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JHQHWLF FKDQJHV ,Q WZR &5,635 WUHDWHG DQLPDOV more than 100 large gene deletions or insertions DQG RYHU VLQJOH QXFOHRWLGH PXWDWLRQV ZHUH LGHQWLÂ¿HG 0RVW VLJQLÂ¿FDQWO\ DOO RI WKHVH LGHQWLÂ¿HG PXWDWLRQV were not picked up by the general computer DOJRULWKPV PRVW UHVHDUFKHUV XVH WR ORRN DW WKH RII WDUJHW HIIHFWV RI &5,635 HGLWLQJ 7KHUH ZHUH QR obvious or immediately deleterious effects in the animals from these unexpected mutations, but it is unknown what longer term effects the altered genes could have. 6RXUFH 1HZ$WODV

Science

*UHDW %DUULHU 5HHI EOHDFKLQJ HYHQ ZRUVH WKDQ Ă&#x20AC;UVW thought The news has gone from bad to worse to "very concerning" for Australia's Great Barrier Reef, with the world's largest reef system suffering through a second consecutive coral bleaching event that is SURYLQJ HYHQ PRUH GHVWUXFWLYH WKDQ ÂżUVW SUHGLFWHG Coral bleaching takes place as a result of abnormal sea conditions, including both warmer and colder temperatures, which place stress on the algae living inside the coral. This can cause the coral to expel the algae, which is critical to its health, leaving them white, withering and in danger of dying. Prior to 2017, the Great Barrier Reef had suffered through three major bleaching events in modern history â&#x20AC;&#x201C; 1998, 2002 and 2016 â&#x20AC;&#x201C; and underwater and aerial surveys earlier this year indicated that 2017 would offer little reprieve, with VFLHQWLVWV FRQÂżUPLQJ EDFN WR EDFN EOHDFKLQJ HYHQWV were taking place. They had maintained hope that things would cool off quickly, but further surveys

have now revealed that seems unlikely, along with the true extent of the current damage.Scientists from the Great Barrier Reef Marine Park Authority have FRQÂżUPHG WKDW SHUFHQW RI VKDOORZ ZDWHU FRUDOV died from the bleaching in 2016, an increase on the 22 percent they had predicted midway through that year. Deeper coral was also affected, but divers are unable to systematically assess mortality rates at those depths. "We're very concerned about what this means for the Great Barrier Reef itself and what it means for the communities and industries that depend on it," said Great Barrier Reef Marine Park Authority Chairman Russell Reichelt. "The amount of coral that died from bleaching in 2016 is up from our original estimates and, at this stage, although reports are still being ÂżQDOL]HG LW V H[SHFWHG ZH OO DOVR VHH DQ RYHUDOO further coral cover decline by the end of 2017." 6RXUFH 1HZ$WODV

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ɄŶƾƴƘ ƽ ƲƻŶŽɇƞƞƀ ƹŷƞƞƀ ɄŚŻƙƞƞƄ żŚ · ŜŎ ƆƾƞƞƉŵŞ ŢśƞƞƙɆśƳ żŚ ɄźŚŷƞƞƨƳ óǇ ƂśȌƞƞƸȋ ƽ ŢźƾƞƞƅƳ · ɅƞƞƸɇǭ ƶŵƞƞƀ · ţƞƞŞŚŻƧ óǉ ɅƞƞưƴŭŤ ƽ ŻƞƞŴśƣ Ʉɽƞƞƻ ƹƾɇƞƞƄ · ſƞƞưŭƳ ɄʨśƞƞŞ · śȋźƾƞƞƯ śɇƞƞƀźśȘ ƾƞƞȌɆźŷƣ żŚ ɄŻƞƞŨŚ óǈ ɅŘśťƞƞƀƽź ƺƷśƞƞƁƣŚ ƹŶŽƞƞƷśǡ ƦƞƞƯśŴ ŶƾƞƞŴ żŚ ƽ ɽƞƞƷ · Ƶżƾƞƞƀ óǌ ŝɇƞƞƀŎ ƽ ƺƞƞƳŷƈ · ƵŷƞƞŞ ɄźƽŻƞƞƌ ŻƞƞƈśƸƘ żŚ · ƹśƞƞƅƷśƳŻȋ ƵśťƞƞƀŚ źŶ ɄŻƼƞƞƄ óǋ ƽŻƞƞƀ ţƞƞƤƈ · ƵŷƞƞƙƳ · ɅƞƞƻśşŤ ƽ ŶśƞƞƁƣ · Ȋƞƞǭƾȋ óǊ

ƱśƞƞŴź ȗƸƞƞƀ · ɄɿƞƞȘ ƺƞƞƄƾȘ · ŝƞƞƀŚ ȖŻƞƞŞ ƽ żśƞƞƀ óǎ ŢśƞƞƣŚɻƘŚ ƦƞƞƯśŴ ƽ ɄƾƞƞƁƷŚŻƣ ɅƞƞƳśƷ ơƾƞƞƁưɇƣ · ŢŚźƾƞƞŤ źŶ ŚŷƞƞŴ ƱśƞƞƷ · ƱźśƞƞƼǭ ȊƞƞɆ óǍ ɄźśƞƞŬ · ɅƞƞƌŚź ɅƞƞƘƾƷ · ɅƞƞƷśƼƸǡ Ƃżśƞƞƀ · ţƻśşƞƞƄ ŷƷƾƞƞƁǡ óǇǇ ȖźŽƞƞŞ ɄƽżźŎ · ɷʨŷťƞƞƀŚ ţƞƞƴȌŰ ƺƞƞŞ ŷƞƞƨťƙƳ · ƶɆɿƞƞƄ ƽ ƂŻƞƞŤ ƹƾƞƞɇƳ óǇǐ śƸũťƞƞƀŚ ƺƞƞƴưȋ · źśȋśƞƞɆź · ŜŽƞƞŰ ɹƞƞƻź óǏ žśƸƞƞƄ ƹśƞƞɇȘ óǇǋ ƾƞƞȌɇƷ ƽ ŜƾƞƞŴ · ƹśƞƞƳ żŚ ɅťƴƞƞƁƧ · ƮƞƞşƸŤ óǇǊ ƂƾƞƞŴ · ɅƞƞŞŻƘ ƺƞƞŞ ƵŚŻƞƞƁǡ · ɅƞƞƷśŞŻƼƳ óǇǉ ƵŚŶƾƞƞƀ · ƹŷƞƞƸƸȋ ɿƞƞƁƤŤ · źƾƞƞƴɇŤ ţƞƞƤƈ · ɄźśƞƞɆ óǇǈ ƺƞƞǭźśǡ ƵʩƞƞɇȘ źŶ ɄŻƼƞƞƄ · ǇǏ ƹŷƞƞƀ ɅƞƞƷśƴƯŎ

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I knew that was a bad idea, I told you so. ϡΩϮΑ ϪΘϔ̳ ΖϬΑ Ζδϴϧ ̶ΑϮΧ ̵ ϩΪϳ΍ ϢΘδϧϭΪϴϣ

Ζγ΍ ήΘϬΑ ϪϧΎΧ ˬΏήϏ Ύϳ ϕήη % j Ϫη ̶Ϥϧ ϡΩ΁ ̵ ϪϧϮΧ ϞΜϣ ΎΟ ̨ϴϫ %® Űs źŮŦ 8

Come on, you know better than that. ̶ϧϭΪϴϣ ήΘϬΑ ΕΩϮΧˬ εΎΑΩϭί

U ¢ ƀűƁŰ How much do you know about Ramadan? ˮΪϴϧ΍Ω ̶ϣ ϥΎπϣέ ϪΑ ϊΟ΍έ έΪϘ̩ It is considered the most venerated and blessed month of the Islamic year. Ωϭέ ̶ϣ έΎϤη ϪΑ ̶ϣϼγ΍ ϩΎϣ ϦϳήΗ ̭έΎΒϣ ϭ ϦϳήΗ αΪϘϣ ϩΎϣ Ϧϳ΍ The most prominent activity of this month is the daytime fasting. Ζγ΍ ίϭέ ϝϮσ έΩ ϦΘϓή̳ ϩίϭέ ˬϩΎϣ Ϧϳ΍ ϞϤϋ ϦϳήΗίέΎΑ When should people get up for fasting? ˮΪϧϮη έ΍ΪϴΑ Ώ΍ϮΧ ί΍ ϦΘϓή̳ ϩίϭέ ̵΍ήΑ ΪϳΎΑ ̶̯ ϡΩήϣ When do they break their fast? ˮΪϨϨ̯ ̶ϣ έΎτϓ΍ ̶̯

I have been burned by making bad decisions before. ̵ΪΑ ςϳ΍ή˰˰η ϮΗ ϡΩϮΑ ϪΘϓή̳ ϼΒϗ Ϫ̯ ̵ΪΑ ϢϴϤμΗ ήσΎΧ ϪΑ ϡΩΎΘϓ΍ I really want to know what happens so keep me in the loop." ϥΎϳήΟ ϮΗ ϢϨϣ β˰˰̡ ϩΩΎΘϓ΍ ̶ϗΎϔΗ΍ Ϫ̩ Ϣ˰˰ϧϭΪΑ ϡ΍ϮΨϴϣ Ύ˰˰όϗ΍ϭ Ϧ̯ ϡήΒΧΎΑ έ΍ΰΑ Going to the movies sounds good, I'm down. ϢΘδϫ ϢϨϣ ϢϳΎ̡ Ϧϣ ϪΑϮΧ ̶ϠϴΧ ϦΘϓέ ΎϤϨϴγ If you can just get to the point maybe I can help you. ϢϨ̯ Ζ̰Ϥ̯ ϢϧϮΘΑ ΪϳΎη Ϫϴ̩ ΕέϮψϨϣ ̶̴Α ϢϬΑ Ϫ̳΍

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