07
ANALGESICS Abuse
The analgesic syndrome accounts for
within the internal structures of the
widespread morbidity and mortality.
kidney. It is caused by long-term use of
It
analgesics (pain medicines), especially
comprises
renal
disease,
hypertension, peptic ulcer, anemia,
over-the-counter
and recurrent headache.
contain phenacetin or acetaminophen,
Epidemiological and clinical evidence
and
gathered
from
drugs such as aspirin or ibuprofen). In
societies
display
many
Western
unsupervised
nonsteroidal
(OTC)
drugs
that
anti-inflammatory
small animals, papillary necrosis
(a
consumption of compound analgesic
disorder of the kidneys in which all or
preparations,
part of the renal papillae die.
particularly
those the
The renal papillae are the areas where
causation of the majority of cases.
the openings of the collecting ducts
Laboratory experiments so far have
enter the kidney and where urine flows
ailed
into
containing
to
satisfactory
phenacetin,
in
produce
an
entirely
model
of
clinical
analgesic nephropathy (damage
IFMSA EGYPT - SCOPH NEWSLETTER
the
ureters)
results
from
prolonged feeding with large doses of aspirin and a number of other anti-
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