Inova Heart and Vascular Institute 2022 Donor Impact Report

INOVA HEART AND VASCULAR INSTITUTE 2022 DONOR IMPACT REPORT

THANK YOU FOR MAKING AN IMPACT IN 2022

Innovation and excellence. Those two words best describe our progress in 2022.

In the face of skyrocketing patient volumes and high levels of acuity, our commitment to world-class care remained steadfast.

With the support of friends, our team rose to the challenge, continuing to focus on world-class patient care and the clinical research that enables our patients to benefit from state-of-the-art diagnostic and therapeutic approaches. Integrated, multidisciplinary teams allow us to identify risk factors and address diagnostic and treatment complexities by incorporating expertise from a variety of medical specialists and practitioners.

An aging population combined with an increase in risk factors means that the national prevalence of cardiovascular disease is expected to rise in the next several decades, underscoring the increasing needs we are facing now and in the years to come.

As you read this report, I hope that you see how your leadership giving touches the lives of our patients, families and team members throughout Northern Virginia.

With gratitude,

Christopher M. O’Connor, MD, MACC, FESC President

Inova Heart and Vascular Institute

2022 INOVA HEART AND VASCULAR INSTITUTE HIGHLIGHTS

99.23%

Procedural Success Rate

6,013 cardiac catheterization procedures and 1,849 coronary stent procedures (86% through radial artery access).

400

100 Thoracic Procedures

58 heart transplants,

39 lung transplants

3 heart/lung combined

Cardiogenic shock patients treated, including transfers from 34 outside hospitals. We continue to serve as a regional hub for these sickest patients

Renovations at Inova Alexandria Hospital Electrophysiology Lab allow us to offer a wider range of procedures, including atrial fibrillation ablation, to patients in Alexandria and Mount Vernon.

Transcatheter aortic valve replacements were the highest in the region and among the top volume programs in the eastern U S

Limb Preservation Center and Aortic Center have seen remarkable growth and are nationally recognized for high performance and excellence.

In recognition of exceptional nursing care and alignment with standard practices of the American Association of Critical-Care Nurses, the Progressive Coronary Care Unit team once again received the Silver Beacon Award for Excellence, a three-year designation.

2022 INOVA HEART AND VASCULAR INSTITUTE ACHIEVEMENTS

We are grateful to the Dudley family for their continued support for the Inova Dudley Family Center for Cardiovascular Innovation.

We’ve continued to strengthen community partnerships with other hospitals throughout the region through our care model for treating cardiogenic shock. Inova has provided a blueprint for excellence that has had an impact throughout the DC metro region, nationally and internationally The efficacy of this care model is highlighted once again through publications in prestigious journals.

9th

in the U.S. in heart transplant volume and our survival rate is excellent. Improvements in care delivery are evident in our approach to managing and treating heart failure.

Recent innovations in our cardiac surgery program, including the use of robotically assisted minimally invasive techniques, open the option for bypass surgery to patients who would otherwise not have been surgical candidates due to frailty, co-morbidities or social factors

Our specially trained surgery team led by Dr. Ramesh Singh is the first in Northern Virginia and one of a few select centers in the US to offer this option. Patients have fewer risks, experience less pain and bleeding, and recover in days instead of months.

Tremendous gains have been made in the treatment of valvular disease with transcatheter valve replacement and repair procedures. Early identification is key along with the development of new targeted and personalized strategies to predict the likelihood of major adverse cardiac events post-procedure.

The Inova Heart and Vascular Institute Structural Heart Team achieved national prominence by performing two live cases for the 2022 Society for Cardiovascular Angiography and Interventions Scientific Sessions: A high-risk, Impella-supported percutaneous coronary intervention and a technically challenging transcatheter aortic valve replacement. Outcomes were excellent, thanks to the amazing work of the teams.

For the second consecutive year, our team received the Mitral Valve Repair Reference Center Award from the American Heart Association and the Mitral Foundation for our demonstrated record of superior clinical outcomes. In early 2022, the Structural Heart Team celebrated their 200th MitraClip procedure. We are the highest volume program in the Washington, DC Metro region and among the top volume programs in the east. The team has also implanted 500 Watchman Devices to reduce the risk of stroke in patients with non-valvular atrial fibrillation.

Cynthia's Story: Inova Limb Preservation Program Prevents a Double Amputation

Donations to support Inova’s Limb Preservation program help fund research and enhanced patient care for those individuals like Cynthia who face limb-threatening conditions.

When federal police officer, Cynthia Martin experie heels as a result of blocked arteries and poor blood wound care specialists she was working with left h had an angiogram with a vascular specialist, and the only thing we could do was amputate both legs. " In desperation, she searched online for "wound care scheduled an appointment at an Inova Wound Hea

"

Once I was at Inova, they said they were going to could to save my legs, " Cynthia said. It gave her ho that her condition might improve.

Advanced wound treatment was initiated, and Cyn Dipankar Mukherjee, MD, Chief of Vascular Surgery at Inova Fairfax Hospital, who determined she needed bypass surgery in her left leg Her symptoms improved nearly immediately and Inova's wound specialists worked for several months to save both of her legs.

When the sores on Cynthia's right foot worsened, the team sprang into action to coordinate a timely intervention In April 2022, bypass surgery was performed on her right leg and treatment using advanced wound care continued. Today, all of her sores have healed, and she is back on her feet. Cynthia is in physical therapy to increase her strength after spending so much of the last two years immobile, and she's grateful every day that she still can walk at all.

"The wound healing and limb preservation team at Inova changed my life. If I hadn't sought their opinion, I would have lost my legsand that would have been absolutely devastating. "

Cynthia

Inova has partnered with the Amputation Prevention Alliance to address the urgent public health challenge of preventable diabetesrelated amputations through targeted policy changes to raise awarenees and increase access to care with organizations like Inova that preserve limbs and lives.

Martin, Inova Patient

Second Surgery to Repair a Congenital Heart Defect

Funding from donors helped Inova to recruit a Director of the Adult Congenital Heart Center in 2022 to treat more patients like Scott.

"I owe my life to the skills of my surgeon Dr. Collazo, his surgical team, the nurses and all of the support staff at Inova Fairfax

Scott Boccia had always been healthy and active "I was the kid that played every sport possible I went on to play, and later coach, football, " he says In his 40s, he was a busy dad to three young kids and an involved youth sports coach Life was good until he started noticing that he'd become exhausted and dizzy after an elliptical workout or a short sprint

Scott was diagnosed with a bicuspid aortic valve, a type of congenital heart disease and a structural defect that had been present since birth. In early 2012, Scott had surgery at a non-Inova hospital to replace the damaged valve with a valve made of cow tissue. The surgery went smoothly, and within two months, he was recovered and feeling well. "I wish the story ended there, " he says. It wasn't that simple.

“I was plugged back into my active lifestyle, but five years later I realized something wasn’t right, ” he says. He began feeling tired and short of breath. His valve was failing, and he needed surgery to replace it as soon as possible. “After hours of research, I selected Dr. Collazo, who is an expert in the field of children’s and adult congenital heart disease procedures, ” he says. It was a decision that may have saved his life.

Scott's surgery was complex. The damage to the valve had put significant stress on his heart. "He was in heart failure, " Dr. Collazo says. He replaced the damaged tissue with a new-generation mechanical valve designed to last a lifetime. The replacement went smoothly, but the stress of the surgery combined with heart failure led fluid to build up in Scott's lungs His recovery was challenging “I spent the next 36 days in a hospital bed I had to relearn how to walk, write and speak, ” he says Today, Scott is healthy and active, and says he remains grateful that he chose Inova for his second surgery

To read the complete story, visit: This Inova Newsroom Link here.

Hospital. "

Scott Boccia, Inova Patient

RESEARCH UPDATES: IMPROVING PATIENT OUTCOMES

With generous support from our donors, our team can set aside protected time for research that fuels Inova's mission to provide world-class, integrated care and our vision to be among the leading health systems in the nation. In 2022, physicians and clinicians at Inova Heart and Vascular Institute participated in drug trials, consensus recommendations and dissemination of findings that clearly establishes our preeminence in the field of heart and vascular medicine.

The Advanced Heart Failure Research and Ventricular Assistive Device Teams, led by Palak Shah and Mary Looby, PharmD, launched the first Inova FDA Investigational New Drug trial, a single-center, randomized-controlled trial designed to evaluate the safety of apixaban, an anticoagulent that reduces risk of blood clots in patients supported by left ventricular assist devices (LVADs). The results of this trial may change anticoagulation from warfarin-based to apixaban for future generations of patients with LVADs.

Dr. O'Connor and team presented consensus recommendations by the Heart Failure Academic Research Consortium on changes in healthrelated quality of life and functional capacity in Functional and Symptomatic Clinical Trial

Endpoints: The HFC-ARC Scientific Expert Panel State-Of-The-Art Paper, Mitchell Psotka, Christopher M. O’Connor, et al Journal of the American College of Cardiology Nov 09, 2022

Acute coronary syndrome in older adults is addressed in Damluji AA, et al American Heart Association Cardiovascular Disease in Older Populations Committee of the Council on Clinical Cardiology; Council on Lifestyle and Cardiometabolic Health; and Council on Cardiovascular Radiology and Intervention. Management of Acute Coronary Syndrome in the Older Adult Population: A Scientific Statement From the American Heart Association. Circulation Dec 12, 2022

The importance of identifying frailty and intervening appropriately is highlighted in Ijaz

N, Buta B, Xue QL, Mohess DT, Bushan A, Tran H, Batchelor W, deFilippi CR, Walston

JD, Bandeen-Roche K, Forman DE, Resar JR, O’Connor CM, Gerstenblith G, Damluji

AA. Interventions for Frailty Among Older Adults With Cardiovascular Disease: Journal of the American College of Cardiology, State-of-the-Art Review. Feb 8, 2022.

INVESTING IN THE FUTURE Research Fellowships, Education and Training

Inova Heart and Vascular Institute has partnered with George Mason University to create a post-doctorate two-year research fellowship to provide opportunities for early-stage clinicians who wish to explore and ideally pursue a career in clinical research This highly selective and rigorous program is led by Inova physicians, Drs. Palak Shah and Abdulla Damluji and Drs. Jiayang Sun, Carolyn Drews-Botsch and Bernard Dunn from George Mason University.

Dr. Jason Goldberg is the first Post-Doctoral Research Fellow under the new Inova Heart and Vascular Institute - George Mason University partnership. He is a pediatric heart failure and transplant cardiologist. His interests center around genomic biomarkers of heart transplant rejection and he will work with Drs. Deneen and Heath and Mitchell Cohen to launch pediatric heart failure and transplantation programs in the fall of 2023

Our 2022 Cherry Blossom Cardiovascular Symposium was a great success with close to 200 onsite attendees, an additional 70+ participating virtually and 30 exhibits. Talks by our esteemed faculty included a look to the future by the preeminent cardiologist Dr. Spencer B. King, III to updates on the latest research and innovation in heart failure, shock, prevention, interventional procedures and electrophysiology with thoughtprovoking cases and panel discussions.

It was our privilege to honor Dr. Dean Pollock with the Inova Heart and Vascular Institute Pioneer Award for his efforts over the years to bring the highest quality cardiovascular care and state-of-the-art interventional procedures to Loudoun County.

ADDRESSING DISPARITIES IN CARE

Reaching out to underserved communities is key to Inova’s mission of caring for all of our Northern Virginia residents.

Inova team members performed blood pressure, lipids, glucose and peripheral artery disease screenings at the August 6 Health and Wellness Fair at Bethlehem Baptist church in Alexandria This outreach initiative helps to address disparities in care in underserved communities

On December 9, 100 seniors from West Potomac Academy spent a day at Inova Fairfax learning physical exam skills, observing surgery, seeing demonstrations in the ASTEC and Advanced Medical Simulation centers and interacting with Inova team members and UVA medical students as part of Dream B!G. This program was conceived and championed by Inova Heart and Vascular Institute Diversity Equity and Inclusion Advisor Dr. Cleve Francis to allow students from underserved communities to explore career opportunities in healthcare.

Thank You!

To all of our generous donors, we are grateful for your continuing support for Inova Heart and Vascular Institute in 2022. Together, you contributed more than $8.2 million in philanthropic investments that are making a difference for thousands of patients and families in our region. Your commitment helps Inova fulfill its mission to deliver world-class, patient-centered care close to home and to achieve our vision to be among the leading healthcare systems in the nation

As we look to the future of healthcare in our community, philanthropy remains essential to Inova to accelerate innovation, excellence in care, and expanded and more equitable access to health education, disease prevention and advanced treatments. In 2018, the Dudley Family Foundation stepped forward with a transformational gift, establishing the Dudley Family Center for Cardiovascular Innovation In 2022, we established the D'Aniello Chair, Atrial Fibrillation and the Inova Reinsch Pierce Cardiomyopathy Program new programs and endowed chairs powered by philanthropy

And, we are proud to share that as of May 23, 2023, with their gift of $75 million, Dwight and Martha Schar are transforming cardiovascular care in our region through the newly named Inova Schar Heart and Vascular. Their gift and subsequent challenge to the community to match their $75 million marks the beginning of an exciting new chapter, and we can't wait to share it with you