RESOURCES FOR INSTRUCTORS AND STUDENTS The teaching and learning resources for instructors and students are available online. The instructor resources are password protected and available only to qualified instructors. The student resources are available to everyone. These resources have been carefully designed to enhance student learning, and they make it easier for instructors to prepare dynamic lectures and activities for the classroom.
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Question Bank The revised and expanded question bank includes a variety of question formats: multiple choice, fill-in-theblank, true-false, matching, essay, and challenging “thought” questions. There are approximately 60-70 questions per chapter.
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Medical Topics Guide This document highlights medically-relevant topics covered throughout the book, and will be particularly useful for instructors with a large number of premedical, health science, or nursing students.
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Media Guide This document overviews the multimedia available for students and instructors and contains the text of the voice-over narration for all of the movies.
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References Adapted from the detailed references of Molecular Biology of the Cell, and organized especially for Essential Cell Biology, the References provide a rich compendium of journal and review articles for reference and reading assignments.
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Blackboard® and LMS Integration The movies, book images, and student assessments that accompany the book can be integrated into Blackboard or other learning management systems. These resources are bundled into a “Common Cartridge” that facilitates bulk uploading of textbook resources into Blackboard and other learning management systems.
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There are also a number of media assessments that require students to respond to specific questions about movies on the website or figures in the book. Additional concept questions complement the questions available in the book. “Challenge” questions are included that provide a more experimental perspective or require a greater depth of conceptual understanding.
Cell Explorer This application teaches cell morphology through interactive micrographs that highlight important cellular structures.
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Flashcards Each chapter contains flashcards, built into the website, that allow students to review key terms from the text.
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Glossary The complete glossary from the book is available on the website and can be searched or browsed.
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References A set of references is available for each chapter for further reading and exploration.
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The website contains a variety of self-assessment tools to help students. • Each chapter has a multiple-choice quiz to test basic reading comprehension.
Animations and Videos The 130+ animations and videos, narrated by Julie Theriot (Stanford University School of Medicine), are available in WMV and QuickTime formats.
Student Self-Assessments
“This attractive, accessible, visually oriented text covers the fundamentals of cell biology required to understand biomedical and broader issues that affect students’ lives.”
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—CBE-LIFE SCIENCES EDUCATION
The section headings, concept headings, and figures from the text have been integrated into PowerPoint presentations.
“…the language and terminology used by the authors remain focused at a level appropriate to and accessible by undergraduate students….New users of the textbook will find it accessible and approachable….The instructor resources remain a valuable addition….I highly recommend it to all.”
Figure-Integrated Lecture Outlines
3 Park Square Milton Park Abingdon OX14 4RN
There are over 130 narrated movies, covering a wide range of cell biology topics, which review key concepts in the book and illuminate the cellular microcosm.
The images from the book are available in two convenient formats: PowerPoint® and JPEG.
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Animations and Videos
—THE BIOCHEMIST
Art of Essential Cell Biology, Fourth Edition
“Enthralls the reader….Core concepts are explained from first principles in a manner that is lucid and unambiguous....That the authors have assembled a seminal cell biology textbook cannot be disputed….really ought to be an intrinsic part of every bioscience undergraduate’s essential reading.”
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STUDENTS
PRAISE FOR THE PREVIOUS EDITION
INSTRUCTORS
N
EW
www.garlandscience.com/ecb4
FO
URTH
EDITION
ESSENTIAL CELL BIOLOGY, FOURTH EDITION
NEW IN THE FOURTH EDITION EXTRACELLULAR SPACE
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BRUCE ALBERTS, University of California, San Francisco, USA; DENNIS BRAY, University of Cambridge, UK; KAREN HOPKIN, Science Journalist and Biochemist, USA; ALEXANDER JOHNSON, University of California, San Francisco, USA; JULIAN LEWIS, Emeritus, Cancer Research UK, UK; MARTIN RAFF, University College London, UK; KEITH ROBERTS, Emeritus, John Innes Centre, UK; PETER WALTER, University of California, San Francisco, USA
CYTOSOL plasma membrane
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“Long ago it became evident that the key to every biological problem must finally be sought in the cell, for every living organism is, or at some time has been, a cell.” —The Cell in Development and Heredity, Third Edition by E.B. Wilson
Essential Cell Biology provides a readily accessible introduction to the central concepts of cell biology, and its lively, clear writing and exceptional illustrations make it the ideal textbook for a first course in both cell and molecular biology. The text and figures are easy-to-follow, accurate, clear, and engaging for the introductory student. Molecular detail has been kept to a minimum in order to provide the reader with a cohesive conceptual framework for the basic science that underlies our current understanding of all of biology, including the biomedical sciences. The Fourth Edition has been thoroughly revised, covers the latest developments in this fast-moving field, yet retains the academic level and length of the previous edition. The book is accompanied by a rich package of online student and instructor resources, including over 130 narrated movies, an expanded and updated Question Bank, and new enhanced assessments for students. November 2013 • 864 pages • 860 illustrations Hardback • 978-0-8153-4454-4 • £105.00 Paperback • 978-0-8153-4455-1 • £53.00
E-BOOKS AND CUSTOM PUBLISHING Essential Cell Biology, Fourth Edition is available in a variety of e-book formats, including a custom publishing option. For up-to-date information, please visit www.garlandscience.com/ecb4. E-books are available for lifetime purchase, short or long-term rental, and chapters can be purchased individually. A media-integrated e-book is available from INKLING® that contains figures optimized for digital display, as well as resources from the website integrated into the text, such as animations and videos, quizzes and assessments, and glossary definitions. If your institution is interested in a bulk purchase or subscription to a digital version of Essential Cell Biology, please e-mail science@garland.com.
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TABLE OF CONTENTS
16. 17. 18. 19. 20.
Cells: The Fundamental Units of Life Chemical Components of Cells Energy, Catalysis, and Biosynthesis Protein Structure and Function DNA and Chromosomes DNA Replication, Repair, and Recombination From DNA to Protein: How Cells Read the Genome Control of Gene Expression How Genes and Genomes Evolve Modern Recombinant DNA Technology Membrane Structure Transport Across Cell Membranes How Cells Obtain Energy from Food Energy Generation in Mitochondria and Chloroplasts Intracellular Compartments and Protein Transport Cell Signaling Cytoskeleton The Cell Division Cycle Sexual Reproduction and the Power of Genetics Cellular Communities: Tissues, Stem Cells, and Cancer
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Figure 16.18 All GPCRs possess a similar structure.
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HALLMARK FEATURES • •
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STROMA
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+
DP + H + NA
NADPH
nferredoxi uctase NADP red
A sample chapter and a detailed table of contents are available at www.garlandscience.com/ecb4.
Comprehensive scientific update of the entire text and figures in the book. New material on regulatory RNAs, epigenetics, induced pluripotent stem cells, cell suicide and reprogramming, the human genome, and our surprising inheritance from Neanderthals. Based on extensive student feedback, improved discussion and new figures of photosynthesis, metabolism, and DNA repair. Updated coverage of many exciting, new experimental techniques including RNAi, optogenetics, the applications of new DNA sequencing technologies, and the use of mutant organisms to probe the defects underlying human disease. Medically relevant topics include new sections on culturing human cells for clinical work, autism and iPS cells, peroxisomes and disease, cancer changes in key regulatory pathways, as well as expanded coverage of amyloid proteins and their role in Alzheimer’s and Huntington’s diseases, the use of genome sequencing to identify the rare mutations that predispose us to disease, and much more. New and enhanced student self-assessments available online.
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The authors are known worldwide for their research, teaching, writing, and leadership in science and science education. The text reflects the accuracy, authority, and currency of the renowned Molecular Biology of the Cell, yet it is written at an introductory level. Concept headings descriptively introduce each section. The updated art program emphasizes central concepts without unnecessary detail. “How We Know” sections in every chapter introduce experimental science by explaining both the methods and scientific findings of classical and current experiments. Provocative questions are interspersed throughout the text and at the end of each chapter to test students’ understanding and stimulate curiosity (all questions answered in the back of the book). Panels concisely review basic science, principles, pathways, as well as other topics. Key terms are listed at the end of each chapter. “Essential Concepts” provide a review of each chapter. Contains a detailed, illustrated glossary.
plasma membrane
aquaporins
(A)
water molecules
membrane
(B)
Figure 12.6 Water molecules diffuse rapidly through aquaporin channels in the plasma membrane of some cells. ECB4 n12.400/12.06