GRD Journals- Global Research and Development Journal for Engineering | Volume 5 | Issue 8 | July 2020 ISSN- 2455-5703
Evaluation of Hazard and Minimization of Risk of Nitroglycerin in Pharma Industry using ALOHA & Event Tree Analysis Md. Asif Qureshi Student Department of Industrial Safety Engineering SKSITS, Indore
Nisha Kushwaha Assistant Professor Department of Industrial Safety Engineering SKSITS, Indore
Abstract As we all know chemicals are highly hazardous and toxic in nature. They are hazardous till the stage of manufacturing to the stage of storage. This is a study which has been carried out in a pharma industry where the workers are exposed to Explosive and hazardous chemicals such as Nitroglycerin, Chlorine dioxide, Hydrogen peroxide, Methanol and other like these. In this research physical and chemical properties of chosen chemicals are studied. In the second step we have done checklist analysis where the needed data is collected which is going to be used for further steps.in the next step we have to select a highly hazardous or toxic chemical, Toxicity Calculation and hazardous risk is used to rank the chemicals based on the data gathered from checklist. After these selections are made for highly hazardous or toxic chemical, the next step is to find out what are the consequences and risk we are going to face if there is an accident or release of these toxic chemicals in environment. For this, Event Tree Analysis (ETA) is used in next step. In the next step we have to calculate the risk from ETA and find that how it is dispersed into atmosphere and till how much distance it’s going to affect. In the next step we are to calculate human health and safety loss, using the distance found out by software and compensation amount collected from laws. In the final step we will make the precautionary & preventive measures to avoid the toxicity dispersion of chemicals in atmosphere with emergency preparedness in case of chemical release by any means. Keywords- Nitroglycerin, Event Tree Analysis, ALOHA, Fire Hazard Related to Chemical
I. INTRODUCTION TO HAZARDOUS MATERIAL A. Nitroglycerin Neat Nitroglycerin is diluted in Lactose monohydrate, Propylene glycol, Alcohol and other inert medium e.g. Solvated adhesive of various grades as per the customer’s requirements UP state FDA granted license to manufacture following variants of Nitroglycerin drug substances / bulk drugs. – 15%, 17.5%, 17.7%, 18%, 19%, 20% ,21% and 22% w/w Nitroglycerin in Solvated adhesive – 10% w /w Nitroglycerin in Lactose / Propylene glycol / Ethyl alcohol – 5% w /w Nitroglycerin in Lactose / Propylene glycol / Ethyl alcohol – 2% w /w Nitroglycerin in Lactose / Propylene glycol / Ethyl alcohol B. Hand Sanitizers Hand sanitizer kills 99.6 % germs in 30 seconds. Purified water, generated in state-of-the-art water purification plant, used in the formulation In house quality control of all inputs as per the hand sanitizer Microbiological laboratory equipped with Double door autoclave, incubators (Automatic temperature control), very smooth work station and pass box. C. – – – – –
Compositions Isopropyl Alcohol I.P.: 75% v/v Glycerol I.P.: 1.45% v/v Hydrogen Peroxide Solution I.P. (eq. to H2O2): 0.125% v/v Purified Water: QS Ethyl Alcohol I.P.: 80% v/v Glycerol I.P. 1.45% v/v Hydrogen Peroxide Solution I.P. (eq. to H2O2): 0.125% v/v Purified Water: QS Isopropyl Alcohol I.P.: 70% v/v Chlorhexidine Gluconate Solution I.P.:0.5% w/v (eq. to Chlorhexidine Gluconate) Purified Water I.P.: QS Ethyl Alcohol I.P.: 70% v/v Chlorhexidine Gluconate Solution I.P.: 0.5% w/v (eq. to Chlorhexidine Gluconate) Purified Water I.P.: QS
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