M.Naga Jyothi*, et al. / (IJAEST) INTERNATIONAL JOURNAL OF ADVANCED ENGINEERING SCIENCES AND TECHNOLOGIES Vol No. 7, Issue No. 2, 217 - 221
Association of GSTO1 and GSTO2 in Late Onset Alzheimer’s disease:A Bioinformatics approach Dept. Computer Science and Engineering, P.V.P Siddhartha Institute of Technology, Vijayawada,India, mjyothi.mtech@gmail.com
Dr. V.Srinivasa Rao,
Dept. Computer Science and Engineering, P.V.P Siddhartha Institute of Technologyrganization, Vijayawada,India, drknrao@ieee.org
Dr. K.Srinivas,
Professor Dept. Computer Science and Engineering, V.R Siddhartha Engineering College, Vijayawada, India. vrdrks@gmail.com
ES
Professor & Head, Dept. Computer Science and Engineering, V.R Siddhartha Engineering College, Vijayawada, India. drvsrao9@gmail.com
Dr. K.Nageswara Rao, Professor & Head,
T
M.Naga Jyothi,
Abstract— Late-onset Alzheimer’s disease (AD) is a complex and multifactorial form of Alzheimer's disease
Keywords: Dementia, Late Onset Alzheimer’s disease, Protein sequence, Phylogram, Clustalw2
with the possible involvement of several genes. Research is
still going on to find out the major genes that cause this
I.
Alzheimer’s
INTRODUCTION
disease
(AD)
is
a
progressive
neurogenerative disorder that occurs predominantly in later
small proportion of the genetic contribution to Alzheimer’s
life. It is the commonest cause of dementia and represents the
disease can be explained. In the present study, role of
fourth largest cause of death in developed world [1].
genes that are suspected to cause Late Onset Alzheimer’s
Alzheimer’s disease is a genetically complex disease [2].Since
is analyzed through multiple sequence alignment method
the 1990s, the genetics of Alzheimer disease (AD) has been an
using Clustalw2 tool and a phylogram is constructed. This
active area of research. In the early 1990s, segregation analysis
sequence alignment method used, protein sequences of
studies suggested a complex model possibly involved in
disease causing genes. Our study showed that GSTO1,
polygenes and environmental factors emerged for Late Onset
GSTO2 proteins are found to be closely related and play a
Alzheimer’s disease (LOAD) [3, 4]. However, identified genes
typical role amongst all Late Onset Alzheimer’s disease
explain only a small proportion of familial Alzheimer’s disease
proteins. Proteins LRP1 and VLDLR are also found to be
and leave an important gap in late-onset forms, which are those
closely related next to GSTO1 and GSTO2.
most closely resembling sporadic disease. [2].
IJ A
complicated Late Onset Alzheimer’s disease. Yet only a
Analyzing disease causing genes through this
bioinformatics approach would help in finding genes that
II.
MATERIALS AND METHODS:
are most likely involved in causing disease.Indepth study
We have collected 46 genes that are supposed to be
of such genes may find a solution to prevent late Onset
the cause for LOAD through literature survey of various
Alzheimer’s disease.
papers related to Alzheimer’s [5, 6, 7, 8, and 9] and from www.genecards.org.The corresponding protein sequences in
ISSN: 2230-7818
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