Mr Eugene Nayshtetik Planexta Inc. 1600 Main Street #179 Venice, California 90291 USA
Agentur Kronstadt GmbH Jungfernstieg 1 20095 Hamburg · Germany
13 March 2017
Geschäftsführer Vladimir Papkov
Dear Mr Nayshtetik, During my studying visit to your office, I had a possibility to test the work of SenceBand prototype being the subject myself. I found satisfactory evidence regarding the feasibility of registration of ECG R waves from one hand with the tested prototype. I have also reviewed your approach to early detection of several life-threatening conditions, including sudden cardiac death and myocardial infarction by registration of P and R waves as you presented in your presentation and a video recording of the head-tohead tests of the SenceBand vs a conventional ECG machine that you had done elsewhere. I can confirm that according to the state-of-the-art clinical guidelines, ECG standards, and public knowledge, RR intervals is the only source of data for Heart Rate Variability (HRV) analysis, which reflects the state of the autonomic nervous system. According to the Standards of measurement, physiological interpretation, and clinical use of HRV adopted by the Task Force of The European Society of Cardiology, and The North American Society of Pacing and Electrophysiology [1], there is a significant relationship between the autonomic nervous system and cardiovascular mortality, including sudden cardiac death. Experimental evidence for an association between a propensity for lethal arrhythmias and signs of either increased sympathetic or reduced vagal activity has encouraged the development of quantitative markers of autonomic activity. The analysis of HRV based on the methods of non-linear dynamics may elicit valuable information for the physiological interpretation of HRV and for the assessment of the risk of sudden cardiac death. Moreover, “for prediction of all-cause mortality, the value of HRV is similar to that of left ventricular ejection fraction, but HRV is superior to left ventricular ejection fraction in predicting arrhythmic events (sudden cardiac death and ventricular tachycardia)” [2]. The above mentioned Task Force suggests that depressed HRV is not a simple reflection of the sympathetic overdrive and/or vagal withdrawal due to poor ventricular performance but that it also reflects depressed vagal activity which has a strong association with the pathogenesis of ventricular arrhythmias and sudden cardiac death. Both time and frequency measures of HRV calculated from long 24-h and short 2 to 15-minutes ECG recordings have been used to predict time to death after myocardial infarction, as well as the risk of all-cause mortality and sudden cardiac death in patients with structural heart disease and a number of other pathophysiological conditions. HRV has considerable potential to assess the role of autonomic nervous system fluctuations in normal healthy individuals and in patients with various cardiovascular and noncardiovascular disorders The PR intervals represent the time that it takes for the electrical impulse generated in the sinus node to travel through the atria and across the atrioventricular node to the ventricles.
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